ZNF121

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of DNA-dependent DNA replication (GO:2000104)4.44738419
2DNA double-strand break processing (GO:0000729)4.28727418
3chromatin remodeling at centromere (GO:0031055)4.20636932
4negative regulation of translation, ncRNA-mediated (GO:0040033)4.18058250
5regulation of translation, ncRNA-mediated (GO:0045974)4.18058250
6negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.18058250
7DNA replication checkpoint (GO:0000076)3.97732538
8CENP-A containing nucleosome assembly (GO:0034080)3.92684645
9regulation of mitotic spindle checkpoint (GO:1903504)3.89954558
10regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.89954558
11regulation of DNA endoreduplication (GO:0032875)3.85781339
12regulation of centriole replication (GO:0046599)3.82558176
13replication fork processing (GO:0031297)3.80252164
14regulation of gene silencing by RNA (GO:0060966)3.76343485
15regulation of posttranscriptional gene silencing (GO:0060147)3.76343485
16regulation of gene silencing by miRNA (GO:0060964)3.76343485
17somatic hypermutation of immunoglobulin genes (GO:0016446)3.73608206
18somatic diversification of immune receptors via somatic mutation (GO:0002566)3.73608206
19histone exchange (GO:0043486)3.66687254
20protein prenylation (GO:0018342)3.55843940
21prenylation (GO:0097354)3.55843940
22regulation of nuclear cell cycle DNA replication (GO:0033262)3.48196197
23RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.30614454
24DNA replication-dependent nucleosome organization (GO:0034723)3.24139249
25DNA replication-dependent nucleosome assembly (GO:0006335)3.24139249
26regulation of helicase activity (GO:0051095)3.22305066
27isotype switching (GO:0045190)3.22084946
28somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.22084946
29somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.22084946
30maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.18121997
31double-strand break repair via homologous recombination (GO:0000724)3.17556490
32recombinational repair (GO:0000725)3.16717975
33double-strand break repair via nonhomologous end joining (GO:0006303)3.15750532
34non-recombinational repair (GO:0000726)3.15750532
35synapsis (GO:0007129)3.11688287
36negative regulation of DNA recombination (GO:0045910)3.11262752
37mitotic sister chromatid cohesion (GO:0007064)3.10501578
38somatic recombination of immunoglobulin gene segments (GO:0016447)3.07186463
39spindle checkpoint (GO:0031577)3.07169081
40DNA replication-independent nucleosome organization (GO:0034724)3.03330098
41DNA replication-independent nucleosome assembly (GO:0006336)3.03330098
42negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02399610
43negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02399610
44negative regulation of mitotic sister chromatid separation (GO:2000816)3.02399610
45negative regulation of sister chromatid segregation (GO:0033046)3.02399610
46negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02399610
47response to X-ray (GO:0010165)3.01818218
48mitotic spindle checkpoint (GO:0071174)2.99348969
49regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.98822489
50regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98822489
51IMP biosynthetic process (GO:0006188)2.98061288
52nuclear pore organization (GO:0006999)2.97720976
53negative regulation of chromosome segregation (GO:0051985)2.96915712
54nuclear pore complex assembly (GO:0051292)2.96914879
55kinetochore organization (GO:0051383)2.95701215
56somatic diversification of immunoglobulins (GO:0016445)2.93966273
57regulation of mesoderm development (GO:2000380)2.93024619
58regulation of sister chromatid segregation (GO:0033045)2.92776895
59regulation of mitotic sister chromatid separation (GO:0010965)2.92776895
60regulation of mitotic sister chromatid segregation (GO:0033047)2.92776895
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90390355
62regulation of centrosome cycle (GO:0046605)2.89137788
63telomere maintenance via telomerase (GO:0007004)2.87838115
64mitotic metaphase plate congression (GO:0007080)2.87106043
65protein localization to kinetochore (GO:0034501)2.86795990
66regulation of centrosome duplication (GO:0010824)2.85332941
67DNA catabolic process, exonucleolytic (GO:0000738)2.83893735
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81789698
69water-soluble vitamin biosynthetic process (GO:0042364)2.81245258
70kinetochore assembly (GO:0051382)2.79899129
71metaphase plate congression (GO:0051310)2.78028252
72pre-miRNA processing (GO:0031054)2.77204919
73maturation of 5.8S rRNA (GO:0000460)2.73358711
74mitotic G2/M transition checkpoint (GO:0044818)2.70448954
75nucleobase biosynthetic process (GO:0046112)2.70390839
76purine nucleobase biosynthetic process (GO:0009113)2.70051293
77DNA strand elongation involved in DNA replication (GO:0006271)2.67774137
78somatic cell DNA recombination (GO:0016444)2.67036835
79somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.67036835
80mitotic spindle assembly checkpoint (GO:0007094)2.65168589
81pseudouridine synthesis (GO:0001522)2.63936882
82ncRNA catabolic process (GO:0034661)2.63698031
83spindle assembly checkpoint (GO:0071173)2.62373618
84L-fucose catabolic process (GO:0042355)2.61342508
85fucose catabolic process (GO:0019317)2.61342508
86L-fucose metabolic process (GO:0042354)2.61342508
87somatic diversification of immune receptors (GO:0002200)2.60834722
88mitochondrial RNA metabolic process (GO:0000959)2.60705983
89regulation of chromosome segregation (GO:0051983)2.58475479
90attachment of spindle microtubules to kinetochore (GO:0008608)2.58252675
91positive regulation of chromosome segregation (GO:0051984)2.58251044
92IMP metabolic process (GO:0046040)2.57922250
93mitotic recombination (GO:0006312)2.57565434
94protein K6-linked ubiquitination (GO:0085020)2.55984652
95dorsal/ventral axis specification (GO:0009950)2.55978917
96centriole replication (GO:0007099)2.54513972
97reciprocal meiotic recombination (GO:0007131)2.54496128
98reciprocal DNA recombination (GO:0035825)2.54496128
99behavioral response to nicotine (GO:0035095)2.54273111
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.53009465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.62757207
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.38289069
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33931452
4VDR_22108803_ChIP-Seq_LS180_Human3.07010846
5ZNF274_21170338_ChIP-Seq_K562_Hela3.01643146
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91572573
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77789346
8EWS_26573619_Chip-Seq_HEK293_Human2.60225802
9FUS_26573619_Chip-Seq_HEK293_Human2.48874639
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.34878299
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34279449
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27132314
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.25747323
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.23406734
15TAF15_26573619_Chip-Seq_HEK293_Human2.21470691
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21145689
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.16626945
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.15256214
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.13354271
20ELK1_19687146_ChIP-ChIP_HELA_Human2.12305096
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10175496
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07682315
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02318241
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02057051
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00135978
26IGF1R_20145208_ChIP-Seq_DFB_Human1.99606683
27GBX2_23144817_ChIP-Seq_PC3_Human1.97441772
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97276711
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97274151
30P300_19829295_ChIP-Seq_ESCs_Human1.96027479
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79843795
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68614446
33MYC_18940864_ChIP-ChIP_HL60_Human1.64828048
34IRF1_19129219_ChIP-ChIP_H3396_Human1.61648111
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58019723
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55102015
37VDR_23849224_ChIP-Seq_CD4+_Human1.53236025
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49613455
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47269841
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46591947
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.46563772
42NANOG_16153702_ChIP-ChIP_HESCs_Human1.45583576
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.40758867
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.32631612
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.30489618
46* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29306110
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28550684
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.27553173
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26974625
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26822515
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26582342
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26507643
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.25172837
54FOXP3_21729870_ChIP-Seq_TREG_Human1.23628008
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22314226
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21542918
57ER_23166858_ChIP-Seq_MCF-7_Human1.20557995
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19759048
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19455722
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19455722
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18907557
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.18340399
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16611946
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16563431
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14791494
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14042523
67BCAT_22108803_ChIP-Seq_LS180_Human1.13820603
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13445922
69SMAD4_21799915_ChIP-Seq_A2780_Human1.13377288
70AR_21909140_ChIP-Seq_LNCAP_Human1.13021985
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12663566
72* STAT3_23295773_ChIP-Seq_U87_Human1.12260470
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.12092737
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10935277
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08250109
76CBP_20019798_ChIP-Seq_JUKART_Human1.08250109
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07938905
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.07204526
79TCF4_22108803_ChIP-Seq_LS180_Human1.05808967
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05011108
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03238100
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02922126
83* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02464287
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01954952
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01481835
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01481835
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01481835
88TCF4_23295773_ChIP-Seq_U87_Human1.00615244
89JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00210774
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00095216
91* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96835997
92SOX2_19829295_ChIP-Seq_ESCs_Human0.96047291
93NANOG_19829295_ChIP-Seq_ESCs_Human0.96047291
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94801214
95RNF2_27304074_Chip-Seq_NSC_Mouse0.93986899
96AR_25329375_ChIP-Seq_VCAP_Human0.93889898
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93886546
98TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89680427
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89375532
100* RUNX2_22187159_ChIP-Seq_PCA_Human0.88995005

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.71498250
2MP0008057_abnormal_DNA_replication3.49778471
3MP0010094_abnormal_chromosome_stability3.39066274
4MP0008058_abnormal_DNA_repair3.38420751
5MP0003693_abnormal_embryo_hatching3.05261326
6MP0003890_abnormal_embryonic-extraembry2.92220780
7MP0006292_abnormal_olfactory_placode2.71408838
8MP0003111_abnormal_nucleus_morphology2.30409926
9MP0003718_maternal_effect2.27023508
10MP0003937_abnormal_limbs/digits/tail_de2.15770589
11MP0004957_abnormal_blastocyst_morpholog2.14122064
12MP0001293_anophthalmia2.11707116
13MP0002102_abnormal_ear_morphology2.06398227
14MP0003077_abnormal_cell_cycle2.00676983
15MP0002938_white_spotting1.98207058
16MP0003941_abnormal_skin_development1.93479474
17MP0003136_yellow_coat_color1.91896011
18MP0008007_abnormal_cellular_replicative1.89652656
19MP0000569_abnormal_digit_pigmentation1.83336717
20MP0008932_abnormal_embryonic_tissue1.74979480
21MP0006072_abnormal_retinal_apoptosis1.71483939
22MP0003119_abnormal_digestive_system1.68159464
23MP0003787_abnormal_imprinting1.63105426
24MP0001188_hyperpigmentation1.61631886
25MP0004133_heterotaxia1.57177202
26MP0009697_abnormal_copulation1.56924930
27MP0003567_abnormal_fetal_cardiomyocyte1.54348683
28MP0001485_abnormal_pinna_reflex1.51640977
29MP0003121_genomic_imprinting1.50125989
30MP0003195_calcinosis1.49846774
31MP0002751_abnormal_autonomic_nervous1.48674168
32MP0000631_abnormal_neuroendocrine_gland1.38037952
33MP0001286_abnormal_eye_development1.37179016
34MP0003646_muscle_fatigue1.37090646
35MP0002736_abnormal_nociception_after1.36307667
36MP0000383_abnormal_hair_follicle1.31265588
37MP0005253_abnormal_eye_physiology1.28316914
38MP0002160_abnormal_reproductive_system1.23696465
39MP0003786_premature_aging1.22145737
40MP0005551_abnormal_eye_electrophysiolog1.21237801
41MP0002254_reproductive_system_inflammat1.19610728
42MP0002084_abnormal_developmental_patter1.13194363
43MP0000049_abnormal_middle_ear1.13085824
44MP0001929_abnormal_gametogenesis1.11601293
45MP0002210_abnormal_sex_determination1.10311597
46MP0004197_abnormal_fetal_growth/weight/1.09771062
47MP0005367_renal/urinary_system_phenotyp1.07962327
48MP0000516_abnormal_urinary_system1.07962327
49MP0001529_abnormal_vocalization1.06370084
50MP0008789_abnormal_olfactory_epithelium1.05332893
51MP0000647_abnormal_sebaceous_gland1.04142149
52MP0000372_irregular_coat_pigmentation1.02062709
53MP0002697_abnormal_eye_size1.01578478
54MP0002233_abnormal_nose_morphology1.01269250
55MP0005389_reproductive_system_phenotype1.00974490
56MP0002085_abnormal_embryonic_tissue0.99873898
57MP0001968_abnormal_touch/_nociception0.99774205
58MP0003123_paternal_imprinting0.98963685
59MP0000427_abnormal_hair_cycle0.98141050
60MP0009672_abnormal_birth_weight0.97681574
61MP0010307_abnormal_tumor_latency0.96982888
62MP0002837_dystrophic_cardiac_calcinosis0.96843730
63MP0001145_abnormal_male_reproductive0.96685039
64MP0000653_abnormal_sex_gland0.96546466
65MP0001177_atelectasis0.95393457
66MP0000566_synostosis0.94928809
67MP0009703_decreased_birth_body0.93530595
68MP0008995_early_reproductive_senescence0.91089862
69MP0004147_increased_porphyrin_level0.90551683
70MP0005391_vision/eye_phenotype0.90296006
71MP0001672_abnormal_embryogenesis/_devel0.90232337
72MP0005380_embryogenesis_phenotype0.90232337
73MP0001697_abnormal_embryo_size0.88619294
74MP0004215_abnormal_myocardial_fiber0.88555230
75MP0002638_abnormal_pupillary_reflex0.88325379
76MP0003755_abnormal_palate_morphology0.87988237
77MP0002111_abnormal_tail_morphology0.86896533
78MP0008872_abnormal_physiological_respon0.85676988
79MP0000350_abnormal_cell_proliferation0.85535011
80MP0006276_abnormal_autonomic_nervous0.82709897
81MP0005395_other_phenotype0.82410051
82MP0003861_abnormal_nervous_system0.82269317
83MP0010678_abnormal_skin_adnexa0.81467942
84MP0003698_abnormal_male_reproductive0.81393176
85MP0006035_abnormal_mitochondrial_morpho0.80717934
86MP0001919_abnormal_reproductive_system0.80161306
87MP0003880_abnormal_central_pattern0.78927307
88MP0005187_abnormal_penis_morphology0.78629793
89MP0010352_gastrointestinal_tract_polyps0.78196636
90MP0001486_abnormal_startle_reflex0.78133377
91MP0001119_abnormal_female_reproductive0.75245532
92MP0001984_abnormal_olfaction0.75241275
93MP0009046_muscle_twitch0.74267734
94MP0002088_abnormal_embryonic_growth/wei0.73746529
95MP0005174_abnormal_tail_pigmentation0.73375389
96MP0003984_embryonic_growth_retardation0.72617742
97MP0000428_abnormal_craniofacial_morphol0.71725547
98MP0005499_abnormal_olfactory_system0.71027559
99MP0005394_taste/olfaction_phenotype0.71027559
100MP0001730_embryonic_growth_arrest0.70921709

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.70548657
2Chromsome breakage (HP:0040012)3.57381324
3Abnormality of the labia minora (HP:0012880)3.44824832
4Colon cancer (HP:0003003)3.30797720
5Birth length less than 3rd percentile (HP:0003561)3.18621921
6Abnormality of chromosome stability (HP:0003220)3.17202707
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.13641348
8Pancreatic cysts (HP:0001737)2.97982132
9Meckel diverticulum (HP:0002245)2.97819804
10Abnormality of the ileum (HP:0001549)2.89478790
11Pancreatic fibrosis (HP:0100732)2.62975158
12Abnormality of the renal collecting system (HP:0004742)2.56627034
13Abnormality of the preputium (HP:0100587)2.54549701
14Abnormality of midbrain morphology (HP:0002418)2.52519037
15Molar tooth sign on MRI (HP:0002419)2.52519037
16True hermaphroditism (HP:0010459)2.50503178
17Nephronophthisis (HP:0000090)2.45390924
18Duplicated collecting system (HP:0000081)2.44381586
19Ectopic kidney (HP:0000086)2.44074753
20Ependymoma (HP:0002888)2.42856756
21Volvulus (HP:0002580)2.42464262
22Stenosis of the external auditory canal (HP:0000402)2.37388613
23Duodenal stenosis (HP:0100867)2.32896712
24Small intestinal stenosis (HP:0012848)2.32896712
25Clubbing of toes (HP:0100760)2.31417759
26Intestinal atresia (HP:0011100)2.30794121
27Glioma (HP:0009733)2.30747838
28Hyperalaninemia (HP:0003348)2.30446025
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30446025
30Abnormality of alanine metabolism (HP:0010916)2.30446025
31Abnormal lung lobation (HP:0002101)2.25967851
32Embryonal renal neoplasm (HP:0011794)2.25312694
33Septo-optic dysplasia (HP:0100842)2.25266662
34Sloping forehead (HP:0000340)2.23627086
35Nephroblastoma (Wilms tumor) (HP:0002667)2.23018637
36Abnormality of the duodenum (HP:0002246)2.22490066
37Abolished electroretinogram (ERG) (HP:0000550)2.19261848
38Small hand (HP:0200055)2.19066605
39Rhabdomyosarcoma (HP:0002859)2.16237088
40Absent radius (HP:0003974)2.11006964
41Abnormality of the renal medulla (HP:0100957)2.07628916
42Progressive inability to walk (HP:0002505)2.07373694
43Chronic hepatic failure (HP:0100626)2.06716666
44Abnormality of the pons (HP:0007361)2.05630605
45Pendular nystagmus (HP:0012043)2.03719052
46Aplasia involving forearm bones (HP:0009822)2.03306891
47Absent forearm bone (HP:0003953)2.03306891
48Abnormality of serum amino acid levels (HP:0003112)2.02905561
49Broad-based gait (HP:0002136)2.02879591
50Triphalangeal thumb (HP:0001199)2.01994352
51Hypoplasia of the pons (HP:0012110)2.00824582
52Methylmalonic acidemia (HP:0002912)2.00210130
53Neoplasm of the adrenal cortex (HP:0100641)1.97146538
54Abnormality of the carotid arteries (HP:0005344)1.95658879
55Medial flaring of the eyebrow (HP:0010747)1.95517813
56Patellar aplasia (HP:0006443)1.94568134
57Astrocytoma (HP:0009592)1.93998620
58Abnormality of the astrocytes (HP:0100707)1.93998620
59Medulloblastoma (HP:0002885)1.92818205
60Aplasia/Hypoplasia of the tibia (HP:0005772)1.92351959
61Aplasia/Hypoplasia of the sternum (HP:0006714)1.90347641
62Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90137186
63Esophageal atresia (HP:0002032)1.87843108
64Protruding tongue (HP:0010808)1.84800403
65Gastrointestinal atresia (HP:0002589)1.83911352
66Bilateral microphthalmos (HP:0007633)1.82936673
67Absent thumb (HP:0009777)1.81673295
68Supernumerary spleens (HP:0009799)1.80844987
69Oligodactyly (hands) (HP:0001180)1.80729344
70Aplasia/Hypoplasia of the patella (HP:0006498)1.80597219
71Genital tract atresia (HP:0001827)1.79705672
72Congenital stationary night blindness (HP:0007642)1.78610160
73Gaze-evoked nystagmus (HP:0000640)1.78454112
74Vaginal atresia (HP:0000148)1.78266410
75Optic nerve hypoplasia (HP:0000609)1.77027765
76Hyperglycinemia (HP:0002154)1.76827689
77Dandy-Walker malformation (HP:0001305)1.76538155
78Anencephaly (HP:0002323)1.74536493
79Preaxial hand polydactyly (HP:0001177)1.74021214
80Inability to walk (HP:0002540)1.73519673
81Sclerocornea (HP:0000647)1.73344723
82Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71458801
83Abnormality of the renal cortex (HP:0011035)1.70369162
84Hypoplastic pelvis (HP:0008839)1.66769584
85Congenital primary aphakia (HP:0007707)1.65610564
86Pancreatic islet-cell hyperplasia (HP:0004510)1.65041182
87Hypoplastic female external genitalia (HP:0012815)1.64767357
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.64129718
89Myelodysplasia (HP:0002863)1.63864372
90Labial hypoplasia (HP:0000066)1.63653851
91Bile duct proliferation (HP:0001408)1.61170285
92Abnormal biliary tract physiology (HP:0012439)1.61170285
93Neoplasm of striated muscle (HP:0009728)1.60346684
94Chorioretinal atrophy (HP:0000533)1.60298391
95Abnormality of homocysteine metabolism (HP:0010919)1.60049851
96Homocystinuria (HP:0002156)1.60049851
97Horseshoe kidney (HP:0000085)1.60029427
98Gait imbalance (HP:0002141)1.59539399
99Tubular atrophy (HP:0000092)1.59230224
100Abnormality of glycine metabolism (HP:0010895)1.59027013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK24.88040112
2FRK3.47499600
3MKNK13.31415831
4ZAK3.06766610
5TNIK2.69543772
6ACVR1B2.59476299
7TSSK62.58420172
8BUB12.54903662
9WNK32.53496487
10CDC72.50779638
11BRSK22.49474736
12BMPR1B2.48468284
13NUAK12.45270255
14TRIM282.17763037
15TTK2.14856372
16WEE12.07005842
17PLK42.06467125
18PLK31.99996269
19SRPK11.97413169
20MST41.71749963
21EIF2AK31.69526616
22TAF11.59228233
23VRK11.53803793
24PNCK1.51962734
25GRK11.46714501
26MAP4K21.36396481
27TLK11.35826985
28PLK11.33508588
29CASK1.30212485
30NLK1.27714031
31MAP3K41.24620263
32PBK1.21015904
33ADRBK21.15838274
34CHEK21.11479693
35BRD41.07812605
36ERBB41.05979481
37INSRR1.03500115
38TGFBR11.03162296
39ATR1.00373475
40NEK11.00104928
41STK38L0.99790008
42OXSR10.99177729
43PLK20.94900838
44STK390.93453784
45STK30.93075400
46ERBB30.92727791
47VRK20.91538623
48STK160.90876367
49CSNK1G10.88969759
50AKT30.87264298
51DYRK20.79085433
52LATS10.78304191
53ATM0.74677891
54MAPK130.74626494
55EIF2AK20.74005518
56FGFR20.71097918
57PASK0.70366502
58BRSK10.67566575
59WNK40.67064203
60BCR0.65766176
61NEK20.64219411
62DYRK30.60134376
63EIF2AK10.59792114
64CSNK1G20.58996241
65NME10.57753111
66FGFR10.57080349
67AURKB0.56924647
68CHEK10.52068805
69CDK30.51386729
70PRKCG0.51200676
71CSNK1A1L0.51105489
72SGK20.50868130
73FLT30.49608652
74CSNK1G30.49200069
75DYRK1A0.48551896
76TEC0.48252464
77MAP2K70.46705438
78PRKCE0.46559989
79TIE10.46200436
80MELK0.45500738
81PAK30.42473581
82PINK10.42392692
83CSNK1E0.38744172
84CAMK1G0.38107311
85CDK10.37358567
86ALK0.34961750
87PRKDC0.34593570
88RPS6KA50.33596598
89CSNK2A10.31413201
90RPS6KA40.30402141
91CSNK1A10.30326618
92CDK20.29894097
93ADRBK10.29860772
94PDK20.27404439
95OBSCN0.26631262
96STK240.26138088
97CSNK1D0.25221676
98CSNK2A20.24235875
99YES10.23066752
100CAMK1D0.21199330

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.28086383
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25212551
3Mismatch repair_Homo sapiens_hsa034303.16853505
4Homologous recombination_Homo sapiens_hsa034403.12256014
5RNA polymerase_Homo sapiens_hsa030202.78545561
6Fanconi anemia pathway_Homo sapiens_hsa034602.75377749
7DNA replication_Homo sapiens_hsa030302.64011030
8One carbon pool by folate_Homo sapiens_hsa006702.30233873
9Basal transcription factors_Homo sapiens_hsa030222.28827720
10RNA degradation_Homo sapiens_hsa030182.27903799
11RNA transport_Homo sapiens_hsa030132.21720739
12Selenocompound metabolism_Homo sapiens_hsa004502.18269217
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14977093
14Proteasome_Homo sapiens_hsa030502.13084156
15Protein export_Homo sapiens_hsa030602.03797615
16Cell cycle_Homo sapiens_hsa041101.90326347
17Propanoate metabolism_Homo sapiens_hsa006401.86178823
18Nucleotide excision repair_Homo sapiens_hsa034201.84645906
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.79930881
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77316160
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66417964
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63487981
23Spliceosome_Homo sapiens_hsa030401.53447953
24Base excision repair_Homo sapiens_hsa034101.46062363
25Steroid biosynthesis_Homo sapiens_hsa001001.45972247
26Phototransduction_Homo sapiens_hsa047441.36797305
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32609769
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29657555
29Butanoate metabolism_Homo sapiens_hsa006501.29376681
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28648881
31Nitrogen metabolism_Homo sapiens_hsa009101.23695343
32Purine metabolism_Homo sapiens_hsa002301.19975427
33Pyrimidine metabolism_Homo sapiens_hsa002401.19165001
34p53 signaling pathway_Homo sapiens_hsa041151.19126384
35Nicotine addiction_Homo sapiens_hsa050331.14554174
36mRNA surveillance pathway_Homo sapiens_hsa030151.13835798
37Taste transduction_Homo sapiens_hsa047421.13787790
38Vitamin B6 metabolism_Homo sapiens_hsa007501.07069282
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05957494
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03654594
41Vitamin digestion and absorption_Homo sapiens_hsa049771.03093880
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01263095
43Tryptophan metabolism_Homo sapiens_hsa003800.98677710
44Linoleic acid metabolism_Homo sapiens_hsa005910.97240442
45Systemic lupus erythematosus_Homo sapiens_hsa053220.94127117
46Lysine degradation_Homo sapiens_hsa003100.93730439
47Ether lipid metabolism_Homo sapiens_hsa005650.92695497
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92230179
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91961926
50TGF-beta signaling pathway_Homo sapiens_hsa043500.90183248
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.89537448
52Oxidative phosphorylation_Homo sapiens_hsa001900.87566343
53Caffeine metabolism_Homo sapiens_hsa002320.86588693
54Pyruvate metabolism_Homo sapiens_hsa006200.84253912
55Oocyte meiosis_Homo sapiens_hsa041140.83848514
56Parkinsons disease_Homo sapiens_hsa050120.83115588
57Huntingtons disease_Homo sapiens_hsa050160.82452304
58Retinol metabolism_Homo sapiens_hsa008300.80742160
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80681496
60Basal cell carcinoma_Homo sapiens_hsa052170.79180909
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78707783
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78696434
63Ribosome_Homo sapiens_hsa030100.75844603
64Hippo signaling pathway_Homo sapiens_hsa043900.72046117
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70764288
66Hedgehog signaling pathway_Homo sapiens_hsa043400.70228504
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69864421
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67903171
69Alcoholism_Homo sapiens_hsa050340.66478738
70Olfactory transduction_Homo sapiens_hsa047400.62896239
71beta-Alanine metabolism_Homo sapiens_hsa004100.62186497
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61271269
73Peroxisome_Homo sapiens_hsa041460.61169811
74Wnt signaling pathway_Homo sapiens_hsa043100.55946145
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53280458
76Metabolic pathways_Homo sapiens_hsa011000.52477691
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.47547326
78Fatty acid elongation_Homo sapiens_hsa000620.46343296
79Serotonergic synapse_Homo sapiens_hsa047260.45440764
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45091469
81Chemical carcinogenesis_Homo sapiens_hsa052040.43640547
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43284840
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42556149
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.41294176
85Fatty acid degradation_Homo sapiens_hsa000710.37824387
86Glycerolipid metabolism_Homo sapiens_hsa005610.36806812
87Circadian rhythm_Homo sapiens_hsa047100.36409675
88Alzheimers disease_Homo sapiens_hsa050100.35492383
89Glutathione metabolism_Homo sapiens_hsa004800.33278903
90Glutamatergic synapse_Homo sapiens_hsa047240.30836301
91Sulfur metabolism_Homo sapiens_hsa009200.30062017
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29458077
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28019871
94MicroRNAs in cancer_Homo sapiens_hsa052060.26131476
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25935435
96Fatty acid metabolism_Homo sapiens_hsa012120.25750456
97Fat digestion and absorption_Homo sapiens_hsa049750.23561921
98Morphine addiction_Homo sapiens_hsa050320.23475217
99Tight junction_Homo sapiens_hsa045300.22083091
100Melanoma_Homo sapiens_hsa052180.21885825

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