ZNF12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)7.40767184
2monoubiquitinated protein deubiquitination (GO:0035520)5.06284083
3regulation of centriole replication (GO:0046599)5.05039217
4nuclear pore complex assembly (GO:0051292)4.99839529
5mRNA modification (GO:0016556)4.78598945
6nuclear pore organization (GO:0006999)4.30500416
7establishment of protein localization to Golgi (GO:0072600)4.22134065
8DNA double-strand break processing (GO:0000729)4.20892238
9protein targeting to Golgi (GO:0000042)4.18427452
10sister chromatid cohesion (GO:0007062)4.08050406
11retrograde transport, vesicle recycling within Golgi (GO:0000301)3.85327885
12COPII vesicle coating (GO:0048208)3.73623284
13replication fork processing (GO:0031297)3.70497749
14regulation of Rac protein signal transduction (GO:0035020)3.69653466
15prenylation (GO:0097354)3.48784300
16protein prenylation (GO:0018342)3.48784300
17acrosome assembly (GO:0001675)3.48195543
18regulation of centrosome duplication (GO:0010824)3.45382355
19mitotic G2 DNA damage checkpoint (GO:0007095)3.37701099
20pore complex assembly (GO:0046931)3.28693406
21mitotic G2/M transition checkpoint (GO:0044818)3.26643991
22positive regulation of DNA-templated transcription, initiation (GO:2000144)3.22872229
23positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.16706838
24positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.16706838
25positive regulation of mitotic sister chromatid separation (GO:1901970)3.16706838
26phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.13142249
27negative regulation of DNA-dependent DNA replication (GO:2000104)3.13109111
28meiotic chromosome segregation (GO:0045132)3.11750492
29protein localization to Golgi apparatus (GO:0034067)3.08150703
30microtubule anchoring (GO:0034453)3.06358924
31regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.00892363
32anterior/posterior axis specification, embryo (GO:0008595)2.99558266
33regulation of centrosome cycle (GO:0046605)2.98171505
34peptidyl-lysine trimethylation (GO:0018023)2.97049955
35embryonic foregut morphogenesis (GO:0048617)2.96522997
36regulation of RNA export from nucleus (GO:0046831)2.95890322
37histone mRNA catabolic process (GO:0071044)2.92032484
38pre-miRNA processing (GO:0031054)2.89909508
39positive regulation of histone H3-K4 methylation (GO:0051571)2.89471125
40positive regulation of cell size (GO:0045793)2.87284401
41genitalia morphogenesis (GO:0035112)2.84513165
42negative regulation of DNA repair (GO:0045738)2.83281880
43negative regulation of keratinocyte proliferation (GO:0010839)2.80323335
44positive regulation of macroautophagy (GO:0016239)2.79730897
45intra-Golgi vesicle-mediated transport (GO:0006891)2.78643614
46double-strand break repair via homologous recombination (GO:0000724)2.77579680
47histone H2A acetylation (GO:0043968)2.77099953
48regulation of sister chromatid cohesion (GO:0007063)2.75538988
49cerebral cortex radially oriented cell migration (GO:0021799)2.75260007
50DNA topological change (GO:0006265)2.74311858
51kinetochore organization (GO:0051383)2.73916631
52recombinational repair (GO:0000725)2.71947418
53somite rostral/caudal axis specification (GO:0032525)2.70579067
54positive regulation of T cell cytokine production (GO:0002726)2.67511451
55maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.67304777
56artery development (GO:0060840)2.66842126
57gastrulation with mouth forming second (GO:0001702)2.66515504
58mitochondrial DNA replication (GO:0006264)2.66401617
59mesenchymal cell differentiation (GO:0048762)2.65850737
60negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.64844388
61neural tube formation (GO:0001841)2.64123896
62embryonic retina morphogenesis in camera-type eye (GO:0060059)2.63424833
63postreplication repair (GO:0006301)2.63004402
64lactate metabolic process (GO:0006089)2.62315913
65positive regulation of developmental pigmentation (GO:0048087)2.60338080
66RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58556844
67protein K11-linked deubiquitination (GO:0035871)2.58442257
68regulation of telomere maintenance (GO:0032204)2.58182260
69regulation of glucokinase activity (GO:0033131)2.58125062
70regulation of hexokinase activity (GO:1903299)2.58125062
71keratinocyte development (GO:0003334)2.57854683
72cellular response to ethanol (GO:0071361)2.57407933
73regulation of meiosis I (GO:0060631)2.54769137
74ER overload response (GO:0006983)2.54702200
75regulation of clathrin-mediated endocytosis (GO:2000369)2.54242068
76regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.54074298
77histone H3-K4 trimethylation (GO:0080182)2.52232636
78early endosome to late endosome transport (GO:0045022)2.51901277
79somatic hypermutation of immunoglobulin genes (GO:0016446)2.51547185
80somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51547185
81NLS-bearing protein import into nucleus (GO:0006607)2.47996905
82peptidyl-threonine dephosphorylation (GO:0035970)2.47411813
83regulation of DNA endoreduplication (GO:0032875)2.47382231
84poly(A)+ mRNA export from nucleus (GO:0016973)2.45501481
85positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.45270711
86cellular response to sterol (GO:0036315)2.45247747
87G2 DNA damage checkpoint (GO:0031572)2.43450859
88UDP-N-acetylglucosamine metabolic process (GO:0006047)2.43298038
89DNA-dependent DNA replication (GO:0006261)2.41920964
90microtubule organizing center organization (GO:0031023)2.41763992
91negative regulation of histone methylation (GO:0031061)2.41312814
92sister chromatid segregation (GO:0000819)2.41130501
93dorsal/ventral axis specification (GO:0009950)2.39664568
94protein K6-linked ubiquitination (GO:0085020)2.39518580
95centrosome duplication (GO:0051298)2.38746295
96regulation of histone H3-K4 methylation (GO:0051569)2.38515004
97negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.38122521
98negative regulation of translation, ncRNA-mediated (GO:0040033)2.38122521
99regulation of translation, ncRNA-mediated (GO:0045974)2.38122521
100auditory receptor cell differentiation (GO:0042491)2.37674952

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human4.48311916
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.48307628
3E2F7_22180533_ChIP-Seq_HELA_Human3.06117442
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73857346
5FUS_26573619_Chip-Seq_HEK293_Human2.66157961
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.64551560
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.42339193
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42015723
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36110159
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13020544
11* ZNF274_21170338_ChIP-Seq_K562_Hela2.07687342
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00173579
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97786095
14EWS_26573619_Chip-Seq_HEK293_Human1.95705890
15FOXM1_23109430_ChIP-Seq_U2OS_Human1.92964469
16* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.92954580
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89964340
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88988411
19PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86591479
20ELK1_19687146_ChIP-ChIP_HELA_Human1.83324343
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.80485904
22GBX2_23144817_ChIP-Seq_PC3_Human1.77518774
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76985026
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.72328204
25P300_19829295_ChIP-Seq_ESCs_Human1.70645031
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69439689
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.64669669
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64653162
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.63783958
30IGF1R_20145208_ChIP-Seq_DFB_Human1.63185457
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62962651
32TAF15_26573619_Chip-Seq_HEK293_Human1.59908969
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.57871561
34ER_23166858_ChIP-Seq_MCF-7_Human1.53526354
35RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.52790093
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.50885117
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47443370
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47337581
39SMAD4_21799915_ChIP-Seq_A2780_Human1.46407542
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46358033
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.46213375
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45796409
43TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.43870524
44STAT3_23295773_ChIP-Seq_U87_Human1.42872982
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41029616
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40290532
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.40184815
48TP53_16413492_ChIP-PET_HCT116_Human1.32879284
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32716963
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.31383632
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30626637
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28290417
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27059293
54* NOTCH1_21737748_ChIP-Seq_TLL_Human1.26707320
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25074836
56E2F1_18555785_Chip-Seq_ESCs_Mouse1.23065549
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.22405723
58TCF4_23295773_ChIP-Seq_U87_Human1.21973908
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.21260112
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20965162
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20561371
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20112567
63FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.19304197
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19185979
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17374825
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.17090789
67BRD4_25478319_ChIP-Seq_HGPS_Human1.16524187
68VDR_22108803_ChIP-Seq_LS180_Human1.15432027
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.15130100
70AHR_22903824_ChIP-Seq_MCF-7_Human1.12855217
71SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12396867
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11163109
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.10387148
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10361446
75P53_22387025_ChIP-Seq_ESCs_Mouse1.09273184
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08005104
77P300_18555785_Chip-Seq_ESCs_Mouse1.07570944
78CBP_20019798_ChIP-Seq_JUKART_Human1.07564383
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07564383
80CDX2_22108803_ChIP-Seq_LS180_Human1.06257535
81SALL4_22934838_ChIP-ChIP_CD34+_Human1.06178161
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05852844
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05852844
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05198072
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04861703
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04861703
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04687318
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04259342
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04215002
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.03808121
91FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.02254994
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02244821
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.01740697
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01465008
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.01423689
96FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01085720
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.98561065
98NMYC_18555785_Chip-Seq_ESCs_Mouse0.98538506
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97616413
100AR_25329375_ChIP-Seq_VCAP_Human0.97534254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.59395685
2MP0003890_abnormal_embryonic-extraembry3.10675267
3MP0010352_gastrointestinal_tract_polyps2.45090019
4MP0010094_abnormal_chromosome_stability2.45023700
5MP0000427_abnormal_hair_cycle2.43625185
6MP0009697_abnormal_copulation2.26572649
7MP0008058_abnormal_DNA_repair2.19968566
8MP0000372_irregular_coat_pigmentation2.03774052
9MP0010307_abnormal_tumor_latency2.01577039
10MP0002396_abnormal_hematopoietic_system1.98524419
11MP0005248_abnormal_Harderian_gland1.96755343
12MP0003943_abnormal_hepatobiliary_system1.95727284
13MP0002938_white_spotting1.92870198
14MP0005408_hypopigmentation1.89980701
15MP0003077_abnormal_cell_cycle1.78264886
16MP0006054_spinal_hemorrhage1.75982249
17MP0003111_abnormal_nucleus_morphology1.75852333
18MP0000013_abnormal_adipose_tissue1.70881809
19MP0005075_abnormal_melanosome_morpholog1.67492216
20MP0000516_abnormal_urinary_system1.65799230
21MP0005367_renal/urinary_system_phenotyp1.65799230
22MP0002088_abnormal_embryonic_growth/wei1.60957672
23MP0003984_embryonic_growth_retardation1.59002824
24MP0009703_decreased_birth_body1.56798968
25MP0003935_abnormal_craniofacial_develop1.55476935
26MP0000371_diluted_coat_color1.54331911
27MP0005380_embryogenesis_phenotype1.49218169
28MP0001672_abnormal_embryogenesis/_devel1.49218169
29MP0000613_abnormal_salivary_gland1.48007851
30MP0001293_anophthalmia1.47701527
31MP0008877_abnormal_DNA_methylation1.46045804
32MP0000569_abnormal_digit_pigmentation1.45120728
33MP0003787_abnormal_imprinting1.42631058
34MP0002095_abnormal_skin_pigmentation1.42544416
35MP0003937_abnormal_limbs/digits/tail_de1.42338206
36MP0002084_abnormal_developmental_patter1.42127564
37MP0010678_abnormal_skin_adnexa1.42074855
38MP0001697_abnormal_embryo_size1.41861833
39MP0000383_abnormal_hair_follicle1.37471300
40MP0005220_abnormal_exocrine_pancreas1.37311152
41MP0005187_abnormal_penis_morphology1.36219448
42MP0004197_abnormal_fetal_growth/weight/1.35715622
43MP0003121_genomic_imprinting1.30399762
44MP0003195_calcinosis1.29041216
45MP0001286_abnormal_eye_development1.28750438
46MP0002138_abnormal_hepatobiliary_system1.28212604
47MP0004957_abnormal_blastocyst_morpholog1.27446981
48MP0004264_abnormal_extraembryonic_tissu1.26686030
49MP0004808_abnormal_hematopoietic_stem1.23862020
50MP0003755_abnormal_palate_morphology1.21427920
51MP0003136_yellow_coat_color1.21368685
52MP0002233_abnormal_nose_morphology1.20143521
53MP0003786_premature_aging1.19720271
54MP0005409_darkened_coat_color1.19131285
55MP0002928_abnormal_bile_duct1.16190049
56MP0003385_abnormal_body_wall1.12109728
57MP0002075_abnormal_coat/hair_pigmentati1.12004679
58MP0002006_tumorigenesis1.11032811
59MP0003567_abnormal_fetal_cardiomyocyte1.10563430
60MP0002751_abnormal_autonomic_nervous1.10054848
61MP0009780_abnormal_chondrocyte_physiolo1.09099852
62MP0003283_abnormal_digestive_organ1.09004578
63MP0000432_abnormal_head_morphology1.07199146
64MP0002085_abnormal_embryonic_tissue1.07164481
65MP0010234_abnormal_vibrissa_follicle1.06462565
66MP0002111_abnormal_tail_morphology1.06330707
67MP0006292_abnormal_olfactory_placode1.06057595
68MP0000350_abnormal_cell_proliferation1.05778602
69MP0002102_abnormal_ear_morphology1.05492060
70MP0002009_preneoplasia1.03005826
71MP0001324_abnormal_eye_pigmentation1.02851993
72MP0003122_maternal_imprinting1.01639148
73MP0002086_abnormal_extraembryonic_tissu0.99885767
74MP0000377_abnormal_hair_follicle0.99520233
75MP0004885_abnormal_endolymph0.99066499
76MP0000462_abnormal_digestive_system0.97071557
77MP0001944_abnormal_pancreas_morphology0.94175621
78MP0001186_pigmentation_phenotype0.93505420
79MP0005174_abnormal_tail_pigmentation0.93318647
80MP0001929_abnormal_gametogenesis0.93299426
81MP0008995_early_reproductive_senescence0.91774840
82MP0002234_abnormal_pharynx_morphology0.90343722
83MP0005551_abnormal_eye_electrophysiolog0.90334776
84MP0000631_abnormal_neuroendocrine_gland0.89813537
85MP0002160_abnormal_reproductive_system0.89463672
86MP0003119_abnormal_digestive_system0.86662396
87MP0003936_abnormal_reproductive_system0.86432362
88MP0000428_abnormal_craniofacial_morphol0.85706979
89MP0000778_abnormal_nervous_system0.85278854
90MP0003950_abnormal_plasma_membrane0.85040469
91MP0008004_abnormal_stomach_pH0.84889675
92MP0004381_abnormal_hair_follicle0.84640438
93MP0000003_abnormal_adipose_tissue0.84533934
94MP0002697_abnormal_eye_size0.83517157
95MP0001177_atelectasis0.83382709
96MP0006072_abnormal_retinal_apoptosis0.83111211
97MP0002177_abnormal_outer_ear0.80925754
98MP0009672_abnormal_birth_weight0.80232309
99MP0002166_altered_tumor_susceptibility0.80230897
100MP0005171_absent_coat_pigmentation0.79637164

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.57118968
2Renal cortical cysts (HP:0000803)4.22140449
3Volvulus (HP:0002580)3.81910487
4Curly hair (HP:0002212)3.75879481
5Abnormality of chromosome stability (HP:0003220)3.55310384
6Thyroid carcinoma (HP:0002890)3.33846278
7Chromsome breakage (HP:0040012)3.14242622
8Abnormality of the renal cortex (HP:0011035)3.10741544
9Aqueductal stenosis (HP:0002410)2.95021653
10Aplasia/Hypoplasia of the uvula (HP:0010293)2.87334259
11Abnormality of the ischium (HP:0003174)2.83548095
12Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83462010
13Rhabdomyosarcoma (HP:0002859)2.82858511
14Overlapping toe (HP:0001845)2.62256568
15Generalized hypopigmentation of hair (HP:0011358)2.57012046
16Hypoplastic ischia (HP:0003175)2.44374288
17Abnormality of the pancreatic islet cells (HP:0006476)2.42471991
18Abnormality of endocrine pancreas physiology (HP:0012093)2.42471991
19Acute myeloid leukemia (HP:0004808)2.41842180
20Meckel diverticulum (HP:0002245)2.41354822
21Aplasia/Hypoplasia of the fovea (HP:0008060)2.39030476
22Hypoplasia of the fovea (HP:0007750)2.39030476
23Abnormal pancreas size (HP:0012094)2.37897149
24Abnormality of the preputium (HP:0100587)2.34684838
25Cystic hygroma (HP:0000476)2.30204043
26Abnormality of the ileum (HP:0001549)2.28795382
27Hypoplastic labia majora (HP:0000059)2.27242669
28Transitional cell carcinoma of the bladder (HP:0006740)2.26442821
29Intestinal atresia (HP:0011100)2.26248169
30Heterotopia (HP:0002282)2.17915546
31Chronic hepatic failure (HP:0100626)2.16421388
32Fair hair (HP:0002286)2.13370675
33Breast carcinoma (HP:0003002)2.13110115
34Embryonal renal neoplasm (HP:0011794)2.10755646
35Low anterior hairline (HP:0000294)2.10679339
36Prominent nose (HP:0000448)2.10197451
37Macroorchidism (HP:0000053)2.07525063
38Wide nose (HP:0000445)2.05854848
39Neoplasm of the oral cavity (HP:0100649)2.05680219
40Gaze-evoked nystagmus (HP:0000640)2.04551611
41Bladder neoplasm (HP:0009725)2.03766366
42Bladder carcinoma (HP:0002862)2.03766366
43Short chin (HP:0000331)2.03030217
44Colon cancer (HP:0003003)2.00799065
45Nephroblastoma (Wilms tumor) (HP:0002667)1.98756240
46Abnormality of the labia majora (HP:0012881)1.98482531
47Abnormality of the fovea (HP:0000493)1.97671559
48Abnormal biliary tract morphology (HP:0012440)1.96615329
49Median cleft lip (HP:0000161)1.96463650
50Abnormal auditory evoked potentials (HP:0006958)1.93462436
51Microglossia (HP:0000171)1.92228474
52Ectopic kidney (HP:0000086)1.91000274
53Abnormality of the duodenum (HP:0002246)1.88942658
54Stomach cancer (HP:0012126)1.88538318
55Tubulointerstitial nephritis (HP:0001970)1.88437038
56Clubbing of toes (HP:0100760)1.88389775
57Protruding tongue (HP:0010808)1.87917059
58Aplasia/Hypoplasia of the tibia (HP:0005772)1.86199870
59Pancreatic islet-cell hyperplasia (HP:0004510)1.84773557
60Abnormality of the carotid arteries (HP:0005344)1.84434577
61Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83315161
62Malignant gastrointestinal tract tumors (HP:0006749)1.82887610
63Gastrointestinal carcinoma (HP:0002672)1.82887610
64Duodenal stenosis (HP:0100867)1.81654348
65Small intestinal stenosis (HP:0012848)1.81654348
66Neoplasm of the thyroid gland (HP:0100031)1.81361101
67Blue irides (HP:0000635)1.80226396
68Scrotal hypoplasia (HP:0000046)1.79461026
69Sloping forehead (HP:0000340)1.79357706
70Neoplasm of the small intestine (HP:0100833)1.78655184
71Villous atrophy (HP:0011473)1.78304000
72Abnormality of small intestinal villus morphology (HP:0011472)1.78304000
73Bifid tongue (HP:0010297)1.77450355
74Leiomyosarcoma (HP:0100243)1.76068421
75Uterine leiomyosarcoma (HP:0002891)1.76068421
76Pulmonic stenosis (HP:0001642)1.75483843
77Cafe-au-lait spot (HP:0000957)1.75188763
78Hyperventilation (HP:0002883)1.74825420
79Deep philtrum (HP:0002002)1.73610067
80Abnormality of the renal medulla (HP:0100957)1.72872990
81Glioma (HP:0009733)1.72489155
82Abnormality of incisor morphology (HP:0011063)1.72073050
83Testicular neoplasm (HP:0010788)1.69473067
84Patchy hypopigmentation of hair (HP:0011365)1.68757322
85Myelodysplasia (HP:0002863)1.68355764
86Severe visual impairment (HP:0001141)1.68285976
87Neoplasm of the adrenal cortex (HP:0100641)1.67895152
88Astrocytoma (HP:0009592)1.67504507
89Abnormality of the astrocytes (HP:0100707)1.67504507
90Hypoplastic iliac wings (HP:0002866)1.67374720
91Midline defect of the nose (HP:0004122)1.66627219
92Astigmatism (HP:0000483)1.66023618
93Arteriovenous malformation (HP:0100026)1.65457807
94Neoplasm of striated muscle (HP:0009728)1.65319260
95Pancreatic fibrosis (HP:0100732)1.64648428
96Abnormal lung lobation (HP:0002101)1.64205877
97Ependymoma (HP:0002888)1.62284960
98Large earlobe (HP:0009748)1.61380589
99Exotropia (HP:0000577)1.61047547
100Short tibia (HP:0005736)1.60805460

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD43.26482973
2FRK3.26253910
3CASK3.06305266
4PNCK2.96920281
5WEE12.80184702
6EIF2AK32.74307409
7STK38L2.59010715
8BRSK22.49689551
9EIF2AK12.48542163
10STK242.41852567
11STK392.23450556
12ACVR1B2.02912689
13NLK2.01275624
14YES11.97658729
15LATS11.94046270
16WNK31.85285509
17MKNK21.83987440
18STK31.83595515
19MAP3K101.83459411
20ERBB31.79117025
21NEK11.75411118
22MAP3K21.67498106
23TSSK61.67146691
24ZAK1.60958310
25TRIM281.56031278
26NEK91.51192248
27BMPR1B1.44861674
28FGFR21.42709335
29IRAK11.39903104
30AKT31.37602540
31TNIK1.34643636
32MST41.32328716
33TTK1.32111336
34PAK31.22075027
35FGFR11.21497868
36MAP3K41.12195925
37FGFR31.08517631
38PLK41.03914481
39BCR1.00600311
40WNK41.00024549
41CAMK1G0.99165329
42FER0.98557987
43INSRR0.97529036
44NUAK10.95858202
45NEK20.95422701
46SGK20.90909533
47MKNK10.89146181
48SGK30.84664516
49CHEK20.83273146
50PLK30.81899814
51MELK0.81883665
52CDK40.81827677
53ERBB40.79915490
54NTRK30.79694969
55WNK10.78684761
56TRPM70.78256024
57FLT30.74253468
58CSNK1G10.74015260
59SCYL20.72145263
60ATM0.69481292
61SRPK10.68686269
62PASK0.66218644
63KSR10.66086713
64CDK60.65753469
65NEK60.64987684
66MAP4K20.64586366
67EIF2AK20.64513111
68TLK10.59116774
69IRAK20.58627755
70PLK10.55957773
71JAK10.55890851
72CHUK0.54854071
73RPS6KB10.54695339
74OXSR10.53397779
75ATR0.52990793
76MET0.52245862
77PIK3CA0.47547905
78TEC0.45712333
79CHEK10.45356539
80TAF10.42854813
81MAPK100.41762895
82PBK0.38512784
83PKN20.36971314
84RPS6KB20.34129500
85CDK10.33114836
86DYRK1A0.32013643
87PLK20.31927097
88PRKAA20.31053157
89PRKCH0.29167782
90BRSK10.28666679
91CDC70.28602174
92MAPK130.26807272
93CSNK1E0.26562421
94CLK10.25409529
95PINK10.25369700
96PRKCE0.25206950
97CDK30.25096159
98CSNK1D0.24258768
99EGFR0.23929725
100CDK20.23865064

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.25769575
2Protein export_Homo sapiens_hsa030603.19160185
3Fanconi anemia pathway_Homo sapiens_hsa034603.15698141
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.58671652
5RNA degradation_Homo sapiens_hsa030182.35861972
6Homologous recombination_Homo sapiens_hsa034402.34030772
7Circadian rhythm_Homo sapiens_hsa047102.28111927
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26635791
9Dorso-ventral axis formation_Homo sapiens_hsa043202.10069872
10Basal transcription factors_Homo sapiens_hsa030222.06174126
11mRNA surveillance pathway_Homo sapiens_hsa030151.97558170
12Cell cycle_Homo sapiens_hsa041101.89586096
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88599736
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87301504
15p53 signaling pathway_Homo sapiens_hsa041151.85818248
16RNA transport_Homo sapiens_hsa030131.85463539
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.81175668
18Propanoate metabolism_Homo sapiens_hsa006401.65167184
19Butanoate metabolism_Homo sapiens_hsa006501.65039994
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59584636
21Hedgehog signaling pathway_Homo sapiens_hsa043401.56913621
22TGF-beta signaling pathway_Homo sapiens_hsa043501.49640843
23Prostate cancer_Homo sapiens_hsa052151.45018645
24FoxO signaling pathway_Homo sapiens_hsa040681.44931777
25Lysine degradation_Homo sapiens_hsa003101.44910646
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42419935
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39765480
28Inositol phosphate metabolism_Homo sapiens_hsa005621.38153066
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27448751
30Prolactin signaling pathway_Homo sapiens_hsa049171.27011187
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24241389
32Mismatch repair_Homo sapiens_hsa034301.21854633
33MicroRNAs in cancer_Homo sapiens_hsa052061.19853465
34Basal cell carcinoma_Homo sapiens_hsa052171.18354608
35One carbon pool by folate_Homo sapiens_hsa006701.15391524
36Nucleotide excision repair_Homo sapiens_hsa034201.15299360
37Selenocompound metabolism_Homo sapiens_hsa004501.14750452
38Hippo signaling pathway_Homo sapiens_hsa043901.12818482
39Caffeine metabolism_Homo sapiens_hsa002321.11639347
40Colorectal cancer_Homo sapiens_hsa052101.11597611
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04277761
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00962633
43Adherens junction_Homo sapiens_hsa045200.99062546
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97940662
45Renal cell carcinoma_Homo sapiens_hsa052110.97347976
46Oocyte meiosis_Homo sapiens_hsa041140.96265667
47ErbB signaling pathway_Homo sapiens_hsa040120.95604771
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95310751
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93415509
50Small cell lung cancer_Homo sapiens_hsa052220.92991060
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90937142
52Endometrial cancer_Homo sapiens_hsa052130.90642950
53Chronic myeloid leukemia_Homo sapiens_hsa052200.90602688
54Wnt signaling pathway_Homo sapiens_hsa043100.87957956
55Thyroid cancer_Homo sapiens_hsa052160.85137208
56Glioma_Homo sapiens_hsa052140.83490807
57Sphingolipid metabolism_Homo sapiens_hsa006000.83254086
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.82847050
59Steroid biosynthesis_Homo sapiens_hsa001000.77631664
60mTOR signaling pathway_Homo sapiens_hsa041500.77126810
61Type II diabetes mellitus_Homo sapiens_hsa049300.75857087
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74034871
63Melanoma_Homo sapiens_hsa052180.69274525
64Insulin resistance_Homo sapiens_hsa049310.69246982
65Spliceosome_Homo sapiens_hsa030400.68924256
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66510569
67Ether lipid metabolism_Homo sapiens_hsa005650.66402390
68Base excision repair_Homo sapiens_hsa034100.66321160
69Nitrogen metabolism_Homo sapiens_hsa009100.65970659
70Pancreatic cancer_Homo sapiens_hsa052120.63267680
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63265915
72Measles_Homo sapiens_hsa051620.62527986
73Non-small cell lung cancer_Homo sapiens_hsa052230.61344218
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57605485
75Regulation of autophagy_Homo sapiens_hsa041400.56914813
76Hepatitis B_Homo sapiens_hsa051610.54950156
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54878954
78Viral carcinogenesis_Homo sapiens_hsa052030.53673984
79Tight junction_Homo sapiens_hsa045300.52483824
80Olfactory transduction_Homo sapiens_hsa047400.52292413
81Insulin signaling pathway_Homo sapiens_hsa049100.49990006
82Melanogenesis_Homo sapiens_hsa049160.49853356
83Alcoholism_Homo sapiens_hsa050340.49668535
84Taste transduction_Homo sapiens_hsa047420.46902145
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46348757
86Pathways in cancer_Homo sapiens_hsa052000.44325994
87Proteoglycans in cancer_Homo sapiens_hsa052050.43628240
88Choline metabolism in cancer_Homo sapiens_hsa052310.40183795
89Herpes simplex infection_Homo sapiens_hsa051680.39509060
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.38550839
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38421791
92Retinol metabolism_Homo sapiens_hsa008300.37391681
93Hepatitis C_Homo sapiens_hsa051600.37207194
94ABC transporters_Homo sapiens_hsa020100.36692504
95Thyroid hormone synthesis_Homo sapiens_hsa049180.29794175
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29743645
97AMPK signaling pathway_Homo sapiens_hsa041520.29689971
98Glucagon signaling pathway_Homo sapiens_hsa049220.27886974
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27636427
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26554609

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