ZNF134

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.55457373
2nuclear pore organization (GO:0006999)4.28752547
3DNA double-strand break processing (GO:0000729)4.24933617
4regulation of posttranscriptional gene silencing (GO:0060147)4.15487414
5regulation of gene silencing by miRNA (GO:0060964)4.15487414
6regulation of gene silencing by RNA (GO:0060966)4.15487414
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.86670877
8negative regulation of translation, ncRNA-mediated (GO:0040033)3.86670877
9regulation of translation, ncRNA-mediated (GO:0045974)3.86670877
10negative regulation of DNA-dependent DNA replication (GO:2000104)3.85190988
11mitotic sister chromatid cohesion (GO:0007064)3.82102492
12regulation of helicase activity (GO:0051095)3.76681422
13pyrimidine nucleobase catabolic process (GO:0006208)3.63083038
14pre-miRNA processing (GO:0031054)3.60587182
15chromatin remodeling at centromere (GO:0031055)3.56397708
16CENP-A containing nucleosome assembly (GO:0034080)3.46466116
17negative regulation of DNA recombination (GO:0045910)3.46307728
18pore complex assembly (GO:0046931)3.36175950
19somite rostral/caudal axis specification (GO:0032525)3.34909902
20regulation of histone H3-K9 methylation (GO:0051570)3.33005105
21regulation of DNA methylation (GO:0044030)3.29499070
22establishment of integrated proviral latency (GO:0075713)3.26672793
23negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.17408038
24negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.17408038
25negative regulation of mitotic sister chromatid segregation (GO:0033048)3.17408038
26negative regulation of mitotic sister chromatid separation (GO:2000816)3.17408038
27negative regulation of sister chromatid segregation (GO:0033046)3.17408038
28histone exchange (GO:0043486)3.17351116
29regulation of centriole replication (GO:0046599)3.12777597
30mitotic spindle checkpoint (GO:0071174)3.11788899
31regulation of mitotic spindle checkpoint (GO:1903504)3.11368573
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.11368573
33negative regulation of chromosome segregation (GO:0051985)3.09777605
34spindle checkpoint (GO:0031577)3.08065265
35regulation of DNA endoreduplication (GO:0032875)3.07491212
36regulation of meiosis I (GO:0060631)3.03349261
37regulation of chromatin silencing (GO:0031935)2.98068648
38protein localization to kinetochore (GO:0034501)2.94751774
39presynaptic membrane assembly (GO:0097105)2.93953796
40negative regulation of histone methylation (GO:0031061)2.93568505
41positive regulation of mitochondrial fission (GO:0090141)2.91959608
42regulation of nuclear cell cycle DNA replication (GO:0033262)2.91078572
43DNA replication-independent nucleosome assembly (GO:0006336)2.90272453
44DNA replication-independent nucleosome organization (GO:0034724)2.90272453
45IMP biosynthetic process (GO:0006188)2.89793449
46regulation of telomere maintenance via telomerase (GO:0032210)2.83870831
47mitotic metaphase plate congression (GO:0007080)2.83462226
48mitotic spindle assembly checkpoint (GO:0007094)2.83368947
49ncRNA catabolic process (GO:0034661)2.83279408
50RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82441495
51acrosome assembly (GO:0001675)2.82375018
52regulation of mitotic metaphase/anaphase transition (GO:0030071)2.81636246
53regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.81636246
54mitotic nuclear envelope disassembly (GO:0007077)2.81558619
55negative regulation of gene silencing (GO:0060969)2.81350626
56somatic diversification of immune receptors via somatic mutation (GO:0002566)2.80989384
57somatic hypermutation of immunoglobulin genes (GO:0016446)2.80989384
58centriole replication (GO:0007099)2.79917724
59nuclear envelope disassembly (GO:0051081)2.78344055
60membrane disassembly (GO:0030397)2.78344055
61regulation of gene silencing (GO:0060968)2.77089503
62DNA replication-dependent nucleosome assembly (GO:0006335)2.76828941
63DNA replication-dependent nucleosome organization (GO:0034723)2.76828941
64spindle assembly checkpoint (GO:0071173)2.76381653
65regulation of sister chromatid segregation (GO:0033045)2.76219765
66regulation of mitotic sister chromatid separation (GO:0010965)2.76219765
67regulation of mitotic sister chromatid segregation (GO:0033047)2.76219765
68metaphase plate congression (GO:0051310)2.76038732
69cell fate commitment involved in formation of primary germ layer (GO:0060795)2.72911731
70non-recombinational repair (GO:0000726)2.72154672
71double-strand break repair via nonhomologous end joining (GO:0006303)2.72154672
72ATP-dependent chromatin remodeling (GO:0043044)2.69861265
73regulation of RNA export from nucleus (GO:0046831)2.69632770
74negative regulation of fibroblast apoptotic process (GO:2000270)2.69532531
75resolution of meiotic recombination intermediates (GO:0000712)2.68650642
76IMP metabolic process (GO:0046040)2.68593738
77head development (GO:0060322)2.68064924
78positive regulation of mRNA processing (GO:0050685)2.64247145
79protein localization to chromosome, centromeric region (GO:0071459)2.61299412
80neural tube formation (GO:0001841)2.57130569
81mRNA splice site selection (GO:0006376)2.56405809
82regulation of telomere maintenance (GO:0032204)2.54791097
83negative regulation of mRNA processing (GO:0050686)2.54052861
84presynaptic membrane organization (GO:0097090)2.53432452
85negative regulation of RNA splicing (GO:0033119)2.52932655
86gonadal mesoderm development (GO:0007506)2.52545384
87negative regulation of mitosis (GO:0045839)2.50679745
88establishment of viral latency (GO:0019043)2.49706245
89single strand break repair (GO:0000012)2.49310650
90nucleobase catabolic process (GO:0046113)2.48839982
91positive regulation of histone H3-K4 methylation (GO:0051571)2.48263522
92pyrimidine dimer repair (GO:0006290)2.47957425
93negative regulation of meiosis (GO:0045835)2.47540943
94mitotic G2/M transition checkpoint (GO:0044818)2.47525314
95postreplication repair (GO:0006301)2.47014279
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.46606196
97DNA catabolic process, exonucleolytic (GO:0000738)2.45118767
98attachment of spindle microtubules to kinetochore (GO:0008608)2.44475690
99negative regulation of nuclear division (GO:0051784)2.44380579
100response to X-ray (GO:0010165)2.42974952

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.39122984
2E2F7_22180533_ChIP-Seq_HELA_Human2.97553161
3ZNF274_21170338_ChIP-Seq_K562_Hela2.93721730
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75639882
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.59087376
6IGF1R_20145208_ChIP-Seq_DFB_Human2.58589985
7EWS_26573619_Chip-Seq_HEK293_Human2.49691850
8TAF15_26573619_Chip-Seq_HEK293_Human2.41870234
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.37512414
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.37252196
11FUS_26573619_Chip-Seq_HEK293_Human2.36963498
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34678162
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.30062842
14* EST1_17652178_ChIP-ChIP_JURKAT_Human2.22380224
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.18549611
16ELK1_19687146_ChIP-ChIP_HELA_Human2.18392586
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17480060
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12290612
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.10627057
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.10627057
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.10627057
22GBX2_23144817_ChIP-Seq_PC3_Human2.09826149
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05384056
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04986833
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95062963
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90953347
27P300_19829295_ChIP-Seq_ESCs_Human1.90855012
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89341281
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.86519558
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77870534
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77692011
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76532391
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76332048
34IRF1_19129219_ChIP-ChIP_H3396_Human1.72431097
35SOX2_16153702_ChIP-ChIP_HESCs_Human1.67542489
36* VDR_23849224_ChIP-Seq_CD4+_Human1.65499717
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.65169581
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65061395
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62894882
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.62138250
41EZH2_22144423_ChIP-Seq_EOC_Human1.56756787
42NANOG_16153702_ChIP-ChIP_HESCs_Human1.56678284
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56525896
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54936006
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52410946
46VDR_22108803_ChIP-Seq_LS180_Human1.48303087
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.45662950
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42965083
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42820610
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42820610
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.42301479
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40857284
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39527128
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39129859
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38494616
56FOXP3_21729870_ChIP-Seq_TREG_Human1.37342919
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36128002
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35784234
59MYC_18940864_ChIP-ChIP_HL60_Human1.35663646
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35273858
61* ETS1_20019798_ChIP-Seq_JURKAT_Human1.35199487
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.33652313
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.32730882
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31885940
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31599926
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.30054479
67SMAD4_21799915_ChIP-Seq_A2780_Human1.28200974
68FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27840050
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27768087
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23747758
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22364484
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.20296223
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18584088
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18520768
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15708654
76NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14966689
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12878707
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12788487
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11676205
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10665756
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08137259
82STAT3_23295773_ChIP-Seq_U87_Human1.07724583
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06795145
84RNF2_27304074_Chip-Seq_NSC_Mouse1.06534196
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05889192
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.05488521
87POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05136979
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.04645680
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02742791
90TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02477045
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02018064
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01682107
93CBP_20019798_ChIP-Seq_JUKART_Human1.01497785
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01497785
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01026236
96TTF2_22483619_ChIP-Seq_HELA_Human1.00860488
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99748530
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99456975
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98998510
100SOX9_26525672_Chip-Seq_HEART_Mouse0.98752486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry3.79598481
2MP0008877_abnormal_DNA_methylation3.55952210
3MP0008057_abnormal_DNA_replication3.14206493
4MP0003693_abnormal_embryo_hatching2.76358737
5MP0008058_abnormal_DNA_repair2.70661311
6MP0005499_abnormal_olfactory_system2.59611577
7MP0005394_taste/olfaction_phenotype2.59611577
8MP0006292_abnormal_olfactory_placode2.44742891
9MP0001293_anophthalmia2.37908601
10MP0003122_maternal_imprinting2.37599691
11MP0002102_abnormal_ear_morphology2.31147341
12MP0004957_abnormal_blastocyst_morpholog2.24706232
13MP0010094_abnormal_chromosome_stability2.23564868
14MP0008789_abnormal_olfactory_epithelium2.19004737
15MP0001188_hyperpigmentation2.13832779
16MP0003121_genomic_imprinting2.13412111
17MP0003111_abnormal_nucleus_morphology2.11329502
18MP0003787_abnormal_imprinting1.97791626
19MP0003941_abnormal_skin_development1.97153071
20MP0003718_maternal_effect1.96883247
21MP0003119_abnormal_digestive_system1.96496008
22MP0003567_abnormal_fetal_cardiomyocyte1.96440142
23MP0001984_abnormal_olfaction1.95643610
24MP0008932_abnormal_embryonic_tissue1.85684521
25MP0004133_heterotaxia1.84301675
26MP0003077_abnormal_cell_cycle1.80634119
27MP0002233_abnormal_nose_morphology1.66054291
28MP0003937_abnormal_limbs/digits/tail_de1.65445542
29MP0000778_abnormal_nervous_system1.63613848
30MP0006276_abnormal_autonomic_nervous1.56076442
31MP0001529_abnormal_vocalization1.53179374
32MP0003880_abnormal_central_pattern1.52308972
33MP0002751_abnormal_autonomic_nervous1.52305170
34MP0002254_reproductive_system_inflammat1.50397427
35MP0009703_decreased_birth_body1.49505061
36MP0002084_abnormal_developmental_patter1.46478571
37MP0004197_abnormal_fetal_growth/weight/1.42803702
38MP0001730_embryonic_growth_arrest1.41536723
39MP0000049_abnormal_middle_ear1.38713682
40MP0009672_abnormal_birth_weight1.38394254
41MP0001286_abnormal_eye_development1.36470456
42MP0003861_abnormal_nervous_system1.36303925
43MP0002085_abnormal_embryonic_tissue1.34111696
44MP0001672_abnormal_embryogenesis/_devel1.33762966
45MP0005380_embryogenesis_phenotype1.33762966
46MP0008007_abnormal_cellular_replicative1.27217727
47MP0003221_abnormal_cardiomyocyte_apopto1.25350185
48MP0001177_atelectasis1.23109537
49MP0003646_muscle_fatigue1.16999112
50MP0005423_abnormal_somatic_nervous1.16272702
51MP0008995_early_reproductive_senescence1.12666411
52MP0003984_embryonic_growth_retardation1.12588805
53MP0002736_abnormal_nociception_after1.11669916
54MP0000631_abnormal_neuroendocrine_gland1.11643255
55MP0002088_abnormal_embryonic_growth/wei1.09947944
56MP0002210_abnormal_sex_determination1.08148947
57MP0002234_abnormal_pharynx_morphology1.05672238
58MP0003755_abnormal_palate_morphology1.05303152
59MP0001929_abnormal_gametogenesis1.05002112
60MP0010352_gastrointestinal_tract_polyps1.04816169
61MP0006035_abnormal_mitochondrial_morpho1.03532130
62MP0006072_abnormal_retinal_apoptosis1.02102693
63MP0002697_abnormal_eye_size1.02042637
64MP0002653_abnormal_ependyma_morphology1.01767219
65MP0000516_abnormal_urinary_system0.99240999
66MP0005367_renal/urinary_system_phenotyp0.99240999
67MP0005187_abnormal_penis_morphology0.97543683
68MP0010030_abnormal_orbit_morphology0.96807839
69MP0000350_abnormal_cell_proliferation0.94252896
70MP0001697_abnormal_embryo_size0.94025031
71MP0000955_abnormal_spinal_cord0.94008262
72MP0002152_abnormal_brain_morphology0.92964720
73MP0004270_analgesia0.92664395
74MP0002184_abnormal_innervation0.92644345
75MP0002111_abnormal_tail_morphology0.92430730
76MP0001145_abnormal_male_reproductive0.92327608
77MP0000653_abnormal_sex_gland0.92032625
78MP0000647_abnormal_sebaceous_gland0.89600314
79MP0002080_prenatal_lethality0.88594608
80MP0003935_abnormal_craniofacial_develop0.88044570
81MP0005253_abnormal_eye_physiology0.87392557
82MP0004215_abnormal_myocardial_fiber0.86910028
83MP0002272_abnormal_nervous_system0.84678473
84MP0002081_perinatal_lethality0.84234743
85MP0004859_abnormal_synaptic_plasticity0.83440714
86MP0005248_abnormal_Harderian_gland0.83371757
87MP0005391_vision/eye_phenotype0.83023306
88MP0002752_abnormal_somatic_nervous0.78890328
89MP0005645_abnormal_hypothalamus_physiol0.78618531
90MP0003698_abnormal_male_reproductive0.78588381
91MP0002177_abnormal_outer_ear0.78328865
92MP0001299_abnormal_eye_distance/0.78188926
93MP0004142_abnormal_muscle_tone0.78121534
94MP0003385_abnormal_body_wall0.77114088
95MP0003635_abnormal_synaptic_transmissio0.76579416
96MP0002938_white_spotting0.74585682
97MP0000428_abnormal_craniofacial_morphol0.74458185
98MP0004811_abnormal_neuron_physiology0.73375170
99MP0002092_abnormal_eye_morphology0.70372105
100MP0003137_abnormal_impulse_conducting0.69235063

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.86197161
2Colon cancer (HP:0003003)3.98410798
3Hepatoblastoma (HP:0002884)3.63270779
4Cortical dysplasia (HP:0002539)3.27774669
5Septo-optic dysplasia (HP:0100842)3.11025658
6Supernumerary spleens (HP:0009799)2.91908111
7Abnormal lung lobation (HP:0002101)2.78489613
8Neonatal hypoglycemia (HP:0001998)2.76838046
9Medulloblastoma (HP:0002885)2.74569143
10Papillary thyroid carcinoma (HP:0002895)2.73246331
11Abnormal hair whorl (HP:0010721)2.69163443
12Progressive inability to walk (HP:0002505)2.67303139
13Hyperglycinemia (HP:0002154)2.60650305
14Depressed nasal tip (HP:0000437)2.52611018
15Nephroblastoma (Wilms tumor) (HP:0002667)2.41538942
16Abnormality of the septum pellucidum (HP:0007375)2.41360325
17Embryonal renal neoplasm (HP:0011794)2.37974195
18Pancreatic fibrosis (HP:0100732)2.35224205
19Genital tract atresia (HP:0001827)2.33522245
20Vaginal atresia (HP:0000148)2.23050647
21Neoplasm of the adrenal cortex (HP:0100641)2.22787414
22Volvulus (HP:0002580)2.22202067
23Absent septum pellucidum (HP:0001331)2.18561136
24Gait imbalance (HP:0002141)2.14753914
25Congenital primary aphakia (HP:0007707)2.13484018
26Medial flaring of the eyebrow (HP:0010747)2.13020036
27Abnormal biliary tract physiology (HP:0012439)2.12875979
28Bile duct proliferation (HP:0001408)2.12875979
29Multiple enchondromatosis (HP:0005701)2.12152525
30Abdominal situs inversus (HP:0003363)2.11795415
31Abnormality of abdominal situs (HP:0011620)2.11795415
32Rhabdomyosarcoma (HP:0002859)2.10867020
33Optic nerve hypoplasia (HP:0000609)2.08658051
34Aplasia/Hypoplasia of the sternum (HP:0006714)2.08587671
35Spastic diplegia (HP:0001264)2.07703061
36Pancreatic cysts (HP:0001737)2.07270169
37Birth length less than 3rd percentile (HP:0003561)2.06985089
38Stenosis of the external auditory canal (HP:0000402)2.06448373
39Cupped ear (HP:0000378)2.06429708
40Methylmalonic acidemia (HP:0002912)2.05403313
41Nephrogenic diabetes insipidus (HP:0009806)2.04884416
42Labial hypoplasia (HP:0000066)2.04101510
43Hypoplastic female external genitalia (HP:0012815)2.04067201
44Drooling (HP:0002307)2.03802736
45Gonadotropin excess (HP:0000837)2.00894784
46Chronic hepatic failure (HP:0100626)2.00175196
47Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99689361
48Abnormality of chromosome stability (HP:0003220)1.99099102
49Neoplasm of the oral cavity (HP:0100649)1.95905032
50Broad foot (HP:0001769)1.94910444
51Meckel diverticulum (HP:0002245)1.94695036
52Carpal bone hypoplasia (HP:0001498)1.94670886
53Lip pit (HP:0100267)1.93287710
54Thyroid carcinoma (HP:0002890)1.93279468
55Abnormality of the ileum (HP:0001549)1.89337572
56Failure to thrive in infancy (HP:0001531)1.88425554
57Pancreatic islet-cell hyperplasia (HP:0004510)1.88410080
58Narrow forehead (HP:0000341)1.87631098
59True hermaphroditism (HP:0010459)1.86709695
60Inability to walk (HP:0002540)1.85927731
61Poor coordination (HP:0002370)1.85116770
62Aplasia/Hypoplasia of the uvula (HP:0010293)1.85008135
63Bifid tongue (HP:0010297)1.83936919
64Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83445836
65Micropenis (HP:0000054)1.83290881
66Excessive salivation (HP:0003781)1.83121301
67Intestinal atresia (HP:0011100)1.82039253
68Sloping forehead (HP:0000340)1.79893685
69Molar tooth sign on MRI (HP:0002419)1.79241998
70Abnormality of midbrain morphology (HP:0002418)1.79241998
71Hip dysplasia (HP:0001385)1.78756425
72Abnormality of the metopic suture (HP:0005556)1.78731477
73Anencephaly (HP:0002323)1.78631723
74Aplasia/Hypoplasia of the tibia (HP:0005772)1.78518256
75Abnormality of serine family amino acid metabolism (HP:0010894)1.78136884
76Abnormality of glycine metabolism (HP:0010895)1.78136884
77Scrotal hypoplasia (HP:0000046)1.77457634
78Dandy-Walker malformation (HP:0001305)1.75230576
79Specific learning disability (HP:0001328)1.74430021
80Polyphagia (HP:0002591)1.71736920
81Ependymoma (HP:0002888)1.71511096
82Embryonal neoplasm (HP:0002898)1.71396723
83Glioma (HP:0009733)1.71210462
84Abnormality of the labia (HP:0000058)1.70260059
85Lissencephaly (HP:0001339)1.70194341
86Short tibia (HP:0005736)1.69904862
87Chromsome breakage (HP:0040012)1.69650369
88Abnormality of the columella (HP:0009929)1.69512406
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.67790894
90Oligodactyly (hands) (HP:0001180)1.66272557
91Chorioretinal coloboma (HP:0000567)1.65267667
92Nephronophthisis (HP:0000090)1.64028514
93Preaxial hand polydactyly (HP:0001177)1.63906775
94Agnosia (HP:0010524)1.63636327
95Hyperglycinuria (HP:0003108)1.63345094
96Median cleft lip (HP:0000161)1.62886354
97Abnormality of the clitoris (HP:0000056)1.62798517
98Retinal dysplasia (HP:0007973)1.62297879
99Abnormal pancreas size (HP:0012094)1.60603271
100Shoulder girdle muscle weakness (HP:0003547)1.60180165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.95732155
2MKNK22.76699823
3MAP3K42.67437467
4WNK32.64892434
5MKNK12.59956326
6BCR2.58032950
7TSSK62.52709620
8BRD42.52382783
9SRPK12.30929232
10TTK2.17772379
11NUAK11.96689923
12CDC71.94932688
13TNIK1.92551491
14PLK31.91508294
15ZAK1.90925413
16CDK191.83813471
17CASK1.80629076
18BRSK21.79101948
19PLK41.78457627
20TAF11.77714468
21MAP2K71.72778834
22DYRK31.68847138
23MARK11.65366823
24CSNK1G11.62983725
25ERBB41.58825744
26ERBB31.51460118
27BMPR1B1.48209213
28CSNK1G21.46536330
29MAP4K21.45491757
30ACVR1B1.44487092
31CSNK1G31.42486455
32BUB11.37059672
33DYRK21.35564866
34VRK11.31958521
35PLK11.29695808
36STK38L1.29504513
37TESK11.21540680
38EIF2AK31.19874257
39CSNK1A1L1.13079973
40MAPK131.06015305
41ATR0.98557740
42RPS6KA40.92834304
43CAMK1G0.90678155
44PAK30.90600789
45FRK0.90589300
46MAP3K90.90297926
47SIK30.86132534
48PASK0.82098536
49WEE10.81313204
50PNCK0.81295203
51ATM0.79552619
52STK240.79335576
53SGK20.79309540
54NLK0.79049447
55NTRK20.76190196
56LATS10.75930460
57CHEK10.74427074
58KSR10.73696117
59DYRK1A0.72864191
60MST40.65965102
61CAMK1D0.63739949
62CHEK20.60961886
63SGK2230.60385866
64SGK4940.60385866
65STK30.59758479
66STK160.58260592
67PRKCG0.57491000
68FLT30.57369276
69MINK10.56512384
70BRAF0.56086302
71PBK0.55929955
72PLK20.54548588
73AKT30.54432541
74CSNK1E0.54122970
75MAP2K40.53114225
76ALK0.52710571
77CDK20.52551480
78GRK10.51937783
79NEK10.49443780
80CDK90.48592898
81EIF2AK20.47476903
82STK380.47078337
83CDK120.46003533
84EPHA40.45648395
85CDK10.45146117
86CDK60.45103968
87WNK10.44674523
88BCKDK0.43729270
89PIM10.42315260
90TIE10.41696200
91FGFR10.41250473
92DYRK1B0.40259993
93EPHA30.39914080
94VRK20.39533000
95PINK10.39433731
96AURKB0.38923647
97CSNK1D0.38632689
98UHMK10.37830762
99YES10.37472333
100TGFBR10.37453499

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41321720
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.13699824
3RNA transport_Homo sapiens_hsa030133.12988736
4Basal transcription factors_Homo sapiens_hsa030223.02307995
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.87353476
6RNA degradation_Homo sapiens_hsa030182.74861311
7RNA polymerase_Homo sapiens_hsa030202.73211840
8Steroid biosynthesis_Homo sapiens_hsa001002.61834513
9Mismatch repair_Homo sapiens_hsa034302.54725160
10Non-homologous end-joining_Homo sapiens_hsa034502.46297015
11Spliceosome_Homo sapiens_hsa030402.45358740
12Cell cycle_Homo sapiens_hsa041102.43870863
13mRNA surveillance pathway_Homo sapiens_hsa030152.12029405
14Fanconi anemia pathway_Homo sapiens_hsa034602.07637362
15Nicotine addiction_Homo sapiens_hsa050332.00652123
16Propanoate metabolism_Homo sapiens_hsa006401.95445713
17Protein export_Homo sapiens_hsa030601.90223320
18DNA replication_Homo sapiens_hsa030301.88956510
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74395591
20Homologous recombination_Homo sapiens_hsa034401.73757237
21p53 signaling pathway_Homo sapiens_hsa041151.68790093
22Base excision repair_Homo sapiens_hsa034101.61574247
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53437040
24Oocyte meiosis_Homo sapiens_hsa041141.52473548
25Selenocompound metabolism_Homo sapiens_hsa004501.52136593
26Circadian rhythm_Homo sapiens_hsa047101.49896462
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46055080
28Nucleotide excision repair_Homo sapiens_hsa034201.44411014
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29591366
30Proteasome_Homo sapiens_hsa030501.28291329
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.24294857
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21708181
33Taste transduction_Homo sapiens_hsa047421.19095942
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18276922
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17860252
36One carbon pool by folate_Homo sapiens_hsa006701.16580739
37Wnt signaling pathway_Homo sapiens_hsa043101.14576965
38Colorectal cancer_Homo sapiens_hsa052101.07654010
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05289119
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03384795
41Hippo signaling pathway_Homo sapiens_hsa043901.01879728
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97886461
43Phototransduction_Homo sapiens_hsa047440.95521728
44Regulation of autophagy_Homo sapiens_hsa041400.95157033
45Basal cell carcinoma_Homo sapiens_hsa052170.94803254
46Butanoate metabolism_Homo sapiens_hsa006500.89559741
47TGF-beta signaling pathway_Homo sapiens_hsa043500.86493934
48Hedgehog signaling pathway_Homo sapiens_hsa043400.85222946
49Purine metabolism_Homo sapiens_hsa002300.85187106
50Pyrimidine metabolism_Homo sapiens_hsa002400.78945472
51Adherens junction_Homo sapiens_hsa045200.78913500
52Long-term depression_Homo sapiens_hsa047300.77049817
53Fatty acid elongation_Homo sapiens_hsa000620.76695840
54GABAergic synapse_Homo sapiens_hsa047270.73747942
55Lysine degradation_Homo sapiens_hsa003100.68485705
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66368198
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63874073
58MicroRNAs in cancer_Homo sapiens_hsa052060.63227143
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61512217
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59325540
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58892729
62Olfactory transduction_Homo sapiens_hsa047400.56212567
63Axon guidance_Homo sapiens_hsa043600.55621806
64FoxO signaling pathway_Homo sapiens_hsa040680.53788930
65Ether lipid metabolism_Homo sapiens_hsa005650.53722325
66Epstein-Barr virus infection_Homo sapiens_hsa051690.53226027
67Huntingtons disease_Homo sapiens_hsa050160.50367814
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50029049
69Peroxisome_Homo sapiens_hsa041460.47672232
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44316201
71Dopaminergic synapse_Homo sapiens_hsa047280.43469158
72Dorso-ventral axis formation_Homo sapiens_hsa043200.43038249
73Fatty acid metabolism_Homo sapiens_hsa012120.42350643
74Serotonergic synapse_Homo sapiens_hsa047260.42304000
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41982278
76Melanoma_Homo sapiens_hsa052180.41027237
77Viral carcinogenesis_Homo sapiens_hsa052030.39521978
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39148820
79Nitrogen metabolism_Homo sapiens_hsa009100.37747592
80beta-Alanine metabolism_Homo sapiens_hsa004100.36867111
81Glutamatergic synapse_Homo sapiens_hsa047240.36523029
82Thyroid cancer_Homo sapiens_hsa052160.36236399
83Alcoholism_Homo sapiens_hsa050340.36156401
84Amphetamine addiction_Homo sapiens_hsa050310.35848251
85Pyruvate metabolism_Homo sapiens_hsa006200.34446840
86Prostate cancer_Homo sapiens_hsa052150.33267118
87Gap junction_Homo sapiens_hsa045400.31280427
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30364391
89Tight junction_Homo sapiens_hsa045300.30096279
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28770280
91Circadian entrainment_Homo sapiens_hsa047130.26463988
92Morphine addiction_Homo sapiens_hsa050320.25155448
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24514630
94Endometrial cancer_Homo sapiens_hsa052130.24039339
95Biosynthesis of amino acids_Homo sapiens_hsa012300.23471627
96Parkinsons disease_Homo sapiens_hsa050120.23398389
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23135890
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22217747
99Cardiac muscle contraction_Homo sapiens_hsa042600.21390134
100Melanogenesis_Homo sapiens_hsa049160.21268068

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