ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	5.14676558
2	DNA integration (GO:0015074)	4.24498194
3	nucleobase catabolic process (GO:0046113)	4.11144767
4	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.63818673
5	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.58777036
6	presynaptic membrane assembly (GO:0097105)	3.40699957
7	intraciliary transport (GO:0042073)	3.34558754
8	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.30332877
9	neuron cell-cell adhesion (GO:0007158)	3.23159942
10	gamma-aminobutyric acid transport (GO:0015812)	3.21592464
11	ganglion development (GO:0061548)	3.16181246
12	microtubule depolymerization (GO:0007019)	3.13376381
13	axonal fasciculation (GO:0007413)	3.09729859
14	olfactory bulb development (GO:0021772)	3.09682873
15	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.98377331
16	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.98377331
17	positive regulation of macrophage activation (GO:0043032)	2.97292251
18	limb bud formation (GO:0060174)	2.93988363
19	cerebral cortex radially oriented cell migration (GO:0021799)	2.92222214
20	response to pheromone (GO:0019236)	2.88933065
21	central nervous system projection neuron axonogenesis (GO:0021952)	2.86569438
22	negative regulation of axon guidance (GO:1902668)	2.83596459
23	ribonucleoprotein complex disassembly (GO:0032988)	2.82155919
24	presynaptic membrane organization (GO:0097090)	2.81469902
25	establishment of melanosome localization (GO:0032401)	2.79409312
26	regulation of cilium movement (GO:0003352)	2.79137270
27	establishment of mitochondrion localization (GO:0051654)	2.76757971
28	spermatid nucleus differentiation (GO:0007289)	2.76713832
29	water-soluble vitamin biosynthetic process (GO:0042364)	2.76356672
30	cellular response to cholesterol (GO:0071397)	2.75362368
31	cornea development in camera-type eye (GO:0061303)	2.73701599
32	glycosphingolipid biosynthetic process (GO:0006688)	2.72723793
33	melanosome transport (GO:0032402)	2.71669069
34	neuron recognition (GO:0008038)	2.70201337
35	cilium morphogenesis (GO:0060271)	2.69799308
36	establishment of pigment granule localization (GO:0051905)	2.69015621
37	anterograde synaptic vesicle transport (GO:0048490)	2.68345784
38	neuronal action potential propagation (GO:0019227)	2.68026829
39	behavioral response to ethanol (GO:0048149)	2.67738359
40	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.65843457
41	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.65507156
42	nonmotile primary cilium assembly (GO:0035058)	2.65049254
43	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.61522090
44	pigment granule transport (GO:0051904)	2.61154767
45	synapse assembly (GO:0007416)	2.58197506
46	positive regulation of chemokine secretion (GO:0090197)	2.58042093
47	neurotransmitter-gated ion channel clustering (GO:0072578)	2.57341711
48	cullin deneddylation (GO:0010388)	2.56586075
49	cellular response to sterol (GO:0036315)	2.55989855
50	somite development (GO:0061053)	2.54777916
51	central nervous system neuron axonogenesis (GO:0021955)	2.53579032
52	intra-Golgi vesicle-mediated transport (GO:0006891)	2.53570400
53	histone H2A acetylation (GO:0043968)	2.52244459
54	resolution of meiotic recombination intermediates (GO:0000712)	2.49763737
55	neural tube formation (GO:0001841)	2.49529553
56	melanosome localization (GO:0032400)	2.47111092
57	protein localization to cilium (GO:0061512)	2.46882893
58	cilium or flagellum-dependent cell motility (GO:0001539)	2.46283909
59	epithelial cilium movement (GO:0003351)	2.46247028
60	postsynaptic membrane organization (GO:0001941)	2.44234050
61	cytoskeleton-dependent intracellular transport (GO:0030705)	2.44160889
62	preassembly of GPI anchor in ER membrane (GO:0016254)	2.44048826
63	GPI anchor metabolic process (GO:0006505)	2.43955455
64	mannosylation (GO:0097502)	2.43826771
65	cerebral cortex cell migration (GO:0021795)	2.43575420
66	head development (GO:0060322)	2.43275719
67	otic vesicle formation (GO:0030916)	2.43159586
68	acrosome reaction (GO:0007340)	2.41966390
69	cilium assembly (GO:0042384)	2.41174784
70	L-serine transport (GO:0015825)	2.41016351
71	cilium organization (GO:0044782)	2.40146163
72	establishment of protein localization to Golgi (GO:0072600)	2.39950160
73	cochlea development (GO:0090102)	2.39851701
74	pigment granule localization (GO:0051875)	2.38840826
75	microtubule-based transport (GO:0010970)	2.38701761
76	protein targeting to Golgi (GO:0000042)	2.38331663
77	photoreceptor cell maintenance (GO:0045494)	2.35465806
78	vesicle localization (GO:0051648)	2.33653981
79	C-terminal protein amino acid modification (GO:0018410)	2.33407061
80	negative regulation of DNA recombination (GO:0045910)	2.32466185
81	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.32386509
82	protein polyglutamylation (GO:0018095)	2.30965036
83	vesicle transport along microtubule (GO:0047496)	2.30444039
84	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.29528226
85	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.28657853
86	protein deneddylation (GO:0000338)	2.28149512
87	negative regulation of dendrite development (GO:2000171)	2.27187927
88	vocalization behavior (GO:0071625)	2.27070692
89	regulation of axon guidance (GO:1902667)	2.26897828
90	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.25878143
91	organelle disassembly (GO:1903008)	2.25735967
92	retinal rod cell development (GO:0046548)	2.25218759
93	auditory behavior (GO:0031223)	2.24952428
94	synaptic vesicle maturation (GO:0016188)	2.23958737
95	organelle transport along microtubule (GO:0072384)	2.22358782
96	regulation of feeding behavior (GO:0060259)	2.22262142
97	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.21677897
98	C-terminal protein lipidation (GO:0006501)	2.21253724
99	histone H2A ubiquitination (GO:0033522)	2.21096376
100	reflex (GO:0060004)	2.20995498

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.41572312
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.31336813
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.30050791
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.09056540
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.87588225
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.72249356
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.63935892
8	FUS_26573619_Chip-Seq_HEK293_Human	2.58745155
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.47507394
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.42203095
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.40995928
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.39660858
13	EWS_26573619_Chip-Seq_HEK293_Human	2.14049761
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.09668732
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07168022
16	P300_19829295_ChIP-Seq_ESCs_Human	1.91708899
17	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.88625911
18	SMAD4_21799915_ChIP-Seq_A2780_Human	1.81781504
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.81499235
20	VDR_22108803_ChIP-Seq_LS180_Human	1.81026654
21	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.80084776
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.78486000
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.77053732
24	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.76119634
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.74506930
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.73806476
27	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.71833825
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.71606467
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.71455399
30	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.68226211
31	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.67612166
32	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.65333599
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.63790503
34	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63541004
35	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.54849403
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50675624
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.48925380
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48925380
39	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.45869368
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.45765128
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.45615617
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.41697802
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39075457
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38488013
45	STAT3_23295773_ChIP-Seq_U87_Human	1.37749734
46	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.36872898
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34907949
48	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.34023481
49	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.32369732
50	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30088965
51	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.29798746
52	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.29344712
53	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.25858361
54	AR_25329375_ChIP-Seq_VCAP_Human	1.25187272
55	JUN_21703547_ChIP-Seq_K562_Human	1.24132006
56	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23368498
57	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.22115235
58	SOX9_26525672_Chip-Seq_HEART_Mouse	1.21637385
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.20978659
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.20635286
61	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.19150711
62	TCF4_23295773_ChIP-Seq_U87_Human	1.17953631
63	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17636169
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16290746
65	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.14001405
66	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.13760178
67	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.13232802
68	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.12534848
69	MYC_18940864_ChIP-ChIP_HL60_Human	1.11057993
70	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.08399649
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08124539
72	TP53_18474530_ChIP-ChIP_U2OS_Human	1.07405644
73	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07261473
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06908034
75	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.06071333
76	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.05671903
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.04693989
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04654505
79	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02305118
80	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.00808999
81	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.00372566
82	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99098680
83	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98518286
84	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.98066530
85	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.98001371
86	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.97852637
87	REST_21632747_ChIP-Seq_MESCs_Mouse	0.96789350
88	BCAT_22108803_ChIP-Seq_LS180_Human	0.96042919
89	IRF1_19129219_ChIP-ChIP_H3396_Human	0.95979362
90	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.95593860
91	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.95166318
92	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.93695303
93	POU3F1_26484290_ChIP-Seq_ESCss_Mouse	0.93363628
94	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.92899112
95	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.92774514
96	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.92375394
97	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.92169621
98	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.92131902
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91987689
100	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.91941659

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.23191086
2	MP0005187_abnormal_penis_morphology	2.76346935
3	MP0000778_abnormal_nervous_system	2.56734211
4	MP0006292_abnormal_olfactory_placode	2.49086589
5	MP0002102_abnormal_ear_morphology	2.38823245
6	MP0001984_abnormal_olfaction	2.26112319
7	MP0008789_abnormal_olfactory_epithelium	2.25476968
8	MP0002234_abnormal_pharynx_morphology	2.18960313
9	MP0005394_taste/olfaction_phenotype	2.15647754
10	MP0005499_abnormal_olfactory_system	2.15647754
11	MP0001529_abnormal_vocalization	2.12419080
12	MP0001299_abnormal_eye_distance/	2.04469202
13	MP0006276_abnormal_autonomic_nervous	1.91985173
14	MP0000569_abnormal_digit_pigmentation	1.82196660
15	MP0008877_abnormal_DNA_methylation	1.81217160
16	MP0006072_abnormal_retinal_apoptosis	1.75986144
17	MP0004270_analgesia	1.70751196
18	MP0009046_muscle_twitch	1.65934258
19	MP0003787_abnormal_imprinting	1.64444792
20	MP0002233_abnormal_nose_morphology	1.60467693
21	MP0002751_abnormal_autonomic_nervous	1.60231055
22	MP0004859_abnormal_synaptic_plasticity	1.59146127
23	MP0005253_abnormal_eye_physiology	1.52995840
24	MP0003122_maternal_imprinting	1.49068517
25	MP0000631_abnormal_neuroendocrine_gland	1.47403102
26	MP0001293_anophthalmia	1.45941000
27	MP0003136_yellow_coat_color	1.42285168
28	MP0005645_abnormal_hypothalamus_physiol	1.41647428
29	MP0005248_abnormal_Harderian_gland	1.41469852
30	MP0002184_abnormal_innervation	1.41215881
31	MP0000049_abnormal_middle_ear	1.40833944
32	MP0002736_abnormal_nociception_after	1.40618558
33	MP0003755_abnormal_palate_morphology	1.39164722
34	MP0003121_genomic_imprinting	1.38569848
35	MP0003221_abnormal_cardiomyocyte_apopto	1.36997834
36	MP0004133_heterotaxia	1.35462350
37	MP0003937_abnormal_limbs/digits/tail_de	1.34891265
38	MP0002938_white_spotting	1.31030991
39	MP0003315_abnormal_perineum_morphology	1.26358736
40	MP0000647_abnormal_sebaceous_gland	1.24369945
41	MP0002734_abnormal_mechanical_nocicepti	1.24077855
42	MP0003635_abnormal_synaptic_transmissio	1.23192325
43	MP0002272_abnormal_nervous_system	1.22091308
44	MP0005171_absent_coat_pigmentation	1.21185152
45	MP0000372_irregular_coat_pigmentation	1.18549040
46	MP0009745_abnormal_behavioral_response	1.17791790
47	MP0004811_abnormal_neuron_physiology	1.15529515
48	MP0009697_abnormal_copulation	1.15324860
49	MP0004147_increased_porphyrin_level	1.15267530
50	MP0000955_abnormal_spinal_cord	1.14574448
51	MP0004215_abnormal_myocardial_fiber	1.14182570
52	MP0002909_abnormal_adrenal_gland	1.13290792
53	MP0004885_abnormal_endolymph	1.12733176
54	MP0003567_abnormal_fetal_cardiomyocyte	1.12342451
55	MP0005670_abnormal_white_adipose	1.10193255
56	MP0001486_abnormal_startle_reflex	1.07145301
57	MP0002752_abnormal_somatic_nervous	1.07026743
58	MP0001968_abnormal_touch/_nociception	1.06890188
59	MP0003385_abnormal_body_wall	1.06506680
60	MP0005551_abnormal_eye_electrophysiolog	1.06229612
61	MP0003861_abnormal_nervous_system	1.05831473
62	MP0002572_abnormal_emotion/affect_behav	1.05641997
63	MP0005391_vision/eye_phenotype	1.04327152
64	MP0002638_abnormal_pupillary_reflex	1.03056723
65	MP0002067_abnormal_sensory_capabilities	1.02369006
66	MP0002557_abnormal_social/conspecific_i	1.02365154
67	MP0002882_abnormal_neuron_morphology	1.02076005
68	MP0002063_abnormal_learning/memory/cond	1.00727281
69	MP0002064_seizures	1.00066810
70	MP0000026_abnormal_inner_ear	0.98669965
71	MP0003950_abnormal_plasma_membrane	0.98350807
72	MP0005386_behavior/neurological_phenoty	0.98145660
73	MP0004924_abnormal_behavior	0.98145660
74	MP0004142_abnormal_muscle_tone	0.97992502
75	MP0009053_abnormal_anal_canal	0.97758384
76	MP0002653_abnormal_ependyma_morphology	0.97423812
77	MP0002928_abnormal_bile_duct	0.96824528
78	MP0003119_abnormal_digestive_system	0.96576940
79	MP0002735_abnormal_chemical_nociception	0.96215227
80	MP0003935_abnormal_craniofacial_develop	0.95851790
81	MP0002697_abnormal_eye_size	0.93564713
82	MP0002177_abnormal_outer_ear	0.92766589
83	MP0005195_abnormal_posterior_eye	0.92576126
84	MP0002152_abnormal_brain_morphology	0.92537802
85	MP0002160_abnormal_reproductive_system	0.89968107
86	MP0000427_abnormal_hair_cycle	0.89802128
87	MP0005423_abnormal_somatic_nervous	0.88097827
88	MP0001286_abnormal_eye_development	0.87591544
89	MP0001986_abnormal_taste_sensitivity	0.86637770
90	MP0000566_synostosis	0.86075312
91	MP0010368_abnormal_lymphatic_system	0.85351495
92	MP0003890_abnormal_embryonic-extraembry	0.80761459
93	MP0001188_hyperpigmentation	0.80757290
94	MP0002282_abnormal_trachea_morphology	0.79483815
95	MP0001177_atelectasis	0.78754459
96	MP0003698_abnormal_male_reproductive	0.78447885
97	MP0000383_abnormal_hair_follicle	0.78104338
98	MP0008058_abnormal_DNA_repair	0.74972495
99	MP0003011_delayed_dark_adaptation	0.73332991
100	MP0004085_abnormal_heartbeat	0.71550764

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nephrogenic diabetes insipidus (HP:0009806)	3.80962050
2	Gait imbalance (HP:0002141)	3.80532940
3	Congenital primary aphakia (HP:0007707)	3.73739543
4	Medial flaring of the eyebrow (HP:0010747)	3.57718838
5	Cortical dysplasia (HP:0002539)	3.44330584
6	True hermaphroditism (HP:0010459)	3.31677917
7	Pancreatic fibrosis (HP:0100732)	3.05276787
8	Chronic hepatic failure (HP:0100626)	3.00642568
9	Vaginal atresia (HP:0000148)	2.97478287
10	Nephronophthisis (HP:0000090)	2.96225926
11	Genital tract atresia (HP:0001827)	2.92181575
12	Occipital encephalocele (HP:0002085)	2.90358329
13	Pancreatic cysts (HP:0001737)	2.87197614
14	Abnormality of the labia minora (HP:0012880)	2.83762159
15	Drooling (HP:0002307)	2.71823306
16	Poor coordination (HP:0002370)	2.69552998
17	Abnormality of the renal medulla (HP:0100957)	2.57937694
18	Abnormality of midbrain morphology (HP:0002418)	2.55641824
19	Molar tooth sign on MRI (HP:0002419)	2.55641824
20	Decreased testicular size (HP:0008734)	2.46949233
21	Lissencephaly (HP:0001339)	2.46400386
22	Retinal dysplasia (HP:0007973)	2.39261251
23	Excessive salivation (HP:0003781)	2.37651790
24	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.31241127
25	Failure to thrive in infancy (HP:0001531)	2.28991224
26	Postaxial hand polydactyly (HP:0001162)	2.26965875
27	Broad foot (HP:0001769)	2.26373399
28	Specific learning disability (HP:0001328)	2.21486488
29	Papillary thyroid carcinoma (HP:0002895)	2.19862061
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.17935140
31	Abnormality of alanine metabolism (HP:0010916)	2.17935140
32	Hyperalaninemia (HP:0003348)	2.17935140
33	Hip dysplasia (HP:0001385)	2.17290727
34	Hyperventilation (HP:0002883)	2.15511914
35	Postaxial foot polydactyly (HP:0001830)	2.14596668
36	Renal dysplasia (HP:0000110)	2.11750590
37	Aplasia/Hypoplasia of the lens (HP:0008063)	2.11355533
38	Optic nerve hypoplasia (HP:0000609)	2.10657450
39	Absent speech (HP:0001344)	2.09552378
40	Pachygyria (HP:0001302)	2.08827137
41	Polyphagia (HP:0002591)	2.07237666
42	Focal motor seizures (HP:0011153)	2.07175169
43	Type II lissencephaly (HP:0007260)	2.06456861
44	Astigmatism (HP:0000483)	2.06098116
45	Polymicrogyria (HP:0002126)	2.00340781
46	Tubulointerstitial nephritis (HP:0001970)	1.98323024
47	Short foot (HP:0001773)	1.96824873
48	Hypsarrhythmia (HP:0002521)	1.94108443
49	Septo-optic dysplasia (HP:0100842)	1.92585105
50	Pheochromocytoma (HP:0002666)	1.90807995
51	Generalized myoclonic seizures (HP:0002123)	1.90766988
52	Methylmalonic acidemia (HP:0002912)	1.87882480
53	Micropenis (HP:0000054)	1.87506961
54	EEG with generalized epileptiform discharges (HP:0011198)	1.87478512
55	Follicular hyperkeratosis (HP:0007502)	1.86986910
56	Abnormality of the metopic suture (HP:0005556)	1.86564974
57	Cerebellar dysplasia (HP:0007033)	1.86480609
58	Abnormality of the renal cortex (HP:0011035)	1.85696671
59	Thyroid carcinoma (HP:0002890)	1.85661701
60	Abnormal respiratory epithelium morphology (HP:0012253)	1.85358703
61	Abnormal respiratory motile cilium morphology (HP:0005938)	1.85358703
62	Anencephaly (HP:0002323)	1.85233796
63	Epileptiform EEG discharges (HP:0011182)	1.83996855
64	Bile duct proliferation (HP:0001408)	1.83432480
65	Abnormal biliary tract physiology (HP:0012439)	1.83432480
66	Inability to walk (HP:0002540)	1.80949868
67	Sclerocornea (HP:0000647)	1.80715342
68	Volvulus (HP:0002580)	1.80537323
69	Abnormal ciliary motility (HP:0012262)	1.79425614
70	Muscular hypotonia of the trunk (HP:0008936)	1.78917554
71	Left ventricular hypertrophy (HP:0001712)	1.78868481
72	Narrow forehead (HP:0000341)	1.78800443
73	Hyperglycinemia (HP:0002154)	1.77453285
74	Progressive inability to walk (HP:0002505)	1.76196792
75	Exercise-induced muscle cramps (HP:0003710)	1.75960815
76	Preaxial hand polydactyly (HP:0001177)	1.75518280
77	Long foot (HP:0001833)	1.75285251
78	Amyotrophic lateral sclerosis (HP:0007354)	1.75273281
79	Aganglionic megacolon (HP:0002251)	1.74324939
80	Adrenal hypoplasia (HP:0000835)	1.74300318
81	Renal cortical cysts (HP:0000803)	1.74268847
82	Spastic tetraplegia (HP:0002510)	1.72641397
83	Small hand (HP:0200055)	1.72319483
84	Prominent nasal bridge (HP:0000426)	1.70742969
85	Colon cancer (HP:0003003)	1.69710746
86	Cystic liver disease (HP:0006706)	1.69222901
87	Intestinal atresia (HP:0011100)	1.68740456
88	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.68215895
89	Neuroendocrine neoplasm (HP:0100634)	1.65950244
90	Congenital hepatic fibrosis (HP:0002612)	1.65488137
91	Anterior segment dysgenesis (HP:0007700)	1.64073008
92	Supernumerary spleens (HP:0009799)	1.61967690
93	Abnormality of the lower motor neuron (HP:0002366)	1.61575296
94	Oligodactyly (hands) (HP:0001180)	1.61548284
95	Decreased muscle mass (HP:0003199)	1.60886136
96	Exotropia (HP:0000577)	1.60588176
97	Dandy-Walker malformation (HP:0001305)	1.60087562
98	Hypoplasia of the brainstem (HP:0002365)	1.60066597
99	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.60066597
100	Broad-based gait (HP:0002136)	1.60055790

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.70009242
2	BCR	3.61806946
3	TRIM28	3.33632716
4	MARK1	2.98404653
5	MAP3K4	2.92771829
6	CASK	2.76535718
7	TIE1	2.74272551
8	MAP2K7	2.60456518
9	SRPK1	2.14084645
10	EPHA4	2.09455981
11	WNK3	2.05641721
12	ERBB3	2.05394202
13	MINK1	1.91682331
14	MAPK13	1.91115317
15	CSNK1G1	1.90248417
16	CSNK1G3	1.90186846
17	CSNK1G2	1.87005416
18	DYRK2	1.85111842
19	CSNK1A1L	1.77380680
20	STK38L	1.71942745
21	CLK1	1.60453738
22	FRK	1.50933994
23	EPHB2	1.48249623
24	PAK3	1.42876433
25	PLK2	1.42666216
26	MKNK2	1.34210048
27	PINK1	1.25377385
28	PBK	1.24317884
29	RPS6KA4	1.20361803
30	NUAK1	1.20184265
31	BCKDK	1.19998721
32	MKNK1	1.11642243
33	FER	1.11120905
34	DYRK3	1.06004776
35	BUB1	1.04998473
36	BMPR1B	1.04729768
37	PLK3	1.01829089
38	PNCK	0.99251127
39	NTRK2	0.99048269
40	SIK3	0.95365120
41	AKT3	0.93049823
42	LIMK1	0.91292062
43	LATS1	0.88171834
44	MAP2K4	0.87903870
45	CDC7	0.85395746
46	CDK3	0.83754556
47	KSR1	0.81365933
48	GRK1	0.79960426
49	PRKCE	0.79082323
50	NEK1	0.77845715
51	PRKCG	0.73741005
52	PAK6	0.72058846
53	UHMK1	0.71817551
54	MAP3K6	0.71052243
55	CDK14	0.69204158
56	OBSCN	0.67431662
57	TNIK	0.65609326
58	WEE1	0.65392314
59	CDK18	0.63978084
60	ERBB4	0.63664848
61	CAMK2A	0.63154889
62	PIM2	0.60842394
63	BRSK2	0.60036104
64	PKN1	0.59611165
65	FGFR2	0.58131799
66	ATR	0.56935822
67	CAMK2B	0.56182185
68	SGK494	0.55854542
69	SGK223	0.55854542
70	PLK1	0.54626071
71	CDK5	0.54206074
72	INSRR	0.54148481
73	CSNK1A1	0.53525761
74	CDK15	0.52162980
75	BRD4	0.52100109
76	VRK1	0.52092030
77	YES1	0.50457752
78	PHKG2	0.50167563
79	PHKG1	0.50167563
80	ADRBK2	0.48396050
81	TTK	0.47014093
82	NTRK3	0.46976323
83	CDK11A	0.44070748
84	DYRK1B	0.43721599
85	DYRK1A	0.41781346
86	CSNK1D	0.40037828
87	CAMK4	0.39910670
88	CSNK1E	0.39537408
89	ROCK1	0.39200290
90	ATM	0.37696498
91	SGK2	0.37447068
92	CCNB1	0.37287150
93	PRKAA1	0.37096928
94	CAMK2G	0.37035074
95	TAF1	0.36985885
96	PRKACB	0.34635633
97	OXSR1	0.34376678
98	PRKACA	0.34341959
99	RAF1	0.32975419
100	FGFR1	0.32941759

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.01747636
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.87615175
3	Nicotine addiction_Homo sapiens_hsa05033	2.86437973
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.71981034
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.61994911
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.40008806
7	Basal transcription factors_Homo sapiens_hsa03022	2.37610400
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.22087078
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.03031893
10	Propanoate metabolism_Homo sapiens_hsa00640	1.70236209
11	Butanoate metabolism_Homo sapiens_hsa00650	1.64817760
12	Phototransduction_Homo sapiens_hsa04744	1.61613875
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.58301682
14	GABAergic synapse_Homo sapiens_hsa04727	1.51200417
15	Regulation of autophagy_Homo sapiens_hsa04140	1.46775311
16	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.36636950
17	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.35782155
18	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.35709481
19	Axon guidance_Homo sapiens_hsa04360	1.33258660
20	Dopaminergic synapse_Homo sapiens_hsa04728	1.31983888
21	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.25631267
22	Hippo signaling pathway_Homo sapiens_hsa04390	1.22246785
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.15067029
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.13799978
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13375994
26	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.12946914
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.10827082
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.07964161
29	RNA polymerase_Homo sapiens_hsa03020	1.07097306
30	Cocaine addiction_Homo sapiens_hsa05030	1.06261191
31	Taste transduction_Homo sapiens_hsa04742	1.05957222
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.05562064
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01905931
34	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.01591703
35	Oocyte meiosis_Homo sapiens_hsa04114	1.00097085
36	Basal cell carcinoma_Homo sapiens_hsa05217	0.99736988
37	Collecting duct acid secretion_Homo sapiens_hsa04966	0.99135402
38	Non-homologous end-joining_Homo sapiens_hsa03450	0.98476528
39	Morphine addiction_Homo sapiens_hsa05032	0.96017199
40	Glutamatergic synapse_Homo sapiens_hsa04724	0.95296874
41	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.94439018
42	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.93726760
43	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.90463245
44	Proteasome_Homo sapiens_hsa03050	0.89393856
45	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.89185356
46	RNA degradation_Homo sapiens_hsa03018	0.87697008
47	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.85431569
48	Vibrio cholerae infection_Homo sapiens_hsa05110	0.85099649
49	Huntingtons disease_Homo sapiens_hsa05016	0.84169821
50	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.83809993
51	RNA transport_Homo sapiens_hsa03013	0.82404660
52	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.81469849
53	Amphetamine addiction_Homo sapiens_hsa05031	0.77097220
54	Parkinsons disease_Homo sapiens_hsa05012	0.76387327
55	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.75842883
56	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.75437183
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.72459421
58	Circadian entrainment_Homo sapiens_hsa04713	0.72439839
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.72373716
60	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.71182831
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.69719459
62	Circadian rhythm_Homo sapiens_hsa04710	0.69172654
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.68283115
64	Cell cycle_Homo sapiens_hsa04110	0.67644744
65	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.67453671
66	Insulin secretion_Homo sapiens_hsa04911	0.65059796
67	Serotonergic synapse_Homo sapiens_hsa04726	0.64994968
68	Cardiac muscle contraction_Homo sapiens_hsa04260	0.64704803
69	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.63383614
70	Olfactory transduction_Homo sapiens_hsa04740	0.63370491
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63189178
72	Tight junction_Homo sapiens_hsa04530	0.62970043
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.62610550
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61838561
75	Fatty acid elongation_Homo sapiens_hsa00062	0.61668171
76	Spliceosome_Homo sapiens_hsa03040	0.59578804
77	Wnt signaling pathway_Homo sapiens_hsa04310	0.56598967
78	Metabolic pathways_Homo sapiens_hsa01100	0.56029051
79	ABC transporters_Homo sapiens_hsa02010	0.52848352
80	Peroxisome_Homo sapiens_hsa04146	0.52635561
81	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.52219464
82	mRNA surveillance pathway_Homo sapiens_hsa03015	0.51924625
83	Homologous recombination_Homo sapiens_hsa03440	0.51889671
84	Nucleotide excision repair_Homo sapiens_hsa03420	0.50744913
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50690184
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.49369485
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.47862696
88	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.47034173
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46828425
90	Folate biosynthesis_Homo sapiens_hsa00790	0.46000292
91	Pyruvate metabolism_Homo sapiens_hsa00620	0.45899352
92	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.44080196
93	AMPK signaling pathway_Homo sapiens_hsa04152	0.43686525
94	Mismatch repair_Homo sapiens_hsa03430	0.43581185
95	Tryptophan metabolism_Homo sapiens_hsa00380	0.43285579
96	Alzheimers disease_Homo sapiens_hsa05010	0.43081871
97	Sulfur metabolism_Homo sapiens_hsa00920	0.42410701
98	Melanoma_Homo sapiens_hsa05218	0.42360143
99	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.41291424
100	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40959517

ZNF112

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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