ZNF141

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replication fork processing (GO:0031297)4.87790043
2behavioral response to nicotine (GO:0035095)4.03863932
3negative regulation of translation, ncRNA-mediated (GO:0040033)3.85882868
4regulation of translation, ncRNA-mediated (GO:0045974)3.85882868
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.85882868
6DNA double-strand break processing (GO:0000729)3.81462821
7neural tube formation (GO:0001841)3.69730588
8pyrimidine nucleobase catabolic process (GO:0006208)3.64236710
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.58097978
10RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.55592253
11L-fucose metabolic process (GO:0042354)3.50199433
12L-fucose catabolic process (GO:0042355)3.50199433
13fucose catabolic process (GO:0019317)3.50199433
14regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.35133870
15regulation of mitotic spindle checkpoint (GO:1903504)3.35133870
16negative regulation of DNA-dependent DNA replication (GO:2000104)3.34224820
17centriole replication (GO:0007099)3.24468469
18somatic hypermutation of immunoglobulin genes (GO:0016446)3.24090658
19somatic diversification of immune receptors via somatic mutation (GO:0002566)3.24090658
20response to pheromone (GO:0019236)3.22763405
21cellular ketone body metabolic process (GO:0046950)3.22242952
22intraciliary transport (GO:0042073)3.12681105
23synapsis (GO:0007129)3.08988061
24positive regulation of histone H3-K4 methylation (GO:0051571)3.07685718
25reciprocal meiotic recombination (GO:0007131)3.07504547
26reciprocal DNA recombination (GO:0035825)3.07504547
27epithelial cilium movement (GO:0003351)3.05916491
28double-strand break repair via homologous recombination (GO:0000724)3.01844238
29recombinational repair (GO:0000725)3.01556251
30photoreceptor cell maintenance (GO:0045494)3.01332078
31platelet dense granule organization (GO:0060155)3.01273442
32respiratory chain complex IV assembly (GO:0008535)3.00287079
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.96750350
34nucleobase catabolic process (GO:0046113)2.96441201
35axoneme assembly (GO:0035082)2.93479829
36indolalkylamine metabolic process (GO:0006586)2.91907992
37histone mRNA catabolic process (GO:0071044)2.91438829
38ketone body metabolic process (GO:1902224)2.91242869
39response to UV-C (GO:0010225)2.88141276
40regulation of meiosis I (GO:0060631)2.82573533
41peptidyl-histidine modification (GO:0018202)2.82272319
42protein complex biogenesis (GO:0070271)2.82001584
43histone H2A acetylation (GO:0043968)2.81287584
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.78766726
45tryptophan catabolic process (GO:0006569)2.75605393
46indole-containing compound catabolic process (GO:0042436)2.75605393
47indolalkylamine catabolic process (GO:0046218)2.75605393
48postreplication repair (GO:0006301)2.75004485
49mitochondrial respiratory chain complex assembly (GO:0033108)2.70613451
50regulation of posttranscriptional gene silencing (GO:0060147)2.69295258
51regulation of gene silencing by miRNA (GO:0060964)2.69295258
52regulation of gene silencing by RNA (GO:0060966)2.69295258
53cytochrome complex assembly (GO:0017004)2.68182474
54negative regulation of DNA recombination (GO:0045910)2.67624946
55water-soluble vitamin biosynthetic process (GO:0042364)2.67483547
56male meiosis I (GO:0007141)2.64406552
57regulation of centriole replication (GO:0046599)2.63864383
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63284069
59rRNA catabolic process (GO:0016075)2.62822905
60DNA deamination (GO:0045006)2.62741368
61retinal cone cell development (GO:0046549)2.62369287
62ubiquinone biosynthetic process (GO:0006744)2.61957155
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61225045
64cilium organization (GO:0044782)2.60836965
65ubiquinone metabolic process (GO:0006743)2.60596795
66preassembly of GPI anchor in ER membrane (GO:0016254)2.59715587
67protein localization to cilium (GO:0061512)2.58856336
68protein K11-linked deubiquitination (GO:0035871)2.58247163
69tryptophan metabolic process (GO:0006568)2.57788872
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.57138134
71mitochondrial respiratory chain complex I assembly (GO:0032981)2.57138134
72NADH dehydrogenase complex assembly (GO:0010257)2.57138134
73piRNA metabolic process (GO:0034587)2.56449047
74reflex (GO:0060004)2.56047927
75protein polyglutamylation (GO:0018095)2.55733746
76tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55504803
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55504803
78cilium assembly (GO:0042384)2.52928187
79kynurenine metabolic process (GO:0070189)2.50973658
80protein K6-linked ubiquitination (GO:0085020)2.49480353
81somite development (GO:0061053)2.49174977
82dopamine transport (GO:0015872)2.48632831
83ncRNA catabolic process (GO:0034661)2.47524972
84microtubule anchoring (GO:0034453)2.46867390
85histone mRNA metabolic process (GO:0008334)2.45792736
86limb bud formation (GO:0060174)2.45660530
87mannosylation (GO:0097502)2.44503288
88DNA integration (GO:0015074)2.43424603
89cilium morphogenesis (GO:0060271)2.42743905
90establishment of protein localization to Golgi (GO:0072600)2.41979497
91regulation of telomere maintenance (GO:0032204)2.40120185
92cilium movement (GO:0003341)2.39255359
93regulation of nuclear cell cycle DNA replication (GO:0033262)2.39225165
94kidney morphogenesis (GO:0060993)2.37474614
95prenylation (GO:0097354)2.37213101
96protein prenylation (GO:0018342)2.37213101
97DNA demethylation (GO:0080111)2.36417680
98inositol phosphate catabolic process (GO:0071545)2.36197102
99spinal cord motor neuron differentiation (GO:0021522)2.35053444
100regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.34039530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.68736404
2SALL1_21062744_ChIP-ChIP_HESCs_Human2.82119767
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.81504879
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68610809
5GBX2_23144817_ChIP-Seq_PC3_Human2.66888313
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60049496
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.52819966
8VDR_22108803_ChIP-Seq_LS180_Human2.52008766
9IGF1R_20145208_ChIP-Seq_DFB_Human2.49219098
10FUS_26573619_Chip-Seq_HEK293_Human2.49186617
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41665428
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39487881
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35947253
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33119844
15EWS_26573619_Chip-Seq_HEK293_Human2.22978711
16TAF15_26573619_Chip-Seq_HEK293_Human2.19692602
17P300_19829295_ChIP-Seq_ESCs_Human2.16398002
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01642719
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99505410
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98676179
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95548827
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92434022
23ER_23166858_ChIP-Seq_MCF-7_Human1.86698722
24IRF1_19129219_ChIP-ChIP_H3396_Human1.86673340
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80529258
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77586815
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77498301
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.67436836
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.66693256
30ELK1_19687146_ChIP-ChIP_HELA_Human1.66332880
31EZH2_22144423_ChIP-Seq_EOC_Human1.66268469
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63583850
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.61263421
34STAT3_23295773_ChIP-Seq_U87_Human1.58315566
35SMAD4_21799915_ChIP-Seq_A2780_Human1.56248065
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55827045
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54933837
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.54648568
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49567517
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49567517
41BCAT_22108803_ChIP-Seq_LS180_Human1.48372403
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48060489
43CBP_20019798_ChIP-Seq_JUKART_Human1.48060489
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47442833
45TCF4_23295773_ChIP-Seq_U87_Human1.46211559
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45887421
47AR_25329375_ChIP-Seq_VCAP_Human1.45804788
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45110709
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.44068399
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.41897430
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39988895
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.39100827
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36628950
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.35495983
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35436481
56TP53_22573176_ChIP-Seq_HFKS_Human1.34738157
57* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34690326
58* VDR_23849224_ChIP-Seq_CD4+_Human1.33655261
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33362075
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33356780
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32868124
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30883937
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29623447
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28744245
65MYC_18940864_ChIP-ChIP_HL60_Human1.28469706
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28244929
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.27493814
68TCF4_22108803_ChIP-Seq_LS180_Human1.26971138
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25297018
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24643735
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23054666
72SOX2_19829295_ChIP-Seq_ESCs_Human1.22597557
73NANOG_19829295_ChIP-Seq_ESCs_Human1.22597557
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21696465
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19583826
76RUNX2_22187159_ChIP-Seq_PCA_Human1.19257538
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16961139
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.15053347
79FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15053347
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13832366
81P53_22387025_ChIP-Seq_ESCs_Mouse1.13489175
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.11323457
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.09506873
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.07640189
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.05449348
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05005508
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04782815
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.04447385
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04443079
90RNF2_27304074_Chip-Seq_NSC_Mouse1.02439774
91P300_18555785_Chip-Seq_ESCs_Mouse1.00572233
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00014061
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99887962
94STAT3_18555785_Chip-Seq_ESCs_Mouse0.99789155
95CMYC_18555785_Chip-Seq_ESCs_Mouse0.98305766
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97967181
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97109463
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.96652694
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.96427961
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94967914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.72583379
2MP0008057_abnormal_DNA_replication3.32354812
3MP0006292_abnormal_olfactory_placode2.81435715
4MP0000569_abnormal_digit_pigmentation2.79966462
5MP0004147_increased_porphyrin_level2.67652162
6MP0003787_abnormal_imprinting2.47612825
7MP0008058_abnormal_DNA_repair2.43100111
8MP0006072_abnormal_retinal_apoptosis2.42514345
9MP0003880_abnormal_central_pattern2.36904103
10MP0003195_calcinosis2.34797770
11MP0002638_abnormal_pupillary_reflex2.25908155
12MP0002102_abnormal_ear_morphology2.24624789
13MP0005645_abnormal_hypothalamus_physiol1.91815277
14MP0005551_abnormal_eye_electrophysiolog1.87651568
15MP0001986_abnormal_taste_sensitivity1.85385529
16MP0005253_abnormal_eye_physiology1.85383362
17MP0000427_abnormal_hair_cycle1.79546543
18MP0003890_abnormal_embryonic-extraembry1.76523197
19MP0010094_abnormal_chromosome_stability1.76024189
20MP0005646_abnormal_pituitary_gland1.75583428
21MP0001529_abnormal_vocalization1.75298582
22MP0008995_early_reproductive_senescence1.74098655
23MP0002009_preneoplasia1.73477671
24MP0003121_genomic_imprinting1.67481391
25MP0001984_abnormal_olfaction1.64025972
26MP0000631_abnormal_neuroendocrine_gland1.61679898
27MP0006276_abnormal_autonomic_nervous1.60808332
28MP0005075_abnormal_melanosome_morpholog1.57651925
29MP0001968_abnormal_touch/_nociception1.56687970
30MP0009046_muscle_twitch1.47868303
31MP0008872_abnormal_physiological_respon1.46066868
32MP0000372_irregular_coat_pigmentation1.40952715
33MP0002938_white_spotting1.39489607
34MP0000383_abnormal_hair_follicle1.37134567
35MP0002837_dystrophic_cardiac_calcinosis1.36111970
36MP0002751_abnormal_autonomic_nervous1.34558841
37MP0001485_abnormal_pinna_reflex1.27394670
38MP0004133_heterotaxia1.26979309
39MP0002163_abnormal_gland_morphology1.23399622
40MP0001486_abnormal_startle_reflex1.23141170
41MP0004142_abnormal_muscle_tone1.22678899
42MP0003718_maternal_effect1.22050396
43MP0009745_abnormal_behavioral_response1.21594760
44MP0008789_abnormal_olfactory_epithelium1.20548048
45MP0005084_abnormal_gallbladder_morpholo1.19123140
46MP0003646_muscle_fatigue1.18371739
47MP0003122_maternal_imprinting1.18352776
48MP0003136_yellow_coat_color1.16168427
49MP0004145_abnormal_muscle_electrophysio1.14765764
50MP0001501_abnormal_sleep_pattern1.13610977
51MP0005379_endocrine/exocrine_gland_phen1.13150388
52MP0010386_abnormal_urinary_bladder1.09777120
53MP0008775_abnormal_heart_ventricle1.07015156
54MP0002272_abnormal_nervous_system1.07009223
55MP0009697_abnormal_copulation1.06656228
56MP0000647_abnormal_sebaceous_gland1.06050856
57MP0001293_anophthalmia1.05406573
58MP0001929_abnormal_gametogenesis1.04885541
59MP0005389_reproductive_system_phenotype1.04124704
60MP0005499_abnormal_olfactory_system1.02678910
61MP0005394_taste/olfaction_phenotype1.02678910
62MP0002736_abnormal_nociception_after1.02171805
63MP0001919_abnormal_reproductive_system1.02072902
64MP0002557_abnormal_social/conspecific_i0.99791650
65MP0004885_abnormal_endolymph0.99520067
66MP0002160_abnormal_reproductive_system0.99176382
67MP0002909_abnormal_adrenal_gland0.98938135
68MP0003937_abnormal_limbs/digits/tail_de0.98019712
69MP0003786_premature_aging0.95604754
70MP0002876_abnormal_thyroid_physiology0.94313794
71MP0002067_abnormal_sensory_capabilities0.94243034
72MP0003698_abnormal_male_reproductive0.92203042
73MP0005187_abnormal_penis_morphology0.91844430
74MP0000778_abnormal_nervous_system0.90067011
75MP0002210_abnormal_sex_determination0.89389309
76MP0003119_abnormal_digestive_system0.89136178
77MP0005386_behavior/neurological_phenoty0.89040471
78MP0004924_abnormal_behavior0.89040471
79MP0010678_abnormal_skin_adnexa0.88990938
80MP0002735_abnormal_chemical_nociception0.88747430
81MP0004215_abnormal_myocardial_fiber0.88447277
82MP0005195_abnormal_posterior_eye0.86271195
83MP0005174_abnormal_tail_pigmentation0.85129948
84MP0005391_vision/eye_phenotype0.82810413
85MP0000653_abnormal_sex_gland0.82615297
86MP0005248_abnormal_Harderian_gland0.81749807
87MP0002733_abnormal_thermal_nociception0.79986144
88MP0001145_abnormal_male_reproductive0.79479677
89MP0001324_abnormal_eye_pigmentation0.79443145
90MP0006035_abnormal_mitochondrial_morpho0.78483628
91MP0005167_abnormal_blood-brain_barrier0.78332148
92MP0005266_abnormal_metabolism0.78035366
93MP0002572_abnormal_emotion/affect_behav0.77882657
94MP0001286_abnormal_eye_development0.75241160
95MP0004043_abnormal_pH_regulation0.74775853
96MP0001764_abnormal_homeostasis0.73507432
97MP0002184_abnormal_innervation0.72838877
98MP0001188_hyperpigmentation0.72555576
99MP0001970_abnormal_pain_threshold0.72471358
100MP0002752_abnormal_somatic_nervous0.71854557

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.72062915
2Nephronophthisis (HP:0000090)3.45942787
3Molar tooth sign on MRI (HP:0002419)3.22734080
4Abnormality of midbrain morphology (HP:0002418)3.22734080
5Abnormality of the labia minora (HP:0012880)3.17056329
6Abnormality of the renal medulla (HP:0100957)3.10712728
7Pancreatic fibrosis (HP:0100732)3.07739779
8Abnormality of the renal cortex (HP:0011035)3.04575387
9Medial flaring of the eyebrow (HP:0010747)3.01225240
10True hermaphroditism (HP:0010459)2.96156117
11Gaze-evoked nystagmus (HP:0000640)2.89322842
12Colon cancer (HP:0003003)2.79957267
13Hyperventilation (HP:0002883)2.75071473
14Congenital stationary night blindness (HP:0007642)2.73690482
15Chronic hepatic failure (HP:0100626)2.72668764
16Renal cortical cysts (HP:0000803)2.64877704
17Abolished electroretinogram (ERG) (HP:0000550)2.62970842
18Abnormal hair whorl (HP:0010721)2.60468609
19Tubulointerstitial nephritis (HP:0001970)2.58617215
20Congenital primary aphakia (HP:0007707)2.44613369
21Gait imbalance (HP:0002141)2.44138849
22Degeneration of the lateral corticospinal tracts (HP:0002314)2.39011692
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39011692
24Progressive inability to walk (HP:0002505)2.38863203
25Abnormality of chromosome stability (HP:0003220)2.37289479
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.37021708
27Intestinal atresia (HP:0011100)2.31193074
28Tubular atrophy (HP:0000092)2.30819751
29Genital tract atresia (HP:0001827)2.30727567
30Fair hair (HP:0002286)2.28865275
31Nephrogenic diabetes insipidus (HP:0009806)2.28361164
32Attenuation of retinal blood vessels (HP:0007843)2.27677199
33Hypothermia (HP:0002045)2.27062884
34Oligodactyly (hands) (HP:0001180)2.26946751
35Thyroiditis (HP:0100646)2.22329718
36Vaginal atresia (HP:0000148)2.20682341
37Abnormality of macular pigmentation (HP:0008002)2.16203740
38Broad-based gait (HP:0002136)2.12196881
39Methylmalonic acidemia (HP:0002912)2.08689857
40Meckel diverticulum (HP:0002245)2.08080723
41Abnormality of the ileum (HP:0001549)2.06977928
42Lissencephaly (HP:0001339)2.05828155
43Stomach cancer (HP:0012126)2.04955829
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04454493
45Volvulus (HP:0002580)2.04104799
46Chromsome breakage (HP:0040012)2.03371999
47Inability to walk (HP:0002540)2.03322065
48Neoplasm of the oral cavity (HP:0100649)2.03097807
49Pendular nystagmus (HP:0012043)2.00184945
50Optic nerve hypoplasia (HP:0000609)1.95297872
51Type II lissencephaly (HP:0007260)1.95224789
52Abnormal biliary tract physiology (HP:0012439)1.92318218
53Bile duct proliferation (HP:0001408)1.92318218
54Azoospermia (HP:0000027)1.88942594
55Clubbing of toes (HP:0100760)1.87161945
56Aplasia/Hypoplasia of the tongue (HP:0010295)1.86562357
57Protruding tongue (HP:0010808)1.86063268
58Sloping forehead (HP:0000340)1.85012700
59Methylmalonic aciduria (HP:0012120)1.84772577
60Progressive cerebellar ataxia (HP:0002073)1.83605521
61Congenital hepatic fibrosis (HP:0002612)1.83430025
62Hyperglycinemia (HP:0002154)1.83300009
63Growth hormone deficiency (HP:0000824)1.80245888
64Cystic liver disease (HP:0006706)1.79251126
65Lipid accumulation in hepatocytes (HP:0006561)1.78663493
66Birth length less than 3rd percentile (HP:0003561)1.77857158
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77312419
68Tubulointerstitial abnormality (HP:0001969)1.76742242
69Abnormal drinking behavior (HP:0030082)1.75614502
70Polydipsia (HP:0001959)1.75614502
71Poor coordination (HP:0002370)1.73720004
72Postaxial hand polydactyly (HP:0001162)1.72575571
73Abnormality of the corticospinal tract (HP:0002492)1.71789675
74Cerebellar dysplasia (HP:0007033)1.71785159
75Pachygyria (HP:0001302)1.71654135
76Abnormal spermatogenesis (HP:0008669)1.69750936
77Patellar aplasia (HP:0006443)1.69320596
78Postaxial foot polydactyly (HP:0001830)1.68760480
79Neoplasm of the adrenal cortex (HP:0100641)1.68371900
80Aplasia/Hypoplasia of the tibia (HP:0005772)1.67178878
81Astigmatism (HP:0000483)1.65736285
82Septo-optic dysplasia (HP:0100842)1.62298120
83Specific learning disability (HP:0001328)1.62287806
84Drooling (HP:0002307)1.61185046
85Progressive macrocephaly (HP:0004481)1.60778065
86Decreased central vision (HP:0007663)1.60127179
87Abnormal rod and cone electroretinograms (HP:0008323)1.59841964
88Acute encephalopathy (HP:0006846)1.59417845
89Generalized hypopigmentation of hair (HP:0011358)1.58920339
90Increased CSF lactate (HP:0002490)1.58416760
91Mitochondrial inheritance (HP:0001427)1.57886420
92Supernumerary spleens (HP:0009799)1.57723313
93Increased hepatocellular lipid droplets (HP:0006565)1.56353032
94Acute necrotizing encephalopathy (HP:0006965)1.55731237
95Abnormality of the duodenum (HP:0002246)1.55631747
96Aplasia/Hypoplasia of the patella (HP:0006498)1.55272683
97Dialeptic seizures (HP:0011146)1.54038096
98Widely spaced teeth (HP:0000687)1.53821506
99Abnormality of DNA repair (HP:0003254)1.53622238
100Sclerocornea (HP:0000647)1.52991526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.82456929
2BMPR1B3.50645471
3WNK32.72972136
4MKNK22.66162090
5MAP4K22.57807804
6MAP3K42.54998166
7ZAK2.47446945
8NUAK12.43672490
9CASK2.32610439
10ACVR1B2.14496622
11ADRBK22.09821396
12TNIK1.99261064
13PINK11.80345810
14MKNK11.78001014
15GRK11.74170427
16AKT31.69299241
17PLK41.67408407
18MAPK131.65814049
19STK38L1.56177993
20TGFBR11.52501648
21TRIM281.49685636
22SRPK11.43234768
23INSRR1.41954744
24VRK11.41432322
25NLK1.34187931
26MAP2K71.33490207
27FGFR21.30818816
28CSNK1G11.27012116
29ERBB31.26763755
30CDC71.26617981
31PLK21.15423054
32MUSK1.14776563
33MST41.12354666
34CSNK1G21.12021183
35PLK31.11182511
36OXSR11.07071044
37TLK11.05932444
38CSNK1G31.03215414
39EPHA41.03081280
40BRSK20.99550320
41PAK30.95917462
42TEC0.94440938
43TAOK30.92142027
44PRKCE0.88212039
45DYRK20.86013354
46BCR0.85419835
47SGK20.82449298
48TXK0.74919978
49STK390.72408882
50TAF10.72378798
51ADRBK10.72285641
52CSNK1A1L0.71921229
53TSSK60.70510842
54FLT30.69718151
55ATM0.67831539
56EIF2AK30.67802458
57PIK3CG0.66854924
58STK30.65906899
59ATR0.65873390
60OBSCN0.64964231
61PLK10.64070635
62CDK80.63870093
63MARK10.63599274
64WNK40.62670276
65PRKCG0.60618048
66BCKDK0.57933672
67PNCK0.57135877
68TNK20.56558103
69BRD40.55545382
70DYRK30.53581793
71CDK30.53084552
72PBK0.52980061
73SGK2230.51203493
74SGK4940.51203493
75KIT0.50838434
76WEE10.50217030
77CSNK1A10.49288728
78CSNK1D0.47781818
79DAPK20.46697278
80DYRK1A0.44916923
81MAP2K40.43259033
82STK40.42849838
83PKN10.41750841
84TIE10.40378728
85CHEK20.39565148
86PIK3CA0.37519025
87FER0.37173305
88ITK0.37007434
89CHUK0.36102927
90RPS6KA50.34606987
91STK110.33381179
92PRKCQ0.32696762
93TTK0.31977636
94PRKG10.31769959
95CAMK1G0.30867671
96CAMKK20.30570514
97PTK2B0.30224459
98CAMK2A0.30013153
99PRKACB0.28038459
100VRK20.27205401

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.14794982
2Non-homologous end-joining_Homo sapiens_hsa034503.02360369
3Homologous recombination_Homo sapiens_hsa034402.80533066
4Protein export_Homo sapiens_hsa030602.69179944
5Fanconi anemia pathway_Homo sapiens_hsa034602.67770778
6Butanoate metabolism_Homo sapiens_hsa006502.59536396
7Basal transcription factors_Homo sapiens_hsa030222.36285057
8Phototransduction_Homo sapiens_hsa047442.34045351
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28397519
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.24583881
11RNA polymerase_Homo sapiens_hsa030202.18594636
12Propanoate metabolism_Homo sapiens_hsa006402.14199496
13RNA degradation_Homo sapiens_hsa030182.04182643
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96169138
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79870363
16Nicotine addiction_Homo sapiens_hsa050331.79114329
17Nitrogen metabolism_Homo sapiens_hsa009101.72316190
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71736473
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69433411
20Selenocompound metabolism_Homo sapiens_hsa004501.68871021
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49237569
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47957146
23Linoleic acid metabolism_Homo sapiens_hsa005911.45001817
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41851710
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41807254
26Oxidative phosphorylation_Homo sapiens_hsa001901.39207746
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.38293413
28Mismatch repair_Homo sapiens_hsa034301.37718122
29Peroxisome_Homo sapiens_hsa041461.35550227
30Taste transduction_Homo sapiens_hsa047421.32876530
31Ether lipid metabolism_Homo sapiens_hsa005651.26487625
32Tryptophan metabolism_Homo sapiens_hsa003801.22734081
33Nucleotide excision repair_Homo sapiens_hsa034201.20289493
34Base excision repair_Homo sapiens_hsa034101.17140990
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13609206
36Parkinsons disease_Homo sapiens_hsa050121.08230293
37One carbon pool by folate_Homo sapiens_hsa006701.04035046
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.03774084
39Caffeine metabolism_Homo sapiens_hsa002321.03773529
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99003894
41Olfactory transduction_Homo sapiens_hsa047400.98830564
42Steroid biosynthesis_Homo sapiens_hsa001000.95776363
43Purine metabolism_Homo sapiens_hsa002300.95399217
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91288314
45Asthma_Homo sapiens_hsa053100.90105115
46Insulin secretion_Homo sapiens_hsa049110.86597768
47RNA transport_Homo sapiens_hsa030130.86271015
48Systemic lupus erythematosus_Homo sapiens_hsa053220.84155097
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.83880760
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83756851
51GABAergic synapse_Homo sapiens_hsa047270.81751499
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.81561913
53Regulation of autophagy_Homo sapiens_hsa041400.80355009
54Morphine addiction_Homo sapiens_hsa050320.79524015
55Serotonergic synapse_Homo sapiens_hsa047260.79273299
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78142673
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77148286
58Primary immunodeficiency_Homo sapiens_hsa053400.77095770
59Huntingtons disease_Homo sapiens_hsa050160.76694100
60Retinol metabolism_Homo sapiens_hsa008300.76588419
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75703012
62Proteasome_Homo sapiens_hsa030500.74783170
63Type I diabetes mellitus_Homo sapiens_hsa049400.73682379
64ABC transporters_Homo sapiens_hsa020100.72582238
65Circadian entrainment_Homo sapiens_hsa047130.71134745
66Glutamatergic synapse_Homo sapiens_hsa047240.70360742
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69786465
68DNA replication_Homo sapiens_hsa030300.69621091
69Pyrimidine metabolism_Homo sapiens_hsa002400.68511497
70beta-Alanine metabolism_Homo sapiens_hsa004100.66896013
71Spliceosome_Homo sapiens_hsa030400.59861380
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59614569
73Chemical carcinogenesis_Homo sapiens_hsa052040.59201086
74Graft-versus-host disease_Homo sapiens_hsa053320.58719507
75mRNA surveillance pathway_Homo sapiens_hsa030150.56895681
76Alcoholism_Homo sapiens_hsa050340.56501982
77Dorso-ventral axis formation_Homo sapiens_hsa043200.54903156
78Dopaminergic synapse_Homo sapiens_hsa047280.54733311
79Hedgehog signaling pathway_Homo sapiens_hsa043400.53325375
80Collecting duct acid secretion_Homo sapiens_hsa049660.53063638
81Metabolic pathways_Homo sapiens_hsa011000.52459880
82Oocyte meiosis_Homo sapiens_hsa041140.52421673
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.51618111
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50130477
85Ovarian steroidogenesis_Homo sapiens_hsa049130.49864954
86Circadian rhythm_Homo sapiens_hsa047100.48681252
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47533559
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46832966
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46786393
90Arachidonic acid metabolism_Homo sapiens_hsa005900.46463281
91Cell cycle_Homo sapiens_hsa041100.46102501
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43298360
93Calcium signaling pathway_Homo sapiens_hsa040200.42872511
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42427972
95Autoimmune thyroid disease_Homo sapiens_hsa053200.40538631
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40258317
97Alzheimers disease_Homo sapiens_hsa050100.39732913
98Glycerolipid metabolism_Homo sapiens_hsa005610.38641182
99p53 signaling pathway_Homo sapiens_hsa041150.38154539
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37260489

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