ZNF136

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) A-box domain at its N-terminus, followed by fourteen contiguous C2H2 zinc finger domains and a degenerate zinc finger. The KRAB A-box showed weak transcriptional repressor activity in a reporter gene assay. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.67759245
2negative regulation of translation, ncRNA-mediated (GO:0040033)4.45611378
3regulation of translation, ncRNA-mediated (GO:0045974)4.45611378
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.45611378
5attachment of spindle microtubules to kinetochore (GO:0008608)4.41712607
6water-soluble vitamin biosynthetic process (GO:0042364)4.37627955
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.26991313
8protein K11-linked deubiquitination (GO:0035871)4.12031553
9regulation of cilium movement (GO:0003352)4.04470375
10intraciliary transport (GO:0042073)3.83851646
11piRNA metabolic process (GO:0034587)3.73244660
12neural tube formation (GO:0001841)3.66682188
13RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.39524582
14microtubule anchoring (GO:0034453)3.38641170
15male meiosis I (GO:0007141)3.33441762
16protein prenylation (GO:0018342)3.33259632
17prenylation (GO:0097354)3.33259632
18DNA deamination (GO:0045006)3.25854935
19regulation of meiosis I (GO:0060631)3.22993305
20retinal cone cell development (GO:0046549)3.19203994
21centriole replication (GO:0007099)3.16995309
22reciprocal meiotic recombination (GO:0007131)3.16599981
23reciprocal DNA recombination (GO:0035825)3.16599981
24establishment of protein localization to Golgi (GO:0072600)3.11147963
25negative regulation of mast cell activation (GO:0033004)3.10535179
26epithelial cilium movement (GO:0003351)3.10025881
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.07373236
28axoneme assembly (GO:0035082)3.06120256
29activated T cell proliferation (GO:0050798)3.04549009
30cilium morphogenesis (GO:0060271)3.03478638
31RNA destabilization (GO:0050779)2.98831339
32platelet dense granule organization (GO:0060155)2.95036728
33protein targeting to Golgi (GO:0000042)2.94312464
34regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.94192763
35histone H3-K9 methylation (GO:0051567)2.92830634
36DNA methylation involved in gamete generation (GO:0043046)2.92650636
37L-fucose catabolic process (GO:0042355)2.92375877
38fucose catabolic process (GO:0019317)2.92375877
39L-fucose metabolic process (GO:0042354)2.92375877
40indole-containing compound catabolic process (GO:0042436)2.90410388
41indolalkylamine catabolic process (GO:0046218)2.90410388
42tryptophan catabolic process (GO:0006569)2.90410388
43peptidyl-histidine modification (GO:0018202)2.85093748
44synapsis (GO:0007129)2.84248248
45protein localization to cilium (GO:0061512)2.83961564
46nonmotile primary cilium assembly (GO:0035058)2.82098237
47indolalkylamine metabolic process (GO:0006586)2.82070988
48negative regulation of telomere maintenance (GO:0032205)2.81316032
49DNA demethylation (GO:0080111)2.80811473
50cilium organization (GO:0044782)2.80721160
51regulation of nuclear cell cycle DNA replication (GO:0033262)2.78880716
52photoreceptor cell maintenance (GO:0045494)2.77668848
53cilium assembly (GO:0042384)2.74234950
54histone mRNA catabolic process (GO:0071044)2.73933657
55protein polyglutamylation (GO:0018095)2.73901297
56regulation of telomere maintenance (GO:0032204)2.72112139
57production of molecular mediator involved in inflammatory response (GO:0002532)2.68873731
58neuron fate determination (GO:0048664)2.67512363
59microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.67162603
60regulation of hexokinase activity (GO:1903299)2.67135190
61regulation of glucokinase activity (GO:0033131)2.67135190
62signal peptide processing (GO:0006465)2.66336333
63somite rostral/caudal axis specification (GO:0032525)2.65870053
64centriole assembly (GO:0098534)2.65209052
65regulation of helicase activity (GO:0051095)2.65128983
66adenosine metabolic process (GO:0046085)2.63490064
67male meiosis (GO:0007140)2.63464233
68protein localization to Golgi apparatus (GO:0034067)2.62584442
69behavioral response to nicotine (GO:0035095)2.61601448
70regulation of microtubule-based movement (GO:0060632)2.60465334
71meiosis I (GO:0007127)2.59606223
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.59533190
73gene silencing by RNA (GO:0031047)2.57387245
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56016842
75negative regulation of DNA recombination (GO:0045910)2.55508751
76nerve growth factor signaling pathway (GO:0038180)2.55257916
77retina layer formation (GO:0010842)2.54226434
78monoubiquitinated protein deubiquitination (GO:0035520)2.53691236
79retrograde transport, vesicle recycling within Golgi (GO:0000301)2.52627123
80RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51708165
81tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51708165
82tryptophan metabolic process (GO:0006568)2.51484637
83protein-cofactor linkage (GO:0018065)2.51483106
84negative regulation of DNA-dependent DNA replication (GO:2000104)2.48915341
85S-adenosylmethionine metabolic process (GO:0046500)2.47537796
86cAMP catabolic process (GO:0006198)2.47432874
87positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.46789088
88mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.46789088
89meiotic cell cycle (GO:0051321)2.45874463
90kynurenine metabolic process (GO:0070189)2.45498664
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.42882777
92regulation of mitotic spindle checkpoint (GO:1903504)2.42882777
93interkinetic nuclear migration (GO:0022027)2.40152615
94histone H3-K4 trimethylation (GO:0080182)2.38388849
95negative regulation of transcription regulatory region DNA binding (GO:2000678)2.36194071
96histone H2A acetylation (GO:0043968)2.35347970
97DNA integration (GO:0015074)2.35187052
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.33480557
99detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.32578139
100primary amino compound metabolic process (GO:1901160)2.30361463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.33854430
2IGF1R_20145208_ChIP-Seq_DFB_Human2.94173898
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.88056454
4VDR_22108803_ChIP-Seq_LS180_Human2.84809233
5GBX2_23144817_ChIP-Seq_PC3_Human2.72094345
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.67327389
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.62817380
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53517485
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.49670314
10EWS_26573619_Chip-Seq_HEK293_Human2.34605070
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31432023
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13510695
13TAF15_26573619_Chip-Seq_HEK293_Human2.13307266
14FUS_26573619_Chip-Seq_HEK293_Human2.10155419
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09941811
16P300_19829295_ChIP-Seq_ESCs_Human2.07535726
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.05981688
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03211251
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95641727
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93358764
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92878281
22ER_23166858_ChIP-Seq_MCF-7_Human1.92349038
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92090411
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91007852
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83064308
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73634319
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.68605983
28CBP_20019798_ChIP-Seq_JUKART_Human1.65879406
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65879406
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62617043
31IRF1_19129219_ChIP-ChIP_H3396_Human1.61197823
32ELK1_19687146_ChIP-ChIP_HELA_Human1.60563694
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60421846
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.57743903
35SMAD4_21799915_ChIP-Seq_A2780_Human1.57469312
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56872291
37BCAT_22108803_ChIP-Seq_LS180_Human1.55072120
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54969947
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54875561
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53658103
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52743885
42EZH2_22144423_ChIP-Seq_EOC_Human1.51710630
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51015655
44* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48830363
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47647267
46STAT3_23295773_ChIP-Seq_U87_Human1.46936090
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43869106
48VDR_23849224_ChIP-Seq_CD4+_Human1.42968785
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.41545658
50* AR_25329375_ChIP-Seq_VCAP_Human1.40806466
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.40761993
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.39834802
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37263779
54MYC_18940864_ChIP-ChIP_HL60_Human1.36045197
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36011264
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.33254142
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.31988733
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31648520
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31629765
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30885749
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30741121
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30357369
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30195773
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29558828
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29558828
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29085030
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.28504125
68TCF4_23295773_ChIP-Seq_U87_Human1.26525340
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.25549645
70* TCF4_22108803_ChIP-Seq_LS180_Human1.22663390
71TP53_22573176_ChIP-Seq_HFKS_Human1.22548826
72RNF2_27304074_Chip-Seq_NSC_Mouse1.21954423
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.21851481
74P53_22387025_ChIP-Seq_ESCs_Mouse1.21373248
75RUNX2_22187159_ChIP-Seq_PCA_Human1.19894445
76SOX2_19829295_ChIP-Seq_ESCs_Human1.19682975
77NANOG_19829295_ChIP-Seq_ESCs_Human1.19682975
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.19356629
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19334535
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.17766360
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.16772992
82* CDX2_22108803_ChIP-Seq_LS180_Human1.16088676
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15277725
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15265451
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14970873
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13057025
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12884221
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.12391666
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11732582
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.09721449
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.09680284
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07451843
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06935454
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06490402
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06464496
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05090578
97GATA3_26560356_Chip-Seq_TH2_Human1.04653448
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.03944999
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03092868
100P300_18555785_Chip-Seq_ESCs_Mouse1.02966541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.96614921
2MP0003195_calcinosis2.80009655
3MP0008057_abnormal_DNA_replication2.65722421
4MP0008789_abnormal_olfactory_epithelium2.65221522
5MP0005084_abnormal_gallbladder_morpholo2.63813648
6MP0001529_abnormal_vocalization2.50050657
7MP0002102_abnormal_ear_morphology2.45918144
8MP0008058_abnormal_DNA_repair2.31029640
9MP0005394_taste/olfaction_phenotype2.15485456
10MP0005499_abnormal_olfactory_system2.15485456
11MP0006276_abnormal_autonomic_nervous2.08524205
12MP0006292_abnormal_olfactory_placode2.01439927
13MP0003880_abnormal_central_pattern1.95986863
14MP0000569_abnormal_digit_pigmentation1.94442548
15MP0003787_abnormal_imprinting1.92312073
16MP0002928_abnormal_bile_duct1.87562040
17MP0001986_abnormal_taste_sensitivity1.81923246
18MP0000631_abnormal_neuroendocrine_gland1.69378881
19MP0001984_abnormal_olfaction1.68963834
20MP0005253_abnormal_eye_physiology1.66753238
21MP0005645_abnormal_hypothalamus_physiol1.64906464
22MP0004133_heterotaxia1.64765349
23MP0001968_abnormal_touch/_nociception1.57955671
24MP0005551_abnormal_eye_electrophysiolog1.57659557
25MP0006072_abnormal_retinal_apoptosis1.55179664
26MP0002736_abnormal_nociception_after1.53486977
27MP0000427_abnormal_hair_cycle1.49723093
28MP0002837_dystrophic_cardiac_calcinosis1.49560924
29MP0004142_abnormal_muscle_tone1.48102856
30MP0008995_early_reproductive_senescence1.47635291
31MP0002095_abnormal_skin_pigmentation1.46350486
32MP0009046_muscle_twitch1.46092572
33MP0000372_irregular_coat_pigmentation1.45358151
34MP0003252_abnormal_bile_duct1.43105077
35MP0001501_abnormal_sleep_pattern1.41946649
36MP0002138_abnormal_hepatobiliary_system1.41346049
37MP0001293_anophthalmia1.41100648
38MP0002876_abnormal_thyroid_physiology1.41034765
39MP0002277_abnormal_respiratory_mucosa1.41001048
40MP0003890_abnormal_embryonic-extraembry1.37668218
41MP0001485_abnormal_pinna_reflex1.37500264
42MP0008961_abnormal_basal_metabolism1.36032356
43MP0001929_abnormal_gametogenesis1.34770364
44MP0003718_maternal_effect1.33672408
45MP0002638_abnormal_pupillary_reflex1.33496181
46MP0005075_abnormal_melanosome_morpholog1.33160264
47MP0002938_white_spotting1.32103866
48MP0001919_abnormal_reproductive_system1.29482782
49MP0005646_abnormal_pituitary_gland1.26581060
50MP0009745_abnormal_behavioral_response1.26528385
51MP0004043_abnormal_pH_regulation1.25740077
52MP0002163_abnormal_gland_morphology1.25666197
53MP0002653_abnormal_ependyma_morphology1.25505536
54MP0002210_abnormal_sex_determination1.22849884
55MP0001486_abnormal_startle_reflex1.22746833
56MP0005379_endocrine/exocrine_gland_phen1.19850502
57MP0003121_genomic_imprinting1.17585275
58MP0005671_abnormal_response_to1.16270204
59MP0000653_abnormal_sex_gland1.14090290
60MP0002735_abnormal_chemical_nociception1.13071882
61MP0005389_reproductive_system_phenotype1.12880188
62MP0002272_abnormal_nervous_system1.09183762
63MP0003698_abnormal_male_reproductive1.01199899
64MP0002822_catalepsy0.99280255
65MP0005174_abnormal_tail_pigmentation0.99104363
66MP0001119_abnormal_female_reproductive0.97381719
67MP0001145_abnormal_male_reproductive0.97334120
68MP0002557_abnormal_social/conspecific_i0.97131210
69MP0003122_maternal_imprinting0.94065534
70MP0005386_behavior/neurological_phenoty0.93499212
71MP0004924_abnormal_behavior0.93499212
72MP0003136_yellow_coat_color0.92432456
73MP0001188_hyperpigmentation0.92170159
74MP0005266_abnormal_metabolism0.91237226
75MP0003119_abnormal_digestive_system0.89261314
76MP0005647_abnormal_sex_gland0.85752630
77MP0005187_abnormal_penis_morphology0.83237039
78MP0002067_abnormal_sensory_capabilities0.82802325
79MP0003646_muscle_fatigue0.82559862
80MP0004885_abnormal_endolymph0.82432230
81MP0002572_abnormal_emotion/affect_behav0.81355689
82MP0001835_abnormal_antigen_presentation0.81051985
83MP0004147_increased_porphyrin_level0.80260972
84MP0001800_abnormal_humoral_immune0.79391077
85MP0003828_pulmonary_edema0.79360641
86MP0002751_abnormal_autonomic_nervous0.78593210
87MP0002160_abnormal_reproductive_system0.77994581
88MP0005391_vision/eye_phenotype0.77965016
89MP0009764_decreased_sensitivity_to0.77344058
90MP0002090_abnormal_vision0.76899451
91MP0008872_abnormal_physiological_respon0.76731217
92MP0005310_abnormal_salivary_gland0.76635873
93MP0000015_abnormal_ear_pigmentation0.76560710
94MP0004215_abnormal_myocardial_fiber0.74938845
95MP0000383_abnormal_hair_follicle0.74776535
96MP0001764_abnormal_homeostasis0.74529080
97MP0003724_increased_susceptibility_to0.73716864
98MP0008875_abnormal_xenobiotic_pharmacok0.73397035
99MP0000647_abnormal_sebaceous_gland0.70674114
100MP0003693_abnormal_embryo_hatching0.68919193

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.95607464
2Pancreatic fibrosis (HP:0100732)3.34141541
3Medial flaring of the eyebrow (HP:0010747)3.26117434
4Methylmalonic acidemia (HP:0002912)3.06332769
5True hermaphroditism (HP:0010459)3.01862238
6Volvulus (HP:0002580)3.00418493
7Abnormality of midbrain morphology (HP:0002418)2.95769212
8Molar tooth sign on MRI (HP:0002419)2.95769212
9Amyotrophic lateral sclerosis (HP:0007354)2.94042386
10Congenital primary aphakia (HP:0007707)2.89552117
11Gait imbalance (HP:0002141)2.83436256
12Abnormality of the renal cortex (HP:0011035)2.83268780
13Nephrogenic diabetes insipidus (HP:0009806)2.81107395
14Nephronophthisis (HP:0000090)2.77896056
15Intestinal atresia (HP:0011100)2.77886934
16Hyperglycinemia (HP:0002154)2.73641444
17Oligodactyly (hands) (HP:0001180)2.69647471
18Alveolar cell carcinoma (HP:0006519)2.64800258
19Gaze-evoked nystagmus (HP:0000640)2.61448933
20Abnormality of the renal medulla (HP:0100957)2.61022159
21Attenuation of retinal blood vessels (HP:0007843)2.59811954
22Progressive inability to walk (HP:0002505)2.54413720
23Genital tract atresia (HP:0001827)2.52056648
24Neoplasm of the tracheobronchial system (HP:0100552)2.49974008
25Type II lissencephaly (HP:0007260)2.49958938
26Vaginal atresia (HP:0000148)2.43620559
27Abolished electroretinogram (ERG) (HP:0000550)2.38009911
28Hyperventilation (HP:0002883)2.37025151
29Atonic seizures (HP:0010819)2.36688920
30Supernumerary spleens (HP:0009799)2.34521634
31Renal cortical cysts (HP:0000803)2.32190848
32Stomach cancer (HP:0012126)2.30595216
33Hypothermia (HP:0002045)2.29135856
34Febrile seizures (HP:0002373)2.26743913
35Decreased central vision (HP:0007663)2.26375362
36Methylmalonic aciduria (HP:0012120)2.23254562
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16841626
38Cerebellar dysplasia (HP:0007033)2.15988450
39Abnormal rod and cone electroretinograms (HP:0008323)2.12535763
40Polydipsia (HP:0001959)2.11519908
41Abnormal drinking behavior (HP:0030082)2.11519908
42Chronic hepatic failure (HP:0100626)2.09387984
43Fair hair (HP:0002286)2.08620094
44Widely spaced teeth (HP:0000687)2.07325466
45Abnormality of the labia minora (HP:0012880)2.06098408
46Poor coordination (HP:0002370)2.05596392
47Cystic liver disease (HP:0006706)2.05569517
48Congenital hepatic fibrosis (HP:0002612)2.03996653
49Degeneration of anterior horn cells (HP:0002398)2.01344463
50Abnormality of the anterior horn cell (HP:0006802)2.01344463
51Postaxial hand polydactyly (HP:0001162)2.01316533
52Pendular nystagmus (HP:0012043)1.98008802
53Absent speech (HP:0001344)1.97525894
54Congenital stationary night blindness (HP:0007642)1.97119240
55Aplasia/Hypoplasia of the tongue (HP:0010295)1.96967575
56Septo-optic dysplasia (HP:0100842)1.95690070
57Bile duct proliferation (HP:0001408)1.94020154
58Abnormal biliary tract physiology (HP:0012439)1.94020154
59Abnormality of macular pigmentation (HP:0008002)1.93472465
60Male pseudohermaphroditism (HP:0000037)1.93219650
61Optic nerve hypoplasia (HP:0000609)1.92368481
62Lissencephaly (HP:0001339)1.92088632
63Congenital sensorineural hearing impairment (HP:0008527)1.91692446
64Inability to walk (HP:0002540)1.91172711
65Protruding tongue (HP:0010808)1.90897422
66Atrophy/Degeneration involving motor neurons (HP:0007373)1.87538366
67Abnormality of glycine metabolism (HP:0010895)1.87529013
68Abnormality of serine family amino acid metabolism (HP:0010894)1.87529013
69Aplasia/hypoplasia of the uterus (HP:0008684)1.86594027
70Dialeptic seizures (HP:0011146)1.86482992
71Aplasia/Hypoplasia of the tibia (HP:0005772)1.84367946
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83760142
73Generalized hypopigmentation of hair (HP:0011358)1.83575914
74Abnormality of vitamin B metabolism (HP:0004340)1.83170378
75Tubular atrophy (HP:0000092)1.82420380
76Anencephaly (HP:0002323)1.81584025
77Postaxial foot polydactyly (HP:0001830)1.81278852
78Thyroiditis (HP:0100646)1.79481181
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78974744
80Abnormality of alanine metabolism (HP:0010916)1.78974744
81Hyperalaninemia (HP:0003348)1.78974744
82Median cleft lip (HP:0000161)1.75837103
83Aplastic anemia (HP:0001915)1.75746638
84Abnormality of B cell number (HP:0010975)1.74085765
85Abnormality of the vitamin B12 metabolism (HP:0004341)1.73237596
86Specific learning disability (HP:0001328)1.73207665
87Hip dysplasia (HP:0001385)1.68995251
88Broad-based gait (HP:0002136)1.67699280
89Hemiparesis (HP:0001269)1.66908124
90Abnormality of the fovea (HP:0000493)1.65344242
91Abnormal delayed hypersensitivity skin test (HP:0002963)1.64375228
92Left ventricular hypertrophy (HP:0001712)1.63267824
93Large for gestational age (HP:0001520)1.62879829
94Progressive cerebellar ataxia (HP:0002073)1.62588314
95Drooling (HP:0002307)1.59600524
96Short foot (HP:0001773)1.59364081
97Stomatitis (HP:0010280)1.59355305
98B lymphocytopenia (HP:0010976)1.58710912
99Multicystic kidney dysplasia (HP:0000003)1.57851821
100Preaxial hand polydactyly (HP:0001177)1.57491511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.12964652
2WNK32.89348487
3TRIM282.49842070
4TXK2.43037115
5ZAK2.24625878
6BMPR1B2.09828677
7ACVR1B2.06819374
8NUAK12.05474889
9TNIK2.02025296
10TAOK32.00030525
11BCR1.88443243
12MST41.87074436
13PINK11.86346564
14CASK1.83921155
15ADRBK21.82325531
16MAP4K21.79173171
17MKNK21.75514030
18MAP3K41.70761150
19BRSK21.68782469
20CAMKK21.67845672
21STK38L1.67678680
22NEK11.44090510
23GRK11.42517257
24TEC1.42216408
25EPHA31.36821366
26VRK11.35844175
27OXSR11.34368402
28INSRR1.33602584
29FES1.31343009
30MAPK131.18059347
31PASK1.16796622
32STK391.12782625
33FER1.07318833
34TLK11.05038147
35PAK31.04701792
36STK161.04529230
37MAP3K50.99604302
38NTRK20.99483490
39MKNK10.97329458
40CDK190.90928132
41ITK0.90891055
42KIT0.90855403
43PRKCE0.88963770
44MUSK0.87798443
45EPHA40.86849072
46PLK20.85847983
47NLK0.82340073
48DAPK20.81904761
49ERBB30.80375723
50MAP2K70.80266187
51CSNK1G20.78685550
52CHUK0.78321266
53TGFBR10.77686859
54TAF10.77099390
55PRKCI0.75256888
56DYRK30.74824873
57IKBKB0.74329293
58CSNK1G10.74098040
59CSNK1G30.70281364
60PLK30.70141063
61PIK3CA0.70086659
62IKBKE0.69176692
63STK30.68962619
64STK240.68602118
65GRK70.68352587
66PRKCQ0.67766394
67AKT30.67350184
68CCNB10.64779908
69EIF2AK30.61804466
70IRAK10.60825758
71SRPK10.60265372
72PKN10.59350978
73ATR0.58401683
74RPS6KA50.55662051
75SYK0.55586573
76PRKCG0.55287330
77CDK60.52514051
78WNK40.51041943
79DYRK1A0.50617001
80MATK0.50355994
81PNCK0.50019598
82CSNK1A1L0.49406578
83DYRK20.49063376
84ADRBK10.46980833
85LYN0.46431132
86SIK30.46075352
87NEK60.44017813
88LCK0.43936867
89EGFR0.42475038
90FGFR20.42172622
91BCKDK0.42058383
92FLT30.41354979
93ATM0.40779896
94YES10.39445829
95BRD40.39188766
96CAMK10.37715407
97SGK20.36861234
98MARK30.35775235
99CAMK2A0.35645987
100CSF1R0.35153036

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.84791123
2Basal transcription factors_Homo sapiens_hsa030222.80977427
3Protein export_Homo sapiens_hsa030602.67366241
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.41765125
5RNA degradation_Homo sapiens_hsa030182.41498071
6Phototransduction_Homo sapiens_hsa047442.25265456
7Butanoate metabolism_Homo sapiens_hsa006502.21588054
8Nitrogen metabolism_Homo sapiens_hsa009102.05840440
9Homologous recombination_Homo sapiens_hsa034402.03003292
10Regulation of autophagy_Homo sapiens_hsa041401.98275592
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.96793310
12Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.89125990
13RNA polymerase_Homo sapiens_hsa030201.84495293
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83644506
15Propanoate metabolism_Homo sapiens_hsa006401.80929922
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74580635
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.70929090
18Fanconi anemia pathway_Homo sapiens_hsa034601.68475403
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63394005
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63344349
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.62114368
22Asthma_Homo sapiens_hsa053101.61898560
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61853745
24Non-homologous end-joining_Homo sapiens_hsa034501.60250174
25Olfactory transduction_Homo sapiens_hsa047401.59826608
26Type I diabetes mellitus_Homo sapiens_hsa049401.56807808
27Selenocompound metabolism_Homo sapiens_hsa004501.54891053
28Graft-versus-host disease_Homo sapiens_hsa053321.54733651
29Taste transduction_Homo sapiens_hsa047421.53252932
30Autoimmune thyroid disease_Homo sapiens_hsa053201.42141283
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40897412
32Primary immunodeficiency_Homo sapiens_hsa053401.40094743
33Nicotine addiction_Homo sapiens_hsa050331.37719464
34GABAergic synapse_Homo sapiens_hsa047271.37464129
35Allograft rejection_Homo sapiens_hsa053301.37149101
36Caffeine metabolism_Homo sapiens_hsa002321.35326360
37Linoleic acid metabolism_Homo sapiens_hsa005911.32548779
38Circadian rhythm_Homo sapiens_hsa047101.29902821
39Ether lipid metabolism_Homo sapiens_hsa005651.28591692
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28155138
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27954734
42Steroid biosynthesis_Homo sapiens_hsa001001.08408041
43Morphine addiction_Homo sapiens_hsa050321.07147520
44Peroxisome_Homo sapiens_hsa041461.03171356
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98759232
46Oxidative phosphorylation_Homo sapiens_hsa001900.96597511
47Collecting duct acid secretion_Homo sapiens_hsa049660.93892296
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92387436
49Tryptophan metabolism_Homo sapiens_hsa003800.91245733
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.88344027
51Rheumatoid arthritis_Homo sapiens_hsa053230.86612203
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86575251
53p53 signaling pathway_Homo sapiens_hsa041150.85536550
54Parkinsons disease_Homo sapiens_hsa050120.85022246
55Serotonergic synapse_Homo sapiens_hsa047260.83865454
56RNA transport_Homo sapiens_hsa030130.83590074
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80498471
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77195814
59Sulfur metabolism_Homo sapiens_hsa009200.73978824
60Oocyte meiosis_Homo sapiens_hsa041140.71390107
61Hedgehog signaling pathway_Homo sapiens_hsa043400.69861916
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69525095
63Circadian entrainment_Homo sapiens_hsa047130.67689409
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.66935998
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65728535
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63828630
67One carbon pool by folate_Homo sapiens_hsa006700.63367506
68Glutamatergic synapse_Homo sapiens_hsa047240.61898494
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61425818
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58677010
71Purine metabolism_Homo sapiens_hsa002300.57384517
72Ovarian steroidogenesis_Homo sapiens_hsa049130.56939912
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55192059
74Huntingtons disease_Homo sapiens_hsa050160.53975222
75Systemic lupus erythematosus_Homo sapiens_hsa053220.53814933
76ABC transporters_Homo sapiens_hsa020100.53336567
77Dorso-ventral axis formation_Homo sapiens_hsa043200.53224555
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.50654334
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50371887
80Fatty acid elongation_Homo sapiens_hsa000620.48949887
81Herpes simplex infection_Homo sapiens_hsa051680.48852265
82Arachidonic acid metabolism_Homo sapiens_hsa005900.48743355
83Dopaminergic synapse_Homo sapiens_hsa047280.48558048
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47061555
85Insulin secretion_Homo sapiens_hsa049110.46478256
86Amphetamine addiction_Homo sapiens_hsa050310.45688300
87Legionellosis_Homo sapiens_hsa051340.45518479
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44995274
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44575320
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44425891
91Long-term depression_Homo sapiens_hsa047300.43709196
92Cell cycle_Homo sapiens_hsa041100.42500997
93Spliceosome_Homo sapiens_hsa030400.42374412
94Hematopoietic cell lineage_Homo sapiens_hsa046400.42271232
95Alcoholism_Homo sapiens_hsa050340.41547617
96Proteasome_Homo sapiens_hsa030500.41278546
97TGF-beta signaling pathway_Homo sapiens_hsa043500.36041847
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35529454
99Renin secretion_Homo sapiens_hsa049240.34407422
100Metabolic pathways_Homo sapiens_hsa011000.33235684

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