ZNF146

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.77517077
2nuclear pore organization (GO:0006999)5.34425877
3DNA double-strand break processing (GO:0000729)4.89659431
4establishment of integrated proviral latency (GO:0075713)4.86665379
5protein localization to kinetochore (GO:0034501)4.55674318
6DNA replication checkpoint (GO:0000076)4.40878984
7DNA unwinding involved in DNA replication (GO:0006268)4.37556729
8DNA strand elongation involved in DNA replication (GO:0006271)4.28458501
9sister chromatid segregation (GO:0000819)4.27401282
10mitotic sister chromatid cohesion (GO:0007064)4.22599092
11pore complex assembly (GO:0046931)4.22288008
12mitotic sister chromatid segregation (GO:0000070)4.20023355
13ribosome assembly (GO:0042255)4.18787429
14mitotic metaphase plate congression (GO:0007080)4.17937954
15chromatin remodeling at centromere (GO:0031055)4.17463915
16CENP-A containing nucleosome assembly (GO:0034080)4.13178494
17protein localization to chromosome, centromeric region (GO:0071459)4.11557105
18DNA strand elongation (GO:0022616)4.09687780
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.06578154
20DNA ligation (GO:0006266)3.99531902
21telomere maintenance via semi-conservative replication (GO:0032201)3.98400226
22mitotic nuclear envelope disassembly (GO:0007077)3.94792648
23double-strand break repair via nonhomologous end joining (GO:0006303)3.90085276
24non-recombinational repair (GO:0000726)3.90085276
25regulation of centriole replication (GO:0046599)3.88333722
26DNA topological change (GO:0006265)3.85972023
27metaphase plate congression (GO:0051310)3.75884779
28mitotic chromosome condensation (GO:0007076)3.74714282
29nuclear envelope disassembly (GO:0051081)3.69236045
30membrane disassembly (GO:0030397)3.69236045
31regulation of DNA endoreduplication (GO:0032875)3.62355854
32spindle checkpoint (GO:0031577)3.61843875
33IMP biosynthetic process (GO:0006188)3.60129351
34mitotic recombination (GO:0006312)3.56643123
35positive regulation of chromosome segregation (GO:0051984)3.55899222
36DNA replication-independent nucleosome assembly (GO:0006336)3.55067864
37DNA replication-independent nucleosome organization (GO:0034724)3.55067864
38establishment of viral latency (GO:0019043)3.53577532
39negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.53049113
40telomere maintenance via recombination (GO:0000722)3.52955126
41histone exchange (GO:0043486)3.52680583
42mitotic spindle checkpoint (GO:0071174)3.49514864
43DNA replication-dependent nucleosome assembly (GO:0006335)3.48315652
44DNA replication-dependent nucleosome organization (GO:0034723)3.48315652
45formation of translation preinitiation complex (GO:0001731)3.46051241
46regulation of chromosome segregation (GO:0051983)3.45321784
47negative regulation of chromosome segregation (GO:0051985)3.45135804
48pre-miRNA processing (GO:0031054)3.44911367
49negative regulation of mitotic sister chromatid separation (GO:2000816)3.42403443
50negative regulation of sister chromatid segregation (GO:0033046)3.42403443
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.42403443
52negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.42403443
53negative regulation of mitotic sister chromatid segregation (GO:0033048)3.42403443
54regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.42246230
55regulation of mitotic metaphase/anaphase transition (GO:0030071)3.42246230
56purine nucleobase biosynthetic process (GO:0009113)3.39882785
57kinetochore organization (GO:0051383)3.37003079
58negative regulation of mRNA processing (GO:0050686)3.36482553
59establishment of chromosome localization (GO:0051303)3.36388822
60IMP metabolic process (GO:0046040)3.35784264
61regulation of mitotic sister chromatid separation (GO:0010965)3.35098499
62regulation of mitotic sister chromatid segregation (GO:0033047)3.35098499
63regulation of sister chromatid segregation (GO:0033045)3.35098499
64DNA replication initiation (GO:0006270)3.34738589
65DNA duplex unwinding (GO:0032508)3.34621242
66DNA geometric change (GO:0032392)3.29445796
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.28907771
68positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.28907771
69positive regulation of mitotic sister chromatid separation (GO:1901970)3.28907771
70regulation of mitotic spindle organization (GO:0060236)3.25792209
71somatic hypermutation of immunoglobulin genes (GO:0016446)3.24437164
72somatic diversification of immune receptors via somatic mutation (GO:0002566)3.24437164
73mitotic spindle assembly checkpoint (GO:0007094)3.24379057
74ATP-dependent chromatin remodeling (GO:0043044)3.23395229
75spindle assembly checkpoint (GO:0071173)3.21503966
76regulation of centrosome cycle (GO:0046605)3.21449494
77nucleobase biosynthetic process (GO:0046112)3.18050148
78regulation of spindle organization (GO:0090224)3.17179338
79tRNA aminoacylation for protein translation (GO:0006418)3.13835670
80regulation of sister chromatid cohesion (GO:0007063)3.12667619
81mitochondrial DNA replication (GO:0006264)3.11638837
82DNA catabolic process, exonucleolytic (GO:0000738)3.11398650
83heterochromatin organization (GO:0070828)3.10638240
84negative regulation of mRNA metabolic process (GO:1903312)3.10342749
85negative regulation of RNA splicing (GO:0033119)3.09674140
86amino acid activation (GO:0043038)3.09108213
87tRNA aminoacylation (GO:0043039)3.09108213
88regulation of translational fidelity (GO:0006450)3.06240948
89regulation of helicase activity (GO:0051095)3.06181757
90protein complex localization (GO:0031503)3.04047970
91regulation of centrosome duplication (GO:0010824)3.02763426
92postreplication repair (GO:0006301)3.01696682
93regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98906735
94regulation of mitotic spindle checkpoint (GO:1903504)2.98906735
95replication fork processing (GO:0031297)2.98251448
96folic acid-containing compound biosynthetic process (GO:0009396)2.98040205
97telomere maintenance via telomere lengthening (GO:0010833)2.96796317
98nuclear envelope organization (GO:0006998)2.93470075
99DNA conformation change (GO:0071103)2.93142476
100chromosome segregation (GO:0007059)2.90514837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.05902796
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.74361635
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.50376001
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.72635255
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59534203
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.47081963
7AR_21909140_ChIP-Seq_LNCAP_Human3.24045275
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.15195214
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.09204588
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.76680058
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.62362748
12* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58653673
13ELK1_19687146_ChIP-ChIP_HELA_Human2.54195402
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53531114
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.51857020
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47758247
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42707511
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36731968
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33879914
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28911040
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.27561740
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24211097
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20339531
24YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19363436
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.11927159
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10694569
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10027400
28MYCN_18555785_ChIP-Seq_MESCs_Mouse2.08373495
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.98979247
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97260999
31DCP1A_22483619_ChIP-Seq_HELA_Human1.92464217
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88463088
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.79959620
34TTF2_22483619_ChIP-Seq_HELA_Human1.79112565
35VDR_23849224_ChIP-Seq_CD4+_Human1.76586349
36XRN2_22483619_ChIP-Seq_HELA_Human1.76026830
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74808219
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73590439
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73045375
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71272109
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71101596
42FOXP3_21729870_ChIP-Seq_TREG_Human1.68889989
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68395414
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68262086
45GABP_19822575_ChIP-Seq_HepG2_Human1.55283668
46EWS_26573619_Chip-Seq_HEK293_Human1.46183274
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45510535
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41875966
49FUS_26573619_Chip-Seq_HEK293_Human1.39902146
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39396283
51MYC_18940864_ChIP-ChIP_HL60_Human1.38862023
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37836228
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29187560
54NANOG_16153702_ChIP-ChIP_HESCs_Human1.28218788
55KDM5A_27292631_Chip-Seq_BREAST_Human1.28119037
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.22459343
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22293806
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.19207712
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18756025
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.16939262
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15595183
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15181981
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14276136
64SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12041140
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11165236
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10461140
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06976733
68SOX17_20123909_ChIP-Seq_XEN_Mouse1.06391569
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.04176770
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01325233
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99252398
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98879082
73NOTCH1_21737748_ChIP-Seq_TLL_Human0.97441562
74POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97091728
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96830385
76ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96580131
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94657146
78ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93687755
79CHD1_26751641_Chip-Seq_LNCaP_Human0.92736905
80WT1_19549856_ChIP-ChIP_CCG9911_Human0.92607596
81CIITA_25753668_ChIP-Seq_RAJI_Human0.92435292
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91916639
83KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90365098
84NANOG_21062744_ChIP-ChIP_HESCs_Human0.90069352
85TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89629831
86TFEB_21752829_ChIP-Seq_HELA_Human0.88004800
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86405817
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85068039
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85068039
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85068039
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84412233
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84298773
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84013672
94IGF1R_20145208_ChIP-Seq_DFB_Human0.81329904
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79944959
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.78121382
97ZNF274_21170338_ChIP-Seq_K562_Hela0.74915909
98TAF15_26573619_Chip-Seq_HEK293_Human0.74883649
99YY1_21170310_ChIP-Seq_MESCs_Mouse0.73896362
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72242975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.74060929
2MP0010094_abnormal_chromosome_stability4.62327765
3MP0003693_abnormal_embryo_hatching4.00490137
4MP0003111_abnormal_nucleus_morphology3.94986559
5MP0004957_abnormal_blastocyst_morpholog3.79226537
6MP0008058_abnormal_DNA_repair3.71826651
7MP0003077_abnormal_cell_cycle3.24598090
8MP0008932_abnormal_embryonic_tissue2.90853114
9MP0008007_abnormal_cellular_replicative2.54724302
10MP0001730_embryonic_growth_arrest2.24798638
11MP0003941_abnormal_skin_development2.24721849
12MP0009697_abnormal_copulation2.21334082
13MP0010352_gastrointestinal_tract_polyps2.07311162
14MP0003890_abnormal_embryonic-extraembry2.02894567
15MP0000350_abnormal_cell_proliferation1.83940760
16MP0003937_abnormal_limbs/digits/tail_de1.82802354
17MP0001293_anophthalmia1.82447706
18MP0001697_abnormal_embryo_size1.77788458
19MP0002084_abnormal_developmental_patter1.77276085
20MP0001672_abnormal_embryogenesis/_devel1.76322050
21MP0005380_embryogenesis_phenotype1.76322050
22MP0010307_abnormal_tumor_latency1.68986539
23MP0006292_abnormal_olfactory_placode1.68388761
24MP0009672_abnormal_birth_weight1.67798729
25MP0002085_abnormal_embryonic_tissue1.61252620
26MP0004197_abnormal_fetal_growth/weight/1.60043752
27MP0003718_maternal_effect1.56095191
28MP0002009_preneoplasia1.55381038
29MP0003984_embryonic_growth_retardation1.54853360
30MP0003786_premature_aging1.53929247
31MP0002088_abnormal_embryonic_growth/wei1.49163688
32MP0003567_abnormal_fetal_cardiomyocyte1.48115138
33MP0000537_abnormal_urethra_morphology1.47376569
34MP0002080_prenatal_lethality1.46329922
35MP0008877_abnormal_DNA_methylation1.45532199
36MP0002697_abnormal_eye_size1.39159640
37MP0005187_abnormal_penis_morphology1.32820552
38MP0002234_abnormal_pharynx_morphology1.32410807
39MP0009703_decreased_birth_body1.30547321
40MP0003221_abnormal_cardiomyocyte_apopto1.28031022
41MP0002233_abnormal_nose_morphology1.23603705
42MP0002086_abnormal_extraembryonic_tissu1.23557592
43MP0001286_abnormal_eye_development1.23009628
44MP0010030_abnormal_orbit_morphology1.19038583
45MP0001188_hyperpigmentation1.16980367
46MP0003119_abnormal_digestive_system1.15486159
47MP0000428_abnormal_craniofacial_morphol1.15115707
48MP0002111_abnormal_tail_morphology1.14914677
49MP0003315_abnormal_perineum_morphology1.12891531
50MP0002092_abnormal_eye_morphology1.12018955
51MP0000313_abnormal_cell_death1.11635991
52MP0008789_abnormal_olfactory_epithelium1.11376547
53MP0006035_abnormal_mitochondrial_morpho1.09281587
54MP0000647_abnormal_sebaceous_gland1.08134149
55MP0003121_genomic_imprinting1.07210795
56MP0002938_white_spotting1.06899257
57MP0006072_abnormal_retinal_apoptosis1.05893328
58MP0002102_abnormal_ear_morphology1.05833967
59MP0001299_abnormal_eye_distance/1.05744411
60MP0003385_abnormal_body_wall1.05068160
61MP0003755_abnormal_palate_morphology0.99863905
62MP0001529_abnormal_vocalization0.96451621
63MP0000358_abnormal_cell_content/0.93870027
64MP0003861_abnormal_nervous_system0.93238261
65MP0002751_abnormal_autonomic_nervous0.92189693
66MP0010234_abnormal_vibrissa_follicle0.91282839
67MP0001661_extended_life_span0.90590810
68MP0002396_abnormal_hematopoietic_system0.90581397
69MP0002877_abnormal_melanocyte_morpholog0.88860891
70MP0003935_abnormal_craniofacial_develop0.88333511
71MP0001177_atelectasis0.87589697
72MP0000049_abnormal_middle_ear0.85839790
73MP0002210_abnormal_sex_determination0.85702095
74MP0000432_abnormal_head_morphology0.85222499
75MP0010678_abnormal_skin_adnexa0.81809442
76MP0001929_abnormal_gametogenesis0.81233650
77MP0000516_abnormal_urinary_system0.79803509
78MP0005367_renal/urinary_system_phenotyp0.79803509
79MP0000579_abnormal_nail_morphology0.79400695
80MP0005499_abnormal_olfactory_system0.78538147
81MP0005394_taste/olfaction_phenotype0.78538147
82MP0005391_vision/eye_phenotype0.77954628
83MP0001145_abnormal_male_reproductive0.77291549
84MP0003942_abnormal_urinary_system0.76438641
85MP0000383_abnormal_hair_follicle0.73450314
86MP0004233_abnormal_muscle_weight0.71945422
87MP0002081_perinatal_lethality0.71315989
88MP0005384_cellular_phenotype0.71170508
89MP0000653_abnormal_sex_gland0.69692895
90MP0004185_abnormal_adipocyte_glucose0.68629306
91MP0001346_abnormal_lacrimal_gland0.67392624
92MP0005248_abnormal_Harderian_gland0.66495123
93MP0004272_abnormal_basement_membrane0.65839855
94MP0002114_abnormal_axial_skeleton0.64932965
95MP0002177_abnormal_outer_ear0.64766032
96MP0005501_abnormal_skin_physiology0.64702997
97MP0002019_abnormal_tumor_incidence0.64000904
98MP0005623_abnormal_meninges_morphology0.63639626
99MP0003943_abnormal_hepatobiliary_system0.63286977
100MP0008995_early_reproductive_senescence0.62747335

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.42286116
2Chromsome breakage (HP:0040012)4.39617431
3Cortical dysplasia (HP:0002539)3.66983740
4Abnormality of chromosome stability (HP:0003220)3.58795772
5Nephroblastoma (Wilms tumor) (HP:0002667)3.34539593
6Ependymoma (HP:0002888)3.31247791
7Meckel diverticulum (HP:0002245)3.31133722
8Medulloblastoma (HP:0002885)3.29998361
9Rhabdomyosarcoma (HP:0002859)3.27424335
10Embryonal renal neoplasm (HP:0011794)3.24269159
11Volvulus (HP:0002580)3.20840891
12Colon cancer (HP:0003003)3.20382098
13Abnormality of the ileum (HP:0001549)3.16651910
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.11796629
15Abnormal lung lobation (HP:0002101)3.07006398
16Abnormality of the preputium (HP:0100587)2.97781122
17Increased nuchal translucency (HP:0010880)2.95660980
18Glioma (HP:0009733)2.86648208
19Abnormality of the astrocytes (HP:0100707)2.86294054
20Astrocytoma (HP:0009592)2.86294054
21Small intestinal stenosis (HP:0012848)2.76364805
22Duodenal stenosis (HP:0100867)2.76364805
23Multiple enchondromatosis (HP:0005701)2.56616942
24Ectopic kidney (HP:0000086)2.56332017
25Papillary thyroid carcinoma (HP:0002895)2.47109897
26Abnormality of the labia minora (HP:0012880)2.46494053
27Myelodysplasia (HP:0002863)2.42714013
28Neoplasm of the colon (HP:0100273)2.42436522
29Abnormality of the duodenum (HP:0002246)2.42340063
30Birth length less than 3rd percentile (HP:0003561)2.41583694
31Sloping forehead (HP:0000340)2.27305417
32Neoplasm of striated muscle (HP:0009728)2.27135188
33Abnormality of the carotid arteries (HP:0005344)2.23070373
34Cafe-au-lait spot (HP:0000957)2.17569105
35Aplasia/Hypoplasia of the sternum (HP:0006714)2.15890872
36High anterior hairline (HP:0009890)2.14984440
37Biliary tract neoplasm (HP:0100574)2.14363390
38Neoplasm of the small intestine (HP:0100833)2.10200658
39Embryonal neoplasm (HP:0002898)2.09690020
40Abnormality of methionine metabolism (HP:0010901)2.04233014
41Progressive external ophthalmoplegia (HP:0000590)2.03096161
42Absent radius (HP:0003974)2.01079651
43Proximal placement of thumb (HP:0009623)1.99751126
44Neoplasm of the adrenal gland (HP:0100631)1.99048716
45Spastic diplegia (HP:0001264)1.98708231
46Microvesicular hepatic steatosis (HP:0001414)1.97095749
47Triphalangeal thumb (HP:0001199)1.92648793
48Ovarian neoplasm (HP:0100615)1.92451672
49Deviation of the thumb (HP:0009603)1.91978888
50Hepatoblastoma (HP:0002884)1.91723150
51Facial cleft (HP:0002006)1.90060672
52Absent forearm bone (HP:0003953)1.87767625
53Aplasia involving forearm bones (HP:0009822)1.87767625
54Gonadotropin excess (HP:0000837)1.86874092
55Abnormality of the anterior horn cell (HP:0006802)1.84926591
56Degeneration of anterior horn cells (HP:0002398)1.84926591
57Arteriovenous malformation (HP:0100026)1.84500339
58Selective tooth agenesis (HP:0001592)1.83488499
59Horseshoe kidney (HP:0000085)1.83252364
60Thyroid carcinoma (HP:0002890)1.83235120
61Microglossia (HP:0000171)1.81845482
62Abnormality of glycolysis (HP:0004366)1.80133796
63Choanal atresia (HP:0000453)1.80014487
64Gastrointestinal carcinoma (HP:0002672)1.79145884
65Malignant gastrointestinal tract tumors (HP:0006749)1.79145884
66Neoplasm of the adrenal cortex (HP:0100641)1.76659168
67Nervous tissue neoplasm (HP:0030060)1.76344804
68Neuroectodermal neoplasm (HP:0030061)1.76344804
69Neuroepithelial neoplasm (HP:0030063)1.76344804
70Neuroblastic tumors (HP:0004376)1.76286771
71Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.76286771
72Neuroblastoma (HP:0003006)1.76286771
73Primitive neuroectodermal tumor (HP:0030065)1.76286771
74Deep philtrum (HP:0002002)1.75116467
75Uterine neoplasm (HP:0010784)1.71565906
76Breast carcinoma (HP:0003002)1.70288347
77Malignant neoplasm of the central nervous system (HP:0100836)1.69380947
78Postnatal microcephaly (HP:0005484)1.67980197
79Bifid tongue (HP:0010297)1.67527070
80Clubbing of toes (HP:0100760)1.65392429
81Neoplasm of the rectum (HP:0100743)1.64904427
82Abnormality of chromosome segregation (HP:0002916)1.62108085
83Intestinal atresia (HP:0011100)1.59005093
84Skull defect (HP:0001362)1.58785679
85Increased serum pyruvate (HP:0003542)1.55962390
86Overlapping toe (HP:0001845)1.55656476
87Missing ribs (HP:0000921)1.53885651
88Prominent metopic ridge (HP:0005487)1.52909288
89Reticulocytopenia (HP:0001896)1.52674487
90Intestinal polyposis (HP:0200008)1.51656929
91Agnosia (HP:0010524)1.51362612
92Pancreatic islet-cell hyperplasia (HP:0004510)1.51337883
93Acute myeloid leukemia (HP:0004808)1.51270553
94Neoplasm of the oral cavity (HP:0100649)1.51203475
95Progressive muscle weakness (HP:0003323)1.48142155
96Abnormal biliary tract morphology (HP:0012440)1.48068806
97Megaloblastic anemia (HP:0001889)1.46981505
98Abnormality of cochlea (HP:0000375)1.46336975
99Cystic hygroma (HP:0000476)1.45414305
100Abnormality of the metopic suture (HP:0005556)1.45212210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.83950854
2BUB13.83536732
3SRPK13.82492081
4TTK3.52648398
5NEK13.18204723
6TSSK63.03504897
7TRIM282.92895778
8MKNK12.85271600
9EIF2AK12.59474520
10WEE12.54169186
11MKNK22.52527353
12EIF2AK32.52022736
13PLK42.38173095
14PLK32.33602725
15PBK2.33424070
16ERBB32.28298587
17BRSK22.03680260
18BCR1.81020693
19PLK11.64259077
20LATS11.63234068
21ZAK1.55519060
22BRD41.54595067
23MST41.53965907
24TNIK1.46569199
25NUAK11.46410836
26ATR1.42133160
27TAF11.38919523
28CHEK21.34039928
29EIF2AK21.23625096
30SCYL21.22118026
31NEK21.21220887
32AURKB1.18262694
33VRK21.18246126
34MAP3K101.11173352
35PNCK1.09209712
36CHEK11.09190478
37ATM1.08618783
38BRSK11.07214315
39STK31.06602543
40STK38L1.06214681
41PASK1.00949659
42EEF2K0.98689346
43CLK10.96785359
44CDK70.94633807
45VRK10.92112637
46FGFR10.85258254
47RPS6KA40.84304644
48ALK0.83498108
49MAP4K20.80634203
50ERBB40.79040061
51RPS6KB20.78821415
52CSNK1G10.78038734
53PLK20.76386472
54CDK60.72815296
55STK160.71355737
56CDK10.70892864
57CCNB10.69642712
58CSNK1A1L0.69637948
59PAK40.68938572
60SIK30.67905339
61CSNK1G30.65879246
62CDK20.65423094
63WNK30.61335096
64MAP3K40.59468053
65DYRK30.57512661
66BMPR1B0.57014125
67CSNK1E0.56794381
68CDK80.56132438
69NME20.56086781
70CDK30.53847938
71LATS20.52235316
72CSNK2A20.51720919
73MAP3K80.51426791
74TGFBR10.50072995
75CDK120.49870935
76PRKDC0.49764798
77CSNK1G20.48564401
78AURKA0.47842462
79MET0.47632712
80SMG10.45333227
81STK390.44663406
82STK40.43964840
83BRAF0.42686672
84CDK180.41862983
85CSNK2A10.41558766
86CDK90.41240583
87FLT30.41184829
88NME10.40600529
89RAF10.34729469
90PDGFRA0.34566066
91CDK140.33433927
92CDK150.33299166
93CDK40.32988458
94KSR10.32972536
95CAMK1G0.30294075
96STK100.29877377
97YES10.29695986
98MST1R0.29647188
99AKT20.29276874
100CDK11A0.28215991

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.10447961
2Non-homologous end-joining_Homo sapiens_hsa034503.86288814
3Mismatch repair_Homo sapiens_hsa034303.81144690
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.48772623
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41648284
6RNA transport_Homo sapiens_hsa030132.96282164
7Spliceosome_Homo sapiens_hsa030402.86907293
8Cell cycle_Homo sapiens_hsa041102.80244142
9Fanconi anemia pathway_Homo sapiens_hsa034602.46194325
10Proteasome_Homo sapiens_hsa030502.45985715
11Homologous recombination_Homo sapiens_hsa034402.41782044
12Nucleotide excision repair_Homo sapiens_hsa034202.33522485
13Base excision repair_Homo sapiens_hsa034102.32147983
14One carbon pool by folate_Homo sapiens_hsa006702.22499864
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.20551646
16mRNA surveillance pathway_Homo sapiens_hsa030152.02967181
17Basal transcription factors_Homo sapiens_hsa030221.98156622
18RNA degradation_Homo sapiens_hsa030181.92512059
19RNA polymerase_Homo sapiens_hsa030201.90527136
20Protein export_Homo sapiens_hsa030601.82173715
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.75637851
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71012054
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60445221
24Propanoate metabolism_Homo sapiens_hsa006401.54735278
25Biosynthesis of amino acids_Homo sapiens_hsa012301.49032887
26Pyruvate metabolism_Homo sapiens_hsa006201.44672715
27Selenocompound metabolism_Homo sapiens_hsa004501.44351563
28Pyrimidine metabolism_Homo sapiens_hsa002401.42111538
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34387204
30Steroid biosynthesis_Homo sapiens_hsa001001.31395530
31Oocyte meiosis_Homo sapiens_hsa041141.27290257
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24914412
33p53 signaling pathway_Homo sapiens_hsa041151.19758455
34Carbon metabolism_Homo sapiens_hsa012001.17373032
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16545525
36Vitamin B6 metabolism_Homo sapiens_hsa007501.06969285
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03533066
38Fatty acid elongation_Homo sapiens_hsa000621.03024315
39Purine metabolism_Homo sapiens_hsa002301.00334419
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95382880
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91791231
42Ribosome_Homo sapiens_hsa030100.90765417
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90221779
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86710901
45Adherens junction_Homo sapiens_hsa045200.86624323
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85454391
47Lysine degradation_Homo sapiens_hsa003100.85135199
48Thyroid cancer_Homo sapiens_hsa052160.82918580
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81598715
50Hippo signaling pathway_Homo sapiens_hsa043900.80610911
51MicroRNAs in cancer_Homo sapiens_hsa052060.78682196
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74705436
53TGF-beta signaling pathway_Homo sapiens_hsa043500.70967134
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62444809
55Colorectal cancer_Homo sapiens_hsa052100.60259559
56Wnt signaling pathway_Homo sapiens_hsa043100.60074241
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58431570
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.57812203
59Basal cell carcinoma_Homo sapiens_hsa052170.57665176
60N-Glycan biosynthesis_Homo sapiens_hsa005100.56326749
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53660865
62Folate biosynthesis_Homo sapiens_hsa007900.53056446
63Fatty acid metabolism_Homo sapiens_hsa012120.51524946
64Pentose phosphate pathway_Homo sapiens_hsa000300.49256131
65Tight junction_Homo sapiens_hsa045300.48971392
66Hedgehog signaling pathway_Homo sapiens_hsa043400.46714264
67Viral carcinogenesis_Homo sapiens_hsa052030.44517306
68Epstein-Barr virus infection_Homo sapiens_hsa051690.44223858
69Glutathione metabolism_Homo sapiens_hsa004800.40445613
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39462733
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39035248
72Prostate cancer_Homo sapiens_hsa052150.35260540
73Huntingtons disease_Homo sapiens_hsa050160.35013316
74Metabolic pathways_Homo sapiens_hsa011000.34435355
75Arginine and proline metabolism_Homo sapiens_hsa003300.33372524
76Small cell lung cancer_Homo sapiens_hsa052220.32819220
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30819105
78Alcoholism_Homo sapiens_hsa050340.28927974
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28709552
80Melanoma_Homo sapiens_hsa052180.25936953
81Parkinsons disease_Homo sapiens_hsa050120.25508371
82Chronic myeloid leukemia_Homo sapiens_hsa052200.25160245
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24160507
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23538002
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18972021
86Butanoate metabolism_Homo sapiens_hsa006500.18510139
87Proteoglycans in cancer_Homo sapiens_hsa052050.15219853
88AMPK signaling pathway_Homo sapiens_hsa041520.13220621
89Bladder cancer_Homo sapiens_hsa052190.13108658
90Pathways in cancer_Homo sapiens_hsa052000.12101793
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11871403
92HTLV-I infection_Homo sapiens_hsa051660.11401201
93Herpes simplex infection_Homo sapiens_hsa051680.11219281
94Endometrial cancer_Homo sapiens_hsa052130.09728860
95Peroxisome_Homo sapiens_hsa041460.08673458
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.07855375
97Glioma_Homo sapiens_hsa052140.06390319
98Systemic lupus erythematosus_Homo sapiens_hsa053220.05905660
99Pancreatic cancer_Homo sapiens_hsa052120.05650946
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05269369

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