ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	6.48877884
2	regulation of retinoic acid receptor signaling pathway (GO:0048385)	5.72028048
3	cilium or flagellum-dependent cell motility (GO:0001539)	5.13847961
4	regulation of cilium movement (GO:0003352)	5.03644600
5	piRNA metabolic process (GO:0034587)	4.95815172
6	nonmotile primary cilium assembly (GO:0035058)	4.80581757
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.74486685
8	axonemal dynein complex assembly (GO:0070286)	4.58443721
9	centriole replication (GO:0007099)	4.30602098
10	epithelial cilium movement (GO:0003351)	4.23557271
11	intraciliary transport (GO:0042073)	4.19585724
12	cilium movement (GO:0003341)	4.17974268
13	righting reflex (GO:0060013)	4.17424293
14	meiotic cell cycle (GO:0051321)	4.13927065
15	centriole assembly (GO:0098534)	4.00140056
16	synapsis (GO:0007129)	3.97402881
17	left/right pattern formation (GO:0060972)	3.82451158
18	cullin deneddylation (GO:0010388)	3.74610297
19	regulation of microtubule-based movement (GO:0060632)	3.61415924
20	positive regulation of mitochondrial fission (GO:0090141)	3.45557470
21	protein deneddylation (GO:0000338)	3.44146326
22	acrosome reaction (GO:0007340)	3.35295894
23	multicellular organism reproduction (GO:0032504)	3.34394688
24	DNA methylation involved in gamete generation (GO:0043046)	3.34204041
25	pyrimidine dimer repair (GO:0006290)	3.27109391
26	cilium morphogenesis (GO:0060271)	3.21092681
27	microtubule anchoring (GO:0034453)	3.20190187
28	cilium assembly (GO:0042384)	3.17592738
29	motile cilium assembly (GO:0044458)	3.15409500
30	cilium organization (GO:0044782)	3.14957949
31	chromosome organization involved in meiosis (GO:0070192)	3.13941882
32	ganglion development (GO:0061548)	3.12447985
33	microtubule depolymerization (GO:0007019)	3.09119708
34	axoneme assembly (GO:0035082)	3.08253487
35	brain morphogenesis (GO:0048854)	3.04616913
36	nucleotide transmembrane transport (GO:1901679)	3.04177781
37	protein localization to cilium (GO:0061512)	3.03540577
38	male meiosis I (GO:0007141)	3.03166088
39	synaptonemal complex assembly (GO:0007130)	2.97053825
40	retinal cone cell development (GO:0046549)	2.94428539
41	attachment of spindle microtubules to kinetochore (GO:0008608)	2.92740406
42	glycosphingolipid biosynthetic process (GO:0006688)	2.89313989
43	male meiosis (GO:0007140)	2.84735278
44	DNA double-strand break processing (GO:0000729)	2.84372566
45	meiotic chromosome segregation (GO:0045132)	2.83674259
46	proteasome assembly (GO:0043248)	2.79838814
47	reflex (GO:0060004)	2.78678896
48	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.77614841
49	postsynaptic membrane organization (GO:0001941)	2.77272003
50	DNA integration (GO:0015074)	2.74745983
51	neural tube formation (GO:0001841)	2.70697322
52	presynaptic membrane assembly (GO:0097105)	2.68615193
53	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.67901849
54	hippocampus development (GO:0021766)	2.65225652
55	cellular component assembly involved in morphogenesis (GO:0010927)	2.64638648
56	positive regulation of protein homodimerization activity (GO:0090073)	2.64283719
57	regulation of acrosome reaction (GO:0060046)	2.62243945
58	histone H3-K9 demethylation (GO:0033169)	2.61675616
59	resolution of meiotic recombination intermediates (GO:0000712)	2.60516526
60	microtubule polymerization or depolymerization (GO:0031109)	2.60115227
61	phosphorelay signal transduction system (GO:0000160)	2.59905125
62	synaptonemal complex organization (GO:0070193)	2.59436200
63	olfactory bulb development (GO:0021772)	2.58983207
64	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.56129095
65	head development (GO:0060322)	2.55404260
66	peptidyl-lysine dimethylation (GO:0018027)	2.54697726
67	central nervous system neuron axonogenesis (GO:0021955)	2.53049112
68	regulation of coenzyme metabolic process (GO:0051196)	2.53032767
69	regulation of cofactor metabolic process (GO:0051193)	2.53032767
70	sperm motility (GO:0030317)	2.53029440
71	kidney mesenchyme development (GO:0072074)	2.52395046
72	sperm-egg recognition (GO:0035036)	2.50879565
73	cytoplasmic microtubule organization (GO:0031122)	2.48845415
74	inositol phosphate catabolic process (GO:0071545)	2.47483402
75	sperm capacitation (GO:0048240)	2.45616993
76	mitochondrial fission (GO:0000266)	2.44260073
77	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.43939012
78	microtubule nucleation (GO:0007020)	2.43816363
79	lipid particle organization (GO:0034389)	2.43052436
80	binding of sperm to zona pellucida (GO:0007339)	2.41063915
81	microtubule bundle formation (GO:0001578)	2.40668783
82	gene silencing by RNA (GO:0031047)	2.40638032
83	diterpenoid biosynthetic process (GO:0016102)	2.40411856
84	sialylation (GO:0097503)	2.40085461
85	regulation of timing of cell differentiation (GO:0048505)	2.38300890
86	microtubule-based movement (GO:0007018)	2.37851442
87	intra-S DNA damage checkpoint (GO:0031573)	2.35825415
88	spermatid development (GO:0007286)	2.35088826
89	pyrimidine nucleobase catabolic process (GO:0006208)	2.32626217
90	regulation of DNA endoreduplication (GO:0032875)	2.32620435
91	coenzyme catabolic process (GO:0009109)	2.31689224
92	photoreceptor cell differentiation (GO:0046530)	2.31426305
93	eye photoreceptor cell differentiation (GO:0001754)	2.31426305
94	sister chromatid cohesion (GO:0007062)	2.31323016
95	positive regulation of cell size (GO:0045793)	2.30095485
96	appendage development (GO:0048736)	2.29588461
97	limb development (GO:0060173)	2.29588461
98	ubiquinone biosynthetic process (GO:0006744)	2.29141749
99	regulation of development, heterochronic (GO:0040034)	2.29009614
100	embryonic body morphogenesis (GO:0010172)	2.28702927

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.68434638
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.51715219
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.11805540
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.96052751
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.83621394
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.53022947
7	FUS_26573619_Chip-Seq_HEK293_Human	2.52130898
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.48851979
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.44400309
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.43753701
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.42034906
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.33772864
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.10845466
14	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.09277361
15	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.07182527
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.06611806
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97623568
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.95810422
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.93488489
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.84630449
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.82809045
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.82809045
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.81428365
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79484154
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.78559158
26	EWS_26573619_Chip-Seq_HEK293_Human	1.73909501
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.72408909
28	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.70655965
29	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.70592267
30	STAT3_23295773_ChIP-Seq_U87_Human	1.69588046
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.62835064
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.60014974
33	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.59877768
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.58894725
35	P300_19829295_ChIP-Seq_ESCs_Human	1.57850682
36	AR_25329375_ChIP-Seq_VCAP_Human	1.57453063
37	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.57390865
38	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.56472681
39	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.54561757
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.54320156
41	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.49643174
42	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49449514
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.49285770
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49285770
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.47706148
46	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.47593886
47	VDR_22108803_ChIP-Seq_LS180_Human	1.46302957
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44355857
49	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.43074386
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42459407
51	* SMAD_19615063_ChIP-ChIP_OVARY_Human	1.39014027
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37909133
53	TCF4_23295773_ChIP-Seq_U87_Human	1.37637251
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.34709065
55	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.33519867
56	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.32509090
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31211688
58	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.29364074
59	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.28586861
60	SOX9_26525672_Chip-Seq_HEART_Mouse	1.28347642
61	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.28149731
62	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.27953794
63	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.27608586
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27485271
65	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.27413187
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.26180423
67	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.22990080
68	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.22622101
69	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.22588589
70	TP53_18474530_ChIP-ChIP_U2OS_Human	1.20522640
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19211480
72	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.18556731
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18157234
74	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.17942982
75	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.14732839
76	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13226096
77	VDR_23849224_ChIP-Seq_CD4+_Human	1.12016260
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09686732
79	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.09681228
80	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.09353975
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08808605
82	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.07772277
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06928276
84	GABP_19822575_ChIP-Seq_HepG2_Human	1.06424605
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04978212
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03432567
87	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.02678694
88	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.01750240
89	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.00680235
90	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.98550364
91	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98087898
92	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.97795801
93	KDM2B_26808549_Chip-Seq_REH_Human	0.97237338
94	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96407913
95	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.95719286
96	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93875505
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.93337860
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.93090494
99	TBL1_22424771_ChIP-Seq_293T_Human	0.92071069
100	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91632232

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	4.02904768
2	MP0008789_abnormal_olfactory_epithelium	3.59951761
3	MP0005499_abnormal_olfactory_system	2.96235375
4	MP0005394_taste/olfaction_phenotype	2.96235375
5	MP0002102_abnormal_ear_morphology	2.90142057
6	MP0001984_abnormal_olfaction	2.77000647
7	MP0002638_abnormal_pupillary_reflex	2.64932324
8	MP0003136_yellow_coat_color	2.43590084
9	MP0001529_abnormal_vocalization	2.31213417
10	MP0000751_myopathy	2.19349549
11	MP0000427_abnormal_hair_cycle	2.10225691
12	MP0008058_abnormal_DNA_repair	2.03625449
13	MP0005248_abnormal_Harderian_gland	2.02887899
14	MP0004133_heterotaxia	2.02535028
15	MP0004043_abnormal_pH_regulation	1.97673014
16	MP0008877_abnormal_DNA_methylation	1.83475870
17	MP0002822_catalepsy	1.81749110
18	MP0000569_abnormal_digit_pigmentation	1.81362320
19	MP0005423_abnormal_somatic_nervous	1.80682352
20	MP0003718_maternal_effect	1.77215692
21	MP0005253_abnormal_eye_physiology	1.69210604
22	MP0001986_abnormal_taste_sensitivity	1.65919925
23	MP0010386_abnormal_urinary_bladder	1.64838070
24	MP0003283_abnormal_digestive_organ	1.64192537
25	MP0003646_muscle_fatigue	1.60546624
26	MP0008057_abnormal_DNA_replication	1.59365615
27	MP0001929_abnormal_gametogenesis	1.50323365
28	MP0002837_dystrophic_cardiac_calcinosis	1.47905604
29	MP0008260_abnormal_autophagy	1.47738271
30	MP0005174_abnormal_tail_pigmentation	1.47159922
31	MP0000647_abnormal_sebaceous_gland	1.46357137
32	MP0002233_abnormal_nose_morphology	1.43962720
33	MP0000015_abnormal_ear_pigmentation	1.38790147
34	MP0002210_abnormal_sex_determination	1.38183825
35	MP0004215_abnormal_myocardial_fiber	1.35041935
36	MP0000778_abnormal_nervous_system	1.28388122
37	MP0000372_irregular_coat_pigmentation	1.26297312
38	MP0005220_abnormal_exocrine_pancreas	1.23577316
39	MP0002095_abnormal_skin_pigmentation	1.23024360
40	MP0005367_renal/urinary_system_phenotyp	1.20415883
41	MP0000516_abnormal_urinary_system	1.20415883
42	MP0008995_early_reproductive_senescence	1.20323844
43	MP0000749_muscle_degeneration	1.18258930
44	MP0003950_abnormal_plasma_membrane	1.16603482
45	MP0005410_abnormal_fertilization	1.14517499
46	MP0002928_abnormal_bile_duct	1.12418221
47	MP0001486_abnormal_startle_reflex	1.11619945
48	MP0002653_abnormal_ependyma_morphology	1.11382208
49	MP0003698_abnormal_male_reproductive	1.10036874
50	MP0001188_hyperpigmentation	1.08652709
51	MP0005257_abnormal_intraocular_pressure	1.08449674
52	MP0001502_abnormal_circadian_rhythm	1.06313348
53	MP0006276_abnormal_autonomic_nervous	1.06293046
54	MP0005451_abnormal_body_composition	1.05356787
55	MP0004142_abnormal_muscle_tone	1.02530875
56	MP0002735_abnormal_chemical_nociception	1.01742093
57	MP0002909_abnormal_adrenal_gland	1.01523635
58	MP0002734_abnormal_mechanical_nocicepti	1.01393937
59	MP0005395_other_phenotype	1.00719737
60	MP0010094_abnormal_chromosome_stability	0.97639055
61	MP0003755_abnormal_palate_morphology	0.97556944
62	MP0000747_muscle_weakness	0.96814347
63	MP0005645_abnormal_hypothalamus_physiol	0.95541703
64	MP0000013_abnormal_adipose_tissue	0.95157543
65	MP0002938_white_spotting	0.91615314
66	MP0001485_abnormal_pinna_reflex	0.91349183
67	MP0000049_abnormal_middle_ear	0.90010674
68	MP0000653_abnormal_sex_gland	0.89126515
69	MP0002127_abnormal_cardiovascular_syste	0.88967981
70	MP0003252_abnormal_bile_duct	0.88522732
71	MP0004270_analgesia	0.88278698
72	MP0001145_abnormal_male_reproductive	0.88187810
73	MP0000534_abnormal_ureter_morphology	0.86557404
74	MP0000383_abnormal_hair_follicle	0.86262016
75	MP0002177_abnormal_outer_ear	0.85763786
76	MP0009046_muscle_twitch	0.84607661
77	MP0005551_abnormal_eye_electrophysiolog	0.84526411
78	MP0006035_abnormal_mitochondrial_morpho	0.83046481
79	MP0005391_vision/eye_phenotype	0.82782858
80	MP0003786_premature_aging	0.82270696
81	MP0003221_abnormal_cardiomyocyte_apopto	0.80793332
82	MP0004885_abnormal_endolymph	0.79643648
83	MP0003935_abnormal_craniofacial_develop	0.78837664
84	MP0001905_abnormal_dopamine_level	0.77891979
85	MP0002160_abnormal_reproductive_system	0.76975448
86	MP0004147_increased_porphyrin_level	0.76893235
87	MP0001270_distended_abdomen	0.76397558
88	MP0004145_abnormal_muscle_electrophysio	0.75492743
89	MP0002067_abnormal_sensory_capabilities	0.75476227
90	MP0006072_abnormal_retinal_apoptosis	0.74689854
91	MP0005408_hypopigmentation	0.73847417
92	MP0004233_abnormal_muscle_weight	0.72979398
93	MP0003385_abnormal_body_wall	0.72133129
94	MP0004085_abnormal_heartbeat	0.71861985
95	MP0003077_abnormal_cell_cycle	0.71679113
96	MP0002161_abnormal_fertility/fecundity	0.70435825
97	MP0005187_abnormal_penis_morphology	0.68495266
98	MP0004811_abnormal_neuron_physiology	0.68314186
99	MP0009697_abnormal_copulation	0.67412790
100	MP0010678_abnormal_skin_adnexa	0.66717989

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	5.93297819
2	Medial flaring of the eyebrow (HP:0010747)	4.29148411
3	Gait imbalance (HP:0002141)	3.92276320
4	Nephrogenic diabetes insipidus (HP:0009806)	3.89974419
5	Abnormal respiratory motile cilium morphology (HP:0005938)	3.87955642
6	Abnormal respiratory epithelium morphology (HP:0012253)	3.87955642
7	Congenital primary aphakia (HP:0007707)	3.84634336
8	Abnormal ciliary motility (HP:0012262)	3.78382953
9	Abnormal respiratory motile cilium physiology (HP:0012261)	3.61779012
10	Rhinitis (HP:0012384)	3.59395764
11	Male infertility (HP:0003251)	3.53493644
12	Chronic hepatic failure (HP:0100626)	3.49293995
13	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.39204052
14	Abnormality of midbrain morphology (HP:0002418)	3.23370817
15	Molar tooth sign on MRI (HP:0002419)	3.23370817
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.19223763
17	Absent/shortened dynein arms (HP:0200106)	3.19223763
18	Shoulder girdle muscle weakness (HP:0003547)	3.00895372
19	Gaze-evoked nystagmus (HP:0000640)	2.92871697
20	Tubulointerstitial abnormality (HP:0001969)	2.90257654
21	Poor coordination (HP:0002370)	2.82658047
22	Genital tract atresia (HP:0001827)	2.81081874
23	Pancreatic fibrosis (HP:0100732)	2.72695966
24	Vaginal atresia (HP:0000148)	2.70269687
25	Nephronophthisis (HP:0000090)	2.64496009
26	Dysmetric saccades (HP:0000641)	2.62671494
27	Abnormality of the renal medulla (HP:0100957)	2.59770550
28	Abnormality of the hip-girdle musculature (HP:0001445)	2.43322917
29	Abnormality of the musculature of the pelvis (HP:0001469)	2.43322917
30	Congenital sensorineural hearing impairment (HP:0008527)	2.39765722
31	Infertility (HP:0000789)	2.39648520
32	Oculomotor apraxia (HP:0000657)	2.33391672
33	Aplasia/Hypoplasia of the lens (HP:0008063)	2.30474172
34	Congenital hepatic fibrosis (HP:0002612)	2.29169107
35	Drooling (HP:0002307)	2.26277426
36	Poikiloderma (HP:0001029)	2.25311134
37	Postaxial hand polydactyly (HP:0001162)	2.17997558
38	Pelvic girdle muscle weakness (HP:0003749)	2.16292671
39	Hip dysplasia (HP:0001385)	2.15997259
40	True hermaphroditism (HP:0010459)	2.15113184
41	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.11372069
42	Increased circulating renin level (HP:0000848)	2.09986786
43	Hyperventilation (HP:0002883)	2.07547541
44	Progressive inability to walk (HP:0002505)	2.04536122
45	Hyperactive renin-angiotensin system (HP:0000841)	2.04413849
46	Bronchiectasis (HP:0002110)	2.04106076
47	Hypokalemic alkalosis (HP:0001949)	2.04049596
48	Occipital encephalocele (HP:0002085)	2.02784972
49	Excessive salivation (HP:0003781)	2.01370758
50	Intestinal atresia (HP:0011100)	2.00724800
51	Supernumerary spleens (HP:0009799)	1.99253663
52	Fetal akinesia sequence (HP:0001989)	1.97234307
53	Prominent nasal bridge (HP:0000426)	1.97071067
54	Limb-girdle muscle atrophy (HP:0003797)	1.95889990
55	Sensorimotor neuropathy (HP:0007141)	1.92959336
56	Attenuation of retinal blood vessels (HP:0007843)	1.91697985
57	Pancreatic cysts (HP:0001737)	1.91235020
58	Abnormality of chloride homeostasis (HP:0011422)	1.91087308
59	Rimmed vacuoles (HP:0003805)	1.86810152
60	Abnormality of DNA repair (HP:0003254)	1.85001273
61	Entropion (HP:0000621)	1.84937729
62	Postaxial foot polydactyly (HP:0001830)	1.84383970
63	Bony spicule pigmentary retinopathy (HP:0007737)	1.83996205
64	Hyperkalemia (HP:0002153)	1.83994572
65	Median cleft lip (HP:0000161)	1.82348037
66	Rectovaginal fistula (HP:0000143)	1.80812169
67	Rectal fistula (HP:0100590)	1.80812169
68	Lower limb hyperreflexia (HP:0002395)	1.79714989
69	Abnormality of the fovea (HP:0000493)	1.77851484
70	Absent speech (HP:0001344)	1.76156277
71	Dysdiadochokinesis (HP:0002075)	1.75562954
72	Hyperaldosteronism (HP:0000859)	1.75496329
73	Fibular hypoplasia (HP:0003038)	1.74866386
74	Intellectual disability, moderate (HP:0002342)	1.72384370
75	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.70531234
76	Abnormality of alanine metabolism (HP:0010916)	1.70531234
77	Hyperalaninemia (HP:0003348)	1.70531234
78	Astigmatism (HP:0000483)	1.70454429
79	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.67347041
80	Specific learning disability (HP:0001328)	1.66999665
81	Methylmalonic acidemia (HP:0002912)	1.66932349
82	Aganglionic megacolon (HP:0002251)	1.65010642
83	Abnormality of the labia minora (HP:0012880)	1.64598368
84	Abnormality of the metopic suture (HP:0005556)	1.64284361
85	Cutaneous melanoma (HP:0012056)	1.64243438
86	Volvulus (HP:0002580)	1.64161973
87	Facial hemangioma (HP:0000329)	1.63374258
88	Chorioretinal atrophy (HP:0000533)	1.61795411
89	Facial cleft (HP:0002006)	1.61700274
90	Horizontal nystagmus (HP:0000666)	1.61608210
91	Left ventricular hypertrophy (HP:0001712)	1.61083136
92	Hypoplastic nipples (HP:0002557)	1.58484166
93	Limb-girdle muscle weakness (HP:0003325)	1.56839191
94	Action tremor (HP:0002345)	1.55574301
95	Abnormality of the renal cortex (HP:0011035)	1.55214509
96	Azoospermia (HP:0000027)	1.55082321
97	Short foot (HP:0001773)	1.54627014
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.54456696
99	Hypokinesia (HP:0002375)	1.54083609
100	Ankle clonus (HP:0011448)	1.53713168

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	5.41082122
2	MAP3K4	3.64747506
3	BCR	3.09612252
4	MAP2K7	2.86185811
5	AKT3	2.81464131
6	TAF1	2.68063702
7	CASK	2.53028429
8	MAPK15	2.50092040
9	ERBB3	2.42235831
10	NEK6	2.38617155
11	TRIM28	2.11064373
12	NEK1	2.06552402
13	PNCK	1.88516624
14	FRK	1.85097743
15	MAPK13	1.78498116
16	SRPK1	1.75778144
17	STK38L	1.73647632
18	CCNB1	1.63292902
19	ACVR1B	1.59473153
20	MARK1	1.46482269
21	NEK9	1.40859432
22	CDK19	1.35914421
23	PAK3	1.35905473
24	PTK2B	1.34657242
25	PLK4	1.31911578
26	PINK1	1.27415770
27	SGK2	1.24141338
28	CSNK1G1	1.20488761
29	LMTK2	1.18687786
30	MET	1.18075467
31	PRKD3	1.16629165
32	PRKD2	1.15420894
33	MAP4K2	1.14891417
34	BMPR1B	1.12372203
35	CSNK1A1L	1.08866187
36	OBSCN	1.04683101
37	CSNK1G2	1.03893799
38	STK16	1.02242700
39	CSNK1G3	1.01782759
40	PLK2	0.99609339
41	WNK3	0.94990750
42	MUSK	0.92014658
43	MAP2K4	0.85968671
44	BCKDK	0.85684692
45	CAMK1G	0.84822917
46	NTRK2	0.84583272
47	PKN1	0.83779018
48	SGK223	0.81285629
49	SGK494	0.81285629
50	DYRK1A	0.79829307
51	MST4	0.79035423
52	FGR	0.74618991
53	PRKCE	0.71822641
54	SGK3	0.68761382
55	VRK1	0.68358423
56	EPHA3	0.67288639
57	PAK6	0.66897765
58	OXSR1	0.65041674
59	STK38	0.63096986
60	BRAF	0.61293849
61	ATR	0.60336263
62	KSR1	0.58742870
63	ROCK1	0.57623444
64	CHEK1	0.57349869
65	RPS6KB1	0.55947671
66	DDR2	0.55705537
67	PLK1	0.54965250
68	MKNK2	0.54563474
69	TTK	0.53898825
70	NEK2	0.53187296
71	PLK3	0.51752705
72	CDK14	0.51339063
73	CDK18	0.51125920
74	CDK11A	0.50136372
75	TAOK1	0.48482514
76	ATM	0.47982510
77	CDK15	0.44660200
78	PRKACB	0.44437009
79	BRD4	0.41847348
80	PHKG2	0.41451818
81	PHKG1	0.41451818
82	MAP3K5	0.40793997
83	WNK1	0.40499121
84	MAP3K7	0.39803806
85	PRKCG	0.39797266
86	FER	0.38442141
87	MARK2	0.36190558
88	CAMKK2	0.35630499
89	EPHA4	0.34702060
90	DYRK3	0.34468392
91	CAMK4	0.33477421
92	CSNK1D	0.32501934
93	PRKG1	0.32041475
94	AURKA	0.31774722
95	PRKAA1	0.31713481
96	MINK1	0.30395587
97	MKNK1	0.30352041
98	PRKD1	0.29082551
99	CDK5	0.28032173
100	PRKACA	0.27892113

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Propanoate metabolism_Homo sapiens_hsa00640	3.20355021
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.18803977
3	Basal transcription factors_Homo sapiens_hsa03022	2.75194461
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.74861770
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.64893955
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.56160992
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.47158441
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.32650479
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.32443314
10	Circadian rhythm_Homo sapiens_hsa04710	2.00554574
11	Collecting duct acid secretion_Homo sapiens_hsa04966	1.99610813
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.83205604
13	Oocyte meiosis_Homo sapiens_hsa04114	1.68882963
14	mRNA surveillance pathway_Homo sapiens_hsa03015	1.65034136
15	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.63615156
16	ABC transporters_Homo sapiens_hsa02010	1.56158807
17	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.54050530
18	beta-Alanine metabolism_Homo sapiens_hsa00410	1.52819973
19	Butanoate metabolism_Homo sapiens_hsa00650	1.52076399
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.50432852
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.50079952
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.49809560
23	Cell cycle_Homo sapiens_hsa04110	1.49200219
24	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.41046003
25	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.36213443
26	Homologous recombination_Homo sapiens_hsa03440	1.31534890
27	Base excision repair_Homo sapiens_hsa03410	1.29957491
28	RNA polymerase_Homo sapiens_hsa03020	1.27307903
29	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.26805779
30	Taste transduction_Homo sapiens_hsa04742	1.21084778
31	Protein export_Homo sapiens_hsa03060	1.20627740
32	Lysine degradation_Homo sapiens_hsa00310	1.10556883
33	Vibrio cholerae infection_Homo sapiens_hsa05110	0.98203812
34	Gap junction_Homo sapiens_hsa04540	0.96509007
35	Fatty acid metabolism_Homo sapiens_hsa01212	0.96340074
36	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.95686458
37	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.94403297
38	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.93539591
39	p53 signaling pathway_Homo sapiens_hsa04115	0.92578744
40	Cocaine addiction_Homo sapiens_hsa05030	0.92419613
41	Pyruvate metabolism_Homo sapiens_hsa00620	0.91912347
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.91348681
43	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.91075364
44	Insulin secretion_Homo sapiens_hsa04911	0.90385886
45	Peroxisome_Homo sapiens_hsa04146	0.89876733
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.86297140
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84888085
48	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.84213072
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83031766
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.81369987
51	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79270090
52	Mismatch repair_Homo sapiens_hsa03430	0.79118138
53	Huntingtons disease_Homo sapiens_hsa05016	0.77502486
54	Proteasome_Homo sapiens_hsa03050	0.77199719
55	Regulation of autophagy_Homo sapiens_hsa04140	0.71309511
56	Nicotine addiction_Homo sapiens_hsa05033	0.70887770
57	Fatty acid elongation_Homo sapiens_hsa00062	0.70701185
58	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.70251829
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68577026
60	Sphingolipid metabolism_Homo sapiens_hsa00600	0.68491575
61	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.68415885
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.67626750
63	Purine metabolism_Homo sapiens_hsa00230	0.67155045
64	RNA transport_Homo sapiens_hsa03013	0.66958064
65	Dopaminergic synapse_Homo sapiens_hsa04728	0.65613438
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65455932
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.64268250
68	Tyrosine metabolism_Homo sapiens_hsa00350	0.63135331
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61399201
70	Melanoma_Homo sapiens_hsa05218	0.59492928
71	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.59117164
72	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.58047148
73	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.57634636
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57387688
75	Morphine addiction_Homo sapiens_hsa05032	0.57171267
76	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.56523362
77	Salivary secretion_Homo sapiens_hsa04970	0.56156164
78	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.55961950
79	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.52390510
80	GABAergic synapse_Homo sapiens_hsa04727	0.50477276
81	RNA degradation_Homo sapiens_hsa03018	0.49274393
82	mTOR signaling pathway_Homo sapiens_hsa04150	0.48607227
83	Metabolic pathways_Homo sapiens_hsa01100	0.48194691
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.47495415
85	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.46390153
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46158649
87	Circadian entrainment_Homo sapiens_hsa04713	0.45043610
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42185585
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.42135185
90	Long-term depression_Homo sapiens_hsa04730	0.42003468
91	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.41559029
92	Olfactory transduction_Homo sapiens_hsa04740	0.41232785
93	Phototransduction_Homo sapiens_hsa04744	0.39260022
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.37505864
95	Fatty acid degradation_Homo sapiens_hsa00071	0.37192705
96	Wnt signaling pathway_Homo sapiens_hsa04310	0.37017636
97	Endometrial cancer_Homo sapiens_hsa05213	0.35270621
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34533795
99	Alcoholism_Homo sapiens_hsa05034	0.34193358
100	DNA replication_Homo sapiens_hsa03030	0.33818604

ZNF132

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »