ZNF148

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.84373217
2neural tube formation (GO:0001841)4.54185108
3protein K11-linked deubiquitination (GO:0035871)4.34249631
4monoubiquitinated protein deubiquitination (GO:0035520)4.00301325
5establishment of protein localization to Golgi (GO:0072600)3.97028430
6protein targeting to Golgi (GO:0000042)3.82391158
7retrograde transport, vesicle recycling within Golgi (GO:0000301)3.81437923
8cytoplasmic mRNA processing body assembly (GO:0033962)3.70178174
9regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.53938394
10regulation of pigment cell differentiation (GO:0050932)3.37908793
11interleukin-6-mediated signaling pathway (GO:0070102)3.37301436
12genitalia morphogenesis (GO:0035112)3.33812799
13embryonic retina morphogenesis in camera-type eye (GO:0060059)3.32979173
14histone H3-K4 trimethylation (GO:0080182)3.27663171
15peptidyl-lysine trimethylation (GO:0018023)3.26512457
16mitochondrion distribution (GO:0048311)3.21865572
17protein prenylation (GO:0018342)3.16182059
18prenylation (GO:0097354)3.16182059
19Golgi to endosome transport (GO:0006895)3.13734851
20keratinocyte development (GO:0003334)3.12403359
21central nervous system projection neuron axonogenesis (GO:0021952)3.09673178
22microtubule anchoring (GO:0034453)3.08810632
23nerve growth factor signaling pathway (GO:0038180)3.08689801
24mitotic sister chromatid cohesion (GO:0007064)3.00193621
25interkinetic nuclear migration (GO:0022027)2.99615893
26regulation of sarcomere organization (GO:0060297)2.99561544
27central nervous system neuron axonogenesis (GO:0021955)2.99373669
28presynaptic membrane assembly (GO:0097105)2.92267322
29pyrimidine nucleobase catabolic process (GO:0006208)2.84878773
30protein localization to Golgi apparatus (GO:0034067)2.78188317
31positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.76606303
32regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.76606303
33negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.74442747
34regulation of DNA endoreduplication (GO:0032875)2.73685493
35regulation of Rac protein signal transduction (GO:0035020)2.69764709
36hepatocyte apoptotic process (GO:0097284)2.66686663
37negative regulation of neurotransmitter transport (GO:0051589)2.66464516
38microtubule nucleation (GO:0007020)2.65410563
39phospholipid translocation (GO:0045332)2.65176739
40lipid translocation (GO:0034204)2.65176739
41intra-Golgi vesicle-mediated transport (GO:0006891)2.61442049
42protein K48-linked deubiquitination (GO:0071108)2.61056107
43early endosome to late endosome transport (GO:0045022)2.60675173
44cerebral cortex radially oriented cell migration (GO:0021799)2.59061832
45positive regulation of cardiac muscle cell differentiation (GO:2000727)2.58116906
46regulation of protein glycosylation (GO:0060049)2.57183223
47myelin assembly (GO:0032288)2.55461376
48positive regulation of muscle hypertrophy (GO:0014742)2.55407478
49positive regulation of cardiac muscle hypertrophy (GO:0010613)2.55407478
50nucleus localization (GO:0051647)2.50033211
51nucleobase catabolic process (GO:0046113)2.49816310
52positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.49100169
53mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.49100169
54negative regulation of mast cell activation (GO:0033004)2.46544362
55regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.46229655
56positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.46229655
57regulation of establishment of cell polarity (GO:2000114)2.45691808
58histone mRNA catabolic process (GO:0071044)2.45020693
59protein K63-linked deubiquitination (GO:0070536)2.44864846
60positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.44678974
61protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.44520284
62pericardium development (GO:0060039)2.42852465
63regulation of fibroblast apoptotic process (GO:2000269)2.42009692
64centrosome duplication (GO:0051298)2.41564100
65acrosome assembly (GO:0001675)2.41358644
66cellular response to ethanol (GO:0071361)2.40200291
67dentate gyrus development (GO:0021542)2.39599429
68regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.39270076
69negative regulation of neurotransmitter secretion (GO:0046929)2.38981719
70regulation of keratinocyte proliferation (GO:0010837)2.37461162
71nuclear pore complex assembly (GO:0051292)2.35060607
72presynaptic membrane organization (GO:0097090)2.34489446
73heart field specification (GO:0003128)2.34400084
74secondary heart field specification (GO:0003139)2.34400084
75negative regulation of dendrite development (GO:2000171)2.32827291
76relaxation of smooth muscle (GO:0044557)2.32363020
77gastrulation with mouth forming second (GO:0001702)2.32295258
78limb bud formation (GO:0060174)2.32222557
79eye photoreceptor cell differentiation (GO:0001754)2.31699094
80photoreceptor cell differentiation (GO:0046530)2.31699094
81Golgi to plasma membrane protein transport (GO:0043001)2.30633329
82regulation of clathrin-mediated endocytosis (GO:2000369)2.30301878
83cerebral cortex cell migration (GO:0021795)2.30170723
84oocyte development (GO:0048599)2.29857154
85embryonic epithelial tube formation (GO:0001838)2.29542956
86regulation of energy homeostasis (GO:2000505)2.29226703
87nuclear pore organization (GO:0006999)2.28325058
88regulation of skeletal muscle cell differentiation (GO:2001014)2.28122458
89intestinal epithelial cell development (GO:0060576)2.26268767
90peptidyl-lysine methylation (GO:0018022)2.26045943
91morphogenesis of an epithelial sheet (GO:0002011)2.25967166
92smooth muscle tissue development (GO:0048745)2.25613376
93regulation of mRNA 3-end processing (GO:0031440)2.25602598
94positive regulation of myoblast differentiation (GO:0045663)2.25232727
95olfactory bulb development (GO:0021772)2.24923673
96regulation of DNA-templated transcription, initiation (GO:2000142)2.24907289
97regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.24293728
98iron ion import (GO:0097286)2.22425319
99vascular smooth muscle contraction (GO:0014829)2.21799001
100histone H3-K36 demethylation (GO:0070544)2.21584581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.47535823
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.24712797
3GBX2_23144817_ChIP-Seq_PC3_Human3.14718101
4POU3F2_20337985_ChIP-ChIP_501MEL_Human3.13601889
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.97655659
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.93227087
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.83688428
8TAF15_26573619_Chip-Seq_HEK293_Human2.61370020
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59649914
10AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.45803407
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43379740
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.37824628
13FUS_26573619_Chip-Seq_HEK293_Human2.21659093
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08129111
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03372191
16P300_19829295_ChIP-Seq_ESCs_Human2.02956223
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.99614375
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.97255660
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96422144
20* SMAD4_21799915_ChIP-Seq_A2780_Human1.94091981
21OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.93450398
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92655732
23IGF1R_20145208_ChIP-Seq_DFB_Human1.92083547
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91297348
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.86467735
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.81872233
27TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.72827145
28EWS_26573619_Chip-Seq_HEK293_Human1.72768046
29STAT3_23295773_ChIP-Seq_U87_Human1.69809079
30ER_23166858_ChIP-Seq_MCF-7_Human1.69526634
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68323300
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.67957169
33FOXM1_26456572_ChIP-Seq_MCF-7_Human1.66507892
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56443438
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.55270691
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54508603
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53316571
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53316571
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53088677
40TCF4_23295773_ChIP-Seq_U87_Human1.51800861
41CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.51693014
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51464775
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.50667681
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50529110
45TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49845055
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49669673
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.48522636
48E2F1_18555785_Chip-Seq_ESCs_Mouse1.46869903
49AR_25329375_ChIP-Seq_VCAP_Human1.45852634
50AHR_22903824_ChIP-Seq_MCF-7_Human1.44807024
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44366233
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42182401
53P53_22387025_ChIP-Seq_ESCs_Mouse1.41083172
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39187919
55TP53_16413492_ChIP-PET_HCT116_Human1.37515030
56BCAT_22108803_ChIP-Seq_LS180_Human1.35635879
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35328961
58CMYC_18555785_Chip-Seq_ESCs_Mouse1.34952110
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34926036
60EZH2_22144423_ChIP-Seq_EOC_Human1.34210826
61CBP_20019798_ChIP-Seq_JUKART_Human1.30205815
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30205815
63FLI1_21867929_ChIP-Seq_TH2_Mouse1.30179726
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.29708972
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28312710
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.27511881
67VDR_22108803_ChIP-Seq_LS180_Human1.27334032
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26639792
69ZNF274_21170338_ChIP-Seq_K562_Hela1.23411923
70CJUN_26792858_Chip-Seq_BT549_Human1.23184023
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21625309
72CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21430163
73TP53_18474530_ChIP-ChIP_U2OS_Human1.17242287
74AR_21572438_ChIP-Seq_LNCaP_Human1.17232558
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17218086
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17218086
77* RUNX2_22187159_ChIP-Seq_PCA_Human1.17026502
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.16990038
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16066799
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15130491
81TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14612700
82P300_18555785_Chip-Seq_ESCs_Mouse1.14464791
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13825076
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.13739291
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.13541975
86KDM2B_26808549_Chip-Seq_REH_Human1.13470547
87TCF4_22108803_ChIP-Seq_LS180_Human1.12910891
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.12406305
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12077204
90CDX2_22108803_ChIP-Seq_LS180_Human1.11955255
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10727479
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.10198823
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.10143841
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09718218
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.09091211
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.08628024
97SOX2_18555785_Chip-Seq_ESCs_Mouse1.06938640
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06384343
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.05729849
100BRD4_25478319_ChIP-Seq_HGPS_Human1.03261400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.91237214
2MP0008057_abnormal_DNA_replication4.04548987
3MP0002009_preneoplasia3.28770518
4MP0009780_abnormal_chondrocyte_physiolo2.81933195
5MP0003787_abnormal_imprinting2.78984481
6MP0010678_abnormal_skin_adnexa2.73104511
7MP0000383_abnormal_hair_follicle2.67336209
8MP0000427_abnormal_hair_cycle2.64581678
9MP0003252_abnormal_bile_duct2.58295894
10MP0008877_abnormal_DNA_methylation2.29823416
11MP0003880_abnormal_central_pattern2.25881485
12MP0005187_abnormal_penis_morphology2.20270630
13MP0002928_abnormal_bile_duct2.11540225
14MP0010234_abnormal_vibrissa_follicle1.85212714
15MP0005248_abnormal_Harderian_gland1.83739012
16MP0006072_abnormal_retinal_apoptosis1.81293213
17MP0004885_abnormal_endolymph1.81192820
18MP0010352_gastrointestinal_tract_polyps1.76717919
19MP0005174_abnormal_tail_pigmentation1.65817102
20MP0003868_abnormal_feces_composition1.59015462
21MP0002909_abnormal_adrenal_gland1.50972647
22MP0003890_abnormal_embryonic-extraembry1.50651148
23MP0005253_abnormal_eye_physiology1.48090434
24MP0000778_abnormal_nervous_system1.40751602
25MP0002166_altered_tumor_susceptibility1.39628691
26MP0003656_abnormal_erythrocyte_physiolo1.39438956
27MP0004134_abnormal_chest_morphology1.39323036
28MP0003121_genomic_imprinting1.38294897
29MP0003943_abnormal_hepatobiliary_system1.37868710
30MP0005386_behavior/neurological_phenoty1.36734751
31MP0004924_abnormal_behavior1.36734751
32MP0003950_abnormal_plasma_membrane1.34610357
33MP0001486_abnormal_startle_reflex1.34222565
34MP0005275_abnormal_skin_tensile1.33756539
35MP0001879_abnormal_lymphatic_vessel1.29215832
36MP0000013_abnormal_adipose_tissue1.28845251
37MP0004484_altered_response_of1.28065104
38MP0003183_abnormal_peptide_metabolism1.26226303
39MP0003724_increased_susceptibility_to1.20020238
40MP0000647_abnormal_sebaceous_gland1.19572195
41MP0002396_abnormal_hematopoietic_system1.13592609
42MP0004084_abnormal_cardiac_muscle1.09461340
43MP0000015_abnormal_ear_pigmentation1.09193331
44MP0004883_abnormal_blood_vessel1.07795675
45MP0009697_abnormal_copulation1.07502811
46MP0005409_darkened_coat_color1.07465925
47MP0005084_abnormal_gallbladder_morpholo1.05925203
48MP0003195_calcinosis1.03336375
49MP0003935_abnormal_craniofacial_develop1.02119685
50MP0002102_abnormal_ear_morphology1.00298143
51MP0004270_analgesia0.98603328
52MP0003633_abnormal_nervous_system0.95592351
53MP0006276_abnormal_autonomic_nervous0.93798615
54MP0003755_abnormal_palate_morphology0.93395959
55MP0004043_abnormal_pH_regulation0.93295980
56MP0000631_abnormal_neuroendocrine_gland0.92127850
57MP0000465_gastrointestinal_hemorrhage0.92005684
58MP0002233_abnormal_nose_morphology0.91684355
59MP0002638_abnormal_pupillary_reflex0.90732350
60MP0002751_abnormal_autonomic_nervous0.90617396
61MP0000372_irregular_coat_pigmentation0.87671495
62MP0004215_abnormal_myocardial_fiber0.87029350
63MP0001177_atelectasis0.85145751
64MP0002168_other_aberrant_phenotype0.85104969
65MP0005391_vision/eye_phenotype0.84603287
66MP0002006_tumorigenesis0.84255822
67MP0002095_abnormal_skin_pigmentation0.83774044
68MP0003221_abnormal_cardiomyocyte_apopto0.83155845
69MP0003091_abnormal_cell_migration0.82763402
70MP0005503_abnormal_tendon_morphology0.82627625
71MP0000516_abnormal_urinary_system0.81673043
72MP0005367_renal/urinary_system_phenotyp0.81673043
73MP0002234_abnormal_pharynx_morphology0.81362992
74MP0002067_abnormal_sensory_capabilities0.79319949
75MP0002127_abnormal_cardiovascular_syste0.76903731
76MP0002177_abnormal_outer_ear0.76708203
77MP0005646_abnormal_pituitary_gland0.76388082
78MP0005551_abnormal_eye_electrophysiolog0.74056461
79MP0001851_eye_inflammation0.71218337
80MP0000462_abnormal_digestive_system0.70963978
81MP0003631_nervous_system_phenotype0.70656964
82MP0003045_fibrosis0.69683065
83MP0002572_abnormal_emotion/affect_behav0.69452133
84MP0003635_abnormal_synaptic_transmissio0.69306743
85MP0000428_abnormal_craniofacial_morphol0.69285955
86MP0001984_abnormal_olfaction0.69072100
87MP0004142_abnormal_muscle_tone0.67107246
88MP0008775_abnormal_heart_ventricle0.66935029
89MP0004808_abnormal_hematopoietic_stem0.66494771
90MP0005379_endocrine/exocrine_gland_phen0.64874244
91MP0002063_abnormal_learning/memory/cond0.64364082
92MP0002109_abnormal_limb_morphology0.63772532
93MP0002735_abnormal_chemical_nociception0.63579734
94MP0004085_abnormal_heartbeat0.63098297
95MP0001756_abnormal_urination0.62618188
96MP0000371_diluted_coat_color0.59898010
97MP0009745_abnormal_behavioral_response0.59747027
98MP0003300_gastrointestinal_ulcer0.59590008
99MP0001286_abnormal_eye_development0.59129805
100MP0009703_decreased_birth_body0.58942941

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)5.46632903
2Volvulus (HP:0002580)4.06860765
3Thyroid carcinoma (HP:0002890)3.97942696
4Hyperventilation (HP:0002883)3.94434609
5Febrile seizures (HP:0002373)3.51218694
6Subacute progressive viral hepatitis (HP:0006572)3.50095025
7Fair hair (HP:0002286)3.48026872
8Aplasia/Hypoplasia of the tibia (HP:0005772)3.43035865
9Short tibia (HP:0005736)3.11184183
10Drooling (HP:0002307)3.04695288
11Absent frontal sinuses (HP:0002688)2.89222868
12Excessive salivation (HP:0003781)2.88297313
13Generalized hypopigmentation of hair (HP:0011358)2.77582046
14Short chin (HP:0000331)2.70721590
15Hypothermia (HP:0002045)2.70581262
16Tubulointerstitial nephritis (HP:0001970)2.45501985
17Abnormality of the ischium (HP:0003174)2.43063968
18Thyroiditis (HP:0100646)2.41157664
19Abnormality of the astrocytes (HP:0100707)2.37828800
20Astrocytoma (HP:0009592)2.37828800
21Stomach cancer (HP:0012126)2.37793586
22Hip dysplasia (HP:0001385)2.35295677
23Widely spaced teeth (HP:0000687)2.35119493
24Biliary tract neoplasm (HP:0100574)2.32148952
25Truncal obesity (HP:0001956)2.31490551
26Abnormal biliary tract morphology (HP:0012440)2.31211957
27Glioma (HP:0009733)2.29445369
28Medial flaring of the eyebrow (HP:0010747)2.28627583
29Intestinal atresia (HP:0011100)2.27518784
30Progressive cerebellar ataxia (HP:0002073)2.23067652
31Rhabdomyosarcoma (HP:0002859)2.19586718
32Gaze-evoked nystagmus (HP:0000640)2.19237175
33Tented upper lip vermilion (HP:0010804)2.18556533
34Protruding tongue (HP:0010808)2.17672657
35Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.16840922
36Pheochromocytoma (HP:0002666)2.16068096
37Neoplasm of the small intestine (HP:0100833)2.14585921
38Dyskinesia (HP:0100660)2.12797255
39Abnormal hair whorl (HP:0010721)2.12764052
40Genital tract atresia (HP:0001827)2.12715609
41Fibular hypoplasia (HP:0003038)2.12241781
42Neoplasm of the thyroid gland (HP:0100031)2.10526768
43Metaphyseal dysplasia (HP:0100255)2.07017216
44Large earlobe (HP:0009748)2.06676200
45Micronodular cirrhosis (HP:0001413)2.05901644
46Gait imbalance (HP:0002141)2.05243900
47Medulloblastoma (HP:0002885)2.04794084
48Overgrowth (HP:0001548)2.04378251
49Congenital primary aphakia (HP:0007707)2.03819170
50Hypoplastic ischia (HP:0003175)2.00907043
51Action tremor (HP:0002345)2.00576656
52Blue irides (HP:0000635)1.98702239
53Atonic seizures (HP:0010819)1.96352066
54Nephrogenic diabetes insipidus (HP:0009806)1.96194443
55Focal seizures (HP:0007359)1.94068548
56Menstrual irregularities (HP:0000858)1.90761938
57Arthropathy (HP:0003040)1.89647130
58Viral hepatitis (HP:0006562)1.89593515
59Termporal pattern (HP:0011008)1.89371933
60Insidious onset (HP:0003587)1.89371933
61Cystic hygroma (HP:0000476)1.89087274
62Broad-based gait (HP:0002136)1.88733080
63Abnormality of salivation (HP:0100755)1.88609471
64Neuroendocrine neoplasm (HP:0100634)1.86579821
65Neonatal respiratory distress (HP:0002643)1.86343755
66Poor coordination (HP:0002370)1.85077104
67Poor eye contact (HP:0000817)1.83518005
68Hemiparesis (HP:0001269)1.82984402
69Aqueductal stenosis (HP:0002410)1.81333086
70Vaginal atresia (HP:0000148)1.81318335
71Aplasia/Hypoplasia of the fibula (HP:0006492)1.78851844
72Abnormality of the axillary hair (HP:0100134)1.78524585
73Abnormality of secondary sexual hair (HP:0009888)1.78524585
74Abnormality of chromosome stability (HP:0003220)1.78224684
75Absent speech (HP:0001344)1.78189045
76Curly hair (HP:0002212)1.76585753
77Transitional cell carcinoma of the bladder (HP:0006740)1.76387766
78Bladder neoplasm (HP:0009725)1.75808928
79Bladder carcinoma (HP:0002862)1.75808928
80Midline defect of the nose (HP:0004122)1.75343289
81Subaortic stenosis (HP:0001682)1.75303926
82Abnormality of the left ventricular outflow tract (HP:0011103)1.75303926
83Oligodactyly (hands) (HP:0001180)1.73690483
84Neoplasm of striated muscle (HP:0009728)1.72722383
85Abnormal auditory evoked potentials (HP:0006958)1.72574292
86Abnormality of the frontal sinuses (HP:0002687)1.71553791
87Neoplasm of the peripheral nervous system (HP:0100007)1.71256770
88Acute myeloid leukemia (HP:0004808)1.70472420
89Choroideremia (HP:0001139)1.69780935
90Amyotrophic lateral sclerosis (HP:0007354)1.68622540
91Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.68568749
92Hamartoma of the eye (HP:0010568)1.66879316
93Short foot (HP:0001773)1.66443593
94Anhidrosis (HP:0000970)1.65100339
95Median cleft lip (HP:0000161)1.60769792
96Gastroesophageal reflux (HP:0002020)1.60706549
97Increased circulating renin level (HP:0000848)1.60417007
98Genetic anticipation (HP:0003743)1.60336886
99Hypoplastic iliac wings (HP:0002866)1.59864681
100Relative macrocephaly (HP:0004482)1.59582282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.17556383
2MAP3K123.09890012
3CASK2.84167630
4ERBB32.67981179
5BRD42.05501014
6TNIK2.05154476
7WNK32.03267078
8LATS12.03068864
9STK38L1.94651726
10MAP3K41.90488071
11PIK3CG1.89362707
12SGK21.89213745
13BMPR1B1.86484788
14NLK1.82705614
15MST41.81140488
16PNCK1.78226696
17TAOK31.77599261
18CCNB11.76643793
19MAPK131.74675767
20PLK21.72905506
21STK391.72038303
22MARK11.62370860
23AKT31.55401987
24NUAK11.54042773
25PIK3CA1.50108891
26TRPM71.45217473
27EPHA31.44670776
28FER1.33813677
29ACVR1B1.22491654
30MAP4K21.19091177
31SGK31.13425464
32CAMKK21.13206379
33BMPR21.12228180
34MAP2K41.11643953
35BCR1.11249268
36BRSK21.10614026
37PRKCE1.10330792
38EIF2AK31.09896552
39PAK31.09123819
40CSNK1G11.08148019
41OXSR11.07171290
42JAK11.04551798
43STK31.04201485
44OBSCN1.03108516
45NEK91.02113063
46IRAK11.01577730
47SGK4941.00843071
48SGK2231.00843071
49MAP2K70.97983427
50YES10.95975892
51PINK10.95689779
52NEK60.94899655
53TEC0.94226270
54FGFR30.82315202
55CDK30.82280833
56INSRR0.73412477
57STK240.73304583
58SCYL20.72621472
59WNK10.69061175
60MAP3K140.68463576
61PKN10.66494676
62CSNK1G20.65899325
63MAP3K20.65548790
64MKNK20.64954737
65TGFBR10.62207567
66CSNK1A1L0.58493889
67MAP3K100.57364349
68STK380.56901682
69TRIM280.55012119
70MYLK0.52601768
71RPS6KB10.52514916
72SGK10.51527025
73CDK120.51520044
74KSR10.49815413
75CAMK1G0.49423744
76MELK0.48503400
77PDGFRB0.44921695
78CAMK2A0.44840685
79MAP3K60.44116112
80PRKCH0.44072756
81CSNK1D0.44016171
82PTK2B0.43750828
83MINK10.43665182
84STK110.42657181
85EGFR0.38863781
86PRKCQ0.38057730
87RPS6KA40.37637830
88RET0.36970977
89ABL10.36907234
90* ATM0.36421997
91ERBB20.35692489
92ROCK10.35682664
93MAP3K50.34513117
94DYRK1A0.33301086
95MAP2K10.32983218
96CSF1R0.32615514
97PRKG10.32216080
98CSNK1G30.31957211
99IKBKE0.31952157
100MAPK70.31893768

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047102.34208365
2Dorso-ventral axis formation_Homo sapiens_hsa043202.19512967
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.87514006
4Nicotine addiction_Homo sapiens_hsa050331.64506270
5Inositol phosphate metabolism_Homo sapiens_hsa005621.58945635
6Phosphatidylinositol signaling system_Homo sapiens_hsa040701.58463723
7Renin secretion_Homo sapiens_hsa049241.47287318
8Circadian entrainment_Homo sapiens_hsa047131.47190002
9Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45175952
10FoxO signaling pathway_Homo sapiens_hsa040681.44612641
11Platelet activation_Homo sapiens_hsa046111.40380477
12Regulation of autophagy_Homo sapiens_hsa041401.32927962
13Endometrial cancer_Homo sapiens_hsa052131.28227919
14Dopaminergic synapse_Homo sapiens_hsa047281.26942342
15Glutamatergic synapse_Homo sapiens_hsa047241.26069137
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21568574
17Taste transduction_Homo sapiens_hsa047421.19442198
18Long-term depression_Homo sapiens_hsa047301.16387414
19Renal cell carcinoma_Homo sapiens_hsa052111.14210978
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14181050
21mTOR signaling pathway_Homo sapiens_hsa041501.12559420
22GABAergic synapse_Homo sapiens_hsa047271.12134337
23Protein export_Homo sapiens_hsa030601.11215408
24TGF-beta signaling pathway_Homo sapiens_hsa043501.09402550
25Prolactin signaling pathway_Homo sapiens_hsa049171.08878077
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08830326
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06599634
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05209013
29Melanoma_Homo sapiens_hsa052181.02324585
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01557759
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00856335
32Amphetamine addiction_Homo sapiens_hsa050310.99800504
33Alcoholism_Homo sapiens_hsa050340.97946533
34Fanconi anemia pathway_Homo sapiens_hsa034600.97884322
35ErbB signaling pathway_Homo sapiens_hsa040120.97120243
36Salivary secretion_Homo sapiens_hsa049700.96650110
37Morphine addiction_Homo sapiens_hsa050320.96012288
38Cholinergic synapse_Homo sapiens_hsa047250.95309516
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94953799
40Gap junction_Homo sapiens_hsa045400.93165786
41Adherens junction_Homo sapiens_hsa045200.91782336
42Colorectal cancer_Homo sapiens_hsa052100.90331024
43Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89631588
44Pancreatic cancer_Homo sapiens_hsa052120.88168496
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.87105514
46B cell receptor signaling pathway_Homo sapiens_hsa046620.86661622
47Gastric acid secretion_Homo sapiens_hsa049710.81321873
48Long-term potentiation_Homo sapiens_hsa047200.81315244
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79791001
50Thyroid hormone synthesis_Homo sapiens_hsa049180.77464519
51Oxytocin signaling pathway_Homo sapiens_hsa049210.77034109
52Measles_Homo sapiens_hsa051620.76594507
53cAMP signaling pathway_Homo sapiens_hsa040240.76342399
54Non-small cell lung cancer_Homo sapiens_hsa052230.76289332
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75781650
56Estrogen signaling pathway_Homo sapiens_hsa049150.75660907
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.75541805
58Prostate cancer_Homo sapiens_hsa052150.75053492
59Oocyte meiosis_Homo sapiens_hsa041140.73471025
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.72825003
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72650643
62Systemic lupus erythematosus_Homo sapiens_hsa053220.72642809
63Type II diabetes mellitus_Homo sapiens_hsa049300.72585835
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72059021
65Basal transcription factors_Homo sapiens_hsa030220.71169696
66Axon guidance_Homo sapiens_hsa043600.70767069
67ABC transporters_Homo sapiens_hsa020100.70458625
68Glioma_Homo sapiens_hsa052140.69587187
69Olfactory transduction_Homo sapiens_hsa047400.68861608
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67540784
71Non-homologous end-joining_Homo sapiens_hsa034500.67337963
72Cocaine addiction_Homo sapiens_hsa050300.66712982
73Focal adhesion_Homo sapiens_hsa045100.65958265
74Choline metabolism in cancer_Homo sapiens_hsa052310.65203828
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65203297
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.64864736
77Serotonergic synapse_Homo sapiens_hsa047260.64683587
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63895949
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.63331715
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62487456
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62413646
82T cell receptor signaling pathway_Homo sapiens_hsa046600.62374576
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61481254
84Rap1 signaling pathway_Homo sapiens_hsa040150.61401129
85Selenocompound metabolism_Homo sapiens_hsa004500.61244395
86Ras signaling pathway_Homo sapiens_hsa040140.61084640
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.60358243
88Pancreatic secretion_Homo sapiens_hsa049720.59002311
89MicroRNAs in cancer_Homo sapiens_hsa052060.58760658
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58140534
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.57755305
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55969448
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55152951
94Insulin secretion_Homo sapiens_hsa049110.54137783
95Insulin resistance_Homo sapiens_hsa049310.54137727
96Calcium signaling pathway_Homo sapiens_hsa040200.53830504
97Small cell lung cancer_Homo sapiens_hsa052220.53397505
98Viral carcinogenesis_Homo sapiens_hsa052030.53042535
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51730971
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.50520583

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