ZNF154

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the zinc finger Kruppel family of transcriptional regulators, whose members are thought to function in normal and abnormal cell growth and differentiation. Hypermethylation of this gene is associated with the recurrence of non muscle invasive bladder cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.07818848
2pyrimidine nucleobase catabolic process (GO:0006208)4.16364488
3L-fucose catabolic process (GO:0042355)4.04427487
4fucose catabolic process (GO:0019317)4.04427487
5L-fucose metabolic process (GO:0042354)4.04427487
6negative regulation of translation, ncRNA-mediated (GO:0040033)3.74618322
7regulation of translation, ncRNA-mediated (GO:0045974)3.74618322
8negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.74618322
9regulation of gene silencing by RNA (GO:0060966)3.62262531
10regulation of posttranscriptional gene silencing (GO:0060147)3.62262531
11regulation of gene silencing by miRNA (GO:0060964)3.62262531
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.45289916
13nucleobase catabolic process (GO:0046113)3.44231439
14negative regulation of cytosolic calcium ion concentration (GO:0051481)3.41020174
15kidney morphogenesis (GO:0060993)3.32247702
16neural tube formation (GO:0001841)3.30966354
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29164155
18negative regulation of telomere maintenance (GO:0032205)3.26828324
19presynaptic membrane assembly (GO:0097105)3.22740043
20positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.14698125
21gamma-aminobutyric acid transport (GO:0015812)3.09622948
22negative regulation of mast cell activation (GO:0033004)3.08084513
23indolalkylamine metabolic process (GO:0006586)3.00098106
24axoneme assembly (GO:0035082)2.98889300
25indole-containing compound catabolic process (GO:0042436)2.97506791
26indolalkylamine catabolic process (GO:0046218)2.97506791
27tryptophan catabolic process (GO:0006569)2.97506791
28protein K11-linked deubiquitination (GO:0035871)2.95221566
29atrial cardiac muscle cell action potential (GO:0086014)2.93137998
30detection of light stimulus involved in sensory perception (GO:0050962)2.92703114
31detection of light stimulus involved in visual perception (GO:0050908)2.92703114
32neuronal action potential (GO:0019228)2.89959039
33presynaptic membrane organization (GO:0097090)2.89934917
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87550196
35reflex (GO:0060004)2.86416790
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86136220
37nonmotile primary cilium assembly (GO:0035058)2.84981589
38epithelial cilium movement (GO:0003351)2.84834181
39DNA deamination (GO:0045006)2.82133870
40regulation of telomere maintenance (GO:0032204)2.80770419
41cilium morphogenesis (GO:0060271)2.79584572
42kynurenine metabolic process (GO:0070189)2.79065236
43DNA double-strand break processing (GO:0000729)2.77022682
44protein localization to cilium (GO:0061512)2.74250605
45photoreceptor cell maintenance (GO:0045494)2.74240057
46negative regulation of synaptic transmission, GABAergic (GO:0032229)2.68159446
47cornea development in camera-type eye (GO:0061303)2.67898276
48response to pheromone (GO:0019236)2.67394787
49cilium or flagellum-dependent cell motility (GO:0001539)2.67154176
50membrane depolarization during action potential (GO:0086010)2.65209566
51limb bud formation (GO:0060174)2.64921159
52establishment of protein localization to Golgi (GO:0072600)2.63306962
53rRNA catabolic process (GO:0016075)2.62295554
54piRNA metabolic process (GO:0034587)2.60375386
55cilium organization (GO:0044782)2.59781031
56regulation of hippo signaling (GO:0035330)2.59126757
57sulfation (GO:0051923)2.58893481
58postsynaptic membrane organization (GO:0001941)2.53303158
59cilium movement (GO:0003341)2.51039873
60tryptophan metabolic process (GO:0006568)2.50558789
61retinal cone cell development (GO:0046549)2.50514506
62cilium assembly (GO:0042384)2.49880282
63startle response (GO:0001964)2.48675388
64reciprocal DNA recombination (GO:0035825)2.47992622
65reciprocal meiotic recombination (GO:0007131)2.47992622
66auditory behavior (GO:0031223)2.46751776
67somite development (GO:0061053)2.46349724
68inositol phosphate catabolic process (GO:0071545)2.46284897
69protein polyglutamylation (GO:0018095)2.45360869
70water-soluble vitamin biosynthetic process (GO:0042364)2.44653503
71rhodopsin mediated signaling pathway (GO:0016056)2.44031948
72behavioral response to ethanol (GO:0048149)2.43906837
73ncRNA catabolic process (GO:0034661)2.43784223
74regulation of rhodopsin mediated signaling pathway (GO:0022400)2.43755703
75regulation of sarcomere organization (GO:0060297)2.43139858
76adaptation of signaling pathway (GO:0023058)2.42562916
77activated T cell proliferation (GO:0050798)2.42148511
78protein K63-linked deubiquitination (GO:0070536)2.39354434
79action potential (GO:0001508)2.38023839
80regulation of telomere maintenance via telomerase (GO:0032210)2.36359559
81neuronal action potential propagation (GO:0019227)2.36338848
82appendage development (GO:0048736)2.33294247
83limb development (GO:0060173)2.33294247
84neuron cell-cell adhesion (GO:0007158)2.32029152
85regulation of action potential (GO:0098900)2.32014431
86DNA demethylation (GO:0080111)2.31808331
87indole-containing compound metabolic process (GO:0042430)2.31158903
88transmission of nerve impulse (GO:0019226)2.28950778
89protein localization to synapse (GO:0035418)2.28162000
90spinal cord motor neuron differentiation (GO:0021522)2.28097863
91regulation of neurotransmitter uptake (GO:0051580)2.27572497
92cAMP catabolic process (GO:0006198)2.27558232
93DNA methylation involved in gamete generation (GO:0043046)2.26698213
94photoreceptor cell development (GO:0042461)2.26137208
95intraciliary transport (GO:0042073)2.25443311
96RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.24934279
97somatic diversification of immune receptors via somatic mutation (GO:0002566)2.24420096
98somatic hypermutation of immunoglobulin genes (GO:0016446)2.24420096
99glutamate receptor signaling pathway (GO:0007215)2.23822925
100regulation of mesoderm development (GO:2000380)2.23780533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.48634631
2ZNF274_21170338_ChIP-Seq_K562_Hela3.25139950
3EZH2_22144423_ChIP-Seq_EOC_Human3.07774977
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.83261826
5IGF1R_20145208_ChIP-Seq_DFB_Human2.79912162
6VDR_22108803_ChIP-Seq_LS180_Human2.75189873
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73739412
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.69357612
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54183696
10TAF15_26573619_Chip-Seq_HEK293_Human2.38170993
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27857491
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.22214729
13EWS_26573619_Chip-Seq_HEK293_Human2.19222152
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18673262
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18619260
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17480809
17FUS_26573619_Chip-Seq_HEK293_Human2.17091268
18P300_19829295_ChIP-Seq_ESCs_Human2.14448046
19ER_23166858_ChIP-Seq_MCF-7_Human1.97901810
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87575324
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.86490769
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79980755
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77593510
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73958035
25SMAD4_21799915_ChIP-Seq_A2780_Human1.73834818
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70569850
27STAT3_23295773_ChIP-Seq_U87_Human1.67457006
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61322214
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61322214
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59456988
31TCF4_23295773_ChIP-Seq_U87_Human1.58808444
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58101482
33BCAT_22108803_ChIP-Seq_LS180_Human1.56742884
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54826162
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.52414255
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50517428
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49033090
38CBP_20019798_ChIP-Seq_JUKART_Human1.49033090
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48685959
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.48017380
41IRF1_19129219_ChIP-ChIP_H3396_Human1.47377037
42AR_21572438_ChIP-Seq_LNCaP_Human1.46389954
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44535651
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.43959326
45AR_25329375_ChIP-Seq_VCAP_Human1.42651908
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38939115
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38561367
48REST_21632747_ChIP-Seq_MESCs_Mouse1.36675345
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34249346
50RUNX2_22187159_ChIP-Seq_PCA_Human1.32484360
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30810367
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.30561363
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30017379
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.28797287
55RNF2_27304074_Chip-Seq_NSC_Mouse1.28587324
56TCF4_22108803_ChIP-Seq_LS180_Human1.27121090
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25952189
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.25897477
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25259307
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24889686
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.23884047
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22355993
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21519647
64TP53_22573176_ChIP-Seq_HFKS_Human1.21486398
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20845782
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18014695
67SMAD4_21741376_ChIP-Seq_EPCs_Human1.17613635
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16695288
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16057809
70NANOG_19829295_ChIP-Seq_ESCs_Human1.15212255
71SOX2_19829295_ChIP-Seq_ESCs_Human1.15212255
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14310802
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14190752
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.13916012
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.11501086
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10425129
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09440779
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.08068077
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06264325
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06168907
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04595170
82TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03657041
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.02939898
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02939898
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.01827719
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01808169
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.01601322
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01388389
89P53_22387025_ChIP-Seq_ESCs_Mouse1.01212988
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01002360
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00056075
92KDM2B_26808549_Chip-Seq_REH_Human0.96570109
93CDX2_22108803_ChIP-Seq_LS180_Human0.96035727
94RXR_22108803_ChIP-Seq_LS180_Human0.95396724
95TP53_16413492_ChIP-PET_HCT116_Human0.95361931
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.93926815
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93767029
98DROSHA_22980978_ChIP-Seq_HELA_Human0.93647461
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92849479
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92733728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.96232343
2MP0002102_abnormal_ear_morphology2.79977737
3MP0000569_abnormal_digit_pigmentation2.65800493
4MP0001968_abnormal_touch/_nociception2.58793964
5MP0003787_abnormal_imprinting2.46511364
6MP0003880_abnormal_central_pattern2.46509685
7MP0005551_abnormal_eye_electrophysiolog2.31234714
8MP0003195_calcinosis2.25338463
9MP0002736_abnormal_nociception_after2.08724350
10MP0003646_muscle_fatigue2.06584135
11MP0005646_abnormal_pituitary_gland2.04895503
12MP0006276_abnormal_autonomic_nervous2.01421126
13MP0006072_abnormal_retinal_apoptosis1.99986593
14MP0009745_abnormal_behavioral_response1.92086328
15MP0002837_dystrophic_cardiac_calcinosis1.91933306
16MP0002638_abnormal_pupillary_reflex1.90121752
17MP0001486_abnormal_startle_reflex1.87256541
18MP0005253_abnormal_eye_physiology1.83713235
19MP0004885_abnormal_endolymph1.83036669
20MP0009046_muscle_twitch1.81431242
21MP0003890_abnormal_embryonic-extraembry1.80301482
22MP0001986_abnormal_taste_sensitivity1.70825070
23MP0001501_abnormal_sleep_pattern1.69701279
24MP0002272_abnormal_nervous_system1.69018878
25MP0006292_abnormal_olfactory_placode1.65472205
26MP0002653_abnormal_ependyma_morphology1.63908735
27MP0004142_abnormal_muscle_tone1.60591870
28MP0005174_abnormal_tail_pigmentation1.59388884
29MP0003136_yellow_coat_color1.59086227
30MP0001984_abnormal_olfaction1.58502581
31MP0005423_abnormal_somatic_nervous1.54282178
32MP0003635_abnormal_synaptic_transmissio1.49436385
33MP0004145_abnormal_muscle_electrophysio1.49024363
34MP0001188_hyperpigmentation1.47172588
35MP0004043_abnormal_pH_regulation1.43404346
36MP0002735_abnormal_chemical_nociception1.41213539
37MP0002572_abnormal_emotion/affect_behav1.40820257
38MP0001485_abnormal_pinna_reflex1.40115463
39MP0003011_delayed_dark_adaptation1.39924152
40MP0005075_abnormal_melanosome_morpholog1.39261343
41MP0002064_seizures1.39240700
42MP0008872_abnormal_physiological_respon1.38320754
43MP0000631_abnormal_neuroendocrine_gland1.37880036
44MP0005645_abnormal_hypothalamus_physiol1.35083358
45MP0004742_abnormal_vestibular_system1.30509751
46MP0002557_abnormal_social/conspecific_i1.30218789
47MP0002063_abnormal_learning/memory/cond1.28303003
48MP0002067_abnormal_sensory_capabilities1.27603992
49MP0003121_genomic_imprinting1.26003283
50MP0000372_irregular_coat_pigmentation1.24861614
51MP0001529_abnormal_vocalization1.24732466
52MP0000778_abnormal_nervous_system1.24510563
53MP0002938_white_spotting1.24082598
54MP0000427_abnormal_hair_cycle1.17897684
55MP0004147_increased_porphyrin_level1.16167831
56MP0005499_abnormal_olfactory_system1.16006644
57MP0005394_taste/olfaction_phenotype1.16006644
58MP0005386_behavior/neurological_phenoty1.15901690
59MP0004924_abnormal_behavior1.15901690
60MP0003137_abnormal_impulse_conducting1.14605493
61MP0004859_abnormal_synaptic_plasticity1.13307901
62MP0004133_heterotaxia1.13280996
63MP0002751_abnormal_autonomic_nervous1.12246517
64MP0002876_abnormal_thyroid_physiology1.10872582
65MP0001177_atelectasis1.10266733
66MP0004215_abnormal_myocardial_fiber1.09128771
67MP0001970_abnormal_pain_threshold1.08031823
68MP0002733_abnormal_thermal_nociception1.02764280
69MP0002734_abnormal_mechanical_nocicepti1.01185468
70MP0008057_abnormal_DNA_replication1.00872356
71MP0002184_abnormal_innervation0.99983035
72MP0002138_abnormal_hepatobiliary_system0.99406319
73MP0002752_abnormal_somatic_nervous0.98699184
74MP0005377_hearing/vestibular/ear_phenot0.97990030
75MP0003878_abnormal_ear_physiology0.97990030
76MP0008789_abnormal_olfactory_epithelium0.97437328
77MP0003937_abnormal_limbs/digits/tail_de0.94349448
78MP0004084_abnormal_cardiac_muscle0.93969546
79MP0001293_anophthalmia0.93097624
80MP0000383_abnormal_hair_follicle0.92782933
81MP0004085_abnormal_heartbeat0.90927980
82MP0010386_abnormal_urinary_bladder0.90475240
83MP0002095_abnormal_skin_pigmentation0.89083516
84MP0003119_abnormal_digestive_system0.88244721
85MP0005195_abnormal_posterior_eye0.88184939
86MP0000049_abnormal_middle_ear0.86393874
87MP0001440_abnormal_grooming_behavior0.86179183
88MP0005391_vision/eye_phenotype0.85741514
89MP0001963_abnormal_hearing_physiology0.85495821
90MP0001502_abnormal_circadian_rhythm0.85051881
91MP0003122_maternal_imprinting0.82602522
92MP0002160_abnormal_reproductive_system0.82519250
93MP0004484_altered_response_of0.81602043
94MP0005389_reproductive_system_phenotype0.81151267
95MP0002882_abnormal_neuron_morphology0.80323625
96MP0000026_abnormal_inner_ear0.78195699
97MP0002822_catalepsy0.77756058
98MP0008995_early_reproductive_senescence0.77577132
99MP0000955_abnormal_spinal_cord0.76235519
100MP0004130_abnormal_muscle_cell0.76086928

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.07261073
2Molar tooth sign on MRI (HP:0002419)3.77308107
3Abnormality of midbrain morphology (HP:0002418)3.77308107
4Hyperventilation (HP:0002883)3.74705084
5Pancreatic fibrosis (HP:0100732)3.58167031
6Chronic hepatic failure (HP:0100626)3.38748450
7True hermaphroditism (HP:0010459)3.38498110
8Nephronophthisis (HP:0000090)3.26387954
9Attenuation of retinal blood vessels (HP:0007843)3.08762013
10Type II lissencephaly (HP:0007260)3.05763344
11Congenital stationary night blindness (HP:0007642)3.04734664
12Gaze-evoked nystagmus (HP:0000640)3.02081571
13Progressive cerebellar ataxia (HP:0002073)3.01650705
14Abnormality of the renal cortex (HP:0011035)2.98933516
15Inability to walk (HP:0002540)2.95529928
16Protruding tongue (HP:0010808)2.94959052
17Abnormality of the renal medulla (HP:0100957)2.92497186
18Broad-based gait (HP:0002136)2.89674260
19Stomach cancer (HP:0012126)2.87218736
20Medial flaring of the eyebrow (HP:0010747)2.83656829
21Genetic anticipation (HP:0003743)2.78917823
22Febrile seizures (HP:0002373)2.56679120
23Abnormality of the labia minora (HP:0012880)2.52994618
24Cystic liver disease (HP:0006706)2.52904239
25Progressive inability to walk (HP:0002505)2.49450748
26Aplasia/Hypoplasia of the tibia (HP:0005772)2.48675862
27Clumsiness (HP:0002312)2.45307105
28Gait imbalance (HP:0002141)2.43118985
29Abolished electroretinogram (ERG) (HP:0000550)2.39389829
30Intestinal atresia (HP:0011100)2.39049793
31Congenital primary aphakia (HP:0007707)2.33929314
32Absent speech (HP:0001344)2.32077251
33Lissencephaly (HP:0001339)2.31664032
34Genital tract atresia (HP:0001827)2.29913067
35Renal cortical cysts (HP:0000803)2.29107486
36Bile duct proliferation (HP:0001408)2.25653782
37Abnormal biliary tract physiology (HP:0012439)2.25653782
38Focal motor seizures (HP:0011153)2.23210074
39Vaginal atresia (HP:0000148)2.23044141
40Tubular atrophy (HP:0000092)2.18820531
41Retinal dysplasia (HP:0007973)2.18526012
42Large for gestational age (HP:0001520)2.15062613
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14807617
44Focal seizures (HP:0007359)2.14201296
45Thyroiditis (HP:0100646)2.13894295
46Pachygyria (HP:0001302)2.13426623
47Polydipsia (HP:0001959)2.13143970
48Abnormal drinking behavior (HP:0030082)2.13143970
49Nephrogenic diabetes insipidus (HP:0009806)2.12725815
50Anencephaly (HP:0002323)2.11018810
51Abnormal rod and cone electroretinograms (HP:0008323)2.10841750
52Abnormality of eosinophils (HP:0001879)2.10728048
53Absent/shortened dynein arms (HP:0200106)2.10127174
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.10127174
55Cerebellar dysplasia (HP:0007033)2.06687077
56Stomatitis (HP:0010280)2.06494626
57Drooling (HP:0002307)2.05644632
58Colon cancer (HP:0003003)2.04010123
59Thyroid-stimulating hormone excess (HP:0002925)2.01550530
60Atonic seizures (HP:0010819)2.00768131
61Sclerocornea (HP:0000647)1.96357998
62Hemiparesis (HP:0001269)1.93179268
63IgG deficiency (HP:0004315)1.92286580
64Decreased central vision (HP:0007663)1.91998641
65Methylmalonic acidemia (HP:0002912)1.91196555
66Optic nerve hypoplasia (HP:0000609)1.90586966
67Bony spicule pigmentary retinopathy (HP:0007737)1.89077993
68Excessive salivation (HP:0003781)1.88243884
69Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87494826
70Keratoconus (HP:0000563)1.86285678
71Increased corneal curvature (HP:0100692)1.86285678
72Pendular nystagmus (HP:0012043)1.85825287
73Postaxial hand polydactyly (HP:0001162)1.85252363
74Volvulus (HP:0002580)1.85232830
75Fair hair (HP:0002286)1.84853352
76Short tibia (HP:0005736)1.82613946
77Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82174204
78Hypothermia (HP:0002045)1.80247058
79Cupped ear (HP:0000378)1.79287288
80Congenital hepatic fibrosis (HP:0002612)1.78612930
81Dialeptic seizures (HP:0011146)1.78356330
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.78202115
83Poor coordination (HP:0002370)1.77652696
84Postaxial foot polydactyly (HP:0001830)1.77500123
85Patellar aplasia (HP:0006443)1.76412394
86Widely spaced teeth (HP:0000687)1.76164780
87Polyuria (HP:0000103)1.75035469
88Dyskinesia (HP:0100660)1.74084748
89Abnormality of macular pigmentation (HP:0008002)1.72360825
90Small hand (HP:0200055)1.72015600
91Decreased circulating renin level (HP:0003351)1.70822673
92Constricted visual fields (HP:0001133)1.70767244
93Narrow forehead (HP:0000341)1.69609920
94Hypoplastic iliac wings (HP:0002866)1.66932029
95Male pseudohermaphroditism (HP:0000037)1.66159941
96Aplasia/Hypoplasia of the patella (HP:0006498)1.65967074
97Short foot (HP:0001773)1.65686893
98Preaxial hand polydactyly (HP:0001177)1.61808051
99Dandy-Walker malformation (HP:0001305)1.61228746
100Abnormality of the phalanges of the 2nd finger (HP:0009541)1.58845749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.14810273
2TAOK33.69690048
3BMPR1B2.74852979
4MAP4K22.63658875
5CASK2.58394794
6WNK32.39364649
7ADRBK22.29124830
8TLK12.14540837
9PINK12.11481285
10NUAK12.05818542
11ACVR1B2.05774058
12ZAK2.02596827
13MAP3K41.75315429
14GRK11.73725791
15MKNK21.72398022
16MAPK131.60986476
17FGFR21.60528678
18INSRR1.52854042
19TNIK1.52403839
20TXK1.41321157
21MARK11.36170482
22DAPK21.31550239
23WNK41.30560797
24DYRK21.29422347
25NLK1.28763759
26OBSCN1.28254408
27PAK31.26967565
28SGK21.21944049
29CSNK1A1L1.21625704
30MAP2K71.21624133
31CSNK1G21.20343212
32CSNK1G11.18163385
33TIE11.11456317
34CSNK1G31.10191563
35EPHA41.08584204
36STK38L1.08388224
37OXSR11.06760316
38TEC1.06314156
39MKNK11.03853547
40KIT1.02465022
41TNK21.00979672
42TGFBR10.99534268
43SGK2230.97495080
44SGK4940.97495080
45AKT30.97395570
46BCR0.93299589
47EPHA30.93212757
48NTRK20.89916759
49MARK30.89434048
50TRIM280.87134542
51ADRBK10.81904615
52STK390.81250194
53PRKCE0.81160361
54NTRK30.74945092
55PIK3CA0.73167507
56LATS10.71477904
57PRKCG0.69573183
58MAP4K10.68238603
59STK110.66328528
60CAMKK20.63241722
61BRSK20.61753718
62PKN10.61537113
63CDK30.61502501
64PLK20.61355921
65PIK3CG0.60817530
66PRKCQ0.58856640
67CSNK1D0.56533355
68VRK10.56513679
69SYK0.56409548
70BTK0.54184062
71CAMK10.52609117
72FES0.51904875
73PLK40.51568085
74DYRK30.51556516
75RPS6KA50.51400857
76PNCK0.50611893
77ERBB30.49841052
78IRAK10.49821620
79CSNK1A10.49818498
80NEK20.47802722
81CAMK2A0.47738602
82DYRK1A0.46724769
83PTK2B0.46235195
84STK30.45167082
85BCKDK0.44199996
86BRD40.44164179
87SIK20.43915699
88PRKACA0.41461535
89CAMK40.40325543
90ITK0.40017409
91MUSK0.39421065
92SGK30.37356959
93PRKG10.34272086
94IKBKB0.33901544
95MAP3K70.32922095
96CDK50.32862970
97CDK190.31889240
98PHKG10.30344369
99PHKG20.30344369
100RPS6KA40.30094178

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.82449332
2Nicotine addiction_Homo sapiens_hsa050332.82545173
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.65042655
4Linoleic acid metabolism_Homo sapiens_hsa005912.61900847
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.58348795
6Nitrogen metabolism_Homo sapiens_hsa009102.57545846
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.54558824
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.48483198
9Ether lipid metabolism_Homo sapiens_hsa005652.28440196
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.07619970
11Olfactory transduction_Homo sapiens_hsa047402.04298608
12Taste transduction_Homo sapiens_hsa047421.88447467
13Butanoate metabolism_Homo sapiens_hsa006501.77950167
14Caffeine metabolism_Homo sapiens_hsa002321.73259868
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71405748
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62073982
17Circadian entrainment_Homo sapiens_hsa047131.58669525
18Morphine addiction_Homo sapiens_hsa050321.57082712
19Primary immunodeficiency_Homo sapiens_hsa053401.56682919
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46158605
21Tryptophan metabolism_Homo sapiens_hsa003801.43283868
22Glutamatergic synapse_Homo sapiens_hsa047241.41314946
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39670317
24GABAergic synapse_Homo sapiens_hsa047271.38159656
25Selenocompound metabolism_Homo sapiens_hsa004501.37630697
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.35725328
27Basal transcription factors_Homo sapiens_hsa030221.33626529
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30594599
29Serotonergic synapse_Homo sapiens_hsa047261.24320104
30Fanconi anemia pathway_Homo sapiens_hsa034601.23902742
31Homologous recombination_Homo sapiens_hsa034401.22874308
32ABC transporters_Homo sapiens_hsa020101.22784722
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20360035
34Insulin secretion_Homo sapiens_hsa049111.18402914
35Dorso-ventral axis formation_Homo sapiens_hsa043201.17421640
36RNA degradation_Homo sapiens_hsa030181.15245159
37Regulation of autophagy_Homo sapiens_hsa041401.13141015
38Arachidonic acid metabolism_Homo sapiens_hsa005901.10749274
39Calcium signaling pathway_Homo sapiens_hsa040201.08765225
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.08729920
41Salivary secretion_Homo sapiens_hsa049701.04817230
42Circadian rhythm_Homo sapiens_hsa047101.01380559
43RNA polymerase_Homo sapiens_hsa030201.01004824
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00734663
45Propanoate metabolism_Homo sapiens_hsa006401.00441406
46Dopaminergic synapse_Homo sapiens_hsa047280.96965406
47Long-term depression_Homo sapiens_hsa047300.95490371
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.94796747
49Amphetamine addiction_Homo sapiens_hsa050310.89532715
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.86378458
51Renin secretion_Homo sapiens_hsa049240.85496809
52Ovarian steroidogenesis_Homo sapiens_hsa049130.82259090
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81507480
54Oxytocin signaling pathway_Homo sapiens_hsa049210.80360086
55Asthma_Homo sapiens_hsa053100.78816317
56Glycerolipid metabolism_Homo sapiens_hsa005610.74922510
57Cholinergic synapse_Homo sapiens_hsa047250.74028037
58Gastric acid secretion_Homo sapiens_hsa049710.72037632
59cAMP signaling pathway_Homo sapiens_hsa040240.71604471
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70606731
61Cardiac muscle contraction_Homo sapiens_hsa042600.69948842
62Hedgehog signaling pathway_Homo sapiens_hsa043400.69259535
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68571121
64Retinol metabolism_Homo sapiens_hsa008300.68192997
65beta-Alanine metabolism_Homo sapiens_hsa004100.66950911
66Protein export_Homo sapiens_hsa030600.66752648
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65350054
68Chemical carcinogenesis_Homo sapiens_hsa052040.65327065
69Non-homologous end-joining_Homo sapiens_hsa034500.65223056
70Peroxisome_Homo sapiens_hsa041460.64724201
71Cocaine addiction_Homo sapiens_hsa050300.63336559
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.62376850
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61004739
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59910550
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58999388
76Vitamin digestion and absorption_Homo sapiens_hsa049770.58231360
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57956283
78Oxidative phosphorylation_Homo sapiens_hsa001900.57030850
79Type I diabetes mellitus_Homo sapiens_hsa049400.56812830
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.56209729
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54799304
82Lysine degradation_Homo sapiens_hsa003100.53137767
83One carbon pool by folate_Homo sapiens_hsa006700.51252494
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49535234
85Basal cell carcinoma_Homo sapiens_hsa052170.46854659
86Graft-versus-host disease_Homo sapiens_hsa053320.46471615
87Autoimmune thyroid disease_Homo sapiens_hsa053200.45343863
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45166723
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44393965
90Axon guidance_Homo sapiens_hsa043600.43185309
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42127111
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40130389
93Ras signaling pathway_Homo sapiens_hsa040140.40100473
94Allograft rejection_Homo sapiens_hsa053300.38523823
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37269330
96Histidine metabolism_Homo sapiens_hsa003400.36537722
97Steroid biosynthesis_Homo sapiens_hsa001000.34132609
98Type II diabetes mellitus_Homo sapiens_hsa049300.32281619
99Purine metabolism_Homo sapiens_hsa002300.31423409
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31401086

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