ZNF143

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)6.30424129
2cell wall macromolecule metabolic process (GO:0044036)5.07386798
3synapsis (GO:0007129)4.90725566
4DNA double-strand break processing (GO:0000729)4.63819843
5piRNA metabolic process (GO:0034587)4.33431811
6CENP-A containing nucleosome assembly (GO:0034080)4.28964010
7chromatin remodeling at centromere (GO:0031055)4.19412373
8myelin assembly (GO:0032288)4.12255819
9histone exchange (GO:0043486)4.08521427
10male meiosis I (GO:0007141)4.07149958
11proteasome assembly (GO:0043248)3.99115614
12nuclear pore complex assembly (GO:0051292)3.99015044
13regulation of meiosis I (GO:0060631)3.84872926
14resolution of meiotic recombination intermediates (GO:0000712)3.84113202
15negative regulation of DNA-dependent DNA replication (GO:2000104)3.82608123
16attachment of spindle microtubules to kinetochore (GO:0008608)3.81332365
17nuclear pore organization (GO:0006999)3.80020976
18RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.77997405
19sister chromatid cohesion (GO:0007062)3.75494031
20regulation of DNA endoreduplication (GO:0032875)3.68347066
21rRNA modification (GO:0000154)3.64695217
22DNA replication-dependent nucleosome assembly (GO:0006335)3.62761067
23DNA replication-dependent nucleosome organization (GO:0034723)3.62761067
24meiosis I (GO:0007127)3.58836472
25mitotic sister chromatid cohesion (GO:0007064)3.57702065
26male meiosis (GO:0007140)3.54834603
27rRNA methylation (GO:0031167)3.53404232
28DNA replication checkpoint (GO:0000076)3.47927575
29DNA replication-independent nucleosome assembly (GO:0006336)3.46941623
30DNA replication-independent nucleosome organization (GO:0034724)3.46941623
31meiotic nuclear division (GO:0007126)3.46567340
32DNA methylation involved in gamete generation (GO:0043046)3.42652034
33regulation of MHC class II biosynthetic process (GO:0045346)3.41402719
34ribosome assembly (GO:0042255)3.40693317
35protein localization to kinetochore (GO:0034501)3.37696656
36histone H2A acetylation (GO:0043968)3.37601945
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.32835332
38mitotic metaphase plate congression (GO:0007080)3.32745723
39centriole replication (GO:0007099)3.32440830
40histone mRNA metabolic process (GO:0008334)3.31507389
41negative regulation of meiosis (GO:0045835)3.30217093
42metaphase plate congression (GO:0051310)3.29316782
43DNA catabolic process, exonucleolytic (GO:0000738)3.29042826
44microtubule anchoring (GO:0034453)3.27363923
45N-terminal protein amino acid acetylation (GO:0006474)3.26950990
46mitotic recombination (GO:0006312)3.21768104
47chromosome organization involved in meiosis (GO:0070192)3.21469501
48negative regulation of DNA recombination (GO:0045910)3.21282747
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.20220376
50regulation of mitotic spindle checkpoint (GO:1903504)3.20220376
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14453092
52monoubiquitinated protein deubiquitination (GO:0035520)3.14439146
53telomere maintenance via semi-conservative replication (GO:0032201)3.10572539
54recombinational repair (GO:0000725)3.09053259
55spindle checkpoint (GO:0031577)3.08888663
56meiotic cell cycle process (GO:1903046)3.08779696
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05106652
58non-recombinational repair (GO:0000726)3.04434249
59double-strand break repair via nonhomologous end joining (GO:0006303)3.04434249
60DNA synthesis involved in DNA repair (GO:0000731)3.03853591
61double-strand break repair via homologous recombination (GO:0000724)3.03143986
62regulation of centriole replication (GO:0046599)3.01777619
63telomere maintenance via recombination (GO:0000722)3.01761260
64cullin deneddylation (GO:0010388)3.00196531
65histone mRNA catabolic process (GO:0071044)2.99838060
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99365523
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98990761
68replication fork processing (GO:0031297)2.98550400
69pore complex assembly (GO:0046931)2.96936840
70negative regulation of mitotic sister chromatid separation (GO:2000816)2.94918387
71negative regulation of sister chromatid segregation (GO:0033046)2.94918387
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94918387
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94918387
74negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94918387
75DNA strand elongation involved in DNA replication (GO:0006271)2.94577545
76mitotic spindle checkpoint (GO:0071174)2.93781049
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89228299
78regulation of double-strand break repair via homologous recombination (GO:0010569)2.88625623
79negative regulation of chromosome segregation (GO:0051985)2.88465221
80regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87664530
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87664530
82regulation of sister chromatid segregation (GO:0033045)2.87469570
83regulation of mitotic sister chromatid separation (GO:0010965)2.87469570
84regulation of mitotic sister chromatid segregation (GO:0033047)2.87469570
85reciprocal meiotic recombination (GO:0007131)2.87213051
86reciprocal DNA recombination (GO:0035825)2.87213051
87DNA-dependent DNA replication (GO:0006261)2.86218463
88establishment of chromosome localization (GO:0051303)2.83483443
89meiotic cell cycle (GO:0051321)2.82213093
90positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.79513127
91positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.79513127
92positive regulation of mitotic sister chromatid separation (GO:1901970)2.79513127
93regulation of chromosome segregation (GO:0051983)2.78501940
94mitotic nuclear envelope disassembly (GO:0007077)2.76702380
95mitochondrial DNA replication (GO:0006264)2.76215718
96DNA strand elongation (GO:0022616)2.76098218
97mitotic G2/M transition checkpoint (GO:0044818)2.75864598
98gene silencing by RNA (GO:0031047)2.75358055
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.74427407
100positive regulation of macrophage activation (GO:0043032)2.72985335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.74727784
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.69684783
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.66952689
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65918021
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.40342934
6ELK1_19687146_ChIP-ChIP_HELA_Human3.16483395
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.94282624
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65824353
9* VDR_23849224_ChIP-Seq_CD4+_Human2.54636724
10PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.52481684
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49404547
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42787211
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35403044
14ZNF274_21170338_ChIP-Seq_K562_Hela2.34162389
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23464414
16* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15210473
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15063415
18PADI4_21655091_ChIP-ChIP_MCF-7_Human2.12265774
19FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.08839583
20* ETS1_20019798_ChIP-Seq_JURKAT_Human2.08520990
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03935110
22FOXP3_21729870_ChIP-Seq_TREG_Human2.03752496
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00021243
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.99344018
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.88792461
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88510158
27EWS_26573619_Chip-Seq_HEK293_Human1.87483913
28HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87177172
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84661775
30VDR_22108803_ChIP-Seq_LS180_Human1.82692702
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.74641951
32FUS_26573619_Chip-Seq_HEK293_Human1.73046975
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62180731
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60063596
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54899797
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54782173
37TAF15_26573619_Chip-Seq_HEK293_Human1.52347503
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51781278
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49902731
40GBX2_23144817_ChIP-Seq_PC3_Human1.49060721
41AR_21909140_ChIP-Seq_LNCAP_Human1.48881659
42DCP1A_22483619_ChIP-Seq_HELA_Human1.46307940
43MYC_18940864_ChIP-ChIP_HL60_Human1.44637749
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.38013338
45IRF1_19129219_ChIP-ChIP_H3396_Human1.33684456
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.32819536
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31584936
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.31548373
49* GABP_19822575_ChIP-Seq_HepG2_Human1.29974228
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28793338
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26994376
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26427104
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.23126031
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22958447
55CBP_20019798_ChIP-Seq_JUKART_Human1.20627018
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20627018
57SALL4_22934838_ChIP-ChIP_CD34+_Human1.19530551
58P300_19829295_ChIP-Seq_ESCs_Human1.18824001
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14262989
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12774744
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08725856
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08280401
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07871242
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07827077
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07146112
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06535406
67* TP53_22573176_ChIP-Seq_HFKS_Human1.05205825
68TFEB_21752829_ChIP-Seq_HELA_Human1.03353133
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.03051689
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02798127
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01553188
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01209728
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00310167
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.00079255
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99757431
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98714295
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98693785
78THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98594788
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98563637
80* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96785896
81CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95654530
82* TTF2_22483619_ChIP-Seq_HELA_Human0.95491200
83* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95400696
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93828772
85MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92314796
86GATA3_26560356_Chip-Seq_TH2_Human0.91380487
87ER_23166858_ChIP-Seq_MCF-7_Human0.90421445
88OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89854418
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89833039
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89399548
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89390115
92MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89329333
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87882097
94* CDX2_22108803_ChIP-Seq_LS180_Human0.87614951
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87177316
96CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84328870
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83517463
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82791875
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82625388
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82433233

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.15511286
2MP0008058_abnormal_DNA_repair4.28471669
3MP0010094_abnormal_chromosome_stability4.01051790
4MP0008057_abnormal_DNA_replication3.64725567
5MP0008260_abnormal_autophagy3.48499501
6MP0003693_abnormal_embryo_hatching3.07742496
7MP0003890_abnormal_embryonic-extraembry3.05082656
8MP0003077_abnormal_cell_cycle2.88477466
9MP0003718_maternal_effect2.82607335
10MP0008789_abnormal_olfactory_epithelium2.67710597
11MP0003111_abnormal_nucleus_morphology2.63080235
12MP0004957_abnormal_blastocyst_morpholog2.46181145
13MP0003786_premature_aging2.26385870
14MP0006292_abnormal_olfactory_placode2.02846570
15MP0005499_abnormal_olfactory_system1.98897254
16MP0005394_taste/olfaction_phenotype1.98897254
17MP0002102_abnormal_ear_morphology1.96873890
18MP0003806_abnormal_nucleotide_metabolis1.92500497
19MP0006035_abnormal_mitochondrial_morpho1.88309185
20MP0008932_abnormal_embryonic_tissue1.88117963
21MP0002210_abnormal_sex_determination1.86305454
22MP0000372_irregular_coat_pigmentation1.85865248
23MP0003656_abnormal_erythrocyte_physiolo1.84942451
24MP0003567_abnormal_fetal_cardiomyocyte1.84548986
25MP0000569_abnormal_digit_pigmentation1.81920886
26MP0001929_abnormal_gametogenesis1.81243316
27MP0000015_abnormal_ear_pigmentation1.71514785
28MP0001188_hyperpigmentation1.66166052
29MP0003121_genomic_imprinting1.63913276
30MP0008007_abnormal_cellular_replicative1.63122665
31MP0003221_abnormal_cardiomyocyte_apopto1.62627527
32MP0010234_abnormal_vibrissa_follicle1.62386668
33MP0001293_anophthalmia1.62085625
34MP0010307_abnormal_tumor_latency1.51051089
35MP0003787_abnormal_imprinting1.50832514
36MP0009697_abnormal_copulation1.50174161
37MP0001984_abnormal_olfaction1.49026773
38MP0000653_abnormal_sex_gland1.41692752
39MP0002095_abnormal_skin_pigmentation1.41330607
40MP0001145_abnormal_male_reproductive1.37347306
41MP0002938_white_spotting1.34235507
42MP0004147_increased_porphyrin_level1.29761161
43MP0001986_abnormal_taste_sensitivity1.26636349
44MP0000358_abnormal_cell_content/1.18932289
45MP0001119_abnormal_female_reproductive1.17036160
46MP0010030_abnormal_orbit_morphology1.16744029
47MP0003698_abnormal_male_reproductive1.16664333
48MP0005174_abnormal_tail_pigmentation1.15651333
49MP0002233_abnormal_nose_morphology1.13593070
50MP0002396_abnormal_hematopoietic_system1.13586685
51MP0005075_abnormal_melanosome_morpholog1.12808696
52MP0001672_abnormal_embryogenesis/_devel1.08326369
53MP0005380_embryogenesis_phenotype1.08326369
54MP0006072_abnormal_retinal_apoptosis1.08022450
55MP0001730_embryonic_growth_arrest1.06841308
56MP0003880_abnormal_central_pattern1.02228552
57MP0001697_abnormal_embryo_size1.02202101
58MP0005395_other_phenotype1.02061801
59MP0000350_abnormal_cell_proliferation1.00678517
60MP0000647_abnormal_sebaceous_gland0.99713878
61MP0003724_increased_susceptibility_to0.98832793
62MP0010352_gastrointestinal_tract_polyps0.96738395
63MP0004215_abnormal_myocardial_fiber0.96170734
64MP0006054_spinal_hemorrhage0.95622643
65MP0000703_abnormal_thymus_morphology0.95510496
66MP0000490_abnormal_crypts_of0.94919179
67MP0002160_abnormal_reproductive_system0.91858429
68MP0001324_abnormal_eye_pigmentation0.91614006
69MP0000313_abnormal_cell_death0.88174277
70MP0005389_reproductive_system_phenotype0.86976290
71MP0005253_abnormal_eye_physiology0.86924829
72MP0004197_abnormal_fetal_growth/weight/0.85242689
73MP0002088_abnormal_embryonic_growth/wei0.84951409
74MP0005410_abnormal_fertilization0.84777832
75MP0005551_abnormal_eye_electrophysiolog0.82249503
76MP0003984_embryonic_growth_retardation0.81789100
77MP0002084_abnormal_developmental_patter0.80194441
78MP0003195_calcinosis0.79988065
79MP0000631_abnormal_neuroendocrine_gland0.79486648
80MP0001919_abnormal_reproductive_system0.77952332
81MP0005367_renal/urinary_system_phenotyp0.77558219
82MP0000516_abnormal_urinary_system0.77558219
83MP0002080_prenatal_lethality0.75289824
84MP0002161_abnormal_fertility/fecundity0.75128395
85MP0003937_abnormal_limbs/digits/tail_de0.74685219
86MP0001727_abnormal_embryo_implantation0.73753967
87MP0003699_abnormal_female_reproductive0.72943800
88MP0000689_abnormal_spleen_morphology0.72324378
89MP0008995_early_reproductive_senescence0.71238099
90MP0005384_cellular_phenotype0.70883345
91MP0002019_abnormal_tumor_incidence0.70878208
92MP0009785_altered_susceptibility_to0.70110990
93MP0002085_abnormal_embryonic_tissue0.67750333
94MP0010678_abnormal_skin_adnexa0.67584376
95MP0002751_abnormal_autonomic_nervous0.67426362
96MP0009703_decreased_birth_body0.66340484
97MP0004134_abnormal_chest_morphology0.66295229
98MP0009764_decreased_sensitivity_to0.65331612
99MP0002277_abnormal_respiratory_mucosa0.62666851
100MP0001835_abnormal_antigen_presentation0.62617524

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.03895795
2Volvulus (HP:0002580)3.94227911
3Chromsome breakage (HP:0040012)3.91748869
4Abnormality of chromosome stability (HP:0003220)3.84610064
5Meckel diverticulum (HP:0002245)3.82760529
6Abnormality of the ileum (HP:0001549)3.73781196
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.66577592
8Abnormality of the preputium (HP:0100587)3.26969440
9Abnormality of the labia minora (HP:0012880)3.20603101
10Type II lissencephaly (HP:0007260)3.13714449
11Retinal dysplasia (HP:0007973)3.10767042
12Papillary thyroid carcinoma (HP:0002895)2.98133743
13Colon cancer (HP:0003003)2.97772672
14Duodenal stenosis (HP:0100867)2.94931328
15Small intestinal stenosis (HP:0012848)2.94931328
16Molar tooth sign on MRI (HP:0002419)2.89293912
17Abnormality of midbrain morphology (HP:0002418)2.89293912
18Abnormality of DNA repair (HP:0003254)2.81173107
19Pancreatic cysts (HP:0001737)2.78969021
20Abnormality of the duodenum (HP:0002246)2.65761403
21Fair hair (HP:0002286)2.57809550
22Exercise-induced muscle cramps (HP:0003710)2.57382935
23Abnormal lung lobation (HP:0002101)2.56718325
24Abnormal biliary tract physiology (HP:0012439)2.49852390
25Bile duct proliferation (HP:0001408)2.49852390
26Intestinal atresia (HP:0011100)2.43334204
27Clubbing of toes (HP:0100760)2.41757806
28Median cleft lip (HP:0000161)2.37017841
29Abnormality of the carotid arteries (HP:0005344)2.36529331
30Nephroblastoma (Wilms tumor) (HP:0002667)2.35326970
31Cerebellar dysplasia (HP:0007033)2.34727791
32Myelodysplasia (HP:0002863)2.34608401
33Sloping forehead (HP:0000340)2.33818512
34Bifid tongue (HP:0010297)2.30723211
35Embryonal renal neoplasm (HP:0011794)2.21611418
36Oligodactyly (hands) (HP:0001180)2.18500862
37Neoplasm of the adrenal cortex (HP:0100641)2.16347025
38Medulloblastoma (HP:0002885)2.13410879
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.09853143
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09853143
41Medial flaring of the eyebrow (HP:0010747)2.09286005
42Short tibia (HP:0005736)2.06212647
43Squamous cell carcinoma (HP:0002860)2.05747634
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.05151655
45Congenital primary aphakia (HP:0007707)2.05121228
46Overlapping toe (HP:0001845)2.02797087
47Acute necrotizing encephalopathy (HP:0006965)2.01238574
48Pancreatic fibrosis (HP:0100732)1.99823085
49Horseshoe kidney (HP:0000085)1.99081382
50Astigmatism (HP:0000483)1.98258765
51Ectopic kidney (HP:0000086)1.94797741
52Lissencephaly (HP:0001339)1.94783509
53Rhabdomyosarcoma (HP:0002859)1.94464988
54Type I transferrin isoform profile (HP:0003642)1.92031943
55Abnormal spermatogenesis (HP:0008669)1.91526348
56Stomach cancer (HP:0012126)1.91499495
57Acute encephalopathy (HP:0006846)1.91029786
58Microvesicular hepatic steatosis (HP:0001414)1.90030017
59Thyroid carcinoma (HP:0002890)1.88311231
60Azoospermia (HP:0000027)1.86918035
61Stenosis of the external auditory canal (HP:0000402)1.86485972
62Poor coordination (HP:0002370)1.86408558
63Neoplasm of the adrenal gland (HP:0100631)1.85124338
64Increased nuchal translucency (HP:0010880)1.84796595
65Increased hepatocellular lipid droplets (HP:0006565)1.83764386
66Dyschromatopsia (HP:0007641)1.83748732
67Small hand (HP:0200055)1.83738417
68Nephrogenic diabetes insipidus (HP:0009806)1.83279918
69Abnormality of the anterior horn cell (HP:0006802)1.83106636
70Degeneration of anterior horn cells (HP:0002398)1.83106636
71Nephronophthisis (HP:0000090)1.82029006
72Gait imbalance (HP:0002141)1.81748235
73Abnormality of alanine metabolism (HP:0010916)1.80778387
74Hyperalaninemia (HP:0003348)1.80778387
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80778387
76Genital tract atresia (HP:0001827)1.79292025
77Septo-optic dysplasia (HP:0100842)1.79202837
78Optic nerve hypoplasia (HP:0000609)1.76283989
79Gastrointestinal atresia (HP:0002589)1.75801327
80Bone marrow hypocellularity (HP:0005528)1.75360337
81Aganglionic megacolon (HP:0002251)1.74526377
82Autoamputation (HP:0001218)1.74094385
83Abnormality of the septum pellucidum (HP:0007375)1.73340423
84Absent thumb (HP:0009777)1.72869357
85Atrophy/Degeneration involving motor neurons (HP:0007373)1.71530112
86Lipid accumulation in hepatocytes (HP:0006561)1.71273126
87Progressive macrocephaly (HP:0004481)1.71145139
88Amyotrophic lateral sclerosis (HP:0007354)1.69326711
89Absent septum pellucidum (HP:0001331)1.69132564
90Vaginal atresia (HP:0000148)1.69023858
91Dandy-Walker malformation (HP:0001305)1.68535907
92Tubular atrophy (HP:0000092)1.68520925
93Abnormality of macular pigmentation (HP:0008002)1.66638847
94Stomatitis (HP:0010280)1.66253253
95Hypoplastic labia majora (HP:0000059)1.66043544
96Triphalangeal thumb (HP:0001199)1.65797774
97Aplasia/Hypoplasia of the earlobes (HP:0009906)1.65520749
98Chronic hepatic failure (HP:0100626)1.65248102
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65104435
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.64301909

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.81714522
2BRSK23.43954438
3WEE12.92925408
4BUB12.72593584
5SRPK12.71660027
6TRIM282.70270483
7TSSK62.55715273
8MST42.41218333
9WNK32.29803810
10NUAK12.25096782
11BMPR1B2.22674090
12STK162.18573608
13ZAK2.02262602
14PLK41.96658228
15TTK1.93416649
16PLK31.92917012
17EIF2AK11.89083189
18PBK1.88817987
19CDC71.77537899
20MKNK21.64836162
21ACVR1B1.61705209
22EPHA41.59303381
23CDK191.53828193
24MAP3K41.49641723
25PLK21.47020436
26BRSK11.46204047
27PLK11.43336459
28MAP3K91.42569956
29PDK21.36466381
30MAP3K131.31444159
31FRK1.24524846
32TAOK31.24260462
33STK38L1.22769294
34MKNK11.19414840
35ATR1.18852320
36BCR1.15197404
37EIF2AK21.12397507
38ARAF1.11680645
39NEK11.04272349
40VRK10.98709116
41BCKDK0.98445750
42CDK30.96337081
43ERBB30.95225450
44CSNK1G30.94293426
45CSNK1G10.94006786
46CAMKK20.92016195
47MAP2K70.88221278
48BRD40.86891885
49CSNK1G20.86656238
50ATM0.85579649
51OXSR10.85472985
52BRAF0.83965022
53TEC0.83705724
54PNCK0.83082109
55TNIK0.82985406
56RAF10.81977816
57STK30.81152937
58DYRK20.71968622
59CSNK1A1L0.70448321
60NEK60.69834270
61FGR0.69523510
62CHEK10.65832571
63MAP3K50.64837652
64DYRK30.64046714
65PRKCE0.62116279
66AURKB0.61867148
67PAK30.61243981
68ERBB40.60354870
69CCNB10.59320158
70NLK0.58144404
71CASK0.53790512
72FER0.52137605
73TXK0.51299408
74MAP4K20.51097364
75MAPK130.50236603
76CDK70.48717986
77KIT0.48316380
78MAP3K140.47212833
79STK40.46585849
80PIM10.44599871
81STK100.43668987
82RPS6KA40.43603497
83MELK0.42028793
84KSR10.41526218
85YES10.41021132
86TGFBR10.40675148
87RPS6KA50.39492973
88TNK20.37578299
89CHEK20.36784875
90MET0.35653271
91INSRR0.33060469
92MOS0.32910380
93CSNK2A10.31242472
94CDK10.31093463
95ADRBK20.29685306
96CSK0.29566509
97EGFR0.27643003
98LIMK10.27399910
99PRKACB0.26869892
100CDK20.26466451

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.74095712
2Homologous recombination_Homo sapiens_hsa034403.68308402
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56381632
4Mismatch repair_Homo sapiens_hsa034303.52648621
5Basal transcription factors_Homo sapiens_hsa030223.15774357
6DNA replication_Homo sapiens_hsa030302.98633172
7Non-homologous end-joining_Homo sapiens_hsa034502.90830385
8Fanconi anemia pathway_Homo sapiens_hsa034602.81586144
9Protein export_Homo sapiens_hsa030602.55198058
10RNA degradation_Homo sapiens_hsa030182.53138565
11RNA transport_Homo sapiens_hsa030132.47553737
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36716256
13Nucleotide excision repair_Homo sapiens_hsa034202.29843060
14Regulation of autophagy_Homo sapiens_hsa041402.28741112
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.20740798
16Cell cycle_Homo sapiens_hsa041102.17445097
17RNA polymerase_Homo sapiens_hsa030202.07277622
18Selenocompound metabolism_Homo sapiens_hsa004502.05631549
19Spliceosome_Homo sapiens_hsa030401.84557075
20Base excision repair_Homo sapiens_hsa034101.82149193
21mRNA surveillance pathway_Homo sapiens_hsa030151.74674319
22Steroid biosynthesis_Homo sapiens_hsa001001.74040027
23Propanoate metabolism_Homo sapiens_hsa006401.60112803
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59886815
25p53 signaling pathway_Homo sapiens_hsa041151.58532991
26Oxidative phosphorylation_Homo sapiens_hsa001901.53124044
27Parkinsons disease_Homo sapiens_hsa050121.52556825
28Huntingtons disease_Homo sapiens_hsa050161.29910866
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24579685
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22416568
31Oocyte meiosis_Homo sapiens_hsa041141.12589828
32Nitrogen metabolism_Homo sapiens_hsa009101.08874723
33Legionellosis_Homo sapiens_hsa051341.08612367
34Antigen processing and presentation_Homo sapiens_hsa046121.02143130
35Pyrimidine metabolism_Homo sapiens_hsa002401.02080834
36Sulfur metabolism_Homo sapiens_hsa009200.99511482
37Allograft rejection_Homo sapiens_hsa053300.99224578
38Asthma_Homo sapiens_hsa053100.98007603
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97208676
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97008775
41Autoimmune thyroid disease_Homo sapiens_hsa053200.96305501
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.94805378
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94509706
44Purine metabolism_Homo sapiens_hsa002300.91167789
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89692834
46Type I diabetes mellitus_Homo sapiens_hsa049400.88348358
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85968878
48Graft-versus-host disease_Homo sapiens_hsa053320.84436144
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84366169
50Epstein-Barr virus infection_Homo sapiens_hsa051690.83959169
51Circadian rhythm_Homo sapiens_hsa047100.78132126
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77666458
53Shigellosis_Homo sapiens_hsa051310.75113252
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71587711
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68005794
56Herpes simplex infection_Homo sapiens_hsa051680.64438038
57Phagosome_Homo sapiens_hsa041450.63191448
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62974304
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58089540
60Viral myocarditis_Homo sapiens_hsa054160.55211861
61Alzheimers disease_Homo sapiens_hsa050100.54299975
62Peroxisome_Homo sapiens_hsa041460.52346479
63Rheumatoid arthritis_Homo sapiens_hsa053230.49291702
64Measles_Homo sapiens_hsa051620.48340463
65Systemic lupus erythematosus_Homo sapiens_hsa053220.47101206
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44761765
67Collecting duct acid secretion_Homo sapiens_hsa049660.42687123
68FoxO signaling pathway_Homo sapiens_hsa040680.40307862
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39902469
70Viral carcinogenesis_Homo sapiens_hsa052030.38459530
71One carbon pool by folate_Homo sapiens_hsa006700.37505623
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.37384373
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37029540
74Fatty acid elongation_Homo sapiens_hsa000620.35639423
75Caffeine metabolism_Homo sapiens_hsa002320.34730103
76Phototransduction_Homo sapiens_hsa047440.34726987
77Tryptophan metabolism_Homo sapiens_hsa003800.33881249
78Pyruvate metabolism_Homo sapiens_hsa006200.32298271
79Glutathione metabolism_Homo sapiens_hsa004800.29707301
80Influenza A_Homo sapiens_hsa051640.28667840
81Dorso-ventral axis formation_Homo sapiens_hsa043200.26859803
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24771856
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23473754
84Metabolic pathways_Homo sapiens_hsa011000.23283260
85Primary immunodeficiency_Homo sapiens_hsa053400.22415905
86Tuberculosis_Homo sapiens_hsa051520.21819037
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19685466
88Adherens junction_Homo sapiens_hsa045200.19142843
89Taste transduction_Homo sapiens_hsa047420.16669133
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.16571982
91Apoptosis_Homo sapiens_hsa042100.15873572
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15837502
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15718519
94Alcoholism_Homo sapiens_hsa050340.15543692
95beta-Alanine metabolism_Homo sapiens_hsa004100.14886042
96Fatty acid metabolism_Homo sapiens_hsa012120.14605123
97Long-term depression_Homo sapiens_hsa047300.14351264
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14254711
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.13697046
100TGF-beta signaling pathway_Homo sapiens_hsa043500.13427584

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