ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	centriole replication (GO:0007099)	5.82883606
2	behavioral response to nicotine (GO:0035095)	5.23476042
3	response to pheromone (GO:0019236)	4.88843433
4	piRNA metabolic process (GO:0034587)	3.91114926
5	centriole assembly (GO:0098534)	3.85447689
6	pyrimidine nucleobase catabolic process (GO:0006208)	3.85379273
7	protoporphyrinogen IX biosynthetic process (GO:0006782)	3.75407687
8	epithelial cilium movement (GO:0003351)	3.66556672
9	N-acetylglucosamine metabolic process (GO:0006044)	3.66314719
10	N-acetylneuraminate metabolic process (GO:0006054)	3.63213555
11	replication fork processing (GO:0031297)	3.57712141
12	regulation of cilium movement (GO:0003352)	3.55922912
13	intraciliary transport (GO:0042073)	3.47338351
14	male meiosis (GO:0007140)	3.43934609
15	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.42122987
16	presynaptic membrane assembly (GO:0097105)	3.35124725
17	reciprocal meiotic recombination (GO:0007131)	3.34795933
18	reciprocal DNA recombination (GO:0035825)	3.34795933
19	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.31943372
20	protein localization to cilium (GO:0061512)	3.31424555
21	limb bud formation (GO:0060174)	3.29435299
22	nucleobase catabolic process (GO:0046113)	3.27861111
23	thalamus development (GO:0021794)	3.26772469
24	male meiosis I (GO:0007141)	3.22905984
25	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.18048928
26	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.15298147
27	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.15298147
28	gamma-aminobutyric acid transport (GO:0015812)	3.13282199
29	postsynaptic membrane organization (GO:0001941)	3.11027508
30	positive regulation of histone deacetylation (GO:0031065)	3.08580035
31	behavioral response to ethanol (GO:0048149)	3.06793376
32	regulation of MHC class II biosynthetic process (GO:0045346)	3.04105491
33	synaptic transmission, cholinergic (GO:0007271)	2.99451021
34	protein polyglutamylation (GO:0018095)	2.95093927
35	neuronal action potential (GO:0019228)	2.93952947
36	regulation of hexokinase activity (GO:1903299)	2.92830568
37	regulation of glucokinase activity (GO:0033131)	2.92830568
38	cellular ketone body metabolic process (GO:0046950)	2.92113579
39	presynaptic membrane organization (GO:0097090)	2.88504552
40	cilium movement (GO:0003341)	2.88388340
41	platelet dense granule organization (GO:0060155)	2.88278834
42	regulation of meiosis I (GO:0060631)	2.86781490
43	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.84922326
44	synapsis (GO:0007129)	2.84010351
45	regulation of action potential (GO:0098900)	2.82988859
46	neural tube formation (GO:0001841)	2.82484950
47	regulation of synapse structural plasticity (GO:0051823)	2.76196576
48	mechanosensory behavior (GO:0007638)	2.74383530
49	response to misfolded protein (GO:0051788)	2.68863155
50	neuron cell-cell adhesion (GO:0007158)	2.66055274
51	DNA methylation involved in gamete generation (GO:0043046)	2.65020760
52	cilium morphogenesis (GO:0060271)	2.64897129
53	kidney morphogenesis (GO:0060993)	2.64036853
54	ventricular system development (GO:0021591)	2.63162561
55	positive regulation of histone H3-K4 methylation (GO:0051571)	2.62095321
56	regulation of microtubule-based movement (GO:0060632)	2.58749043
57	ketone body metabolic process (GO:1902224)	2.57034644
58	cardiac left ventricle morphogenesis (GO:0003214)	2.56798546
59	proline transport (GO:0015824)	2.56108499
60	nonmotile primary cilium assembly (GO:0035058)	2.56042153
61	limb development (GO:0060173)	2.55565920
62	appendage development (GO:0048736)	2.55565920
63	somite rostral/caudal axis specification (GO:0032525)	2.55241519
64	regulation of neurotransmitter uptake (GO:0051580)	2.54832892
65	auditory behavior (GO:0031223)	2.54026565
66	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.51676398
67	cornea development in camera-type eye (GO:0061303)	2.49671585
68	detection of light stimulus involved in sensory perception (GO:0050962)	2.49440727
69	detection of light stimulus involved in visual perception (GO:0050908)	2.49440727
70	histone H2A acetylation (GO:0043968)	2.48388806
71	cilium organization (GO:0044782)	2.48158869
72	regulation of telomere maintenance (GO:0032204)	2.47800144
73	glutathione biosynthetic process (GO:0006750)	2.47742684
74	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.46795844
75	cilium assembly (GO:0042384)	2.45913744
76	base-excision repair, AP site formation (GO:0006285)	2.45088593
77	inositol phosphate catabolic process (GO:0071545)	2.44882124
78	phosphatidylethanolamine metabolic process (GO:0046337)	2.44844836
79	magnesium ion transport (GO:0015693)	2.43326305
80	meiosis I (GO:0007127)	2.43311635
81	nonribosomal peptide biosynthetic process (GO:0019184)	2.41244965
82	retinal cone cell development (GO:0046549)	2.40693808
83	axoneme assembly (GO:0035082)	2.40335708
84	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.38200255
85	prostate gland growth (GO:0060736)	2.37208611
86	polyol catabolic process (GO:0046174)	2.36492158
87	protoporphyrinogen IX metabolic process (GO:0046501)	2.35943481
88	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.35671776
89	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.35671776
90	olfactory bulb development (GO:0021772)	2.35614152
91	glycerophospholipid catabolic process (GO:0046475)	2.35287205
92	glucosamine-containing compound metabolic process (GO:1901071)	2.34508481
93	dopamine transport (GO:0015872)	2.33957524
94	DNA double-strand break processing (GO:0000729)	2.33101001
95	adaptation of signaling pathway (GO:0023058)	2.31951510
96	positive regulation of meiosis (GO:0045836)	2.31473392
97	L-fucose metabolic process (GO:0042354)	2.31085226
98	L-fucose catabolic process (GO:0042355)	2.31085226
99	fucose catabolic process (GO:0019317)	2.31085226
100	protein neddylation (GO:0045116)	2.31025561

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.88961911
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.80603141
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.57167737
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.34207088
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.23439410
6	GBX2_23144817_ChIP-Seq_PC3_Human	3.17876764
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.89872074
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.73298481
9	VDR_22108803_ChIP-Seq_LS180_Human	2.64425316
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.42137705
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.20301714
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18000067
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10516453
14	FUS_26573619_Chip-Seq_HEK293_Human	2.09091142
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.04859117
16	P300_19829295_ChIP-Seq_ESCs_Human	2.01011257
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.92452788
18	BCAT_22108803_ChIP-Seq_LS180_Human	1.83678992
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.81191370
20	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.79166514
21	EWS_26573619_Chip-Seq_HEK293_Human	1.79127902
22	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.76186116
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75581282
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.75142709
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.73644026
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.72480723
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.67748436
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.66572950
29	STAT3_23295773_ChIP-Seq_U87_Human	1.63571032
30	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.62129826
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61748083
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.61748083
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.60930181
34	TCF4_23295773_ChIP-Seq_U87_Human	1.58968601
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55935536
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55081623
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.54928255
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.53077154
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.51366835
40	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.49396462
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47912309
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46919842
43	AR_25329375_ChIP-Seq_VCAP_Human	1.45239664
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45173253
45	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.44749701
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43151761
47	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42255445
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.42240422
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41920630
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39909329
51	REST_21632747_ChIP-Seq_MESCs_Mouse	1.39544789
52	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39017902
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.34475367
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33630088
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33563788
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32979005
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.29000910
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29000910
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.25138252
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24729172
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23820921
62	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23248678
63	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.21624051
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21407170
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16705816
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.16622092
67	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15321827
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14984957
69	NCOR_22424771_ChIP-Seq_293T_Human	1.14775807
70	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.14360187
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13787714
72	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.13055267
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12734178
74	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.12173280
75	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.12173280
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11909446
77	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10561839
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08649362
79	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07612182
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06960767
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06960767
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06956299
83	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03610749
84	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03568594
85	MYC_18940864_ChIP-ChIP_HL60_Human	1.02512760
86	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01135036
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00506984
88	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.00161022
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99678397
90	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99044215
91	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97828344
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.95493613
93	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.95440413
94	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.94700505
95	KDM2B_26808549_Chip-Seq_REH_Human	0.94285787
96	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.93513549
97	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.91847108
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.91792817
99	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.90186152
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89470767

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.81616831
2	MP0008877_abnormal_DNA_methylation	3.09715232
3	MP0005083_abnormal_biliary_tract	3.09175738
4	MP0008058_abnormal_DNA_repair	2.60874145
5	MP0004043_abnormal_pH_regulation	2.53565306
6	MP0003880_abnormal_central_pattern	2.48760542
7	MP0001529_abnormal_vocalization	2.34529596
8	MP0004885_abnormal_endolymph	2.32857866
9	MP0004147_increased_porphyrin_level	2.27845561
10	MP0005551_abnormal_eye_electrophysiolog	2.07788301
11	MP0005646_abnormal_pituitary_gland	2.03697437
12	MP0002837_dystrophic_cardiac_calcinosis	2.02389495
13	MP0003787_abnormal_imprinting	1.95442198
14	MP0001968_abnormal_touch/_nociception	1.84554032
15	MP0005645_abnormal_hypothalamus_physiol	1.78318451
16	MP0008995_early_reproductive_senescence	1.77509997
17	MP0003121_genomic_imprinting	1.75795943
18	MP0004133_heterotaxia	1.74648720
19	MP0000631_abnormal_neuroendocrine_gland	1.72612135
20	MP0008961_abnormal_basal_metabolism	1.64717673
21	MP0001486_abnormal_startle_reflex	1.63652711
22	MP0002736_abnormal_nociception_after	1.61932360
23	MP0002272_abnormal_nervous_system	1.60694252
24	MP0009745_abnormal_behavioral_response	1.60610570
25	MP0005365_abnormal_bile_salt	1.56759167
26	MP0006292_abnormal_olfactory_placode	1.56149851
27	MP0001501_abnormal_sleep_pattern	1.54665437
28	MP0003011_delayed_dark_adaptation	1.52908149
29	MP0000516_abnormal_urinary_system	1.52013678
30	MP0005367_renal/urinary_system_phenotyp	1.52013678
31	MP0002638_abnormal_pupillary_reflex	1.51763844
32	MP0003252_abnormal_bile_duct	1.50383877
33	MP0009046_muscle_twitch	1.50293465
34	MP0002909_abnormal_adrenal_gland	1.43848361
35	MP0006072_abnormal_retinal_apoptosis	1.43347453
36	MP0000778_abnormal_nervous_system	1.40966016
37	MP0002572_abnormal_emotion/affect_behav	1.40676343
38	MP0004742_abnormal_vestibular_system	1.39633184
39	MP0002822_catalepsy	1.39415975
40	MP0008057_abnormal_DNA_replication	1.38606452
41	MP0004142_abnormal_muscle_tone	1.38434828
42	MP0002735_abnormal_chemical_nociception	1.38398149
43	MP0008872_abnormal_physiological_respon	1.36010104
44	MP0008789_abnormal_olfactory_epithelium	1.35905024
45	MP0002557_abnormal_social/conspecific_i	1.34249738
46	MP0002938_white_spotting	1.30902437
47	MP0005085_abnormal_gallbladder_physiolo	1.30650737
48	MP0005253_abnormal_eye_physiology	1.29767670
49	MP0002163_abnormal_gland_morphology	1.29767328
50	MP0002751_abnormal_autonomic_nervous	1.28744376
51	MP0002102_abnormal_ear_morphology	1.28178853
52	MP0002876_abnormal_thyroid_physiology	1.25664292
53	MP0006276_abnormal_autonomic_nervous	1.23009170
54	MP0005423_abnormal_somatic_nervous	1.22318129
55	MP0003635_abnormal_synaptic_transmissio	1.22096713
56	MP0002063_abnormal_learning/memory/cond	1.20132616
57	MP0002064_seizures	1.19198761
58	MP0002734_abnormal_mechanical_nocicepti	1.18069473
59	MP0001984_abnormal_olfaction	1.17804601
60	MP0000569_abnormal_digit_pigmentation	1.16628973
61	MP0002234_abnormal_pharynx_morphology	1.15960823
62	MP0001905_abnormal_dopamine_level	1.15174163
63	MP0005394_taste/olfaction_phenotype	1.14297310
64	MP0005499_abnormal_olfactory_system	1.14297310
65	MP0002653_abnormal_ependyma_morphology	1.13424307
66	MP0005379_endocrine/exocrine_gland_phen	1.12429749
67	MP0003698_abnormal_male_reproductive	1.11940142
68	MP0002067_abnormal_sensory_capabilities	1.11577610
69	MP0005386_behavior/neurological_phenoty	1.11548275
70	MP0004924_abnormal_behavior	1.11548275
71	MP0002210_abnormal_sex_determination	1.11418363
72	MP0003122_maternal_imprinting	1.11279999
73	MP0001929_abnormal_gametogenesis	1.05569934
74	MP0004270_analgesia	1.03307255
75	MP0010329_abnormal_lipoprotein_level	1.00931577
76	MP0001970_abnormal_pain_threshold	0.99489721
77	MP0002733_abnormal_thermal_nociception	0.98823800
78	MP0005670_abnormal_white_adipose	0.96189097
79	MP0001986_abnormal_taste_sensitivity	0.94971184
80	MP0000955_abnormal_spinal_cord	0.94598610
81	MP0003786_premature_aging	0.92766293
82	MP0001502_abnormal_circadian_rhythm	0.90399461
83	MP0010386_abnormal_urinary_bladder	0.90399258
84	MP0008775_abnormal_heart_ventricle	0.90209700
85	MP0002184_abnormal_innervation	0.90163975
86	MP0000427_abnormal_hair_cycle	0.88415284
87	MP0000653_abnormal_sex_gland	0.88209042
88	MP0002882_abnormal_neuron_morphology	0.87554767
89	MP0005174_abnormal_tail_pigmentation	0.85881898
90	MP0001145_abnormal_male_reproductive	0.85077050
91	MP0001485_abnormal_pinna_reflex	0.83458975
92	MP0003123_paternal_imprinting	0.81960401
93	MP0002229_neurodegeneration	0.81257196
94	MP0005084_abnormal_gallbladder_morpholo	0.81108947
95	MP0002752_abnormal_somatic_nervous	0.80791644
96	MP0002277_abnormal_respiratory_mucosa	0.79175396
97	MP0001324_abnormal_eye_pigmentation	0.78917993
98	MP0002069_abnormal_eating/drinking_beha	0.78889710
99	MP0000026_abnormal_inner_ear	0.78381306
100	MP0005075_abnormal_melanosome_morpholog	0.76995750

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nephronophthisis (HP:0000090)	3.85958852
2	Pancreatic fibrosis (HP:0100732)	3.65552912
3	True hermaphroditism (HP:0010459)	3.65416743
4	Abnormality of the renal medulla (HP:0100957)	3.58182011
5	Pancreatic cysts (HP:0001737)	3.53115255
6	Abnormality of the renal cortex (HP:0011035)	3.51421354
7	Hyperventilation (HP:0002883)	3.48781317
8	Medial flaring of the eyebrow (HP:0010747)	3.40027853
9	Molar tooth sign on MRI (HP:0002419)	3.37638664
10	Abnormality of midbrain morphology (HP:0002418)	3.37638664
11	Gait imbalance (HP:0002141)	2.83220979
12	Intestinal atresia (HP:0011100)	2.82682154
13	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.76717159
14	Tubulointerstitial nephritis (HP:0001970)	2.72327461
15	Cystic liver disease (HP:0006706)	2.66872078
16	Absent speech (HP:0001344)	2.66104040
17	Gaze-evoked nystagmus (HP:0000640)	2.65154997
18	Tubular atrophy (HP:0000092)	2.64454418
19	Congenital primary aphakia (HP:0007707)	2.62804345
20	Congenital stationary night blindness (HP:0007642)	2.60925995
21	Genital tract atresia (HP:0001827)	2.57461744
22	Broad-based gait (HP:0002136)	2.53068092
23	Protruding tongue (HP:0010808)	2.49024975
24	Tubulointerstitial abnormality (HP:0001969)	2.45884491
25	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.44807871
26	Absent/shortened dynein arms (HP:0200106)	2.44807871
27	Renal cortical cysts (HP:0000803)	2.40901515
28	Meckel diverticulum (HP:0002245)	2.40813622
29	Progressive cerebellar ataxia (HP:0002073)	2.40057989
30	Pachygyria (HP:0001302)	2.38933110
31	Vaginal atresia (HP:0000148)	2.38140580
32	Nephrogenic diabetes insipidus (HP:0009806)	2.36885603
33	Abnormality of vitamin B metabolism (HP:0004340)	2.36738956
34	Poor coordination (HP:0002370)	2.36247461
35	Abnormal hair whorl (HP:0010721)	2.35965034
36	Anencephaly (HP:0002323)	2.35820478
37	Abnormality of the ileum (HP:0001549)	2.32972240
38	Postaxial foot polydactyly (HP:0001830)	2.32878961
39	Inability to walk (HP:0002540)	2.32383694
40	Congenital hepatic fibrosis (HP:0002612)	2.30590267
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.29532408
42	Volvulus (HP:0002580)	2.28604933
43	Acute necrotizing encephalopathy (HP:0006965)	2.23404705
44	Azoospermia (HP:0000027)	2.21297903
45	Attenuation of retinal blood vessels (HP:0007843)	2.20218894
46	Progressive inability to walk (HP:0002505)	2.19140413
47	Chronic hepatic failure (HP:0100626)	2.18821918
48	Methylmalonic acidemia (HP:0002912)	2.17034968
49	Drooling (HP:0002307)	2.15341619
50	Fair hair (HP:0002286)	2.14990094
51	Pendular nystagmus (HP:0012043)	2.13735106
52	Sclerocornea (HP:0000647)	2.10458012
53	Astigmatism (HP:0000483)	2.08122225
54	Tubulointerstitial fibrosis (HP:0005576)	2.05586909
55	Type II lissencephaly (HP:0007260)	2.04112229
56	Colon cancer (HP:0003003)	2.04110793
57	Polyuria (HP:0000103)	2.03805671
58	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.03035272
59	Abolished electroretinogram (ERG) (HP:0000550)	2.02891068
60	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.02369398
61	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.02369398
62	Hypothermia (HP:0002045)	2.02239604
63	Postaxial hand polydactyly (HP:0001162)	2.00932847
64	Lissencephaly (HP:0001339)	2.00061187
65	Hyperglycinemia (HP:0002154)	1.98823973
66	Widely spaced teeth (HP:0000687)	1.98666021
67	Abnormal rod and cone electroretinograms (HP:0008323)	1.98470758
68	Clubbing of toes (HP:0100760)	1.94522140
69	Polydipsia (HP:0001959)	1.94488341
70	Abnormal drinking behavior (HP:0030082)	1.94488341
71	Progressive macrocephaly (HP:0004481)	1.94437513
72	Abnormal respiratory epithelium morphology (HP:0012253)	1.94092399
73	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94092399
74	Excessive salivation (HP:0003781)	1.91523636
75	Abnormality of the labia minora (HP:0012880)	1.90709393
76	Abnormality of chromosome stability (HP:0003220)	1.89833539
77	Keratoconus (HP:0000563)	1.89001981
78	Increased corneal curvature (HP:0100692)	1.89001981
79	Focal motor seizures (HP:0011153)	1.87756504
80	Male pseudohermaphroditism (HP:0000037)	1.87311097
81	Optic nerve hypoplasia (HP:0000609)	1.86426601
82	Abnormality of the preputium (HP:0100587)	1.85918667
83	Thyroid-stimulating hormone excess (HP:0002925)	1.81994855
84	Acute encephalopathy (HP:0006846)	1.81920077
85	Abnormal ciliary motility (HP:0012262)	1.81639687
86	Neoplasm of the adrenal cortex (HP:0100641)	1.81639340
87	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.81002673
88	Abnormality of the corticospinal tract (HP:0002492)	1.80623572
89	Febrile seizures (HP:0002373)	1.79788880
90	Mitochondrial inheritance (HP:0001427)	1.79477599
91	Increased hepatocellular lipid droplets (HP:0006565)	1.78417679
92	Gonadotropin excess (HP:0000837)	1.77592138
93	Abnormality of vitamin metabolism (HP:0100508)	1.76810570
94	Polyphagia (HP:0002591)	1.76721494
95	Testicular atrophy (HP:0000029)	1.74623596
96	Abnormal mitochondria in muscle tissue (HP:0008316)	1.74252226
97	Limb dystonia (HP:0002451)	1.70432147
98	Supernumerary spleens (HP:0009799)	1.69590783
99	Stage 5 chronic kidney disease (HP:0003774)	1.68279648
100	Bony spicule pigmentary retinopathy (HP:0007737)	1.68147656

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CCNB1	4.24337903
2	NEK2	3.87307404
3	FRK	3.70564105
4	WNK3	3.37509023
5	MAP4K2	3.02930538
6	NUAK1	2.84820863
7	CAMKK2	2.62667594
8	CAMK1D	2.51545743
9	CASK	2.47440783
10	PINK1	2.41102259
11	GRK1	2.22501769
12	TAF1	2.19891092
13	CAMK1G	2.19867327
14	MAPK13	2.15306742
15	MARK1	2.12075076
16	VRK2	1.98691084
17	NTRK3	1.91613886
18	INSRR	1.88482680
19	ADRBK2	1.61827300
20	WNK4	1.57724528
21	EPHA4	1.49336054
22	BMPR1B	1.47616407
23	MAP3K4	1.46649557
24	PNCK	1.45870199
25	MKNK2	1.34718977
26	DYRK2	1.33892604
27	TNIK	1.32427392
28	ZAK	1.29184698
29	LATS1	1.27149875
30	VRK1	1.24798074
31	PAK3	1.23066189
32	CSNK1G2	1.18583590
33	CAMK1	1.17458557
34	EPHA3	1.12549890
35	CSNK1G1	1.12288625
36	CSNK1G3	1.02421088
37	BCR	1.01748926
38	OXSR1	1.00599454
39	ACVR1B	1.00483285
40	MAP3K7	0.99959580
41	NEK1	0.96180138
42	PRKCE	0.93128086
43	STK39	0.92564091
44	TNK2	0.90994829
45	PRKCG	0.90196491
46	PLK4	0.89571138
47	DAPK2	0.88186469
48	PLK2	0.83406578
49	TSSK6	0.81721654
50	PHKG2	0.81115470
51	PHKG1	0.81115470
52	MAPKAPK5	0.80804341
53	PLK3	0.73494866
54	PKN1	0.71023560
55	STK3	0.68528127
56	NTRK2	0.66119569
57	CHUK	0.64650977
58	MKNK1	0.64383426
59	BRSK2	0.64202961
60	EPHB2	0.63601655
61	MAP2K7	0.62981363
62	TRIM28	0.60838437
63	ADRBK1	0.59542391
64	SIK2	0.59107946
65	CAMKK1	0.58162512
66	FGFR2	0.56067273
67	MINK1	0.55741330
68	CAMK4	0.55053065
69	PRKG1	0.54909619
70	CSNK1A1	0.53594899
71	SGK2	0.52846899
72	TIE1	0.52054075
73	STK38L	0.51473558
74	STK11	0.50171631
75	PTK2B	0.45378387
76	TYRO3	0.44514151
77	GRK5	0.44327521
78	CSNK1A1L	0.42532119
79	IRAK1	0.42266204
80	DYRK1A	0.41068070
81	CSNK1E	0.39272858
82	CAMK2A	0.38638546
83	ATM	0.38571029
84	PRKAA2	0.37039299
85	EIF2AK2	0.36863523
86	MAPK15	0.36611402
87	CDK5	0.35805959
88	SGK494	0.34423572
89	SGK223	0.34423572
90	TLK1	0.34340888
91	WNK1	0.32770651
92	PRKAA1	0.32641750
93	PRKACA	0.32298378
94	UHMK1	0.31932388
95	DYRK3	0.31514528
96	KIT	0.31081931
97	CSNK1D	0.30735353
98	FER	0.30257540
99	FLT3	0.29581752
100	PRKACB	0.29524238

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.06813878
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.94234752
3	Selenocompound metabolism_Homo sapiens_hsa00450	2.86829655
4	Butanoate metabolism_Homo sapiens_hsa00650	2.54351249
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.49883447
6	Nicotine addiction_Homo sapiens_hsa05033	2.49228522
7	Phototransduction_Homo sapiens_hsa04744	2.35028178
8	Propanoate metabolism_Homo sapiens_hsa00640	2.33181768
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10183830
10	Basal transcription factors_Homo sapiens_hsa03022	1.96461777
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.92514655
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.88207219
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.83233138
14	Caffeine metabolism_Homo sapiens_hsa00232	1.81552717
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.79441152
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76506276
17	Homologous recombination_Homo sapiens_hsa03440	1.76245614
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.72529699
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.64142332
20	Insulin secretion_Homo sapiens_hsa04911	1.51956904
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.47261659
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.46089636
23	Parkinsons disease_Homo sapiens_hsa05012	1.45916265
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.43126690
25	Protein export_Homo sapiens_hsa03060	1.42549587
26	Taste transduction_Homo sapiens_hsa04742	1.26457592
27	Glutamatergic synapse_Homo sapiens_hsa04724	1.24712613
28	Cocaine addiction_Homo sapiens_hsa05030	1.24374776
29	Folate biosynthesis_Homo sapiens_hsa00790	1.18604922
30	Regulation of autophagy_Homo sapiens_hsa04140	1.16688165
31	GABAergic synapse_Homo sapiens_hsa04727	1.16090505
32	Fatty acid elongation_Homo sapiens_hsa00062	1.14693831
33	Circadian entrainment_Homo sapiens_hsa04713	1.13608423
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12740921
35	Peroxisome_Homo sapiens_hsa04146	1.12227127
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.09040879
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.08100034
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.06969704
39	Morphine addiction_Homo sapiens_hsa05032	1.06725208
40	One carbon pool by folate_Homo sapiens_hsa00670	1.03946146
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.03330705
42	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.03148137
43	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.01614572
44	Serotonergic synapse_Homo sapiens_hsa04726	1.00849672
45	Lysine degradation_Homo sapiens_hsa00310	1.00825436
46	Retinol metabolism_Homo sapiens_hsa00830	1.00614293
47	Olfactory transduction_Homo sapiens_hsa04740	0.97140150
48	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.96654827
49	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.96240944
50	Non-homologous end-joining_Homo sapiens_hsa03450	0.95666872
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.93176534
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92353974
53	Dopaminergic synapse_Homo sapiens_hsa04728	0.92276596
54	Amphetamine addiction_Homo sapiens_hsa05031	0.92247791
55	Cardiac muscle contraction_Homo sapiens_hsa04260	0.87124821
56	ABC transporters_Homo sapiens_hsa02010	0.86346677
57	Huntingtons disease_Homo sapiens_hsa05016	0.85808533
58	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.85768562
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.84786498
60	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.84714029
61	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.84224806
62	Fatty acid degradation_Homo sapiens_hsa00071	0.83408614
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83038122
64	Mismatch repair_Homo sapiens_hsa03430	0.80721133
65	Axon guidance_Homo sapiens_hsa04360	0.78330616
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76751795
67	Histidine metabolism_Homo sapiens_hsa00340	0.75439344
68	RNA polymerase_Homo sapiens_hsa03020	0.75260112
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.73674991
70	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.72605861
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71497856
72	Base excision repair_Homo sapiens_hsa03410	0.70739201
73	RNA degradation_Homo sapiens_hsa03018	0.68001726
74	Renin-angiotensin system_Homo sapiens_hsa04614	0.66360273
75	cAMP signaling pathway_Homo sapiens_hsa04024	0.66023960
76	Salivary secretion_Homo sapiens_hsa04970	0.65438068
77	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.63319126
78	Circadian rhythm_Homo sapiens_hsa04710	0.63279041
79	Alzheimers disease_Homo sapiens_hsa05010	0.62395058
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59272373
81	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.58016084
82	Long-term depression_Homo sapiens_hsa04730	0.57942840
83	Metabolic pathways_Homo sapiens_hsa01100	0.53986028
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.50384341
85	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.50304051
86	Basal cell carcinoma_Homo sapiens_hsa05217	0.50280976
87	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.49251061
88	Cholinergic synapse_Homo sapiens_hsa04725	0.47560372
89	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.46573882
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.46544874
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.45980997
92	Nucleotide excision repair_Homo sapiens_hsa03420	0.44654636
93	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.43597067
94	Oocyte meiosis_Homo sapiens_hsa04114	0.42786616
95	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42764986
96	Sulfur metabolism_Homo sapiens_hsa00920	0.42757289
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.42409097
98	Renin secretion_Homo sapiens_hsa04924	0.42075204
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40668755
100	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.40351730

ZNF135

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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