ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of light stimulus involved in visual perception (GO:0050908)	4.60879094
2	detection of light stimulus involved in sensory perception (GO:0050962)	4.60879094
3	dorsal/ventral axis specification (GO:0009950)	4.46077255
4	protein heterotetramerization (GO:0051290)	4.42920708
5	water-soluble vitamin biosynthetic process (GO:0042364)	4.12490860
6	regulation of chromatin binding (GO:0035561)	4.09188500
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.03563497
8	ectoderm development (GO:0007398)	3.84833795
9	behavioral response to nicotine (GO:0035095)	3.68892230
10	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.48435867
11	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.48435867
12	protein complex biogenesis (GO:0070271)	3.45741853
13	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.38034955
14	tachykinin receptor signaling pathway (GO:0007217)	3.36398892
15	chaperone-mediated protein transport (GO:0072321)	3.33165327
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.30854987
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.30854987
18	NADH dehydrogenase complex assembly (GO:0010257)	3.30854987
19	mitochondrial respiratory chain complex assembly (GO:0033108)	3.30002777
20	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.28363096
21	DNA double-strand break processing (GO:0000729)	3.22936148
22	protein neddylation (GO:0045116)	3.20104583
23	respiratory chain complex IV assembly (GO:0008535)	3.16065402
24	spermatid development (GO:0007286)	3.10009379
25	regulation of cilium movement (GO:0003352)	3.09041094
26	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.06710640
27	response to pheromone (GO:0019236)	3.04225448
28	male sex determination (GO:0030238)	3.00930629
29	DNA replication checkpoint (GO:0000076)	2.99037766
30	ncRNA catabolic process (GO:0034661)	2.98059308
31	pre-miRNA processing (GO:0031054)	2.97367407
32	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.93798375
33	nonmotile primary cilium assembly (GO:0035058)	2.93547193
34	single strand break repair (GO:0000012)	2.90419244
35	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.89869214
36	ATP synthesis coupled proton transport (GO:0015986)	2.89869214
37	replication fork processing (GO:0031297)	2.87964960
38	rhodopsin mediated signaling pathway (GO:0016056)	2.87068518
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.85760591
40	chromatin remodeling at centromere (GO:0031055)	2.85503226
41	regulation of centriole replication (GO:0046599)	2.84257525
42	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.83320356
43	pyrimidine nucleobase catabolic process (GO:0006208)	2.82072024
44	centriole replication (GO:0007099)	2.81931578
45	ubiquinone biosynthetic process (GO:0006744)	2.81872204
46	negative regulation of telomere maintenance (GO:0032205)	2.79353764
47	fucose catabolic process (GO:0019317)	2.77681005
48	L-fucose metabolic process (GO:0042354)	2.77681005
49	L-fucose catabolic process (GO:0042355)	2.77681005
50	ubiquinone metabolic process (GO:0006743)	2.76187454
51	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.76037933
52	reciprocal DNA recombination (GO:0035825)	2.75642029
53	reciprocal meiotic recombination (GO:0007131)	2.75642029
54	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.73732713
55	DNA deamination (GO:0045006)	2.72823967
56	sperm motility (GO:0030317)	2.72752241
57	male meiosis I (GO:0007141)	2.72207075
58	cullin deneddylation (GO:0010388)	2.71873174
59	cytochrome complex assembly (GO:0017004)	2.71515370
60	sensory perception of smell (GO:0007608)	2.70349968
61	piRNA metabolic process (GO:0034587)	2.70282497
62	DNA strand renaturation (GO:0000733)	2.68943864
63	photoreceptor cell maintenance (GO:0045494)	2.66353172
64	intraciliary transport (GO:0042073)	2.65420780
65	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.61865675
66	recombinational repair (GO:0000725)	2.61642698
67	protein-cofactor linkage (GO:0018065)	2.58208858
68	double-strand break repair via homologous recombination (GO:0000724)	2.56801452
69	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.56027309
70	regulation of mitotic spindle checkpoint (GO:1903504)	2.54338353
71	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.54338353
72	synapsis (GO:0007129)	2.54249573
73	metallo-sulfur cluster assembly (GO:0031163)	2.53307879
74	iron-sulfur cluster assembly (GO:0016226)	2.53307879
75	negative regulation of appetite (GO:0032099)	2.49974794
76	negative regulation of response to food (GO:0032096)	2.49974794
77	Leydig cell differentiation (GO:0033327)	2.49967578
78	base-excision repair, AP site formation (GO:0006285)	2.48730855
79	CENP-A containing nucleosome assembly (GO:0034080)	2.48420281
80	histone exchange (GO:0043486)	2.47296299
81	meiotic chromosome segregation (GO:0045132)	2.45199387
82	vitamin catabolic process (GO:0009111)	2.44993885
83	fat-soluble vitamin catabolic process (GO:0042363)	2.44993885
84	tRNA processing (GO:0008033)	2.43841423
85	somite rostral/caudal axis specification (GO:0032525)	2.42260042
86	pseudouridine synthesis (GO:0001522)	2.42172115
87	protein deneddylation (GO:0000338)	2.42021247
88	ganglion development (GO:0061548)	2.41093876
89	electron transport chain (GO:0022900)	2.39593530
90	intracellular protein transmembrane import (GO:0044743)	2.38665633
91	regulation of mesoderm development (GO:2000380)	2.38115333
92	protein K6-linked ubiquitination (GO:0085020)	2.37749276
93	retina development in camera-type eye (GO:0060041)	2.35772830
94	nucleobase catabolic process (GO:0046113)	2.35456053
95	nucleobase biosynthetic process (GO:0046112)	2.34632806
96	respiratory electron transport chain (GO:0022904)	2.34384880
97	rRNA modification (GO:0000154)	2.33324411
98	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.32895065
99	cilium morphogenesis (GO:0060271)	2.32854438
100	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.31433939

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.06233709
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.68076240
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.62591237
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.27663548
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.16535099
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.00357718
7	VDR_22108803_ChIP-Seq_LS180_Human	2.83995363
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.83057566
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.79538916
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.69331552
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.62671475
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.51120410
13	FUS_26573619_Chip-Seq_HEK293_Human	2.21749538
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14353850
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.95898154
16	EWS_26573619_Chip-Seq_HEK293_Human	1.95403853
17	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.93405542
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.82692975
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.79321450
20	GBX2_23144817_ChIP-Seq_PC3_Human	1.75162971
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73460292
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.64038494
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.63119749
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.61771127
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61167858
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.60641773
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57153673
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56902234
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55712148
30	P300_19829295_ChIP-Seq_ESCs_Human	1.53823666
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.50870011
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.50639636
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.50585424
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.50029631
35	E2F7_22180533_ChIP-Seq_HELA_Human	1.47980211
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.45784969
37	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.45393737
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.37428384
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34448251
40	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.32307364
41	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.28719841
42	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.27777494
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.26490798
44	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.26309350
45	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.26151151
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24096483
47	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.22069046
48	FOXP3_21729870_ChIP-Seq_TREG_Human	1.21960818
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.19704662
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19704662
51	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.17970526
52	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.17277044
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16319020
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16319020
55	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.15623082
56	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.15365642
57	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.15355117
58	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11376051
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.10751263
60	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.09514932
61	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.09053810
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07763128
63	TAF15_26573619_Chip-Seq_HEK293_Human	1.06595813
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06541903
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.06476665
66	TTF2_22483619_ChIP-Seq_HELA_Human	1.05724934
67	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.05225280
68	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.04298209
69	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.04182232
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01992426
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01992426
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01866120
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01375845
74	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.00704260
75	ER_23166858_ChIP-Seq_MCF-7_Human	1.00387755
76	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.99462004
77	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.97257353
78	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96977585
79	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.93794455
80	TCF4_22108803_ChIP-Seq_LS180_Human	0.93351978
81	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.91915057
82	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.91892247
83	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91545137
84	NCOR_22424771_ChIP-Seq_293T_Human	0.90656497
85	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.90254186
86	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.89621091
87	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89433629
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89429463
89	GABP_19822575_ChIP-Seq_HepG2_Human	0.89311170
90	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.88773595
91	STAT3_23295773_ChIP-Seq_U87_Human	0.88755306
92	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.88650434
93	BCAT_22108803_ChIP-Seq_LS180_Human	0.88256990
94	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.87343622
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.86494064
96	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.86118817
97	* ERA_21632823_ChIP-Seq_H3396_Human	0.85844871
98	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85209845
99	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.85209845
100	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.85140686

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002163_abnormal_gland_morphology	3.70848591
2	MP0008789_abnormal_olfactory_epithelium	3.63117351
3	MP0005645_abnormal_hypothalamus_physiol	3.44125066
4	MP0005394_taste/olfaction_phenotype	3.06045775
5	MP0005499_abnormal_olfactory_system	3.06045775
6	MP0008877_abnormal_DNA_methylation	2.80572705
7	MP0002160_abnormal_reproductive_system	2.73248056
8	MP0003315_abnormal_perineum_morphology	2.57080032
9	MP0005379_endocrine/exocrine_gland_phen	2.35879559
10	MP0005551_abnormal_eye_electrophysiolog	2.19331034
11	MP0005410_abnormal_fertilization	2.18452829
12	MP0002653_abnormal_ependyma_morphology	2.07580776
13	MP0001542_abnormal_bone_strength	2.06922977
14	MP0006292_abnormal_olfactory_placode	2.06196351
15	MP0006276_abnormal_autonomic_nervous	2.02330751
16	MP0003890_abnormal_embryonic-extraembry	2.01934187
17	MP0008058_abnormal_DNA_repair	2.01733454
18	MP0002102_abnormal_ear_morphology	1.92323492
19	MP0003787_abnormal_imprinting	1.88352480
20	MP0003880_abnormal_central_pattern	1.87602091
21	MP0004147_increased_porphyrin_level	1.82323917
22	MP0005646_abnormal_pituitary_gland	1.79025881
23	MP0005389_reproductive_system_phenotype	1.77146606
24	MP0003136_yellow_coat_color	1.76942839
25	MP0010094_abnormal_chromosome_stability	1.76882232
26	MP0001968_abnormal_touch/_nociception	1.72590617
27	MP0002736_abnormal_nociception_after	1.66649059
28	MP0002272_abnormal_nervous_system	1.60895523
29	MP0008872_abnormal_physiological_respon	1.60006023
30	MP0003718_maternal_effect	1.59037462
31	MP0001986_abnormal_taste_sensitivity	1.49892918
32	MP0002210_abnormal_sex_determination	1.49560853
33	MP0003693_abnormal_embryo_hatching	1.45463361
34	MP0001529_abnormal_vocalization	1.42255633
35	MP0009046_muscle_twitch	1.41708894
36	MP0000778_abnormal_nervous_system	1.36482851
37	MP0003121_genomic_imprinting	1.32469662
38	MP0001929_abnormal_gametogenesis	1.31188247
39	MP0004133_heterotaxia	1.30121330
40	MP0003567_abnormal_fetal_cardiomyocyte	1.29683509
41	MP0003698_abnormal_male_reproductive	1.29390487
42	MP0004957_abnormal_blastocyst_morpholog	1.26299521
43	MP0001984_abnormal_olfaction	1.25157548
44	MP0005195_abnormal_posterior_eye	1.25133374
45	MP0006072_abnormal_retinal_apoptosis	1.23794259
46	MP0001145_abnormal_male_reproductive	1.23701064
47	MP0002233_abnormal_nose_morphology	1.23511636
48	MP0000427_abnormal_hair_cycle	1.22512026
49	MP0003878_abnormal_ear_physiology	1.21596883
50	MP0005377_hearing/vestibular/ear_phenot	1.21596883
51	MP0003119_abnormal_digestive_system	1.18816027
52	MP0001293_anophthalmia	1.17689947
53	MP0000653_abnormal_sex_gland	1.17098607
54	MP0001286_abnormal_eye_development	1.14008622
55	MP0003122_maternal_imprinting	1.13786262
56	MP0002184_abnormal_innervation	1.13768513
57	MP0002752_abnormal_somatic_nervous	1.13222913
58	MP0000647_abnormal_sebaceous_gland	1.10803725
59	MP0001485_abnormal_pinna_reflex	1.09716119
60	MP0005084_abnormal_gallbladder_morpholo	1.07477552
61	MP0003111_abnormal_nucleus_morphology	1.07401791
62	MP0002557_abnormal_social/conspecific_i	1.03622589
63	MP0003195_calcinosis	1.03016665
64	MP0009745_abnormal_behavioral_response	1.02012733
65	MP0005253_abnormal_eye_physiology	1.01883550
66	MP0004142_abnormal_muscle_tone	0.98698272
67	MP0001486_abnormal_startle_reflex	0.98127475
68	MP0008875_abnormal_xenobiotic_pharmacok	0.97737941
69	MP0001346_abnormal_lacrimal_gland	0.96334535
70	MP0002735_abnormal_chemical_nociception	0.94422143
71	MP0002254_reproductive_system_inflammat	0.92805274
72	MP0000631_abnormal_neuroendocrine_gland	0.91357528
73	MP0002572_abnormal_emotion/affect_behav	0.91008400
74	MP0001188_hyperpigmentation	0.90227722
75	MP0003123_paternal_imprinting	0.89555489
76	MP0002822_catalepsy	0.87847158
77	MP0001119_abnormal_female_reproductive	0.87808862
78	MP0003077_abnormal_cell_cycle	0.86529668
79	MP0002938_white_spotting	0.86132220
80	MP0006035_abnormal_mitochondrial_morpho	0.85163676
81	MP0002876_abnormal_thyroid_physiology	0.83937033
82	MP0001970_abnormal_pain_threshold	0.81670107
83	MP0004145_abnormal_muscle_electrophysio	0.80708421
84	MP0002733_abnormal_thermal_nociception	0.79633853
85	MP0002697_abnormal_eye_size	0.78577791
86	MP0002882_abnormal_neuron_morphology	0.78514979
87	MP0009697_abnormal_copulation	0.77923439
88	MP0003937_abnormal_limbs/digits/tail_de	0.77907416
89	MP0003646_muscle_fatigue	0.77103829
90	MP0002837_dystrophic_cardiac_calcinosis	0.76995402
91	MP0006036_abnormal_mitochondrial_physio	0.75411602
92	MP0002909_abnormal_adrenal_gland	0.75026857
93	MP0003861_abnormal_nervous_system	0.74892075
94	MP0001324_abnormal_eye_pigmentation	0.73968012
95	MP0005395_other_phenotype	0.72631952
96	MP0000372_irregular_coat_pigmentation	0.72372131
97	MP0000026_abnormal_inner_ear	0.72097569
98	MP0005174_abnormal_tail_pigmentation	0.70696546
99	MP0002734_abnormal_mechanical_nocicepti	0.70002481
100	MP0002229_neurodegeneration	0.69753302

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplasia of the uterus (HP:0000013)	4.24202080
2	Pancreatic fibrosis (HP:0100732)	3.88403217
3	Pancreatic cysts (HP:0001737)	3.88193884
4	Bony spicule pigmentary retinopathy (HP:0007737)	3.70626638
5	True hermaphroditism (HP:0010459)	3.66202575
6	Aplasia/hypoplasia of the uterus (HP:0008684)	3.59403368
7	Sex reversal (HP:0012245)	3.37437296
8	Abnormal sex determination (HP:0012244)	3.37437296
9	Molar tooth sign on MRI (HP:0002419)	3.25897857
10	Abnormality of midbrain morphology (HP:0002418)	3.25897857
11	Congenital stationary night blindness (HP:0007642)	3.18766859
12	Abnormality of the labia minora (HP:0012880)	3.17172893
13	Increased hepatocellular lipid droplets (HP:0006565)	3.13597909
14	Rib fusion (HP:0000902)	3.11449580
15	Lipid accumulation in hepatocytes (HP:0006561)	2.98923385
16	Nephronophthisis (HP:0000090)	2.92592954
17	Medial flaring of the eyebrow (HP:0010747)	2.91228198
18	Hyperglycinemia (HP:0002154)	2.79115846
19	Pendular nystagmus (HP:0012043)	2.74468627
20	Type II lissencephaly (HP:0007260)	2.71475139
21	Male pseudohermaphroditism (HP:0000037)	2.69692365
22	Sclerocornea (HP:0000647)	2.60599856
23	Decreased central vision (HP:0007663)	2.59855255
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.59602165
25	Mitochondrial inheritance (HP:0001427)	2.59337635
26	Abnormality of renal resorption (HP:0011038)	2.58611636
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.55307560
28	Acute necrotizing encephalopathy (HP:0006965)	2.49803530
29	Attenuation of retinal blood vessels (HP:0007843)	2.48195481
30	Progressive cerebellar ataxia (HP:0002073)	2.47287531
31	Increased CSF lactate (HP:0002490)	2.46390948
32	Cystic liver disease (HP:0006706)	2.44974101
33	Cerebellar dysplasia (HP:0007033)	2.42731619
34	Methylmalonic acidemia (HP:0002912)	2.41192564
35	Gait imbalance (HP:0002141)	2.40762119
36	Abnormal number of erythroid precursors (HP:0012131)	2.38514963
37	Abnormality of the renal medulla (HP:0100957)	2.33970912
38	Renal Fanconi syndrome (HP:0001994)	2.31250642
39	Congenital primary aphakia (HP:0007707)	2.31212403
40	Abolished electroretinogram (ERG) (HP:0000550)	2.30621350
41	Abnormal mitochondria in muscle tissue (HP:0008316)	2.29965936
42	Anencephaly (HP:0002323)	2.29742609
43	Acute encephalopathy (HP:0006846)	2.29125133
44	Methylmalonic aciduria (HP:0012120)	2.27112198
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.26533878
46	Abnormality of cells of the erythroid lineage (HP:0012130)	2.26411245
47	Colon cancer (HP:0003003)	2.20738267
48	Abnormality of the ileum (HP:0001549)	2.15037567
49	Increased intramyocellular lipid droplets (HP:0012240)	2.13030566
50	Tubular atrophy (HP:0000092)	2.07988370
51	Nephrogenic diabetes insipidus (HP:0009806)	2.07162439
52	Osteomalacia (HP:0002749)	2.05897803
53	Gaze-evoked nystagmus (HP:0000640)	2.05777715
54	Reticulocytopenia (HP:0001896)	2.05230507
55	Abnormality of glycine metabolism (HP:0010895)	2.04807807
56	Abnormality of serine family amino acid metabolism (HP:0010894)	2.04807807
57	Meckel diverticulum (HP:0002245)	2.03579556
58	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.02999317
59	Absent thumb (HP:0009777)	2.01842719
60	Lissencephaly (HP:0001339)	2.00119300
61	Astigmatism (HP:0000483)	1.99608980
62	Concave nail (HP:0001598)	1.99137073
63	Hepatocellular necrosis (HP:0001404)	1.97907601
64	Progressive macrocephaly (HP:0004481)	1.96548266
65	Abnormality of the renal cortex (HP:0011035)	1.96258221
66	Genital tract atresia (HP:0001827)	1.93956423
67	Vaginal atresia (HP:0000148)	1.92632248
68	Chronic hepatic failure (HP:0100626)	1.92001990
69	Sloping forehead (HP:0000340)	1.90487322
70	Septo-optic dysplasia (HP:0100842)	1.90057908
71	Polyphagia (HP:0002591)	1.89174584
72	Birth length less than 3rd percentile (HP:0003561)	1.89070550
73	Increased serum lactate (HP:0002151)	1.89010930
74	Abnormal drinking behavior (HP:0030082)	1.87368551
75	Polydipsia (HP:0001959)	1.87368551
76	Chorioretinal atrophy (HP:0000533)	1.86642055
77	Hypoplasia of the brainstem (HP:0002365)	1.85280103
78	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.85280103
79	Occipital encephalocele (HP:0002085)	1.84134167
80	Dandy-Walker malformation (HP:0001305)	1.83526763
81	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.80282758
82	Retinitis pigmentosa (HP:0000510)	1.80102844
83	Optic disc pallor (HP:0000543)	1.79382683
84	Postaxial foot polydactyly (HP:0001830)	1.79281632
85	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.79157281
86	Congenital hepatic fibrosis (HP:0002612)	1.78826802
87	Optic nerve hypoplasia (HP:0000609)	1.78465501
88	Ectopic kidney (HP:0000086)	1.77173958
89	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.77057271
90	Gonadal dysgenesis (HP:0000133)	1.76708581
91	Hypoplasia of the pons (HP:0012110)	1.76488000
92	Hyperglycinuria (HP:0003108)	1.75207799
93	Patellar aplasia (HP:0006443)	1.75094148
94	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.75051615
95	Genetic anticipation (HP:0003743)	1.74371334
96	Poor coordination (HP:0002370)	1.73695248
97	Abnormality of the pons (HP:0007361)	1.72533853
98	Preaxial hand polydactyly (HP:0001177)	1.71812373
99	Neoplasm of the adrenal cortex (HP:0100641)	1.70545447
100	Myokymia (HP:0002411)	1.70132500

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	4.09138959
2	STK39	3.57293896
3	ZAK	3.29505480
4	FRK	2.75171782
5	OXSR1	2.35791682
6	NUAK1	2.29410172
7	WNK3	2.14573535
8	VRK2	2.06225472
9	TNIK	1.95918856
10	MAP2K7	1.94237892
11	BMPR1B	1.94186693
12	ADRBK2	1.90280074
13	MAP4K2	1.86473613
14	MAP3K4	1.84417520
15	MKNK2	1.81310965
16	VRK1	1.77556050
17	GRK1	1.76436252
18	CDC7	1.76399641
19	MST4	1.74770848
20	TRIM28	1.68009400
21	BUB1	1.63790488
22	PLK3	1.60021788
23	PLK4	1.56823169
24	NEK1	1.49870969
25	DYRK2	1.42406721
26	PRKCG	1.38457793
27	BCR	1.36362433
28	NEK2	1.35605990
29	TTK	1.35408062
30	SRPK1	1.34588121
31	TSSK6	1.30219891
32	TAF1	1.26065246
33	STK16	1.22177664
34	PLK1	1.21910800
35	BRSK2	1.20560606
36	PBK	1.18940105
37	MINK1	1.14855807
38	MAPK13	1.14599823
39	CASK	1.13614183
40	MKNK1	1.13602740
41	INSRR	1.13036402
42	TLK1	1.03446704
43	ACVR1B	1.02030060
44	DYRK3	1.01550859
45	PINK1	0.99530029
46	WEE1	0.96912129
47	PNCK	0.91635757
48	PRKD3	0.91509399
49	EPHB2	0.89350836
50	ATR	0.83405750
51	TIE1	0.81775954
52	CHEK2	0.81696389
53	CSNK1G2	0.80529629
54	CSNK1G3	0.78863849
55	CSNK1G1	0.76918331
56	TXK	0.74248954
57	PRKCE	0.73817104
58	MAPK15	0.71672697
59	DAPK2	0.69108003
60	ADRBK1	0.68520207
61	NME1	0.68108697
62	RPS6KA2	0.67828986
63	CSNK1A1	0.67331945
64	EIF2AK3	0.66233908
65	AURKA	0.65754334
66	CSNK1A1L	0.65447000
67	CDK19	0.64935437
68	STK38L	0.64004199
69	EPHA4	0.62906965
70	STK3	0.62181312
71	PAK3	0.61423511
72	CSNK1E	0.61407240
73	RPS6KA6	0.59452351
74	ATM	0.59448851
75	DAPK1	0.58509822
76	PLK2	0.57945583
77	MARK1	0.52658967
78	BRSK1	0.52553997
79	MAPKAPK3	0.51390007
80	PHKG1	0.51087701
81	PHKG2	0.51087701
82	RPS6KA4	0.48258731
83	AURKB	0.48098208
84	ERBB4	0.47887384
85	CSNK2A1	0.47654172
86	EIF2AK1	0.47433717
87	BCKDK	0.47296356
88	PRKCI	0.45434912
89	PRKACA	0.45130180
90	STK38	0.43294730
91	CSNK2A2	0.42693120
92	SIK2	0.41346369
93	CHEK1	0.40494044
94	PRKDC	0.39760258
95	RPS6KL1	0.39101805
96	RPS6KC1	0.39101805
97	MAP2K6	0.38222298
98	MAP2K4	0.38054298
99	PRKCH	0.37505065
100	CDK1	0.35773150

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.63245206
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.91064716
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.42058008
4	Homologous recombination_Homo sapiens_hsa03440	2.37795860
5	Parkinsons disease_Homo sapiens_hsa05012	2.28283619
6	Proteasome_Homo sapiens_hsa03050	2.27877220
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.16476336
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.94252936
9	Fanconi anemia pathway_Homo sapiens_hsa03460	1.87964861
10	Ribosome_Homo sapiens_hsa03010	1.86141005
11	Selenocompound metabolism_Homo sapiens_hsa00450	1.81852905
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80986206
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.79894353
14	Non-homologous end-joining_Homo sapiens_hsa03450	1.79114234
15	Protein export_Homo sapiens_hsa03060	1.78562521
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.76676771
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.73430558
18	One carbon pool by folate_Homo sapiens_hsa00670	1.72446258
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.70460677
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.69690680
21	Basal transcription factors_Homo sapiens_hsa03022	1.69550889
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.69070781
23	Huntingtons disease_Homo sapiens_hsa05016	1.67770389
24	Sulfur relay system_Homo sapiens_hsa04122	1.67397631
25	Mismatch repair_Homo sapiens_hsa03430	1.67226762
26	RNA polymerase_Homo sapiens_hsa03020	1.63060437
27	Base excision repair_Homo sapiens_hsa03410	1.55234564
28	Butanoate metabolism_Homo sapiens_hsa00650	1.54240920
29	DNA replication_Homo sapiens_hsa03030	1.45861815
30	RNA transport_Homo sapiens_hsa03013	1.43575216
31	Alzheimers disease_Homo sapiens_hsa05010	1.42969942
32	RNA degradation_Homo sapiens_hsa03018	1.42760563
33	Nicotine addiction_Homo sapiens_hsa05033	1.36552146
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.36171761
35	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.33172865
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.27138925
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.24789899
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.24112669
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.22298801
40	Olfactory transduction_Homo sapiens_hsa04740	1.20049311
41	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.18540687
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.17762454
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14039220
44	Propanoate metabolism_Homo sapiens_hsa00640	1.12912361
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.11190187
46	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.10657488
47	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.05194890
48	Collecting duct acid secretion_Homo sapiens_hsa04966	1.02051092
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98913807
50	Peroxisome_Homo sapiens_hsa04146	0.97832377
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.96450032
52	Folate biosynthesis_Homo sapiens_hsa00790	0.95231365
53	Fatty acid degradation_Homo sapiens_hsa00071	0.94256872
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.91905952
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.91153438
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.88019658
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.86883429
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.86569475
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.85807096
60	Spliceosome_Homo sapiens_hsa03040	0.85360797
61	Caffeine metabolism_Homo sapiens_hsa00232	0.82826718
62	Metabolic pathways_Homo sapiens_hsa01100	0.82819171
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82058112
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.81563553
65	Morphine addiction_Homo sapiens_hsa05032	0.79642414
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.78691886
67	Taste transduction_Homo sapiens_hsa04742	0.77554187
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.76853373
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.76544927
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76350366
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.75333939
72	Purine metabolism_Homo sapiens_hsa00230	0.74908729
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70607528
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.69548484
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69382959
76	GABAergic synapse_Homo sapiens_hsa04727	0.69053326
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.68556451
78	Fatty acid elongation_Homo sapiens_hsa00062	0.64718606
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.63475079
80	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61939300
81	Retinol metabolism_Homo sapiens_hsa00830	0.61080694
82	Glutathione metabolism_Homo sapiens_hsa00480	0.61027987
83	Basal cell carcinoma_Homo sapiens_hsa05217	0.60869013
84	Insulin secretion_Homo sapiens_hsa04911	0.60053603
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56663253
86	Cell cycle_Homo sapiens_hsa04110	0.55473669
87	Serotonergic synapse_Homo sapiens_hsa04726	0.54522955
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51515249
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50668165
90	Regulation of autophagy_Homo sapiens_hsa04140	0.50505815
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.49317250
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44878055
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44685347
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42088700
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41391398
96	Circadian entrainment_Homo sapiens_hsa04713	0.40705092
97	Hippo signaling pathway_Homo sapiens_hsa04390	0.38603368
98	ABC transporters_Homo sapiens_hsa02010	0.36410790
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.33729388
100	p53 signaling pathway_Homo sapiens_hsa04115	0.32637952

ZNF114

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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