ZNF106

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)9.44244080
2regulation of skeletal muscle contraction (GO:0014819)9.42698990
3actin-myosin filament sliding (GO:0033275)9.32007906
4muscle filament sliding (GO:0030049)9.32007906
5plasma membrane repair (GO:0001778)8.46961214
6negative regulation of potassium ion transmembrane transport (GO:1901380)8.40450959
7regulation of sarcomere organization (GO:0060297)8.19084966
8actin-mediated cell contraction (GO:0070252)7.85135664
9cardiac myofibril assembly (GO:0055003)7.80809471
10sarcoplasmic reticulum calcium ion transport (GO:0070296)7.80740071
11myofibril assembly (GO:0030239)7.70496703
12response to stimulus involved in regulation of muscle adaptation (GO:0014874)7.15409213
13sarcomere organization (GO:0045214)7.12715634
14negative regulation of protein localization to cell surface (GO:2000009)6.73418798
15response to inactivity (GO:0014854)6.64421888
16regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)6.62562582
17regulation of relaxation of muscle (GO:1901077)6.49564649
18striated muscle atrophy (GO:0014891)6.32781983
19actin filament-based movement (GO:0030048)6.08602514
20skeletal muscle contraction (GO:0003009)6.07303368
21response to muscle activity (GO:0014850)5.97544589
22positive regulation of myotube differentiation (GO:0010831)5.77350165
23positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.75941315
24striated muscle contraction (GO:0006941)5.74869501
25negative regulation of muscle hypertrophy (GO:0014741)5.65877553
26muscle atrophy (GO:0014889)5.60606911
27cardiac muscle contraction (GO:0060048)5.59312786
28muscle cell cellular homeostasis (GO:0046716)5.49930324
29regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.49738579
30skeletal muscle adaptation (GO:0043501)5.42258927
31actomyosin structure organization (GO:0031032)5.36229373
32regulation of cell communication by electrical coupling (GO:0010649)5.20465091
33negative regulation of nitric-oxide synthase activity (GO:0051001)5.14110053
34regulation of actin filament-based movement (GO:1903115)5.05505652
35cardiac muscle hypertrophy (GO:0003300)4.90420581
36regulation of membrane repolarization (GO:0060306)4.90280890
37cardiac muscle cell development (GO:0055013)4.86145482
38striated muscle adaptation (GO:0014888)4.82411910
39ventricular cardiac muscle cell action potential (GO:0086005)4.79441682
40negative regulation of cardiac muscle hypertrophy (GO:0010614)4.70792759
41striated muscle hypertrophy (GO:0014897)4.65466563
42skeletal muscle tissue regeneration (GO:0043403)4.64644097
43regulation of striated muscle contraction (GO:0006942)4.53788505
44cardiac cell development (GO:0055006)4.53175221
45negative regulation of heart growth (GO:0061117)4.49129431
46negative regulation of cardiac muscle tissue growth (GO:0055022)4.49129431
47myoblast fusion (GO:0007520)4.48728204
48heart process (GO:0003015)4.46962271
49heart contraction (GO:0060047)4.46962271
50regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.43939633
51regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.41066971
52skeletal muscle fiber development (GO:0048741)4.32664349
53membrane raft organization (GO:0031579)4.27643525
54muscle contraction (GO:0006936)4.17462129
55regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.17086211
56cardiac muscle tissue morphogenesis (GO:0055008)4.14925623
57negative regulation of cell size (GO:0045792)4.13872227
58muscle hypertrophy (GO:0014896)4.12802870
59skeletal muscle tissue development (GO:0007519)4.12376836
60negative regulation of potassium ion transport (GO:0043267)4.08827827
61positive regulation of myoblast differentiation (GO:0045663)4.08415451
62muscle tissue morphogenesis (GO:0060415)4.03292864
63myotube cell development (GO:0014904)4.03236574
64positive regulation of microtubule polymerization (GO:0031116)3.98895767
65syncytium formation by plasma membrane fusion (GO:0000768)3.93893169
66muscle system process (GO:0003012)3.93172699
67regulation of p38MAPK cascade (GO:1900744)3.85577378
68muscle cell fate commitment (GO:0042693)3.84829935
69regulation of calcium ion transmembrane transport (GO:1903169)3.83129354
70regulation of calcium ion transmembrane transporter activity (GO:1901019)3.83129354
71negative regulation of organelle assembly (GO:1902116)3.81507911
72muscle adaptation (GO:0043500)3.80111217
73regulation of cardiac muscle cell differentiation (GO:2000725)3.75350112
74regulation of muscle hypertrophy (GO:0014743)3.74418279
75heart trabecula formation (GO:0060347)3.72812329
76ribonucleoprotein complex disassembly (GO:0032988)3.72308544
77creatine metabolic process (GO:0006600)3.70828394
78striated muscle cell development (GO:0055002)3.67501404
79regulation of the force of heart contraction (GO:0002026)3.66257345
80positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.66054964
81myotube differentiation (GO:0014902)3.61861226
82muscle fiber development (GO:0048747)3.60327505
83regulation of potassium ion transmembrane transporter activity (GO:1901016)3.57786899
84muscle organ development (GO:0007517)3.56368816
85cardiac muscle hypertrophy in response to stress (GO:0014898)3.56349632
86muscle hypertrophy in response to stress (GO:0003299)3.56349632
87cardiac muscle adaptation (GO:0014887)3.56349632
88muscle structure development (GO:0061061)3.53467593
89adult heart development (GO:0007512)3.53065536
90regulation of action potential (GO:0098900)3.48759334
91cardiac muscle cell action potential (GO:0086001)3.43276526
92regulation of cardiac muscle contraction (GO:0055117)3.42048589
93relaxation of cardiac muscle (GO:0055119)3.41963223
94regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.41826059
95regulation of muscle adaptation (GO:0043502)3.41533032
96nucleus localization (GO:0051647)3.34659514
97regulation of cardiac muscle hypertrophy (GO:0010611)3.34140494
98cardiac muscle cell action potential involved in contraction (GO:0086002)3.32521958
99positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.32126435
100negative regulation of monooxygenase activity (GO:0032769)3.26767883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.89813134
2GATA1_22025678_ChIP-Seq_K562_Human4.62044586
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.42499793
4VDR_22108803_ChIP-Seq_LS180_Human3.28754988
5CDX2_19796622_ChIP-Seq_MESCs_Mouse2.99457847
6TBX20_22328084_ChIP-Seq_HEART_Mouse2.95314168
7TBX20_22080862_ChIP-Seq_HEART_Mouse2.95314168
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.86327822
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.74434738
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.62410545
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.53205709
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.22068638
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.20331657
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.12936255
15EZH2_22144423_ChIP-Seq_EOC_Human2.09002265
16MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.02862103
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.82205804
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.82205804
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.82205804
20GATA4_21415370_ChIP-Seq_HL-1_Mouse1.78070334
21IGF1R_20145208_ChIP-Seq_DFB_Human1.70029477
22CTNNB1_20460455_ChIP-Seq_HCT116_Human1.67205012
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65438584
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.62577987
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58456981
26PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.53466722
27NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.52370179
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51170460
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.49961667
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49194912
31TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.47958263
32NFIB_24661679_ChIP-Seq_LUNG_Mouse1.47725641
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45614944
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45501416
35CJUN_26792858_Chip-Seq_BT549_Human1.45249442
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41458023
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40396938
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.40369255
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40147707
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39904150
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39586483
42GBX2_23144817_ChIP-Seq_PC3_Human1.37986164
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36558480
44E2F1_18555785_Chip-Seq_ESCs_Mouse1.33499117
45SMAD4_21799915_ChIP-Seq_A2780_Human1.33260564
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29134265
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28505116
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27738512
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27738512
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24745255
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.22857976
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21479083
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20902092
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.20542479
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18733762
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18708339
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18633651
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17079239
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.16063641
60GATA1_19941827_ChIP-Seq_MEL86_Mouse1.14097252
61LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13867635
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12505166
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11831585
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11444910
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11426068
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10417643
67BRD4_25478319_ChIP-Seq_HGPS_Human1.09040376
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08638525
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.08318822
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08048134
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07872850
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07685655
73P53_22387025_ChIP-Seq_ESCs_Mouse1.07189318
74STAT3_23295773_ChIP-Seq_U87_Human1.07025578
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05274224
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.03314364
77TCF4_23295773_ChIP-Seq_U87_Human1.02727839
78TP53_16413492_ChIP-PET_HCT116_Human1.02646672
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01435914
80OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99157469
81GF1_26923725_Chip-Seq_HPCs_Mouse0.97730750
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97578380
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97384896
84CRX_20693478_ChIP-Seq_RETINA_Mouse0.97175747
85ZFX_18555785_Chip-Seq_ESCs_Mouse0.96943435
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.96767698
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96379720
88NANOG_18555785_Chip-Seq_ESCs_Mouse0.95358147
89FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94520918
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94331591
91ISL1_27105846_Chip-Seq_CPCs_Mouse0.94263167
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94237487
93OCT4_18555785_Chip-Seq_ESCs_Mouse0.93827229
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93679275
95WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93651898
96ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91558532
97SOX2_18555785_Chip-Seq_ESCs_Mouse0.91024634
98TAF15_26573619_Chip-Seq_HEK293_Human0.90345354
99PU1_27457419_Chip-Seq_LIVER_Mouse0.89603370
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88008297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy6.28315362
2MP0000749_muscle_degeneration6.26746779
3MP0004084_abnormal_cardiac_muscle5.14958889
4MP0003950_abnormal_plasma_membrane5.03626477
5MP0004036_abnormal_muscle_relaxation4.44670792
6MP0004145_abnormal_muscle_electrophysio4.36613101
7MP0003646_muscle_fatigue4.22416641
8MP0004087_abnormal_muscle_fiber3.33405820
9MP0002837_dystrophic_cardiac_calcinosis3.23364080
10MP0005330_cardiomyopathy3.13961535
11MP0002106_abnormal_muscle_physiology3.11801377
12MP0002269_muscular_atrophy3.00293402
13MP0000759_abnormal_skeletal_muscle2.95963910
14MP0004215_abnormal_myocardial_fiber2.86366226
15MP0000750_abnormal_muscle_regeneration2.73919667
16MP0005620_abnormal_muscle_contractility2.72858154
17MP0000747_muscle_weakness2.67613058
18MP0002972_abnormal_cardiac_muscle2.61974704
19MP0005369_muscle_phenotype2.59132897
20MP0004484_altered_response_of2.30580475
21MP0004130_abnormal_muscle_cell2.25727815
22MP0002332_abnormal_exercise_endurance2.20162277
23MP0010630_abnormal_cardiac_muscle2.13459829
24MP0003828_pulmonary_edema2.03550217
25MP0004233_abnormal_muscle_weight2.00223263
26MP0006138_congestive_heart_failure1.89371243
27MP0001544_abnormal_cardiovascular_syste1.85053987
28MP0005385_cardiovascular_system_phenoty1.85053987
29MP0004510_myositis1.84471815
30MP0000733_abnormal_muscle_development1.79982818
31MP0002108_abnormal_muscle_morphology1.76683375
32MP0008775_abnormal_heart_ventricle1.74085037
33MP0005171_absent_coat_pigmentation1.65238803
34MP0000569_abnormal_digit_pigmentation1.63808914
35MP0005451_abnormal_body_composition1.62062615
36MP0002127_abnormal_cardiovascular_syste1.58684925
37MP0000372_irregular_coat_pigmentation1.51675251
38MP0003221_abnormal_cardiomyocyte_apopto1.49876480
39MP0004270_analgesia1.44187114
40MP0003137_abnormal_impulse_conducting1.23833908
41MP0004272_abnormal_basement_membrane0.98600619
42MP0008438_abnormal_cutaneous_collagen0.97264913
43MP0001661_extended_life_span0.95363506
44MP0005670_abnormal_white_adipose0.94321142
45MP0002971_abnormal_brown_adipose0.92543455
46MP0003705_abnormal_hypodermis_morpholog0.91092220
47MP0004085_abnormal_heartbeat0.89784212
48MP0003045_fibrosis0.89418688
49MP0005266_abnormal_metabolism0.89065282
50MP0000013_abnormal_adipose_tissue0.85278687
51MP0000266_abnormal_heart_morphology0.83853726
52MP0009780_abnormal_chondrocyte_physiolo0.83096777
53MP0006036_abnormal_mitochondrial_physio0.82322599
54MP0002102_abnormal_ear_morphology0.81961257
55MP0001958_emphysema0.79394476
56MP0005165_increased_susceptibility_to0.76666326
57MP0005187_abnormal_penis_morphology0.75683625
58MP0003279_aneurysm0.75050598
59MP0003136_yellow_coat_color0.73487026
60MP0005275_abnormal_skin_tensile0.72403829
61MP0010368_abnormal_lymphatic_system0.72203843
62MP0001299_abnormal_eye_distance/0.71339204
63MP0000015_abnormal_ear_pigmentation0.71180645
64MP0002877_abnormal_melanocyte_morpholog0.69771166
65MP0005408_hypopigmentation0.57953360
66MP0002128_abnormal_blood_circulation0.57383736
67MP0004381_abnormal_hair_follicle0.57020576
68MP0000767_abnormal_smooth_muscle0.54022839
69MP0001542_abnormal_bone_strength0.53375619
70MP0004883_abnormal_blood_vessel0.52462479
71MP0005409_darkened_coat_color0.51689532
72MP0005666_abnormal_adipose_tissue0.50528100
73MP0003091_abnormal_cell_migration0.49794241
74MP0002896_abnormal_bone_mineralization0.48486877
75MP0005375_adipose_tissue_phenotype0.45949919
76MP0002009_preneoplasia0.43617134
77MP0002095_abnormal_skin_pigmentation0.40281950
78MP0000003_abnormal_adipose_tissue0.39818077
79MP0003566_abnormal_cell_adhesion0.39318686
80MP0000467_abnormal_esophagus_morphology0.36819386
81MP0004134_abnormal_chest_morphology0.36263048
82MP0002133_abnormal_respiratory_system0.35060011
83MP0005388_respiratory_system_phenotype0.35060011
84MP0004185_abnormal_adipocyte_glucose0.34914131
85MP0005623_abnormal_meninges_morphology0.31583116
86MP0005174_abnormal_tail_pigmentation0.31040266
87MP0001879_abnormal_lymphatic_vessel0.28943296
88MP0002114_abnormal_axial_skeleton0.28417433
89MP0010030_abnormal_orbit_morphology0.28199607
90MP0005376_homeostasis/metabolism_phenot0.28121398
91MP0000371_diluted_coat_color0.27809362
92MP0005503_abnormal_tendon_morphology0.27122330
93MP0005166_decreased_susceptibility_to0.26920675
94MP0000230_abnormal_systemic_arterial0.26316392
95MP0003763_abnormal_thymus_physiology0.26112849
96MP0003385_abnormal_body_wall0.25050619
97MP0001915_intracranial_hemorrhage0.24976699
98MP0009115_abnormal_fat_cell0.23588199
99MP0008770_decreased_survivor_rate0.21203123
100MP0002925_abnormal_cardiovascular_devel0.21193157

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)8.16808521
2Calf muscle hypertrophy (HP:0008981)8.08240061
3Nemaline bodies (HP:0003798)8.04202977
4Muscle hypertrophy of the lower extremities (HP:0008968)7.76290994
5Muscle fiber inclusion bodies (HP:0100299)7.76114867
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.75741436
7Exercise-induced muscle cramps (HP:0003710)7.74693714
8Subaortic stenosis (HP:0001682)6.70780502
9Abnormality of the left ventricular outflow tract (HP:0011103)6.70780502
10Sudden death (HP:0001699)6.68176160
11Type 1 muscle fiber predominance (HP:0003803)6.40197149
12Asymmetric septal hypertrophy (HP:0001670)5.85197575
13Abnormality of the calf musculature (HP:0001430)5.78080224
14Hyporeflexia of lower limbs (HP:0002600)5.60671619
15Neck muscle weakness (HP:0000467)4.93763194
16Distal arthrogryposis (HP:0005684)4.82055486
17Distal lower limb muscle weakness (HP:0009053)4.76030031
18Muscle fiber splitting (HP:0003555)4.45385936
19EMG: myopathic abnormalities (HP:0003458)4.39553400
20Bundle branch block (HP:0011710)4.09239375
21Round ear (HP:0100830)4.04669733
22Myotonia (HP:0002486)4.00977538
23Muscle stiffness (HP:0003552)3.88268735
24Myopathic facies (HP:0002058)3.78625541
25Ulnar deviation of the wrist (HP:0003049)3.70058306
26Gowers sign (HP:0003391)3.63041726
27Difficulty running (HP:0009046)3.48182317
28Rhabdomyolysis (HP:0003201)3.46598735
29Myoglobinuria (HP:0002913)3.41256064
30Centrally nucleated skeletal muscle fibers (HP:0003687)3.31977070
31Abnormality of skeletal muscle fiber size (HP:0012084)3.30896507
32Rimmed vacuoles (HP:0003805)3.30073809
33Increased connective tissue (HP:0009025)3.27442675
34Areflexia of lower limbs (HP:0002522)3.24788942
35Lipoatrophy (HP:0100578)3.22223672
36Calcaneovalgus deformity (HP:0001848)3.21173706
37EMG: neuropathic changes (HP:0003445)3.15930182
38Popliteal pterygium (HP:0009756)3.15916320
39Increased variability in muscle fiber diameter (HP:0003557)3.06259263
40Ventricular arrhythmia (HP:0004308)3.03387563
41Ventricular tachycardia (HP:0004756)3.01362438
42Malignant hyperthermia (HP:0002047)2.96048540
43Fetal akinesia sequence (HP:0001989)2.86474758
44Fatigable weakness (HP:0003473)2.83099876
45Abnormality of the neuromuscular junction (HP:0003398)2.83099876
46Deformed tarsal bones (HP:0008119)2.82900786
47Frequent falls (HP:0002359)2.82804295
48Dilated cardiomyopathy (HP:0001644)2.78052934
49Weak cry (HP:0001612)2.76915788
50Absent phalangeal crease (HP:0006109)2.76670571
51Atrial fibrillation (HP:0005110)2.74571518
52Type 2 muscle fiber atrophy (HP:0003554)2.72719796
53Prolonged QT interval (HP:0001657)2.63672979
54Scapular winging (HP:0003691)2.57738884
55Distal lower limb amyotrophy (HP:0008944)2.51596544
56Generalized muscle weakness (HP:0003324)2.48172495
57Primary atrial arrhythmia (HP:0001692)2.40023272
58Abnormal finger flexion creases (HP:0006143)2.39538316
59Arterial tortuosity (HP:0005116)2.32977680
60Muscle fiber atrophy (HP:0100295)2.31736270
61Heart block (HP:0012722)2.31378209
62Supraventricular tachycardia (HP:0004755)2.28335024
63Mildly elevated creatine phosphokinase (HP:0008180)2.25514854
64Supraventricular arrhythmia (HP:0005115)2.22601495
65Bulbar palsy (HP:0001283)2.21670284
66Aortic aneurysm (HP:0004942)2.21003611
67Abnormal atrioventricular conduction (HP:0005150)2.19872091
68Metatarsus adductus (HP:0001840)2.14557540
69Vascular tortuosity (HP:0004948)2.14499144
70Limb-girdle muscle atrophy (HP:0003797)2.12462115
71Abnormality of placental membranes (HP:0011409)2.09927162
72Amniotic constriction ring (HP:0009775)2.09927162
73Syncope (HP:0001279)2.04505277
74Abnormality of the foot musculature (HP:0001436)2.03814295
75Hip contracture (HP:0003273)2.03335404
76Steppage gait (HP:0003376)2.02881846
77Lower limb amyotrophy (HP:0007210)2.01551789
78Atrioventricular block (HP:0001678)1.90612862
79Foot dorsiflexor weakness (HP:0009027)1.89854661
80Left ventricular hypertrophy (HP:0001712)1.87780614
81Proximal amyotrophy (HP:0007126)1.87597292
82Abnormal EKG (HP:0003115)1.86293476
83Spinal rigidity (HP:0003306)1.83724091
84Protrusio acetabuli (HP:0003179)1.83296191
85Right ventricular cardiomyopathy (HP:0011663)1.82616252
86Abnormality of the shoulder girdle musculature (HP:0001435)1.82051438
87Nonprogressive disorder (HP:0003680)1.79934312
88Abnormality of the calcaneus (HP:0008364)1.77642238
89Muscular dystrophy (HP:0003560)1.75802311
90Respiratory insufficiency due to muscle weakness (HP:0002747)1.75237069
91Aplasia of the musculature (HP:0100854)1.74921145
92Ventricular fibrillation (HP:0001663)1.70861251
93Easy fatigability (HP:0003388)1.69827872
94Renal cortical cysts (HP:0000803)1.69138233
95Palpitations (HP:0001962)1.62181514
96Waddling gait (HP:0002515)1.59899805
97Long clavicles (HP:0000890)1.59162551
98Slender build (HP:0001533)1.58607693
99Limited hip movement (HP:0008800)1.58054296
100Difficulty climbing stairs (HP:0003551)1.57895541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN9.10939435
2TTN5.10808805
3MUSK4.41014219
4PIK3CG3.92684239
5PHKG13.37301497
6PHKG23.37301497
7DMPK3.13007980
8MAP3K72.73025064
9MAPKAPK52.64266793
10CCNB12.41445065
11MAPK122.02461930
12CDK81.95205406
13MYLK1.59099451
14SCYL21.51196236
15MAP2K31.51179380
16TRPM71.46667288
17MOS1.46553025
18NEK91.37291121
19PIK3CA1.17551002
20PINK11.16955402
21MAPK71.16878303
22MELK1.07504825
23PRKAA20.99460379
24MAP3K100.98757214
25CAMK2D0.95816003
26MARK20.94622804
27EEF2K0.89243897
28PAK60.88861637
29MAPKAPK30.82933278
30PDK20.82556114
31SGK20.81810453
32MARK10.75698310
33TGFBR20.72630431
34SGK30.72243866
35PRKACB0.69482129
36MAPK40.65951327
37CAMK2G0.65375416
38BLK0.63111018
39MAP2K10.62563961
40PRKAA10.58850647
41PAK30.56341977
42CDK90.55774867
43CAMK40.53274589
44ROCK10.52530981
45STK40.52380434
46PAK20.50693435
47CAMK2A0.49671578
48PRKD10.48903800
49MAP2K40.48340768
50CDK40.47886062
51PRKG10.47779564
52LIMK10.45636691
53MAP3K60.45341588
54CAMK2B0.43975866
55AKT20.43534530
56CAMK10.43259579
57MAP3K50.43170288
58DDR20.40167126
59NEK10.39724807
60STK38L0.38338156
61ERBB30.38027743
62KSR20.36974311
63FGFR30.36269824
64MTOR0.35512239
65NLK0.35309496
66BRD40.35209071
67MARK30.33669175
68RPS6KA30.33457359
69TIE10.33163883
70ROCK20.33152095
71ZAP700.32170356
72STK240.32153070
73EIF2AK30.31772831
74MAP3K30.31143863
75FGFR10.30811962
76PKN10.30450144
77SGK4940.29905155
78SGK2230.29905155
79PDGFRA0.29859522
80CDC42BPA0.29345710
81FER0.29262210
82RPS6KB10.29073842
83LATS10.28758853
84JAK10.28414539
85MAPK100.28249277
86CSNK1D0.27328472
87RIPK10.26977483
88MAPK110.25853353
89PRKACA0.25729876
90SGK10.25184790
91WNK10.24324404
92PRPF4B0.24114761
93PKN20.22163476
94MAP3K130.19906816
95EPHA30.19023812
96PRKACG0.17882240
97PDK10.17055787
98EPHB10.16905682
99PDGFRB0.16536845
100SYK0.16280651

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054105.38772062
2Dilated cardiomyopathy_Homo sapiens_hsa054145.18152047
3Cardiac muscle contraction_Homo sapiens_hsa042603.95256559
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.66097366
5Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.67368009
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.54539109
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.30708176
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.18929515
9Circadian rhythm_Homo sapiens_hsa047101.95292912
10Pyruvate metabolism_Homo sapiens_hsa006201.95238696
11Viral myocarditis_Homo sapiens_hsa054161.84396175
12cGMP-PKG signaling pathway_Homo sapiens_hsa040221.76187679
13Focal adhesion_Homo sapiens_hsa045101.72864602
14Propanoate metabolism_Homo sapiens_hsa006401.69233388
15Glucagon signaling pathway_Homo sapiens_hsa049221.65910758
16Oxytocin signaling pathway_Homo sapiens_hsa049211.60316218
17Insulin signaling pathway_Homo sapiens_hsa049101.56866487
18Insulin resistance_Homo sapiens_hsa049311.51272063
19Calcium signaling pathway_Homo sapiens_hsa040201.45222932
20Adherens junction_Homo sapiens_hsa045201.43983696
21Lysine degradation_Homo sapiens_hsa003101.39411976
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35924203
23Fatty acid degradation_Homo sapiens_hsa000711.34294968
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.33202336
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14630405
26Tight junction_Homo sapiens_hsa045301.14571734
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13976443
28Arginine and proline metabolism_Homo sapiens_hsa003301.13478212
29beta-Alanine metabolism_Homo sapiens_hsa004101.13123176
30Carbon metabolism_Homo sapiens_hsa012001.12959251
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.11257115
32Renin secretion_Homo sapiens_hsa049241.11042009
33AMPK signaling pathway_Homo sapiens_hsa041521.09853949
34Histidine metabolism_Homo sapiens_hsa003401.01992477
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.01509307
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99836283
37Proteoglycans in cancer_Homo sapiens_hsa052050.99800040
38FoxO signaling pathway_Homo sapiens_hsa040680.97834307
39Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94995917
40Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94722284
41Pancreatic secretion_Homo sapiens_hsa049720.88334003
42Gastric acid secretion_Homo sapiens_hsa049710.88310094
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87353792
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.85661139
45ECM-receptor interaction_Homo sapiens_hsa045120.83896390
46Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79069525
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78085842
48Amoebiasis_Homo sapiens_hsa051460.78049357
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76387362
50Colorectal cancer_Homo sapiens_hsa052100.75377089
51Platelet activation_Homo sapiens_hsa046110.74041869
52GnRH signaling pathway_Homo sapiens_hsa049120.71992627
53Long-term potentiation_Homo sapiens_hsa047200.70890823
54Renal cell carcinoma_Homo sapiens_hsa052110.70452147
55cAMP signaling pathway_Homo sapiens_hsa040240.69937163
56Pancreatic cancer_Homo sapiens_hsa052120.68768419
57ABC transporters_Homo sapiens_hsa020100.68555889
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65432044
59Alzheimers disease_Homo sapiens_hsa050100.62813804
60Tryptophan metabolism_Homo sapiens_hsa003800.58312626
61Gap junction_Homo sapiens_hsa045400.55422729
62PPAR signaling pathway_Homo sapiens_hsa033200.51522867
63mTOR signaling pathway_Homo sapiens_hsa041500.51434627
64Melanogenesis_Homo sapiens_hsa049160.50350293
65Glioma_Homo sapiens_hsa052140.49361152
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48900468
67Phenylalanine metabolism_Homo sapiens_hsa003600.48054102
68Circadian entrainment_Homo sapiens_hsa047130.47560713
69Dorso-ventral axis formation_Homo sapiens_hsa043200.47090931
70Arginine biosynthesis_Homo sapiens_hsa002200.46090577
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.45987905
72Chronic myeloid leukemia_Homo sapiens_hsa052200.45139940
73Endometrial cancer_Homo sapiens_hsa052130.45106920
74Pentose phosphate pathway_Homo sapiens_hsa000300.44710234
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44523603
76MAPK signaling pathway_Homo sapiens_hsa040100.44106193
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43544196
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42845720
79Non-small cell lung cancer_Homo sapiens_hsa052230.41499352
80Insulin secretion_Homo sapiens_hsa049110.41486700
81Salivary secretion_Homo sapiens_hsa049700.41185498
82Cholinergic synapse_Homo sapiens_hsa047250.40037952
83Fatty acid metabolism_Homo sapiens_hsa012120.39048609
84HIF-1 signaling pathway_Homo sapiens_hsa040660.38595592
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37307522
86Ovarian steroidogenesis_Homo sapiens_hsa049130.36305443
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.34165151
88Regulation of autophagy_Homo sapiens_hsa041400.31641778
89Parkinsons disease_Homo sapiens_hsa050120.31234465
90Endocytosis_Homo sapiens_hsa041440.29314028
91VEGF signaling pathway_Homo sapiens_hsa043700.28255760
92Inositol phosphate metabolism_Homo sapiens_hsa005620.26823816
93Starch and sucrose metabolism_Homo sapiens_hsa005000.26603371
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26016009
95Small cell lung cancer_Homo sapiens_hsa052220.25887094
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25431705
97Protein digestion and absorption_Homo sapiens_hsa049740.25226866
98B cell receptor signaling pathway_Homo sapiens_hsa046620.24408232
99MicroRNAs in cancer_Homo sapiens_hsa052060.23668468
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.23540516

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