ZNF137P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.46417845
2nuclear pore complex assembly (GO:0051292)4.76343224
3regulation of B cell receptor signaling pathway (GO:0050855)4.51180189
4negative regulation of cell killing (GO:0031342)4.29106232
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.29106232
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.20089871
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.15480130
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.15480130
9modulation by symbiont of host immune response (GO:0052553)4.15480130
10positive regulation by symbiont of host defense response (GO:0052509)4.15480130
11modulation by symbiont of host defense response (GO:0052031)4.15480130
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.15480130
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.05153928
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.03698640
15negative regulation of interleukin-1 beta production (GO:0032691)3.99601601
16B cell receptor signaling pathway (GO:0050853)3.98550157
17histone H3-K36 demethylation (GO:0070544)3.87852125
18antigen processing and presentation of endogenous antigen (GO:0019883)3.87358883
19response to interleukin-15 (GO:0070672)3.78542562
20regulation of gamma-delta T cell activation (GO:0046643)3.78468140
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.74770068
22regulation of histone H3-K27 methylation (GO:0061085)3.72441845
23nuclear pore organization (GO:0006999)3.69944895
24regulation of gamma-delta T cell differentiation (GO:0045586)3.66540860
25negative regulation of interleukin-1 production (GO:0032692)3.64528633
26regulation of interferon-beta biosynthetic process (GO:0045357)3.63274288
27regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.60360659
28pore complex assembly (GO:0046931)3.47560873
29germinal center formation (GO:0002467)3.43727982
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.42628341
31positive regulation of growth hormone secretion (GO:0060124)3.38519960
32response to peptidoglycan (GO:0032494)3.20020400
33positive regulation of B cell differentiation (GO:0045579)3.19624210
34negative thymic T cell selection (GO:0045060)3.14890028
35positive regulation of granulocyte differentiation (GO:0030854)3.13624586
36neutrophil activation involved in immune response (GO:0002283)3.11887397
37regulation of interleukin-6 biosynthetic process (GO:0045408)3.11625024
38detection of other organism (GO:0098543)3.09482390
39cellular response to interleukin-15 (GO:0071350)3.05308200
40detection of molecule of bacterial origin (GO:0032490)3.05084343
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05062390
42response to host immune response (GO:0052572)3.05062390
43negative T cell selection (GO:0043383)3.04429036
44macrophage activation involved in immune response (GO:0002281)3.03059913
45cellular extravasation (GO:0045123)3.01572776
46response to host (GO:0075136)2.98605055
47response to host defenses (GO:0052200)2.98605055
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.98605055
49negative regulation of lymphocyte mediated immunity (GO:0002707)2.93652385
50negative regulation of T-helper cell differentiation (GO:0045623)2.91202143
51negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.91202143
52T cell homeostasis (GO:0043029)2.89518436
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.88969047
54regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.88322624
55regulation of RNA export from nucleus (GO:0046831)2.87189693
56regulation of B cell differentiation (GO:0045577)2.86895323
57negative regulation of erythrocyte differentiation (GO:0045647)2.86612640
58response to muramyl dipeptide (GO:0032495)2.86609769
59detection of bacterium (GO:0016045)2.83854813
60detection of external biotic stimulus (GO:0098581)2.81351514
61negative regulation of interleukin-12 production (GO:0032695)2.79029230
62histone H3-K4 trimethylation (GO:0080182)2.77822071
63thymic T cell selection (GO:0045061)2.76831579
64leukocyte aggregation (GO:0070486)2.76654974
65positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.75524518
66embryonic process involved in female pregnancy (GO:0060136)2.74781028
67positive thymic T cell selection (GO:0045059)2.74582253
68negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.74539977
69interferon-gamma secretion (GO:0072643)2.73802947
70negative regulation of T cell mediated immunity (GO:0002710)2.72541202
71phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.72516192
72T cell selection (GO:0045058)2.69714148
73JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.69590217
74positive regulation of interferon-alpha production (GO:0032727)2.69194341
75cellular response to type I interferon (GO:0071357)2.68778727
76type I interferon signaling pathway (GO:0060337)2.68778727
77response to type I interferon (GO:0034340)2.68196053
78iron ion import (GO:0097286)2.65475356
79histone lysine demethylation (GO:0070076)2.60647192
80negative regulation of leukocyte mediated immunity (GO:0002704)2.60484663
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.60474720
82positive T cell selection (GO:0043368)2.59603407
83B cell homeostasis (GO:0001782)2.58819532
84lymphocyte homeostasis (GO:0002260)2.58686778
85regulation of nucleobase-containing compound transport (GO:0032239)2.58050906
86neutrophil activation (GO:0042119)2.57182167
87hepatocyte apoptotic process (GO:0097284)2.55893342
88regulation of growth hormone secretion (GO:0060123)2.53396023
89Peyers patch development (GO:0048541)2.51972623
90mucosal-associated lymphoid tissue development (GO:0048537)2.51972623
91regulation of T-helper 2 cell differentiation (GO:0045628)2.51492128
92regulation of necroptotic process (GO:0060544)2.47799031
93negative regulation of interleukin-6 production (GO:0032715)2.46524507
94B cell proliferation (GO:0042100)2.46414355
95histone demethylation (GO:0016577)2.45972699
96production of molecular mediator involved in inflammatory response (GO:0002532)2.45759502
97definitive hemopoiesis (GO:0060216)2.45211867
98immunoglobulin mediated immune response (GO:0016064)2.43519910
99regulation of granulocyte differentiation (GO:0030852)2.40448115
1003-UTR-mediated mRNA stabilization (GO:0070935)2.39742214

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.43834023
2E2F7_22180533_ChIP-Seq_HELA_Human4.28365595
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.25382537
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.95719821
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.42627159
6GATA1_22025678_ChIP-Seq_K562_Human3.31141041
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.26996427
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.03122098
9MYC_22102868_ChIP-Seq_BL_Human3.03073628
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.84311960
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64602880
12MYB_26560356_Chip-Seq_TH2_Human2.53881518
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.53309522
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47633590
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40353259
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35898073
17MYB_26560356_Chip-Seq_TH1_Human2.35108045
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.32327759
19SPI1_23547873_ChIP-Seq_NB4_Human2.31265472
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.26797531
21SPI1_23127762_ChIP-Seq_K562_Human2.22615446
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19204948
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15822009
24MAF_26560356_Chip-Seq_TH1_Human2.15141714
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15043622
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.11951538
27TCF7_22412390_ChIP-Seq_EML_Mouse1.96213090
28RUNX_20019798_ChIP-Seq_JUKART_Human1.95782934
29VDR_21846776_ChIP-Seq_THP-1_Human1.93798244
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92358118
31VDR_24763502_ChIP-Seq_THP-1_Human1.91032911
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.88847389
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87504282
34UTX_26944678_Chip-Seq_JUKART_Human1.77978764
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76797967
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.74637408
37CIITA_25753668_ChIP-Seq_RAJI_Human1.74297695
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.73614245
39TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.71792040
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66434484
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66010891
42SCL_19346495_ChIP-Seq_HPC-7_Human1.64843563
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.63307727
44GATA3_27048872_Chip-Seq_THYMUS_Human1.60242896
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59768243
46TFEB_21752829_ChIP-Seq_HELA_Human1.57726742
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54774137
48KDM2B_26808549_Chip-Seq_DND41_Human1.46927560
49MAF_26560356_Chip-Seq_TH2_Human1.45574433
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45216107
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41665073
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36941345
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35986060
54GATA1_19941826_ChIP-Seq_K562_Human1.35690190
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35404857
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.34144623
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31794644
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31574960
59NCOR1_26117541_ChIP-Seq_K562_Human1.29119203
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.28464642
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.26919723
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26731722
63PU_27001747_Chip-Seq_BMDM_Mouse1.26010194
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21975165
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21322993
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19972358
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19044897
68GATA2_19941826_ChIP-Seq_K562_Human1.17746404
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16624135
70VDR_24787735_ChIP-Seq_THP-1_Human1.16398586
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16281204
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15823958
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.15397791
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11980306
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10257406
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.07927526
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07249875
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06355579
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.05696919
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05370123
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04830100
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04401257
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03817260
84GATA3_26560356_Chip-Seq_TH2_Human1.03812715
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03450745
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03450745
87FOXO3_23340844_ChIP-Seq_DLD1_Human0.99884368
88AR_21909140_ChIP-Seq_LNCAP_Human0.96990037
89ESR1_20079471_ChIP-ChIP_T-47D_Human0.96920995
90ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95902928
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94889605
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94696219
93HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94133844
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93484587
95TP63_17297297_ChIP-ChIP_HaCaT_Human0.90743242
96KDM2B_26808549_Chip-Seq_JURKAT_Human0.89788352
97SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89055537
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88798374
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86789037
100CHD1_26751641_Chip-Seq_LNCaP_Human0.86667192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.12411947
2MP0001835_abnormal_antigen_presentation3.09076457
3MP0003763_abnormal_thymus_physiology2.77488528
4MP0003300_gastrointestinal_ulcer2.73132474
5MP0010234_abnormal_vibrissa_follicle2.59525863
6MP0003724_increased_susceptibility_to2.56396337
7MP0004381_abnormal_hair_follicle2.53808583
8MP0003436_decreased_susceptibility_to2.48171670
9MP0001800_abnormal_humoral_immune2.36188863
10MP0003303_peritoneal_inflammation2.33388848
11MP0005000_abnormal_immune_tolerance2.24252240
12MP0005451_abnormal_body_composition2.21143138
13MP0008057_abnormal_DNA_replication2.19904880
14MP0002166_altered_tumor_susceptibility2.14498362
15MP0000685_abnormal_immune_system2.12235861
16MP0005387_immune_system_phenotype2.12088618
17MP0001790_abnormal_immune_system2.12088618
18MP0004808_abnormal_hematopoietic_stem2.07627139
19MP0002398_abnormal_bone_marrow2.02043698
20MP0002419_abnormal_innate_immunity2.01548643
21MP0002452_abnormal_antigen_presenting2.00324808
22MP0002420_abnormal_adaptive_immunity2.00001750
23MP0001819_abnormal_immune_cell1.97581604
24MP0010352_gastrointestinal_tract_polyps1.94891660
25MP0002723_abnormal_immune_serum1.92921726
26MP0005025_abnormal_response_to1.83923182
27MP0000703_abnormal_thymus_morphology1.78475441
28MP0004264_abnormal_extraembryonic_tissu1.75818171
29MP0002006_tumorigenesis1.73009060
30MP0003191_abnormal_cellular_cholesterol1.72999533
31MP0000716_abnormal_immune_system1.69543593
32MP0002722_abnormal_immune_system1.68990645
33MP0000689_abnormal_spleen_morphology1.66853685
34MP0009785_altered_susceptibility_to1.63057378
35MP0002405_respiratory_system_inflammati1.61256921
36MP0004947_skin_inflammation1.61141387
37MP0000015_abnormal_ear_pigmentation1.60622587
38MP0002009_preneoplasia1.59449493
39MP0005671_abnormal_response_to1.58088588
40MP0003656_abnormal_erythrocyte_physiolo1.55921742
41MP0009278_abnormal_bone_marrow1.50031153
42MP0002429_abnormal_blood_cell1.47494214
43MP0002138_abnormal_hepatobiliary_system1.46530022
44MP0003221_abnormal_cardiomyocyte_apopto1.46022790
45MP0005464_abnormal_platelet_physiology1.39368741
46MP0009697_abnormal_copulation1.38603097
47MP0005076_abnormal_cell_differentiation1.38382709
48MP0010094_abnormal_chromosome_stability1.37640242
49MP0006082_CNS_inflammation1.35764516
50MP0002877_abnormal_melanocyte_morpholog1.35763307
51MP0003091_abnormal_cell_migration1.35235558
52MP0003828_pulmonary_edema1.34846424
53MP0003172_abnormal_lysosome_physiology1.30221401
54MP0010155_abnormal_intestine_physiology1.29628225
55MP0005075_abnormal_melanosome_morpholog1.29560731
56MP0003077_abnormal_cell_cycle1.29266163
57MP0005397_hematopoietic_system_phenotyp1.25755576
58MP0001545_abnormal_hematopoietic_system1.25755576
59MP0003111_abnormal_nucleus_morphology1.25205153
60MP0008260_abnormal_autophagy1.24436588
61MP0001845_abnormal_inflammatory_respons1.23176634
62MP0003693_abnormal_embryo_hatching1.20425488
63MP0000858_altered_metastatic_potential1.20146488
64MP0005409_darkened_coat_color1.18847259
65MP0000490_abnormal_crypts_of1.15481554
66MP0002148_abnormal_hypersensitivity_rea1.14756598
67MP0009333_abnormal_splenocyte_physiolog1.14311409
68MP0003705_abnormal_hypodermis_morpholog1.13528018
69MP0003866_abnormal_defecation1.11959197
70MP0010307_abnormal_tumor_latency1.11955632
71MP0002019_abnormal_tumor_incidence1.10627613
72MP0003566_abnormal_cell_adhesion1.08239743
73MP0005310_abnormal_salivary_gland1.03434156
74MP0004957_abnormal_blastocyst_morpholog1.03196757
75MP0002132_abnormal_respiratory_system1.00901624
76MP0004233_abnormal_muscle_weight1.00513419
77MP0000465_gastrointestinal_hemorrhage0.96479920
78MP0001853_heart_inflammation0.96313978
79MP0001533_abnormal_skeleton_physiology0.94639192
80MP0005621_abnormal_cell_physiology0.92141689
81MP0000371_diluted_coat_color0.91345995
82MP0001873_stomach_inflammation0.91314777
83MP0009115_abnormal_fat_cell0.87734092
84MP0002086_abnormal_extraembryonic_tissu0.86953343
85MP0000350_abnormal_cell_proliferation0.86851770
86MP0002998_abnormal_bone_remodeling0.86117168
87MP0000313_abnormal_cell_death0.85151332
88MP0001915_intracranial_hemorrhage0.84944321
89MP0001851_eye_inflammation0.84209303
90MP0003984_embryonic_growth_retardation0.82463959
91MP0001672_abnormal_embryogenesis/_devel0.80623188
92MP0005380_embryogenesis_phenotype0.80623188
93MP0003453_abnormal_keratinocyte_physiol0.80618518
94MP0002088_abnormal_embryonic_growth/wei0.80586284
95MP0008469_abnormal_protein_level0.78708367
96MP0001730_embryonic_growth_arrest0.77545604
97MP0004883_abnormal_blood_vessel0.76992941
98MP0003448_altered_tumor_morphology0.73645837
99MP0003045_fibrosis0.72981656
100MP0002332_abnormal_exercise_endurance0.72977032

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.10586865
2Recurrent bacterial skin infections (HP:0005406)3.88483623
3Abnormal delayed hypersensitivity skin test (HP:0002963)3.84495081
4Recurrent abscess formation (HP:0002722)3.78961098
5Recurrent viral infections (HP:0004429)3.62222546
6Recurrent fungal infections (HP:0002841)3.48307015
7T lymphocytopenia (HP:0005403)3.45239243
8Panhypogammaglobulinemia (HP:0003139)3.44300460
9Abnormality of the fingertips (HP:0001211)3.36095033
10Abnormality of T cell number (HP:0011839)3.22547637
11Gastrointestinal infarctions (HP:0005244)3.09313892
12Viral hepatitis (HP:0006562)3.05089899
13Increased IgE level (HP:0003212)3.03319944
14Meningitis (HP:0001287)3.02084382
15Myositis (HP:0100614)2.98658789
16Mediastinal lymphadenopathy (HP:0100721)2.94496494
17Recurrent cutaneous fungal infections (HP:0011370)2.85927623
18Chronic mucocutaneous candidiasis (HP:0002728)2.85927623
19Spontaneous hematomas (HP:0007420)2.82991729
20Granulocytopenia (HP:0001913)2.78659940
21Abnormality of macrophages (HP:0004311)2.78604003
22Encephalitis (HP:0002383)2.76313105
23Abnormality of T cells (HP:0002843)2.75341515
24Recurrent skin infections (HP:0001581)2.70638647
25Optic neuritis (HP:0100653)2.67844964
26Retrobulbar optic neuritis (HP:0100654)2.67844964
27Colitis (HP:0002583)2.66676181
28Autoimmune hemolytic anemia (HP:0001890)2.63798415
29Acute myeloid leukemia (HP:0004808)2.63415236
30Cellulitis (HP:0100658)2.62974615
31Subacute progressive viral hepatitis (HP:0006572)2.62758468
32Elevated erythrocyte sedimentation rate (HP:0003565)2.62296448
33Orchitis (HP:0100796)2.61650007
34Fatigue (HP:0012378)2.61183237
35Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.59697961
36Obstructive lung disease (HP:0006536)2.57692973
37Chronic obstructive pulmonary disease (HP:0006510)2.57692973
38Recurrent gram-negative bacterial infections (HP:0005420)2.50701620
39Gingivitis (HP:0000230)2.47284709
40Syringomyelia (HP:0003396)2.46235428
41Spinal cord lesions (HP:0100561)2.46235428
42Vasculitis (HP:0002633)2.43749085
43Eosinophilia (HP:0001880)2.43219804
44Abnormality of T cell physiology (HP:0011840)2.42856997
45Osteomyelitis (HP:0002754)2.42642009
46Inflammation of the large intestine (HP:0002037)2.40734803
47Agammaglobulinemia (HP:0004432)2.38746914
48Lymphopenia (HP:0001888)2.37632040
49Abnormality of the peritoneum (HP:0002585)2.36430052
50Arterial thrombosis (HP:0004420)2.36199014
51Chest pain (HP:0100749)2.33232256
52Gastrointestinal inflammation (HP:0004386)2.31015254
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.27718258
54Severe combined immunodeficiency (HP:0004430)2.26144099
55Combined immunodeficiency (HP:0005387)2.25678329
56Gastrointestinal stroma tumor (HP:0100723)2.24570529
57Keratoconjunctivitis sicca (HP:0001097)2.23552915
58Leukocytosis (HP:0001974)2.23475265
59B lymphocytopenia (HP:0010976)2.19214459
60Pustule (HP:0200039)2.18813744
61Autoimmune thrombocytopenia (HP:0001973)2.15358330
62Abnormality of the columella (HP:0009929)2.15178119
63Papilledema (HP:0001085)2.15128283
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14456090
65Papillary thyroid carcinoma (HP:0002895)2.13619591
66Abnormality of B cell number (HP:0010975)2.10852307
67Acute lymphatic leukemia (HP:0006721)2.10642639
68Curly hair (HP:0002212)2.07521064
69Recurrent bronchitis (HP:0002837)2.04538652
70Slow saccadic eye movements (HP:0000514)2.03096415
71Ankyloglossia (HP:0010296)2.02605590
72Myelodysplasia (HP:0002863)2.01550071
73Lymphoma (HP:0002665)2.01153677
74Prominent nose (HP:0000448)1.97141505
75Chronic otitis media (HP:0000389)1.95918252
76Emphysema (HP:0002097)1.93718942
77Peritonitis (HP:0002586)1.93379082
78Urticaria (HP:0001025)1.91040217
79Chromsome breakage (HP:0040012)1.90785778
80Abnormality of eosinophils (HP:0001879)1.89119476
81Verrucae (HP:0200043)1.88244103
82Papilloma (HP:0012740)1.88244103
83Polycythemia (HP:0001901)1.87794102
84Myocardial infarction (HP:0001658)1.87366378
85Chronic diarrhea (HP:0002028)1.86085938
86Basal cell carcinoma (HP:0002671)1.85371700
87Abnormality of the endocardium (HP:0004306)1.85094974
88Nephroblastoma (Wilms tumor) (HP:0002667)1.83827359
89Aplasia/Hypoplasia of the thymus (HP:0010515)1.83173712
90Heterotopia (HP:0002282)1.82836361
91Keratoconjunctivitis (HP:0001096)1.82808560
92Micronodular cirrhosis (HP:0001413)1.80987869
93Amaurosis fugax (HP:0100576)1.79842572
94Deep palmar crease (HP:0006191)1.79407741
95Abnormality of the thymus (HP:0000777)1.79301917
96Anorexia (HP:0002039)1.77737446
97Abnormality of the pleura (HP:0002103)1.77206463
98Sepsis (HP:0100806)1.77105601
99Pulmonary infiltrates (HP:0002113)1.75505325
100Somatic mutation (HP:0001428)1.75323081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.51247753
2MAP3K143.27410479
3PRPF4B2.79064034
4CDK122.64529971
5MAP4K12.61655478
6MAP3K102.37405950
7MAP3K132.25412681
8IRAK42.18007648
9LATS12.09718217
10KSR22.06091932
11MARK32.04118525
12BRD42.03483878
13FGFR42.02974564
14TYK22.01318913
15JAK31.88537335
16BTK1.87703014
17PKN21.83782121
18BLK1.75670872
19SIK31.69750774
20ZAP701.62799986
21EIF2AK31.61915448
22FGFR31.52819141
23JAK11.50158238
24CSK1.49093535
25MAP3K91.45255655
26SMG11.44122847
27ERN11.40247838
28NLK1.40225044
29TAOK31.38446074
30KSR11.36390144
31EPHB11.28945943
32TRIB31.23956112
33MAP2K31.21324177
34HCK1.20622052
35MAP3K21.17188803
36TEC1.16860573
37SCYL21.16790902
38MAP3K61.14550853
39SYK1.14413542
40MAP3K11.14317186
41IKBKE1.11289507
42YES11.10291775
43CLK11.08420395
44JAK21.07563241
45STK381.04736501
46RAF11.04230091
47FGR1.02053022
48SIK21.01865229
49WNK11.01277804
50GRK60.95297698
51MARK20.92517955
52RET0.92416972
53FES0.90191178
54NEK20.89861792
55MELK0.86046049
56TXK0.85994379
57IRAK10.84134526
58CDK40.83189817
59LYN0.83105388
60ITK0.83068393
61EEF2K0.81728173
62TBK10.81575298
63CDK60.81049532
64IRAK20.76001701
65MAPK110.75279798
66MST1R0.75023605
67MAP3K80.69696098
68LCK0.69131516
69MAP3K70.68173697
70NEK90.67770722
71BMPR20.66807321
72CDC42BPA0.66008118
73STK240.59853078
74STK100.58600095
75SGK30.52569497
76TRPM70.51614392
77WEE10.51468569
78STK38L0.51340014
79MAP3K50.50457659
80ICK0.49796712
81PRKCQ0.48890008
82CDK70.48770180
83STK40.45415585
84RIPK10.44891927
85IKBKB0.44498652
86STK30.44388328
87TNK20.43747756
88PTK60.43110953
89PIM10.42732138
90CSF1R0.42488323
91PDK10.41758758
92CAMK1D0.39482110
93PDGFRB0.39027224
94MTOR0.38990437
95TGFBR20.38690468
96PDGFRA0.38327533
97IRAK30.37924775
98EGFR0.37648483
99RPS6KB20.37512436
100KIT0.35920027

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.69772374
2Acute myeloid leukemia_Homo sapiens_hsa052212.18778081
3Osteoclast differentiation_Homo sapiens_hsa043801.99450067
4Measles_Homo sapiens_hsa051621.99304493
5Chronic myeloid leukemia_Homo sapiens_hsa052201.94172207
6Non-small cell lung cancer_Homo sapiens_hsa052231.93413823
7Leishmaniasis_Homo sapiens_hsa051401.92834881
8T cell receptor signaling pathway_Homo sapiens_hsa046601.85684408
9Primary immunodeficiency_Homo sapiens_hsa053401.85628543
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.84404509
11Pancreatic cancer_Homo sapiens_hsa052121.78366248
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77924284
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74162942
14Hepatitis B_Homo sapiens_hsa051611.71466445
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.67708459
16Endometrial cancer_Homo sapiens_hsa052131.58302395
17Herpes simplex infection_Homo sapiens_hsa051681.57128171
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56524711
19Influenza A_Homo sapiens_hsa051641.53459648
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49105351
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45775851
22Prostate cancer_Homo sapiens_hsa052151.41452630
23Tuberculosis_Homo sapiens_hsa051521.40714509
24Thyroid cancer_Homo sapiens_hsa052161.40600708
25Renal cell carcinoma_Homo sapiens_hsa052111.39339529
26Hepatitis C_Homo sapiens_hsa051601.38441506
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.37268915
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34079682
29Viral carcinogenesis_Homo sapiens_hsa052031.33814226
30Toxoplasmosis_Homo sapiens_hsa051451.32399588
31Colorectal cancer_Homo sapiens_hsa052101.28482141
32Apoptosis_Homo sapiens_hsa042101.28156987
33Graft-versus-host disease_Homo sapiens_hsa053321.26900556
34Prolactin signaling pathway_Homo sapiens_hsa049171.18513711
35Other glycan degradation_Homo sapiens_hsa005111.17350614
36FoxO signaling pathway_Homo sapiens_hsa040681.14841773
37Chemokine signaling pathway_Homo sapiens_hsa040621.13740962
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10967739
39Allograft rejection_Homo sapiens_hsa053301.10605649
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10328776
41TNF signaling pathway_Homo sapiens_hsa046681.08935082
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.07786388
43Autoimmune thyroid disease_Homo sapiens_hsa053201.06961096
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05554723
45VEGF signaling pathway_Homo sapiens_hsa043701.04499363
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.03945741
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02598148
48Choline metabolism in cancer_Homo sapiens_hsa052311.02171820
49Legionellosis_Homo sapiens_hsa051341.02013699
50Viral myocarditis_Homo sapiens_hsa054161.00524767
51Shigellosis_Homo sapiens_hsa051310.99181506
52mTOR signaling pathway_Homo sapiens_hsa041500.98844990
53Malaria_Homo sapiens_hsa051440.98506103
54Inositol phosphate metabolism_Homo sapiens_hsa005620.97031629
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.96622110
56HTLV-I infection_Homo sapiens_hsa051660.96068256
57Hematopoietic cell lineage_Homo sapiens_hsa046400.95257418
58Antigen processing and presentation_Homo sapiens_hsa046120.94473918
59Staphylococcus aureus infection_Homo sapiens_hsa051500.93559844
60Epstein-Barr virus infection_Homo sapiens_hsa051690.92170658
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89879158
62Small cell lung cancer_Homo sapiens_hsa052220.89870916
63ErbB signaling pathway_Homo sapiens_hsa040120.89260067
64Glioma_Homo sapiens_hsa052140.88564270
65Dorso-ventral axis formation_Homo sapiens_hsa043200.87513720
66Platelet activation_Homo sapiens_hsa046110.86843803
67MicroRNAs in cancer_Homo sapiens_hsa052060.84051993
68p53 signaling pathway_Homo sapiens_hsa041150.83629717
69Cell cycle_Homo sapiens_hsa041100.81349713
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80450872
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77654472
72mRNA surveillance pathway_Homo sapiens_hsa030150.77480632
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75965796
74Bladder cancer_Homo sapiens_hsa052190.75774393
75Adherens junction_Homo sapiens_hsa045200.73912822
76HIF-1 signaling pathway_Homo sapiens_hsa040660.71676933
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.70719669
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.67968017
79Insulin signaling pathway_Homo sapiens_hsa049100.67656443
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.66604282
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61016375
82Notch signaling pathway_Homo sapiens_hsa043300.60632112
83Insulin resistance_Homo sapiens_hsa049310.60582376
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59426689
85Proteoglycans in cancer_Homo sapiens_hsa052050.58647676
86Endocytosis_Homo sapiens_hsa041440.57286580
87Estrogen signaling pathway_Homo sapiens_hsa049150.54491195
88GnRH signaling pathway_Homo sapiens_hsa049120.54436416
89Type I diabetes mellitus_Homo sapiens_hsa049400.52055043
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51023638
91Pathways in cancer_Homo sapiens_hsa052000.50019371
92Salmonella infection_Homo sapiens_hsa051320.49132371
93African trypanosomiasis_Homo sapiens_hsa051430.48797726
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.48100006
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48052564
96Melanoma_Homo sapiens_hsa052180.47530519
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46735893
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46633664
99Phagosome_Homo sapiens_hsa041450.46009368
100MAPK signaling pathway_Homo sapiens_hsa040100.45033928

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