ZNF142

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activation of MAPKKK activity (GO:0000185)8.60225527
2leukocyte aggregation (GO:0070486)6.97566784
3rRNA transcription (GO:0009303)5.98869631
4positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.53918180
5mitotic chromosome condensation (GO:0007076)4.36667790
6negative regulation of cell size (GO:0045792)4.11675497
7mitotic sister chromatid cohesion (GO:0007064)4.06347099
8histone H3-K4 methylation (GO:0051568)3.99514472
9positive regulation of signal transduction by p53 class mediator (GO:1901798)3.91624496
10regulation of chromatin binding (GO:0035561)3.71841542
11histone H4 deacetylation (GO:0070933)3.64282057
12glycoprotein catabolic process (GO:0006516)3.61327134
13histone H4-K16 acetylation (GO:0043984)3.52941153
14regulation of histone H3-K27 methylation (GO:0061085)3.52784450
15positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.49314224
16hematopoietic stem cell differentiation (GO:0060218)3.48871761
17regulation of NFAT protein import into nucleus (GO:0051532)3.46247883
18meiotic chromosome segregation (GO:0045132)3.38759438
19DNA unwinding involved in DNA replication (GO:0006268)3.34992946
20negative regulation of histone methylation (GO:0031061)3.34581370
21regulation of RNA export from nucleus (GO:0046831)3.31691707
22positive regulation of gene expression, epigenetic (GO:0045815)3.30512748
23erythrocyte maturation (GO:0043249)3.30215306
24DNA duplex unwinding (GO:0032508)3.23964572
253-UTR-mediated mRNA stabilization (GO:0070935)3.22020897
26histone H3-K4 trimethylation (GO:0080182)3.21762926
27positive regulation of histone deacetylation (GO:0031065)3.21143802
28spliceosomal tri-snRNP complex assembly (GO:0000244)3.19310559
29positive regulation of DNA-dependent DNA replication (GO:2000105)3.16603923
30positive regulation of vascular permeability (GO:0043117)3.13760190
31macroautophagy (GO:0016236)3.13148423
32histone H3-K36 demethylation (GO:0070544)3.11881456
33intracellular estrogen receptor signaling pathway (GO:0030520)3.05758681
34regulation of nucleobase-containing compound transport (GO:0032239)3.05693182
35nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.05058077
36chromatin silencing (GO:0006342)3.04500255
37histone H3 deacetylation (GO:0070932)3.03759383
38positive regulation of protein deacetylation (GO:0090312)3.03564644
39histone lysine methylation (GO:0034968)3.00587369
40mitotic sister chromatid segregation (GO:0000070)2.99811356
41DNA geometric change (GO:0032392)2.99014993
42determination of adult lifespan (GO:0008340)2.95452766
43histone H4-K5 acetylation (GO:0043981)2.95048076
44histone H4-K8 acetylation (GO:0043982)2.95048076
45positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.93685332
46atrial septum morphogenesis (GO:0060413)2.93031451
47histone H3 acetylation (GO:0043966)2.88555990
48histone acetylation (GO:0016573)2.81917488
49RNA stabilization (GO:0043489)2.80464875
50mRNA stabilization (GO:0048255)2.80464875
51negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.80373683
52nuclear pore complex assembly (GO:0051292)2.79995899
53heterochromatin organization (GO:0070828)2.79274511
54regulation of protein deacetylation (GO:0090311)2.77743239
55maintenance of protein location in nucleus (GO:0051457)2.77600550
56adherens junction assembly (GO:0034333)2.77138802
57heart morphogenesis (GO:0003007)2.77047554
58regulation of histone H3-K4 methylation (GO:0051569)2.76619676
59cellular protein complex localization (GO:0034629)2.74651922
60negative regulation of viral release from host cell (GO:1902187)2.74414821
61histone H4 acetylation (GO:0043967)2.73951746
62cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.73878966
63peptidyl-threonine phosphorylation (GO:0018107)2.71441801
64negative regulation of mRNA metabolic process (GO:1903312)2.70230376
65snRNA metabolic process (GO:0016073)2.69438963
66internal peptidyl-lysine acetylation (GO:0018393)2.69231889
67regulation of mammary gland epithelial cell proliferation (GO:0033599)2.68022240
68sister chromatid segregation (GO:0000819)2.67125442
69DNA conformation change (GO:0071103)2.66496099
70UV protection (GO:0009650)2.65694138
71DNA replication initiation (GO:0006270)2.65093599
72histone deacetylation (GO:0016575)2.64694646
73SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.64564128
74positive regulation of CREB transcription factor activity (GO:0032793)2.63571806
75protein deacetylation (GO:0006476)2.63311861
76focal adhesion assembly (GO:0048041)2.62694920
77cell-substrate adherens junction assembly (GO:0007045)2.62694920
78glucocorticoid receptor signaling pathway (GO:0042921)2.62600419
79TOR signaling (GO:0031929)2.61852856
80peptidyl-lysine acetylation (GO:0018394)2.59209267
81NIK/NF-kappaB signaling (GO:0038061)2.59131479
82mannose metabolic process (GO:0006013)2.58618589
83DNA alkylation (GO:0006305)2.58303127
84DNA methylation (GO:0006306)2.58303127
85histone methylation (GO:0016571)2.57814895
86negative regulation of histone modification (GO:0031057)2.56991496
87positive regulation of cell size (GO:0045793)2.54665271
88regulation of histone methylation (GO:0031060)2.52907167
89N-terminal protein amino acid acetylation (GO:0006474)2.52110904
90thymic T cell selection (GO:0045061)2.51391919
91regulation of histone deacetylation (GO:0031063)2.51069072
92internal protein amino acid acetylation (GO:0006475)2.50681045
93apoptotic process involved in morphogenesis (GO:0060561)2.49386752
94histone deubiquitination (GO:0016578)2.48585342
95negative regulation of erythrocyte differentiation (GO:0045647)2.47475700
96pre-miRNA processing (GO:0031054)2.47356530
97regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.46537022
98gene silencing (GO:0016458)2.46110586
99activation of Rac GTPase activity (GO:0032863)2.44766867
100regulation of cell size (GO:0008361)2.43252538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.82469886
2MYC_22102868_ChIP-Seq_BL_Human4.40899179
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.39908145
4VDR_21846776_ChIP-Seq_THP-1_Human3.04304002
5TCF7_22412390_ChIP-Seq_EML_Mouse2.83780481
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.82394372
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.76301024
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.67391722
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.58965071
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56976488
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.48537735
12KDM2B_26808549_Chip-Seq_DND41_Human2.43717365
13KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.41084959
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30639639
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21585003
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.18634219
17LXR_22292898_ChIP-Seq_THP-1_Human2.14138722
18CIITA_25753668_ChIP-Seq_RAJI_Human1.98532625
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94504223
20CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.92165663
21MAF_26560356_Chip-Seq_TH1_Human1.90971645
22RACK7_27058665_Chip-Seq_MCF-7_Human1.90561465
23KDM2B_26808549_Chip-Seq_JURKAT_Human1.83925487
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.81713753
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75392978
26MAF_26560356_Chip-Seq_TH2_Human1.74153413
27UTX_26944678_Chip-Seq_JUKART_Human1.69037884
28P68_20966046_ChIP-Seq_HELA_Human1.68421450
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68020707
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.66654594
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62638567
32CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.60156327
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55839157
34KDM5A_27292631_Chip-Seq_BREAST_Human1.53562917
35KDM2B_26808549_Chip-Seq_K562_Human1.50022802
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47636249
37SMC4_20622854_ChIP-Seq_HELA_Human1.46915600
38P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45606391
39VDR_24763502_ChIP-Seq_THP-1_Human1.45456764
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44478579
41SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.43766304
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43732713
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.41219647
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.37972911
45GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37527306
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34904332
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33716171
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29531513
49CREB1_26743006_Chip-Seq_LNCaP_Human1.27977348
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.26090026
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25142533
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23487541
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23041874
54ETS1_21867929_ChIP-Seq_TH2_Mouse1.21949879
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.20857985
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20518079
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19536003
58NCOR1_26117541_ChIP-Seq_K562_Human1.19017429
59PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18580640
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18182371
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18055831
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.17100488
63* E2F1_21310950_ChIP-Seq_MCF-7_Human1.16415041
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.16364359
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15725752
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.15501581
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14572630
68TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13821477
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12337982
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11975906
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11551589
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11338157
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08893434
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08737349
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07207760
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07195776
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.06695133
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06443761
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06084683
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05216652
81MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04532828
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04266774
83XRN2_22483619_ChIP-Seq_HELA_Human1.04035139
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04020243
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03501500
86ZNF263_19887448_ChIP-Seq_K562_Human1.03416430
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02627749
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01898547
89OCT4_19829295_ChIP-Seq_ESCs_Human1.01405393
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.00513742
91MYB_26560356_Chip-Seq_TH2_Human1.00480802
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00398559
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99941060
94TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99615376
95MYB_26560356_Chip-Seq_TH1_Human0.98858095
96CHD1_26751641_Chip-Seq_LNCaP_Human0.97214163
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96649723
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96315741
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94664867
100BCOR_27268052_Chip-Seq_Bcells_Human0.94200688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology6.24922813
2MP0005076_abnormal_cell_differentiation3.58852970
3MP0002396_abnormal_hematopoietic_system3.14293066
4MP0003705_abnormal_hypodermis_morpholog3.07967850
5MP0003763_abnormal_thymus_physiology2.92560800
6MP0010094_abnormal_chromosome_stability2.86112887
7MP0000750_abnormal_muscle_regeneration2.74659244
8MP0008057_abnormal_DNA_replication2.73209481
9MP0000013_abnormal_adipose_tissue2.61489311
10MP0004233_abnormal_muscle_weight2.37194117
11MP0003111_abnormal_nucleus_morphology2.35778104
12MP0010307_abnormal_tumor_latency2.23396532
13MP0004947_skin_inflammation2.20611557
14MP0000003_abnormal_adipose_tissue1.96103193
15MP0003786_premature_aging1.90318606
16MP0010352_gastrointestinal_tract_polyps1.83311510
17MP0003693_abnormal_embryo_hatching1.82458709
18MP0008260_abnormal_autophagy1.75199468
19MP0001730_embryonic_growth_arrest1.71168380
20MP0000858_altered_metastatic_potential1.70751377
21MP0003077_abnormal_cell_cycle1.66530127
22MP0008058_abnormal_DNA_repair1.65852473
23MP0005621_abnormal_cell_physiology1.61140568
24MP0009384_cardiac_valve_regurgitation1.60586467
25MP0000703_abnormal_thymus_morphology1.57319304
26MP0000350_abnormal_cell_proliferation1.47397276
27MP0002009_preneoplasia1.46722448
28MP0002249_abnormal_larynx_morphology1.38969939
29MP0005451_abnormal_body_composition1.38385995
30MP0004808_abnormal_hematopoietic_stem1.36912346
31MP0002089_abnormal_postnatal_growth/wei1.33905705
32MP0003115_abnormal_respiratory_system1.31106353
33MP0009333_abnormal_splenocyte_physiolog1.30899399
34MP0004087_abnormal_muscle_fiber1.27964361
35MP0003566_abnormal_cell_adhesion1.27854869
36MP0009278_abnormal_bone_marrow1.27707969
37MP0004197_abnormal_fetal_growth/weight/1.24397793
38MP0004858_abnormal_nervous_system1.22469586
39MP0000762_abnormal_tongue_morphology1.21529579
40MP0003453_abnormal_keratinocyte_physiol1.19095303
41MP0008961_abnormal_basal_metabolism1.18376353
42MP0000733_abnormal_muscle_development1.16972210
43MP0001672_abnormal_embryogenesis/_devel1.15929088
44MP0005380_embryogenesis_phenotype1.15929088
45MP0000313_abnormal_cell_death1.14958145
46MP0002019_abnormal_tumor_incidence1.12123625
47MP0003091_abnormal_cell_migration1.11715621
48MP0000566_synostosis1.11366265
49MP0003984_embryonic_growth_retardation1.10925718
50MP0001697_abnormal_embryo_size1.10373567
51MP0002398_abnormal_bone_marrow1.08924005
52MP0010630_abnormal_cardiac_muscle1.08879761
53MP0009672_abnormal_birth_weight1.08113696
54MP0002234_abnormal_pharynx_morphology1.08025818
55MP0002269_muscular_atrophy1.06638513
56MP0005384_cellular_phenotype1.05769877
57MP0001849_ear_inflammation1.05685052
58MP0001873_stomach_inflammation1.04298852
59MP0002088_abnormal_embryonic_growth/wei1.03633620
60MP0000759_abnormal_skeletal_muscle1.02922706
61MP0004957_abnormal_blastocyst_morpholog1.02602510
62MP0003045_fibrosis1.01808726
63MP0004381_abnormal_hair_follicle1.01514506
64MP0004185_abnormal_adipocyte_glucose1.00914079
65MP0008932_abnormal_embryonic_tissue0.99858447
66MP0002080_prenatal_lethality0.98528463
67MP0000678_abnormal_parathyroid_gland0.96422854
68MP0003385_abnormal_body_wall0.96298711
69MP0005375_adipose_tissue_phenotype0.95925164
70MP0001348_abnormal_lacrimal_gland0.92171768
71MP0002166_altered_tumor_susceptibility0.91113053
72MP0002116_abnormal_craniofacial_bone0.88893509
73MP0002177_abnormal_outer_ear0.88721713
74MP0002970_abnormal_white_adipose0.88119262
75MP0002722_abnormal_immune_system0.87849649
76MP0005671_abnormal_response_to0.85709984
77MP0002086_abnormal_extraembryonic_tissu0.85410691
78MP0003699_abnormal_female_reproductive0.83108030
79MP0005501_abnormal_skin_physiology0.78974065
80MP0002085_abnormal_embryonic_tissue0.78436168
81MP0000432_abnormal_head_morphology0.78409652
82MP0003935_abnormal_craniofacial_develop0.77924566
83MP0000689_abnormal_spleen_morphology0.77851523
84MP0001915_intracranial_hemorrhage0.77171846
85MP0010368_abnormal_lymphatic_system0.75287728
86MP0000490_abnormal_crypts_of0.75064774
87MP0003436_decreased_susceptibility_to0.74968228
88MP0003943_abnormal_hepatobiliary_system0.73616389
89MP0003221_abnormal_cardiomyocyte_apopto0.73407766
90MP0002114_abnormal_axial_skeleton0.73378569
91MP0001216_abnormal_epidermal_layer0.72877676
92MP0003300_gastrointestinal_ulcer0.72241310
93MP0004264_abnormal_extraembryonic_tissu0.72094748
94MP0002084_abnormal_developmental_patter0.71600635
95MP0008770_decreased_survivor_rate0.71456433
96MP0002420_abnormal_adaptive_immunity0.71139959
97MP0001800_abnormal_humoral_immune0.70683382
98MP0003861_abnormal_nervous_system0.69263781
99MP0001819_abnormal_immune_cell0.69160040
100MP0002429_abnormal_blood_cell0.69048700

Predicted human phenotypes

RankGene SetZ-score
1Fatigue (HP:0012378)6.93915505
2Cerebellar dysplasia (HP:0007033)6.66333177
3Retinal atrophy (HP:0001105)6.50884953
4Difficulty climbing stairs (HP:0003551)5.38628089
5Hypoplasia of the pons (HP:0012110)5.26945717
6Type II lissencephaly (HP:0007260)4.95250998
7Abnormality of the fingertips (HP:0001211)4.86439453
8Abnormality of the pons (HP:0007361)4.69141842
9Buphthalmos (HP:0000557)4.58174675
10Retinal dysplasia (HP:0007973)4.52698010
11Aplasia/Hypoplasia affecting the retina (HP:0008061)4.52613949
12Megalocornea (HP:0000485)3.73691823
13Generalized hypotonia (HP:0001290)3.56301434
14Poikiloderma (HP:0001029)3.34775457
15Congenital glaucoma (HP:0001087)2.97735565
16Lip pit (HP:0100267)2.96749589
17Sparse lateral eyebrow (HP:0005338)2.95334868
18Obstructive sleep apnea (HP:0002870)2.93497990
19Entropion (HP:0000621)2.92895968
20Decreased electroretinogram (ERG) amplitude (HP:0000654)2.81780631
21Depressed nasal tip (HP:0000437)2.81027651
22Abnormality of DNA repair (HP:0003254)2.77045846
23Supranuclear gaze palsy (HP:0000605)2.69492375
24Urethral obstruction (HP:0000796)2.66065992
25Severe muscular hypotonia (HP:0006829)2.62748299
26Hyperacusis (HP:0010780)2.62694184
27Non-midline cleft lip (HP:0100335)2.37561313
28Long eyelashes (HP:0000527)2.35502707
29Intellectual disability, profound (HP:0002187)2.31171490
30Slow saccadic eye movements (HP:0000514)2.30015095
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27821348
32Ectopic kidney (HP:0000086)2.22181880
33High anterior hairline (HP:0009890)2.21158374
34Chromsome breakage (HP:0040012)2.20442072
35Anal stenosis (HP:0002025)2.19454812
36Abnormality of vision evoked potentials (HP:0000649)2.13103983
37Broad face (HP:0000283)2.10152838
38Prominent metopic ridge (HP:0005487)2.01115929
39Sacral dimple (HP:0000960)1.98678205
40Long palpebral fissure (HP:0000637)1.97781490
41Ectropion (HP:0000656)1.95516008
42Breast hypoplasia (HP:0003187)1.94165302
43Dysmetric saccades (HP:0000641)1.94147435
44Aplasia/Hypoplasia of the brainstem (HP:0007362)1.93647994
45Hypoplasia of the brainstem (HP:0002365)1.93647994
46Ankyloglossia (HP:0010296)1.93533338
47Abnormality of oral frenula (HP:0000190)1.89718772
48Severe global developmental delay (HP:0011344)1.87240879
49Rectal prolapse (HP:0002035)1.85685707
50Prominent nose (HP:0000448)1.83267210
51Generalized muscle weakness (HP:0003324)1.83160709
52Acute lymphatic leukemia (HP:0006721)1.80796785
53Disproportionate tall stature (HP:0001519)1.80638492
54Lissencephaly (HP:0001339)1.79790814
55Muscular dystrophy (HP:0003560)1.78541321
56Ureteral stenosis (HP:0000071)1.76465619
57Trigonocephaly (HP:0000243)1.74511191
58Supernumerary ribs (HP:0005815)1.73061850
59Muscle stiffness (HP:0003552)1.72329053
60Dislocated radial head (HP:0003083)1.70988799
61Abnormality of the radial head (HP:0003995)1.70706863
62Abnormality of the metopic suture (HP:0005556)1.70422176
63Narrow palate (HP:0000189)1.70102531
64Short 1st metacarpal (HP:0010034)1.69709493
65Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.69709493
66Overlapping toe (HP:0001845)1.68725882
67Preauricular skin tag (HP:0000384)1.67071328
68Trismus (HP:0000211)1.66619351
69Heterotopia (HP:0002282)1.65676009
70Severe visual impairment (HP:0001141)1.65617957
71Precocious puberty (HP:0000826)1.64421759
72Meningocele (HP:0002435)1.63518406
73Pointed chin (HP:0000307)1.63193207
74Selective tooth agenesis (HP:0001592)1.62931351
75IgA deficiency (HP:0002720)1.61699380
76Pachygyria (HP:0001302)1.61247995
77Abnormality of subcutaneous fat tissue (HP:0001001)1.60498839
78Ureteral obstruction (HP:0006000)1.60353483
79Abnormality of incisor morphology (HP:0011063)1.59205325
80Fragile nails (HP:0001808)1.59048815
81Intestinal fistula (HP:0100819)1.57527468
82Deep palmar crease (HP:0006191)1.57509889
83Papilledema (HP:0001085)1.57395284
84Increased IgM level (HP:0003496)1.57094942
85Asymmetry of the thorax (HP:0001555)1.56055001
86Abnormality of the distal phalanx of the thumb (HP:0009617)1.55512777
87Urinary glycosaminoglycan excretion (HP:0003541)1.54138483
88Mucopolysacchariduria (HP:0008155)1.54138483
89Skin tags (HP:0010609)1.53723148
90Centrally nucleated skeletal muscle fibers (HP:0003687)1.53642625
91IgG deficiency (HP:0004315)1.52933651
92Premature ovarian failure (HP:0008209)1.52253473
93Skull defect (HP:0001362)1.52082692
94Gowers sign (HP:0003391)1.51576187
95Decreased subcutaneous fat (HP:0001002)1.50535972
96Spina bifida occulta (HP:0003298)1.49282572
97High pitched voice (HP:0001620)1.48124233
98Cafe-au-lait spot (HP:0000957)1.47029463
99Sandal gap (HP:0001852)1.46817345
100Abnormality of the columella (HP:0009929)1.46609506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.14649892
2STK104.59621727
3MARK34.28667479
4TRIB33.99935419
5SMG13.01148170
6EEF2K2.95052813
7PRPF4B2.87934134
8ICK2.66803149
9BRD42.32159474
10MAP3K102.07711953
11SIK12.05747849
12MAP4K11.88736935
13ERN11.74652067
14CAMK1D1.67144323
15STK111.50760965
16CAMK1G1.48948674
17PIM11.48142182
18MTOR1.43214094
19SIK21.37742904
20FGFR41.36613986
21PRKD21.30037261
22TAOK11.29750182
23PKN21.27133398
24TTN1.23633928
25LMTK21.23545996
26MARK21.19429791
27MAP3K131.19375866
28TNK21.17102517
29MELK1.16408105
30CDC42BPA1.14102164
31CDK41.08864398
32NLK1.03615896
33MAP3K31.03126041
34CDC71.01539932
35ZAP701.01472793
36PTK2B1.00188016
37MAPK110.95849798
38RIPK10.95506690
39CCNB10.94897063
40STK240.93914257
41WNK10.91794952
42CDK70.89495702
43HIPK20.88335641
44IRAK30.87820934
45PRKCH0.86938367
46PRKD30.85893393
47EPHB10.85066137
48MAP2K30.83783263
49CHEK10.82704477
50CHEK20.75172867
51CDK90.74264791
52RPS6KC10.73045101
53RPS6KL10.73045101
54MAP2K20.71027441
55TTK0.67657215
56CAMKK10.67469674
57TAOK20.64064669
58RPS6KA20.63493455
59CAMK40.62556916
60MAP3K70.61653296
61RPS6KA60.59961237
62ATR0.59102600
63CDK20.58898314
64SIK30.58769903
65SGK30.57906307
66PASK0.57838486
67NEK60.57369816
68PTK20.54718744
69RPS6KB20.51356476
70BMX0.50909068
71MAP3K140.50679962
72CHUK0.49848931
73TXK0.48779598
74MAP3K80.48008084
75BRSK10.46427898
76IKBKE0.45584847
77PRKAA10.44872216
78MAPK70.41450541
79MAP3K110.41050419
80MAPK140.40809387
81CDK10.40449171
82MAPK10.39614806
83UHMK10.38740888
84KSR20.38315195
85STK380.37043026
86BLK0.36888867
87RPS6KA10.36491303
88YES10.35153833
89KDR0.34943939
90GSK3B0.34034112
91MAPK80.33166297
92TRPM70.32884975
93MAP3K10.32747482
94BUB10.32335852
95CAMK10.31982298
96CSF1R0.31400694
97ATM0.30764314
98FGFR30.30326078
99MAPK120.30280833
100HCK0.29581159

Predicted pathways (KEGG)

RankGene SetZ-score
1Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.74073898
2Acute myeloid leukemia_Homo sapiens_hsa052212.19261782
3Lysine degradation_Homo sapiens_hsa003102.11072666
4Chronic myeloid leukemia_Homo sapiens_hsa052202.08551514
5Non-small cell lung cancer_Homo sapiens_hsa052231.72762279
6B cell receptor signaling pathway_Homo sapiens_hsa046621.68019764
7Phosphatidylinositol signaling system_Homo sapiens_hsa040701.64688512
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.64114672
9DNA replication_Homo sapiens_hsa030301.62246413
10Pancreatic cancer_Homo sapiens_hsa052121.50146223
11Longevity regulating pathway - mammal_Homo sapiens_hsa042111.49630680
12mTOR signaling pathway_Homo sapiens_hsa041501.48317495
13Cell cycle_Homo sapiens_hsa041101.47131686
14Thyroid hormone signaling pathway_Homo sapiens_hsa049191.45769314
15Prostate cancer_Homo sapiens_hsa052151.45539469
16mRNA surveillance pathway_Homo sapiens_hsa030151.40667611
17Inositol phosphate metabolism_Homo sapiens_hsa005621.37610948
18T cell receptor signaling pathway_Homo sapiens_hsa046601.33357227
19TNF signaling pathway_Homo sapiens_hsa046681.32877994
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32053378
21Colorectal cancer_Homo sapiens_hsa052101.30485484
22AMPK signaling pathway_Homo sapiens_hsa041521.30059567
23Notch signaling pathway_Homo sapiens_hsa043301.29653652
24Hepatitis B_Homo sapiens_hsa051611.28712335
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25727663
26Base excision repair_Homo sapiens_hsa034101.25547510
27Endometrial cancer_Homo sapiens_hsa052131.25167038
28MicroRNAs in cancer_Homo sapiens_hsa052061.23806084
29Vitamin B6 metabolism_Homo sapiens_hsa007501.23731502
30Osteoclast differentiation_Homo sapiens_hsa043801.16408247
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.15195864
32Herpes simplex infection_Homo sapiens_hsa051681.14973124
33Glioma_Homo sapiens_hsa052141.14647963
34Small cell lung cancer_Homo sapiens_hsa052221.12527663
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12511745
36Non-homologous end-joining_Homo sapiens_hsa034501.12237651
37Insulin signaling pathway_Homo sapiens_hsa049101.11695090
38Primary immunodeficiency_Homo sapiens_hsa053401.08367997
39Renal cell carcinoma_Homo sapiens_hsa052111.08345592
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04362796
41ErbB signaling pathway_Homo sapiens_hsa040121.03246463
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02918097
43Viral carcinogenesis_Homo sapiens_hsa052031.02409447
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.01493211
45Toxoplasmosis_Homo sapiens_hsa051451.01449726
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01274310
47VEGF signaling pathway_Homo sapiens_hsa043700.99592391
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98468929
49Epstein-Barr virus infection_Homo sapiens_hsa051690.98231474
50Estrogen signaling pathway_Homo sapiens_hsa049150.97194463
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95979378
52Glucagon signaling pathway_Homo sapiens_hsa049220.94965100
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94576444
54MAPK signaling pathway_Homo sapiens_hsa040100.93273474
55Apoptosis_Homo sapiens_hsa042100.92761660
56Bladder cancer_Homo sapiens_hsa052190.92733996
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.92163450
58Hepatitis C_Homo sapiens_hsa051600.91478936
59Thyroid cancer_Homo sapiens_hsa052160.91381933
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89490520
61HTLV-I infection_Homo sapiens_hsa051660.87807513
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87733057
63Insulin resistance_Homo sapiens_hsa049310.86150044
64Fanconi anemia pathway_Homo sapiens_hsa034600.83367049
65Choline metabolism in cancer_Homo sapiens_hsa052310.83140155
66RNA transport_Homo sapiens_hsa030130.78980564
67Measles_Homo sapiens_hsa051620.78260126
68FoxO signaling pathway_Homo sapiens_hsa040680.76479037
69RNA polymerase_Homo sapiens_hsa030200.75959117
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.74681439
71GnRH signaling pathway_Homo sapiens_hsa049120.73371267
72Long-term potentiation_Homo sapiens_hsa047200.72248716
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71952023
74Adherens junction_Homo sapiens_hsa045200.71121415
75Leishmaniasis_Homo sapiens_hsa051400.69980252
76Spliceosome_Homo sapiens_hsa030400.69480959
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64850051
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64421986
79Influenza A_Homo sapiens_hsa051640.63742851
80p53 signaling pathway_Homo sapiens_hsa041150.62382661
81Shigellosis_Homo sapiens_hsa051310.61479826
82Prolactin signaling pathway_Homo sapiens_hsa049170.61222324
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60036915
84One carbon pool by folate_Homo sapiens_hsa006700.58954672
85Proteoglycans in cancer_Homo sapiens_hsa052050.58192134
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.57505334
87Rap1 signaling pathway_Homo sapiens_hsa040150.56503386
88Endocytosis_Homo sapiens_hsa041440.53722960
89Chemokine signaling pathway_Homo sapiens_hsa040620.52726900
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52336530
91Melanogenesis_Homo sapiens_hsa049160.52133704
92Focal adhesion_Homo sapiens_hsa045100.52113898
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51738055
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51550297
95Cholinergic synapse_Homo sapiens_hsa047250.51360862
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49069378
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48927646
98Pathways in cancer_Homo sapiens_hsa052000.47151957
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.46757967
100Type II diabetes mellitus_Homo sapiens_hsa049300.45068600

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