ZNF14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain is known to be involved in the transcriptional repression of a number of zinc finger proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)4.46338217
2microtubule depolymerization (GO:0007019)4.22221970
3regulation of sarcomere organization (GO:0060297)4.21663573
4neural tube formation (GO:0001841)4.14506667
5neuron cell-cell adhesion (GO:0007158)3.78756979
6positive regulation of oligodendrocyte differentiation (GO:0048714)3.72140105
7pyrimidine nucleobase catabolic process (GO:0006208)3.65215846
8behavioral response to ethanol (GO:0048149)3.62296229
9limb bud formation (GO:0060174)3.59988920
10response to pheromone (GO:0019236)3.56223034
11regulation of telomere maintenance (GO:0032204)3.48825926
12presynaptic membrane assembly (GO:0097105)3.47169945
13fucose catabolic process (GO:0019317)3.46097723
14L-fucose metabolic process (GO:0042354)3.46097723
15L-fucose catabolic process (GO:0042355)3.46097723
16neurotransmitter-gated ion channel clustering (GO:0072578)3.38101215
17axoneme assembly (GO:0035082)3.34588946
18protein polyglutamylation (GO:0018095)3.33882193
19sympathetic nervous system development (GO:0048485)3.31280656
20negative regulation of translation, ncRNA-mediated (GO:0040033)3.28488017
21regulation of translation, ncRNA-mediated (GO:0045974)3.28488017
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.28488017
23indolalkylamine metabolic process (GO:0006586)3.24432679
24negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.22972756
25postsynaptic membrane organization (GO:0001941)3.22917367
26intraciliary transport (GO:0042073)3.21251185
27epithelial cilium movement (GO:0003351)3.17256662
28nucleobase catabolic process (GO:0046113)3.10883091
29somite development (GO:0061053)3.10660672
30kynurenine metabolic process (GO:0070189)3.10476964
31DNA double-strand break processing (GO:0000729)3.09294194
32DNA damage response, detection of DNA damage (GO:0042769)3.06586207
33regulation of penile erection (GO:0060405)3.05929193
34regulation of timing of cell differentiation (GO:0048505)3.05028327
35regulation of transmission of nerve impulse (GO:0051969)3.04931523
36keratinocyte development (GO:0003334)3.04393928
37histone H2A acetylation (GO:0043968)3.02118878
38regulation of meiosis I (GO:0060631)3.00531815
39positive regulation of T cell cytokine production (GO:0002726)2.96633804
40resolution of meiotic recombination intermediates (GO:0000712)2.94332339
41central nervous system projection neuron axonogenesis (GO:0021952)2.87900400
42monoubiquitinated protein deubiquitination (GO:0035520)2.87569238
43presynaptic membrane organization (GO:0097090)2.87371521
44water-soluble vitamin biosynthetic process (GO:0042364)2.86820574
45regulation of collateral sprouting (GO:0048670)2.85654299
46glial cell proliferation (GO:0014009)2.84080520
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84067971
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84067971
49gamma-aminobutyric acid transport (GO:0015812)2.82283593
50piRNA metabolic process (GO:0034587)2.81511708
51regulation of development, heterochronic (GO:0040034)2.77843787
52somatic hypermutation of immunoglobulin genes (GO:0016446)2.77415715
53somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77415715
54respiratory chain complex IV assembly (GO:0008535)2.75579647
55inositol phosphate catabolic process (GO:0071545)2.75222682
56glycosphingolipid biosynthetic process (GO:0006688)2.73784008
57protein K11-linked deubiquitination (GO:0035871)2.71842578
58negative regulation of telomere maintenance (GO:0032205)2.71791658
59protein localization to cilium (GO:0061512)2.70981303
60behavioral response to nicotine (GO:0035095)2.69808827
61negative regulation of DNA-dependent DNA replication (GO:2000104)2.68639530
62centriole replication (GO:0007099)2.66985410
63retinal ganglion cell axon guidance (GO:0031290)2.65843414
64cell wall macromolecule metabolic process (GO:0044036)2.63688297
65cell wall macromolecule catabolic process (GO:0016998)2.62397164
66prenylation (GO:0097354)2.61168508
67protein prenylation (GO:0018342)2.61168508
68metallo-sulfur cluster assembly (GO:0031163)2.60662767
69iron-sulfur cluster assembly (GO:0016226)2.60662767
70regulation of axon regeneration (GO:0048679)2.59197384
71regulation of neuron projection regeneration (GO:0070570)2.59197384
72dentate gyrus development (GO:0021542)2.57254598
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57151131
74positive regulation of protein homodimerization activity (GO:0090073)2.56917380
75RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.56486435
76central nervous system neuron axonogenesis (GO:0021955)2.55309507
77fucosylation (GO:0036065)2.54273438
78seminiferous tubule development (GO:0072520)2.53564634
79positive regulation of T-helper 1 type immune response (GO:0002827)2.53256830
80tryptophan metabolic process (GO:0006568)2.53062001
81regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.52842458
82kidney morphogenesis (GO:0060993)2.52727672
83regulation of cilium movement (GO:0003352)2.52666281
84cilium movement (GO:0003341)2.52590793
85DNA deamination (GO:0045006)2.52543489
86regulation of feeding behavior (GO:0060259)2.51803576
87cilium morphogenesis (GO:0060271)2.50547159
88negative regulation of T cell mediated immunity (GO:0002710)2.50454651
89positive regulation of T cell chemotaxis (GO:0010820)2.49850550
90regulation of T cell chemotaxis (GO:0010819)2.49850550
91microtubule polymerization or depolymerization (GO:0031109)2.49577559
92positive regulation of mitochondrial fission (GO:0090141)2.48753025
93positive regulation of amino acid transport (GO:0051957)2.48121954
94replication fork processing (GO:0031297)2.47970471
95nucleotide transmembrane transport (GO:1901679)2.46820013
96cerebral cortex radially oriented cell migration (GO:0021799)2.45720095
97calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.45643777
98cilium organization (GO:0044782)2.43622000
99regulation of nuclear cell cycle DNA replication (GO:0033262)2.43458569
100detection of light stimulus involved in sensory perception (GO:0050962)2.43157719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.90827888
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.79923130
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.06602643
4VDR_22108803_ChIP-Seq_LS180_Human2.98175676
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.93732768
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75949804
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.63933717
8GBX2_23144817_ChIP-Seq_PC3_Human2.60920148
9FUS_26573619_Chip-Seq_HEK293_Human2.60401971
10IGF1R_20145208_ChIP-Seq_DFB_Human2.41463738
11TAF15_26573619_Chip-Seq_HEK293_Human2.40869360
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37884162
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36719068
14EWS_26573619_Chip-Seq_HEK293_Human2.30056124
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26510743
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19499892
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12826204
18EZH2_22144423_ChIP-Seq_EOC_Human2.09088368
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.05245996
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05226275
21P300_19829295_ChIP-Seq_ESCs_Human2.02381265
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01336566
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94604379
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94403890
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.88479460
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85312779
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.83719659
28* NOTCH1_21737748_ChIP-Seq_TLL_Human1.80759557
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80713901
30IRF1_19129219_ChIP-ChIP_H3396_Human1.68151852
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.67874187
32ER_23166858_ChIP-Seq_MCF-7_Human1.66219553
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65358804
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63075830
35CBP_20019798_ChIP-Seq_JUKART_Human1.62061450
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62061450
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60314816
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59319301
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.57494002
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56675704
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53842441
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51705777
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.51444662
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51249811
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50618841
46KLF5_20875108_ChIP-Seq_MESCs_Mouse1.45901576
47ELK1_19687146_ChIP-ChIP_HELA_Human1.44381795
48VDR_23849224_ChIP-Seq_CD4+_Human1.43527770
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.42023845
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.40570461
51STAT3_23295773_ChIP-Seq_U87_Human1.39010490
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37856475
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37856475
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36357540
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33643720
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32441322
57* TCF4_23295773_ChIP-Seq_U87_Human1.31564205
58RNF2_27304074_Chip-Seq_NSC_Mouse1.31311211
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.30409069
60AR_25329375_ChIP-Seq_VCAP_Human1.28434772
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27591482
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.27415428
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27035489
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26941420
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26900039
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23683776
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20662940
68TCF4_22108803_ChIP-Seq_LS180_Human1.17231168
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.16434186
70BCAT_22108803_ChIP-Seq_LS180_Human1.15553592
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15387559
72RUNX2_22187159_ChIP-Seq_PCA_Human1.15046031
73SOX2_19829295_ChIP-Seq_ESCs_Human1.14864207
74NANOG_19829295_ChIP-Seq_ESCs_Human1.14864207
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.14419162
76TP53_22573176_ChIP-Seq_HFKS_Human1.14117053
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13385805
78OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13081300
79MYC_18940864_ChIP-ChIP_HL60_Human1.12550856
80AR_21572438_ChIP-Seq_LNCaP_Human1.12214787
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.10610604
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.09027797
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08719705
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08319404
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06729563
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.06066005
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04045240
88P53_22387025_ChIP-Seq_ESCs_Mouse1.03952428
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03876509
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02562822
91REST_21632747_ChIP-Seq_MESCs_Mouse1.00362986
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00289786
93NCOR_22424771_ChIP-Seq_293T_Human0.99655830
94* ETS1_20019798_ChIP-Seq_JURKAT_Human0.99057215
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97577472
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97240905
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97183577
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95194199
99KDM2B_26808549_Chip-Seq_REH_Human0.94954240
100P300_18555785_Chip-Seq_ESCs_Mouse0.94591020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.23112992
2MP0008877_abnormal_DNA_methylation3.01888353
3MP0002102_abnormal_ear_morphology3.01128271
4MP0006292_abnormal_olfactory_placode2.70431585
5MP0002736_abnormal_nociception_after2.67755574
6MP0001968_abnormal_touch/_nociception2.49714686
7MP0003787_abnormal_imprinting2.33160316
8MP0000569_abnormal_digit_pigmentation2.30592875
9MP0001986_abnormal_taste_sensitivity2.20438172
10MP0003121_genomic_imprinting2.17075454
11MP0000516_abnormal_urinary_system2.15456551
12MP0005367_renal/urinary_system_phenotyp2.15456551
13MP0002735_abnormal_chemical_nociception2.15006405
14MP0003122_maternal_imprinting2.05776155
15MP0006276_abnormal_autonomic_nervous2.04302311
16MP0002751_abnormal_autonomic_nervous1.91920585
17MP0008872_abnormal_physiological_respon1.90490033
18MP0005551_abnormal_eye_electrophysiolog1.82806611
19MP0001529_abnormal_vocalization1.77675885
20MP0006072_abnormal_retinal_apoptosis1.71756892
21MP0002234_abnormal_pharynx_morphology1.70806961
22MP0009745_abnormal_behavioral_response1.70683884
23MP0008058_abnormal_DNA_repair1.69955735
24MP0003567_abnormal_fetal_cardiomyocyte1.63981927
25MP0005075_abnormal_melanosome_morpholog1.59014638
26MP0004142_abnormal_muscle_tone1.58786908
27MP0000427_abnormal_hair_cycle1.55488512
28MP0001486_abnormal_startle_reflex1.53149854
29MP0005253_abnormal_eye_physiology1.52918070
30MP0000631_abnormal_neuroendocrine_gland1.52912033
31MP0002638_abnormal_pupillary_reflex1.51329561
32MP0009046_muscle_twitch1.50692547
33MP0001984_abnormal_olfaction1.49936591
34MP0000778_abnormal_nervous_system1.48102669
35MP0002272_abnormal_nervous_system1.47844495
36MP0001501_abnormal_sleep_pattern1.43606219
37MP0004885_abnormal_endolymph1.39450925
38MP0005386_behavior/neurological_phenoty1.32071005
39MP0004924_abnormal_behavior1.32071005
40MP0002822_catalepsy1.29734651
41MP0002572_abnormal_emotion/affect_behav1.29681247
42MP0008875_abnormal_xenobiotic_pharmacok1.28205436
43MP0003718_maternal_effect1.27468984
44MP0003635_abnormal_synaptic_transmissio1.27380515
45MP0003890_abnormal_embryonic-extraembry1.24143813
46MP0005645_abnormal_hypothalamus_physiol1.23192745
47MP0002067_abnormal_sensory_capabilities1.21969959
48MP0000647_abnormal_sebaceous_gland1.21944563
49MP0000372_irregular_coat_pigmentation1.19840716
50MP0010094_abnormal_chromosome_stability1.19679823
51MP0000383_abnormal_hair_follicle1.18912633
52MP0004859_abnormal_synaptic_plasticity1.18855615
53MP0004043_abnormal_pH_regulation1.17885895
54MP0002938_white_spotting1.15805072
55MP0001485_abnormal_pinna_reflex1.15385822
56MP0002184_abnormal_innervation1.14827894
57MP0002063_abnormal_learning/memory/cond1.14761486
58MP0003646_muscle_fatigue1.11592523
59MP0003221_abnormal_cardiomyocyte_apopto1.06705928
60MP0005646_abnormal_pituitary_gland1.06414861
61MP0004270_analgesia1.06183723
62MP0002734_abnormal_mechanical_nocicepti1.04717338
63MP0008995_early_reproductive_senescence1.02770917
64MP0002557_abnormal_social/conspecific_i1.02428231
65MP0006035_abnormal_mitochondrial_morpho1.02024648
66MP0002064_seizures1.01289106
67MP0004742_abnormal_vestibular_system1.00888955
68MP0004215_abnormal_myocardial_fiber0.99594982
69MP0001970_abnormal_pain_threshold0.99193292
70MP0004133_heterotaxia0.96192486
71MP0003806_abnormal_nucleotide_metabolis0.94265451
72MP0000955_abnormal_spinal_cord0.93518418
73MP0000613_abnormal_salivary_gland0.93462604
74MP0003786_premature_aging0.92873107
75MP0002733_abnormal_thermal_nociception0.92423576
76MP0002882_abnormal_neuron_morphology0.91156893
77MP0002752_abnormal_somatic_nervous0.90516869
78MP0002928_abnormal_bile_duct0.87025075
79MP0003698_abnormal_male_reproductive0.86538659
80MP0002163_abnormal_gland_morphology0.85143883
81MP0002210_abnormal_sex_determination0.83856088
82MP0001929_abnormal_gametogenesis0.83546437
83MP0005310_abnormal_salivary_gland0.82844161
84MP0001293_anophthalmia0.82023924
85MP0005423_abnormal_somatic_nervous0.81431220
86MP0002229_neurodegeneration0.78935390
87MP0000653_abnormal_sex_gland0.77712617
88MP0001145_abnormal_male_reproductive0.77544764
89MP0002160_abnormal_reproductive_system0.76974802
90MP0002152_abnormal_brain_morphology0.76818366
91MP0001502_abnormal_circadian_rhythm0.76450431
92MP0003195_calcinosis0.76185993
93MP0002653_abnormal_ependyma_morphology0.74364923
94MP0003693_abnormal_embryo_hatching0.73841097
95MP0002095_abnormal_skin_pigmentation0.72928774
96MP0005174_abnormal_tail_pigmentation0.72357046
97MP0004147_increased_porphyrin_level0.72271276
98MP0005389_reproductive_system_phenotype0.71539257
99MP0005391_vision/eye_phenotype0.71076328
100MP0004085_abnormal_heartbeat0.71068590

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.46421152
2Hyperventilation (HP:0002883)4.42460862
3Pancreatic cysts (HP:0001737)3.82145267
4Abnormality of midbrain morphology (HP:0002418)3.61601799
5Molar tooth sign on MRI (HP:0002419)3.61601799
6True hermaphroditism (HP:0010459)3.41188914
7Pancreatic fibrosis (HP:0100732)3.39643296
8Methylmalonic acidemia (HP:0002912)3.30344886
9Intestinal atresia (HP:0011100)3.13460032
10Lissencephaly (HP:0001339)3.07760384
11Abnormality of the renal cortex (HP:0011035)2.96706309
12Nephrogenic diabetes insipidus (HP:0009806)2.91044745
13Renal cortical cysts (HP:0000803)2.90693244
14Medial flaring of the eyebrow (HP:0010747)2.87273408
15Congenital stationary night blindness (HP:0007642)2.86012184
16Nephronophthisis (HP:0000090)2.82744983
17Absent speech (HP:0001344)2.68520454
18Abnormal biliary tract physiology (HP:0012439)2.64604455
19Bile duct proliferation (HP:0001408)2.64604455
20Failure to thrive in infancy (HP:0001531)2.61631593
21Gait imbalance (HP:0002141)2.54611952
22Congenital primary aphakia (HP:0007707)2.48564636
23Abnormality of the renal medulla (HP:0100957)2.47255298
24Septo-optic dysplasia (HP:0100842)2.46117669
25Focal motor seizures (HP:0011153)2.39784688
26Hip dysplasia (HP:0001385)2.39305583
27Retrobulbar optic neuritis (HP:0100654)2.36452699
28Optic neuritis (HP:0100653)2.36452699
29Chronic hepatic failure (HP:0100626)2.35953486
30Febrile seizures (HP:0002373)2.35873748
31Methylmalonic aciduria (HP:0012120)2.32943676
32Progressive inability to walk (HP:0002505)2.31539890
33Protruding tongue (HP:0010808)2.25955203
34Optic nerve hypoplasia (HP:0000609)2.22399639
35Narrow forehead (HP:0000341)2.22163768
36Epileptic encephalopathy (HP:0200134)2.18875168
37Broad-based gait (HP:0002136)2.18840466
38Cystic liver disease (HP:0006706)2.18483317
39Fair hair (HP:0002286)2.18156442
40Gaze-evoked nystagmus (HP:0000640)2.10820424
41Patellar aplasia (HP:0006443)2.09591943
42Hyperglycinemia (HP:0002154)2.07840131
43Pachygyria (HP:0001302)2.03588620
44Thyroiditis (HP:0100646)2.03175807
45Volvulus (HP:0002580)2.00990232
46Sloping forehead (HP:0000340)1.98879981
47Colon cancer (HP:0003003)1.98479012
48Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97626876
49Inability to walk (HP:0002540)1.96408296
50Aplasia/Hypoplasia of the tongue (HP:0010295)1.94097345
51Aplasia/Hypoplasia of the patella (HP:0006498)1.93664504
52Ependymoma (HP:0002888)1.93661843
53Keratoconjunctivitis (HP:0001096)1.92465345
54Attenuation of retinal blood vessels (HP:0007843)1.92101711
55Drooling (HP:0002307)1.89582471
56Abnormality of the vitamin B12 metabolism (HP:0004341)1.89143907
57Type II lissencephaly (HP:0007260)1.87559763
58Sclerocornea (HP:0000647)1.87075100
59Postaxial foot polydactyly (HP:0001830)1.86757350
60Genital tract atresia (HP:0001827)1.84957709
61Supernumerary spleens (HP:0009799)1.83608697
62Vaginal atresia (HP:0000148)1.83598727
63Stomach cancer (HP:0012126)1.83210071
64Abolished electroretinogram (ERG) (HP:0000550)1.82684150
65Growth hormone deficiency (HP:0000824)1.82476453
66Panhypogammaglobulinemia (HP:0003139)1.82243125
67Oculomotor apraxia (HP:0000657)1.81625058
68Postaxial hand polydactyly (HP:0001162)1.80333120
69Hepatocellular necrosis (HP:0001404)1.79004001
70Abnormal hair whorl (HP:0010721)1.78747200
71Abnormality of vitamin B metabolism (HP:0004340)1.77901012
72Progressive macrocephaly (HP:0004481)1.77210398
73Hypoproteinemia (HP:0003075)1.77199283
74Small hand (HP:0200055)1.76938120
75Keratoconjunctivitis sicca (HP:0001097)1.76885788
76Abnormality of lateral ventricle (HP:0030047)1.76748884
77Cerebellar dysplasia (HP:0007033)1.75877120
78Excessive salivation (HP:0003781)1.75724452
79Neoplasm of the oral cavity (HP:0100649)1.75398860
80Anencephaly (HP:0002323)1.73768314
81Abnormality of the ileum (HP:0001549)1.69362403
82Tented upper lip vermilion (HP:0010804)1.69335875
83Polydipsia (HP:0001959)1.69211899
84Abnormal drinking behavior (HP:0030082)1.69211899
85Male pseudohermaphroditism (HP:0000037)1.68389245
86Orchitis (HP:0100796)1.67159343
87Poor coordination (HP:0002370)1.65393704
88Agitation (HP:0000713)1.65140599
89Increased CSF lactate (HP:0002490)1.64106030
90Polyuria (HP:0000103)1.62486011
91Encephalitis (HP:0002383)1.62401368
92Abnormal rod and cone electroretinograms (HP:0008323)1.61593274
93Oligodactyly (hands) (HP:0001180)1.59920607
94Retinal dysplasia (HP:0007973)1.59629297
95Dandy-Walker malformation (HP:0001305)1.59100404
96Pendular nystagmus (HP:0012043)1.58498613
97Hepatic necrosis (HP:0002605)1.58262462
98Abnormal delayed hypersensitivity skin test (HP:0002963)1.58220892
99Meckel diverticulum (HP:0002245)1.57852290
100Generalized hypopigmentation of hair (HP:0011358)1.56539310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.13043460
2CASK3.91103513
3WNK33.46285669
4MAP4K23.34924376
5MARK12.92778169
6MAPK132.80737642
7TRIM282.56431663
8NUAK12.41560922
9TAOK32.13001672
10ZAK1.87216530
11EPHA41.79510855
12MKNK21.75858383
13BMPR1B1.74341637
14BCR1.70065229
15PINK11.66399352
16MAP3K41.66158079
17ERBB41.57993706
18SRPK11.52858274
19ADRBK21.47996669
20DYRK1A1.40688910
21TNIK1.38643735
22ACVR1B1.32409267
23EIF2AK31.28695463
24GRK11.25545471
25TXK1.25300083
26CSNK1G21.19681169
27MKNK11.17332077
28BRD41.14997647
29STK38L1.14588154
30DYRK21.14221093
31MAP2K71.13199302
32PLK31.11135973
33ERBB31.09170410
34CSNK1G11.07747981
35TAF11.06059141
36PASK1.01497729
37EPHA30.98898821
38OXSR10.97614233
39VRK10.93981017
40PIK3CA0.93588547
41YES10.92418404
42PLK20.92292558
43CAMKK20.91411889
44CSNK1G30.87222420
45VRK20.86169109
46UHMK10.85354990
47PNCK0.84013920
48PBK0.83519654
49BRSK20.82752760
50PRKCG0.80216285
51PAK30.78029242
52CCNB10.77654783
53CSNK1A1L0.77599005
54TSSK60.77315762
55DYRK1B0.77215368
56FGFR30.75474306
57CDK30.70016843
58INSRR0.69275656
59BUB10.69272735
60PLK40.64379048
61NLK0.60219893
62FGFR20.57716202
63PRKCE0.56395727
64TNK20.55979782
65ATM0.55322280
66MST40.54785394
67PLK10.53776738
68CLK10.53376780
69ATR0.52240864
70PKN10.51353678
71RPS6KA40.51334558
72TGFBR10.50848142
73STK390.50215013
74DAPK10.49778039
75SIK30.47210872
76WNK40.47004557
77DAPK20.45655602
78CAMK2A0.44611936
79PRKCQ0.44610083
80NEK90.43693548
81CAMK40.43686005
82ADRBK10.42687896
83IRAK10.42316665
84CSNK1D0.42125857
85MINK10.42034998
86SGK20.41870239
87CSNK1A10.40438189
88CSNK1E0.35524949
89BCKDK0.35227072
90CAMK2B0.34528719
91GRK70.32932386
92NTRK30.31225475
93PRKACA0.30744766
94PRKACB0.30642849
95PRKCB0.29297614
96EIF2AK10.28697323
97EIF2AK20.28225670
98PRKG10.27601006
99PRKCA0.27510302
100MAPK40.27454573

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.19666102
2Non-homologous end-joining_Homo sapiens_hsa034503.03647085
3Propanoate metabolism_Homo sapiens_hsa006402.83737012
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.79677353
5Fanconi anemia pathway_Homo sapiens_hsa034602.67126123
6Butanoate metabolism_Homo sapiens_hsa006502.37647582
7Phototransduction_Homo sapiens_hsa047442.30308379
8Homologous recombination_Homo sapiens_hsa034402.29503714
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.24113536
10Nicotine addiction_Homo sapiens_hsa050332.20318617
11RNA polymerase_Homo sapiens_hsa030202.19354436
12Basal transcription factors_Homo sapiens_hsa030222.15983191
13Primary immunodeficiency_Homo sapiens_hsa053402.12384710
14Protein export_Homo sapiens_hsa030602.05474079
15RNA degradation_Homo sapiens_hsa030181.83897927
16Circadian rhythm_Homo sapiens_hsa047101.80763532
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72061489
18Tryptophan metabolism_Homo sapiens_hsa003801.67714504
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67068399
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65553037
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64842931
22Ether lipid metabolism_Homo sapiens_hsa005651.61577312
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60991189
24Taste transduction_Homo sapiens_hsa047421.52945204
25Linoleic acid metabolism_Homo sapiens_hsa005911.47920130
26Caffeine metabolism_Homo sapiens_hsa002321.44796441
27Nitrogen metabolism_Homo sapiens_hsa009101.38398310
28Olfactory transduction_Homo sapiens_hsa047401.32797469
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28883195
30Steroid biosynthesis_Homo sapiens_hsa001001.28127280
31Selenocompound metabolism_Homo sapiens_hsa004501.24652258
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22355013
33Spliceosome_Homo sapiens_hsa030401.16989105
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.15887722
35Oxidative phosphorylation_Homo sapiens_hsa001901.15458497
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10109221
37Mismatch repair_Homo sapiens_hsa034301.09451421
38Fatty acid elongation_Homo sapiens_hsa000621.09240812
39RNA transport_Homo sapiens_hsa030131.06575484
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05718036
41Lysine degradation_Homo sapiens_hsa003101.04834760
42Morphine addiction_Homo sapiens_hsa050321.01501850
43Regulation of autophagy_Homo sapiens_hsa041400.96804238
44Peroxisome_Homo sapiens_hsa041460.95652110
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85773767
46Glutamatergic synapse_Homo sapiens_hsa047240.85712093
47Parkinsons disease_Homo sapiens_hsa050120.85672572
48Purine metabolism_Homo sapiens_hsa002300.85454174
49Nucleotide excision repair_Homo sapiens_hsa034200.84033154
50Collecting duct acid secretion_Homo sapiens_hsa049660.80050882
51Circadian entrainment_Homo sapiens_hsa047130.78174069
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.77987713
53One carbon pool by folate_Homo sapiens_hsa006700.77656714
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77091531
55GABAergic synapse_Homo sapiens_hsa047270.75281749
56ABC transporters_Homo sapiens_hsa020100.75277755
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75110849
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74785792
59Chemical carcinogenesis_Homo sapiens_hsa052040.71428353
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.71004673
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.70624290
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69664831
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69285643
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68992233
65Proteasome_Homo sapiens_hsa030500.68779951
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.68228290
67Base excision repair_Homo sapiens_hsa034100.66104659
68Pyrimidine metabolism_Homo sapiens_hsa002400.64472552
69Dopaminergic synapse_Homo sapiens_hsa047280.62348096
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61462432
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60077915
72beta-Alanine metabolism_Homo sapiens_hsa004100.58924427
73Dorso-ventral axis formation_Homo sapiens_hsa043200.57005440
74Pyruvate metabolism_Homo sapiens_hsa006200.56064606
75Huntingtons disease_Homo sapiens_hsa050160.55850721
76Retinol metabolism_Homo sapiens_hsa008300.52137840
77Glycerolipid metabolism_Homo sapiens_hsa005610.51777867
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51069293
79Serotonergic synapse_Homo sapiens_hsa047260.49732323
80Metabolic pathways_Homo sapiens_hsa011000.49368750
81Fatty acid metabolism_Homo sapiens_hsa012120.49178857
82Amphetamine addiction_Homo sapiens_hsa050310.48977963
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.47974161
84Long-term depression_Homo sapiens_hsa047300.46537969
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46115176
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44952672
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44292305
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43423204
89Salivary secretion_Homo sapiens_hsa049700.42578945
90Hedgehog signaling pathway_Homo sapiens_hsa043400.42107359
91Antigen processing and presentation_Homo sapiens_hsa046120.40492562
92Fat digestion and absorption_Homo sapiens_hsa049750.39974392
93DNA replication_Homo sapiens_hsa030300.39413650
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39412119
95Oocyte meiosis_Homo sapiens_hsa041140.38441915
96Axon guidance_Homo sapiens_hsa043600.38008980
97Fatty acid degradation_Homo sapiens_hsa000710.37295421
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35899774
99mRNA surveillance pathway_Homo sapiens_hsa030150.35820915
100Cocaine addiction_Homo sapiens_hsa050300.33209397

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