ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of DNA methylation (GO:0044030)	9.32169739
2	regulation of female gonad development (GO:2000194)	8.79544602
3	piRNA metabolic process (GO:0034587)	8.46645848
4	regulation of acrosome reaction (GO:0060046)	8.02706990
5	meiotic cell cycle (GO:0051321)	7.56813360
6	retinal cone cell development (GO:0046549)	7.34965315
7	regulation of meiosis I (GO:0060631)	7.11067051
8	positive regulation of histone H3-K4 methylation (GO:0051571)	6.30001759
9	regulation of histone H3-K9 methylation (GO:0051570)	6.09267127
10	DNA methylation involved in gamete generation (GO:0043046)	5.96288787
11	multicellular organism reproduction (GO:0032504)	5.94760012
12	oocyte development (GO:0048599)	5.84657133
13	female gamete generation (GO:0007292)	5.57781389
14	regulation of cell maturation (GO:1903429)	5.38413618
15	gene silencing by RNA (GO:0031047)	5.14133570
16	negative regulation of reproductive process (GO:2000242)	4.93916330
17	centriole replication (GO:0007099)	4.87934060
18	negative regulation of histone methylation (GO:0031061)	4.79043501
19	positive regulation of humoral immune response (GO:0002922)	4.75099335
20	regulation of steroid hormone secretion (GO:2000831)	4.67942345
21	DNA replication-dependent nucleosome organization (GO:0034723)	4.51601551
22	DNA replication-dependent nucleosome assembly (GO:0006335)	4.51601551
23	protein kinase C signaling (GO:0070528)	4.37249706
24	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.29861468
25	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.20939919
26	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.20939919
27	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.20939919
28	protein localization to kinetochore (GO:0034501)	4.16275823
29	glycine transport (GO:0015816)	4.12225072
30	protein localization to chromosome, centromeric region (GO:0071459)	3.97065918
31	synapsis (GO:0007129)	3.91454544
32	positive regulation of histone methylation (GO:0031062)	3.89236269
33	positive regulation of gastrulation (GO:2000543)	3.86067032
34	interkinetic nuclear migration (GO:0022027)	3.83552047
35	attachment of spindle microtubules to kinetochore (GO:0008608)	3.76921010
36	reproduction (GO:0000003)	3.75971808
37	protein localization to chromosome (GO:0034502)	3.69974068
38	establishment of chromosome localization (GO:0051303)	3.66243814
39	regulation of histone H3-K4 methylation (GO:0051569)	3.60806036
40	mitotic metaphase plate congression (GO:0007080)	3.60110655
41	regulation of spindle organization (GO:0090224)	3.59501345
42	mitotic chromosome condensation (GO:0007076)	3.56110849
43	N-terminal protein amino acid acetylation (GO:0006474)	3.55387615
44	regulation of meiosis (GO:0040020)	3.52456801
45	positive regulation of reproductive process (GO:2000243)	3.48870827
46	translesion synthesis (GO:0019985)	3.48108958
47	primitive streak formation (GO:0090009)	3.47697963
48	male meiosis (GO:0007140)	3.43791433
49	binding of sperm to zona pellucida (GO:0007339)	3.40886518
50	fertilization (GO:0009566)	3.40177661
51	positive regulation of chromosome segregation (GO:0051984)	3.36238707
52	regulation of chromatin silencing (GO:0031935)	3.34671750
53	gene silencing (GO:0016458)	3.34156100
54	metaphase plate congression (GO:0051310)	3.33028272
55	centriole assembly (GO:0098534)	3.25743572
56	regulation of steroid hormone biosynthetic process (GO:0090030)	3.24720728
57	DNA methylation (GO:0006306)	3.22093705
58	DNA alkylation (GO:0006305)	3.22093705
59	cullin deneddylation (GO:0010388)	3.21715874
60	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	3.20348575
61	CENP-A containing nucleosome assembly (GO:0034080)	3.17368486
62	phosphorelay signal transduction system (GO:0000160)	3.16958936
63	neuron fate determination (GO:0048664)	3.16954722
64	somite rostral/caudal axis specification (GO:0032525)	3.16446011
65	protein deneddylation (GO:0000338)	3.15381439
66	stress granule assembly (GO:0034063)	3.13941823
67	regulation of histone methylation (GO:0031060)	3.13705225
68	negative regulation of execution phase of apoptosis (GO:1900118)	3.13583403
69	oogenesis (GO:0048477)	3.10239410
70	aggressive behavior (GO:0002118)	3.09674961
71	single fertilization (GO:0007338)	3.07455644
72	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.04618373
73	L-amino acid import (GO:0043092)	3.02504846
74	regulation of reproductive process (GO:2000241)	2.98570835
75	postreplication repair (GO:0006301)	2.97733112
76	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.95916847
77	regulation of meiotic cell cycle (GO:0051445)	2.95790978
78	base-excision repair, AP site formation (GO:0006285)	2.95699600
79	negative regulation of histone modification (GO:0031057)	2.95509609
80	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.95338300
81	hyperosmotic salinity response (GO:0042538)	2.91310730
82	chromatin remodeling at centromere (GO:0031055)	2.90716284
83	male meiosis I (GO:0007141)	2.90331569
84	chromosome organization involved in meiosis (GO:0070192)	2.87603030
85	pyrimidine dimer repair (GO:0006290)	2.87523311
86	synaptonemal complex assembly (GO:0007130)	2.83513863
87	meiotic cell cycle process (GO:1903046)	2.77900936
88	meiotic nuclear division (GO:0007126)	2.77760020
89	DNA replication-independent nucleosome assembly (GO:0006336)	2.77322302
90	DNA replication-independent nucleosome organization (GO:0034724)	2.77322302
91	mitotic G2/M transition checkpoint (GO:0044818)	2.76757820
92	androgen receptor signaling pathway (GO:0030521)	2.75656684
93	sister chromatid cohesion (GO:0007062)	2.71853576
94	sperm-egg recognition (GO:0035036)	2.69380299
95	regulation of spindle checkpoint (GO:0090231)	2.68264314
96	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.67784767
97	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.64887187
98	negative regulation of chromatin modification (GO:1903309)	2.64841230
99	positive regulation of meiosis (GO:0045836)	2.64717274
100	histone exchange (GO:0043486)	2.64637611

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.28841705
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.20359668
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.45204269
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.93153624
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.90570989
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.68067380
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.55771616
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.32834991
9	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.17854460
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.17237699
11	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.13563870
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.07729640
13	E2F7_22180533_ChIP-Seq_HELA_Human	2.01468302
14	EZH2_22144423_ChIP-Seq_EOC_Human	10.2374134
15	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.97288805
16	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.97288805
17	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.97288805
18	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.87551471
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.84511156
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.81532295
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.78603365
22	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.78288428
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.70683535
24	VDR_22108803_ChIP-Seq_LS180_Human	1.70249596
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.59864741
26	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.58601073
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56560658
28	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.52879074
29	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.52056974
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47685794
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.47685794
32	P300_19829295_ChIP-Seq_ESCs_Human	1.45612005
33	EWS_26573619_Chip-Seq_HEK293_Human	1.45284368
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.42231944
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.40308010
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.37890976
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36924466
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36244171
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34710661
40	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.33538738
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.33265873
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33258141
43	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.32018046
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.31520714
45	TCF4_23295773_ChIP-Seq_U87_Human	1.31120421
46	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31059054
47	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.28364248
48	* CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.28084300
49	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.26598490
50	AR_25329375_ChIP-Seq_VCAP_Human	1.24990622
51	FUS_26573619_Chip-Seq_HEK293_Human	1.24951589
52	STAT3_23295773_ChIP-Seq_U87_Human	1.22434645
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21130688
54	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.19257260
55	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.18982996
56	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.18539764
57	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18249162
58	ELK1_19687146_ChIP-ChIP_HELA_Human	1.16822507
59	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.15865362
60	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.13872812
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12606211
62	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11757166
63	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.11534846
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11407349
65	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.11224421
66	ER_23166858_ChIP-Seq_MCF-7_Human	1.09611699
67	* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.08257887
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07868956
69	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.07717687
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.07318230
71	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.06701904
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05038282
73	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.00476510
74	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.98903513
75	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98653154
76	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.97442529
77	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97185798
78	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96530427
79	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.95633519
80	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95633519
81	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.93028572
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92276724
83	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.91960448
84	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.91764202
85	TFEB_21752829_ChIP-Seq_HELA_Human	0.89171188
86	SMRT_27268052_Chip-Seq_Bcells_Human	0.88444134
87	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.87502853
88	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.86704209
89	HTT_18923047_ChIP-ChIP_STHdh_Human	0.86372460
90	SOX2_19829295_ChIP-Seq_ESCs_Human	0.86266311
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.86266311
92	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.86183892
93	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.84097849
94	AR_21909140_ChIP-Seq_LNCAP_Human	0.83196327
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.82564033
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.82127532
97	RNF2_27304074_Chip-Seq_NSC_Mouse	0.80927535
98	* NANOG_20526341_ChIP-Seq_ESCs_Human	0.80781024
99	TP53_22573176_ChIP-Seq_HFKS_Human	0.80542535
100	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.80339503

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	8.21520341
2	MP0006292_abnormal_olfactory_placode	4.78143844
3	MP0008877_abnormal_DNA_methylation	4.52781671
4	MP0008789_abnormal_olfactory_epithelium	4.06377572
5	MP0008057_abnormal_DNA_replication	3.68816173
6	MP0005499_abnormal_olfactory_system	3.55286668
7	MP0005394_taste/olfaction_phenotype	3.55286668
8	MP0005395_other_phenotype	3.48051491
9	MP0008058_abnormal_DNA_repair	2.99370825
10	MP0003890_abnormal_embryonic-extraembry	2.61667683
11	MP0003880_abnormal_central_pattern	2.58478074
12	MP0003693_abnormal_embryo_hatching	2.52182428
13	MP0002138_abnormal_hepatobiliary_system	2.45511795
14	MP0003699_abnormal_female_reproductive	2.30312857
15	MP0002139_abnormal_hepatobiliary_system	2.20306757
16	MP0001929_abnormal_gametogenesis	2.16873033
17	MP0003077_abnormal_cell_cycle	2.15677060
18	MP0002234_abnormal_pharynx_morphology	2.10753391
19	MP0002210_abnormal_sex_determination	1.97990990
20	MP0010094_abnormal_chromosome_stability	1.93788423
21	MP0010307_abnormal_tumor_latency	1.80808924
22	MP0003252_abnormal_bile_duct	1.70609123
23	MP0002751_abnormal_autonomic_nervous	1.68571000
24	MP0000653_abnormal_sex_gland	1.68260704
25	MP0002102_abnormal_ear_morphology	1.68011440
26	MP0005646_abnormal_pituitary_gland	1.59869478
27	MP0000631_abnormal_neuroendocrine_gland	1.59642273
28	MP0003111_abnormal_nucleus_morphology	1.56743288
29	MP0002233_abnormal_nose_morphology	1.53663127
30	MP0001119_abnormal_female_reproductive	1.49572908
31	MP0002161_abnormal_fertility/fecundity	1.45402127
32	MP0008932_abnormal_embryonic_tissue	1.43679101
33	MP0003183_abnormal_peptide_metabolism	1.38411276
34	MP0001984_abnormal_olfaction	1.35320061
35	MP0001145_abnormal_male_reproductive	1.34370258
36	MP0003121_genomic_imprinting	1.31531247
37	MP0001293_anophthalmia	1.28048095
38	MP0010234_abnormal_vibrissa_follicle	1.24569973
39	MP0000762_abnormal_tongue_morphology	1.17148970
40	MP0010030_abnormal_orbit_morphology	1.13283023
41	MP0005075_abnormal_melanosome_morpholog	1.10759005
42	MP0002928_abnormal_bile_duct	1.07344008
43	MP0005410_abnormal_fertilization	1.06782746
44	MP0003698_abnormal_male_reproductive	1.05823173
45	MP0002396_abnormal_hematopoietic_system	1.02045795
46	MP0005423_abnormal_somatic_nervous	1.01611187
47	MP0001730_embryonic_growth_arrest	1.00411080
48	MP0003950_abnormal_plasma_membrane	0.99661357
49	MP0003119_abnormal_digestive_system	0.99331078
50	MP0002160_abnormal_reproductive_system	0.97773843
51	MP0000566_synostosis	0.95722075
52	MP0000427_abnormal_hair_cycle	0.90443685
53	MP0005360_urolithiasis	0.89988938
54	MP0003656_abnormal_erythrocyte_physiolo	0.89667346
55	MP0005085_abnormal_gallbladder_physiolo	0.86206669
56	MP0009840_abnormal_foam_cell	0.85922861
57	MP0004142_abnormal_muscle_tone	0.83792932
58	MP0001672_abnormal_embryogenesis/_devel	0.83448007
59	MP0005380_embryogenesis_phenotype	0.83448007
60	MP0005551_abnormal_eye_electrophysiolog	0.81184370
61	MP0001324_abnormal_eye_pigmentation	0.80945955
62	MP0005647_abnormal_sex_gland	0.80797240
63	MP0008995_early_reproductive_senescence	0.78220255
64	MP0006276_abnormal_autonomic_nervous	0.76671750
65	MP0005389_reproductive_system_phenotype	0.74405416
66	MP0000350_abnormal_cell_proliferation	0.73930698
67	MP0003879_abnormal_hair_cell	0.72122495
68	MP0000613_abnormal_salivary_gland	0.70880827
69	MP0003755_abnormal_palate_morphology	0.69660143
70	MP0002090_abnormal_vision	0.68599190
71	MP0003935_abnormal_craniofacial_develop	0.67471732
72	MP0005253_abnormal_eye_physiology	0.64504491
73	MP0000049_abnormal_middle_ear	0.64386763
74	MP0000569_abnormal_digit_pigmentation	0.63136818
75	MP0000647_abnormal_sebaceous_gland	0.60731863
76	MP0000516_abnormal_urinary_system	0.59992442
77	MP0005367_renal/urinary_system_phenotyp	0.59992442
78	MP0001986_abnormal_taste_sensitivity	0.59914349
79	MP0004043_abnormal_pH_regulation	0.59700413
80	MP0006072_abnormal_retinal_apoptosis	0.57876332
81	MP0002095_abnormal_skin_pigmentation	0.57197932
82	MP0010678_abnormal_skin_adnexa	0.57109383
83	MP0005174_abnormal_tail_pigmentation	0.56295529
84	MP0002019_abnormal_tumor_incidence	0.53904942
85	MP0003221_abnormal_cardiomyocyte_apopto	0.53821907
86	MP0003786_premature_aging	0.52373020
87	MP0006035_abnormal_mitochondrial_morpho	0.50598175
88	MP0000377_abnormal_hair_follicle	0.50270454
89	MP0001664_abnormal_digestion	0.49566497
90	MP0002084_abnormal_developmental_patter	0.49303763
91	MP0006054_spinal_hemorrhage	0.48890102
92	MP0001188_hyperpigmentation	0.48517838
93	MP0001529_abnormal_vocalization	0.47869383
94	MP0002127_abnormal_cardiovascular_syste	0.45967355
95	MP0000465_gastrointestinal_hemorrhage	0.45755696
96	MP0005187_abnormal_penis_morphology	0.43785394
97	MP0000313_abnormal_cell_death	0.42131289
98	MP0010368_abnormal_lymphatic_system	0.41131613
99	MP0002272_abnormal_nervous_system	0.40345133
100	MP0004957_abnormal_blastocyst_morpholog	0.40295700

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Supernumerary spleens (HP:0009799)	4.83863962
2	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.43758477
3	Papillary thyroid carcinoma (HP:0002895)	4.32660037
4	Anterior segment dysgenesis (HP:0007700)	4.30969755
5	Facial hemangioma (HP:0000329)	3.99922258
6	Median cleft lip (HP:0000161)	3.92616868
7	Oligodactyly (hands) (HP:0001180)	3.74035704
8	Abnormality of abdominal situs (HP:0011620)	3.70041665
9	Abdominal situs inversus (HP:0003363)	3.70041665
10	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.66972308
11	Hypoplasia of the fovea (HP:0007750)	3.66972308
12	Lip pit (HP:0100267)	3.60894159
13	Apathy (HP:0000741)	3.56345261
14	Cholecystitis (HP:0001082)	3.54247114
15	Abnormal gallbladder physiology (HP:0012438)	3.54247114
16	Septo-optic dysplasia (HP:0100842)	3.47822385
17	Abnormality of the fovea (HP:0000493)	3.46204554
18	Diminished motivation (HP:0000745)	3.36668357
19	Impulsivity (HP:0100710)	3.31785603
20	Short tibia (HP:0005736)	3.20625549
21	Osteomalacia (HP:0002749)	3.19984108
22	Chromsome breakage (HP:0040012)	3.03065769
23	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.95854105
24	Abnormality of the labia minora (HP:0012880)	2.95023112
25	Gonadotropin excess (HP:0000837)	2.94228255
26	Male infertility (HP:0003251)	2.94004377
27	Abnormal biliary tract physiology (HP:0012439)	2.88671859
28	Bile duct proliferation (HP:0001408)	2.88671859
29	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.82541204
30	Thyroid carcinoma (HP:0002890)	2.79810944
31	Capillary hemangiomas (HP:0005306)	2.78215655
32	Hypophosphatemic rickets (HP:0004912)	2.75040933
33	Molar tooth sign on MRI (HP:0002419)	2.72675609
34	Abnormality of midbrain morphology (HP:0002418)	2.72675609
35	Azoospermia (HP:0000027)	2.72480579
36	Hyperventilation (HP:0002883)	2.70207939
37	Medial flaring of the eyebrow (HP:0010747)	2.69695560
38	Oligodactyly (HP:0012165)	2.63711026
39	Dysdiadochokinesis (HP:0002075)	2.62932823
40	Renal cortical cysts (HP:0000803)	2.62388968
41	Absent septum pellucidum (HP:0001331)	2.58444454
42	Premature ovarian failure (HP:0008209)	2.52066782
43	Congenital primary aphakia (HP:0007707)	2.50380641
44	Lower limb hyperreflexia (HP:0002395)	2.48649583
45	Hypokinesia (HP:0002375)	2.48371861
46	Infertility (HP:0000789)	2.48265305
47	Bifid tongue (HP:0010297)	2.46985146
48	Posterior subcapsular cataract (HP:0007787)	2.41099089
49	Gait imbalance (HP:0002141)	2.40434659
50	Nephrogenic diabetes insipidus (HP:0009806)	2.39044890
51	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36305742
52	Abnormality of the septum pellucidum (HP:0007375)	2.35922632
53	Metaphyseal irregularity (HP:0003025)	2.33917584
54	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.31976904
55	Anhidrosis (HP:0000970)	2.26504647
56	Abnormality of the hip-girdle musculature (HP:0001445)	2.25657051
57	Abnormality of the musculature of the pelvis (HP:0001469)	2.25657051
58	Congenital sensorineural hearing impairment (HP:0008527)	2.24829492
59	Progressive inability to walk (HP:0002505)	2.23691136
60	Tubulointerstitial nephritis (HP:0001970)	2.22251411
61	Generalized aminoaciduria (HP:0002909)	2.20688884
62	Long nose (HP:0003189)	2.18050475
63	Conical tooth (HP:0000698)	2.14483327
64	Abnormal spermatogenesis (HP:0008669)	2.13192728
65	Genital tract atresia (HP:0001827)	2.12753466
66	Mutism (HP:0002300)	2.12104304
67	Truncal obesity (HP:0001956)	2.06909921
68	Urethral obstruction (HP:0000796)	2.04494604
69	Proximal tubulopathy (HP:0000114)	2.03933403
70	Pancreatic cysts (HP:0001737)	2.03879887
71	Nausea (HP:0002018)	2.02227417
72	Hypergonadotropic hypogonadism (HP:0000815)	2.02162346
73	Heterotopia (HP:0002282)	1.98205068
74	Loss of speech (HP:0002371)	1.97240078
75	Abnormality of chromosome stability (HP:0003220)	1.96199758
76	Methylmalonic acidemia (HP:0002912)	1.95894277
77	Medulloblastoma (HP:0002885)	1.95343187
78	Malnutrition (HP:0004395)	1.95003588
79	Striae distensae (HP:0001065)	1.94072925
80	Aplasia/Hypoplasia of the macula (HP:0008059)	1.93409078
81	Abnormality of the anterior chamber (HP:0000593)	1.92584680
82	Abnormality of the renal cortex (HP:0011035)	1.92406531
83	Rhabdomyosarcoma (HP:0002859)	1.90084486
84	Abnormality of chromosome segregation (HP:0002916)	1.88555956
85	Postaxial hand polydactyly (HP:0001162)	1.86881642
86	Broad-based gait (HP:0002136)	1.80913584
87	Volvulus (HP:0002580)	1.80141175
88	Neoplasm of the oral cavity (HP:0100649)	1.80031871
89	Gaze-evoked nystagmus (HP:0000640)	1.79476589
90	Sensory axonal neuropathy (HP:0003390)	1.79347632
91	Carpal bone hypoplasia (HP:0001498)	1.77788270
92	Abnormal lung lobation (HP:0002101)	1.76859150
93	Preaxial hand polydactyly (HP:0001177)	1.76331195
94	Abnormality of the phalanges of the hallux (HP:0010057)	1.74730386
95	Fair hair (HP:0002286)	1.73772736
96	Narrow forehead (HP:0000341)	1.73423548
97	Optic nerve hypoplasia (HP:0000609)	1.72596627
98	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.70802963
99	Complete atrioventricular canal defect (HP:0001674)	1.70622476
100	Maternal diabetes (HP:0009800)	1.70185085

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK3	4.05646203
2	ARAF	3.43489201
3	TRIM28	3.40050191
4	MAP3K4	3.11683460
5	MAP3K13	3.11650920
6	TAOK3	2.85397485
7	NUAK1	2.79221873
8	MAP3K9	2.76273408
9	AKT3	2.73126177
10	MAP2K7	2.58159174
11	STK24	2.47155349
12	BRAF	2.39203522
13	NEK6	2.26867184
14	CDK19	2.11251435
15	NEK9	2.07183652
16	TTK	1.98869929
17	ZAK	1.98673551
18	TNIK	1.83303372
19	CDC7	1.77618487
20	RAF1	1.65063689
21	NTRK2	1.62212839
22	CDK9	1.58613320
23	SRPK1	1.54832258
24	CDK12	1.54233693
25	MET	1.51907652
26	CSNK1G3	1.50167556
27	MOS	1.48496292
28	AURKA	1.46850878
29	CSNK1G1	1.41873468
30	CSNK1A1L	1.36291835
31	PRKCI	1.33471615
32	MAPK13	1.32891785
33	EIF2AK1	1.22803823
34	PLK1	1.22732175
35	DYRK3	1.21968253
36	STK3	1.21657391
37	MST4	1.14312675
38	CSNK1G2	1.12538949
39	PLK3	1.10194296
40	BMPR1B	1.09758530
41	MAP2K4	1.04339354
42	CCNB1	1.02662887
43	FRK	0.98932119
44	STK38L	0.98786099
45	CDK7	0.97087450
46	ACVR1B	0.90875335
47	PIM1	0.87730459
48	PLK4	0.83069556
49	MELK	0.81310866
50	TGFBR2	0.80218194
51	MKNK2	0.76187023
52	FLT3	0.75972353
53	ERBB3	0.74208227
54	DMPK	0.69543284
55	SIK2	0.67870449
56	BCR	0.67712266
57	ATM	0.66811851
58	WNK3	0.63852643
59	MAP3K5	0.63777245
60	CSNK1D	0.61915110
61	TGFBR1	0.61236465
62	CDK8	0.60474585
63	EIF2AK2	0.60353035
64	BRSK2	0.59687533
65	CHEK1	0.58690349
66	KSR1	0.57830493
67	EPHA3	0.57455804
68	KIT	0.55067877
69	ATR	0.54472862
70	VRK1	0.53714822
71	CASK	0.53348912
72	CDK2	0.53161541
73	RPS6KA4	0.51266303
74	BRD4	0.50778168
75	CDK5	0.48923801
76	CHEK2	0.47864478
77	NEK2	0.47664912
78	KSR2	0.47107287
79	PKN1	0.46801572
80	MKNK1	0.46348978
81	IRAK1	0.42894100
82	PLK2	0.42152071
83	PRKG1	0.40977761
84	MAP3K8	0.39548528
85	PINK1	0.37465515
86	CDK1	0.37409968
87	CAMK2A	0.37026960
88	PAK1	0.36603770
89	EPHA4	0.36014403
90	MARK3	0.35720342
91	TNK2	0.34894046
92	PBK	0.34606603
93	OXSR1	0.33363086
94	CHUK	0.32758466
95	LATS1	0.32721442
96	SGK2	0.32241089
97	TIE1	0.31592936
98	BUB1	0.30826452
99	GRK1	0.30746741
100	PRKACA	0.26306410

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.22033108
2	Cell cycle_Homo sapiens_hsa04110	3.61107180
3	Base excision repair_Homo sapiens_hsa03410	3.55609284
4	Mismatch repair_Homo sapiens_hsa03430	3.38504231
5	RNA degradation_Homo sapiens_hsa03018	2.98726374
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.83742560
7	Oocyte meiosis_Homo sapiens_hsa04114	2.77555863
8	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.58030262
9	Caffeine metabolism_Homo sapiens_hsa00232	2.56850095
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.45008463
11	Homologous recombination_Homo sapiens_hsa03440	2.35706062
12	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.32905289
13	Nucleotide excision repair_Homo sapiens_hsa03420	2.29087942
14	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	2.23886988
15	RNA transport_Homo sapiens_hsa03013	2.22313632
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.16512014
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.15796081
18	Non-homologous end-joining_Homo sapiens_hsa03450	2.02093025
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.89496357
20	DNA replication_Homo sapiens_hsa03030	1.88111073
21	Circadian rhythm_Homo sapiens_hsa04710	1.84220443
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.79707616
23	p53 signaling pathway_Homo sapiens_hsa04115	1.72118884
24	Regulation of autophagy_Homo sapiens_hsa04140	1.66224706
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.51504184
26	RNA polymerase_Homo sapiens_hsa03020	1.31950247
27	Fatty acid elongation_Homo sapiens_hsa00062	1.24751998
28	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.19653227
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.11748417
30	Olfactory transduction_Homo sapiens_hsa04740	1.11679066
31	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.09791197
32	Herpes simplex infection_Homo sapiens_hsa05168	1.08093536
33	Propanoate metabolism_Homo sapiens_hsa00640	1.07965294
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.07418845
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.06192983
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.99548274
37	mRNA surveillance pathway_Homo sapiens_hsa03015	0.95967598
38	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.93217074
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.91927894
40	ABC transporters_Homo sapiens_hsa02010	0.91212125
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.87086787
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87052904
43	Purine metabolism_Homo sapiens_hsa00230	0.83609056
44	Phototransduction_Homo sapiens_hsa04744	0.82224196
45	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.81098765
46	Gap junction_Homo sapiens_hsa04540	0.78547275
47	Protein export_Homo sapiens_hsa03060	0.75204689
48	Spliceosome_Homo sapiens_hsa03040	0.74605563
49	FoxO signaling pathway_Homo sapiens_hsa04068	0.71983403
50	Thyroid cancer_Homo sapiens_hsa05216	0.67942965
51	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.66837663
52	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.66256458
53	mTOR signaling pathway_Homo sapiens_hsa04150	0.64095567
54	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.64005306
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58298602
56	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.57995954
57	Proteasome_Homo sapiens_hsa03050	0.51770719
58	Taste transduction_Homo sapiens_hsa04742	0.49786170
59	Phagosome_Homo sapiens_hsa04145	0.47967830
60	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.47620286
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47541205
62	Colorectal cancer_Homo sapiens_hsa05210	0.44360968
63	Long-term depression_Homo sapiens_hsa04730	0.43094689
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.42664174
65	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41447598
66	Folate biosynthesis_Homo sapiens_hsa00790	0.40386118
67	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.39370253
68	Sphingolipid metabolism_Homo sapiens_hsa00600	0.38973798
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.38877309
70	Influenza A_Homo sapiens_hsa05164	0.37196759
71	Legionellosis_Homo sapiens_hsa05134	0.36822526
72	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.35753227
73	Wnt signaling pathway_Homo sapiens_hsa04310	0.35189197
74	Serotonergic synapse_Homo sapiens_hsa04726	0.30612959
75	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.28228530
76	Viral carcinogenesis_Homo sapiens_hsa05203	0.28204804
77	GABAergic synapse_Homo sapiens_hsa04727	0.27203979
78	Hepatitis B_Homo sapiens_hsa05161	0.26985677
79	Nicotine addiction_Homo sapiens_hsa05033	0.25852494
80	Ras signaling pathway_Homo sapiens_hsa04014	0.24608189
81	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.22707017
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.22411345
83	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.22212949
84	Morphine addiction_Homo sapiens_hsa05032	0.21821589
85	Hippo signaling pathway_Homo sapiens_hsa04390	0.19673270
86	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.19668387
87	Peroxisome_Homo sapiens_hsa04146	0.18750910
88	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.18110210
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.18084074
90	MicroRNAs in cancer_Homo sapiens_hsa05206	0.16457091
91	Rheumatoid arthritis_Homo sapiens_hsa05323	0.13644013
92	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.12482633
93	HTLV-I infection_Homo sapiens_hsa05166	0.11585136
94	Small cell lung cancer_Homo sapiens_hsa05222	0.10403449
95	Dopaminergic synapse_Homo sapiens_hsa04728	0.10370192
96	Shigellosis_Homo sapiens_hsa05131	0.10310953
97	Osteoclast differentiation_Homo sapiens_hsa04380	0.09471311
98	Butanoate metabolism_Homo sapiens_hsa00650	0.09213295
99	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.08929372
100	Adherens junction_Homo sapiens_hsa04520	0.08643148

ZNF155

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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