ZNF135

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)5.82883606
2behavioral response to nicotine (GO:0035095)5.23476042
3response to pheromone (GO:0019236)4.88843433
4piRNA metabolic process (GO:0034587)3.91114926
5centriole assembly (GO:0098534)3.85447689
6pyrimidine nucleobase catabolic process (GO:0006208)3.85379273
7protoporphyrinogen IX biosynthetic process (GO:0006782)3.75407687
8epithelial cilium movement (GO:0003351)3.66556672
9N-acetylglucosamine metabolic process (GO:0006044)3.66314719
10N-acetylneuraminate metabolic process (GO:0006054)3.63213555
11replication fork processing (GO:0031297)3.57712141
12regulation of cilium movement (GO:0003352)3.55922912
13intraciliary transport (GO:0042073)3.47338351
14male meiosis (GO:0007140)3.43934609
15G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.42122987
16presynaptic membrane assembly (GO:0097105)3.35124725
17reciprocal meiotic recombination (GO:0007131)3.34795933
18reciprocal DNA recombination (GO:0035825)3.34795933
19regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.31943372
20protein localization to cilium (GO:0061512)3.31424555
21limb bud formation (GO:0060174)3.29435299
22nucleobase catabolic process (GO:0046113)3.27861111
23thalamus development (GO:0021794)3.26772469
24male meiosis I (GO:0007141)3.22905984
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.18048928
26somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15298147
27somatic hypermutation of immunoglobulin genes (GO:0016446)3.15298147
28gamma-aminobutyric acid transport (GO:0015812)3.13282199
29postsynaptic membrane organization (GO:0001941)3.11027508
30positive regulation of histone deacetylation (GO:0031065)3.08580035
31behavioral response to ethanol (GO:0048149)3.06793376
32regulation of MHC class II biosynthetic process (GO:0045346)3.04105491
33synaptic transmission, cholinergic (GO:0007271)2.99451021
34protein polyglutamylation (GO:0018095)2.95093927
35neuronal action potential (GO:0019228)2.93952947
36regulation of hexokinase activity (GO:1903299)2.92830568
37regulation of glucokinase activity (GO:0033131)2.92830568
38cellular ketone body metabolic process (GO:0046950)2.92113579
39presynaptic membrane organization (GO:0097090)2.88504552
40cilium movement (GO:0003341)2.88388340
41platelet dense granule organization (GO:0060155)2.88278834
42regulation of meiosis I (GO:0060631)2.86781490
43negative regulation of cytosolic calcium ion concentration (GO:0051481)2.84922326
44synapsis (GO:0007129)2.84010351
45regulation of action potential (GO:0098900)2.82988859
46neural tube formation (GO:0001841)2.82484950
47regulation of synapse structural plasticity (GO:0051823)2.76196576
48mechanosensory behavior (GO:0007638)2.74383530
49response to misfolded protein (GO:0051788)2.68863155
50neuron cell-cell adhesion (GO:0007158)2.66055274
51DNA methylation involved in gamete generation (GO:0043046)2.65020760
52cilium morphogenesis (GO:0060271)2.64897129
53kidney morphogenesis (GO:0060993)2.64036853
54ventricular system development (GO:0021591)2.63162561
55positive regulation of histone H3-K4 methylation (GO:0051571)2.62095321
56regulation of microtubule-based movement (GO:0060632)2.58749043
57ketone body metabolic process (GO:1902224)2.57034644
58cardiac left ventricle morphogenesis (GO:0003214)2.56798546
59proline transport (GO:0015824)2.56108499
60nonmotile primary cilium assembly (GO:0035058)2.56042153
61limb development (GO:0060173)2.55565920
62appendage development (GO:0048736)2.55565920
63somite rostral/caudal axis specification (GO:0032525)2.55241519
64regulation of neurotransmitter uptake (GO:0051580)2.54832892
65auditory behavior (GO:0031223)2.54026565
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51676398
67cornea development in camera-type eye (GO:0061303)2.49671585
68detection of light stimulus involved in sensory perception (GO:0050962)2.49440727
69detection of light stimulus involved in visual perception (GO:0050908)2.49440727
70histone H2A acetylation (GO:0043968)2.48388806
71cilium organization (GO:0044782)2.48158869
72regulation of telomere maintenance (GO:0032204)2.47800144
73glutathione biosynthetic process (GO:0006750)2.47742684
74positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.46795844
75cilium assembly (GO:0042384)2.45913744
76base-excision repair, AP site formation (GO:0006285)2.45088593
77inositol phosphate catabolic process (GO:0071545)2.44882124
78phosphatidylethanolamine metabolic process (GO:0046337)2.44844836
79magnesium ion transport (GO:0015693)2.43326305
80meiosis I (GO:0007127)2.43311635
81nonribosomal peptide biosynthetic process (GO:0019184)2.41244965
82retinal cone cell development (GO:0046549)2.40693808
83axoneme assembly (GO:0035082)2.40335708
84regulation of nuclear cell cycle DNA replication (GO:0033262)2.38200255
85prostate gland growth (GO:0060736)2.37208611
86polyol catabolic process (GO:0046174)2.36492158
87protoporphyrinogen IX metabolic process (GO:0046501)2.35943481
88regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.35671776
89regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.35671776
90olfactory bulb development (GO:0021772)2.35614152
91glycerophospholipid catabolic process (GO:0046475)2.35287205
92glucosamine-containing compound metabolic process (GO:1901071)2.34508481
93dopamine transport (GO:0015872)2.33957524
94DNA double-strand break processing (GO:0000729)2.33101001
95adaptation of signaling pathway (GO:0023058)2.31951510
96positive regulation of meiosis (GO:0045836)2.31473392
97L-fucose metabolic process (GO:0042354)2.31085226
98L-fucose catabolic process (GO:0042355)2.31085226
99fucose catabolic process (GO:0019317)2.31085226
100protein neddylation (GO:0045116)2.31025561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.88961911
2EZH2_22144423_ChIP-Seq_EOC_Human3.80603141
3ZNF274_21170338_ChIP-Seq_K562_Hela3.57167737
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.34207088
5IGF1R_20145208_ChIP-Seq_DFB_Human3.23439410
6GBX2_23144817_ChIP-Seq_PC3_Human3.17876764
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.89872074
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.73298481
9VDR_22108803_ChIP-Seq_LS180_Human2.64425316
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.42137705
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20301714
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.18000067
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10516453
14FUS_26573619_Chip-Seq_HEK293_Human2.09091142
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04859117
16P300_19829295_ChIP-Seq_ESCs_Human2.01011257
17ER_23166858_ChIP-Seq_MCF-7_Human1.92452788
18BCAT_22108803_ChIP-Seq_LS180_Human1.83678992
19TAF15_26573619_Chip-Seq_HEK293_Human1.81191370
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79166514
21EWS_26573619_Chip-Seq_HEK293_Human1.79127902
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76186116
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75581282
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.75142709
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73644026
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72480723
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67748436
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66572950
29STAT3_23295773_ChIP-Seq_U87_Human1.63571032
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62129826
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61748083
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61748083
33SMAD4_21799915_ChIP-Seq_A2780_Human1.60930181
34TCF4_23295773_ChIP-Seq_U87_Human1.58968601
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55935536
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55081623
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54928255
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.53077154
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.51366835
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49396462
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47912309
42IRF1_19129219_ChIP-ChIP_H3396_Human1.46919842
43AR_25329375_ChIP-Seq_VCAP_Human1.45239664
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45173253
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44749701
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43151761
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42255445
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42240422
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41920630
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39909329
51REST_21632747_ChIP-Seq_MESCs_Mouse1.39544789
52RNF2_27304074_Chip-Seq_NSC_Mouse1.39017902
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34475367
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33630088
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33563788
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32979005
57CBP_20019798_ChIP-Seq_JUKART_Human1.29000910
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29000910
59TCF4_22108803_ChIP-Seq_LS180_Human1.25138252
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24729172
61RUNX2_22187159_ChIP-Seq_PCA_Human1.23820921
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.23248678
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21624051
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21407170
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.16705816
66TP53_22573176_ChIP-Seq_HFKS_Human1.16622092
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15321827
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14984957
69NCOR_22424771_ChIP-Seq_293T_Human1.14775807
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14360187
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.13787714
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13055267
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.12734178
74* NANOG_19829295_ChIP-Seq_ESCs_Human1.12173280
75* SOX2_19829295_ChIP-Seq_ESCs_Human1.12173280
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11909446
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10561839
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08649362
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.07612182
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06960767
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.06960767
82P53_22387025_ChIP-Seq_ESCs_Mouse1.06956299
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03610749
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03568594
85MYC_18940864_ChIP-ChIP_HL60_Human1.02512760
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.01135036
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.00506984
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00161022
89SOX2_21211035_ChIP-Seq_LN229_Gbm0.99678397
90HOXB7_26014856_ChIP-Seq_BT474_Human0.99044215
91SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97828344
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.95493613
93EZH2_27304074_Chip-Seq_ESCs_Mouse0.95440413
94REST_18959480_ChIP-ChIP_MESCs_Mouse0.94700505
95KDM2B_26808549_Chip-Seq_REH_Human0.94285787
96CMYC_18555785_Chip-Seq_ESCs_Mouse0.93513549
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.91847108
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91792817
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90186152
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89470767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.81616831
2MP0008877_abnormal_DNA_methylation3.09715232
3MP0005083_abnormal_biliary_tract3.09175738
4MP0008058_abnormal_DNA_repair2.60874145
5MP0004043_abnormal_pH_regulation2.53565306
6MP0003880_abnormal_central_pattern2.48760542
7MP0001529_abnormal_vocalization2.34529596
8MP0004885_abnormal_endolymph2.32857866
9MP0004147_increased_porphyrin_level2.27845561
10MP0005551_abnormal_eye_electrophysiolog2.07788301
11MP0005646_abnormal_pituitary_gland2.03697437
12MP0002837_dystrophic_cardiac_calcinosis2.02389495
13MP0003787_abnormal_imprinting1.95442198
14MP0001968_abnormal_touch/_nociception1.84554032
15MP0005645_abnormal_hypothalamus_physiol1.78318451
16MP0008995_early_reproductive_senescence1.77509997
17MP0003121_genomic_imprinting1.75795943
18MP0004133_heterotaxia1.74648720
19MP0000631_abnormal_neuroendocrine_gland1.72612135
20MP0008961_abnormal_basal_metabolism1.64717673
21MP0001486_abnormal_startle_reflex1.63652711
22MP0002736_abnormal_nociception_after1.61932360
23MP0002272_abnormal_nervous_system1.60694252
24MP0009745_abnormal_behavioral_response1.60610570
25MP0005365_abnormal_bile_salt1.56759167
26MP0006292_abnormal_olfactory_placode1.56149851
27MP0001501_abnormal_sleep_pattern1.54665437
28MP0003011_delayed_dark_adaptation1.52908149
29MP0000516_abnormal_urinary_system1.52013678
30MP0005367_renal/urinary_system_phenotyp1.52013678
31MP0002638_abnormal_pupillary_reflex1.51763844
32MP0003252_abnormal_bile_duct1.50383877
33MP0009046_muscle_twitch1.50293465
34MP0002909_abnormal_adrenal_gland1.43848361
35MP0006072_abnormal_retinal_apoptosis1.43347453
36MP0000778_abnormal_nervous_system1.40966016
37MP0002572_abnormal_emotion/affect_behav1.40676343
38MP0004742_abnormal_vestibular_system1.39633184
39MP0002822_catalepsy1.39415975
40MP0008057_abnormal_DNA_replication1.38606452
41MP0004142_abnormal_muscle_tone1.38434828
42MP0002735_abnormal_chemical_nociception1.38398149
43MP0008872_abnormal_physiological_respon1.36010104
44MP0008789_abnormal_olfactory_epithelium1.35905024
45MP0002557_abnormal_social/conspecific_i1.34249738
46MP0002938_white_spotting1.30902437
47MP0005085_abnormal_gallbladder_physiolo1.30650737
48MP0005253_abnormal_eye_physiology1.29767670
49MP0002163_abnormal_gland_morphology1.29767328
50MP0002751_abnormal_autonomic_nervous1.28744376
51MP0002102_abnormal_ear_morphology1.28178853
52MP0002876_abnormal_thyroid_physiology1.25664292
53MP0006276_abnormal_autonomic_nervous1.23009170
54MP0005423_abnormal_somatic_nervous1.22318129
55MP0003635_abnormal_synaptic_transmissio1.22096713
56MP0002063_abnormal_learning/memory/cond1.20132616
57MP0002064_seizures1.19198761
58MP0002734_abnormal_mechanical_nocicepti1.18069473
59MP0001984_abnormal_olfaction1.17804601
60MP0000569_abnormal_digit_pigmentation1.16628973
61MP0002234_abnormal_pharynx_morphology1.15960823
62MP0001905_abnormal_dopamine_level1.15174163
63MP0005394_taste/olfaction_phenotype1.14297310
64MP0005499_abnormal_olfactory_system1.14297310
65MP0002653_abnormal_ependyma_morphology1.13424307
66MP0005379_endocrine/exocrine_gland_phen1.12429749
67MP0003698_abnormal_male_reproductive1.11940142
68MP0002067_abnormal_sensory_capabilities1.11577610
69MP0005386_behavior/neurological_phenoty1.11548275
70MP0004924_abnormal_behavior1.11548275
71MP0002210_abnormal_sex_determination1.11418363
72MP0003122_maternal_imprinting1.11279999
73MP0001929_abnormal_gametogenesis1.05569934
74MP0004270_analgesia1.03307255
75MP0010329_abnormal_lipoprotein_level1.00931577
76MP0001970_abnormal_pain_threshold0.99489721
77MP0002733_abnormal_thermal_nociception0.98823800
78MP0005670_abnormal_white_adipose0.96189097
79MP0001986_abnormal_taste_sensitivity0.94971184
80MP0000955_abnormal_spinal_cord0.94598610
81MP0003786_premature_aging0.92766293
82MP0001502_abnormal_circadian_rhythm0.90399461
83MP0010386_abnormal_urinary_bladder0.90399258
84MP0008775_abnormal_heart_ventricle0.90209700
85MP0002184_abnormal_innervation0.90163975
86MP0000427_abnormal_hair_cycle0.88415284
87MP0000653_abnormal_sex_gland0.88209042
88MP0002882_abnormal_neuron_morphology0.87554767
89MP0005174_abnormal_tail_pigmentation0.85881898
90MP0001145_abnormal_male_reproductive0.85077050
91MP0001485_abnormal_pinna_reflex0.83458975
92MP0003123_paternal_imprinting0.81960401
93MP0002229_neurodegeneration0.81257196
94MP0005084_abnormal_gallbladder_morpholo0.81108947
95MP0002752_abnormal_somatic_nervous0.80791644
96MP0002277_abnormal_respiratory_mucosa0.79175396
97MP0001324_abnormal_eye_pigmentation0.78917993
98MP0002069_abnormal_eating/drinking_beha0.78889710
99MP0000026_abnormal_inner_ear0.78381306
100MP0005075_abnormal_melanosome_morpholog0.76995750

Predicted human phenotypes

RankGene SetZ-score
1Nephronophthisis (HP:0000090)3.85958852
2Pancreatic fibrosis (HP:0100732)3.65552912
3True hermaphroditism (HP:0010459)3.65416743
4Abnormality of the renal medulla (HP:0100957)3.58182011
5Pancreatic cysts (HP:0001737)3.53115255
6Abnormality of the renal cortex (HP:0011035)3.51421354
7Hyperventilation (HP:0002883)3.48781317
8Medial flaring of the eyebrow (HP:0010747)3.40027853
9Molar tooth sign on MRI (HP:0002419)3.37638664
10Abnormality of midbrain morphology (HP:0002418)3.37638664
11Gait imbalance (HP:0002141)2.83220979
12Intestinal atresia (HP:0011100)2.82682154
13Aplasia/Hypoplasia of the uvula (HP:0010293)2.76717159
14Tubulointerstitial nephritis (HP:0001970)2.72327461
15Cystic liver disease (HP:0006706)2.66872078
16Absent speech (HP:0001344)2.66104040
17Gaze-evoked nystagmus (HP:0000640)2.65154997
18Tubular atrophy (HP:0000092)2.64454418
19Congenital primary aphakia (HP:0007707)2.62804345
20Congenital stationary night blindness (HP:0007642)2.60925995
21Genital tract atresia (HP:0001827)2.57461744
22Broad-based gait (HP:0002136)2.53068092
23Protruding tongue (HP:0010808)2.49024975
24Tubulointerstitial abnormality (HP:0001969)2.45884491
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.44807871
26Absent/shortened dynein arms (HP:0200106)2.44807871
27Renal cortical cysts (HP:0000803)2.40901515
28Meckel diverticulum (HP:0002245)2.40813622
29Progressive cerebellar ataxia (HP:0002073)2.40057989
30Pachygyria (HP:0001302)2.38933110
31Vaginal atresia (HP:0000148)2.38140580
32Nephrogenic diabetes insipidus (HP:0009806)2.36885603
33Abnormality of vitamin B metabolism (HP:0004340)2.36738956
34Poor coordination (HP:0002370)2.36247461
35Abnormal hair whorl (HP:0010721)2.35965034
36Anencephaly (HP:0002323)2.35820478
37Abnormality of the ileum (HP:0001549)2.32972240
38Postaxial foot polydactyly (HP:0001830)2.32878961
39Inability to walk (HP:0002540)2.32383694
40Congenital hepatic fibrosis (HP:0002612)2.30590267
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.29532408
42Volvulus (HP:0002580)2.28604933
43Acute necrotizing encephalopathy (HP:0006965)2.23404705
44Azoospermia (HP:0000027)2.21297903
45Attenuation of retinal blood vessels (HP:0007843)2.20218894
46Progressive inability to walk (HP:0002505)2.19140413
47Chronic hepatic failure (HP:0100626)2.18821918
48Methylmalonic acidemia (HP:0002912)2.17034968
49Drooling (HP:0002307)2.15341619
50Fair hair (HP:0002286)2.14990094
51Pendular nystagmus (HP:0012043)2.13735106
52Sclerocornea (HP:0000647)2.10458012
53Astigmatism (HP:0000483)2.08122225
54Tubulointerstitial fibrosis (HP:0005576)2.05586909
55Type II lissencephaly (HP:0007260)2.04112229
56Colon cancer (HP:0003003)2.04110793
57Polyuria (HP:0000103)2.03805671
58Abnormality of the vitamin B12 metabolism (HP:0004341)2.03035272
59Abolished electroretinogram (ERG) (HP:0000550)2.02891068
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02369398
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.02369398
62Hypothermia (HP:0002045)2.02239604
63Postaxial hand polydactyly (HP:0001162)2.00932847
64Lissencephaly (HP:0001339)2.00061187
65Hyperglycinemia (HP:0002154)1.98823973
66Widely spaced teeth (HP:0000687)1.98666021
67Abnormal rod and cone electroretinograms (HP:0008323)1.98470758
68Clubbing of toes (HP:0100760)1.94522140
69Polydipsia (HP:0001959)1.94488341
70Abnormal drinking behavior (HP:0030082)1.94488341
71Progressive macrocephaly (HP:0004481)1.94437513
72Abnormal respiratory epithelium morphology (HP:0012253)1.94092399
73Abnormal respiratory motile cilium morphology (HP:0005938)1.94092399
74Excessive salivation (HP:0003781)1.91523636
75Abnormality of the labia minora (HP:0012880)1.90709393
76Abnormality of chromosome stability (HP:0003220)1.89833539
77Keratoconus (HP:0000563)1.89001981
78Increased corneal curvature (HP:0100692)1.89001981
79Focal motor seizures (HP:0011153)1.87756504
80Male pseudohermaphroditism (HP:0000037)1.87311097
81Optic nerve hypoplasia (HP:0000609)1.86426601
82Abnormality of the preputium (HP:0100587)1.85918667
83Thyroid-stimulating hormone excess (HP:0002925)1.81994855
84Acute encephalopathy (HP:0006846)1.81920077
85Abnormal ciliary motility (HP:0012262)1.81639687
86Neoplasm of the adrenal cortex (HP:0100641)1.81639340
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.81002673
88Abnormality of the corticospinal tract (HP:0002492)1.80623572
89Febrile seizures (HP:0002373)1.79788880
90Mitochondrial inheritance (HP:0001427)1.79477599
91Increased hepatocellular lipid droplets (HP:0006565)1.78417679
92Gonadotropin excess (HP:0000837)1.77592138
93Abnormality of vitamin metabolism (HP:0100508)1.76810570
94Polyphagia (HP:0002591)1.76721494
95Testicular atrophy (HP:0000029)1.74623596
96Abnormal mitochondria in muscle tissue (HP:0008316)1.74252226
97Limb dystonia (HP:0002451)1.70432147
98Supernumerary spleens (HP:0009799)1.69590783
99Stage 5 chronic kidney disease (HP:0003774)1.68279648
100Bony spicule pigmentary retinopathy (HP:0007737)1.68147656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB14.24337903
2NEK23.87307404
3FRK3.70564105
4WNK33.37509023
5MAP4K23.02930538
6NUAK12.84820863
7CAMKK22.62667594
8CAMK1D2.51545743
9CASK2.47440783
10PINK12.41102259
11GRK12.22501769
12TAF12.19891092
13CAMK1G2.19867327
14MAPK132.15306742
15MARK12.12075076
16VRK21.98691084
17NTRK31.91613886
18INSRR1.88482680
19ADRBK21.61827300
20WNK41.57724528
21EPHA41.49336054
22BMPR1B1.47616407
23MAP3K41.46649557
24PNCK1.45870199
25MKNK21.34718977
26DYRK21.33892604
27TNIK1.32427392
28ZAK1.29184698
29LATS11.27149875
30VRK11.24798074
31PAK31.23066189
32CSNK1G21.18583590
33CAMK11.17458557
34EPHA31.12549890
35CSNK1G11.12288625
36CSNK1G31.02421088
37BCR1.01748926
38OXSR11.00599454
39ACVR1B1.00483285
40MAP3K70.99959580
41NEK10.96180138
42PRKCE0.93128086
43STK390.92564091
44TNK20.90994829
45PRKCG0.90196491
46PLK40.89571138
47DAPK20.88186469
48PLK20.83406578
49TSSK60.81721654
50PHKG20.81115470
51PHKG10.81115470
52MAPKAPK50.80804341
53PLK30.73494866
54PKN10.71023560
55STK30.68528127
56NTRK20.66119569
57CHUK0.64650977
58MKNK10.64383426
59BRSK20.64202961
60EPHB20.63601655
61MAP2K70.62981363
62TRIM280.60838437
63ADRBK10.59542391
64SIK20.59107946
65CAMKK10.58162512
66FGFR20.56067273
67MINK10.55741330
68CAMK40.55053065
69PRKG10.54909619
70CSNK1A10.53594899
71SGK20.52846899
72TIE10.52054075
73STK38L0.51473558
74STK110.50171631
75PTK2B0.45378387
76TYRO30.44514151
77GRK50.44327521
78CSNK1A1L0.42532119
79IRAK10.42266204
80DYRK1A0.41068070
81CSNK1E0.39272858
82CAMK2A0.38638546
83ATM0.38571029
84PRKAA20.37039299
85EIF2AK20.36863523
86MAPK150.36611402
87CDK50.35805959
88SGK4940.34423572
89SGK2230.34423572
90TLK10.34340888
91WNK10.32770651
92PRKAA10.32641750
93PRKACA0.32298378
94UHMK10.31932388
95DYRK30.31514528
96KIT0.31081931
97CSNK1D0.30735353
98FER0.30257540
99FLT30.29581752
100PRKACB0.29524238

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.06813878
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.94234752
3Selenocompound metabolism_Homo sapiens_hsa004502.86829655
4Butanoate metabolism_Homo sapiens_hsa006502.54351249
5Fanconi anemia pathway_Homo sapiens_hsa034602.49883447
6Nicotine addiction_Homo sapiens_hsa050332.49228522
7Phototransduction_Homo sapiens_hsa047442.35028178
8Propanoate metabolism_Homo sapiens_hsa006402.33181768
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10183830
10Basal transcription factors_Homo sapiens_hsa030221.96461777
11Linoleic acid metabolism_Homo sapiens_hsa005911.92514655
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88207219
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83233138
14Caffeine metabolism_Homo sapiens_hsa002321.81552717
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.79441152
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76506276
17Homologous recombination_Homo sapiens_hsa034401.76245614
18Oxidative phosphorylation_Homo sapiens_hsa001901.72529699
19Ether lipid metabolism_Homo sapiens_hsa005651.64142332
20Insulin secretion_Homo sapiens_hsa049111.51956904
21Nitrogen metabolism_Homo sapiens_hsa009101.47261659
22Tryptophan metabolism_Homo sapiens_hsa003801.46089636
23Parkinsons disease_Homo sapiens_hsa050121.45916265
24beta-Alanine metabolism_Homo sapiens_hsa004101.43126690
25Protein export_Homo sapiens_hsa030601.42549587
26Taste transduction_Homo sapiens_hsa047421.26457592
27Glutamatergic synapse_Homo sapiens_hsa047241.24712613
28Cocaine addiction_Homo sapiens_hsa050301.24374776
29Folate biosynthesis_Homo sapiens_hsa007901.18604922
30Regulation of autophagy_Homo sapiens_hsa041401.16688165
31GABAergic synapse_Homo sapiens_hsa047271.16090505
32Fatty acid elongation_Homo sapiens_hsa000621.14693831
33Circadian entrainment_Homo sapiens_hsa047131.13608423
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12740921
35Peroxisome_Homo sapiens_hsa041461.12227127
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09040879
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08100034
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06969704
39Morphine addiction_Homo sapiens_hsa050321.06725208
40One carbon pool by folate_Homo sapiens_hsa006701.03946146
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03330705
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.03148137
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01614572
44Serotonergic synapse_Homo sapiens_hsa047261.00849672
45Lysine degradation_Homo sapiens_hsa003101.00825436
46Retinol metabolism_Homo sapiens_hsa008301.00614293
47Olfactory transduction_Homo sapiens_hsa047400.97140150
48Ovarian steroidogenesis_Homo sapiens_hsa049130.96654827
49Synaptic vesicle cycle_Homo sapiens_hsa047210.96240944
50Non-homologous end-joining_Homo sapiens_hsa034500.95666872
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93176534
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.92353974
53Dopaminergic synapse_Homo sapiens_hsa047280.92276596
54Amphetamine addiction_Homo sapiens_hsa050310.92247791
55Cardiac muscle contraction_Homo sapiens_hsa042600.87124821
56ABC transporters_Homo sapiens_hsa020100.86346677
57Huntingtons disease_Homo sapiens_hsa050160.85808533
58Hedgehog signaling pathway_Homo sapiens_hsa043400.85768562
59Glycerolipid metabolism_Homo sapiens_hsa005610.84786498
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84714029
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84224806
62Fatty acid degradation_Homo sapiens_hsa000710.83408614
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83038122
64Mismatch repair_Homo sapiens_hsa034300.80721133
65Axon guidance_Homo sapiens_hsa043600.78330616
66Chemical carcinogenesis_Homo sapiens_hsa052040.76751795
67Histidine metabolism_Homo sapiens_hsa003400.75439344
68RNA polymerase_Homo sapiens_hsa030200.75260112
69Calcium signaling pathway_Homo sapiens_hsa040200.73674991
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.72605861
71Arachidonic acid metabolism_Homo sapiens_hsa005900.71497856
72Base excision repair_Homo sapiens_hsa034100.70739201
73RNA degradation_Homo sapiens_hsa030180.68001726
74Renin-angiotensin system_Homo sapiens_hsa046140.66360273
75cAMP signaling pathway_Homo sapiens_hsa040240.66023960
76Salivary secretion_Homo sapiens_hsa049700.65438068
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63319126
78Circadian rhythm_Homo sapiens_hsa047100.63279041
79Alzheimers disease_Homo sapiens_hsa050100.62395058
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59272373
81Dorso-ventral axis formation_Homo sapiens_hsa043200.58016084
82Long-term depression_Homo sapiens_hsa047300.57942840
83Metabolic pathways_Homo sapiens_hsa011000.53986028
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.50384341
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50304051
86Basal cell carcinoma_Homo sapiens_hsa052170.50280976
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49251061
88Cholinergic synapse_Homo sapiens_hsa047250.47560372
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46573882
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46544874
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.45980997
92Nucleotide excision repair_Homo sapiens_hsa034200.44654636
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43597067
94Oocyte meiosis_Homo sapiens_hsa041140.42786616
95Collecting duct acid secretion_Homo sapiens_hsa049660.42764986
96Sulfur metabolism_Homo sapiens_hsa009200.42757289
97Fatty acid metabolism_Homo sapiens_hsa012120.42409097
98Renin secretion_Homo sapiens_hsa049240.42075204
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40668755
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40351730

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