ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	4.31132350
2	pyrimidine nucleobase catabolic process (GO:0006208)	3.82732063
3	chromatin remodeling at centromere (GO:0031055)	3.66804644
4	CENP-A containing nucleosome assembly (GO:0034080)	3.57327126
5	negative regulation of DNA recombination (GO:0045910)	3.56761180
6	cullin deneddylation (GO:0010388)	3.40198370
7	regulation of helicase activity (GO:0051095)	3.32944159
8	regulation of meiosis I (GO:0060631)	3.31399590
9	presynaptic membrane assembly (GO:0097105)	3.31379005
10	proteasome assembly (GO:0043248)	3.27579073
11	DNA ligation (GO:0006266)	3.26344339
12	positive regulation of mitochondrial fission (GO:0090141)	3.22502154
13	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.18981418
14	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.18981418
15	histone exchange (GO:0043486)	3.15220565
16	synapsis (GO:0007129)	3.13882295
17	organelle disassembly (GO:1903008)	3.05848676
18	DNA damage response, detection of DNA damage (GO:0042769)	3.04920537
19	resolution of meiotic recombination intermediates (GO:0000712)	3.03187972
20	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.99325146
21	response to pheromone (GO:0019236)	2.98810146
22	DNA replication checkpoint (GO:0000076)	2.98432165
23	nucleobase catabolic process (GO:0046113)	2.97636263
24	neural tube formation (GO:0001841)	2.97205585
25	protein deneddylation (GO:0000338)	2.93702930
26	protein neddylation (GO:0045116)	2.90727747
27	establishment of integrated proviral latency (GO:0075713)	2.89740406
28	histone H2A acetylation (GO:0043968)	2.87305169
29	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.86316467
30	water-soluble vitamin biosynthetic process (GO:0042364)	2.84161176
31	DNA replication-independent nucleosome assembly (GO:0006336)	2.83352718
32	DNA replication-independent nucleosome organization (GO:0034724)	2.83352718
33	kinetochore assembly (GO:0051382)	2.83112314
34	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.80649805
35	presynaptic membrane organization (GO:0097090)	2.78425168
36	non-recombinational repair (GO:0000726)	2.77629553
37	double-strand break repair via nonhomologous end joining (GO:0006303)	2.77629553
38	intraciliary transport (GO:0042073)	2.76404705
39	DNA catabolic process, exonucleolytic (GO:0000738)	2.76389262
40	microtubule depolymerization (GO:0007019)	2.75618573
41	ribonucleoprotein complex disassembly (GO:0032988)	2.74713343
42	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.72668671
43	DNA integration (GO:0015074)	2.71202625
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.67386727
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.67386727
46	protein K6-linked ubiquitination (GO:0085020)	2.65512457
47	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.64865979
48	nonmotile primary cilium assembly (GO:0035058)	2.64217782
49	mitotic spindle checkpoint (GO:0071174)	2.63837015
50	protein-cofactor linkage (GO:0018065)	2.63702970
51	replication fork processing (GO:0031297)	2.63435955
52	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.62759269
53	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.62759269
54	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.60501633
55	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.60501633
56	isotype switching (GO:0045190)	2.60501633
57	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.60358879
58	kinetochore organization (GO:0051383)	2.60239923
59	protein K11-linked ubiquitination (GO:0070979)	2.59841721
60	ubiquinone metabolic process (GO:0006743)	2.58821267
61	neuron cell-cell adhesion (GO:0007158)	2.58071032
62	spindle checkpoint (GO:0031577)	2.56795914
63	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.55703046
64	negative regulation of sister chromatid segregation (GO:0033046)	2.55703046
65	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.55703046
66	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.55703046
67	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.55703046
68	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.53985444
69	regulation of mitotic spindle checkpoint (GO:1903504)	2.53985444
70	histone mRNA metabolic process (GO:0008334)	2.53080931
71	regulation of cilium movement (GO:0003352)	2.50650104
72	protein localization to cilium (GO:0061512)	2.49644760
73	negative regulation of chromosome segregation (GO:0051985)	2.49356762
74	L-methionine salvage (GO:0071267)	2.48875573
75	L-methionine biosynthetic process (GO:0071265)	2.48875573
76	amino acid salvage (GO:0043102)	2.48875573
77	amino acid activation (GO:0043038)	2.48415317
78	tRNA aminoacylation (GO:0043039)	2.48415317
79	mitochondrial RNA metabolic process (GO:0000959)	2.47745443
80	mitochondrial respiratory chain complex assembly (GO:0033108)	2.47502056
81	purine nucleobase biosynthetic process (GO:0009113)	2.46055445
82	tRNA aminoacylation for protein translation (GO:0006418)	2.44372313
83	mitotic spindle assembly checkpoint (GO:0007094)	2.44247663
84	postreplication repair (GO:0006301)	2.44107638
85	spindle assembly checkpoint (GO:0071173)	2.43675280
86	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.42793956
87	recombinational repair (GO:0000725)	2.42598360
88	sequestering of actin monomers (GO:0042989)	2.42034067
89	respiratory chain complex IV assembly (GO:0008535)	2.41824932
90	peptidyl-histidine modification (GO:0018202)	2.41811693
91	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.41545898
92	intra-S DNA damage checkpoint (GO:0031573)	2.41373815
93	protein complex biogenesis (GO:0070271)	2.40828586
94	regulation of mitochondrial translation (GO:0070129)	2.39871873
95	mismatch repair (GO:0006298)	2.39849796
96	chaperone-mediated protein transport (GO:0072321)	2.38210444
97	reciprocal meiotic recombination (GO:0007131)	2.38094557
98	reciprocal DNA recombination (GO:0035825)	2.38094557
99	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.37650341
100	ATP synthesis coupled proton transport (GO:0015986)	2.37650341

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.55842593
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.05094852
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.03716893
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.93311007
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.88789291
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.85881793
7	E2F7_22180533_ChIP-Seq_HELA_Human	2.71149395
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.64238663
9	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.63169472
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.59948023
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.49677238
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.45434824
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.42143331
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.40635621
15	FUS_26573619_Chip-Seq_HEK293_Human	2.40321709
16	EWS_26573619_Chip-Seq_HEK293_Human	2.36820869
17	VDR_22108803_ChIP-Seq_LS180_Human	2.29404117
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.23342856
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.19166443
20	GBX2_23144817_ChIP-Seq_PC3_Human	2.18887039
21	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.14699872
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.12336397
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.04550186
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.03792146
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.02575602
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.95049789
27	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.90410248
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.79196345
29	P300_19829295_ChIP-Seq_ESCs_Human	1.75071131
30	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.73484259
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71543413
32	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.70998036
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.70786206
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.68612334
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66427743
36	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.62085562
37	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.60850980
38	FOXP3_21729870_ChIP-Seq_TREG_Human	1.59220242
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.58565357
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56800265
41	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.54120940
42	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.51964596
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.48170713
44	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.45279106
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.43036138
46	EZH2_22144423_ChIP-Seq_EOC_Human	1.38825018
47	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.37918311
48	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.37416888
49	DCP1A_22483619_ChIP-Seq_HELA_Human	1.31892069
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28135803
51	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.27526311
52	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.27253609
53	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.26855574
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.26572786
55	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25917104
56	GABP_19822575_ChIP-Seq_HepG2_Human	1.23422571
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22662641
58	TTF2_22483619_ChIP-Seq_HELA_Human	1.22300825
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.21940573
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.21150301
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21150301
62	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.19753167
63	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.19187405
64	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.19045716
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18385961
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17439874
67	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17115033
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16543252
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.13505600
70	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.12495191
71	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12126357
72	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.10267444
73	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.08760786
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08232030
75	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.07028405
76	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.05059105
77	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.04790838
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04151319
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.04083706
80	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.02671150
81	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.02550471
82	TP53_22573176_ChIP-Seq_HFKS_Human	1.02030366
83	SMAD4_21799915_ChIP-Seq_A2780_Human	1.01293901
84	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.01062789
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00719867
86	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.00258820
87	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98240260
88	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96911366
89	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.95616570
90	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.95346490
91	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95147929
92	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.94719504
93	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.94120571
94	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.93994476
95	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.93465175
96	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.92402316
97	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.92300429
98	NANOG_19829295_ChIP-Seq_ESCs_Human	0.92172492
99	SOX2_19829295_ChIP-Seq_ESCs_Human	0.92172492
100	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.92007102

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	3.00835886
2	MP0001529_abnormal_vocalization	2.95635905
3	MP0003880_abnormal_central_pattern	2.93929698
4	MP0008877_abnormal_DNA_methylation	2.91168633
5	MP0002102_abnormal_ear_morphology	2.61678225
6	MP0010094_abnormal_chromosome_stability	2.51797040
7	MP0005394_taste/olfaction_phenotype	2.49171802
8	MP0005499_abnormal_olfactory_system	2.49171802
9	MP0008789_abnormal_olfactory_epithelium	2.43849090
10	MP0003890_abnormal_embryonic-extraembry	2.35968925
11	MP0006292_abnormal_olfactory_placode	2.24708041
12	MP0001984_abnormal_olfaction	2.13315600
13	MP0008995_early_reproductive_senescence	2.00588412
14	MP0003693_abnormal_embryo_hatching	1.90718544
15	MP0001188_hyperpigmentation	1.90122578
16	MP0003121_genomic_imprinting	1.88838524
17	MP0005645_abnormal_hypothalamus_physiol	1.87899837
18	MP0003787_abnormal_imprinting	1.86330807
19	MP0006072_abnormal_retinal_apoptosis	1.77708623
20	MP0005187_abnormal_penis_morphology	1.75123238
21	MP0006276_abnormal_autonomic_nervous	1.72707792
22	MP0002938_white_spotting	1.71170765
23	MP0000778_abnormal_nervous_system	1.69796811
24	MP0004957_abnormal_blastocyst_morpholog	1.69710158
25	MP0003122_maternal_imprinting	1.68610885
26	MP0002822_catalepsy	1.68279555
27	MP0001293_anophthalmia	1.65183179
28	MP0003718_maternal_effect	1.63585336
29	MP0008932_abnormal_embryonic_tissue	1.60894787
30	MP0002751_abnormal_autonomic_nervous	1.56992254
31	MP0003136_yellow_coat_color	1.56296150
32	MP0005253_abnormal_eye_physiology	1.50404729
33	MP0002736_abnormal_nociception_after	1.45709353
34	MP0000647_abnormal_sebaceous_gland	1.45127891
35	MP0004147_increased_porphyrin_level	1.44723743
36	MP0006035_abnormal_mitochondrial_morpho	1.38908097
37	MP0001968_abnormal_touch/_nociception	1.38868100
38	MP0002234_abnormal_pharynx_morphology	1.38707865
39	MP0003567_abnormal_fetal_cardiomyocyte	1.37622772
40	MP0002233_abnormal_nose_morphology	1.36351442
41	MP0009046_muscle_twitch	1.35331210
42	MP0002638_abnormal_pupillary_reflex	1.34110736
43	MP0003786_premature_aging	1.32468052
44	MP0002160_abnormal_reproductive_system	1.32001538
45	MP0000631_abnormal_neuroendocrine_gland	1.31822782
46	MP0004133_heterotaxia	1.31170351
47	MP0003937_abnormal_limbs/digits/tail_de	1.30015393
48	MP0003111_abnormal_nucleus_morphology	1.29366641
49	MP0001986_abnormal_taste_sensitivity	1.26686466
50	MP0003077_abnormal_cell_cycle	1.25956679
51	MP0004270_analgesia	1.24983016
52	MP0005551_abnormal_eye_electrophysiolog	1.21984277
53	MP0009697_abnormal_copulation	1.20370550
54	MP0002653_abnormal_ependyma_morphology	1.20063801
55	MP0003221_abnormal_cardiomyocyte_apopto	1.18769932
56	MP0005075_abnormal_melanosome_morpholog	1.16344176
57	MP0003119_abnormal_digestive_system	1.15444833
58	MP0001286_abnormal_eye_development	1.11505801
59	MP0002210_abnormal_sex_determination	1.11322686
60	MP0002272_abnormal_nervous_system	1.10374504
61	MP0001486_abnormal_startle_reflex	1.09607485
62	MP0001929_abnormal_gametogenesis	1.09021984
63	MP0004142_abnormal_muscle_tone	1.04687816
64	MP0002734_abnormal_mechanical_nocicepti	1.03436657
65	MP0009745_abnormal_behavioral_response	1.02912863
66	MP0001485_abnormal_pinna_reflex	1.02322867
67	MP0000372_irregular_coat_pigmentation	1.01918760
68	MP0000049_abnormal_middle_ear	1.01809822
69	MP0002557_abnormal_social/conspecific_i	1.00352228
70	MP0008007_abnormal_cellular_replicative	0.99609213
71	MP0000653_abnormal_sex_gland	0.98855650
72	MP0003698_abnormal_male_reproductive	0.97900745
73	MP0005391_vision/eye_phenotype	0.97498959
74	MP0003861_abnormal_nervous_system	0.96548419
75	MP0002184_abnormal_innervation	0.96469458
76	MP0001145_abnormal_male_reproductive	0.95586760
77	MP0003635_abnormal_synaptic_transmissio	0.93431023
78	MP0002752_abnormal_somatic_nervous	0.91762062
79	MP0000955_abnormal_spinal_cord	0.90943389
80	MP0002735_abnormal_chemical_nociception	0.90405432
81	MP0005084_abnormal_gallbladder_morpholo	0.90114093
82	MP0002572_abnormal_emotion/affect_behav	0.87238175
83	MP0002095_abnormal_skin_pigmentation	0.86890659
84	MP0005423_abnormal_somatic_nervous	0.86513879
85	MP0001177_atelectasis	0.84885132
86	MP0002067_abnormal_sensory_capabilities	0.84402885
87	MP0008057_abnormal_DNA_replication	0.83483109
88	MP0004924_abnormal_behavior	0.83035935
89	MP0005386_behavior/neurological_phenoty	0.83035935
90	MP0004811_abnormal_neuron_physiology	0.82729862
91	MP0002090_abnormal_vision	0.82679380
92	MP0005389_reproductive_system_phenotype	0.82026825
93	MP0000569_abnormal_digit_pigmentation	0.81857925
94	MP0002063_abnormal_learning/memory/cond	0.80339910
95	MP0005248_abnormal_Harderian_gland	0.79914209
96	MP0001119_abnormal_female_reproductive	0.79207555
97	MP0006036_abnormal_mitochondrial_physio	0.79043443
98	MP0002882_abnormal_neuron_morphology	0.79042656
99	MP0002084_abnormal_developmental_patter	0.78628410
100	MP0004197_abnormal_fetal_growth/weight/	0.77142494

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	3.46665782
2	Colon cancer (HP:0003003)	3.30179204
3	Methylmalonic acidemia (HP:0002912)	2.97073527
4	Hyperglycinemia (HP:0002154)	2.90676232
5	Medial flaring of the eyebrow (HP:0010747)	2.86100868
6	Gait imbalance (HP:0002141)	2.78503410
7	Cortical dysplasia (HP:0002539)	2.77437061
8	Congenital primary aphakia (HP:0007707)	2.76250950
9	Nephrogenic diabetes insipidus (HP:0009806)	2.70955439
10	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.66998590
11	Meckel diverticulum (HP:0002245)	2.63147962
12	Abnormality of chromosome stability (HP:0003220)	2.58514090
13	Pancreatic fibrosis (HP:0100732)	2.56058008
14	True hermaphroditism (HP:0010459)	2.56033257
15	Acute necrotizing encephalopathy (HP:0006965)	2.52309152
16	Genital tract atresia (HP:0001827)	2.52162757
17	Abnormality of the ileum (HP:0001549)	2.51934549
18	Acute encephalopathy (HP:0006846)	2.50905423
19	Medulloblastoma (HP:0002885)	2.50589193
20	Pancreatic cysts (HP:0001737)	2.44222778
21	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.41396257
22	Septo-optic dysplasia (HP:0100842)	2.38705526
23	Vaginal atresia (HP:0000148)	2.38684551
24	Increased hepatocellular lipid droplets (HP:0006565)	2.35631288
25	Progressive macrocephaly (HP:0004481)	2.28070626
26	Chronic hepatic failure (HP:0100626)	2.25417132
27	Methylmalonic aciduria (HP:0012120)	2.25191506
28	Abnormal mitochondria in muscle tissue (HP:0008316)	2.24126321
29	Chromsome breakage (HP:0040012)	2.22860613
30	3-Methylglutaconic aciduria (HP:0003535)	2.18402653
31	Abnormality of serum amino acid levels (HP:0003112)	2.17196509
32	Pendular nystagmus (HP:0012043)	2.16905961
33	Lipid accumulation in hepatocytes (HP:0006561)	2.16793031
34	Increased CSF lactate (HP:0002490)	2.16359109
35	Abnormality of the preputium (HP:0100587)	2.15121092
36	Abnormality of serine family amino acid metabolism (HP:0010894)	2.14948293
37	Abnormality of glycine metabolism (HP:0010895)	2.14948293
38	Nephronophthisis (HP:0000090)	2.13371902
39	Abnormal lung lobation (HP:0002101)	2.11682915
40	Intestinal atresia (HP:0011100)	2.11642848
41	Hyperglycinuria (HP:0003108)	2.11430054
42	Duodenal stenosis (HP:0100867)	2.07213751
43	Small intestinal stenosis (HP:0012848)	2.07213751
44	Mitochondrial inheritance (HP:0001427)	2.06130098
45	Molar tooth sign on MRI (HP:0002419)	2.05769515
46	Abnormality of midbrain morphology (HP:0002418)	2.05769515
47	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.03630289
48	Ependymoma (HP:0002888)	2.03105807
49	Short tibia (HP:0005736)	2.00274727
50	Renal cortical cysts (HP:0000803)	1.98922439
51	Triphalangeal thumb (HP:0001199)	1.98515381
52	Drooling (HP:0002307)	1.98413020
53	Glioma (HP:0009733)	1.98158090
54	Poor coordination (HP:0002370)	1.97778405
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.97259889
56	Abnormality of alanine metabolism (HP:0010916)	1.97259889
57	Hyperalaninemia (HP:0003348)	1.97259889
58	Sloping forehead (HP:0000340)	1.94402781
59	Absent eyebrow (HP:0002223)	1.92442511
60	Abnormality of the duodenum (HP:0002246)	1.92210876
61	Amyotrophic lateral sclerosis (HP:0007354)	1.89667386
62	Astrocytoma (HP:0009592)	1.88632039
63	Abnormality of the astrocytes (HP:0100707)	1.88632039
64	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.86825574
65	Postaxial foot polydactyly (HP:0001830)	1.86272409
66	Progressive inability to walk (HP:0002505)	1.85787034
67	Postaxial hand polydactyly (HP:0001162)	1.85186506
68	Specific learning disability (HP:0001328)	1.84895121
69	Astigmatism (HP:0000483)	1.82753852
70	Retinal dysplasia (HP:0007973)	1.82134178
71	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.81149471
72	Oligodactyly (hands) (HP:0001180)	1.80813055
73	Lissencephaly (HP:0001339)	1.80389577
74	Hepatocellular necrosis (HP:0001404)	1.79945965
75	Polyphagia (HP:0002591)	1.78166692
76	Hepatoblastoma (HP:0002884)	1.77392733
77	Broad foot (HP:0001769)	1.76424674
78	Abnormality of homocysteine metabolism (HP:0010919)	1.74989575
79	Homocystinuria (HP:0002156)	1.74989575
80	Abnormality of vitamin B metabolism (HP:0004340)	1.74967876
81	Increased serum lactate (HP:0002151)	1.74700334
82	Optic nerve hypoplasia (HP:0000609)	1.73303381
83	Excessive salivation (HP:0003781)	1.73080063
84	Volvulus (HP:0002580)	1.72621685
85	Hepatic necrosis (HP:0002605)	1.72299421
86	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.71912491
87	Hyperventilation (HP:0002883)	1.71528240
88	Abnormality of the carotid arteries (HP:0005344)	1.71084224
89	Cerebral edema (HP:0002181)	1.69893847
90	Abnormality of the renal medulla (HP:0100957)	1.69598328
91	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.69208155
92	Supernumerary spleens (HP:0009799)	1.66713156
93	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.66465273
94	Increased serum pyruvate (HP:0003542)	1.65214677
95	Abolished electroretinogram (ERG) (HP:0000550)	1.64035714
96	Anencephaly (HP:0002323)	1.63657569
97	Patellar aplasia (HP:0006443)	1.63147602
98	Broad-based gait (HP:0002136)	1.63074954
99	Absent septum pellucidum (HP:0001331)	1.62176109
100	Decreased testicular size (HP:0008734)	1.61325603

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	3.52018721
2	TRIM28	3.06442790
3	SRPK1	2.98062184
4	BCR	2.90465171
5	MAP3K4	2.59905655
6	MAP4K2	2.11847490
7	MAP2K7	2.00560961
8	ERBB3	2.00286248
9	CASK	1.96389034
10	TSSK6	1.91229185
11	EIF2AK3	1.89696371
12	ZAK	1.86637249
13	WEE1	1.83629607
14	PLK4	1.81930275
15	MKNK2	1.81164451
16	MKNK1	1.78692142
17	FRK	1.72406282
18	VRK1	1.71805202
19	MARK1	1.70159383
20	NUAK1	1.67550580
21	CDC7	1.65788048
22	PLK3	1.65252231
23	DYRK2	1.64525414
24	BUB1	1.63362121
25	MAPK13	1.63269582
26	CSNK1G2	1.62966681
27	BMPR1B	1.62293910
28	NEK1	1.62208842
29	CDK19	1.59026728
30	CSNK1G3	1.58257453
31	CSNK1G1	1.56315846
32	CSNK1A1L	1.52833058
33	PINK1	1.43981595
34	PLK2	1.40035942
35	DYRK3	1.38637719
36	EPHA4	1.35470683
37	TTK	1.33166777
38	PBK	1.28272154
39	PLK1	1.22438367
40	BRSK2	1.20997472
41	TNIK	1.20764422
42	BCKDK	1.19676054
43	RPS6KA4	1.16920112
44	STK16	1.13878311
45	CCNB1	1.13068623
46	VRK2	1.07546892
47	ACVR1B	1.06757041
48	MINK1	0.98936634
49	NTRK2	0.95161379
50	GRK1	0.91310094
51	OXSR1	0.88381521
52	SIK3	0.87077432
53	ATR	0.85448931
54	MAP2K4	0.83523288
55	STK38L	0.81803378
56	ADRBK2	0.80928559
57	TAF1	0.76707379
58	NME1	0.73766776
59	EIF2AK1	0.73175789
60	PNCK	0.71218606
61	FLT3	0.70081579
62	PRKCG	0.69907712
63	ATM	0.65831486
64	MST4	0.65153769
65	PRKCE	0.65026384
66	CDK3	0.61535025
67	INSRR	0.60241721
68	AURKB	0.57278575
69	PAK3	0.56546129
70	PASK	0.55975672
71	NTRK3	0.54184732
72	KSR1	0.53918914
73	FGFR2	0.53656280
74	EIF2AK2	0.53096151
75	BRSK1	0.52911117
76	MAP3K12	0.52892798
77	DYRK1A	0.52118154
78	RPS6KA5	0.50322471
79	STK39	0.48899171
80	CSNK1D	0.47524240
81	MAP3K5	0.45522806
82	FER	0.43680380
83	CAMK2A	0.42430197
84	OBSCN	0.42426584
85	CHEK2	0.42303501
86	CSNK2A1	0.42195187
87	BRD4	0.42061090
88	PIK3CA	0.40784281
89	CDK14	0.39750561
90	CSNK1E	0.39310221
91	CHEK1	0.38773500
92	CSNK1A1	0.36666391
93	TGFBR1	0.35647337
94	WNK4	0.34455560
95	AURKA	0.34217021
96	CLK1	0.34090864
97	CSNK2A2	0.33488102
98	CDK1	0.33229696
99	CDK18	0.33169453
100	PRKDC	0.32619404

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	2.99295960
2	Mismatch repair_Homo sapiens_hsa03430	2.95808964
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.71550635
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.51201144
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.50636108
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.42099589
7	Homologous recombination_Homo sapiens_hsa03440	2.39921650
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.35023295
9	Parkinsons disease_Homo sapiens_hsa05012	2.31679639
10	Basal transcription factors_Homo sapiens_hsa03022	2.28042817
11	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.27554011
12	Proteasome_Homo sapiens_hsa03050	2.21907211
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.14336333
14	RNA polymerase_Homo sapiens_hsa03020	2.13376522
15	Nicotine addiction_Homo sapiens_hsa05033	2.07007878
16	Steroid biosynthesis_Homo sapiens_hsa00100	2.00326902
17	Propanoate metabolism_Homo sapiens_hsa00640	1.99896516
18	RNA transport_Homo sapiens_hsa03013	1.93640784
19	DNA replication_Homo sapiens_hsa03030	1.92473323
20	RNA degradation_Homo sapiens_hsa03018	1.89141792
21	Spliceosome_Homo sapiens_hsa03040	1.87285377
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79263081
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.75252441
24	Huntingtons disease_Homo sapiens_hsa05016	1.66731178
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.57915547
26	Butanoate metabolism_Homo sapiens_hsa00650	1.56653431
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.55801111
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.55664933
29	Base excision repair_Homo sapiens_hsa03410	1.55432630
30	Phototransduction_Homo sapiens_hsa04744	1.40251026
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39797354
32	One carbon pool by folate_Homo sapiens_hsa00670	1.35691041
33	Cell cycle_Homo sapiens_hsa04110	1.32857991
34	Alzheimers disease_Homo sapiens_hsa05010	1.32720359
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.30543051
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.30345982
37	Fatty acid elongation_Homo sapiens_hsa00062	1.22417949
38	Taste transduction_Homo sapiens_hsa04742	1.17545979
39	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.15667934
40	Oocyte meiosis_Homo sapiens_hsa04114	1.14847368
41	Ribosome_Homo sapiens_hsa03010	1.12802533
42	GABAergic synapse_Homo sapiens_hsa04727	1.12442107
43	Peroxisome_Homo sapiens_hsa04146	1.08971495
44	Regulation of autophagy_Homo sapiens_hsa04140	1.07688792
45	mRNA surveillance pathway_Homo sapiens_hsa03015	1.02189047
46	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.01206750
47	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00347056
48	Pyruvate metabolism_Homo sapiens_hsa00620	0.94166046
49	Purine metabolism_Homo sapiens_hsa00230	0.91600071
50	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.90581256
51	Selenocompound metabolism_Homo sapiens_hsa00450	0.89379403
52	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.87550587
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85783684
54	Folate biosynthesis_Homo sapiens_hsa00790	0.84350173
55	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.82805431
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.79739969
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77588718
58	Cardiac muscle contraction_Homo sapiens_hsa04260	0.77247564
59	p53 signaling pathway_Homo sapiens_hsa04115	0.75257848
60	Morphine addiction_Homo sapiens_hsa05032	0.75210411
61	Olfactory transduction_Homo sapiens_hsa04740	0.74547088
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73881603
63	Metabolic pathways_Homo sapiens_hsa01100	0.68837959
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63762020
65	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.61839124
66	Carbon metabolism_Homo sapiens_hsa01200	0.61342406
67	Caffeine metabolism_Homo sapiens_hsa00232	0.59466868
68	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.59055411
69	Alcoholism_Homo sapiens_hsa05034	0.57530672
70	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.56882267
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.53349438
72	Dopaminergic synapse_Homo sapiens_hsa04728	0.52548826
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.51426628
74	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.50452515
75	Glutamatergic synapse_Homo sapiens_hsa04724	0.50197709
76	Nitrogen metabolism_Homo sapiens_hsa00910	0.49932940
77	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.49253801
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.48889890
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48735798
80	Circadian entrainment_Homo sapiens_hsa04713	0.47590934
81	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46464828
82	Glutathione metabolism_Homo sapiens_hsa00480	0.43419703
83	Circadian rhythm_Homo sapiens_hsa04710	0.43237352
84	Basal cell carcinoma_Homo sapiens_hsa05217	0.42266124
85	Serotonergic synapse_Homo sapiens_hsa04726	0.41091079
86	Tryptophan metabolism_Homo sapiens_hsa00380	0.40379484
87	Linoleic acid metabolism_Homo sapiens_hsa00591	0.39798861
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.38635735
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.38522283
90	Wnt signaling pathway_Homo sapiens_hsa04310	0.36295572
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36170434
92	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.35633611
93	Amphetamine addiction_Homo sapiens_hsa05031	0.34276031
94	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33381862
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32755820
96	Retinol metabolism_Homo sapiens_hsa00830	0.29713119
97	Ether lipid metabolism_Homo sapiens_hsa00565	0.28946973
98	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.28730666
99	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27333298
100	Cocaine addiction_Homo sapiens_hsa05030	0.25923532

ZNF138

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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