ZNF107

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing multiple C2H2-type zinc finger regions. Proteins containing zinc fingers may act as transcriptional regulators, but may also have other cellular functions. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.24882569
2mitotic sister chromatid cohesion (GO:0007064)4.50110692
3histone mRNA catabolic process (GO:0071044)4.47933980
4V(D)J recombination (GO:0033151)4.25285867
5nuclear pore complex assembly (GO:0051292)4.24697593
6protein K6-linked ubiquitination (GO:0085020)4.17244540
7nuclear pore organization (GO:0006999)4.02042281
8DNA replication checkpoint (GO:0000076)3.94522882
9negative regulation of DNA-dependent DNA replication (GO:2000104)3.87836152
10regulation of centriole replication (GO:0046599)3.82313469
11somatic diversification of immune receptors via somatic mutation (GO:0002566)3.80828167
12somatic hypermutation of immunoglobulin genes (GO:0016446)3.80828167
13regulation of mitotic spindle checkpoint (GO:1903504)3.70043733
14regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.70043733
15histone mRNA metabolic process (GO:0008334)3.61090371
16somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.58961378
17somatic cell DNA recombination (GO:0016444)3.58961378
18regulation of histone H3-K9 methylation (GO:0051570)3.58069211
19DNA double-strand break processing (GO:0000729)3.58027766
20regulation of nuclear cell cycle DNA replication (GO:0033262)3.57146852
21regulation of DNA endoreduplication (GO:0032875)3.45469402
22ncRNA catabolic process (GO:0034661)3.44650972
23neural tube formation (GO:0001841)3.44000502
24chromatin remodeling at centromere (GO:0031055)3.42295241
25somatic diversification of immune receptors (GO:0002200)3.40080705
26DNA strand elongation involved in DNA replication (GO:0006271)3.37187900
27DNA replication-dependent nucleosome assembly (GO:0006335)3.36925610
28DNA replication-dependent nucleosome organization (GO:0034723)3.36925610
29replication fork processing (GO:0031297)3.35024157
30CENP-A containing nucleosome assembly (GO:0034080)3.27516888
31regulation of helicase activity (GO:0051095)3.25369209
32monoubiquitinated protein deubiquitination (GO:0035520)3.24927435
33DNA strand elongation (GO:0022616)3.23936456
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.21042493
35negative regulation of translation, ncRNA-mediated (GO:0040033)3.21042493
36regulation of translation, ncRNA-mediated (GO:0045974)3.21042493
37maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.18390619
38replicative senescence (GO:0090399)3.17367702
39regulation of centrosome cycle (GO:0046605)3.17179431
40microtubule anchoring (GO:0034453)3.16689489
41kinetochore organization (GO:0051383)3.14553991
42telomere maintenance via semi-conservative replication (GO:0032201)3.12656262
43microtubule polymerization or depolymerization (GO:0031109)3.10662615
44histone H2A acetylation (GO:0043968)3.10121440
45postreplication repair (GO:0006301)3.08280856
46pteridine-containing compound biosynthetic process (GO:0042559)3.07918157
47regulation of centrosome duplication (GO:0010824)3.07747719
48pore complex assembly (GO:0046931)3.07236377
49snRNA transcription (GO:0009301)3.04661277
50telomere maintenance via recombination (GO:0000722)3.03303890
51double-strand break repair via homologous recombination (GO:0000724)3.02857788
52recombinational repair (GO:0000725)3.02262656
53meiotic chromosome segregation (GO:0045132)2.98178407
54somatic recombination of immunoglobulin gene segments (GO:0016447)2.97614661
55negative regulation of DNA recombination (GO:0045910)2.97468082
56determination of adult lifespan (GO:0008340)2.96724727
57sister chromatid segregation (GO:0000819)2.96696051
58histone-serine phosphorylation (GO:0035404)2.96580027
59DNA replication-independent nucleosome organization (GO:0034724)2.94602843
60DNA replication-independent nucleosome assembly (GO:0006336)2.94602843
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.93732402
62DNA ligation (GO:0006266)2.92859167
63protein localization to kinetochore (GO:0034501)2.91175848
64regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90582361
65regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90582361
66positive regulation of mitotic sister chromatid separation (GO:1901970)2.89471910
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.89471910
68positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.89471910
69peptidyl-lysine trimethylation (GO:0018023)2.88786835
70mitotic recombination (GO:0006312)2.88466850
71negative regulation of mRNA processing (GO:0050686)2.85092277
72regulation of mitotic sister chromatid separation (GO:0010965)2.84312113
73regulation of mitotic sister chromatid segregation (GO:0033047)2.84312113
74regulation of sister chromatid segregation (GO:0033045)2.84312113
75protein K11-linked deubiquitination (GO:0035871)2.83661463
76DNA replication initiation (GO:0006270)2.83618857
77negative regulation of chromosome segregation (GO:0051985)2.83516944
78DNA recombination (GO:0006310)2.83039185
79somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82494471
80somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82494471
81isotype switching (GO:0045190)2.82494471
82sister chromatid cohesion (GO:0007062)2.82393844
83nucleotide-excision repair, DNA gap filling (GO:0006297)2.82164952
84negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81520651
85negative regulation of mitotic sister chromatid separation (GO:2000816)2.81520651
86negative regulation of sister chromatid segregation (GO:0033046)2.81520651
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81520651
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81520651
89regulation of chromatin silencing (GO:0031935)2.81468914
90purine nucleobase biosynthetic process (GO:0009113)2.81327263
91mitotic sister chromatid segregation (GO:0000070)2.81308314
92mRNA splice site selection (GO:0006376)2.80904223
93mitotic G2/M transition checkpoint (GO:0044818)2.80108243
94double-strand break repair via nonhomologous end joining (GO:0006303)2.78770276
95non-recombinational repair (GO:0000726)2.78770276
96hyperosmotic salinity response (GO:0042538)2.78558712
97somatic diversification of immunoglobulins (GO:0016445)2.78550658
98DNA catabolic process, exonucleolytic (GO:0000738)2.78444554
99centriole replication (GO:0007099)2.78134214
100histone exchange (GO:0043486)2.77607882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.82311640
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.49866611
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.15444394
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.22748948
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.06752544
6IGF1R_20145208_ChIP-Seq_DFB_Human2.89551389
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48129079
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47649971
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.40143940
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27735323
11ELK1_19687146_ChIP-ChIP_HELA_Human2.26059759
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.23948392
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19923266
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.15306942
15FUS_26573619_Chip-Seq_HEK293_Human2.11312379
16EWS_26573619_Chip-Seq_HEK293_Human2.09611515
17ZNF274_21170338_ChIP-Seq_K562_Hela2.05473318
18VDR_23849224_ChIP-Seq_CD4+_Human1.93022126
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.91963036
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89798091
21PADI4_21655091_ChIP-ChIP_MCF-7_Human1.84380476
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.81364094
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78440680
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75246357
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74120755
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70799836
27FOXP3_21729870_ChIP-Seq_TREG_Human1.70495343
28GATA1_22025678_ChIP-Seq_K562_Human1.69278034
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68868238
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59514227
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57469920
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51537932
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43808256
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43801810
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.41629386
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40159760
37CIITA_25753668_ChIP-Seq_RAJI_Human1.36365605
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35101029
39AR_21909140_ChIP-Seq_LNCAP_Human1.34594938
40MYC_18940864_ChIP-ChIP_HL60_Human1.34186466
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34183256
42IRF1_19129219_ChIP-ChIP_H3396_Human1.32989660
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32000732
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29854829
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29854829
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29107420
47VDR_22108803_ChIP-Seq_LS180_Human1.28281616
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26506427
49P300_19829295_ChIP-Seq_ESCs_Human1.26434803
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25466230
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24241809
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22392528
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.21546884
54ER_23166858_ChIP-Seq_MCF-7_Human1.20809530
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20504663
56SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20464374
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15237153
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14699350
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14475273
60TAF15_26573619_Chip-Seq_HEK293_Human1.13098308
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.12098084
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.10985167
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09988834
64MYB_26560356_Chip-Seq_TH2_Human1.06625212
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05998562
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05519641
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.03655785
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03226868
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02013411
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01546886
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00693335
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99406257
73MYC_22102868_ChIP-Seq_BL_Human0.96666854
74GBX2_23144817_ChIP-Seq_PC3_Human0.96473380
75NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95221739
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95217166
77CBP_20019798_ChIP-Seq_JUKART_Human0.95217166
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95027319
79SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94542864
80NANOG_16153702_ChIP-ChIP_HESCs_Human0.94527654
81PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93743401
82KDM5A_27292631_Chip-Seq_BREAST_Human0.92716415
83MYB_26560356_Chip-Seq_TH1_Human0.92401363
84CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92197705
85KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91755609
86NFE2_27457419_Chip-Seq_LIVER_Mouse0.90705174
87STAT3_23295773_ChIP-Seq_U87_Human0.88133631
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88041570
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87032044
90GATA3_26560356_Chip-Seq_TH1_Human0.86601139
91STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.83839163
92IRF8_22096565_ChIP-ChIP_GC-B_Human0.83826956
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83042939
94SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82664478
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82111500
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.81696065
97SALL4_22934838_ChIP-ChIP_CD34+_Human0.81661995
98GATA3_27048872_Chip-Seq_THYMUS_Human0.81161712
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80670849
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80558653

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.73084997
2MP0010094_abnormal_chromosome_stability4.29477582
3MP0008877_abnormal_DNA_methylation3.85431975
4MP0008058_abnormal_DNA_repair3.14228114
5MP0003693_abnormal_embryo_hatching3.07584068
6MP0003111_abnormal_nucleus_morphology2.91687291
7MP0002009_preneoplasia2.77511489
8MP0004957_abnormal_blastocyst_morpholog2.68217058
9MP0002396_abnormal_hematopoietic_system2.53002714
10MP0003077_abnormal_cell_cycle2.51678836
11MP0003890_abnormal_embryonic-extraembry2.43900760
12MP0006292_abnormal_olfactory_placode1.96073158
13MP0003763_abnormal_thymus_physiology1.87520141
14MP0008007_abnormal_cellular_replicative1.79955938
15MP0000569_abnormal_digit_pigmentation1.79812186
16MP0003567_abnormal_fetal_cardiomyocyte1.79609248
17MP0003787_abnormal_imprinting1.77337069
18MP0003880_abnormal_central_pattern1.72765930
19MP0009697_abnormal_copulation1.70614752
20MP0008932_abnormal_embryonic_tissue1.54407097
21MP0006072_abnormal_retinal_apoptosis1.50940347
22MP0008789_abnormal_olfactory_epithelium1.49615427
23MP0005075_abnormal_melanosome_morpholog1.49348180
24MP0001293_anophthalmia1.47703950
25MP0002138_abnormal_hepatobiliary_system1.41279735
26MP0004381_abnormal_hair_follicle1.40222086
27MP0003221_abnormal_cardiomyocyte_apopto1.39547853
28MP0002102_abnormal_ear_morphology1.39208827
29MP0002006_tumorigenesis1.37808008
30MP0003718_maternal_effect1.37326649
31MP0010307_abnormal_tumor_latency1.35170909
32MP0000703_abnormal_thymus_morphology1.34927239
33MP0002166_altered_tumor_susceptibility1.26958823
34MP0002751_abnormal_autonomic_nervous1.23828101
35MP0009278_abnormal_bone_marrow1.21415752
36MP0001800_abnormal_humoral_immune1.19524757
37MP0005499_abnormal_olfactory_system1.18348027
38MP0005394_taste/olfaction_phenotype1.18348027
39MP0001697_abnormal_embryo_size1.17451470
40MP0002398_abnormal_bone_marrow1.15635188
41MP0001835_abnormal_antigen_presentation1.14416249
42MP0001188_hyperpigmentation1.13964048
43MP0000350_abnormal_cell_proliferation1.13828079
44MP0000689_abnormal_spleen_morphology1.12942350
45MP0000383_abnormal_hair_follicle1.12200008
46MP0005380_embryogenesis_phenotype1.10366135
47MP0001672_abnormal_embryogenesis/_devel1.10366135
48MP0001730_embryonic_growth_arrest1.08653193
49MP0003786_premature_aging1.07598628
50MP0005423_abnormal_somatic_nervous1.04297470
51MP0003121_genomic_imprinting1.02663243
52MP0002084_abnormal_developmental_patter1.02127325
53MP0004197_abnormal_fetal_growth/weight/1.01906563
54MP0009703_decreased_birth_body1.00317790
55MP0002088_abnormal_embryonic_growth/wei0.98475727
56MP0003984_embryonic_growth_retardation0.97425519
57MP0004133_heterotaxia0.97409145
58MP0009672_abnormal_birth_weight0.96720399
59MP0002722_abnormal_immune_system0.96178107
60MP0000313_abnormal_cell_death0.95960235
61MP0002019_abnormal_tumor_incidence0.95721855
62MP0001929_abnormal_gametogenesis0.95449684
63MP0004808_abnormal_hematopoietic_stem0.95191755
64MP0000427_abnormal_hair_cycle0.93923683
65MP0006035_abnormal_mitochondrial_morpho0.93647992
66MP0005220_abnormal_exocrine_pancreas0.93050609
67MP0003943_abnormal_hepatobiliary_system0.92933769
68MP0000631_abnormal_neuroendocrine_gland0.92429398
69MP0002210_abnormal_sex_determination0.91834893
70MP0003937_abnormal_limbs/digits/tail_de0.91587262
71MP0005253_abnormal_eye_physiology0.89058318
72MP0010352_gastrointestinal_tract_polyps0.88648830
73MP0002085_abnormal_embryonic_tissue0.88045062
74MP0001145_abnormal_male_reproductive0.86808933
75MP0002163_abnormal_gland_morphology0.86204748
76MP0001119_abnormal_female_reproductive0.86167097
77MP0001286_abnormal_eye_development0.84015020
78MP0005387_immune_system_phenotype0.82292854
79MP0001790_abnormal_immune_system0.82292854
80MP0000653_abnormal_sex_gland0.81250479
81MP0000716_abnormal_immune_system0.80616193
82MP0001986_abnormal_taste_sensitivity0.78813461
83MP0005391_vision/eye_phenotype0.74336382
84MP0002086_abnormal_extraembryonic_tissu0.72598361
85MP0002080_prenatal_lethality0.71497664
86MP0010678_abnormal_skin_adnexa0.71120952
87MP0000490_abnormal_crypts_of0.70057982
88MP0005671_abnormal_response_to0.69918864
89MP0002429_abnormal_blood_cell0.68870465
90MP0000685_abnormal_immune_system0.68081736
91MP0005645_abnormal_hypothalamus_physiol0.67981925
92MP0002420_abnormal_adaptive_immunity0.67725847
93MP0002452_abnormal_antigen_presenting0.66941786
94MP0001819_abnormal_immune_cell0.66316663
95MP0008995_early_reproductive_senescence0.66037333
96MP0005551_abnormal_eye_electrophysiolog0.65296806
97MP0001529_abnormal_vocalization0.64630451
98MP0005310_abnormal_salivary_gland0.64175579
99MP0005266_abnormal_metabolism0.63247119
100MP0001177_atelectasis0.63161323

Predicted human phenotypes

RankGene SetZ-score
1Carpal bone hypoplasia (HP:0001498)4.60274301
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.56993693
3Chromsome breakage (HP:0040012)4.20225263
4B lymphocytopenia (HP:0010976)3.80435908
5Abnormality of B cell number (HP:0010975)3.66229917
6Abnormality of chromosome stability (HP:0003220)3.52644262
7Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.48513776
8Amyotrophic lateral sclerosis (HP:0007354)3.39522642
9Hip dysplasia (HP:0001385)3.34825978
10Panhypogammaglobulinemia (HP:0003139)3.24336191
11Severe combined immunodeficiency (HP:0004430)3.00451008
12Chronic hepatic failure (HP:0100626)2.99767149
13Aplasia/Hypoplasia of the uvula (HP:0010293)2.95273460
14Abnormality of the labia minora (HP:0012880)2.94154644
15Abnormality of the lower motor neuron (HP:0002366)2.92503006
16Birth length less than 3rd percentile (HP:0003561)2.89084803
17Thyroiditis (HP:0100646)2.78236144
18Pancreatic cysts (HP:0001737)2.74947260
19Meckel diverticulum (HP:0002245)2.73728836
20Colon cancer (HP:0003003)2.72871048
21Abnormality of the preputium (HP:0100587)2.72550334
22Combined immunodeficiency (HP:0005387)2.68047887
23Abnormality of the ileum (HP:0001549)2.66076622
24Rhabdomyosarcoma (HP:0002859)2.66076621
25Ectopic kidney (HP:0000086)2.53114274
26Abnormal lung lobation (HP:0002101)2.51994192
27Volvulus (HP:0002580)2.48605575
28Sloping forehead (HP:0000340)2.46803679
29Medulloblastoma (HP:0002885)2.39588786
30Glioma (HP:0009733)2.29119640
31Nephroblastoma (Wilms tumor) (HP:0002667)2.27649830
32T lymphocytopenia (HP:0005403)2.27414900
33Clubbing of toes (HP:0100760)2.25328939
34Pancreatic fibrosis (HP:0100732)2.22853150
35Hypoplasia of the thymus (HP:0000778)2.22839903
36Abnormality of midbrain morphology (HP:0002418)2.22827746
37Molar tooth sign on MRI (HP:0002419)2.22827746
38IgM deficiency (HP:0002850)2.22193797
39Anencephaly (HP:0002323)2.20290969
40True hermaphroditism (HP:0010459)2.18743314
41IgG deficiency (HP:0004315)2.17220564
42Embryonal renal neoplasm (HP:0011794)2.15506472
43Impulsivity (HP:0100710)2.11711671
44Neoplasm of the adrenal cortex (HP:0100641)2.10273786
45Small intestinal stenosis (HP:0012848)2.09764521
46Duodenal stenosis (HP:0100867)2.09764521
47Acute lymphatic leukemia (HP:0006721)2.09017950
48Breast carcinoma (HP:0003002)2.01906501
49Small hand (HP:0200055)1.99721860
50Stomach cancer (HP:0012126)1.98317197
51Abnormality of T cell number (HP:0011839)1.98127304
52Myelodysplasia (HP:0002863)1.97244245
53Preaxial hand polydactyly (HP:0001177)1.97157459
54Papillary thyroid carcinoma (HP:0002895)1.95534365
55Progressive inability to walk (HP:0002505)1.94403622
56Lymphoma (HP:0002665)1.91465756
57Abnormality of the duodenum (HP:0002246)1.90342524
58Neoplasm of striated muscle (HP:0009728)1.85302179
59Abnormality of the carotid arteries (HP:0005344)1.84900499
60Abnormality of the septum pellucidum (HP:0007375)1.84762895
61Nephronophthisis (HP:0000090)1.84433303
62Ependymoma (HP:0002888)1.83304152
63Atrophy/Degeneration involving motor neurons (HP:0007373)1.82962563
64Triphalangeal thumb (HP:0001199)1.82741545
65Astrocytoma (HP:0009592)1.81474864
66Abnormality of the astrocytes (HP:0100707)1.81474864
67Broad-based gait (HP:0002136)1.80239166
68Curly hair (HP:0002212)1.80183439
69Long clavicles (HP:0000890)1.80110431
70Dyskinesia (HP:0100660)1.77957879
71Abnormality of the parathyroid morphology (HP:0011766)1.77900626
72Duplicated collecting system (HP:0000081)1.77846926
73Hip contracture (HP:0003273)1.77759174
74Dandy-Walker malformation (HP:0001305)1.77720343
75Aqueductal stenosis (HP:0002410)1.76362669
76Supernumerary spleens (HP:0009799)1.74365956
77Cystic hygroma (HP:0000476)1.73104302
78IgA deficiency (HP:0002720)1.72764972
79Methylmalonic acidemia (HP:0002912)1.72436552
80Absent septum pellucidum (HP:0001331)1.72229734
81Abnormality of the renal medulla (HP:0100957)1.71631105
82Postaxial foot polydactyly (HP:0001830)1.70617239
83Absent radius (HP:0003974)1.70293103
84Patellar aplasia (HP:0006443)1.69532868
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.68316758
86Aplasia/Hypoplasia involving the musculature (HP:0001460)1.68259900
87Abnormality of the pons (HP:0007361)1.67894520
88Thyroid carcinoma (HP:0002890)1.67845191
89Cafe-au-lait spot (HP:0000957)1.65691284
90Pancreatic islet-cell hyperplasia (HP:0004510)1.65061230
91Acute myeloid leukemia (HP:0004808)1.64869513
92Spinal muscular atrophy (HP:0007269)1.64835967
93Lymphopenia (HP:0001888)1.64624669
94Horseshoe kidney (HP:0000085)1.64144085
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.63875626
96Abnormality of the renal collecting system (HP:0004742)1.63187917
97Hypoplasia of the pons (HP:0012110)1.61750065
98Barrel-shaped chest (HP:0001552)1.61458701
99Intestinal atresia (HP:0011100)1.60757281
100Cortical dysplasia (HP:0002539)1.60733299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.56808616
2MAP3K103.17416183
3ZAK3.17179307
4SRPK12.98500958
5TRIM282.83075865
6MKNK22.80707763
7BRSK22.51196555
8FRK2.48307637
9BRD42.47604038
10NLK2.31907714
11NUAK12.29735030
12PLK42.22703295
13EIF2AK32.21799601
14ACVR1B2.21506356
15MKNK12.18492528
16BMPR1B2.00294265
17TSSK61.92721905
18TTK1.81516654
19SIK31.67892423
20WEE11.56050284
21PRKD31.54442008
22PLK31.50733132
23TAF11.47824380
24ATR1.37408405
25DYRK31.36760964
26MAP3K41.35458848
27CLK11.17515489
28CHEK21.16315653
29VRK11.14243437
30MAPK131.14233956
31PBK1.11921958
32CCNB11.11146117
33ERBB31.10348802
34BCR1.07787071
35ATM1.07082166
36MST41.06677948
37TLK11.04236898
38BUB11.03704337
39WNK31.00974027
40PLK11.00396043
41RPS6KA40.97388239
42EIF2AK20.96465264
43EIF2AK10.96206577
44TGFBR10.95306936
45TEC0.90975445
46PASK0.87658961
47FGFR20.84890165
48BTK0.84679813
49TAOK30.84399940
50STK30.84064974
51MAP4K10.82582832
52STK390.76399894
53STK40.75373107
54PRKCH0.74374110
55RPS6KB20.73702445
56BLK0.70983365
57TNK20.70416314
58MELK0.67349144
59CHEK10.66447264
60ADRBK20.64364914
61CDK40.63527873
62IRAK10.62953205
63CDK60.62221187
64OXSR10.60995347
65CDK120.60809179
66CDK30.60532016
67YES10.60181221
68CDK70.58157123
69AURKB0.57050311
70TNIK0.56746066
71CDK10.55955195
72PRKD20.54692971
73MAP3K70.53847016
74AKT30.53006165
75BRSK10.52534600
76NEK10.51388348
77STK38L0.50500204
78SGK20.48918519
79CDK20.47995547
80CSNK1G10.47188719
81MARK30.46188028
82LYN0.43818695
83CSNK1A1L0.41417007
84RPS6KA50.40919256
85PRKCQ0.39859684
86DYRK1A0.39418780
87IKBKE0.37773532
88ALK0.36833845
89SYK0.36725872
90PRKDC0.36203451
91NEK20.35606288
92GRK10.35217293
93NEK60.33351699
94CSNK1D0.30096815
95FGFR10.29092639
96PIM10.28988016
97GSK3B0.27684890
98INSRR0.27281054
99STK240.26673677
100CAMK1D0.25314235

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.34167923
2DNA replication_Homo sapiens_hsa030303.83069263
3Mismatch repair_Homo sapiens_hsa034303.15926421
4Homologous recombination_Homo sapiens_hsa034403.12717090
5Primary immunodeficiency_Homo sapiens_hsa053402.93417809
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83577941
7Base excision repair_Homo sapiens_hsa034102.79684110
8Fanconi anemia pathway_Homo sapiens_hsa034602.78449502
9Cell cycle_Homo sapiens_hsa041102.68929072
10Spliceosome_Homo sapiens_hsa030402.44231281
11RNA degradation_Homo sapiens_hsa030182.41267276
12RNA transport_Homo sapiens_hsa030132.36678679
13Basal transcription factors_Homo sapiens_hsa030222.12298992
14RNA polymerase_Homo sapiens_hsa030202.11100696
15One carbon pool by folate_Homo sapiens_hsa006701.94217023
16Nucleotide excision repair_Homo sapiens_hsa034201.89109461
17Systemic lupus erythematosus_Homo sapiens_hsa053221.76948257
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69160282
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68195187
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67084980
21mRNA surveillance pathway_Homo sapiens_hsa030151.59872534
22p53 signaling pathway_Homo sapiens_hsa041151.54693143
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42871495
24Propanoate metabolism_Homo sapiens_hsa006401.39262643
25Pyrimidine metabolism_Homo sapiens_hsa002401.29126990
26Dorso-ventral axis formation_Homo sapiens_hsa043201.26766539
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23380981
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.19785682
29Lysine degradation_Homo sapiens_hsa003101.19504787
30Viral carcinogenesis_Homo sapiens_hsa052031.16495098
31Alcoholism_Homo sapiens_hsa050341.16402804
32Herpes simplex infection_Homo sapiens_hsa051681.16320648
33Protein export_Homo sapiens_hsa030601.10200080
34Colorectal cancer_Homo sapiens_hsa052101.08230821
35Thyroid cancer_Homo sapiens_hsa052161.02234066
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01875502
37Cysteine and methionine metabolism_Homo sapiens_hsa002700.99370979
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97441553
39Steroid biosynthesis_Homo sapiens_hsa001000.96261061
40Prostate cancer_Homo sapiens_hsa052150.95589787
41Epstein-Barr virus infection_Homo sapiens_hsa051690.94525418
42Measles_Homo sapiens_hsa051620.93016491
43Selenocompound metabolism_Homo sapiens_hsa004500.89889065
44Purine metabolism_Homo sapiens_hsa002300.89157460
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87441033
46MicroRNAs in cancer_Homo sapiens_hsa052060.85655567
47B cell receptor signaling pathway_Homo sapiens_hsa046620.83386381
48Hepatitis B_Homo sapiens_hsa051610.82781470
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82243015
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78183766
51Asthma_Homo sapiens_hsa053100.76668288
52Hematopoietic cell lineage_Homo sapiens_hsa046400.74178482
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73137945
54Allograft rejection_Homo sapiens_hsa053300.72204399
55Proteasome_Homo sapiens_hsa030500.70303125
56Autoimmune thyroid disease_Homo sapiens_hsa053200.68560701
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.68449449
58Graft-versus-host disease_Homo sapiens_hsa053320.68369443
59Oocyte meiosis_Homo sapiens_hsa041140.66631765
60HTLV-I infection_Homo sapiens_hsa051660.66422393
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65642639
62Type I diabetes mellitus_Homo sapiens_hsa049400.65269374
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64900029
64Regulation of autophagy_Homo sapiens_hsa041400.63465110
65T cell receptor signaling pathway_Homo sapiens_hsa046600.60593013
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59786785
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.59222803
68Butanoate metabolism_Homo sapiens_hsa006500.57526150
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54990776
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51039995
71Antigen processing and presentation_Homo sapiens_hsa046120.50442382
72Inositol phosphate metabolism_Homo sapiens_hsa005620.48817074
73FoxO signaling pathway_Homo sapiens_hsa040680.48078773
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47459601
75Phototransduction_Homo sapiens_hsa047440.47425534
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44933047
77Non-small cell lung cancer_Homo sapiens_hsa052230.44037566
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42928834
79TGF-beta signaling pathway_Homo sapiens_hsa043500.42076798
80Influenza A_Homo sapiens_hsa051640.40078677
81Viral myocarditis_Homo sapiens_hsa054160.37096127
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35632079
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33602482
84Olfactory transduction_Homo sapiens_hsa047400.32791645
85Nicotine addiction_Homo sapiens_hsa050330.32723443
86Pancreatic cancer_Homo sapiens_hsa052120.32514982
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31889794
88Endometrial cancer_Homo sapiens_hsa052130.31672522
89Melanoma_Homo sapiens_hsa052180.30987684
90Taste transduction_Homo sapiens_hsa047420.30180938
91Prolactin signaling pathway_Homo sapiens_hsa049170.29451707
92Chronic myeloid leukemia_Homo sapiens_hsa052200.26136472
93Vitamin digestion and absorption_Homo sapiens_hsa049770.25762263
94Acute myeloid leukemia_Homo sapiens_hsa052210.22673168
95Circadian rhythm_Homo sapiens_hsa047100.22360529
96Caffeine metabolism_Homo sapiens_hsa002320.21756794
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21538355
98Wnt signaling pathway_Homo sapiens_hsa043100.20960632
99Legionellosis_Homo sapiens_hsa051340.20838118
100Small cell lung cancer_Homo sapiens_hsa052220.17905600

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