ZNF117

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing multiple C2H2-type zinc finger motifs. Readthrough transcription occurs between this gene and the upstream endogenous retrovirus group 3 member 1 (ERV3-1) locus, and may result in additional transcript variants encoding the zinc finger protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neural tube formation (GO:0001841)5.25273417
2pyrimidine nucleobase catabolic process (GO:0006208)4.84490667
3presynaptic membrane assembly (GO:0097105)4.11003463
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.07600536
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.99673155
6negative regulation of translation, ncRNA-mediated (GO:0040033)3.99673155
7regulation of translation, ncRNA-mediated (GO:0045974)3.99673155
8presynaptic membrane organization (GO:0097090)3.63728812
9limb bud formation (GO:0060174)3.61046345
10olfactory bulb development (GO:0021772)3.54916813
11nucleobase catabolic process (GO:0046113)3.51616164
12phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.49239831
13regulation of collateral sprouting (GO:0048670)3.33282766
14somite development (GO:0061053)3.28004623
15estrogen biosynthetic process (GO:0006703)3.16169073
16interkinetic nuclear migration (GO:0022027)3.09896294
17kidney morphogenesis (GO:0060993)3.09304415
18monoubiquitinated protein deubiquitination (GO:0035520)3.06599662
19regulation of sequestering of triglyceride (GO:0010889)2.98677178
20polyol transport (GO:0015791)2.98329703
21head development (GO:0060322)2.97144865
22phospholipid homeostasis (GO:0055091)2.95138755
23positive regulation of oligodendrocyte differentiation (GO:0048714)2.94786188
24cilium or flagellum-dependent cell motility (GO:0001539)2.94757501
25forebrain neuron differentiation (GO:0021879)2.91610216
26histone H3-K4 trimethylation (GO:0080182)2.90010440
27establishment of protein localization to Golgi (GO:0072600)2.89918142
28protein prenylation (GO:0018342)2.79673289
29prenylation (GO:0097354)2.79673289
30detection of molecule of bacterial origin (GO:0032490)2.79402770
31epithelial cilium movement (GO:0003351)2.78101347
32myelin assembly (GO:0032288)2.76577337
33calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.76232481
34central nervous system projection neuron axonogenesis (GO:0021952)2.68233244
35nonmotile primary cilium assembly (GO:0035058)2.65534893
36behavioral response to nicotine (GO:0035095)2.65060757
37histone H3-K9 methylation (GO:0051567)2.63113806
38neuron cell-cell adhesion (GO:0007158)2.62632436
39negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61887389
40regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.61543630
41appendage development (GO:0048736)2.61011725
42limb development (GO:0060173)2.61011725
43protein K11-linked deubiquitination (GO:0035871)2.60656624
44regulation of MHC class II biosynthetic process (GO:0045346)2.56834089
45protein targeting to Golgi (GO:0000042)2.56452639
46central nervous system neuron axonogenesis (GO:0021955)2.55392494
47cilium movement (GO:0003341)2.55080183
48regulation of non-canonical Wnt signaling pathway (GO:2000050)2.54479510
49nucleus localization (GO:0051647)2.53457152
50regulation of oligodendrocyte differentiation (GO:0048713)2.52265544
51negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.49875583
52glucocorticoid biosynthetic process (GO:0006704)2.48433485
53regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.47634296
54cilium organization (GO:0044782)2.45490712
55negative regulation of neurotransmitter transport (GO:0051589)2.43598269
56prostate gland growth (GO:0060736)2.42375944
57response to follicle-stimulating hormone (GO:0032354)2.42203563
58embryonic epithelial tube formation (GO:0001838)2.40606498
59cilium assembly (GO:0042384)2.39635511
60peptidyl-lysine trimethylation (GO:0018023)2.38996653
61negative regulation of cAMP-mediated signaling (GO:0043951)2.38989314
62retrograde transport, vesicle recycling within Golgi (GO:0000301)2.38074907
63tachykinin receptor signaling pathway (GO:0007217)2.36952167
64microtubule anchoring (GO:0034453)2.36118465
65axoneme assembly (GO:0035082)2.35970489
66L-fucose catabolic process (GO:0042355)2.35836965
67fucose catabolic process (GO:0019317)2.35836965
68L-fucose metabolic process (GO:0042354)2.35836965
69cellular response to sterol (GO:0036315)2.35706762
70cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.35172148
71cerebellar Purkinje cell differentiation (GO:0021702)2.33429354
72regulation of pigment cell differentiation (GO:0050932)2.32901382
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.31292613
74cerebral cortex radially oriented cell migration (GO:0021799)2.31134212
75intraciliary transport (GO:0042073)2.30785550
76negative regulation of oligodendrocyte differentiation (GO:0048715)2.29089610
77histone H3-K9 modification (GO:0061647)2.28508556
78negative regulation of Rho protein signal transduction (GO:0035024)2.27814537
79hindbrain development (GO:0030902)2.27515070
80regulation of sarcomere organization (GO:0060297)2.27232920
81neurotransmitter-gated ion channel clustering (GO:0072578)2.27058848
82cilium morphogenesis (GO:0060271)2.27052145
83negative regulation of transcription regulatory region DNA binding (GO:2000678)2.26446935
84positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.26090515
85regulation of cAMP-dependent protein kinase activity (GO:2000479)2.24906807
86photoreceptor cell maintenance (GO:0045494)2.24509429
87regulation of glycogen (starch) synthase activity (GO:2000465)2.23004504
88somite rostral/caudal axis specification (GO:0032525)2.22699101
89tyrosine phosphorylation of STAT protein (GO:0007260)2.22298525
90establishment of nucleus localization (GO:0040023)2.22236202
91epithelial tube formation (GO:0072175)2.21696617
92negative regulation of mast cell activation (GO:0033004)2.21505289
93retinal cone cell development (GO:0046549)2.20923381
94synapse assembly (GO:0007416)2.20126717
95positive regulation of developmental pigmentation (GO:0048087)2.20014460
96pancreas development (GO:0031016)2.19234874
97negative regulation of neurotransmitter secretion (GO:0046929)2.17889813
98sympathetic nervous system development (GO:0048485)2.17757866
99negative chemotaxis (GO:0050919)2.17739083
100cellular response to cholesterol (GO:0071397)2.16990777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.15722775
2GBX2_23144817_ChIP-Seq_PC3_Human3.02795718
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.97086239
4IGF1R_20145208_ChIP-Seq_DFB_Human2.92145405
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.91306164
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.86828658
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.84154110
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.79110642
9ZNF274_21170338_ChIP-Seq_K562_Hela2.64116799
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46405069
11TAF15_26573619_Chip-Seq_HEK293_Human2.44859424
12VDR_22108803_ChIP-Seq_LS180_Human2.28658577
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23253657
14P300_19829295_ChIP-Seq_ESCs_Human2.12992674
15FUS_26573619_Chip-Seq_HEK293_Human2.12947327
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11880858
17EWS_26573619_Chip-Seq_HEK293_Human2.07333400
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02771385
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01781032
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.00377939
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.97653635
22ER_23166858_ChIP-Seq_MCF-7_Human1.96051847
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.85499986
24TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84834595
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.84834595
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.80544258
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76226034
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.76188541
29SMAD4_21799915_ChIP-Seq_A2780_Human1.74730362
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71531948
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69200916
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69045714
33STAT3_23295773_ChIP-Seq_U87_Human1.66070176
34TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63001851
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60591203
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.52984602
37BCAT_22108803_ChIP-Seq_LS180_Human1.52046756
38TCF4_23295773_ChIP-Seq_U87_Human1.49233351
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48715539
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.48228314
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.45462387
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45103882
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43181195
44RNF2_27304074_Chip-Seq_NSC_Mouse1.43170486
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43085554
46AR_25329375_ChIP-Seq_VCAP_Human1.42526483
47AR_21572438_ChIP-Seq_LNCaP_Human1.40420254
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39592852
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39528962
50RUNX2_22187159_ChIP-Seq_PCA_Human1.37015395
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36266599
52CBP_20019798_ChIP-Seq_JUKART_Human1.36266599
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34709101
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.31734816
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28434758
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28414493
57P53_22387025_ChIP-Seq_ESCs_Mouse1.26827583
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.20765218
59E2F1_18555785_Chip-Seq_ESCs_Mouse1.20536997
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20247073
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20055589
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.19774210
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19670593
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.19555603
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19104994
66TCF4_22108803_ChIP-Seq_LS180_Human1.18989784
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16185740
68STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15145479
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.15086171
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.14241535
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13946800
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12483454
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12483454
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11749849
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.11506442
76IRF1_19129219_ChIP-ChIP_H3396_Human1.10869814
77TP53_16413492_ChIP-PET_HCT116_Human1.10690537
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.08614371
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08487471
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08454590
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08018629
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.07749921
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.07136495
84TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05413930
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05250736
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04525500
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03973610
88REST_21632747_ChIP-Seq_MESCs_Mouse1.03609117
89SOX2_19829295_ChIP-Seq_ESCs_Human1.03571412
90NANOG_19829295_ChIP-Seq_ESCs_Human1.03571412
91KDM2B_26808549_Chip-Seq_REH_Human1.03059860
92P300_18555785_Chip-Seq_ESCs_Mouse1.02310401
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00699722
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00557633
95AHR_22903824_ChIP-Seq_MCF-7_Human0.98569809
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.97377913
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.96358134
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96271578
99RXR_22108803_ChIP-Seq_LS180_Human0.96201681
100FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95745393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.60273661
2MP0003787_abnormal_imprinting3.99253621
3MP0003122_maternal_imprinting3.04887570
4MP0003890_abnormal_embryonic-extraembry2.90091477
5MP0008877_abnormal_DNA_methylation2.82246870
6MP0003121_genomic_imprinting2.62130521
7MP0003724_increased_susceptibility_to2.44515951
8MP0006276_abnormal_autonomic_nervous2.35616035
9MP0000778_abnormal_nervous_system2.20751077
10MP0008057_abnormal_DNA_replication2.15820665
11MP0002102_abnormal_ear_morphology2.04890483
12MP0001984_abnormal_olfaction1.79354431
13MP0004130_abnormal_muscle_cell1.78273436
14MP0006292_abnormal_olfactory_placode1.76412256
15MP0003195_calcinosis1.71189129
16MP0000631_abnormal_neuroendocrine_gland1.64423899
17MP0005248_abnormal_Harderian_gland1.63418346
18MP0002822_catalepsy1.60815515
19MP0004885_abnormal_endolymph1.59009103
20MP0008995_early_reproductive_senescence1.56551948
21MP0005551_abnormal_eye_electrophysiolog1.53474744
22MP0004133_heterotaxia1.52949678
23MP0001486_abnormal_startle_reflex1.48199666
24MP0002638_abnormal_pupillary_reflex1.44924417
25MP0002909_abnormal_adrenal_gland1.43916981
26MP0005253_abnormal_eye_physiology1.42729783
27MP0003880_abnormal_central_pattern1.42150557
28MP0002653_abnormal_ependyma_morphology1.41171373
29MP0008789_abnormal_olfactory_epithelium1.40764785
30MP0005394_taste/olfaction_phenotype1.39455732
31MP0005499_abnormal_olfactory_system1.39455732
32MP0002735_abnormal_chemical_nociception1.39328936
33MP0001188_hyperpigmentation1.32721052
34MP0000647_abnormal_sebaceous_gland1.32401009
35MP0001293_anophthalmia1.30907405
36MP0002928_abnormal_bile_duct1.28045091
37MP0002938_white_spotting1.25559103
38MP0003567_abnormal_fetal_cardiomyocyte1.23725917
39MP0002971_abnormal_brown_adipose1.20676405
40MP0001286_abnormal_eye_development1.20111060
41MP0005386_behavior/neurological_phenoty1.18531603
42MP0004924_abnormal_behavior1.18531603
43MP0005174_abnormal_tail_pigmentation1.16556822
44MP0005646_abnormal_pituitary_gland1.16342633
45MP0005187_abnormal_penis_morphology1.16299373
46MP0006054_spinal_hemorrhage1.15664759
47MP0004742_abnormal_vestibular_system1.15387271
48MP0010329_abnormal_lipoprotein_level1.13326731
49MP0004142_abnormal_muscle_tone1.13086048
50MP0009115_abnormal_fat_cell1.12914711
51MP0002557_abnormal_social/conspecific_i1.12777093
52MP0001529_abnormal_vocalization1.12749704
53MP0002751_abnormal_autonomic_nervous1.10612872
54MP0002184_abnormal_innervation1.06204010
55MP0005195_abnormal_posterior_eye1.04371573
56MP0009046_muscle_twitch1.04082563
57MP0000427_abnormal_hair_cycle1.02557026
58MP0002233_abnormal_nose_morphology1.01980231
59MP0002277_abnormal_respiratory_mucosa1.01510155
60MP0001177_atelectasis1.01258520
61MP0003011_delayed_dark_adaptation1.00553725
62MP0000516_abnormal_urinary_system0.99340380
63MP0005367_renal/urinary_system_phenotyp0.99340380
64MP0001986_abnormal_taste_sensitivity0.99110846
65MP0005391_vision/eye_phenotype0.98281424
66MP0001968_abnormal_touch/_nociception0.97684820
67MP0004043_abnormal_pH_regulation0.97485236
68MP0006072_abnormal_retinal_apoptosis0.96888410
69MP0003119_abnormal_digestive_system0.96736671
70MP0005167_abnormal_blood-brain_barrier0.94062063
71MP0004883_abnormal_blood_vessel0.93985194
72MP0001485_abnormal_pinna_reflex0.93174523
73MP0002752_abnormal_somatic_nervous0.92862283
74MP0002067_abnormal_sensory_capabilities0.92258134
75MP0003937_abnormal_limbs/digits/tail_de0.91129695
76MP0003828_pulmonary_edema0.90770556
77MP0005645_abnormal_hypothalamus_physiol0.90220771
78MP0002063_abnormal_learning/memory/cond0.89886046
79MP0000955_abnormal_spinal_cord0.89230191
80MP0002132_abnormal_respiratory_system0.88284720
81MP0003632_abnormal_nervous_system0.88134533
82MP0003938_abnormal_ear_development0.87964291
83MP0005377_hearing/vestibular/ear_phenot0.87138918
84MP0003878_abnormal_ear_physiology0.87138918
85MP0002882_abnormal_neuron_morphology0.85530788
86MP0005670_abnormal_white_adipose0.84722210
87MP0000639_abnormal_adrenal_gland0.83823453
88MP0002736_abnormal_nociception_after0.82629963
89MP0003136_yellow_coat_color0.82493408
90MP0002734_abnormal_mechanical_nocicepti0.81933636
91MP0005647_abnormal_sex_gland0.80448486
92MP0005448_abnormal_energy_balance0.79927939
93MP0002876_abnormal_thyroid_physiology0.79793440
94MP0002572_abnormal_emotion/affect_behav0.79609654
95MP0003635_abnormal_synaptic_transmissio0.78685439
96MP0002152_abnormal_brain_morphology0.78622567
97MP0001324_abnormal_eye_pigmentation0.77649297
98MP0003385_abnormal_body_wall0.77630477
99MP0004484_altered_response_of0.76853317
100MP0002234_abnormal_pharynx_morphology0.75870722

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)3.71625060
2Pancreatic cysts (HP:0001737)3.51597991
3True hermaphroditism (HP:0010459)3.17501627
4Nephronophthisis (HP:0000090)3.10469464
5Pancreatic fibrosis (HP:0100732)3.01291597
6Hyperventilation (HP:0002883)2.96103250
7Abnormality of the renal medulla (HP:0100957)2.83359117
8Genital tract atresia (HP:0001827)2.78963054
9Drooling (HP:0002307)2.77447384
10Vaginal atresia (HP:0000148)2.75879120
11Abnormality of midbrain morphology (HP:0002418)2.73771671
12Molar tooth sign on MRI (HP:0002419)2.73771671
13Genetic anticipation (HP:0003743)2.71269101
14Excessive salivation (HP:0003781)2.65450536
15Medial flaring of the eyebrow (HP:0010747)2.65026364
16Hepatoblastoma (HP:0002884)2.59073117
17Thyroiditis (HP:0100646)2.59014460
18Abnormality of the renal cortex (HP:0011035)2.53404660
19Abnormality of the pubic bones (HP:0003172)2.53034348
20Papillary thyroid carcinoma (HP:0002895)2.44940777
21Progressive cerebellar ataxia (HP:0002073)2.42553016
22Stomach cancer (HP:0012126)2.39088067
23Thyroid-stimulating hormone excess (HP:0002925)2.37531179
24Gait imbalance (HP:0002141)2.35921374
25Midline defect of the nose (HP:0004122)2.35326760
26Renal cortical cysts (HP:0000803)2.28778682
27Vitreoretinal degeneration (HP:0000655)2.28471433
28Absent speech (HP:0001344)2.27174535
29Congenital primary aphakia (HP:0007707)2.25368495
30Protruding tongue (HP:0010808)2.24880191
31Febrile seizures (HP:0002373)2.20152550
32Cystic liver disease (HP:0006706)2.18043374
33Aplasia/Hypoplasia of the sternum (HP:0006714)2.16563329
34Absent/shortened dynein arms (HP:0200106)2.16262353
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.16262353
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16240763
37Cupped ear (HP:0000378)2.14770454
38Nephrogenic diabetes insipidus (HP:0009806)2.14697404
39Gaze-evoked nystagmus (HP:0000640)2.10178284
40Intestinal atresia (HP:0011100)2.06375858
41Short 4th metacarpal (HP:0010044)2.04592618
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04592618
43Tubulointerstitial nephritis (HP:0001970)2.04388942
44Attenuation of retinal blood vessels (HP:0007843)2.04097733
45Absent eyebrow (HP:0002223)2.04043089
46Aqueductal stenosis (HP:0002410)2.01456673
47Renal hypoplasia (HP:0000089)2.00898388
48Anophthalmia (HP:0000528)1.99247882
49Postaxial foot polydactyly (HP:0001830)1.93994460
50Curly hair (HP:0002212)1.93202027
51Neoplasm of the tracheobronchial system (HP:0100552)1.93169810
52Poor coordination (HP:0002370)1.92890403
53Hypoplastic iliac wings (HP:0002866)1.91941072
54Clitoromegaly (HP:0000057)1.89200136
55Thyroid carcinoma (HP:0002890)1.88194896
56Widely spaced teeth (HP:0000687)1.88128347
57Abnormal ciliary motility (HP:0012262)1.86550401
58Congenital hepatic fibrosis (HP:0002612)1.85278164
59Exotropia (HP:0000577)1.85211962
60Abolished electroretinogram (ERG) (HP:0000550)1.85116425
61Anencephaly (HP:0002323)1.83178164
62Growth hormone deficiency (HP:0000824)1.82587573
63Aplasia/Hypoplasia of the tongue (HP:0010295)1.81950671
64Postaxial hand polydactyly (HP:0001162)1.81469575
65Abnormal rod and cone electroretinograms (HP:0008323)1.81256559
66Bony spicule pigmentary retinopathy (HP:0007737)1.80097247
67Male pseudohermaphroditism (HP:0000037)1.78170071
68Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77381407
69Colon cancer (HP:0003003)1.77262108
70Abnormality of the labia minora (HP:0012880)1.75998363
71Broad-based gait (HP:0002136)1.75648086
72Acute lymphatic leukemia (HP:0006721)1.74468153
73Amyotrophic lateral sclerosis (HP:0007354)1.74412668
74Abnormal respiratory motile cilium morphology (HP:0005938)1.73850451
75Abnormal respiratory epithelium morphology (HP:0012253)1.73850451
76Short foot (HP:0001773)1.73274595
77Bifid tongue (HP:0010297)1.72734121
78Bicornuate uterus (HP:0000813)1.72111687
79Cutaneous finger syndactyly (HP:0010554)1.71723583
80Lissencephaly (HP:0001339)1.71322807
81Severe Myopia (HP:0011003)1.69692722
82Congenital stationary night blindness (HP:0007642)1.69689400
83Morphological abnormality of the middle ear (HP:0008609)1.69415119
84Hip dysplasia (HP:0001385)1.69233312
85Inability to walk (HP:0002540)1.68346705
86Tented upper lip vermilion (HP:0010804)1.67622131
87Narrow forehead (HP:0000341)1.67373896
88Portal hypertension (HP:0001409)1.66128996
89Fair hair (HP:0002286)1.66080030
90Truncal obesity (HP:0001956)1.65026467
91Alveolar cell carcinoma (HP:0006519)1.61796473
92Scrotal hypoplasia (HP:0000046)1.61598611
93Volvulus (HP:0002580)1.60960933
94Pachygyria (HP:0001302)1.60404655
95Bilateral microphthalmos (HP:0007633)1.60146773
96Micropenis (HP:0000054)1.60091367
97Tubulointerstitial abnormality (HP:0001969)1.58619209
98Stomatitis (HP:0010280)1.58127845
99Broad alveolar ridges (HP:0000187)1.57622830
100Abnormality of the ischium (HP:0003174)1.57220135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.24506427
2WNK33.00642025
3MAP3K42.63518051
4CASK2.38582597
5BCR2.24640208
6DYRK32.19082052
7AKT32.16042863
8ACVR1B2.07386148
9FGFR21.84620391
10MARK11.84350737
11BMPR1B1.82315837
12SGK21.81490869
13MAPK131.81112760
14TRIM281.79090392
15MKNK21.67161605
16NUAK11.64796165
17NTRK31.48735053
18MKNK11.38331688
19MAP2K71.36304647
20NLK1.29208888
21FLT31.28656228
22EPHA31.25990962
23TAOK31.24867808
24TNIK1.24375139
25INSRR1.23973729
26MAP2K41.22041008
27PAK31.21750388
28SGK2231.21675894
29SGK4941.21675894
30ERBB31.20614193
31ADRBK21.18953628
32MAP3K61.18310963
33PINK11.15408823
34KIT1.13108442
35YES11.11596024
36DYRK1A1.08806192
37DYRK21.08165865
38NTRK21.04475857
39KSR10.99914522
40ERBB20.95948982
41CAMKK20.95863641
42CAMK1G0.95524737
43FGFR30.91791320
44BRD40.91732908
45SGK30.91605667
46PNCK0.90691695
47CAMK1D0.86213893
48DYRK1B0.86159250
49IRAK10.85813225
50BLK0.84691874
51WNK10.84605162
52LATS10.82563614
53CDK30.81817188
54DAPK20.80649817
55GRK10.77067264
56RIPK40.76258033
57MARK20.74266601
58PIK3CA0.73775972
59TGFBR10.70543063
60STK110.70164515
61PRKCE0.70038005
62PLK20.68964296
63MAP3K20.68496448
64FES0.67231436
65CSNK1G10.66134335
66TEC0.65364117
67PIK3CG0.65147085
68CAMK40.64780711
69CSNK1G20.64681664
70IRAK40.64277598
71RPS6KA40.64100610
72BTK0.63757338
73MAP4K20.63145217
74STK38L0.62926928
75FER0.60272539
76OXSR10.58993201
77PKN20.58858465
78CSF1R0.57580006
79PRKAA20.57193723
80JAK20.56849446
81CAMK10.56623373
82SYK0.56013151
83CSNK1A1L0.54111544
84WNK40.53899391
85SIK30.53146470
86FGFR10.52612024
87EPHA40.49344790
88LYN0.48982638
89HCK0.48692246
90RET0.48597198
91SGK10.48366850
92ADRBK10.47915843
93BRSK20.47241384
94SIK20.46885471
95PRKCG0.46843219
96PTK2B0.45464957
97FGR0.44224243
98PRKAA10.43747698
99PRKACB0.42773185
100PRKG10.42423451

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11757871
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.96224055
3Nicotine addiction_Homo sapiens_hsa050331.85199655
4Butanoate metabolism_Homo sapiens_hsa006501.84037865
5Steroid biosynthesis_Homo sapiens_hsa001001.78521920
6Ovarian steroidogenesis_Homo sapiens_hsa049131.62793556
7Phototransduction_Homo sapiens_hsa047441.59093639
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.56452661
9Dorso-ventral axis formation_Homo sapiens_hsa043201.56281413
10Propanoate metabolism_Homo sapiens_hsa006401.54249384
11Fatty acid biosynthesis_Homo sapiens_hsa000611.53480201
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50575139
13Ether lipid metabolism_Homo sapiens_hsa005651.48469886
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47810172
15Morphine addiction_Homo sapiens_hsa050321.45365835
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42228963
17Linoleic acid metabolism_Homo sapiens_hsa005911.39355372
18Glutamatergic synapse_Homo sapiens_hsa047241.36057721
19Taste transduction_Homo sapiens_hsa047421.35268746
20Nitrogen metabolism_Homo sapiens_hsa009101.29240050
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27148331
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26602944
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24754912
24Circadian entrainment_Homo sapiens_hsa047131.24094774
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.23513591
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21653498
27ABC transporters_Homo sapiens_hsa020101.19296904
28Axon guidance_Homo sapiens_hsa043601.18871386
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16630824
30Dopaminergic synapse_Homo sapiens_hsa047281.16609577
31Serotonergic synapse_Homo sapiens_hsa047261.15059463
32GABAergic synapse_Homo sapiens_hsa047271.14931289
33PPAR signaling pathway_Homo sapiens_hsa033201.14584417
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12970648
35Glycerolipid metabolism_Homo sapiens_hsa005611.12391081
36Long-term depression_Homo sapiens_hsa047301.09312657
37Hedgehog signaling pathway_Homo sapiens_hsa043401.07693898
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04379896
39Fatty acid metabolism_Homo sapiens_hsa012121.03319295
40Olfactory transduction_Homo sapiens_hsa047400.99414646
41Choline metabolism in cancer_Homo sapiens_hsa052310.98024489
42Cholinergic synapse_Homo sapiens_hsa047250.97550435
43NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94427878
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.92640418
45Colorectal cancer_Homo sapiens_hsa052100.91091942
46Basal cell carcinoma_Homo sapiens_hsa052170.90212521
47Prolactin signaling pathway_Homo sapiens_hsa049170.90043889
48Fanconi anemia pathway_Homo sapiens_hsa034600.88909671
49FoxO signaling pathway_Homo sapiens_hsa040680.86555585
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.85346179
51Circadian rhythm_Homo sapiens_hsa047100.84345669
52Basal transcription factors_Homo sapiens_hsa030220.84118442
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83265288
54Platelet activation_Homo sapiens_hsa046110.82895496
55Ras signaling pathway_Homo sapiens_hsa040140.81735296
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.81335484
57Type II diabetes mellitus_Homo sapiens_hsa049300.80951346
58Regulation of autophagy_Homo sapiens_hsa041400.80884545
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79889861
60Non-homologous end-joining_Homo sapiens_hsa034500.79818216
61cAMP signaling pathway_Homo sapiens_hsa040240.78987291
62Staphylococcus aureus infection_Homo sapiens_hsa051500.78876490
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77670202
64Cocaine addiction_Homo sapiens_hsa050300.77506226
65Chemokine signaling pathway_Homo sapiens_hsa040620.77368628
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76329470
67Inositol phosphate metabolism_Homo sapiens_hsa005620.74968349
68Fat digestion and absorption_Homo sapiens_hsa049750.72938269
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72400460
70Fatty acid degradation_Homo sapiens_hsa000710.68117438
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67902705
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.67670684
73Peroxisome_Homo sapiens_hsa041460.67567777
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65034297
75Vitamin digestion and absorption_Homo sapiens_hsa049770.62145940
76Histidine metabolism_Homo sapiens_hsa003400.61003648
77Renin secretion_Homo sapiens_hsa049240.60067621
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59792540
79Endometrial cancer_Homo sapiens_hsa052130.59754357
80TGF-beta signaling pathway_Homo sapiens_hsa043500.59359977
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58094424
82Amphetamine addiction_Homo sapiens_hsa050310.57437788
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.57102377
84beta-Alanine metabolism_Homo sapiens_hsa004100.56263524
85Fatty acid elongation_Homo sapiens_hsa000620.55170055
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54260524
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.53933788
88AMPK signaling pathway_Homo sapiens_hsa041520.52570856
89Wnt signaling pathway_Homo sapiens_hsa043100.52498246
90Melanoma_Homo sapiens_hsa052180.51648829
91Malaria_Homo sapiens_hsa051440.49512685
92Oxytocin signaling pathway_Homo sapiens_hsa049210.49189499
93Non-small cell lung cancer_Homo sapiens_hsa052230.48933316
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48742662
95Rap1 signaling pathway_Homo sapiens_hsa040150.47932411
96B cell receptor signaling pathway_Homo sapiens_hsa046620.46396586
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44999265
98Complement and coagulation cascades_Homo sapiens_hsa046100.43555154
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43112068
100Renal cell carcinoma_Homo sapiens_hsa052110.42947596

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