ZNF124

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.89600987
2neural tube formation (GO:0001841)4.46481551
3replication fork processing (GO:0031297)4.26213570
4behavioral response to nicotine (GO:0035095)3.98744770
5tryptophan catabolic process (GO:0006569)3.62566255
6indole-containing compound catabolic process (GO:0042436)3.62566255
7indolalkylamine catabolic process (GO:0046218)3.62566255
8negative regulation of DNA-dependent DNA replication (GO:2000104)3.51352338
9indolalkylamine metabolic process (GO:0006586)3.44420442
10negative regulation of translation, ncRNA-mediated (GO:0040033)3.42450826
11regulation of translation, ncRNA-mediated (GO:0045974)3.42450826
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.42450826
13kynurenine metabolic process (GO:0070189)3.39314899
14maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.35415614
15tryptophan metabolic process (GO:0006568)3.29023806
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28311179
17prenylation (GO:0097354)3.23820105
18protein prenylation (GO:0018342)3.23820105
19regulation of nuclear cell cycle DNA replication (GO:0033262)3.21960224
20recombinational repair (GO:0000725)3.17819634
21double-strand break repair via homologous recombination (GO:0000724)3.17612679
22L-fucose catabolic process (GO:0042355)3.12845911
23fucose catabolic process (GO:0019317)3.12845911
24L-fucose metabolic process (GO:0042354)3.12845911
25limb bud formation (GO:0060174)3.08942927
26centriole replication (GO:0007099)3.06972879
27resolution of meiotic recombination intermediates (GO:0000712)3.03682924
28detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02884234
29pyrimidine nucleobase catabolic process (GO:0006208)3.01080491
30regulation of DNA endoreduplication (GO:0032875)2.99509721
31regulation of mitotic spindle checkpoint (GO:1903504)2.99316122
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99316122
33intraciliary transport (GO:0042073)2.98856743
34somite development (GO:0061053)2.97455804
35RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.95239200
36synapsis (GO:0007129)2.92147919
37reciprocal meiotic recombination (GO:0007131)2.91067877
38reciprocal DNA recombination (GO:0035825)2.91067877
39regulation of centriole replication (GO:0046599)2.89789337
40protein K11-linked deubiquitination (GO:0035871)2.88722174
41translesion synthesis (GO:0019985)2.86443342
42microtubule anchoring (GO:0034453)2.85980194
43postreplication repair (GO:0006301)2.85960768
44sympathetic nervous system development (GO:0048485)2.85541567
45response to pheromone (GO:0019236)2.85061096
46photoreceptor cell maintenance (GO:0045494)2.82224107
47kidney morphogenesis (GO:0060993)2.82107732
48platelet dense granule organization (GO:0060155)2.78917128
49negative regulation of transcription regulatory region DNA binding (GO:2000678)2.78810709
50regulation of sarcomere organization (GO:0060297)2.77355150
51monoubiquitinated protein deubiquitination (GO:0035520)2.76567760
52somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74667657
53somatic hypermutation of immunoglobulin genes (GO:0016446)2.74667657
54epithelial cilium movement (GO:0003351)2.72469166
55protein polyglutamylation (GO:0018095)2.70374493
56cilium morphogenesis (GO:0060271)2.69899851
57behavioral response to ethanol (GO:0048149)2.69486395
58chromatin remodeling at centromere (GO:0031055)2.68624213
59tachykinin receptor signaling pathway (GO:0007217)2.66955505
60regulation of centrosome duplication (GO:0010824)2.65783985
61reflex (GO:0060004)2.64879416
62negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64490253
63detection of light stimulus involved in visual perception (GO:0050908)2.63542016
64detection of light stimulus involved in sensory perception (GO:0050962)2.63542016
65regulation of hippo signaling (GO:0035330)2.61086290
66DNA replication-dependent nucleosome assembly (GO:0006335)2.59689749
67DNA replication-dependent nucleosome organization (GO:0034723)2.59689749
68dorsal/ventral axis specification (GO:0009950)2.57773060
69cellular response to sterol (GO:0036315)2.56009824
70retinal cone cell development (GO:0046549)2.55217454
71cilium organization (GO:0044782)2.54933450
72CENP-A containing nucleosome assembly (GO:0034080)2.53253070
73cilium or flagellum-dependent cell motility (GO:0001539)2.52774258
74central nervous system neuron axonogenesis (GO:0021955)2.52342017
75establishment of protein localization to Golgi (GO:0072600)2.51545766
76presynaptic membrane assembly (GO:0097105)2.51488732
77cilium assembly (GO:0042384)2.49489903
78regulation of telomere maintenance (GO:0032204)2.49342846
79regulation of centrosome cycle (GO:0046605)2.48533543
80double-strand break repair via nonhomologous end joining (GO:0006303)2.48282274
81non-recombinational repair (GO:0000726)2.48282274
82regulation of pigment cell differentiation (GO:0050932)2.47441569
83regulation of meiosis I (GO:0060631)2.46710207
84indole-containing compound metabolic process (GO:0042430)2.45630608
85signal peptide processing (GO:0006465)2.44417416
86positive regulation of developmental pigmentation (GO:0048087)2.43646074
87nucleobase catabolic process (GO:0046113)2.42470105
88embryonic epithelial tube formation (GO:0001838)2.41234318
89DNA catabolic process, exonucleolytic (GO:0000738)2.40288466
90microtubule depolymerization (GO:0007019)2.39659473
91negative regulation of DNA recombination (GO:0045910)2.39178653
92microtubule organizing center organization (GO:0031023)2.39018424
93positive regulation of oligodendrocyte differentiation (GO:0048714)2.38443216
94atrial cardiac muscle cell action potential (GO:0086014)2.37695619
95histone exchange (GO:0043486)2.37031500
96central nervous system projection neuron axonogenesis (GO:0021952)2.35802288
97olfactory bulb development (GO:0021772)2.35477182
98sulfation (GO:0051923)2.33111562
99cornea development in camera-type eye (GO:0061303)2.32972444
100piRNA metabolic process (GO:0034587)2.32901667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.23538066
2ZNF274_21170338_ChIP-Seq_K562_Hela3.21037854
3IGF1R_20145208_ChIP-Seq_DFB_Human3.09965575
4GBX2_23144817_ChIP-Seq_PC3_Human2.92941388
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.92853350
6VDR_22108803_ChIP-Seq_LS180_Human2.75474783
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.75459364
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.73560686
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67704107
10FUS_26573619_Chip-Seq_HEK293_Human2.62279468
11TAF15_26573619_Chip-Seq_HEK293_Human2.51838825
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49301731
13EWS_26573619_Chip-Seq_HEK293_Human2.46136397
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40233294
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38532940
16P300_19829295_ChIP-Seq_ESCs_Human2.29667772
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.21519152
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17799400
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11201053
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03762402
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88674719
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87965329
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79983307
24ER_23166858_ChIP-Seq_MCF-7_Human1.71863433
25SMAD4_21799915_ChIP-Seq_A2780_Human1.70447377
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.67454910
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66531169
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66343407
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66225931
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65577317
31SMAD3_21741376_ChIP-Seq_EPCs_Human1.59945169
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59655480
33* STAT3_23295773_ChIP-Seq_U87_Human1.57947318
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55113894
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54955677
36CBP_20019798_ChIP-Seq_JUKART_Human1.54955677
37EZH2_22144423_ChIP-Seq_EOC_Human1.54674092
38BCAT_22108803_ChIP-Seq_LS180_Human1.52853717
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52806675
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51771617
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50284845
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49838720
43ELK1_19687146_ChIP-ChIP_HELA_Human1.49123978
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48849267
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48256553
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.46649831
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46145142
48IRF1_19129219_ChIP-ChIP_H3396_Human1.45529736
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45327695
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43222254
51* TCF4_23295773_ChIP-Seq_U87_Human1.42900313
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42460196
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41177650
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40955600
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40350510
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40350510
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.39941360
58AR_25329375_ChIP-Seq_VCAP_Human1.37825567
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36921784
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.36791331
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.33301164
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.31323929
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29256143
64TCF4_22108803_ChIP-Seq_LS180_Human1.28454748
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26085342
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25883151
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25656994
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.25186530
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23545775
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.23180700
71RUNX2_22187159_ChIP-Seq_PCA_Human1.22771127
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.20806094
73NANOG_19829295_ChIP-Seq_ESCs_Human1.20029899
74SOX2_19829295_ChIP-Seq_ESCs_Human1.20029899
75RNF2_27304074_Chip-Seq_NSC_Mouse1.18504796
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.16835265
77MYC_18940864_ChIP-ChIP_HL60_Human1.16378880
78TP53_22573176_ChIP-Seq_HFKS_Human1.15983384
79P53_22387025_ChIP-Seq_ESCs_Mouse1.14502214
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.13817301
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.10607594
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.10296835
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10077924
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09688266
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06156870
86TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05103846
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.05049025
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04052747
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.03673869
90GATA1_22025678_ChIP-Seq_K562_Human1.03604446
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02753430
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.02672591
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02458492
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02268352
95CDX2_22108803_ChIP-Seq_LS180_Human1.01552656
96P300_18555785_Chip-Seq_ESCs_Mouse1.01177925
97E2F7_22180533_ChIP-Seq_HELA_Human1.00542790
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00315799
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.00043517
100FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99024336

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.34835292
2MP0000569_abnormal_digit_pigmentation3.32794681
3MP0002102_abnormal_ear_morphology3.15254522
4MP0003890_abnormal_embryonic-extraembry2.69871943
5MP0008877_abnormal_DNA_methylation2.44310052
6MP0006292_abnormal_olfactory_placode2.41619861
7MP0006072_abnormal_retinal_apoptosis2.32962285
8MP0002638_abnormal_pupillary_reflex2.24714121
9MP0005551_abnormal_eye_electrophysiolog2.19860213
10MP0008058_abnormal_DNA_repair2.12174673
11MP0005253_abnormal_eye_physiology2.02252339
12MP0002234_abnormal_pharynx_morphology1.98770480
13MP0003195_calcinosis1.98020029
14MP0002938_white_spotting1.94662835
15MP0003787_abnormal_imprinting1.87618614
16MP0010094_abnormal_chromosome_stability1.83693345
17MP0003136_yellow_coat_color1.82997947
18MP0003880_abnormal_central_pattern1.82956678
19MP0002736_abnormal_nociception_after1.76160617
20MP0000372_irregular_coat_pigmentation1.72487952
21MP0002751_abnormal_autonomic_nervous1.69618979
22MP0003937_abnormal_limbs/digits/tail_de1.61351519
23MP0000631_abnormal_neuroendocrine_gland1.61105868
24MP0003718_maternal_effect1.60475830
25MP0001968_abnormal_touch/_nociception1.59841594
26MP0004133_heterotaxia1.57582174
27MP0003567_abnormal_fetal_cardiomyocyte1.56985530
28MP0009046_muscle_twitch1.54674318
29MP0005174_abnormal_tail_pigmentation1.53404362
30MP0003646_muscle_fatigue1.53340355
31MP0010386_abnormal_urinary_bladder1.49659872
32MP0001293_anophthalmia1.49602525
33MP0000427_abnormal_hair_cycle1.48887171
34MP0000778_abnormal_nervous_system1.48759777
35MP0005646_abnormal_pituitary_gland1.43831024
36MP0003121_genomic_imprinting1.43048668
37MP0004215_abnormal_myocardial_fiber1.40650496
38MP0001986_abnormal_taste_sensitivity1.39255685
39MP0001486_abnormal_startle_reflex1.37037593
40MP0000383_abnormal_hair_follicle1.36741571
41MP0006276_abnormal_autonomic_nervous1.36335394
42MP0005645_abnormal_hypothalamus_physiol1.35760576
43MP0002735_abnormal_chemical_nociception1.35208958
44MP0001485_abnormal_pinna_reflex1.24716926
45MP0003119_abnormal_digestive_system1.21769225
46MP0002837_dystrophic_cardiac_calcinosis1.21496125
47MP0005391_vision/eye_phenotype1.19564067
48MP0008789_abnormal_olfactory_epithelium1.17819663
49MP0005195_abnormal_posterior_eye1.17648635
50MP0001984_abnormal_olfaction1.16075875
51MP0002233_abnormal_nose_morphology1.14337791
52MP0001529_abnormal_vocalization1.14313619
53MP0008872_abnormal_physiological_respon1.14296950
54MP0005367_renal/urinary_system_phenotyp1.13334090
55MP0000516_abnormal_urinary_system1.13334090
56MP0004147_increased_porphyrin_level1.10631537
57MP0001324_abnormal_eye_pigmentation1.08565838
58MP0002272_abnormal_nervous_system1.07766530
59MP0009697_abnormal_copulation1.05687694
60MP0001286_abnormal_eye_development1.05260356
61MP0002653_abnormal_ependyma_morphology1.04328009
62MP0005386_behavior/neurological_phenoty1.04057855
63MP0004924_abnormal_behavior1.04057855
64MP0004043_abnormal_pH_regulation1.02758882
65MP0000647_abnormal_sebaceous_gland1.02286920
66MP0004142_abnormal_muscle_tone1.01501013
67MP0004145_abnormal_muscle_electrophysio1.01200641
68MP0002095_abnormal_skin_pigmentation0.99416783
69MP0002752_abnormal_somatic_nervous0.97934012
70MP0008995_early_reproductive_senescence0.97754635
71MP0005499_abnormal_olfactory_system0.97544111
72MP0005394_taste/olfaction_phenotype0.97544111
73MP0002184_abnormal_innervation0.96712570
74MP0009745_abnormal_behavioral_response0.96619784
75MP0005084_abnormal_gallbladder_morpholo0.94803443
76MP0010678_abnormal_skin_adnexa0.94116923
77MP0003693_abnormal_embryo_hatching0.91809635
78MP0001929_abnormal_gametogenesis0.90340248
79MP0001764_abnormal_homeostasis0.86733526
80MP0003137_abnormal_impulse_conducting0.86560959
81MP0002210_abnormal_sex_determination0.85559998
82MP0002557_abnormal_social/conspecific_i0.84700366
83MP0003698_abnormal_male_reproductive0.84437030
84MP0005187_abnormal_penis_morphology0.84251051
85MP0002160_abnormal_reproductive_system0.84024124
86MP0002067_abnormal_sensory_capabilities0.83697434
87MP0002090_abnormal_vision0.82349445
88MP0005085_abnormal_gallbladder_physiolo0.80863610
89MP0000653_abnormal_sex_gland0.79260948
90MP0003122_maternal_imprinting0.78834197
91MP0003755_abnormal_palate_morphology0.77968486
92MP0005171_absent_coat_pigmentation0.77815695
93MP0000049_abnormal_middle_ear0.77628925
94MP0002734_abnormal_mechanical_nocicepti0.77196501
95MP0005167_abnormal_blood-brain_barrier0.75462997
96MP0001177_atelectasis0.74205844
97MP0000955_abnormal_spinal_cord0.73438123
98MP0002572_abnormal_emotion/affect_behav0.73364862
99MP0001145_abnormal_male_reproductive0.72617516
100MP0001501_abnormal_sleep_pattern0.71710998

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.11054751
2Pancreatic fibrosis (HP:0100732)3.61617248
3True hermaphroditism (HP:0010459)3.57092555
4Hyperventilation (HP:0002883)3.45507925
5Abnormality of midbrain morphology (HP:0002418)3.37859637
6Molar tooth sign on MRI (HP:0002419)3.37859637
7Nephronophthisis (HP:0000090)3.30652003
8Chronic hepatic failure (HP:0100626)3.13274437
9Intestinal atresia (HP:0011100)2.98614409
10Abnormality of the renal cortex (HP:0011035)2.96050434
11Volvulus (HP:0002580)2.94514852
12Abnormality of the renal medulla (HP:0100957)2.94368602
13Colon cancer (HP:0003003)2.85809456
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.75863693
15Congenital stationary night blindness (HP:0007642)2.72162896
16Gaze-evoked nystagmus (HP:0000640)2.64627053
17Abnormality of the labia minora (HP:0012880)2.57104163
18Abnormality of chromosome stability (HP:0003220)2.53046780
19Medial flaring of the eyebrow (HP:0010747)2.51722092
20Aplasia/Hypoplasia of the tibia (HP:0005772)2.48590998
21Drooling (HP:0002307)2.44533297
22Renal cortical cysts (HP:0000803)2.42163208
23Abnormality of the ileum (HP:0001549)2.40961608
24Protruding tongue (HP:0010808)2.38099391
25Attenuation of retinal blood vessels (HP:0007843)2.37433671
26Abolished electroretinogram (ERG) (HP:0000550)2.36615711
27Meckel diverticulum (HP:0002245)2.36562974
28Abnormal biliary tract physiology (HP:0012439)2.33105666
29Bile duct proliferation (HP:0001408)2.33105666
30Cystic liver disease (HP:0006706)2.30104691
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.26127370
32Tubular atrophy (HP:0000092)2.25478241
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24511125
34Abnormality of alanine metabolism (HP:0010916)2.20014029
35Hyperalaninemia (HP:0003348)2.20014029
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20014029
37Excessive salivation (HP:0003781)2.16712462
38Broad-based gait (HP:0002136)2.16560960
39Sloping forehead (HP:0000340)2.12388291
40Pendular nystagmus (HP:0012043)2.12076205
41Sclerocornea (HP:0000647)2.11813931
42Progressive inability to walk (HP:0002505)2.11338515
43Genital tract atresia (HP:0001827)2.10899250
44Cerebellar dysplasia (HP:0007033)2.09603057
45Chromsome breakage (HP:0040012)2.09504596
46Anencephaly (HP:0002323)2.08578759
47Supernumerary spleens (HP:0009799)2.06117738
48Congenital hepatic fibrosis (HP:0002612)2.06074031
49Lissencephaly (HP:0001339)2.05664036
50Inability to walk (HP:0002540)2.05393575
51Vaginal atresia (HP:0000148)2.05270096
52Small hand (HP:0200055)2.03506024
53Congenital primary aphakia (HP:0007707)2.02490094
54Gait imbalance (HP:0002141)2.02252096
55Genetic anticipation (HP:0003743)2.02246516
56Thyroiditis (HP:0100646)2.01006869
57Fair hair (HP:0002286)2.00634544
58Absent speech (HP:0001344)1.99098700
59Progressive cerebellar ataxia (HP:0002073)1.98849860
60Stomach cancer (HP:0012126)1.98085110
61Bifid tongue (HP:0010297)1.97355101
62Optic nerve hypoplasia (HP:0000609)1.96973025
63Type II lissencephaly (HP:0007260)1.96709725
64Glioma (HP:0009733)1.95961890
65Birth length less than 3rd percentile (HP:0003561)1.94244916
66Clubbing of toes (HP:0100760)1.92987013
67Abnormality of the preputium (HP:0100587)1.92935299
68Ectopic kidney (HP:0000086)1.91669963
69Narrow forehead (HP:0000341)1.90876040
70Nephrogenic diabetes insipidus (HP:0009806)1.89636529
71Dandy-Walker malformation (HP:0001305)1.89526656
72Abnormality of macular pigmentation (HP:0008002)1.88903451
73Postaxial foot polydactyly (HP:0001830)1.86415838
74Chorioretinal atrophy (HP:0000533)1.86147333
75Preaxial hand polydactyly (HP:0001177)1.84992121
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83802248
77Male pseudohermaphroditism (HP:0000037)1.83178117
78Polydipsia (HP:0001959)1.81795318
79Abnormal drinking behavior (HP:0030082)1.81795318
80Abnormality of the duodenum (HP:0002246)1.81173408
81Patellar aplasia (HP:0006443)1.80739306
82Cupped ear (HP:0000378)1.80257005
83Furrowed tongue (HP:0000221)1.77239801
84Abnormality of the astrocytes (HP:0100707)1.75956346
85Astrocytoma (HP:0009592)1.75956346
86Tubulointerstitial abnormality (HP:0001969)1.75696854
87Astigmatism (HP:0000483)1.75290289
88Small intestinal stenosis (HP:0012848)1.74120199
89Duodenal stenosis (HP:0100867)1.74120199
90Short tibia (HP:0005736)1.73912654
91Tubulointerstitial nephritis (HP:0001970)1.73846992
92Gastrointestinal atresia (HP:0002589)1.73589242
93Oligohydramnios (HP:0001562)1.73202642
94Hypothermia (HP:0002045)1.72843874
95Oligodactyly (hands) (HP:0001180)1.72524846
96Postaxial hand polydactyly (HP:0001162)1.71828376
97Bony spicule pigmentary retinopathy (HP:0007737)1.71116134
98Oculomotor apraxia (HP:0000657)1.70651581
99Thyroid-stimulating hormone excess (HP:0002925)1.68930809
100Disproportionate short-trunk short stature (HP:0003521)1.67282032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.12030546
2ZAK3.36898641
3ACVR1B3.08686110
4WNK33.08264865
5BMPR1B3.07881489
6CASK2.62293968
7MAP3K42.44855461
8MAP4K22.19917312
9NUAK12.16642998
10TNIK2.12360732
11MKNK22.02105594
12MAPK131.92957767
13TRIM281.91036946
14TLK11.90771451
15ADRBK21.72310426
16GRK11.66341944
17PLK41.59466506
18SRPK11.56878901
19BRSK21.53817029
20ERBB31.51390264
21MKNK11.48067139
22MAP2K71.45603344
23EIF2AK31.42932777
24STK38L1.35861305
25PINK11.33208642
26INSRR1.30806007
27STK391.29599424
28BCR1.24597782
29TGFBR11.24199065
30EPHA41.24068232
31WEE11.22916696
32PNCK1.22016287
33AKT31.19698104
34VRK11.13870604
35OXSR11.09907762
36PLK31.07180513
37PLK21.02098060
38TAOK31.01347574
39CSNK1G10.98540555
40TIE10.97058601
41BRD40.96244448
42CSNK1G20.95911426
43CDC70.93930918
44STK30.92358766
45MST40.89026012
46NEK10.88391461
47MARK10.87764861
48CSNK1A1L0.87562842
49CCNB10.86357145
50TSSK60.85071737
51PAK30.83833733
52WNK40.83200068
53CSNK1G30.82749845
54OBSCN0.77771008
55PBK0.77770606
56PRKCE0.73742476
57LATS10.71810540
58CHEK20.70785582
59MUSK0.70427448
60TEC0.69733083
61DYRK30.69135617
62DYRK20.69109209
63PLK10.69093952
64ADRBK10.65647871
65PRKCG0.64213232
66FLT30.61727163
67ATR0.61699475
68ATM0.60476895
69NLK0.59784358
70FGFR20.59386903
71TTK0.59099466
72MAP2K40.57863105
73SGK20.57275823
74CAMKK20.55861251
75PIK3CA0.54860984
76PIK3CG0.51765076
77PKN10.51049599
78FER0.48862380
79NEK20.48290920
80PDK20.47924799
81RPS6KA50.47076943
82BUB10.45843036
83CSNK1D0.41265863
84NTRK30.36670339
85DAPK20.35927477
86CAMK2A0.34009427
87PRKACB0.33981649
88ERBB20.32805202
89CSNK1A10.32265501
90EIF2AK20.31530712
91MINK10.31376945
92CAMK1G0.31280001
93CAMK40.31076629
94FGFR10.31047661
95PRKAA10.31015225
96CDK30.30920635
97BCKDK0.30594609
98STK240.28024720
99TAF10.26535627
100DYRK1A0.25777534

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.17418127
2Fanconi anemia pathway_Homo sapiens_hsa034603.01764771
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.79005198
4Homologous recombination_Homo sapiens_hsa034402.56561091
5Propanoate metabolism_Homo sapiens_hsa006402.39909294
6Phototransduction_Homo sapiens_hsa047442.37990915
7Basal transcription factors_Homo sapiens_hsa030222.27143449
8Butanoate metabolism_Homo sapiens_hsa006502.25725455
9Protein export_Homo sapiens_hsa030602.22616698
10Nicotine addiction_Homo sapiens_hsa050332.10989239
11Selenocompound metabolism_Homo sapiens_hsa004502.08673313
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90247020
13Nitrogen metabolism_Homo sapiens_hsa009101.83405327
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79749617
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78931700
16RNA polymerase_Homo sapiens_hsa030201.77853844
17RNA degradation_Homo sapiens_hsa030181.76971406
18Systemic lupus erythematosus_Homo sapiens_hsa053221.74143489
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72494694
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71041253
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70442731
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69741875
23Taste transduction_Homo sapiens_hsa047421.64342068
24Tryptophan metabolism_Homo sapiens_hsa003801.58707338
25Mismatch repair_Homo sapiens_hsa034301.56645837
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55233879
27Linoleic acid metabolism_Homo sapiens_hsa005911.48066972
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42802454
29Steroid biosynthesis_Homo sapiens_hsa001001.40372728
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38661640
31Alcoholism_Homo sapiens_hsa050341.37528774
32Ether lipid metabolism_Homo sapiens_hsa005651.34568200
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.33732847
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29563607
35RNA transport_Homo sapiens_hsa030131.24570246
36Olfactory transduction_Homo sapiens_hsa047401.23289123
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13317687
38Caffeine metabolism_Homo sapiens_hsa002321.12956722
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08169547
40Nucleotide excision repair_Homo sapiens_hsa034201.08036551
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.07057525
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.05764747
43Peroxisome_Homo sapiens_hsa041461.02303720
44DNA replication_Homo sapiens_hsa030301.01625888
45Oxidative phosphorylation_Homo sapiens_hsa001901.01606621
46Cell cycle_Homo sapiens_hsa041101.01369288
47TGF-beta signaling pathway_Homo sapiens_hsa043500.98854233
48ABC transporters_Homo sapiens_hsa020100.97792612
49One carbon pool by folate_Homo sapiens_hsa006700.95908450
50Morphine addiction_Homo sapiens_hsa050320.92938693
51Proteasome_Homo sapiens_hsa030500.87168883
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86851409
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86215233
54Purine metabolism_Homo sapiens_hsa002300.85266934
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.84252900
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84074149
57Retinol metabolism_Homo sapiens_hsa008300.82712913
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79138899
59Parkinsons disease_Homo sapiens_hsa050120.77252511
60Glutamatergic synapse_Homo sapiens_hsa047240.77156591
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76822868
62Lysine degradation_Homo sapiens_hsa003100.76406332
63GABAergic synapse_Homo sapiens_hsa047270.74825705
64Huntingtons disease_Homo sapiens_hsa050160.74630719
65Regulation of autophagy_Homo sapiens_hsa041400.73491432
66Circadian entrainment_Homo sapiens_hsa047130.72330225
67Hedgehog signaling pathway_Homo sapiens_hsa043400.72052286
68p53 signaling pathway_Homo sapiens_hsa041150.70033434
69Chemical carcinogenesis_Homo sapiens_hsa052040.69694909
70Base excision repair_Homo sapiens_hsa034100.69554129
71Serotonergic synapse_Homo sapiens_hsa047260.68868145
72Glycerolipid metabolism_Homo sapiens_hsa005610.68245908
73Basal cell carcinoma_Homo sapiens_hsa052170.67856922
74beta-Alanine metabolism_Homo sapiens_hsa004100.63364615
75Hippo signaling pathway_Homo sapiens_hsa043900.61063976
76Fat digestion and absorption_Homo sapiens_hsa049750.59932767
77Sulfur metabolism_Homo sapiens_hsa009200.59811479
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57096992
79Sphingolipid metabolism_Homo sapiens_hsa006000.54007342
80Pyrimidine metabolism_Homo sapiens_hsa002400.53340093
81Metabolic pathways_Homo sapiens_hsa011000.52086071
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51567232
83Oocyte meiosis_Homo sapiens_hsa041140.50782096
84Circadian rhythm_Homo sapiens_hsa047100.50598422
85Dopaminergic synapse_Homo sapiens_hsa047280.50433980
86mRNA surveillance pathway_Homo sapiens_hsa030150.49169945
87Calcium signaling pathway_Homo sapiens_hsa040200.49005701
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45917590
89Fatty acid metabolism_Homo sapiens_hsa012120.45854829
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44586589
91Fatty acid degradation_Homo sapiens_hsa000710.42893911
92Salivary secretion_Homo sapiens_hsa049700.40614925
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38823507
94Insulin secretion_Homo sapiens_hsa049110.36456228
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35817964
96Long-term depression_Homo sapiens_hsa047300.35779705
97Ovarian steroidogenesis_Homo sapiens_hsa049130.35325513
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35320607
99Vitamin digestion and absorption_Homo sapiens_hsa049770.34725286
100Fatty acid elongation_Homo sapiens_hsa000620.33998798

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