ZNF157

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.24872346
2L-fucose catabolic process (GO:0042355)5.13291254
3fucose catabolic process (GO:0019317)5.13291254
4L-fucose metabolic process (GO:0042354)5.13291254
5DNA deamination (GO:0045006)4.23585717
6negative regulation of telomere maintenance (GO:0032205)4.00787377
7response to pheromone (GO:0019236)3.74826668
8pyrimidine nucleobase catabolic process (GO:0006208)3.70649706
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.59169078
10epithelial cilium movement (GO:0003351)3.52405843
11protein polyglutamylation (GO:0018095)3.48491302
12nonmotile primary cilium assembly (GO:0035058)3.43004477
13cornea development in camera-type eye (GO:0061303)3.38470156
14indolalkylamine metabolic process (GO:0006586)3.34166233
15protein-cofactor linkage (GO:0018065)3.33458579
16nucleobase catabolic process (GO:0046113)3.30544851
17tryptophan catabolic process (GO:0006569)3.29018413
18indole-containing compound catabolic process (GO:0042436)3.29018413
19indolalkylamine catabolic process (GO:0046218)3.29018413
20piRNA metabolic process (GO:0034587)3.25310509
21axoneme assembly (GO:0035082)3.21924589
22detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21899490
23synaptic transmission, cholinergic (GO:0007271)3.18946997
24ubiquinone metabolic process (GO:0006743)3.16644773
25respiratory chain complex IV assembly (GO:0008535)3.07591335
26platelet dense granule organization (GO:0060155)3.06792166
27kynurenine metabolic process (GO:0070189)3.05136512
28regulation of cilium movement (GO:0003352)3.02366638
29ubiquinone biosynthetic process (GO:0006744)3.01309159
30preassembly of GPI anchor in ER membrane (GO:0016254)3.00239274
31tryptophan metabolic process (GO:0006568)2.99949100
32protein complex biogenesis (GO:0070271)2.95168033
33regulation of telomere maintenance (GO:0032204)2.94823190
34somite rostral/caudal axis specification (GO:0032525)2.93761690
35NADH dehydrogenase complex assembly (GO:0010257)2.93760321
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93760321
37mitochondrial respiratory chain complex I assembly (GO:0032981)2.93760321
38nephron tubule morphogenesis (GO:0072078)2.92073046
39nephron epithelium morphogenesis (GO:0072088)2.92073046
40detection of light stimulus involved in sensory perception (GO:0050962)2.91380390
41detection of light stimulus involved in visual perception (GO:0050908)2.91380390
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.90797133
43sulfation (GO:0051923)2.90426227
44transmission of nerve impulse (GO:0019226)2.89607280
45water-soluble vitamin biosynthetic process (GO:0042364)2.87536712
46negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86767667
47postsynaptic membrane organization (GO:0001941)2.81766482
48protein localization to cilium (GO:0061512)2.80796995
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.80336914
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79951076
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79951076
52neuronal action potential (GO:0019228)2.78946376
53cilium movement (GO:0003341)2.78902226
54cellular ketone body metabolic process (GO:0046950)2.78408176
55regulation of mesoderm development (GO:2000380)2.77037136
56mitochondrial respiratory chain complex assembly (GO:0033108)2.76475055
57mannosylation (GO:0097502)2.74939426
58cilium morphogenesis (GO:0060271)2.74291050
59positive regulation of prostaglandin secretion (GO:0032308)2.73775806
60kidney morphogenesis (GO:0060993)2.70236852
61cytochrome complex assembly (GO:0017004)2.69738851
62somite development (GO:0061053)2.68949638
63photoreceptor cell maintenance (GO:0045494)2.68040469
64fucosylation (GO:0036065)2.67867283
65ATP synthesis coupled proton transport (GO:0015986)2.66300854
66energy coupled proton transport, down electrochemical gradient (GO:0015985)2.66300854
67primary amino compound metabolic process (GO:1901160)2.65802571
68gamma-aminobutyric acid transport (GO:0015812)2.64309153
69neural tube formation (GO:0001841)2.63753862
70cilium organization (GO:0044782)2.62259809
71regulation of neurotransmitter uptake (GO:0051580)2.61974685
72DNA methylation involved in gamete generation (GO:0043046)2.61406484
73indole-containing compound metabolic process (GO:0042430)2.61120372
74photoreceptor cell development (GO:0042461)2.60411234
75cellular response to ATP (GO:0071318)2.59847976
76regulation of action potential (GO:0098900)2.58001586
77cellular biogenic amine catabolic process (GO:0042402)2.57344939
78amine catabolic process (GO:0009310)2.57344939
79reflex (GO:0060004)2.55532052
80ketone body metabolic process (GO:1902224)2.54069757
81positive regulation of fatty acid transport (GO:2000193)2.53762909
82intraciliary transport (GO:0042073)2.53600159
83cilium assembly (GO:0042384)2.52697522
84negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52049702
85regulation of rhodopsin mediated signaling pathway (GO:0022400)2.51945665
86spinal cord motor neuron differentiation (GO:0021522)2.51768245
87cAMP catabolic process (GO:0006198)2.50913105
88cellular anion homeostasis (GO:0030002)2.50122755
89positive regulation of oligodendrocyte differentiation (GO:0048714)2.49711715
90behavioral response to ethanol (GO:0048149)2.49361756
91rRNA catabolic process (GO:0016075)2.47930768
92retinal cone cell development (GO:0046549)2.47571470
93negative regulation of mast cell activation (GO:0033004)2.47173681
94dendritic spine morphogenesis (GO:0060997)2.46746510
95reciprocal DNA recombination (GO:0035825)2.44185265
96reciprocal meiotic recombination (GO:0007131)2.44185265
97GPI anchor metabolic process (GO:0006505)2.42904641
98DNA double-strand break processing (GO:0000729)2.42289525
99negative regulation of reactive oxygen species metabolic process (GO:2000378)2.42271211
100glycerophospholipid catabolic process (GO:0046475)2.42003804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela4.08477702
2EZH2_22144423_ChIP-Seq_EOC_Human3.39048221
3VDR_22108803_ChIP-Seq_LS180_Human3.22405631
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.93542148
5GBX2_23144817_ChIP-Seq_PC3_Human2.78586692
6IGF1R_20145208_ChIP-Seq_DFB_Human2.51890391
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49231078
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48981647
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34840825
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30848811
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24318262
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14624170
13TAF15_26573619_Chip-Seq_HEK293_Human2.13334932
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08440837
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04792075
16FUS_26573619_Chip-Seq_HEK293_Human2.02808248
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.02137719
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99738379
19EWS_26573619_Chip-Seq_HEK293_Human1.96354058
20P300_19829295_ChIP-Seq_ESCs_Human1.90072105
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.79922760
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73541099
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70854109
24ER_23166858_ChIP-Seq_MCF-7_Human1.65121625
25IRF1_19129219_ChIP-ChIP_H3396_Human1.64743843
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64436933
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.62550647
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.62442545
29TP53_22573176_ChIP-Seq_HFKS_Human1.61563593
30REST_21632747_ChIP-Seq_MESCs_Mouse1.57393789
31MYC_18940864_ChIP-ChIP_HL60_Human1.56885867
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56185888
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56152919
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51373118
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.50325154
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47396085
37RNF2_27304074_Chip-Seq_NSC_Mouse1.42864777
38BCAT_22108803_ChIP-Seq_LS180_Human1.42174603
39* EST1_17652178_ChIP-ChIP_JURKAT_Human1.41221906
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.35059937
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.33847058
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32897520
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32820534
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30993977
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30993977
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30897797
47CBP_20019798_ChIP-Seq_JUKART_Human1.30897797
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30385676
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29673945
50STAT3_23295773_ChIP-Seq_U87_Human1.29407793
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29311448
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.29311448
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28028415
54AR_25329375_ChIP-Seq_VCAP_Human1.28022342
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.28002060
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27777576
57TCF4_23295773_ChIP-Seq_U87_Human1.26244168
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24321311
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24088673
60NCOR_22424771_ChIP-Seq_293T_Human1.23775643
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.23453697
62NANOG_19829295_ChIP-Seq_ESCs_Human1.22708135
63SOX2_19829295_ChIP-Seq_ESCs_Human1.22708135
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21736929
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.21133892
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19402855
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17030083
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16304697
69TCF4_22108803_ChIP-Seq_LS180_Human1.15976518
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15904512
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15191328
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.14135700
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.13821455
74AR_20517297_ChIP-Seq_VCAP_Human1.13702283
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13301822
76RUNX2_22187159_ChIP-Seq_PCA_Human1.12714661
77HOXB7_26014856_ChIP-Seq_BT474_Human1.12648187
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12423702
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11999118
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11856197
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11348235
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.10482483
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10302085
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07553172
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07311012
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06144639
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.05837112
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.05239338
89ELK1_19687146_ChIP-ChIP_HELA_Human1.04428640
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03980619
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.01700105
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.01160698
93EZH2_27294783_Chip-Seq_ESCs_Mouse0.99325630
94* TAF2_19829295_ChIP-Seq_ESCs_Human0.99116447
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98811026
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98637054
97MYC_19829295_ChIP-Seq_ESCs_Human0.98057371
98VDR_23849224_ChIP-Seq_CD4+_Human0.97545037
99ERA_21632823_ChIP-Seq_H3396_Human0.96621217
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96496516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.00069845
2MP0002653_abnormal_ependyma_morphology2.78580616
3MP0008877_abnormal_DNA_methylation2.43865796
4MP0005645_abnormal_hypothalamus_physiol2.39077383
5MP0005551_abnormal_eye_electrophysiolog2.31456933
6MP0001968_abnormal_touch/_nociception2.28042612
7MP0002234_abnormal_pharynx_morphology2.15250317
8MP0003880_abnormal_central_pattern2.09242833
9MP0002837_dystrophic_cardiac_calcinosis2.08732026
10MP0006072_abnormal_retinal_apoptosis2.05127583
11MP0006276_abnormal_autonomic_nervous2.04505807
12MP0002638_abnormal_pupillary_reflex2.04391761
13MP0003195_calcinosis2.03297703
14MP0003787_abnormal_imprinting1.95437254
15MP0009046_muscle_twitch1.95002243
16MP0004147_increased_porphyrin_level1.90475016
17MP0003646_muscle_fatigue1.88490019
18MP0008872_abnormal_physiological_respon1.86999047
19MP0001986_abnormal_taste_sensitivity1.85823717
20MP0009745_abnormal_behavioral_response1.85758399
21MP0004885_abnormal_endolymph1.82995182
22MP0004133_heterotaxia1.82530541
23MP0002736_abnormal_nociception_after1.81313147
24MP0004142_abnormal_muscle_tone1.75461795
25MP0004043_abnormal_pH_regulation1.75195512
26MP0002876_abnormal_thyroid_physiology1.71032097
27MP0008875_abnormal_xenobiotic_pharmacok1.68631858
28MP0005253_abnormal_eye_physiology1.68516773
29MP0000569_abnormal_digit_pigmentation1.67965165
30MP0002138_abnormal_hepatobiliary_system1.66816711
31MP0006292_abnormal_olfactory_placode1.66108770
32MP0001529_abnormal_vocalization1.65584626
33MP0002735_abnormal_chemical_nociception1.65414758
34MP0002272_abnormal_nervous_system1.64743531
35MP0004742_abnormal_vestibular_system1.58034274
36MP0005084_abnormal_gallbladder_morpholo1.54683672
37MP0000372_irregular_coat_pigmentation1.54311244
38MP0001984_abnormal_olfaction1.52344457
39MP0003136_yellow_coat_color1.50557086
40MP0005646_abnormal_pituitary_gland1.47161067
41MP0002938_white_spotting1.46926144
42MP0002572_abnormal_emotion/affect_behav1.45377648
43MP0001485_abnormal_pinna_reflex1.42916645
44MP0001486_abnormal_startle_reflex1.41958250
45MP0003011_delayed_dark_adaptation1.41703338
46MP0000631_abnormal_neuroendocrine_gland1.41402092
47MP0001501_abnormal_sleep_pattern1.40391337
48MP0002163_abnormal_gland_morphology1.35119357
49MP0000427_abnormal_hair_cycle1.31933227
50MP0002064_seizures1.29642489
51MP0002557_abnormal_social/conspecific_i1.26191307
52MP0008995_early_reproductive_senescence1.25705285
53MP0003635_abnormal_synaptic_transmissio1.25453927
54MP0002067_abnormal_sensory_capabilities1.22540110
55MP0008789_abnormal_olfactory_epithelium1.21500418
56MP0002733_abnormal_thermal_nociception1.20787516
57MP0001970_abnormal_pain_threshold1.20216249
58MP0002277_abnormal_respiratory_mucosa1.19798352
59MP0002751_abnormal_autonomic_nervous1.18687230
60MP0005167_abnormal_blood-brain_barrier1.16723726
61MP0002063_abnormal_learning/memory/cond1.14951904
62MP0000778_abnormal_nervous_system1.10962350
63MP0002928_abnormal_bile_duct1.10488199
64MP0008058_abnormal_DNA_repair1.10059772
65MP0004145_abnormal_muscle_electrophysio1.09881632
66MP0003121_genomic_imprinting1.07563708
67MP0005386_behavior/neurological_phenoty1.06098997
68MP0004924_abnormal_behavior1.06098997
69MP0003878_abnormal_ear_physiology1.06004906
70MP0005377_hearing/vestibular/ear_phenot1.06004906
71MP0005195_abnormal_posterior_eye1.05170973
72MP0001905_abnormal_dopamine_level1.04515784
73MP0002734_abnormal_mechanical_nocicepti1.03681575
74MP0005389_reproductive_system_phenotype1.03574331
75MP0002752_abnormal_somatic_nervous1.03123109
76MP0000026_abnormal_inner_ear1.01609942
77MP0001919_abnormal_reproductive_system0.98947681
78MP0005423_abnormal_somatic_nervous0.98546615
79MP0002184_abnormal_innervation0.97732449
80MP0001188_hyperpigmentation0.96802053
81MP0000647_abnormal_sebaceous_gland0.93394469
82MP0002909_abnormal_adrenal_gland0.92995908
83MP0001502_abnormal_circadian_rhythm0.92498451
84MP0005499_abnormal_olfactory_system0.91119955
85MP0005394_taste/olfaction_phenotype0.91119955
86MP0003283_abnormal_digestive_organ0.90889139
87MP0005379_endocrine/exocrine_gland_phen0.90678352
88MP0009379_abnormal_foot_pigmentation0.89535722
89MP0002160_abnormal_reproductive_system0.88088823
90MP0003122_maternal_imprinting0.87686020
91MP0003567_abnormal_fetal_cardiomyocyte0.87583670
92MP0001963_abnormal_hearing_physiology0.86555188
93MP0002095_abnormal_skin_pigmentation0.84835320
94MP0005174_abnormal_tail_pigmentation0.84774496
95MP0003119_abnormal_digestive_system0.84570356
96MP0010386_abnormal_urinary_bladder0.84406224
97MP0000049_abnormal_middle_ear0.81134525
98MP0000383_abnormal_hair_follicle0.81037247
99MP0002882_abnormal_neuron_morphology0.79914811
100MP0001324_abnormal_eye_pigmentation0.79298554

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.63849339
2Pancreatic fibrosis (HP:0100732)4.32107052
3True hermaphroditism (HP:0010459)4.07326383
4Abnormality of midbrain morphology (HP:0002418)3.99238699
5Molar tooth sign on MRI (HP:0002419)3.99238699
6Congenital stationary night blindness (HP:0007642)3.85748027
7Type II lissencephaly (HP:0007260)3.75974387
8Nephronophthisis (HP:0000090)3.59860230
9Medial flaring of the eyebrow (HP:0010747)3.44810702
10Abnormality of the renal medulla (HP:0100957)3.20695117
11Abnormality of the renal cortex (HP:0011035)3.08271200
12Cystic liver disease (HP:0006706)2.92891491
13Gait imbalance (HP:0002141)2.82468508
14Pendular nystagmus (HP:0012043)2.72400664
15Congenital primary aphakia (HP:0007707)2.71311547
16Cerebellar dysplasia (HP:0007033)2.68023462
17Tubular atrophy (HP:0000092)2.66232081
18Polydipsia (HP:0001959)2.63385628
19Abnormal drinking behavior (HP:0030082)2.63385628
20Chronic hepatic failure (HP:0100626)2.61801025
21Abolished electroretinogram (ERG) (HP:0000550)2.60313583
22Attenuation of retinal blood vessels (HP:0007843)2.59438399
23Anterior segment dysgenesis (HP:0007700)2.56633531
24Nephrogenic diabetes insipidus (HP:0009806)2.56606378
25Abnormal rod and cone electroretinograms (HP:0008323)2.55399598
26Acute necrotizing encephalopathy (HP:0006965)2.51673023
27Lissencephaly (HP:0001339)2.46865418
28Abnormality of alanine metabolism (HP:0010916)2.45828584
29Hyperalaninemia (HP:0003348)2.45828584
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45828584
31Sclerocornea (HP:0000647)2.44440635
32Broad-based gait (HP:0002136)2.30526668
33Limb dystonia (HP:0002451)2.30002668
34Congenital, generalized hypertrichosis (HP:0004540)2.29664343
35Inability to walk (HP:0002540)2.29562792
36Hyperventilation (HP:0002883)2.28789933
37Abnormal biliary tract physiology (HP:0012439)2.23751108
38Bile duct proliferation (HP:0001408)2.23751108
39Mitochondrial inheritance (HP:0001427)2.23185931
40Anencephaly (HP:0002323)2.22087608
41Congenital hepatic fibrosis (HP:0002612)2.17878085
42Abnormal mitochondria in muscle tissue (HP:0008316)2.17388143
43Acute encephalopathy (HP:0006846)2.17299649
44Progressive macrocephaly (HP:0004481)2.16018276
45Optic nerve hypoplasia (HP:0000609)2.13853159
46Renal cortical cysts (HP:0000803)2.13668859
47Genital tract atresia (HP:0001827)2.13157712
48Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13107594
49Polyuria (HP:0000103)2.12976372
50Vaginal atresia (HP:0000148)2.12732645
51Increased CSF lactate (HP:0002490)2.11374630
52Optic disc pallor (HP:0000543)2.08328797
53Retinal dysplasia (HP:0007973)2.07554718
54Lipid accumulation in hepatocytes (HP:0006561)2.07260552
55Concave nail (HP:0001598)2.06725685
56Abnormal respiratory epithelium morphology (HP:0012253)2.06687584
57Abnormal respiratory motile cilium morphology (HP:0005938)2.06687584
58Birth length less than 3rd percentile (HP:0003561)2.06285698
59Male pseudohermaphroditism (HP:0000037)2.05652847
60Genetic anticipation (HP:0003743)2.04400674
61Furrowed tongue (HP:0000221)2.03385920
62Decreased central vision (HP:0007663)2.02020470
63Gaze-evoked nystagmus (HP:0000640)2.01612395
643-Methylglutaconic aciduria (HP:0003535)2.01606359
65Progressive cerebellar ataxia (HP:0002073)2.01015402
66Pachygyria (HP:0001302)2.00583808
67Occipital encephalocele (HP:0002085)2.00371436
68Decreased circulating renin level (HP:0003351)1.99785357
69Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99713501
70Postaxial foot polydactyly (HP:0001830)1.99687425
71Increased corneal curvature (HP:0100692)1.99638755
72Keratoconus (HP:0000563)1.99638755
73Hypothermia (HP:0002045)1.98176516
74Poor coordination (HP:0002370)1.96857704
75Severe muscular hypotonia (HP:0006829)1.95086357
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.94802713
77Large for gestational age (HP:0001520)1.93820568
78Aplasia/hypoplasia of the uterus (HP:0008684)1.93414548
79Febrile seizures (HP:0002373)1.92347866
80Absent/shortened dynein arms (HP:0200106)1.90311984
81Dynein arm defect of respiratory motile cilia (HP:0012255)1.90311984
82Aplasia/Hypoplasia of the spleen (HP:0010451)1.89665421
83Agitation (HP:0000713)1.89163145
84Aplasia/Hypoplasia of the patella (HP:0006498)1.88234972
85Patellar aplasia (HP:0006443)1.86280711
86Stomach cancer (HP:0012126)1.85770964
87Focal motor seizures (HP:0011153)1.85638089
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.85396030
89Specific learning disability (HP:0001328)1.84796961
90Progressive inability to walk (HP:0002505)1.82749012
91Epileptic encephalopathy (HP:0200134)1.79847623
92Intestinal atresia (HP:0011100)1.78977602
93Increased hepatocellular lipid droplets (HP:0006565)1.77986740
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76021139
95Dandy-Walker malformation (HP:0001305)1.75337241
96Drooling (HP:0002307)1.74246047
97Postaxial hand polydactyly (HP:0001162)1.73745924
98Chorioretinal atrophy (HP:0000533)1.73310183
99Hepatocellular necrosis (HP:0001404)1.72519701
100Abnormality of macular pigmentation (HP:0008002)1.72285828

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.29395475
2FRK3.95419708
3ADRBK23.27460841
4WNK43.01397834
5MAP4K22.88881503
6TAOK32.71548805
7BMPR1B2.66829713
8ZAK2.59895834
9WNK32.47379364
10CASK2.28763011
11MAP3K42.28297965
12GRK12.16127386
13NUAK12.15152836
14PIK3CA1.95197211
15OXSR11.88139880
16PINK11.77022841
17CAMKK21.75005854
18INSRR1.74110246
19STK391.56749366
20MAPK131.53918790
21DAPK21.52568203
22MARK11.50107167
23CDK191.38042022
24MAP2K71.31744050
25BCKDK1.26975248
26PAK31.25753310
27ACVR1B1.24498037
28PRKCG1.22046866
29ADRBK11.19340878
30DYRK21.19245793
31TXK1.16597527
32BCR1.04786654
33MUSK1.03083368
34MAPK151.01707719
35NTRK30.99251936
36CSNK1G30.97892936
37CSNK1G20.89949825
38CSNK1G10.89123928
39MKNK20.88552117
40TIE10.85914617
41PLK20.85674403
42GRK70.83698605
43CSNK1A1L0.82925855
44TRIM280.81703712
45TGFBR10.81072910
46PRKCE0.80767304
47PHKG10.77310963
48PHKG20.77310963
49TNIK0.77123843
50PNCK0.76788200
51SIK20.73629639
52CAMK1D0.72163054
53NEK20.71880090
54EPHA40.70456096
55STK160.68012751
56STK38L0.67780926
57VRK10.67759440
58TSSK60.67005332
59NTRK20.61714517
60RPS6KA50.61091286
61MAP2K60.58854849
62CAMK10.58062432
63VRK20.57369367
64MINK10.56291916
65PRKCQ0.55682302
66CAMK2A0.55628111
67KIT0.51943358
68MAP2K40.51433614
69CCNB10.49430107
70PLK40.49218056
71PRKACA0.48841778
72GRK60.47683767
73DYRK30.47422981
74GRK50.46630964
75EPHA30.44365994
76DYRK1A0.44184454
77ERBB30.43808899
78CSNK1D0.42044418
79MKNK10.41072114
80PTK2B0.40717690
81LIMK10.40655576
82PKN10.40346398
83CSNK1A10.40264149
84BRSK20.39442646
85STK30.39414853
86IKBKB0.39277300
87PRKAA10.38966739
88TAF10.37064395
89STK110.36583483
90CAMK40.35824337
91TEC0.33901353
92PLK30.33601611
93MAP2K20.32976634
94PRKG10.32640872
95IRAK10.32239524
96CHUK0.31652285
97CAMKK10.31146190
98FGFR20.30044481
99OBSCN0.29677269
100PRKCA0.28472341

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.89502017
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.85380716
3Linoleic acid metabolism_Homo sapiens_hsa005912.72770432
4Oxidative phosphorylation_Homo sapiens_hsa001902.71181502
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.63280501
6Nicotine addiction_Homo sapiens_hsa050332.56936636
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.55911689
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43162612
9Nitrogen metabolism_Homo sapiens_hsa009102.27191415
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.20625424
11Selenocompound metabolism_Homo sapiens_hsa004502.15517555
12Parkinsons disease_Homo sapiens_hsa050122.09077943
13Caffeine metabolism_Homo sapiens_hsa002322.05675668
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.05307373
15Butanoate metabolism_Homo sapiens_hsa006502.03103332
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01409313
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.89357000
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86057760
19Ether lipid metabolism_Homo sapiens_hsa005651.77031983
20Basal transcription factors_Homo sapiens_hsa030221.62027839
21Cardiac muscle contraction_Homo sapiens_hsa042601.60769290
22Protein export_Homo sapiens_hsa030601.58328885
23Tryptophan metabolism_Homo sapiens_hsa003801.52222638
24Morphine addiction_Homo sapiens_hsa050321.52017602
25Homologous recombination_Homo sapiens_hsa034401.51707772
26Fanconi anemia pathway_Homo sapiens_hsa034601.49422979
27RNA polymerase_Homo sapiens_hsa030201.47591915
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47332774
29Taste transduction_Homo sapiens_hsa047421.43107614
30Huntingtons disease_Homo sapiens_hsa050161.34939199
31Olfactory transduction_Homo sapiens_hsa047401.31167339
32Alzheimers disease_Homo sapiens_hsa050101.30998432
33GABAergic synapse_Homo sapiens_hsa047271.27687145
34Collecting duct acid secretion_Homo sapiens_hsa049661.17471518
35Ribosome_Homo sapiens_hsa030101.16492856
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16209800
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12358827
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10281928
39Serotonergic synapse_Homo sapiens_hsa047261.09693903
40Propanoate metabolism_Homo sapiens_hsa006401.09392317
41Circadian entrainment_Homo sapiens_hsa047131.08888073
42RNA degradation_Homo sapiens_hsa030181.08085190
43Peroxisome_Homo sapiens_hsa041461.05261644
44Glutamatergic synapse_Homo sapiens_hsa047241.04251805
45Arachidonic acid metabolism_Homo sapiens_hsa005901.03813400
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.00911632
47Insulin secretion_Homo sapiens_hsa049110.99408006
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.98251351
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97440652
50Chemical carcinogenesis_Homo sapiens_hsa052040.92719749
51ABC transporters_Homo sapiens_hsa020100.92611589
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87979030
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.87301963
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84571058
55Regulation of autophagy_Homo sapiens_hsa041400.83021086
56Type I diabetes mellitus_Homo sapiens_hsa049400.82137700
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79497771
58Retinol metabolism_Homo sapiens_hsa008300.78348073
59Fat digestion and absorption_Homo sapiens_hsa049750.77552422
60Primary immunodeficiency_Homo sapiens_hsa053400.76158024
61Ovarian steroidogenesis_Homo sapiens_hsa049130.69327568
62Dopaminergic synapse_Homo sapiens_hsa047280.68166740
63One carbon pool by folate_Homo sapiens_hsa006700.66882476
64beta-Alanine metabolism_Homo sapiens_hsa004100.66832941
65Purine metabolism_Homo sapiens_hsa002300.64599239
66Graft-versus-host disease_Homo sapiens_hsa053320.64359645
67Histidine metabolism_Homo sapiens_hsa003400.59141890
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59136354
69Metabolic pathways_Homo sapiens_hsa011000.56462017
70Calcium signaling pathway_Homo sapiens_hsa040200.56103771
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54719357
72Salivary secretion_Homo sapiens_hsa049700.53242801
73Allograft rejection_Homo sapiens_hsa053300.52815190
74Glycerolipid metabolism_Homo sapiens_hsa005610.50992444
75Autoimmune thyroid disease_Homo sapiens_hsa053200.50989440
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50038493
77Steroid biosynthesis_Homo sapiens_hsa001000.48153786
78Proteasome_Homo sapiens_hsa030500.47396896
79African trypanosomiasis_Homo sapiens_hsa051430.44321225
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44096458
81Mineral absorption_Homo sapiens_hsa049780.43461048
82Synaptic vesicle cycle_Homo sapiens_hsa047210.43097980
83Cocaine addiction_Homo sapiens_hsa050300.42650606
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42586708
85Amphetamine addiction_Homo sapiens_hsa050310.42548258
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41844081
87Hedgehog signaling pathway_Homo sapiens_hsa043400.41509794
88Cholinergic synapse_Homo sapiens_hsa047250.40824461
89Asthma_Homo sapiens_hsa053100.39519008
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39210469
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37798574
92Axon guidance_Homo sapiens_hsa043600.37787073
93Rheumatoid arthritis_Homo sapiens_hsa053230.36852136
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35877632
95Basal cell carcinoma_Homo sapiens_hsa052170.35840964
96Dorso-ventral axis formation_Homo sapiens_hsa043200.35480233
97Oxytocin signaling pathway_Homo sapiens_hsa049210.35302834
98cAMP signaling pathway_Homo sapiens_hsa040240.34011290
99Long-term depression_Homo sapiens_hsa047300.33176149
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31441269

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