ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	5.80021842
2	regulation of sarcomere organization (GO:0060297)	4.66456539
3	microtubule depolymerization (GO:0007019)	4.48834783
4	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	4.23152838
5	regulation of mitotic spindle checkpoint (GO:1903504)	4.23152838
6	cullin deneddylation (GO:0010388)	4.12396510
7	protein deneddylation (GO:0000338)	3.87662316
8	rRNA catabolic process (GO:0016075)	3.71288453
9	attachment of spindle microtubules to kinetochore (GO:0008608)	3.69634383
10	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.56547427
11	secondary heart field specification (GO:0003139)	3.54611963
12	heart field specification (GO:0003128)	3.54611963
13	negative regulation of DNA recombination (GO:0045910)	3.53102404
14	positive regulation of cell cycle checkpoint (GO:1901978)	3.44135610
15	histone H2A acetylation (GO:0043968)	3.38471973
16	protein K11-linked deubiquitination (GO:0035871)	3.32516514
17	microtubule anchoring (GO:0034453)	3.25586657
18	synapsis (GO:0007129)	3.22428986
19	tryptophan metabolic process (GO:0006568)	3.17015025
20	centriole replication (GO:0007099)	3.16919571
21	L-fucose catabolic process (GO:0042355)	3.13661630
22	fucose catabolic process (GO:0019317)	3.13661630
23	L-fucose metabolic process (GO:0042354)	3.13661630
24	acrosome reaction (GO:0007340)	3.05917687
25	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.05547860
26	response to pheromone (GO:0019236)	3.05504049
27	magnesium ion transport (GO:0015693)	3.03859626
28	positive regulation of mitochondrial fission (GO:0090141)	3.02952926
29	positive regulation of protein homodimerization activity (GO:0090073)	3.01295634
30	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.95238217
31	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.88945120
32	protein-cofactor linkage (GO:0018065)	2.83850476
33	mitochondrion distribution (GO:0048311)	2.81738846
34	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.80624118
35	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.76893070
36	microtubule polymerization or depolymerization (GO:0031109)	2.73984382
37	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.73432937
38	isotype switching (GO:0045190)	2.73432937
39	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.73432937
40	nuclear pore organization (GO:0006999)	2.70006835
41	protein complex biogenesis (GO:0070271)	2.68982333
42	protein localization to kinetochore (GO:0034501)	2.68182450
43	regulation of DNA endoreduplication (GO:0032875)	2.68037330
44	recombinational repair (GO:0000725)	2.65225077
45	double-strand break repair via homologous recombination (GO:0000724)	2.64469500
46	replication fork processing (GO:0031297)	2.64298147
47	piRNA metabolic process (GO:0034587)	2.63381866
48	inositol phosphate catabolic process (GO:0071545)	2.63117387
49	indolalkylamine metabolic process (GO:0006586)	2.62980692
50	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.61928278
51	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.61928278
52	NADH dehydrogenase complex assembly (GO:0010257)	2.61928278
53	regulation of Golgi to plasma membrane protein transport (GO:0042996)	2.61163909
54	DNA replication-dependent nucleosome assembly (GO:0006335)	2.60315154
55	DNA replication-dependent nucleosome organization (GO:0034723)	2.60315154
56	mitochondrial genome maintenance (GO:0000002)	2.59759911
57	regulation of mitochondrial fission (GO:0090140)	2.59413926
58	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.57521995
59	peptidyl-histidine modification (GO:0018202)	2.57459418
60	histone H2A monoubiquitination (GO:0035518)	2.53481777
61	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.52972807
62	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.52170143
63	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.52170143
64	CENP-A containing nucleosome assembly (GO:0034080)	2.51681181
65	regulation of centrosome duplication (GO:0010824)	2.51068399
66	histone mRNA catabolic process (GO:0071044)	2.50402952
67	mitochondrial respiratory chain complex assembly (GO:0033108)	2.48260859
68	serotonin metabolic process (GO:0042428)	2.48245360
69	DNA catabolic process, exonucleolytic (GO:0000738)	2.47633058
70	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.47311771
71	negative regulation of sister chromatid segregation (GO:0033046)	2.47311771
72	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.47311771
73	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.47311771
74	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.47311771
75	prenylation (GO:0097354)	2.46378497
76	protein prenylation (GO:0018342)	2.46378497
77	vesicle transport along microtubule (GO:0047496)	2.46346570
78	ribonucleoprotein complex disassembly (GO:0032988)	2.45881286
79	postreplication repair (GO:0006301)	2.45587861
80	mitotic spindle checkpoint (GO:0071174)	2.44665954
81	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.43393512
82	N-terminal protein amino acid acetylation (GO:0006474)	2.43117854
83	ncRNA catabolic process (GO:0034661)	2.42335273
84	tyrosine metabolic process (GO:0006570)	2.42236272
85	mitotic spindle assembly checkpoint (GO:0007094)	2.41256924
86	protein import into peroxisome matrix (GO:0016558)	2.40026218
87	regulation of meiosis I (GO:0060631)	2.39791282
88	non-recombinational repair (GO:0000726)	2.39549566
89	double-strand break repair via nonhomologous end joining (GO:0006303)	2.39549566
90	negative regulation of chromosome segregation (GO:0051985)	2.38625235
91	respiratory chain complex IV assembly (GO:0008535)	2.38538280
92	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.38433796
93	spindle assembly checkpoint (GO:0071173)	2.38256400
94	spindle checkpoint (GO:0031577)	2.37993625
95	protein localization to synapse (GO:0035418)	2.37800448
96	negative regulation of microtubule polymerization (GO:0031115)	2.37229148
97	sister chromatid cohesion (GO:0007062)	2.36705758
98	regulation of mitochondrial translation (GO:0070129)	2.36485969
99	regulation of centrosome cycle (GO:0046605)	2.36289640
100	chromatin remodeling at centromere (GO:0031055)	2.35365600

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.70545785
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.13809199
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.90934578
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.83576818
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.82196169
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.80877758
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.78732452
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.73278703
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.72410743
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.64870942
11	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.54756477
12	* EST1_17652178_ChIP-ChIP_JURKAT_Human	2.50030644
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.43561497
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42421554
15	FUS_26573619_Chip-Seq_HEK293_Human	2.40483993
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.34755964
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.31886045
18	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.28803789
19	EWS_26573619_Chip-Seq_HEK293_Human	2.24920970
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.22959294
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.15932288
22	VDR_23849224_ChIP-Seq_CD4+_Human	2.13567321
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.12327314
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.99920900
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94066832
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93989295
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84773846
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.82045572
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.82041082
30	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.78913938
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.77719977
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.74896477
33	P300_19829295_ChIP-Seq_ESCs_Human	1.72139461
34	* CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.71206319
35	* ETS1_20019798_ChIP-Seq_JURKAT_Human	1.67569374
36	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.63330367
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.61753716
38	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.56174230
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.56100467
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.54931269
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.49082204
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.45852910
43	VDR_22108803_ChIP-Seq_LS180_Human	1.43825388
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42625095
45	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.39384553
46	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39271637
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.38340410
48	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37517739
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.34482195
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34482195
51	DCP1A_22483619_ChIP-Seq_HELA_Human	1.33818631
52	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33751324
53	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31499567
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31088469
55	E2F7_22180533_ChIP-Seq_HELA_Human	1.30126382
56	CIITA_25753668_ChIP-Seq_RAJI_Human	1.29854175
57	STAT3_23295773_ChIP-Seq_U87_Human	1.29160872
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28367284
59	* MYC_18940864_ChIP-ChIP_HL60_Human	1.27763728
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21641821
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.20393723
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19877025
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18932864
64	TCF4_23295773_ChIP-Seq_U87_Human	1.18321541
65	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.18033909
66	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.17993010
67	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.16498853
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15510111
69	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.14570163
70	GABP_19822575_ChIP-Seq_HepG2_Human	1.13108855
71	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12647906
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11594873
73	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10543943
74	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.10512363
75	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.10387531
76	AR_25329375_ChIP-Seq_VCAP_Human	1.10011565
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09056537
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08202017
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06500667
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.05967698
81	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05967698
82	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.04471658
83	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.04451030
84	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.03935804
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00904293
86	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.99796132
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.98818094
88	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.97156129
89	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.95690678
90	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.95592280
91	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.94261229
92	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.93574221
93	RUNX2_22187159_ChIP-Seq_PCA_Human	0.93453666
94	KDM5A_27292631_Chip-Seq_BREAST_Human	0.93349163
95	P53_22387025_ChIP-Seq_ESCs_Mouse	0.91175509
96	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.90528901
97	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.90089854
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.89271241
99	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.87855365
100	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.87565230

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	4.29397016
2	MP0000569_abnormal_digit_pigmentation	3.90197930
3	MP0009697_abnormal_copulation	3.80831563
4	MP0008877_abnormal_DNA_methylation	3.74958529
5	MP0005171_absent_coat_pigmentation	3.12445154
6	MP0008058_abnormal_DNA_repair	2.98402164
7	MP0003718_maternal_effect	2.88129094
8	MP0003195_calcinosis	2.62948812
9	MP0010094_abnormal_chromosome_stability	2.60363104
10	MP0000372_irregular_coat_pigmentation	2.59982843
11	MP0001188_hyperpigmentation	2.45264687
12	MP0002102_abnormal_ear_morphology	2.17264390
13	MP0001529_abnormal_vocalization	2.02043604
14	MP0003787_abnormal_imprinting	1.99055668
15	MP0006035_abnormal_mitochondrial_morpho	1.96093288
16	MP0005645_abnormal_hypothalamus_physiol	1.79115607
17	MP0001501_abnormal_sleep_pattern	1.75511478
18	MP0006276_abnormal_autonomic_nervous	1.75254681
19	MP0005174_abnormal_tail_pigmentation	1.69483096
20	MP0001986_abnormal_taste_sensitivity	1.65528498
21	MP0003786_premature_aging	1.64095096
22	MP0003077_abnormal_cell_cycle	1.60755056
23	MP0006036_abnormal_mitochondrial_physio	1.55413123
24	MP0003111_abnormal_nucleus_morphology	1.54114185
25	MP0008007_abnormal_cellular_replicative	1.50535152
26	MP0003693_abnormal_embryo_hatching	1.48976534
27	MP0003221_abnormal_cardiomyocyte_apopto	1.48779782
28	MP0004142_abnormal_muscle_tone	1.46227311
29	MP0003646_muscle_fatigue	1.43560089
30	MP0004484_altered_response_of	1.42689268
31	MP0003121_genomic_imprinting	1.41344120
32	MP0008995_early_reproductive_senescence	1.33689007
33	MP0003880_abnormal_central_pattern	1.33457372
34	MP0000358_abnormal_cell_content/	1.33153051
35	MP0005423_abnormal_somatic_nervous	1.32451771
36	MP0004215_abnormal_myocardial_fiber	1.31348977
37	MP0001984_abnormal_olfaction	1.29535239
38	MP0002332_abnormal_exercise_endurance	1.28269727
39	MP0004957_abnormal_blastocyst_morpholog	1.26226458
40	MP0004147_increased_porphyrin_level	1.24424125
41	MP0000371_diluted_coat_color	1.23257538
42	MP0001929_abnormal_gametogenesis	1.22459084
43	MP0000427_abnormal_hair_cycle	1.22405253
44	MP0005551_abnormal_eye_electrophysiolog	1.22051429
45	MP0009745_abnormal_behavioral_response	1.20403372
46	MP0009046_muscle_twitch	1.18653637
47	MP0001968_abnormal_touch/_nociception	1.16942200
48	MP0005266_abnormal_metabolism	1.16660186
49	MP0002254_reproductive_system_inflammat	1.14508129
50	MP0000015_abnormal_ear_pigmentation	1.13053488
51	MP0003890_abnormal_embryonic-extraembry	1.11902107
52	MP0004924_abnormal_behavior	1.09853642
53	MP0005386_behavior/neurological_phenoty	1.09853642
54	MP0005253_abnormal_eye_physiology	1.06930156
55	MP0003950_abnormal_plasma_membrane	1.06365349
56	MP0002736_abnormal_nociception_after	1.06085698
57	MP0003567_abnormal_fetal_cardiomyocyte	1.01905151
58	MP0000751_myopathy	0.98977773
59	MP0002210_abnormal_sex_determination	0.97645983
60	MP0008932_abnormal_embryonic_tissue	0.95262109
61	MP0005084_abnormal_gallbladder_morpholo	0.94183068
62	MP0006072_abnormal_retinal_apoptosis	0.93045864
63	MP0002837_dystrophic_cardiac_calcinosis	0.92955820
64	MP0002272_abnormal_nervous_system	0.91372788
65	MP0005410_abnormal_fertilization	0.91045747
66	MP0005395_other_phenotype	0.90646245
67	MP0004085_abnormal_heartbeat	0.89392598
68	MP0003698_abnormal_male_reproductive	0.88866192
69	MP0008872_abnormal_physiological_respon	0.88161708
70	MP0004742_abnormal_vestibular_system	0.87018760
71	MP0002751_abnormal_autonomic_nervous	0.85828580
72	MP0003656_abnormal_erythrocyte_physiolo	0.85535285
73	MP0005083_abnormal_biliary_tract	0.83506899
74	MP0002127_abnormal_cardiovascular_syste	0.81770940
75	MP0001486_abnormal_startle_reflex	0.78329335
76	MP0001191_abnormal_skin_condition	0.77377181
77	MP0004036_abnormal_muscle_relaxation	0.77014971
78	MP0002095_abnormal_skin_pigmentation	0.76958026
79	MP0000653_abnormal_sex_gland	0.76187006
80	MP0004043_abnormal_pH_regulation	0.74359684
81	MP0002876_abnormal_thyroid_physiology	0.74192734
82	MP0002063_abnormal_learning/memory/cond	0.74103637
83	MP0001919_abnormal_reproductive_system	0.74058613
84	MP0004084_abnormal_cardiac_muscle	0.73915334
85	MP0000631_abnormal_neuroendocrine_gland	0.73185090
86	MP0004145_abnormal_muscle_electrophysio	0.70131634
87	MP0001119_abnormal_female_reproductive	0.67720886
88	MP0004811_abnormal_neuron_physiology	0.67317943
89	MP0002229_neurodegeneration	0.64175219
90	MP0002160_abnormal_reproductive_system	0.64154741
91	MP0003186_abnormal_redox_activity	0.64062465
92	MP0001177_atelectasis	0.63000898
93	MP0005384_cellular_phenotype	0.62862187
94	MP0005310_abnormal_salivary_gland	0.62356537
95	MP0002822_catalepsy	0.61903811
96	MP0002067_abnormal_sensory_capabilities	0.61633981
97	MP0001145_abnormal_male_reproductive	0.61471319
98	MP0005397_hematopoietic_system_phenotyp	0.61225828
99	MP0001545_abnormal_hematopoietic_system	0.61225828
100	MP0005389_reproductive_system_phenotype	0.60907321

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypothermia (HP:0002045)	3.45123375
2	Absent speech (HP:0001344)	3.30189927
3	Abnormality of chromosome stability (HP:0003220)	3.07998312
4	Ependymoma (HP:0002888)	3.06685376
5	Medial flaring of the eyebrow (HP:0010747)	2.99995226
6	Chromsome breakage (HP:0040012)	2.98372834
7	Spinal muscular atrophy (HP:0007269)	2.79214515
8	Gait imbalance (HP:0002141)	2.72491209
9	Nephrogenic diabetes insipidus (HP:0009806)	2.68781025
10	Hyperventilation (HP:0002883)	2.68499146
11	Hyperalaninemia (HP:0003348)	2.68293934
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.68293934
13	Abnormality of alanine metabolism (HP:0010916)	2.68293934
14	Congenital primary aphakia (HP:0007707)	2.65396799
15	Protruding tongue (HP:0010808)	2.59138577
16	Neonatal respiratory distress (HP:0002643)	2.54856787
17	Drooling (HP:0002307)	2.52977812
18	Microvesicular hepatic steatosis (HP:0001414)	2.50812579
19	Lissencephaly (HP:0001339)	2.40094414
20	Abnormality of the astrocytes (HP:0100707)	2.37833225
21	Astrocytoma (HP:0009592)	2.37833225
22	Inability to walk (HP:0002540)	2.37176636
23	Glioma (HP:0009733)	2.36290111
24	Pancreatic cysts (HP:0001737)	2.33123460
25	Sloping forehead (HP:0000340)	2.32427479
26	Excessive salivation (HP:0003781)	2.32018102
27	Cortical dysplasia (HP:0002539)	2.30503926
28	Chronic hepatic failure (HP:0100626)	2.29099334
29	Redundant skin (HP:0001582)	2.28220437
30	Renal cortical cysts (HP:0000803)	2.24545168
31	Type II lissencephaly (HP:0007260)	2.24447792
32	Bile duct proliferation (HP:0001408)	2.23597781
33	Abnormal biliary tract physiology (HP:0012439)	2.23597781
34	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.23425121
35	Fair hair (HP:0002286)	2.18295157
36	Medulloblastoma (HP:0002885)	2.16856374
37	Abnormality of the ileum (HP:0001549)	2.15392083
38	Pancreatic fibrosis (HP:0100732)	2.14398659
39	Meckel diverticulum (HP:0002245)	2.12180698
40	Poor coordination (HP:0002370)	2.11978824
41	Pendular nystagmus (HP:0012043)	2.10370861
42	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.09187111
43	Abnormality of midbrain morphology (HP:0002418)	2.09052411
44	Molar tooth sign on MRI (HP:0002419)	2.09052411
45	Dialeptic seizures (HP:0011146)	2.05623283
46	Neoplasm of the adrenal cortex (HP:0100641)	2.04063107
47	Truncal obesity (HP:0001956)	2.02895434
48	Brushfield spots (HP:0001088)	2.00736313
49	Genital tract atresia (HP:0001827)	2.00316896
50	Small hand (HP:0200055)	1.99808020
51	Stenosis of the external auditory canal (HP:0000402)	1.97950718
52	Acute necrotizing encephalopathy (HP:0006965)	1.97191754
53	Impaired vibration sensation in the lower limbs (HP:0002166)	1.95276730
54	Generalized myoclonic seizures (HP:0002123)	1.92761464
55	Acute encephalopathy (HP:0006846)	1.91824994
56	Bony spicule pigmentary retinopathy (HP:0007737)	1.89904450
57	Hypoplasia of the pons (HP:0012110)	1.88134540
58	Volvulus (HP:0002580)	1.88026690
59	Abnormality of the pons (HP:0007361)	1.87784719
60	Cerebellar dysplasia (HP:0007033)	1.86627420
61	Optic nerve hypoplasia (HP:0000609)	1.86433115
62	Thyroiditis (HP:0100646)	1.86225000
63	Progressive inability to walk (HP:0002505)	1.85719015
64	Vaginal atresia (HP:0000148)	1.84909880
65	Chronic diarrhea (HP:0002028)	1.84248141
66	Spastic tetraplegia (HP:0002510)	1.82427906
67	Progressive macrocephaly (HP:0004481)	1.81502240
68	Hypoplastic iliac wings (HP:0002866)	1.81478212
69	Urinary urgency (HP:0000012)	1.81323210
70	Abnormal mitochondria in muscle tissue (HP:0008316)	1.81260147
71	Abolished electroretinogram (ERG) (HP:0000550)	1.79714000
72	Abnormal hair whorl (HP:0010721)	1.78254438
73	Intellectual disability, progressive (HP:0006887)	1.77835699
74	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.77806125
75	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.77806125
76	Abnormality of the carotid arteries (HP:0005344)	1.76985714
77	Papillary thyroid carcinoma (HP:0002895)	1.74832406
78	Increased CSF lactate (HP:0002490)	1.74359924
79	Atonic seizures (HP:0010819)	1.74178754
80	Aplasia/Hypoplasia of the lens (HP:0008063)	1.74084553
81	Autoamputation (HP:0001218)	1.73293493
82	Narrow forehead (HP:0000341)	1.73274244
83	Impulsivity (HP:0100710)	1.72437512
84	Abnormality of the corticospinal tract (HP:0002492)	1.72224663
85	3-Methylglutaconic aciduria (HP:0003535)	1.71907817
86	Poikiloderma (HP:0001029)	1.69282961
87	Hypoplastic pelvis (HP:0008839)	1.67801722
88	Astigmatism (HP:0000483)	1.67777737
89	Congenital stationary night blindness (HP:0007642)	1.67048412
90	Attenuation of retinal blood vessels (HP:0007843)	1.66961226
91	Lipid accumulation in hepatocytes (HP:0006561)	1.66588721
92	Pachygyria (HP:0001302)	1.65913410
93	Impaired vibratory sensation (HP:0002495)	1.65823422
94	Broad-based gait (HP:0002136)	1.64593998
95	Retinal dysplasia (HP:0007973)	1.64482340
96	Postnatal growth retardation (HP:0008897)	1.64317917
97	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.63135865
98	Facial diplegia (HP:0001349)	1.63083634
99	Abnormality of the preputium (HP:0100587)	1.62811516
100	Renal Fanconi syndrome (HP:0001994)	1.62101556

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	3.65153342
2	MAPK13	3.36470293
3	FRK	3.32299292
4	SRPK1	3.13611640
5	EIF2AK3	2.74720290
6	MAP4K2	2.59870202
7	CCNB1	2.58399467
8	ERBB3	2.48967733
9	MAP3K4	2.27959581
10	ZAK	2.25632542
11	BRD4	2.09712728
12	WNK3	2.07303744
13	MARK1	1.88315183
14	CLK1	1.82418914
15	BCR	1.74184635
16	MAP2K7	1.70104803
17	AKT3	1.65245933
18	STK39	1.64539669
19	BRSK2	1.62297537
20	STK38L	1.60743388
21	OXSR1	1.56180010
22	CSNK1G3	1.47283764
23	UHMK1	1.39171573
24	BUB1	1.39069941
25	MKNK2	1.37871773
26	CSNK1G1	1.34612435
27	MST4	1.34606274
28	EIF2AK1	1.33934501
29	OBSCN	1.31838840
30	TAOK3	1.28360794
31	CAMK4	1.28227786
32	PAK3	1.24815920
33	WNK4	1.24243857
34	CSNK1G2	1.23061469
35	NEK1	1.21628579
36	PINK1	1.20627588
37	CSNK1A1L	1.19877692
38	ADRBK2	1.10090916
39	CASK	1.09669388
40	NUAK1	1.01893581
41	PLK3	0.94801815
42	TTK	0.91462707
43	RPS6KA4	0.88678736
44	ACVR1B	0.87459065
45	PLK1	0.87431907
46	CAMK1D	0.85931091
47	STK16	0.81875516
48	STK3	0.81533596
49	TSSK6	0.81395486
50	TXK	0.81362282
51	TEC	0.81165141
52	ERBB4	0.80945396
53	MKNK1	0.79317554
54	PRKCI	0.79111504
55	PKN1	0.77978242
56	NME1	0.77443103
57	MAP3K6	0.77043522
58	PLK4	0.76562134
59	MAP2K4	0.74974691
60	DYRK3	0.73926726
61	VRK1	0.73913731
62	ATM	0.73423708
63	ATR	0.70951820
64	MAP3K5	0.69891139
65	MINK1	0.69153659
66	PRKCE	0.65318547
67	BMPR1B	0.65165510
68	CAMKK2	0.61553255
69	SCYL2	0.61349616
70	GRK1	0.56425385
71	DYRK2	0.53667144
72	PRKCG	0.51202147
73	CDC7	0.50623138
74	CHEK2	0.47921006
75	LATS1	0.45362188
76	MARK3	0.44965978
77	SGK2	0.43986595
78	CSNK1A1	0.43591892
79	PBK	0.42763539
80	PIM1	0.42677854
81	PRKD3	0.42113980
82	TAOK1	0.41916159
83	MAPK4	0.41172284
84	ABL1	0.40955829
85	CDK1	0.39846370
86	CSNK1D	0.39436281
87	PRKAA1	0.39380414
88	CAMK2A	0.38744439
89	PRKACB	0.37648358
90	RPS6KA5	0.37406276
91	MAPK10	0.35738234
92	KSR1	0.35061364
93	FER	0.34549653
94	EIF2AK2	0.33984693
95	BLK	0.33160817
96	CHEK1	0.32809909
97	PRKCB	0.31650088
98	CDK2	0.30485314
99	CAMK2B	0.29715199
100	PLK2	0.28269725

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.92604421
2	Basal transcription factors_Homo sapiens_hsa03022	3.53683716
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.08913910
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.08877117
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.96964122
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.76090693
7	RNA polymerase_Homo sapiens_hsa03020	2.74487819
8	Homologous recombination_Homo sapiens_hsa03440	2.52399466
9	Protein export_Homo sapiens_hsa03060	2.42826800
10	RNA transport_Homo sapiens_hsa03013	2.03392210
11	Nicotine addiction_Homo sapiens_hsa05033	1.93980349
12	Propanoate metabolism_Homo sapiens_hsa00640	1.92066844
13	Mismatch repair_Homo sapiens_hsa03430	1.91009435
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.87038010
15	Collecting duct acid secretion_Homo sapiens_hsa04966	1.84390218
16	RNA degradation_Homo sapiens_hsa03018	1.78393475
17	Circadian rhythm_Homo sapiens_hsa04710	1.77922806
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.70964179
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.69046548
20	Peroxisome_Homo sapiens_hsa04146	1.66461469
21	DNA replication_Homo sapiens_hsa03030	1.58555718
22	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.57233332
23	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.51679799
24	Taste transduction_Homo sapiens_hsa04742	1.49839988
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.48263978
26	Sulfur metabolism_Homo sapiens_hsa00920	1.41005673
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.39842142
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34593447
29	Cell cycle_Homo sapiens_hsa04110	1.33448560
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.32381204
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31137887
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.29096965
33	Butanoate metabolism_Homo sapiens_hsa00650	1.20701006
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.20009594
35	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.18614112
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.18540209
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.16392318
38	Proteasome_Homo sapiens_hsa03050	1.13675470
39	Phototransduction_Homo sapiens_hsa04744	1.10893393
40	Oocyte meiosis_Homo sapiens_hsa04114	1.09398275
41	Spliceosome_Homo sapiens_hsa03040	1.06877734
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.04263374
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.02747884
44	Purine metabolism_Homo sapiens_hsa00230	0.95660653
45	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.93298716
46	Alcoholism_Homo sapiens_hsa05034	0.92315276
47	Lysine degradation_Homo sapiens_hsa00310	0.91314618
48	Parkinsons disease_Homo sapiens_hsa05012	0.88790523
49	Regulation of autophagy_Homo sapiens_hsa04140	0.86841878
50	Olfactory transduction_Homo sapiens_hsa04740	0.85817875
51	Oxidative phosphorylation_Homo sapiens_hsa00190	0.85032299
52	mRNA surveillance pathway_Homo sapiens_hsa03015	0.83994983
53	Sphingolipid metabolism_Homo sapiens_hsa00600	0.83699474
54	Glutamatergic synapse_Homo sapiens_hsa04724	0.78659236
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.78647943
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75949985
57	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.74453053
58	p53 signaling pathway_Homo sapiens_hsa04115	0.73845234
59	Sulfur relay system_Homo sapiens_hsa04122	0.72704510
60	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.71995523
61	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.71351309
62	Primary immunodeficiency_Homo sapiens_hsa05340	0.70818680
63	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.70670102
64	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70186016
65	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.69659411
66	Amphetamine addiction_Homo sapiens_hsa05031	0.66542675
67	GABAergic synapse_Homo sapiens_hsa04727	0.66440505
68	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.64384987
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.63351276
70	Linoleic acid metabolism_Homo sapiens_hsa00591	0.61897233
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.59166429
72	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.58248490
73	Metabolic pathways_Homo sapiens_hsa01100	0.57908904
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.57874615
75	Steroid biosynthesis_Homo sapiens_hsa00100	0.54651332
76	One carbon pool by folate_Homo sapiens_hsa00670	0.53561860
77	Huntingtons disease_Homo sapiens_hsa05016	0.50435179
78	Long-term depression_Homo sapiens_hsa04730	0.47635854
79	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.47357277
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43269624
81	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.42431867
82	Morphine addiction_Homo sapiens_hsa05032	0.42213864
83	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.42100191
84	Dopaminergic synapse_Homo sapiens_hsa04728	0.41950645
85	Serotonergic synapse_Homo sapiens_hsa04726	0.41258399
86	Circadian entrainment_Homo sapiens_hsa04713	0.40012807
87	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.38082577
88	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.36757174
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.36727616
90	Cocaine addiction_Homo sapiens_hsa05030	0.35503131
91	mTOR signaling pathway_Homo sapiens_hsa04150	0.32876894
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30950021
93	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.26835312
94	Vibrio cholerae infection_Homo sapiens_hsa05110	0.26262928
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.26058966
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.26041620
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.25936700
98	Melanoma_Homo sapiens_hsa05218	0.25248292
99	Arginine biosynthesis_Homo sapiens_hsa00220	0.24529987
100	Base excision repair_Homo sapiens_hsa03410	0.24507185

ZNF17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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