ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	5.16343874
2	piRNA metabolic process (GO:0034587)	3.92833247
3	neural tube formation (GO:0001841)	3.87775675
4	DNA methylation involved in gamete generation (GO:0043046)	3.75447303
5	cilium morphogenesis (GO:0060271)	3.60323270
6	respiratory chain complex IV assembly (GO:0008535)	3.59852954
7	protein localization to cilium (GO:0061512)	3.58299767
8	indolalkylamine metabolic process (GO:0006586)	3.50699460
9	cell wall macromolecule catabolic process (GO:0016998)	3.43480560
10	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.41587781
11	cullin deneddylation (GO:0010388)	3.40872857
12	regulation of meiosis I (GO:0060631)	3.35133242
13	platelet dense granule organization (GO:0060155)	3.35075432
14	protein K11-linked deubiquitination (GO:0035871)	3.34796710
15	protein K11-linked ubiquitination (GO:0070979)	3.22502260
16	DNA integration (GO:0015074)	3.21643421
17	tryptophan catabolic process (GO:0006569)	3.21022932
18	indole-containing compound catabolic process (GO:0042436)	3.21022932
19	indolalkylamine catabolic process (GO:0046218)	3.21022932
20	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.18906223
21	recombinational repair (GO:0000725)	3.17968328
22	positive regulation of prostaglandin secretion (GO:0032308)	3.17441310
23	double-strand break repair via homologous recombination (GO:0000724)	3.12340844
24	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.09540401
25	protein deneddylation (GO:0000338)	3.08270066
26	nonmotile primary cilium assembly (GO:0035058)	3.08150034
27	photoreceptor cell maintenance (GO:0045494)	3.02037622
28	cytochrome complex assembly (GO:0017004)	3.00833221
29	GPI anchor metabolic process (GO:0006505)	2.98227268
30	preassembly of GPI anchor in ER membrane (GO:0016254)	2.97393730
31	proteasome assembly (GO:0043248)	2.93410432
32	tryptophan metabolic process (GO:0006568)	2.92733312
33	microtubule anchoring (GO:0034453)	2.90830091
34	water-soluble vitamin biosynthetic process (GO:0042364)	2.90221196
35	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.89749885
36	regulation of translation, ncRNA-mediated (GO:0045974)	2.89749885
37	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.89749885
38	resolution of meiotic recombination intermediates (GO:0000712)	2.88223687
39	mannosylation (GO:0097502)	2.88137669
40	male meiosis I (GO:0007141)	2.87839943
41	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.87415704
42	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.87415704
43	organelle disassembly (GO:1903008)	2.86491137
44	histone H2A acetylation (GO:0043968)	2.84763325
45	amino acid salvage (GO:0043102)	2.82704259
46	L-methionine salvage (GO:0071267)	2.82704259
47	L-methionine biosynthetic process (GO:0071265)	2.82704259
48	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.81853402
49	DNA catabolic process, exonucleolytic (GO:0000738)	2.81812955
50	reflex (GO:0060004)	2.81056240
51	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.78716128
52	cell wall macromolecule metabolic process (GO:0044036)	2.78553201
53	regulation of glucokinase activity (GO:0033131)	2.78546881
54	regulation of hexokinase activity (GO:1903299)	2.78546881
55	DNA demethylation (GO:0080111)	2.78371749
56	peptidyl-histidine modification (GO:0018202)	2.77152277
57	mitochondrial fission (GO:0000266)	2.77078836
58	regulation of cilium movement (GO:0003352)	2.76633052
59	centriole replication (GO:0007099)	2.76532768
60	cilium organization (GO:0044782)	2.76199489
61	positive regulation of mitochondrial fission (GO:0090141)	2.75514703
62	melanosome transport (GO:0032402)	2.73139937
63	sphingosine metabolic process (GO:0006670)	2.72468445
64	retinal cone cell development (GO:0046549)	2.72379574
65	replication fork processing (GO:0031297)	2.71076781
66	cilium assembly (GO:0042384)	2.70146928
67	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.68554720
68	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.68303034
69	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.68303034
70	regulation of prostaglandin secretion (GO:0032306)	2.67698541
71	Golgi to endosome transport (GO:0006895)	2.67569192
72	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.66084618
73	fibroblast migration (GO:0010761)	2.63608029
74	intraciliary transport (GO:0042073)	2.63311650
75	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.60931507
76	C-terminal protein lipidation (GO:0006501)	2.60799356
77	retinal rod cell development (GO:0046548)	2.59687773
78	C-terminal protein amino acid modification (GO:0018410)	2.57215320
79	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.56057801
80	brain morphogenesis (GO:0048854)	2.55310637
81	melanosome localization (GO:0032400)	2.55286333
82	regulation of telomere maintenance (GO:0032204)	2.54665280
83	ubiquinone metabolic process (GO:0006743)	2.54323734
84	kidney morphogenesis (GO:0060993)	2.53754935
85	regulation of helicase activity (GO:0051095)	2.53721583
86	pigment granule transport (GO:0051904)	2.53560811
87	response to pheromone (GO:0019236)	2.53330084
88	protein-chromophore linkage (GO:0018298)	2.52931755
89	prostate gland growth (GO:0060736)	2.52800765
90	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.52433043
91	regulation of mitotic spindle checkpoint (GO:1903504)	2.52433043
92	establishment of melanosome localization (GO:0032401)	2.52229661
93	non-recombinational repair (GO:0000726)	2.51888603
94	double-strand break repair via nonhomologous end joining (GO:0006303)	2.51888603
95	postreplication repair (GO:0006301)	2.51817582
96	male meiosis (GO:0007140)	2.49571185
97	sphingoid metabolic process (GO:0046519)	2.49568830
98	pseudouridine synthesis (GO:0001522)	2.49323906
99	lactate metabolic process (GO:0006089)	2.48179386
100	protein-cofactor linkage (GO:0018065)	2.47573193

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.75314979
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.83601185
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.81738855
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.76675523
5	VDR_22108803_ChIP-Seq_LS180_Human	2.72572597
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.50389858
7	FUS_26573619_Chip-Seq_HEK293_Human	2.47829245
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.44058086
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.43515884
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.41271022
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.37200776
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.36188303
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.32488014
14	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27827463
15	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.26319974
16	IRF1_19129219_ChIP-ChIP_H3396_Human	2.16626115
17	P300_19829295_ChIP-Seq_ESCs_Human	2.12209369
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.11836626
19	EWS_26573619_Chip-Seq_HEK293_Human	2.08906360
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.07193797
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05631328
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.99609358
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.97294532
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.94242906
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.91010878
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.87377563
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76018806
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.73600777
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.67119915
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.66631771
31	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.64302934
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.62843719
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.62796116
34	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.62377677
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59398569
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.52167753
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52167753
38	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.51324959
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.50853830
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49764151
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.48699368
42	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.47062667
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46038152
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44309497
45	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.43739869
46	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.43076050
47	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41562678
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.41519798
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36526821
50	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.36418840
51	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.35326646
52	STAT3_23295773_ChIP-Seq_U87_Human	1.35006631
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33200823
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33200823
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.31710718
56	FOXP3_21729870_ChIP-Seq_TREG_Human	1.31379235
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30930953
58	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.30586742
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30288293
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30258226
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.27022958
62	AR_25329375_ChIP-Seq_VCAP_Human	1.25728353
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25655081
64	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.25220415
65	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.24112906
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22617578
67	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.22102076
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.21657251
69	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21562455
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21276012
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.21131425
72	CDX2_22108803_ChIP-Seq_LS180_Human	1.20007334
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19651779
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19569800
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19343479
76	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.19294974
77	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19294974
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.17019365
79	TCF4_23295773_ChIP-Seq_U87_Human	1.15883431
80	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.15142345
81	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.13762382
82	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.12016811
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11540679
84	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.11026013
85	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.09698281
86	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.09117330
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09082371
88	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.08389663
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07734447
90	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06502085
91	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.05906103
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.04949699
93	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.04332562
94	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03964625
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03964625
96	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.03954435
97	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03098001
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02955335
99	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.02432551
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01595863

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	4.45965903
2	MP0002837_dystrophic_cardiac_calcinosis	3.98718068
3	MP0008877_abnormal_DNA_methylation	3.65501482
4	MP0002653_abnormal_ependyma_morphology	3.06936726
5	MP0001984_abnormal_olfaction	2.89475542
6	MP0006054_spinal_hemorrhage	2.76746495
7	MP0008789_abnormal_olfactory_epithelium	2.67465169
8	MP0008058_abnormal_DNA_repair	2.61337197
9	MP0003195_calcinosis	2.60938731
10	MP0000516_abnormal_urinary_system	2.47512213
11	MP0005367_renal/urinary_system_phenotyp	2.47512213
12	MP0002102_abnormal_ear_morphology	2.32391254
13	MP0002234_abnormal_pharynx_morphology	2.18458293
14	MP0005394_taste/olfaction_phenotype	2.11383606
15	MP0005499_abnormal_olfactory_system	2.11383606
16	MP0003880_abnormal_central_pattern	2.09052147
17	MP0006276_abnormal_autonomic_nervous	2.02789886
18	MP0003787_abnormal_imprinting	1.86803264
19	MP0010094_abnormal_chromosome_stability	1.82162375
20	MP0000427_abnormal_hair_cycle	1.76197405
21	MP0003890_abnormal_embryonic-extraembry	1.76029502
22	MP0005253_abnormal_eye_physiology	1.74300637
23	MP0000569_abnormal_digit_pigmentation	1.68308706
24	MP0009697_abnormal_copulation	1.67624644
25	MP0006072_abnormal_retinal_apoptosis	1.64514126
26	MP0003718_maternal_effect	1.64490812
27	MP0002254_reproductive_system_inflammat	1.63954248
28	MP0002751_abnormal_autonomic_nervous	1.61605645
29	MP0005551_abnormal_eye_electrophysiolog	1.59718035
30	MP0002138_abnormal_hepatobiliary_system	1.59620424
31	MP0006035_abnormal_mitochondrial_morpho	1.46369852
32	MP0002139_abnormal_hepatobiliary_system	1.44650891
33	MP0004215_abnormal_myocardial_fiber	1.43335239
34	MP0005075_abnormal_melanosome_morpholog	1.42929607
35	MP0002638_abnormal_pupillary_reflex	1.41422252
36	MP0004043_abnormal_pH_regulation	1.39856212
37	MP0003121_genomic_imprinting	1.36953005
38	MP0005248_abnormal_Harderian_gland	1.32851198
39	MP0001529_abnormal_vocalization	1.32242435
40	MP0009046_muscle_twitch	1.23693853
41	MP0000383_abnormal_hair_follicle	1.21568285
42	MP0008995_early_reproductive_senescence	1.20560591
43	MP0003122_maternal_imprinting	1.19260113
44	MP0005646_abnormal_pituitary_gland	1.19158413
45	MP0003011_delayed_dark_adaptation	1.18459371
46	MP0005171_absent_coat_pigmentation	1.15632906
47	MP0003646_muscle_fatigue	1.14502182
48	MP0001764_abnormal_homeostasis	1.13893490
49	MP0000631_abnormal_neuroendocrine_gland	1.10070442
50	MP0001929_abnormal_gametogenesis	1.09904370
51	MP0001177_atelectasis	1.09237724
52	MP0004147_increased_porphyrin_level	1.08360000
53	MP0003567_abnormal_fetal_cardiomyocyte	1.08238207
54	MP0008007_abnormal_cellular_replicative	1.07141441
55	MP0000647_abnormal_sebaceous_gland	1.06987103
56	MP0005647_abnormal_sex_gland	1.06451497
57	MP0002233_abnormal_nose_morphology	1.04705528
58	MP0005266_abnormal_metabolism	1.03005896
59	MP0003698_abnormal_male_reproductive	1.02379069
60	MP0000372_irregular_coat_pigmentation	1.00692549
61	MP0010678_abnormal_skin_adnexa	1.00390073
62	MP0000778_abnormal_nervous_system	0.99684184
63	MP0002938_white_spotting	0.96732732
64	MP0008775_abnormal_heart_ventricle	0.96539175
65	MP0003136_yellow_coat_color	0.93283914
66	MP0002736_abnormal_nociception_after	0.92844890
67	MP0002160_abnormal_reproductive_system	0.89406053
68	MP0001968_abnormal_touch/_nociception	0.88743519
69	MP0005395_other_phenotype	0.87872916
70	MP0003221_abnormal_cardiomyocyte_apopto	0.87231551
71	MP0001501_abnormal_sleep_pattern	0.86606144
72	MP0001293_anophthalmia	0.85937053
73	MP0008872_abnormal_physiological_respon	0.84306043
74	MP0002277_abnormal_respiratory_mucosa	0.83922107
75	MP0002210_abnormal_sex_determination	0.83800068
76	MP0002090_abnormal_vision	0.82197489
77	MP0000653_abnormal_sex_gland	0.81427002
78	MP0005389_reproductive_system_phenotype	0.80819367
79	MP0001324_abnormal_eye_pigmentation	0.80458755
80	MP0008875_abnormal_xenobiotic_pharmacok	0.79361695
81	MP0000230_abnormal_systemic_arterial	0.78285526
82	MP0002876_abnormal_thyroid_physiology	0.78245740
83	MP0001145_abnormal_male_reproductive	0.77707031
84	MP0003693_abnormal_embryo_hatching	0.77645302
85	MP0005410_abnormal_fertilization	0.77535546
86	MP0001986_abnormal_taste_sensitivity	0.76364477
87	MP0003786_premature_aging	0.74410415
88	MP0001486_abnormal_startle_reflex	0.73395463
89	MP0003137_abnormal_impulse_conducting	0.72388232
90	MP0004484_altered_response_of	0.69954701
91	MP0002909_abnormal_adrenal_gland	0.68845308
92	MP0005084_abnormal_gallbladder_morpholo	0.67667648
93	MP0008961_abnormal_basal_metabolism	0.67475255
94	MP0004142_abnormal_muscle_tone	0.67255089
95	MP0001119_abnormal_female_reproductive	0.67087935
96	MP0003937_abnormal_limbs/digits/tail_de	0.65471292
97	MP0004133_heterotaxia	0.65220310
98	MP0005386_behavior/neurological_phenoty	0.65192682
99	MP0004924_abnormal_behavior	0.65192682
100	MP0005195_abnormal_posterior_eye	0.64176684

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.64520704
2	True hermaphroditism (HP:0010459)	3.82175627
3	Pancreatic fibrosis (HP:0100732)	3.81403978
4	Nephronophthisis (HP:0000090)	3.65583941
5	Abnormality of midbrain morphology (HP:0002418)	3.52651984
6	Molar tooth sign on MRI (HP:0002419)	3.52651984
7	3-Methylglutaconic aciduria (HP:0003535)	3.33872599
8	Chronic hepatic failure (HP:0100626)	3.22427107
9	Tubular atrophy (HP:0000092)	3.20929573
10	Abnormality of the labia minora (HP:0012880)	3.13785504
11	Colon cancer (HP:0003003)	3.13028309
12	Abnormality of the renal medulla (HP:0100957)	3.03572636
13	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.98825728
14	Medial flaring of the eyebrow (HP:0010747)	2.97581694
15	Thyroid-stimulating hormone excess (HP:0002925)	2.71001549
16	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.65952286
17	Abnormal protein N-linked glycosylation (HP:0012347)	2.65952286
18	Abnormal protein glycosylation (HP:0012346)	2.65952286
19	Abnormal glycosylation (HP:0012345)	2.65952286
20	Hematochezia (HP:0002573)	2.64153676
21	Abnormality of the renal cortex (HP:0011035)	2.62403520
22	Abnormal biliary tract physiology (HP:0012439)	2.56101263
23	Bile duct proliferation (HP:0001408)	2.56101263
24	Congenital primary aphakia (HP:0007707)	2.55778232
25	Meckel diverticulum (HP:0002245)	2.48125280
26	Nephrogenic diabetes insipidus (HP:0009806)	2.45400293
27	Gait imbalance (HP:0002141)	2.45374567
28	Type II lissencephaly (HP:0007260)	2.44853851
29	Occipital encephalocele (HP:0002085)	2.40065829
30	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.39554323
31	Abnormality of the ileum (HP:0001549)	2.38770806
32	Type I transferrin isoform profile (HP:0003642)	2.37874945
33	Genital tract atresia (HP:0001827)	2.35306826
34	Cystic liver disease (HP:0006706)	2.31401724
35	Abnormality of chromosome stability (HP:0003220)	2.29021341
36	Ependymoma (HP:0002888)	2.28746425
37	Progressive macrocephaly (HP:0004481)	2.28681043
38	Sclerocornea (HP:0000647)	2.25565565
39	Vaginal atresia (HP:0000148)	2.25054975
40	Intestinal atresia (HP:0011100)	2.23864763
41	Cerebellar dysplasia (HP:0007033)	2.22530260
42	Furrowed tongue (HP:0000221)	2.20435185
43	Aplasia/hypoplasia of the uterus (HP:0008684)	2.19916275
44	Clubbing of toes (HP:0100760)	2.15173522
45	Acute necrotizing encephalopathy (HP:0006965)	2.14708977
46	Hypothermia (HP:0002045)	2.13784690
47	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.10878834
48	Anencephaly (HP:0002323)	2.09753599
49	Abnormality of the preputium (HP:0100587)	2.08886807
50	Focal motor seizures (HP:0011153)	2.08115738
51	Increased CSF lactate (HP:0002490)	2.07385758
52	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.04063135
53	Progressive inability to walk (HP:0002505)	2.02795518
54	Dyschromatopsia (HP:0007641)	1.98373167
55	Acute encephalopathy (HP:0006846)	1.98180271
56	Congenital hepatic fibrosis (HP:0002612)	1.96841936
57	Tubulointerstitial nephritis (HP:0001970)	1.96334081
58	Central scotoma (HP:0000603)	1.94286873
59	Neoplasm of the adrenal cortex (HP:0100641)	1.94200316
60	Agnosia (HP:0010524)	1.93653111
61	Hyperventilation (HP:0002883)	1.92216045
62	Inability to walk (HP:0002540)	1.92116766
63	Neonatal respiratory distress (HP:0002643)	1.92064870
64	Chorioretinal coloboma (HP:0000567)	1.88225606
65	Increased serum lactate (HP:0002151)	1.87739687
66	Microvesicular hepatic steatosis (HP:0001414)	1.87178488
67	Mitochondrial inheritance (HP:0001427)	1.86954876
68	Chromsome breakage (HP:0040012)	1.86595296
69	Stenosis of the external auditory canal (HP:0000402)	1.85993438
70	Duodenal stenosis (HP:0100867)	1.83974266
71	Small intestinal stenosis (HP:0012848)	1.83974266
72	Gaze-evoked nystagmus (HP:0000640)	1.83011108
73	Dialeptic seizures (HP:0011146)	1.81958343
74	Sloping forehead (HP:0000340)	1.81954027
75	Congenital stationary night blindness (HP:0007642)	1.81671127
76	Postaxial hand polydactyly (HP:0001162)	1.81186134
77	Poor coordination (HP:0002370)	1.80878760
78	Lissencephaly (HP:0001339)	1.80655878
79	Abnormality of the duodenum (HP:0002246)	1.80052547
80	Hypoplasia of the uterus (HP:0000013)	1.79766720
81	Dandy-Walker malformation (HP:0001305)	1.79500065
82	Hepatocellular necrosis (HP:0001404)	1.79116526
83	Abnormal drinking behavior (HP:0030082)	1.78565060
84	Polydipsia (HP:0001959)	1.78565060
85	Thyroiditis (HP:0100646)	1.78153346
86	Attenuation of retinal blood vessels (HP:0007843)	1.77764931
87	Short tibia (HP:0005736)	1.77637100
88	Preaxial hand polydactyly (HP:0001177)	1.76187959
89	Glioma (HP:0009733)	1.76008933
90	Bifid tongue (HP:0010297)	1.75868732
91	Abolished electroretinogram (ERG) (HP:0000550)	1.73681805
92	Retinal dysplasia (HP:0007973)	1.73567519
93	Astrocytoma (HP:0009592)	1.72622946
94	Abnormality of the astrocytes (HP:0100707)	1.72622946
95	Breast carcinoma (HP:0003002)	1.72567931
96	Male pseudohermaphroditism (HP:0000037)	1.72014261
97	Postaxial foot polydactyly (HP:0001830)	1.70590318
98	Prominent nasal bridge (HP:0000426)	1.70200864
99	Methylmalonic acidemia (HP:0002912)	1.68929608
100	Oligohydramnios (HP:0001562)	1.68664950

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.84875706
2	MST4	3.82584852
3	STK38L	3.08895277
4	WNK3	2.86042573
5	TRIM28	2.71366934
6	MAP4K2	2.67009166
7	BMPR1B	2.66926909
8	NUAK1	2.57429946
9	EIF2AK3	2.30237821
10	BCR	2.18837615
11	MKNK2	2.15684734
12	SRPK1	2.05271801
13	ZAK	2.05208512
14	FGFR2	1.88357376
15	ACVR1B	1.88007566
16	BRSK2	1.87470392
17	LATS1	1.83266234
18	MAP3K4	1.80890950
19	STK3	1.75099385
20	ADRBK2	1.73156508
21	MKNK1	1.67439946
22	ERBB3	1.51588258
23	CASK	1.50229601
24	OXSR1	1.39795678
25	DYRK3	1.37687343
26	PLK2	1.31197617
27	GRK1	1.28779595
28	AKT3	1.27264961
29	TSSK6	1.24135647
30	PLK3	1.22012374
31	STK39	1.16164652
32	NLK	1.15789827
33	EPHA4	1.14684434
34	BCKDK	1.07616053
35	TGFBR1	1.04685933
36	CSNK1G1	1.03857981
37	PAK3	1.03427339
38	TAF1	1.01786236
39	CSNK1A1L	0.99871377
40	CSNK1G3	0.99191280
41	CSNK1G2	0.96142214
42	MAP2K7	0.95934478
43	PINK1	0.94359898
44	PRKCE	0.93269238
45	MAPK13	0.92577208
46	MAP3K5	0.89417850
47	VRK1	0.88708740
48	WEE1	0.88297619
49	PLK1	0.81424258
50	TLK1	0.80642337
51	INSRR	0.80483503
52	EIF2AK2	0.73456730
53	GRK7	0.70857617
54	STK38	0.66099099
55	VRK2	0.62885273
56	BUB1	0.62516398
57	TNIK	0.62416617
58	DYRK2	0.61936760
59	SIK3	0.60226431
60	RPS6KA4	0.59662435
61	DYRK1A	0.58208355
62	TIE1	0.54947613
63	WNK4	0.53339015
64	TTK	0.50909943
65	ATR	0.50753649
66	TEC	0.47813989
67	ATM	0.47798649
68	ADRBK1	0.47182927
69	STK10	0.44440577
70	MARK3	0.44358328
71	STK4	0.42644305
72	BRD4	0.41822937
73	RPS6KA5	0.41035023
74	CCNB1	0.39927257
75	MAP3K12	0.39162136
76	FER	0.38725080
77	TAOK3	0.37242573
78	DYRK1B	0.37110481
79	CHUK	0.34621448
80	PRKCI	0.33769686
81	PLK4	0.33646368
82	NTRK3	0.32311243
83	PNCK	0.32138565
84	CDK19	0.31755695
85	OBSCN	0.31454269
86	TNK2	0.30778008
87	CAMKK2	0.28391273
88	MAP2K4	0.27894103
89	CSNK1D	0.27666061
90	MELK	0.27500224
91	PRKAA1	0.26360440
92	EPHA3	0.26151596
93	PRKAA2	0.26101781
94	CSNK1A1	0.25966511
95	CDK3	0.25527422
96	CAMK2A	0.25312446
97	CDK9	0.24747789
98	PRKCG	0.24082785
99	SGK2	0.24060222
100	IKBKB	0.22663796

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.52488336
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.01292906
3	Protein export_Homo sapiens_hsa03060	2.89537190
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.84346998
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.77694527
6	Propanoate metabolism_Homo sapiens_hsa00640	2.72738328
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.64932650
8	Phototransduction_Homo sapiens_hsa04744	2.53937947
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.50745308
10	Butanoate metabolism_Homo sapiens_hsa00650	2.40848513
11	Basal transcription factors_Homo sapiens_hsa03022	2.31613707
12	Proteasome_Homo sapiens_hsa03050	2.25539902
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.23004650
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.07702044
15	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.92991620
16	Homologous recombination_Homo sapiens_hsa03440	1.73355529
17	Regulation of autophagy_Homo sapiens_hsa04140	1.72727350
18	RNA polymerase_Homo sapiens_hsa03020	1.68829458
19	RNA degradation_Homo sapiens_hsa03018	1.52103688
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.49304180
21	Peroxisome_Homo sapiens_hsa04146	1.49175257
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.44074420
23	One carbon pool by folate_Homo sapiens_hsa00670	1.41062482
24	Fatty acid elongation_Homo sapiens_hsa00062	1.40779221
25	Oxidative phosphorylation_Homo sapiens_hsa00190	1.36007033
26	Taste transduction_Homo sapiens_hsa04742	1.34871809
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.33720052
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29499143
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.26423020
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.24709730
31	Collecting duct acid secretion_Homo sapiens_hsa04966	1.23890175
32	Caffeine metabolism_Homo sapiens_hsa00232	1.21937836
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.21664410
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21580484
35	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.20368919
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.15940047
37	p53 signaling pathway_Homo sapiens_hsa04115	1.14002526
38	RNA transport_Homo sapiens_hsa03013	1.10006409
39	Nicotine addiction_Homo sapiens_hsa05033	1.07283529
40	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.03927247
41	Mismatch repair_Homo sapiens_hsa03430	1.02667168
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.02510614
43	Retinol metabolism_Homo sapiens_hsa00830	0.99830430
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.97812367
45	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96383106
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94676924
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.92528273
48	Base excision repair_Homo sapiens_hsa03410	0.92504561
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.92094350
50	Sphingolipid metabolism_Homo sapiens_hsa00600	0.91574455
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.91219870
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.89506563
53	Parkinsons disease_Homo sapiens_hsa05012	0.88194924
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.83352462
55	Circadian rhythm_Homo sapiens_hsa04710	0.82842780
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.82412871
57	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80865444
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.76983346
59	GABAergic synapse_Homo sapiens_hsa04727	0.76971031
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76232875
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75197254
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73852733
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73553427
64	Purine metabolism_Homo sapiens_hsa00230	0.70538829
65	mRNA surveillance pathway_Homo sapiens_hsa03015	0.68909324
66	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.66104489
67	Asthma_Homo sapiens_hsa05310	0.65111800
68	Oocyte meiosis_Homo sapiens_hsa04114	0.63427143
69	Morphine addiction_Homo sapiens_hsa05032	0.62498489
70	Cell cycle_Homo sapiens_hsa04110	0.62201708
71	Type I diabetes mellitus_Homo sapiens_hsa04940	0.61153182
72	Olfactory transduction_Homo sapiens_hsa04740	0.61064717
73	Sulfur metabolism_Homo sapiens_hsa00920	0.60430018
74	Spliceosome_Homo sapiens_hsa03040	0.59877891
75	Fatty acid metabolism_Homo sapiens_hsa01212	0.59183894
76	Huntingtons disease_Homo sapiens_hsa05016	0.58917126
77	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.58045351
78	Metabolic pathways_Homo sapiens_hsa01100	0.57600252
79	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.54077891
80	Nucleotide excision repair_Homo sapiens_hsa03420	0.53076646
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52295121
82	Serotonergic synapse_Homo sapiens_hsa04726	0.48949852
83	Glutathione metabolism_Homo sapiens_hsa00480	0.46223256
84	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.45523988
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44781120
86	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.44645933
87	Rheumatoid arthritis_Homo sapiens_hsa05323	0.44496845
88	Legionellosis_Homo sapiens_hsa05134	0.44043331
89	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41790588
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.40933522
91	Alcoholism_Homo sapiens_hsa05034	0.40013255
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38129448
93	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.36991322
94	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.36935263
95	Allograft rejection_Homo sapiens_hsa05330	0.36266283
96	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.35719383
97	ABC transporters_Homo sapiens_hsa02010	0.35042909
98	Fatty acid degradation_Homo sapiens_hsa00071	0.32735099
99	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.30570803
100	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.28834421

ZNF140

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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