ZNF131

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hippo signaling (GO:0035330)6.86102100
2regulation of gene silencing by RNA (GO:0060966)6.73530516
3regulation of posttranscriptional gene silencing (GO:0060147)6.73530516
4regulation of gene silencing by miRNA (GO:0060964)6.73530516
5cytoplasmic mRNA processing body assembly (GO:0033962)6.44083475
6adult feeding behavior (GO:0008343)5.69576037
7regulation of feeding behavior (GO:0060259)5.59517743
8behavioral response to nicotine (GO:0035095)4.06534444
9alanine transport (GO:0032328)3.61156628
10establishment of protein localization to mitochondrial membrane (GO:0090151)3.59752072
11gene silencing by RNA (GO:0031047)3.58342671
12regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.56274882
13regulation of mitotic spindle checkpoint (GO:1903504)3.56274882
14histone H2A monoubiquitination (GO:0035518)3.49348479
15neural tube formation (GO:0001841)3.43535542
16piRNA metabolic process (GO:0034587)3.39957345
17regulation of gene silencing (GO:0060968)3.39441248
18ubiquinone metabolic process (GO:0006743)3.36243122
19negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.30739042
20negative regulation of translation, ncRNA-mediated (GO:0040033)3.30739042
21regulation of translation, ncRNA-mediated (GO:0045974)3.30739042
22negative regulation of macrophage differentiation (GO:0045650)3.29485643
23centriole replication (GO:0007099)3.26858530
24male meiosis (GO:0007140)3.26613938
25urinary tract smooth muscle contraction (GO:0014848)3.22701896
26histone H3-K9 methylation (GO:0051567)3.11755656
27somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10805212
28somatic hypermutation of immunoglobulin genes (GO:0016446)3.10805212
29DNA double-strand break processing (GO:0000729)3.07900568
30ubiquinone biosynthetic process (GO:0006744)3.07523797
31protein polyglutamylation (GO:0018095)3.01781058
32pyrimidine dimer repair (GO:0006290)2.96700164
33synapsis (GO:0007129)2.95516907
34histone H2A ubiquitination (GO:0033522)2.93840405
35protein-cofactor linkage (GO:0018065)2.88553343
36mitochondrial RNA metabolic process (GO:0000959)2.88511956
37ribosomal large subunit biogenesis (GO:0042273)2.88418356
38recombinational repair (GO:0000725)2.85827025
39double-strand break repair via homologous recombination (GO:0000724)2.85117826
40viral transcription (GO:0019083)2.80709030
41positive regulation of mRNA processing (GO:0050685)2.80403609
42regulation of DNA endoreduplication (GO:0032875)2.79513758
43translational termination (GO:0006415)2.77802049
44replication fork processing (GO:0031297)2.77655407
45reciprocal meiotic recombination (GO:0007131)2.76864621
46reciprocal DNA recombination (GO:0035825)2.76864621
47sex differentiation (GO:0007548)2.76182625
48response to pheromone (GO:0019236)2.73489528
49male meiosis I (GO:0007141)2.70618171
50cAMP catabolic process (GO:0006198)2.69665377
51maturation of SSU-rRNA (GO:0030490)2.68446312
52positive regulation of histone H3-K4 methylation (GO:0051571)2.65432492
53histone H3-K9 modification (GO:0061647)2.64966313
54somite development (GO:0061053)2.64724226
55pyrimidine nucleobase catabolic process (GO:0006208)2.64704060
56negative regulation of DNA-dependent DNA replication (GO:2000104)2.61408889
57cellular protein complex localization (GO:0034629)2.56664118
58regulation of action potential (GO:0098900)2.56628383
59viral mRNA export from host cell nucleus (GO:0046784)2.56523342
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56019236
61epithelial cilium movement (GO:0003351)2.54668478
62eating behavior (GO:0042755)2.52067511
63DNA methylation involved in gamete generation (GO:0043046)2.51717806
64regulation of centriole replication (GO:0046599)2.49831853
65central nervous system projection neuron axonogenesis (GO:0021952)2.49166793
66CENP-A containing nucleosome assembly (GO:0034080)2.48105046
67tachykinin receptor signaling pathway (GO:0007217)2.47428056
68chromatin remodeling at centromere (GO:0031055)2.46443718
69centriole assembly (GO:0098534)2.45324293
70sister chromatid cohesion (GO:0007062)2.45209772
71meiotic cell cycle (GO:0051321)2.44637821
72protein K6-linked ubiquitination (GO:0085020)2.44410493
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.42318538
74positive regulation of mRNA 3-end processing (GO:0031442)2.41166851
75tryptophan metabolic process (GO:0006568)2.41125690
76tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.41098307
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.41098307
78positive regulation of mRNA metabolic process (GO:1903313)2.39209823
79cilium movement (GO:0003341)2.38475315
80water-soluble vitamin biosynthetic process (GO:0042364)2.36948296
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.36628058
82histone exchange (GO:0043486)2.36316626
83sympathetic nervous system development (GO:0048485)2.35393124
84translational elongation (GO:0006414)2.34828900
85regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.32724443
86sulfation (GO:0051923)2.32660657
87cotranslational protein targeting to membrane (GO:0006613)2.31859700
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.30476606
89DNA catabolic process, exonucleolytic (GO:0000738)2.30357617
90ribosomal small subunit assembly (GO:0000028)2.29381896
91forebrain neuron development (GO:0021884)2.28594411
92indolalkylamine metabolic process (GO:0006586)2.27898985
93positive regulation of action potential (GO:0045760)2.27862493
94mitotic sister chromatid cohesion (GO:0007064)2.27797657
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.27287845
96chaperone-mediated protein complex assembly (GO:0051131)2.26716671
97RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.26288521
98cyclic nucleotide catabolic process (GO:0009214)2.26200476
99protein targeting to ER (GO:0045047)2.25999232
100photoreceptor cell maintenance (GO:0045494)2.25934887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse8.61744020
2EZH2_22144423_ChIP-Seq_EOC_Human3.34368202
3ZNF274_21170338_ChIP-Seq_K562_Hela3.26561897
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.79697820
5FUS_26573619_Chip-Seq_HEK293_Human2.76268569
6VDR_22108803_ChIP-Seq_LS180_Human2.70221244
7IGF1R_20145208_ChIP-Seq_DFB_Human2.57345958
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57262254
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49372699
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45243155
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44188975
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26386031
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.26095238
14EWS_26573619_Chip-Seq_HEK293_Human2.22883332
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.22274979
16ELK1_19687146_ChIP-ChIP_HELA_Human2.15273438
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09353983
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05786746
19E2F7_22180533_ChIP-Seq_HELA_Human2.05434903
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.01664890
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97958053
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95573933
23GBX2_23144817_ChIP-Seq_PC3_Human1.90918012
24AR_21572438_ChIP-Seq_LNCaP_Human1.89317288
25* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85728392
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.84778014
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81164469
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80357318
29ER_23166858_ChIP-Seq_MCF-7_Human1.74828983
30P300_19829295_ChIP-Seq_ESCs_Human1.70249981
31* VDR_23849224_ChIP-Seq_CD4+_Human1.65985648
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59927091
33RNF2_27304074_Chip-Seq_NSC_Mouse1.59171576
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.58126603
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56647505
36TAF15_26573619_Chip-Seq_HEK293_Human1.43686215
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43551880
38MYC_18940864_ChIP-ChIP_HL60_Human1.43546809
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40850238
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40066373
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37207342
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35876100
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34142169
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31698844
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30454987
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30143603
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29982764
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29982764
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29569822
50TP53_22573176_ChIP-Seq_HFKS_Human1.29156981
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25404952
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24922304
53AR_25329375_ChIP-Seq_VCAP_Human1.24458642
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.21323233
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.19043960
56STAT3_23295773_ChIP-Seq_U87_Human1.17438660
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16561371
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.15614065
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14748207
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13906952
61CBP_20019798_ChIP-Seq_JUKART_Human1.13906952
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12567947
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12267628
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10929581
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10051602
66IRF1_19129219_ChIP-ChIP_H3396_Human1.08892135
67FOXP3_21729870_ChIP-Seq_TREG_Human1.08136323
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.07366130
69RUNX2_22187159_ChIP-Seq_PCA_Human1.06467032
70REST_21632747_ChIP-Seq_MESCs_Mouse1.05307187
71JUN_21703547_ChIP-Seq_K562_Human1.03426264
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.03102309
73TCF4_23295773_ChIP-Seq_U87_Human1.02993023
74LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00196711
75SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99447857
76PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98838603
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98573710
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98442294
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98308802
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96196011
81SMAD3_21741376_ChIP-Seq_EPCs_Human0.95875655
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95751394
83NFE2_27457419_Chip-Seq_LIVER_Mouse0.95418426
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94891198
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.94112497
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.92338247
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92338247
88JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.89247148
89NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88551191
90ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87558465
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87446392
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86786913
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86633250
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86416864
95PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86289414
96* E2F1_21310950_ChIP-Seq_MCF-7_Human0.86064170
97HTT_18923047_ChIP-ChIP_STHdh_Human0.84818427
98GATA1_26923725_Chip-Seq_HPCs_Mouse0.84722078
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84224287
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.84172308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.37506383
2MP0006292_abnormal_olfactory_placode3.28917566
3MP0008058_abnormal_DNA_repair3.02892884
4MP0001661_extended_life_span3.01686127
5MP0008877_abnormal_DNA_methylation2.99583711
6MP0008057_abnormal_DNA_replication2.75076220
7MP0001529_abnormal_vocalization2.49347753
8MP0000372_irregular_coat_pigmentation2.27446321
9MP0003693_abnormal_embryo_hatching2.26986368
10MP0005646_abnormal_pituitary_gland2.19402291
11MP0006072_abnormal_retinal_apoptosis2.12523357
12MP0003890_abnormal_embryonic-extraembry2.10528774
13MP0009379_abnormal_foot_pigmentation2.05752669
14MP0002735_abnormal_chemical_nociception2.02581060
15MP0001968_abnormal_touch/_nociception1.96007934
16MP0003880_abnormal_central_pattern1.95691935
17MP0010094_abnormal_chromosome_stability1.95308515
18MP0000383_abnormal_hair_follicle1.93130944
19MP0002277_abnormal_respiratory_mucosa1.91006878
20MP0000631_abnormal_neuroendocrine_gland1.82479472
21MP0004133_heterotaxia1.77424375
22MP0001293_anophthalmia1.75779127
23MP0002822_catalepsy1.73503127
24MP0005551_abnormal_eye_electrophysiolog1.73185483
25MP0009697_abnormal_copulation1.73126586
26MP0004142_abnormal_muscle_tone1.72997753
27MP0000427_abnormal_hair_cycle1.67896873
28MP0005171_absent_coat_pigmentation1.49845394
29MP0002736_abnormal_nociception_after1.49180230
30MP0002102_abnormal_ear_morphology1.46711488
31MP0005253_abnormal_eye_physiology1.45679248
32MP0003718_maternal_effect1.41812644
33MP0002160_abnormal_reproductive_system1.41197215
34MP0008789_abnormal_olfactory_epithelium1.39289834
35MP0000569_abnormal_digit_pigmentation1.38448526
36MP0002095_abnormal_skin_pigmentation1.35097771
37MP0002653_abnormal_ependyma_morphology1.33062233
38MP0002210_abnormal_sex_determination1.32566913
39MP0002234_abnormal_pharynx_morphology1.31504982
40MP0005645_abnormal_hypothalamus_physiol1.29309716
41MP0001929_abnormal_gametogenesis1.29226268
42MP0000516_abnormal_urinary_system1.26148652
43MP0005367_renal/urinary_system_phenotyp1.26148652
44MP0003787_abnormal_imprinting1.24616283
45MP0002638_abnormal_pupillary_reflex1.24503883
46MP0000778_abnormal_nervous_system1.24372352
47MP0006276_abnormal_autonomic_nervous1.23934210
48MP0001485_abnormal_pinna_reflex1.23634211
49MP0005389_reproductive_system_phenotype1.23266723
50MP0004742_abnormal_vestibular_system1.23154292
51MP0008995_early_reproductive_senescence1.23049533
52MP0003698_abnormal_male_reproductive1.13920140
53MP0003937_abnormal_limbs/digits/tail_de1.09749023
54MP0004885_abnormal_endolymph1.09607238
55MP0003959_abnormal_lean_body1.05959926
56MP0000653_abnormal_sex_gland1.05513161
57MP0009046_muscle_twitch1.03602845
58MP0002751_abnormal_autonomic_nervous1.03392576
59MP0001286_abnormal_eye_development1.02424416
60MP0002876_abnormal_thyroid_physiology1.02376257
61MP0001188_hyperpigmentation1.02133375
62MP0002067_abnormal_sensory_capabilities1.01096907
63MP0001324_abnormal_eye_pigmentation1.00368487
64MP0003077_abnormal_cell_cycle1.00070197
65MP0001145_abnormal_male_reproductive0.99069158
66MP0001919_abnormal_reproductive_system0.98907794
67MP0002272_abnormal_nervous_system0.98658096
68MP0005075_abnormal_melanosome_morpholog0.98573085
69MP0009745_abnormal_behavioral_response0.97908970
70MP0008932_abnormal_embryonic_tissue0.95033172
71MP0003121_genomic_imprinting0.93796721
72MP0005391_vision/eye_phenotype0.92500564
73MP0008007_abnormal_cellular_replicative0.92470141
74MP0005394_taste/olfaction_phenotype0.91023097
75MP0005499_abnormal_olfactory_system0.91023097
76MP0000647_abnormal_sebaceous_gland0.90735890
77MP0003567_abnormal_fetal_cardiomyocyte0.88636251
78MP0004147_increased_porphyrin_level0.87736425
79MP0003635_abnormal_synaptic_transmissio0.87677455
80MP0002938_white_spotting0.86496814
81MP0005195_abnormal_posterior_eye0.86466634
82MP0004957_abnormal_blastocyst_morpholog0.86056521
83MP0001486_abnormal_startle_reflex0.85783374
84MP0005386_behavior/neurological_phenoty0.85026489
85MP0004924_abnormal_behavior0.85026489
86MP0008872_abnormal_physiological_respon0.84188764
87MP0003786_premature_aging0.83058473
88MP0005187_abnormal_penis_morphology0.83042098
89MP0010678_abnormal_skin_adnexa0.82878512
90MP0001970_abnormal_pain_threshold0.80792480
91MP0002572_abnormal_emotion/affect_behav0.80719350
92MP0002752_abnormal_somatic_nervous0.76521345
93MP0002184_abnormal_innervation0.75629730
94MP0003943_abnormal_hepatobiliary_system0.75613113
95MP0003119_abnormal_digestive_system0.75517276
96MP0002233_abnormal_nose_morphology0.74377438
97MP0001764_abnormal_homeostasis0.74332006
98MP0002282_abnormal_trachea_morphology0.74066556
99MP0003861_abnormal_nervous_system0.72676475
100MP0001119_abnormal_female_reproductive0.72462575

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)3.96092751
2Molar tooth sign on MRI (HP:0002419)3.23794299
3Abnormality of midbrain morphology (HP:0002418)3.23794299
4Pancreatic cysts (HP:0001737)3.21225716
5Lissencephaly (HP:0001339)3.15141681
6Hyperventilation (HP:0002883)3.01478378
7Nephronophthisis (HP:0000090)2.98566069
8Pancreatic fibrosis (HP:0100732)2.96011513
9True hermaphroditism (HP:0010459)2.91913635
10Volvulus (HP:0002580)2.88180206
11Aplastic anemia (HP:0001915)2.79069433
12Cerebellar dysplasia (HP:0007033)2.67596383
13Abnormality of the renal medulla (HP:0100957)2.66737597
14Scotoma (HP:0000575)2.61690139
15Reticulocytopenia (HP:0001896)2.58239764
16Broad-based gait (HP:0002136)2.49372613
17Septo-optic dysplasia (HP:0100842)2.45365960
18Abnormality of DNA repair (HP:0003254)2.43359544
19Congenital stationary night blindness (HP:0007642)2.41519455
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.35924148
21Oligodactyly (HP:0012165)2.32483064
22Abnormality of the renal cortex (HP:0011035)2.31613333
23Retinal dysplasia (HP:0007973)2.31247773
24Oligodactyly (hands) (HP:0001180)2.30199313
25Optic nerve hypoplasia (HP:0000609)2.27077016
26Aplasia/Hypoplasia of the tibia (HP:0005772)2.24217103
27Renal cortical cysts (HP:0000803)2.23771653
28Chromsome breakage (HP:0040012)2.23282085
29Abnormality of cells of the erythroid lineage (HP:0012130)2.22115721
30Abnormality of chromosome stability (HP:0003220)2.20570441
31Abnormal number of erythroid precursors (HP:0012131)2.18346198
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16683507
33Abnormality of alanine metabolism (HP:0010916)2.16683507
34Hyperalaninemia (HP:0003348)2.16683507
35Patellar aplasia (HP:0006443)2.15447868
36Chronic hepatic failure (HP:0100626)2.14450231
37Meckel diverticulum (HP:0002245)2.12278129
38Abnormality of the pons (HP:0007361)2.12149513
39Microvesicular hepatic steatosis (HP:0001414)2.10277139
40Synostosis involving the elbow (HP:0003938)2.10029885
41Humeroradial synostosis (HP:0003041)2.10029885
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09833501
43Abolished electroretinogram (ERG) (HP:0000550)2.09176513
44Birth length less than 3rd percentile (HP:0003561)2.06828729
45Aplasia/Hypoplasia of the patella (HP:0006498)2.06681327
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05471958
47Medial flaring of the eyebrow (HP:0010747)2.05110131
48Hypoplasia of the radius (HP:0002984)2.02794444
49Abnormality of the ileum (HP:0001549)2.02535472
50Occipital encephalocele (HP:0002085)1.99952285
51Absent thumb (HP:0009777)1.98511665
52Sloping forehead (HP:0000340)1.97158310
53Hypoplasia of the pons (HP:0012110)1.95434463
54Anencephaly (HP:0002323)1.93683796
55Hyperglycinemia (HP:0002154)1.93633470
56Sclerocornea (HP:0000647)1.92657916
57Increased hepatocellular lipid droplets (HP:0006565)1.91994935
58Macrocytic anemia (HP:0001972)1.91343001
59Short tibia (HP:0005736)1.91103080
60Colon cancer (HP:0003003)1.89319498
61Impulsivity (HP:0100710)1.88811521
62Morphological abnormality of the inner ear (HP:0011390)1.88585742
63Abnormality of the preputium (HP:0100587)1.88116010
64Abnormality of the carotid arteries (HP:0005344)1.88106436
65Cystic liver disease (HP:0006706)1.85559100
66Congenital, generalized hypertrichosis (HP:0004540)1.84744651
67Gait imbalance (HP:0002141)1.82173850
68Abnormal ciliary motility (HP:0012262)1.81730787
69Abnormality of macular pigmentation (HP:0008002)1.79852501
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79144025
71Short 4th metacarpal (HP:0010044)1.79144025
72Abnormality of the lower motor neuron (HP:0002366)1.78664383
73Dandy-Walker malformation (HP:0001305)1.78345219
74Brushfield spots (HP:0001088)1.77265307
75Triphalangeal thumb (HP:0001199)1.76507802
76Pachygyria (HP:0001302)1.75449960
77Lipid accumulation in hepatocytes (HP:0006561)1.74792071
78Supernumerary spleens (HP:0009799)1.74366472
79Acute lymphatic leukemia (HP:0006721)1.72882586
80Pallor (HP:0000980)1.72023483
81Abnormality of the 4th metacarpal (HP:0010012)1.70834802
82Protruding tongue (HP:0010808)1.70485809
83Oculomotor apraxia (HP:0000657)1.69419104
84Attenuation of retinal blood vessels (HP:0007843)1.68395438
85Congenital primary aphakia (HP:0007707)1.67654892
86Myelodysplasia (HP:0002863)1.67373571
87Clubbing of toes (HP:0100760)1.67157372
88Congenital hepatic fibrosis (HP:0002612)1.66950336
89Prominent nasal bridge (HP:0000426)1.66869492
90Duplicated collecting system (HP:0000081)1.66312256
91Pendular nystagmus (HP:0012043)1.65617041
92Anomalous pulmonary venous return (HP:0010772)1.65458748
93Highly arched eyebrow (HP:0002553)1.65274125
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.65233525
95Hypothermia (HP:0002045)1.64533776
96Astigmatism (HP:0000483)1.64008068
97CNS hypomyelination (HP:0003429)1.63698155
98Male pseudohermaphroditism (HP:0000037)1.63505965
99Supernumerary bones of the axial skeleton (HP:0009144)1.63140742
100Postaxial foot polydactyly (HP:0001830)1.62957003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK5.64060718
2CASK3.54936118
3WEE13.52948118
4TSSK63.50179519
5WNK43.39493978
6BMPR1B2.86728971
7STK392.24322321
8ZAK2.18186584
9FRK2.15834339
10MAPK132.03663905
11NUAK11.99443778
12WNK31.97527206
13TAOK31.87938847
14CDC71.87671766
15MAPK151.54901324
16MAP4K21.48842134
17TLK11.47469480
18TRIM281.45502396
19MAP3K41.35520239
20TNIK1.33809742
21SRPK11.32630709
22DYRK21.31602844
23MKNK11.28826884
24ACVR1B1.24529334
25MKNK21.23854423
26PASK1.15710377
27BMPR21.15126626
28TGFBR11.12421833
29BUB11.10565996
30MARK11.03991788
31MAP3K121.03451945
32VRK11.03275323
33BRD41.01898447
34TRPM71.00671354
35AKT30.98719037
36ADRBK20.96287459
37TXK0.95992282
38OXSR10.93152931
39PRKCG0.92424847
40CCNB10.91338446
41INSRR0.91065599
42MAP2K20.89352314
43ERBB30.89177843
44PLK40.88852820
45RPS6KB20.86905214
46PAK30.86171825
47BRSK20.85796251
48IRAK20.83126778
49EIF2AK30.81233197
50CHEK20.81139448
51MAPKAPK50.81060276
52ATR0.80513547
53PLK10.80295456
54PLK30.78831359
55RPS6KA50.78514176
56MAPKAPK30.77399285
57GRK10.76025279
58NEK20.72166574
59IRAK10.69529237
60BCR0.69210668
61MAP2K70.67729235
62CSNK1G20.67535679
63NTRK30.67070602
64CDK30.65223704
65EPHA30.63961760
66PDK20.61679601
67PIM10.58894219
68PLK20.56327630
69ADRBK10.56076572
70PRKCQ0.54843689
71TTK0.54827736
72WNK10.51997605
73PINK10.51364621
74ATM0.50120782
75YES10.49093167
76PKN10.47287015
77CDK10.47194450
78CAMKK20.45453752
79EIF2AK20.44731339
80PRKCI0.43619455
81DYRK1A0.42024619
82BCKDK0.40585966
83PBK0.40535331
84CDK40.39909876
85SGK10.39640419
86AURKA0.39150211
87FLT30.38881864
88PRKACB0.37796370
89PRKCE0.36923844
90MARK30.36811059
91CDK80.36234200
92CSNK1G10.34174160
93STK160.33765680
94AURKB0.33111241
95CSNK2A20.32457892
96CSNK1E0.32183546
97IKBKB0.31833908
98CHEK10.31058132
99GSK3B0.30166622
100CSNK2A10.29182185

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.61713742
2Homologous recombination_Homo sapiens_hsa034403.05182933
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.98675384
4Fanconi anemia pathway_Homo sapiens_hsa034602.80084263
5Nicotine addiction_Homo sapiens_hsa050332.40691369
6Non-homologous end-joining_Homo sapiens_hsa034502.25878650
7RNA polymerase_Homo sapiens_hsa030202.16609704
8Protein export_Homo sapiens_hsa030602.13893047
9Spliceosome_Homo sapiens_hsa030402.02531632
10Nitrogen metabolism_Homo sapiens_hsa009102.00903466
11RNA degradation_Homo sapiens_hsa030181.96741297
12Phototransduction_Homo sapiens_hsa047441.95519202
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95436085
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93593420
15Basal transcription factors_Homo sapiens_hsa030221.89990984
16Nucleotide excision repair_Homo sapiens_hsa034201.89081529
17Oxidative phosphorylation_Homo sapiens_hsa001901.83837797
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82341922
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79935587
20Selenocompound metabolism_Homo sapiens_hsa004501.77691436
21Mismatch repair_Homo sapiens_hsa034301.71549714
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68125678
23RNA transport_Homo sapiens_hsa030131.67024434
24Parkinsons disease_Homo sapiens_hsa050121.65528040
25Base excision repair_Homo sapiens_hsa034101.63471935
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56352074
27DNA replication_Homo sapiens_hsa030301.50683134
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50400977
29Taste transduction_Homo sapiens_hsa047421.46251717
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.42425277
31Huntingtons disease_Homo sapiens_hsa050161.39107715
32Alcoholism_Homo sapiens_hsa050341.33518130
33Systemic lupus erythematosus_Homo sapiens_hsa053221.31382193
34Cell cycle_Homo sapiens_hsa041101.30181636
35Purine metabolism_Homo sapiens_hsa002301.21976537
36Pyrimidine metabolism_Homo sapiens_hsa002401.19498175
37Morphine addiction_Homo sapiens_hsa050321.14935837
38One carbon pool by folate_Homo sapiens_hsa006701.13229703
39Cardiac muscle contraction_Homo sapiens_hsa042601.12789237
40Olfactory transduction_Homo sapiens_hsa047401.07149613
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06074418
42Linoleic acid metabolism_Homo sapiens_hsa005911.04504282
43p53 signaling pathway_Homo sapiens_hsa041151.01126419
44Proteasome_Homo sapiens_hsa030501.00144897
45Peroxisome_Homo sapiens_hsa041460.99139799
46Glutamatergic synapse_Homo sapiens_hsa047240.92879053
47Alzheimers disease_Homo sapiens_hsa050100.90216386
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88690257
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87555568
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85580669
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84644832
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83922075
53Oocyte meiosis_Homo sapiens_hsa041140.83250074
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.82376820
55TGF-beta signaling pathway_Homo sapiens_hsa043500.76207611
56GABAergic synapse_Homo sapiens_hsa047270.75181473
57Steroid biosynthesis_Homo sapiens_hsa001000.75174487
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74031754
59mRNA surveillance pathway_Homo sapiens_hsa030150.72335111
60Butanoate metabolism_Homo sapiens_hsa006500.71327544
61Basal cell carcinoma_Homo sapiens_hsa052170.70533018
62Regulation of autophagy_Homo sapiens_hsa041400.69968616
63Dorso-ventral axis formation_Homo sapiens_hsa043200.66753842
64Hedgehog signaling pathway_Homo sapiens_hsa043400.65652877
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65068819
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65068596
67Caffeine metabolism_Homo sapiens_hsa002320.63998256
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59877709
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59815046
70Amphetamine addiction_Homo sapiens_hsa050310.58917825
71Propanoate metabolism_Homo sapiens_hsa006400.58333866
72Circadian entrainment_Homo sapiens_hsa047130.57210924
73Axon guidance_Homo sapiens_hsa043600.56728483
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56400718
75Ether lipid metabolism_Homo sapiens_hsa005650.55992072
76Fatty acid biosynthesis_Homo sapiens_hsa000610.55821150
77Hippo signaling pathway_Homo sapiens_hsa043900.55490710
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54770564
79Calcium signaling pathway_Homo sapiens_hsa040200.52934609
80Metabolic pathways_Homo sapiens_hsa011000.46874085
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45870475
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45305845
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.45262892
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45252612
85Cocaine addiction_Homo sapiens_hsa050300.44908381
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.44234968
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42606825
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41887378
89Collecting duct acid secretion_Homo sapiens_hsa049660.40833551
90Folate biosynthesis_Homo sapiens_hsa007900.39885712
91Tryptophan metabolism_Homo sapiens_hsa003800.38740569
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38362587
93Viral carcinogenesis_Homo sapiens_hsa052030.38178114
94Glycerolipid metabolism_Homo sapiens_hsa005610.37610251
95Sulfur relay system_Homo sapiens_hsa041220.36895844
96Serotonergic synapse_Homo sapiens_hsa047260.35893977
97Retinol metabolism_Homo sapiens_hsa008300.34968894
98Chemical carcinogenesis_Homo sapiens_hsa052040.31455965
99Insulin secretion_Homo sapiens_hsa049110.29914441
100Inositol phosphate metabolism_Homo sapiens_hsa005620.29355815

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