ZNF165

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded protein may play a role in spermatogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lactate metabolic process (GO:0006089)5.03558734
2keratinocyte development (GO:0003334)4.58851552
3cellular ketone body metabolic process (GO:0046950)4.29797279
4protein K11-linked deubiquitination (GO:0035871)4.24488618
5ER overload response (GO:0006983)3.99896111
6single strand break repair (GO:0000012)3.88628067
7ketone body metabolic process (GO:1902224)3.74818453
8regulation of glucokinase activity (GO:0033131)3.69715458
9regulation of hexokinase activity (GO:1903299)3.69715458
10respiratory chain complex IV assembly (GO:0008535)3.68885688
11positive regulation of protein autophosphorylation (GO:0031954)3.60097239
12ribosome assembly (GO:0042255)3.59670310
13negative regulation of dendrite morphogenesis (GO:0050774)3.55443728
14regulation of meiosis I (GO:0060631)3.55151449
15protein K6-linked ubiquitination (GO:0085020)3.54206940
16rRNA methylation (GO:0031167)3.53234002
17rRNA modification (GO:0000154)3.51660350
18water-soluble vitamin biosynthetic process (GO:0042364)3.46816549
19positive regulation of respiratory burst (GO:0060267)3.37251450
20synapsis (GO:0007129)3.30520529
21pteridine-containing compound biosynthetic process (GO:0042559)3.29485390
22regulation of Rac protein signal transduction (GO:0035020)3.27711564
23cytochrome complex assembly (GO:0017004)3.27633817
24regulation of centriole replication (GO:0046599)3.20781209
25chemosensory behavior (GO:0007635)3.18019895
26regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14660315
27regulation of mitotic spindle checkpoint (GO:1903504)3.14660315
28regulation of mRNA 3-end processing (GO:0031440)3.14522110
29proteasome assembly (GO:0043248)3.13236842
30protein complex biogenesis (GO:0070271)3.11020505
31axoneme assembly (GO:0035082)3.09536489
32regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.01486699
33telomere maintenance via telomerase (GO:0007004)2.94723537
34positive regulation of histone H3-K4 methylation (GO:0051571)2.94291385
35mitochondrial respiratory chain complex assembly (GO:0033108)2.94170293
36positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.91917363
37regulation of cilium movement (GO:0003352)2.89286026
38zinc ion transport (GO:0006829)2.84088397
39metaphase plate congression (GO:0051310)2.80252729
40somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80138927
41somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80138927
42isotype switching (GO:0045190)2.80138927
43nodal signaling pathway (GO:0038092)2.76895987
44negative regulation of DNA-dependent DNA replication (GO:2000104)2.76034619
45S-adenosylmethionine metabolic process (GO:0046500)2.75770381
46positive regulation of mRNA processing (GO:0050685)2.75261574
47regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.75027891
48positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.75027891
49negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73524063
50negative regulation of translation, ncRNA-mediated (GO:0040033)2.73524063
51regulation of translation, ncRNA-mediated (GO:0045974)2.73524063
52positive regulation of mRNA 3-end processing (GO:0031442)2.73222232
53regulation of mitochondrial translation (GO:0070129)2.69219555
54peptidyl-histidine modification (GO:0018202)2.67819526
55piRNA metabolic process (GO:0034587)2.67693504
56intestinal epithelial cell development (GO:0060576)2.66214197
57negative regulation of JUN kinase activity (GO:0043508)2.66064541
58artery smooth muscle contraction (GO:0014824)2.64729643
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64619447
60mitochondrial respiratory chain complex I assembly (GO:0032981)2.64619447
61NADH dehydrogenase complex assembly (GO:0010257)2.64619447
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.64063874
63DNA double-strand break processing (GO:0000729)2.62882507
64DNA methylation involved in gamete generation (GO:0043046)2.62427877
65cell wall macromolecule catabolic process (GO:0016998)2.62351158
66regulation of acyl-CoA biosynthetic process (GO:0050812)2.60367917
67nuclear pore complex assembly (GO:0051292)2.60180061
68termination of RNA polymerase III transcription (GO:0006386)2.59684434
69transcription elongation from RNA polymerase III promoter (GO:0006385)2.59684434
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59617685
71negative regulation of execution phase of apoptosis (GO:1900118)2.58798572
72signal peptide processing (GO:0006465)2.56820274
73regulation of cellular amino acid metabolic process (GO:0006521)2.55971862
74branched-chain amino acid catabolic process (GO:0009083)2.55713212
75L-alpha-amino acid transmembrane transport (GO:1902475)2.55534237
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55292956
77negative regulation of dendrite development (GO:2000171)2.53626301
78transepithelial transport (GO:0070633)2.53333865
79positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.52761747
80regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.52761747
81positive regulation of cell size (GO:0045793)2.52686477
82detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52285039
83positive regulation of mRNA metabolic process (GO:1903313)2.51839266
84Leydig cell differentiation (GO:0033327)2.51757913
85regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.47234483
86RNA destabilization (GO:0050779)2.45324388
87negative regulation of neurological system process (GO:0031645)2.43949590
88sperm motility (GO:0030317)2.41566924
89positive regulation of macroautophagy (GO:0016239)2.41451855
90regulation of protein autophosphorylation (GO:0031952)2.38913547
91RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.38750172
92protein targeting to Golgi (GO:0000042)2.38454915
93insulin secretion (GO:0030073)2.37802960
94dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.37795539
95sphingomyelin metabolic process (GO:0006684)2.37376587
96replication fork processing (GO:0031297)2.36544357
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.36519151
98regulation of respiratory burst (GO:0060263)2.34947167
99positive regulation of mRNA catabolic process (GO:0061014)2.34491539
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.33253434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.25499760
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.77338291
3VDR_22108803_ChIP-Seq_LS180_Human2.77812761
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.69205688
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.56497352
6NOTCH1_21737748_ChIP-Seq_TLL_Human2.41610780
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39850329
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.33225603
9ELK1_19687146_ChIP-ChIP_HELA_Human2.30928466
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27756626
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.16874917
12ZNF274_21170338_ChIP-Seq_K562_Hela2.16313576
13FUS_26573619_Chip-Seq_HEK293_Human2.09888988
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02194019
15ESR1_21235772_ChIP-Seq_MCF-7_Human1.98793592
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98475065
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95296181
18PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89055568
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.83942030
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79987603
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.77930588
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70485825
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68438627
24P300_19829295_ChIP-Seq_ESCs_Human1.66265917
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59926617
26ER_23166858_ChIP-Seq_MCF-7_Human1.59416929
27VDR_23849224_ChIP-Seq_CD4+_Human1.57507092
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56436961
29EWS_26573619_Chip-Seq_HEK293_Human1.55029028
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53168357
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50679654
32FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45190885
33FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.45138372
34CDX2_22108803_ChIP-Seq_LS180_Human1.43196630
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42397022
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41364030
37FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.40346599
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36825042
39RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36202521
40NANOG_19829295_ChIP-Seq_ESCs_Human1.35070721
41SOX2_19829295_ChIP-Seq_ESCs_Human1.35070721
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34145610
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.34021490
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33806305
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33590517
46PHF8_20622853_ChIP-Seq_HELA_Human1.33376701
47* ETS1_20019798_ChIP-Seq_JURKAT_Human1.32116758
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.31205411
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31188159
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30741972
51FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28972669
52* FOXP3_21729870_ChIP-Seq_TREG_Human1.26876306
53CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.26448469
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23687469
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22327321
56HNFA_21074721_ChIP-Seq_CACO-2_Human1.21971083
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20800287
58RBPJ_21746931_ChIP-Seq_IB4_Human1.20534983
59GBX2_23144817_ChIP-Seq_PC3_Human1.19930482
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19238192
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18590012
62CBP_20019798_ChIP-Seq_JUKART_Human1.18590012
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17958779
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17873755
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.17583007
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17583007
67MYC_18940864_ChIP-ChIP_HL60_Human1.17162236
68TAF15_26573619_Chip-Seq_HEK293_Human1.16716308
69TCF4_22108803_ChIP-Seq_LS180_Human1.16349483
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14103124
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12195521
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12159953
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12157647
74ELF5_23300383_ChIP-Seq_T47D_Human1.11306573
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11173321
76GATA3_24758297_ChIP-Seq_MCF-7_Human1.11130617
77GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.11026460
78HOXB7_26014856_ChIP-Seq_BT474_Human1.10276745
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.10235873
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09942499
81GATA6_21074721_ChIP-Seq_CACO-2_Human1.09431726
82* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08889535
83GATA4_25053715_ChIP-Seq_YYC3_Human1.07807152
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.07405187
85NANOG_16153702_ChIP-ChIP_HESCs_Human1.07046227
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05808475
87ELK1_22589737_ChIP-Seq_MCF10A_Human1.04969925
88GATA6_25053715_ChIP-Seq_YYC3_Human1.04771871
89NFYB_21822215_ChIP-Seq_K562_Human1.04711954
90PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03089867
91AR_25329375_ChIP-Seq_VCAP_Human1.02965162
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.02924893
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02864900
94ETV1_20927104_ChIP-Seq_GIST48_Human1.02432630
95KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02020287
96ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01345873
97BCAT_22108803_ChIP-Seq_LS180_Human1.00508136
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.00343190
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.00266256
100P300_18555785_Chip-Seq_ESCs_Mouse0.99241720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.59722864
2MP0002254_reproductive_system_inflammat3.48085472
3MP0003786_premature_aging2.87856220
4MP0008057_abnormal_DNA_replication2.72792621
5MP0003950_abnormal_plasma_membrane2.68865858
6MP0003195_calcinosis2.62962840
7MP0008058_abnormal_DNA_repair2.48464651
8MP0003718_maternal_effect2.45516617
9MP0005670_abnormal_white_adipose2.39769722
10MP0004019_abnormal_vitamin_homeostasis2.28725649
11MP0005379_endocrine/exocrine_gland_phen2.23487941
12MP0003693_abnormal_embryo_hatching2.11673362
13MP0005410_abnormal_fertilization2.11212140
14MP0008007_abnormal_cellular_replicative2.05295415
15MP0002876_abnormal_thyroid_physiology1.91181041
16MP0009780_abnormal_chondrocyte_physiolo1.89553725
17MP0000613_abnormal_salivary_gland1.84602412
18MP0010386_abnormal_urinary_bladder1.82960454
19MP0003941_abnormal_skin_development1.78815434
20MP0000516_abnormal_urinary_system1.75672235
21MP0005367_renal/urinary_system_phenotyp1.75672235
22MP0005646_abnormal_pituitary_gland1.72396025
23MP0001984_abnormal_olfaction1.72390523
24MP0008995_early_reproductive_senescence1.69819181
25MP0005645_abnormal_hypothalamus_physiol1.68132667
26MP0003186_abnormal_redox_activity1.67773918
27MP0002693_abnormal_pancreas_physiology1.66418109
28MP0003787_abnormal_imprinting1.65694342
29MP0010234_abnormal_vibrissa_follicle1.62000564
30MP0000427_abnormal_hair_cycle1.61250818
31MP0001666_abnormal_nutrient_absorption1.56737033
32MP0002277_abnormal_respiratory_mucosa1.56382182
33MP0010352_gastrointestinal_tract_polyps1.52708872
34MP0010094_abnormal_chromosome_stability1.50721114
35MP0001944_abnormal_pancreas_morphology1.45378586
36MP0002837_dystrophic_cardiac_calcinosis1.43879835
37MP0001873_stomach_inflammation1.43331958
38MP0002909_abnormal_adrenal_gland1.42719384
39MP0005395_other_phenotype1.42290848
40MP0006036_abnormal_mitochondrial_physio1.40451172
41MP0001501_abnormal_sleep_pattern1.36542123
42MP0002163_abnormal_gland_morphology1.36168374
43MP0002139_abnormal_hepatobiliary_system1.35625647
44MP0001485_abnormal_pinna_reflex1.35510741
45MP0001929_abnormal_gametogenesis1.33228757
46MP0008872_abnormal_physiological_respon1.33016123
47MP0009840_abnormal_foam_cell1.32887547
48MP0002938_white_spotting1.31432227
49MP0005551_abnormal_eye_electrophysiolog1.30123860
50MP0009697_abnormal_copulation1.29793710
51MP0005332_abnormal_amino_acid1.27960922
52MP0005636_abnormal_mineral_homeostasis1.27138545
53MP0003878_abnormal_ear_physiology1.24764338
54MP0005377_hearing/vestibular/ear_phenot1.24764338
55MP0005365_abnormal_bile_salt1.22275344
56MP0003123_paternal_imprinting1.21006877
57MP0001764_abnormal_homeostasis1.18992780
58MP0004957_abnormal_blastocyst_morpholog1.18049933
59MP0001756_abnormal_urination1.15330335
60MP0003077_abnormal_cell_cycle1.15198664
61MP0006035_abnormal_mitochondrial_morpho1.15094220
62MP0005075_abnormal_melanosome_morpholog1.14928610
63MP0006072_abnormal_retinal_apoptosis1.14762587
64MP0005084_abnormal_gallbladder_morpholo1.13606244
65MP0003111_abnormal_nucleus_morphology1.12439908
66MP0002160_abnormal_reproductive_system1.11942228
67MP0005310_abnormal_salivary_gland1.11540243
68MP0008875_abnormal_xenobiotic_pharmacok1.10307085
69MP0004043_abnormal_pH_regulation1.10203179
70MP0003806_abnormal_nucleotide_metabolis1.09028319
71MP0002090_abnormal_vision1.06620820
72MP0001765_abnormal_ion_homeostasis1.06382263
73MP0010329_abnormal_lipoprotein_level1.02690699
74MP0005220_abnormal_exocrine_pancreas1.01103432
75MP0002138_abnormal_hepatobiliary_system1.00576921
76MP0000653_abnormal_sex_gland0.99602675
77MP0001188_hyperpigmentation0.99316786
78MP0003698_abnormal_male_reproductive0.98320424
79MP0004215_abnormal_myocardial_fiber0.96214839
80MP0001145_abnormal_male_reproductive0.94064076
81MP0004147_increased_porphyrin_level0.93948723
82MP0005253_abnormal_eye_physiology0.92851443
83MP0003868_abnormal_feces_composition0.90869382
84MP0002796_impaired_skin_barrier0.90849209
85MP0001529_abnormal_vocalization0.90737430
86MP0004264_abnormal_extraembryonic_tissu0.88000353
87MP0003656_abnormal_erythrocyte_physiolo0.87614635
88MP0002210_abnormal_sex_determination0.87470727
89MP0000538_abnormal_urinary_bladder0.86955995
90MP0002168_other_aberrant_phenotype0.84466209
91MP0005389_reproductive_system_phenotype0.84042420
92MP0003122_maternal_imprinting0.77927585
93MP0002078_abnormal_glucose_homeostasis0.75666746
94MP0000647_abnormal_sebaceous_gland0.74988399
95MP0000372_irregular_coat_pigmentation0.74884837
96MP0010678_abnormal_skin_adnexa0.74473813
97MP0004085_abnormal_heartbeat0.74187851
98MP0010307_abnormal_tumor_latency0.73889531
99MP0005085_abnormal_gallbladder_physiolo0.72644956
100MP0003953_abnormal_hormone_level0.71613547

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)3.40271593
2Hyperinsulinemic hypoglycemia (HP:0000825)3.32930139
3Vascular calcification (HP:0004934)3.28512322
4Breast carcinoma (HP:0003002)2.92005445
5Hypoglycemic coma (HP:0001325)2.88594654
6Intestinal atresia (HP:0011100)2.87802525
7Acute encephalopathy (HP:0006846)2.85659299
8Acute necrotizing encephalopathy (HP:0006965)2.82708870
9Abnormality of renal resorption (HP:0011038)2.81459913
10Progressive macrocephaly (HP:0004481)2.73614023
11Cardiovascular calcification (HP:0011915)2.67298125
12Abnormality of the pons (HP:0007361)2.66026773
13Hypoglycemic seizures (HP:0002173)2.48417150
14Increased CSF lactate (HP:0002490)2.47967068
15Abnormality of the labia minora (HP:0012880)2.44471302
16Abnormality of vitamin B metabolism (HP:0004340)2.42144389
17Type I transferrin isoform profile (HP:0003642)2.39910853
18Hyperphosphatemia (HP:0002905)2.39796506
19Mitochondrial inheritance (HP:0001427)2.37589671
20Severe visual impairment (HP:0001141)2.37288208
21Gaze-evoked nystagmus (HP:0000640)2.37002493
22Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36659555
23Chronic hepatic failure (HP:0100626)2.34222841
24Large for gestational age (HP:0001520)2.29196327
25Lipid accumulation in hepatocytes (HP:0006561)2.27402884
26Methylmalonic acidemia (HP:0002912)2.25783004
27Abnormality of endocrine pancreas physiology (HP:0012093)2.25764557
28Abnormality of the pancreatic islet cells (HP:0006476)2.25764557
29Congenital stationary night blindness (HP:0007642)2.25084343
30Sparse eyelashes (HP:0000653)2.24838107
31Pancreatic islet-cell hyperplasia (HP:0004510)2.24172635
32Abnormal mitochondria in muscle tissue (HP:0008316)2.21599559
33Pancreatic cysts (HP:0001737)2.21550460
34Glycosuria (HP:0003076)2.20955045
35Abnormality of urine glucose concentration (HP:0011016)2.20955045
36Hypobetalipoproteinemia (HP:0003563)2.20755286
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20722044
38Abnormal protein N-linked glycosylation (HP:0012347)2.20722044
39Abnormal protein glycosylation (HP:0012346)2.20722044
40Abnormal glycosylation (HP:0012345)2.20722044
41Biliary tract neoplasm (HP:0100574)2.18075436
42Abnormal biliary tract morphology (HP:0012440)2.15939961
43Abnormality of the nasal septum (HP:0000419)2.14199837
44Renal Fanconi syndrome (HP:0001994)2.13016789
45Abnormality of the renal cortex (HP:0011035)2.11944651
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11810922
47Abnormality of methionine metabolism (HP:0010901)2.11253910
48Hyperglycinemia (HP:0002154)2.08865175
49Tongue fasciculations (HP:0001308)2.08116872
50Pancreatic fibrosis (HP:0100732)2.07659835
51Medial flaring of the eyebrow (HP:0010747)2.07056138
52Hyperglycemia (HP:0003074)2.05678477
53Increased hepatocellular lipid droplets (HP:0006565)2.03411455
54Ketoacidosis (HP:0001993)2.02364991
55Hepatic necrosis (HP:0002605)2.02246830
56Abnormal pancreas size (HP:0012094)2.01926496
57Steatorrhea (HP:0002570)2.01915252
58Generalized aminoaciduria (HP:0002909)1.99615908
59Cerebral edema (HP:0002181)1.97962406
60Hypolipoproteinemia (HP:0010981)1.97699536
61Hypoplasia of the pons (HP:0012110)1.96660273
62Abnormal rod and cone electroretinograms (HP:0008323)1.96358417
63Abnormality of renal excretion (HP:0011036)1.96174989
64Progressive inability to walk (HP:0002505)1.95816474
65True hermaphroditism (HP:0010459)1.95687962
66Increased CSF protein (HP:0002922)1.94978723
67Symptomatic seizures (HP:0011145)1.92404305
68Attenuation of retinal blood vessels (HP:0007843)1.91943416
69Abnormality of vitamin metabolism (HP:0100508)1.91736547
70Proximal tubulopathy (HP:0000114)1.91102989
71Congenital, generalized hypertrichosis (HP:0004540)1.90076675
72Lethargy (HP:0001254)1.88084549
73Palpitations (HP:0001962)1.87086720
74Urethral obstruction (HP:0000796)1.85702353
75Renal cortical cysts (HP:0000803)1.85548948
76Rhabdomyosarcoma (HP:0002859)1.84872831
77Median cleft lip (HP:0000161)1.84721769
78Intrahepatic cholestasis (HP:0001406)1.82641005
79Muscular hypotonia of the trunk (HP:0008936)1.82578971
80Hypokinesia (HP:0002375)1.82187611
81Aplasia/hypoplasia of the uterus (HP:0008684)1.81515093
82Popliteal pterygium (HP:0009756)1.79941207
83Volvulus (HP:0002580)1.79238239
84Duplicated collecting system (HP:0000081)1.79015448
85Hepatocellular necrosis (HP:0001404)1.78700033
86Facial diplegia (HP:0001349)1.78648610
87Congenital malformation of the right heart (HP:0011723)1.77312033
88Double outlet right ventricle (HP:0001719)1.77312033
89Abnormality of midbrain morphology (HP:0002418)1.76620481
90Molar tooth sign on MRI (HP:0002419)1.76620481
91Follicular hyperkeratosis (HP:0007502)1.75244766
92Aqueductal stenosis (HP:0002410)1.75062057
93Neoplasm of the adrenal gland (HP:0100631)1.74864437
94Sensory axonal neuropathy (HP:0003390)1.74560202
95Hypoplasia of the uterus (HP:0000013)1.74352080
96Right ventricular cardiomyopathy (HP:0011663)1.72171384
97Insulin-resistant diabetes mellitus (HP:0000831)1.69335470
98Type II lissencephaly (HP:0007260)1.69120095
99Abnormality of glycolysis (HP:0004366)1.67890258
100Enlarged penis (HP:0000040)1.67611998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.94813480
2BRSK23.66771798
3FRK3.40457331
4EPHA23.25213871
5EIF2AK33.19056046
6TRIM282.67512071
7MAP3K122.67187289
8WEE12.65000229
9GRK12.64487097
10STK392.61702783
11TSSK62.61594507
12MKNK22.54623187
13OXSR12.26875152
14STK38L2.26502042
15BUB12.05448539
16NUAK11.83281077
17ACVR1B1.78451455
18ZAK1.65928749
19BMPR1B1.65132972
20PAK31.55263721
21TTK1.53034164
22MAP4K21.48903818
23FER1.45257296
24STK31.43021560
25PBK1.42203442
26MKNK11.37801108
27BRSK11.37187981
28PLK31.36137651
29WNK31.35594476
30AKT31.30940146
31PRKCI1.21310130
32INSRR1.20876329
33ERBB31.18833287
34SRPK11.18581347
35PLK41.17173164
36SIK31.16210365
37ADRBK21.09420074
38PDK21.03165356
39PINK10.99554765
40STK100.99169193
41BCR0.96654262
42STK240.96372030
43TNIK0.95976431
44VRK20.94064037
45EIF2AK10.90244733
46MAP3K20.89877412
47BMPR20.86388198
48WNK40.83959633
49MAP3K40.79914643
50PRKCE0.75877589
51FGFR20.74680913
52CASK0.71779495
53NME10.71603143
54PLK10.70724574
55LATS10.70433526
56PLK20.66574960
57VRK10.66403031
58IKBKB0.66046160
59TAF10.60165091
60EIF2AK20.59937736
61NLK0.56359453
62NEK10.49046347
63PNCK0.48555070
64FGFR10.47802781
65PRKCG0.46959251
66TRPM70.46713756
67CAMK1G0.45005506
68PHKG10.44032705
69PHKG20.44032705
70BRD40.43937582
71CAMK1D0.43773890
72CSNK1G10.42432226
73MYLK0.41317119
74STK40.37204115
75CHEK10.36971624
76ABL20.36021452
77MAP3K30.33775754
78MAP2K10.33499235
79ATM0.33330657
80CSNK1E0.32971742
81MAP2K60.31543091
82CSNK1A10.27501498
83MELK0.27130032
84CSNK2A20.27042568
85STK380.27042144
86CSNK2A10.26469048
87NEK60.25531866
88PIK3CG0.24741817
89STK160.24716754
90IRAK10.23423961
91PRKAA20.23018035
92PTK2B0.22003441
93DAPK10.21304427
94CAMK2D0.20678050
95ADRBK10.19680168
96FGFR30.18353447
97ALK0.17583440
98CSNK1G30.14778290
99IGF1R0.14478001
100PRKACB0.13995404

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.87660596
2Proteasome_Homo sapiens_hsa030503.36706245
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.28029941
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.80226101
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60427788
6Vitamin B6 metabolism_Homo sapiens_hsa007502.48725060
7Sulfur metabolism_Homo sapiens_hsa009202.40377767
8Selenocompound metabolism_Homo sapiens_hsa004502.40148044
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27730961
10RNA polymerase_Homo sapiens_hsa030202.26010162
11Butanoate metabolism_Homo sapiens_hsa006502.20856605
12Non-homologous end-joining_Homo sapiens_hsa034502.08796026
13Propanoate metabolism_Homo sapiens_hsa006401.96231080
14Oxidative phosphorylation_Homo sapiens_hsa001901.84917137
15One carbon pool by folate_Homo sapiens_hsa006701.83258512
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75504356
17RNA degradation_Homo sapiens_hsa030181.74617564
18Circadian rhythm_Homo sapiens_hsa047101.69218126
19RNA transport_Homo sapiens_hsa030131.65925960
20Fatty acid elongation_Homo sapiens_hsa000621.63283434
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62994177
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60069073
23Sphingolipid metabolism_Homo sapiens_hsa006001.56239210
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52601857
25Phototransduction_Homo sapiens_hsa047441.38704361
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33259327
27Folate biosynthesis_Homo sapiens_hsa007901.32733494
28Steroid biosynthesis_Homo sapiens_hsa001001.32613425
29Basal transcription factors_Homo sapiens_hsa030221.30281845
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30034501
31Glutathione metabolism_Homo sapiens_hsa004801.29129123
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27949055
33Parkinsons disease_Homo sapiens_hsa050121.22361878
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.22324390
35Vitamin digestion and absorption_Homo sapiens_hsa049771.22131131
36Homologous recombination_Homo sapiens_hsa034401.21931032
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20062795
38Caffeine metabolism_Homo sapiens_hsa002321.16319180
39Mismatch repair_Homo sapiens_hsa034301.15888179
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.11148448
41Collecting duct acid secretion_Homo sapiens_hsa049661.09467364
42Peroxisome_Homo sapiens_hsa041461.08686618
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05281857
44Ether lipid metabolism_Homo sapiens_hsa005651.01839556
45Nitrogen metabolism_Homo sapiens_hsa009101.01224563
46Purine metabolism_Homo sapiens_hsa002300.99237168
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96528652
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94342062
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93897989
50Huntingtons disease_Homo sapiens_hsa050160.93733359
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92746648
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91939646
53Linoleic acid metabolism_Homo sapiens_hsa005910.91898504
54Fat digestion and absorption_Homo sapiens_hsa049750.91874012
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88817028
56Fanconi anemia pathway_Homo sapiens_hsa034600.87771760
57Retinol metabolism_Homo sapiens_hsa008300.87455858
58Metabolic pathways_Homo sapiens_hsa011000.86034202
59Pyrimidine metabolism_Homo sapiens_hsa002400.85695831
60Tryptophan metabolism_Homo sapiens_hsa003800.82206400
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81650150
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81312465
63beta-Alanine metabolism_Homo sapiens_hsa004100.81167165
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79691079
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74312378
66Chemical carcinogenesis_Homo sapiens_hsa052040.73747406
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73507485
68Oocyte meiosis_Homo sapiens_hsa041140.71566775
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69862676
70Arginine and proline metabolism_Homo sapiens_hsa003300.66685943
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64637056
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64603143
73Mineral absorption_Homo sapiens_hsa049780.63287113
74Alzheimers disease_Homo sapiens_hsa050100.61970884
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.58404449
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56820151
77Nucleotide excision repair_Homo sapiens_hsa034200.56380754
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55212248
79p53 signaling pathway_Homo sapiens_hsa041150.53331517
80Sulfur relay system_Homo sapiens_hsa041220.53175993
81Tight junction_Homo sapiens_hsa045300.53066270
82Fatty acid degradation_Homo sapiens_hsa000710.52871654
83Pyruvate metabolism_Homo sapiens_hsa006200.50770237
84Inositol phosphate metabolism_Homo sapiens_hsa005620.50622071
85Type I diabetes mellitus_Homo sapiens_hsa049400.50409304
86N-Glycan biosynthesis_Homo sapiens_hsa005100.48862978
87Fatty acid metabolism_Homo sapiens_hsa012120.47553697
88Spliceosome_Homo sapiens_hsa030400.47251587
89Legionellosis_Homo sapiens_hsa051340.47161187
90mRNA surveillance pathway_Homo sapiens_hsa030150.46568392
91Cell cycle_Homo sapiens_hsa041100.45527991
92Insulin secretion_Homo sapiens_hsa049110.44383108
93Starch and sucrose metabolism_Homo sapiens_hsa005000.42490210
94Vibrio cholerae infection_Homo sapiens_hsa051100.41703901
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.40327887
96Pancreatic secretion_Homo sapiens_hsa049720.36640533
97Arachidonic acid metabolism_Homo sapiens_hsa005900.35332001
98Base excision repair_Homo sapiens_hsa034100.34274193
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33770551
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32760350

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