ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	9.44244080
2	regulation of skeletal muscle contraction (GO:0014819)	9.42698990
3	actin-myosin filament sliding (GO:0033275)	9.32007906
4	muscle filament sliding (GO:0030049)	9.32007906
5	plasma membrane repair (GO:0001778)	8.46961214
6	negative regulation of potassium ion transmembrane transport (GO:1901380)	8.40450959
7	regulation of sarcomere organization (GO:0060297)	8.19084966
8	actin-mediated cell contraction (GO:0070252)	7.85135664
9	cardiac myofibril assembly (GO:0055003)	7.80809471
10	sarcoplasmic reticulum calcium ion transport (GO:0070296)	7.80740071
11	myofibril assembly (GO:0030239)	7.70496703
12	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	7.15409213
13	sarcomere organization (GO:0045214)	7.12715634
14	negative regulation of protein localization to cell surface (GO:2000009)	6.73418798
15	response to inactivity (GO:0014854)	6.64421888
16	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	6.62562582
17	regulation of relaxation of muscle (GO:1901077)	6.49564649
18	striated muscle atrophy (GO:0014891)	6.32781983
19	actin filament-based movement (GO:0030048)	6.08602514
20	skeletal muscle contraction (GO:0003009)	6.07303368
21	response to muscle activity (GO:0014850)	5.97544589
22	positive regulation of myotube differentiation (GO:0010831)	5.77350165
23	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	5.75941315
24	striated muscle contraction (GO:0006941)	5.74869501
25	negative regulation of muscle hypertrophy (GO:0014741)	5.65877553
26	muscle atrophy (GO:0014889)	5.60606911
27	cardiac muscle contraction (GO:0060048)	5.59312786
28	muscle cell cellular homeostasis (GO:0046716)	5.49930324
29	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	5.49738579
30	skeletal muscle adaptation (GO:0043501)	5.42258927
31	actomyosin structure organization (GO:0031032)	5.36229373
32	regulation of cell communication by electrical coupling (GO:0010649)	5.20465091
33	negative regulation of nitric-oxide synthase activity (GO:0051001)	5.14110053
34	regulation of actin filament-based movement (GO:1903115)	5.05505652
35	cardiac muscle hypertrophy (GO:0003300)	4.90420581
36	regulation of membrane repolarization (GO:0060306)	4.90280890
37	cardiac muscle cell development (GO:0055013)	4.86145482
38	striated muscle adaptation (GO:0014888)	4.82411910
39	ventricular cardiac muscle cell action potential (GO:0086005)	4.79441682
40	negative regulation of cardiac muscle hypertrophy (GO:0010614)	4.70792759
41	striated muscle hypertrophy (GO:0014897)	4.65466563
42	skeletal muscle tissue regeneration (GO:0043403)	4.64644097
43	regulation of striated muscle contraction (GO:0006942)	4.53788505
44	cardiac cell development (GO:0055006)	4.53175221
45	negative regulation of cardiac muscle tissue growth (GO:0055022)	4.49129431
46	negative regulation of heart growth (GO:0061117)	4.49129431
47	myoblast fusion (GO:0007520)	4.48728204
48	heart contraction (GO:0060047)	4.46962271
49	heart process (GO:0003015)	4.46962271
50	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	4.43939633
51	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	4.41066971
52	skeletal muscle fiber development (GO:0048741)	4.32664349
53	membrane raft organization (GO:0031579)	4.27643525
54	muscle contraction (GO:0006936)	4.17462129
55	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	4.17086211
56	cardiac muscle tissue morphogenesis (GO:0055008)	4.14925623
57	negative regulation of cell size (GO:0045792)	4.13872227
58	muscle hypertrophy (GO:0014896)	4.12802870
59	skeletal muscle tissue development (GO:0007519)	4.12376836
60	negative regulation of potassium ion transport (GO:0043267)	4.08827827
61	positive regulation of myoblast differentiation (GO:0045663)	4.08415451
62	muscle tissue morphogenesis (GO:0060415)	4.03292864
63	myotube cell development (GO:0014904)	4.03236574
64	positive regulation of microtubule polymerization (GO:0031116)	3.98895767
65	syncytium formation by plasma membrane fusion (GO:0000768)	3.93893169
66	muscle system process (GO:0003012)	3.93172699
67	regulation of p38MAPK cascade (GO:1900744)	3.85577378
68	muscle cell fate commitment (GO:0042693)	3.84829935
69	regulation of calcium ion transmembrane transporter activity (GO:1901019)	3.83129354
70	regulation of calcium ion transmembrane transport (GO:1903169)	3.83129354
71	negative regulation of organelle assembly (GO:1902116)	3.81507911
72	muscle adaptation (GO:0043500)	3.80111217
73	regulation of cardiac muscle cell differentiation (GO:2000725)	3.75350112
74	regulation of muscle hypertrophy (GO:0014743)	3.74418279
75	heart trabecula formation (GO:0060347)	3.72812329
76	ribonucleoprotein complex disassembly (GO:0032988)	3.72308544
77	creatine metabolic process (GO:0006600)	3.70828394
78	striated muscle cell development (GO:0055002)	3.67501404
79	regulation of the force of heart contraction (GO:0002026)	3.66257345
80	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	3.66054964
81	myotube differentiation (GO:0014902)	3.61861226
82	muscle fiber development (GO:0048747)	3.60327505
83	regulation of potassium ion transmembrane transporter activity (GO:1901016)	3.57786899
84	muscle organ development (GO:0007517)	3.56368816
85	cardiac muscle adaptation (GO:0014887)	3.56349632
86	cardiac muscle hypertrophy in response to stress (GO:0014898)	3.56349632
87	muscle hypertrophy in response to stress (GO:0003299)	3.56349632
88	muscle structure development (GO:0061061)	3.53467593
89	adult heart development (GO:0007512)	3.53065536
90	regulation of action potential (GO:0098900)	3.48759334
91	cardiac muscle cell action potential (GO:0086001)	3.43276526
92	regulation of cardiac muscle contraction (GO:0055117)	3.42048589
93	relaxation of cardiac muscle (GO:0055119)	3.41963223
94	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.41826059
95	regulation of muscle adaptation (GO:0043502)	3.41533032
96	nucleus localization (GO:0051647)	3.34659514
97	regulation of cardiac muscle hypertrophy (GO:0010611)	3.34140494
98	cardiac muscle cell action potential involved in contraction (GO:0086002)	3.32521958
99	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.32126435
100	negative regulation of monooxygenase activity (GO:0032769)	3.26767883

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.89813134
2	GATA1_22025678_ChIP-Seq_K562_Human	4.62044586
3	EP300_21415370_ChIP-Seq_HL-1_Mouse	3.42499793
4	VDR_22108803_ChIP-Seq_LS180_Human	3.28754988
5	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.99457847
6	TBX20_22328084_ChIP-Seq_HEART_Mouse	2.95314168
7	TBX20_22080862_ChIP-Seq_HEART_Mouse	2.95314168
8	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.86327822
9	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.74434738
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.62410545
11	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.53205709
12	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	2.22068638
13	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.20331657
14	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.12936255
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.09002265
16	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	2.02862103
17	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.82205804
18	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.82205804
19	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.82205804
20	GATA4_21415370_ChIP-Seq_HL-1_Mouse	1.78070334
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.70029477
22	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.67205012
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.65438584
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.62577987
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.58456981
26	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.53466722
27	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.52370179
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.51170460
29	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.49961667
30	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.49194912
31	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.47958263
32	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.47725641
33	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45614944
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.45501416
35	CJUN_26792858_Chip-Seq_BT549_Human	1.45249442
36	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.41458023
37	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.40396938
38	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.40369255
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40147707
40	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.39904150
41	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.39586483
42	GBX2_23144817_ChIP-Seq_PC3_Human	1.37986164
43	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.36558480
44	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.33499117
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33260564
46	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.29134265
47	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.28505116
48	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.27738512
49	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.27738512
50	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.24745255
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22857976
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21479083
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.20902092
54	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.20542479
55	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18733762
56	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.18708339
57	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18633651
58	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.17079239
59	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.16063641
60	GATA1_19941827_ChIP-Seq_MEL86_Mouse	1.14097252
61	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13867635
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12505166
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11831585
64	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.11444910
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11426068
66	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.10417643
67	BRD4_25478319_ChIP-Seq_HGPS_Human	1.09040376
68	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08638525
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08318822
70	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.08048134
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07872850
72	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07685655
73	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07189318
74	STAT3_23295773_ChIP-Seq_U87_Human	1.07025578
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05274224
76	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03314364
77	TCF4_23295773_ChIP-Seq_U87_Human	1.02727839
78	TP53_16413492_ChIP-PET_HCT116_Human	1.02646672
79	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.01435914
80	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.99157469
81	GF1_26923725_Chip-Seq_HPCs_Mouse	0.97730750
82	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97578380
83	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.97384896
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97175747
85	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.96943435
86	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.96767698
87	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.96379720
88	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95358147
89	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.94520918
90	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.94331591
91	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.94263167
92	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.94237487
93	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.93827229
94	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.93679275
95	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.93651898
96	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.91558532
97	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.91024634
98	TAF15_26573619_Chip-Seq_HEK293_Human	0.90345354
99	PU1_27457419_Chip-Seq_LIVER_Mouse	0.89603370
100	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.88008297

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000751_myopathy	6.28315362
2	MP0000749_muscle_degeneration	6.26746779
3	MP0004084_abnormal_cardiac_muscle	5.14958889
4	MP0003950_abnormal_plasma_membrane	5.03626477
5	MP0004036_abnormal_muscle_relaxation	4.44670792
6	MP0004145_abnormal_muscle_electrophysio	4.36613101
7	MP0003646_muscle_fatigue	4.22416641
8	MP0004087_abnormal_muscle_fiber	3.33405820
9	MP0002837_dystrophic_cardiac_calcinosis	3.23364080
10	MP0005330_cardiomyopathy	3.13961535
11	MP0002106_abnormal_muscle_physiology	3.11801377
12	MP0002269_muscular_atrophy	3.00293402
13	MP0000759_abnormal_skeletal_muscle	2.95963910
14	MP0004215_abnormal_myocardial_fiber	2.86366226
15	MP0000750_abnormal_muscle_regeneration	2.73919667
16	MP0005620_abnormal_muscle_contractility	2.72858154
17	MP0000747_muscle_weakness	2.67613058
18	MP0002972_abnormal_cardiac_muscle	2.61974704
19	MP0005369_muscle_phenotype	2.59132897
20	MP0004484_altered_response_of	2.30580475
21	MP0004130_abnormal_muscle_cell	2.25727815
22	MP0002332_abnormal_exercise_endurance	2.20162277
23	MP0010630_abnormal_cardiac_muscle	2.13459829
24	MP0003828_pulmonary_edema	2.03550217
25	MP0004233_abnormal_muscle_weight	2.00223263
26	MP0006138_congestive_heart_failure	1.89371243
27	MP0005385_cardiovascular_system_phenoty	1.85053987
28	MP0001544_abnormal_cardiovascular_syste	1.85053987
29	MP0004510_myositis	1.84471815
30	MP0000733_abnormal_muscle_development	1.79982818
31	MP0002108_abnormal_muscle_morphology	1.76683375
32	MP0008775_abnormal_heart_ventricle	1.74085037
33	MP0005171_absent_coat_pigmentation	1.65238803
34	MP0000569_abnormal_digit_pigmentation	1.63808914
35	MP0005451_abnormal_body_composition	1.62062615
36	MP0002127_abnormal_cardiovascular_syste	1.58684925
37	MP0000372_irregular_coat_pigmentation	1.51675251
38	MP0003221_abnormal_cardiomyocyte_apopto	1.49876480
39	MP0004270_analgesia	1.44187114
40	MP0003137_abnormal_impulse_conducting	1.23833908
41	MP0004272_abnormal_basement_membrane	0.98600619
42	MP0008438_abnormal_cutaneous_collagen	0.97264913
43	MP0001661_extended_life_span	0.95363506
44	MP0005670_abnormal_white_adipose	0.94321142
45	MP0002971_abnormal_brown_adipose	0.92543455
46	MP0003705_abnormal_hypodermis_morpholog	0.91092220
47	MP0004085_abnormal_heartbeat	0.89784212
48	MP0003045_fibrosis	0.89418688
49	MP0005266_abnormal_metabolism	0.89065282
50	MP0000013_abnormal_adipose_tissue	0.85278687
51	MP0000266_abnormal_heart_morphology	0.83853726
52	MP0009780_abnormal_chondrocyte_physiolo	0.83096777
53	MP0006036_abnormal_mitochondrial_physio	0.82322599
54	MP0002102_abnormal_ear_morphology	0.81961257
55	MP0001958_emphysema	0.79394476
56	MP0005165_increased_susceptibility_to	0.76666326
57	MP0005187_abnormal_penis_morphology	0.75683625
58	MP0003279_aneurysm	0.75050598
59	MP0003136_yellow_coat_color	0.73487026
60	MP0005275_abnormal_skin_tensile	0.72403829
61	MP0010368_abnormal_lymphatic_system	0.72203843
62	MP0001299_abnormal_eye_distance/	0.71339204
63	MP0000015_abnormal_ear_pigmentation	0.71180645
64	MP0002877_abnormal_melanocyte_morpholog	0.69771166
65	MP0005408_hypopigmentation	0.57953360
66	MP0002128_abnormal_blood_circulation	0.57383736
67	MP0004381_abnormal_hair_follicle	0.57020576
68	MP0000767_abnormal_smooth_muscle	0.54022839
69	MP0001542_abnormal_bone_strength	0.53375619
70	MP0004883_abnormal_blood_vessel	0.52462479
71	MP0005409_darkened_coat_color	0.51689532
72	MP0005666_abnormal_adipose_tissue	0.50528100
73	MP0003091_abnormal_cell_migration	0.49794241
74	MP0002896_abnormal_bone_mineralization	0.48486877
75	MP0005375_adipose_tissue_phenotype	0.45949919
76	MP0002009_preneoplasia	0.43617134
77	MP0002095_abnormal_skin_pigmentation	0.40281950
78	MP0000003_abnormal_adipose_tissue	0.39818077
79	MP0003566_abnormal_cell_adhesion	0.39318686
80	MP0000467_abnormal_esophagus_morphology	0.36819386
81	MP0004134_abnormal_chest_morphology	0.36263048
82	MP0005388_respiratory_system_phenotype	0.35060011
83	MP0002133_abnormal_respiratory_system	0.35060011
84	MP0004185_abnormal_adipocyte_glucose	0.34914131
85	MP0005623_abnormal_meninges_morphology	0.31583116
86	MP0005174_abnormal_tail_pigmentation	0.31040266
87	MP0001879_abnormal_lymphatic_vessel	0.28943296
88	MP0002114_abnormal_axial_skeleton	0.28417433
89	MP0010030_abnormal_orbit_morphology	0.28199607
90	MP0005376_homeostasis/metabolism_phenot	0.28121398
91	MP0000371_diluted_coat_color	0.27809362
92	MP0005503_abnormal_tendon_morphology	0.27122330
93	MP0005166_decreased_susceptibility_to	0.26920675
94	MP0000230_abnormal_systemic_arterial	0.26316392
95	MP0003763_abnormal_thymus_physiology	0.26112849
96	MP0003385_abnormal_body_wall	0.25050619
97	MP0001915_intracranial_hemorrhage	0.24976699
98	MP0009115_abnormal_fat_cell	0.23588199
99	MP0008770_decreased_survivor_rate	0.21203123
100	MP0002925_abnormal_cardiovascular_devel	0.21193157

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Exercise-induced myalgia (HP:0003738)	8.16808521
2	Calf muscle hypertrophy (HP:0008981)	8.08240061
3	Nemaline bodies (HP:0003798)	8.04202977
4	Muscle hypertrophy of the lower extremities (HP:0008968)	7.76290994
5	Muscle fiber inclusion bodies (HP:0100299)	7.76114867
6	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	7.75741436
7	Exercise-induced muscle cramps (HP:0003710)	7.74693714
8	Abnormality of the left ventricular outflow tract (HP:0011103)	6.70780502
9	Subaortic stenosis (HP:0001682)	6.70780502
10	Sudden death (HP:0001699)	6.68176160
11	Type 1 muscle fiber predominance (HP:0003803)	6.40197149
12	Asymmetric septal hypertrophy (HP:0001670)	5.85197575
13	Abnormality of the calf musculature (HP:0001430)	5.78080224
14	Hyporeflexia of lower limbs (HP:0002600)	5.60671619
15	Neck muscle weakness (HP:0000467)	4.93763194
16	Distal arthrogryposis (HP:0005684)	4.82055486
17	Distal lower limb muscle weakness (HP:0009053)	4.76030031
18	Muscle fiber splitting (HP:0003555)	4.45385936
19	EMG: myopathic abnormalities (HP:0003458)	4.39553400
20	Bundle branch block (HP:0011710)	4.09239375
21	Round ear (HP:0100830)	4.04669733
22	Myotonia (HP:0002486)	4.00977538
23	Muscle stiffness (HP:0003552)	3.88268735
24	Myopathic facies (HP:0002058)	3.78625541
25	Ulnar deviation of the wrist (HP:0003049)	3.70058306
26	Gowers sign (HP:0003391)	3.63041726
27	Difficulty running (HP:0009046)	3.48182317
28	Rhabdomyolysis (HP:0003201)	3.46598735
29	Myoglobinuria (HP:0002913)	3.41256064
30	Centrally nucleated skeletal muscle fibers (HP:0003687)	3.31977070
31	Abnormality of skeletal muscle fiber size (HP:0012084)	3.30896507
32	Rimmed vacuoles (HP:0003805)	3.30073809
33	Increased connective tissue (HP:0009025)	3.27442675
34	Areflexia of lower limbs (HP:0002522)	3.24788942
35	Lipoatrophy (HP:0100578)	3.22223672
36	Calcaneovalgus deformity (HP:0001848)	3.21173706
37	EMG: neuropathic changes (HP:0003445)	3.15930182
38	Popliteal pterygium (HP:0009756)	3.15916320
39	Increased variability in muscle fiber diameter (HP:0003557)	3.06259263
40	Ventricular arrhythmia (HP:0004308)	3.03387563
41	Ventricular tachycardia (HP:0004756)	3.01362438
42	Malignant hyperthermia (HP:0002047)	2.96048540
43	Fetal akinesia sequence (HP:0001989)	2.86474758
44	Fatigable weakness (HP:0003473)	2.83099876
45	Abnormality of the neuromuscular junction (HP:0003398)	2.83099876
46	Deformed tarsal bones (HP:0008119)	2.82900786
47	Frequent falls (HP:0002359)	2.82804295
48	Dilated cardiomyopathy (HP:0001644)	2.78052934
49	Weak cry (HP:0001612)	2.76915788
50	Absent phalangeal crease (HP:0006109)	2.76670571
51	Atrial fibrillation (HP:0005110)	2.74571518
52	Type 2 muscle fiber atrophy (HP:0003554)	2.72719796
53	Prolonged QT interval (HP:0001657)	2.63672979
54	Scapular winging (HP:0003691)	2.57738884
55	Distal lower limb amyotrophy (HP:0008944)	2.51596544
56	Generalized muscle weakness (HP:0003324)	2.48172495
57	Primary atrial arrhythmia (HP:0001692)	2.40023272
58	Abnormal finger flexion creases (HP:0006143)	2.39538316
59	Arterial tortuosity (HP:0005116)	2.32977680
60	Muscle fiber atrophy (HP:0100295)	2.31736270
61	Heart block (HP:0012722)	2.31378209
62	Supraventricular tachycardia (HP:0004755)	2.28335024
63	Mildly elevated creatine phosphokinase (HP:0008180)	2.25514854
64	Supraventricular arrhythmia (HP:0005115)	2.22601495
65	Bulbar palsy (HP:0001283)	2.21670284
66	Aortic aneurysm (HP:0004942)	2.21003611
67	Abnormal atrioventricular conduction (HP:0005150)	2.19872091
68	Metatarsus adductus (HP:0001840)	2.14557540
69	Vascular tortuosity (HP:0004948)	2.14499144
70	Limb-girdle muscle atrophy (HP:0003797)	2.12462115
71	Amniotic constriction ring (HP:0009775)	2.09927162
72	Abnormality of placental membranes (HP:0011409)	2.09927162
73	Syncope (HP:0001279)	2.04505277
74	Abnormality of the foot musculature (HP:0001436)	2.03814295
75	Hip contracture (HP:0003273)	2.03335404
76	Steppage gait (HP:0003376)	2.02881846
77	Lower limb amyotrophy (HP:0007210)	2.01551789
78	Atrioventricular block (HP:0001678)	1.90612862
79	Foot dorsiflexor weakness (HP:0009027)	1.89854661
80	Left ventricular hypertrophy (HP:0001712)	1.87780614
81	Proximal amyotrophy (HP:0007126)	1.87597292
82	Abnormal EKG (HP:0003115)	1.86293476
83	Spinal rigidity (HP:0003306)	1.83724091
84	Protrusio acetabuli (HP:0003179)	1.83296191
85	Right ventricular cardiomyopathy (HP:0011663)	1.82616252
86	Abnormality of the shoulder girdle musculature (HP:0001435)	1.82051438
87	Nonprogressive disorder (HP:0003680)	1.79934312
88	Abnormality of the calcaneus (HP:0008364)	1.77642238
89	Muscular dystrophy (HP:0003560)	1.75802311
90	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.75237069
91	Aplasia of the musculature (HP:0100854)	1.74921145
92	Ventricular fibrillation (HP:0001663)	1.70861251
93	Easy fatigability (HP:0003388)	1.69827872
94	Renal cortical cysts (HP:0000803)	1.69138233
95	Palpitations (HP:0001962)	1.62181514
96	Waddling gait (HP:0002515)	1.59899805
97	Long clavicles (HP:0000890)	1.59162551
98	Slender build (HP:0001533)	1.58607693
99	Limited hip movement (HP:0008800)	1.58054296
100	Difficulty climbing stairs (HP:0003551)	1.57895541

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OBSCN	9.10939435
2	TTN	5.10808805
3	MUSK	4.41014219
4	PIK3CG	3.92684239
5	PHKG1	3.37301497
6	PHKG2	3.37301497
7	DMPK	3.13007980
8	MAP3K7	2.73025064
9	MAPKAPK5	2.64266793
10	CCNB1	2.41445065
11	MAPK12	2.02461930
12	CDK8	1.95205406
13	MYLK	1.59099451
14	SCYL2	1.51196236
15	MAP2K3	1.51179380
16	TRPM7	1.46667288
17	MOS	1.46553025
18	NEK9	1.37291121
19	PIK3CA	1.17551002
20	PINK1	1.16955402
21	MAPK7	1.16878303
22	MELK	1.07504825
23	PRKAA2	0.99460379
24	MAP3K10	0.98757214
25	CAMK2D	0.95816003
26	MARK2	0.94622804
27	EEF2K	0.89243897
28	PAK6	0.88861637
29	MAPKAPK3	0.82933278
30	PDK2	0.82556114
31	SGK2	0.81810453
32	MARK1	0.75698310
33	TGFBR2	0.72630431
34	SGK3	0.72243866
35	PRKACB	0.69482129
36	MAPK4	0.65951327
37	CAMK2G	0.65375416
38	BLK	0.63111018
39	MAP2K1	0.62563961
40	PRKAA1	0.58850647
41	PAK3	0.56341977
42	CDK9	0.55774867
43	CAMK4	0.53274589
44	ROCK1	0.52530981
45	STK4	0.52380434
46	PAK2	0.50693435
47	CAMK2A	0.49671578
48	PRKD1	0.48903800
49	MAP2K4	0.48340768
50	CDK4	0.47886062
51	PRKG1	0.47779564
52	LIMK1	0.45636691
53	MAP3K6	0.45341588
54	CAMK2B	0.43975866
55	AKT2	0.43534530
56	CAMK1	0.43259579
57	MAP3K5	0.43170288
58	DDR2	0.40167126
59	NEK1	0.39724807
60	STK38L	0.38338156
61	ERBB3	0.38027743
62	KSR2	0.36974311
63	FGFR3	0.36269824
64	MTOR	0.35512239
65	NLK	0.35309496
66	BRD4	0.35209071
67	MARK3	0.33669175
68	RPS6KA3	0.33457359
69	TIE1	0.33163883
70	ROCK2	0.33152095
71	ZAP70	0.32170356
72	STK24	0.32153070
73	EIF2AK3	0.31772831
74	MAP3K3	0.31143863
75	FGFR1	0.30811962
76	PKN1	0.30450144
77	SGK494	0.29905155
78	SGK223	0.29905155
79	PDGFRA	0.29859522
80	CDC42BPA	0.29345710
81	FER	0.29262210
82	RPS6KB1	0.29073842
83	LATS1	0.28758853
84	JAK1	0.28414539
85	MAPK10	0.28249277
86	CSNK1D	0.27328472
87	RIPK1	0.26977483
88	MAPK11	0.25853353
89	PRKACA	0.25729876
90	SGK1	0.25184790
91	WNK1	0.24324404
92	PRPF4B	0.24114761
93	PKN2	0.22163476
94	MAP3K13	0.19906816
95	EPHA3	0.19023812
96	PRKACG	0.17882240
97	PDK1	0.17055787
98	EPHB1	0.16905682
99	PDGFRB	0.16536845
100	SYK	0.16280651

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	5.38772062
2	Dilated cardiomyopathy_Homo sapiens_hsa05414	5.18152047
3	Cardiac muscle contraction_Homo sapiens_hsa04260	3.95256559
4	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	3.66097366
5	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	2.67368009
6	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.54539109
7	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.30708176
8	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.18929515
9	Circadian rhythm_Homo sapiens_hsa04710	1.95292912
10	Pyruvate metabolism_Homo sapiens_hsa00620	1.95238696
11	Viral myocarditis_Homo sapiens_hsa05416	1.84396175
12	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.76187679
13	Focal adhesion_Homo sapiens_hsa04510	1.72864602
14	Propanoate metabolism_Homo sapiens_hsa00640	1.69233388
15	Glucagon signaling pathway_Homo sapiens_hsa04922	1.65910758
16	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.60316218
17	Insulin signaling pathway_Homo sapiens_hsa04910	1.56866487
18	Insulin resistance_Homo sapiens_hsa04931	1.51272063
19	Calcium signaling pathway_Homo sapiens_hsa04020	1.45222932
20	Adherens junction_Homo sapiens_hsa04520	1.43983696
21	Lysine degradation_Homo sapiens_hsa00310	1.39411976
22	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.35924203
23	Fatty acid degradation_Homo sapiens_hsa00071	1.34294968
24	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.33202336
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14630405
26	Tight junction_Homo sapiens_hsa04530	1.14571734
27	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.13976443
28	Arginine and proline metabolism_Homo sapiens_hsa00330	1.13478212
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.13123176
30	Carbon metabolism_Homo sapiens_hsa01200	1.12959251
31	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.11257115
32	Renin secretion_Homo sapiens_hsa04924	1.11042009
33	AMPK signaling pathway_Homo sapiens_hsa04152	1.09853949
34	Histidine metabolism_Homo sapiens_hsa00340	1.01992477
35	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.01509307
36	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.99836283
37	Proteoglycans in cancer_Homo sapiens_hsa05205	0.99800040
38	FoxO signaling pathway_Homo sapiens_hsa04068	0.97834307
39	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.94995917
40	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.94722284
41	Pancreatic secretion_Homo sapiens_hsa04972	0.88334003
42	Gastric acid secretion_Homo sapiens_hsa04971	0.88310094
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.87353792
44	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.85661139
45	ECM-receptor interaction_Homo sapiens_hsa04512	0.83896390
46	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.79069525
47	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.78085842
48	Amoebiasis_Homo sapiens_hsa05146	0.78049357
49	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.76387362
50	Colorectal cancer_Homo sapiens_hsa05210	0.75377089
51	Platelet activation_Homo sapiens_hsa04611	0.74041869
52	GnRH signaling pathway_Homo sapiens_hsa04912	0.71992627
53	Long-term potentiation_Homo sapiens_hsa04720	0.70890823
54	Renal cell carcinoma_Homo sapiens_hsa05211	0.70452147
55	cAMP signaling pathway_Homo sapiens_hsa04024	0.69937163
56	Pancreatic cancer_Homo sapiens_hsa05212	0.68768419
57	ABC transporters_Homo sapiens_hsa02010	0.68555889
58	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.65432044
59	Alzheimers disease_Homo sapiens_hsa05010	0.62813804
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.58312626
61	Gap junction_Homo sapiens_hsa04540	0.55422729
62	PPAR signaling pathway_Homo sapiens_hsa03320	0.51522867
63	mTOR signaling pathway_Homo sapiens_hsa04150	0.51434627
64	Melanogenesis_Homo sapiens_hsa04916	0.50350293
65	Glioma_Homo sapiens_hsa05214	0.49361152
66	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.48900468
67	Phenylalanine metabolism_Homo sapiens_hsa00360	0.48054102
68	Circadian entrainment_Homo sapiens_hsa04713	0.47560713
69	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47090931
70	Arginine biosynthesis_Homo sapiens_hsa00220	0.46090577
71	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.45987905
72	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.45139940
73	Endometrial cancer_Homo sapiens_hsa05213	0.45106920
74	Pentose phosphate pathway_Homo sapiens_hsa00030	0.44710234
75	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.44523603
76	MAPK signaling pathway_Homo sapiens_hsa04010	0.44106193
77	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.43544196
78	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.42845720
79	Non-small cell lung cancer_Homo sapiens_hsa05223	0.41499352
80	Insulin secretion_Homo sapiens_hsa04911	0.41486700
81	Salivary secretion_Homo sapiens_hsa04970	0.41185498
82	Cholinergic synapse_Homo sapiens_hsa04725	0.40037952
83	Fatty acid metabolism_Homo sapiens_hsa01212	0.39048609
84	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.38595592
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.37307522
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.36305443
87	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.34165151
88	Regulation of autophagy_Homo sapiens_hsa04140	0.31641778
89	Parkinsons disease_Homo sapiens_hsa05012	0.31234465
90	Endocytosis_Homo sapiens_hsa04144	0.29314028
91	VEGF signaling pathway_Homo sapiens_hsa04370	0.28255760
92	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.26823816
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.26603371
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.26016009
95	Small cell lung cancer_Homo sapiens_hsa05222	0.25887094
96	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.25431705
97	Protein digestion and absorption_Homo sapiens_hsa04974	0.25226866
98	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.24408232
99	MicroRNAs in cancer_Homo sapiens_hsa05206	0.23668468
100	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.23540516

ZNF106

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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