ZNF174

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with three Cys2-His2-type zinc fingers in the carboxy-terminus, a putative nuclear localization signal, and an amino-terminus SCAN box which forms homodimers. This protein is believed to function as a transcriptional repressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1iron-sulfur cluster assembly (GO:0016226)4.90516671
2metallo-sulfur cluster assembly (GO:0031163)4.90516671
3positive regulation of mitochondrial fission (GO:0090141)4.72333416
4ribosomal small subunit biogenesis (GO:0042274)4.61502121
5negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.51821381
6ribosomal small subunit assembly (GO:0000028)4.32745384
7mitochondrial fusion (GO:0008053)4.28674267
8rRNA modification (GO:0000154)4.02902077
9regulation of retinoic acid receptor signaling pathway (GO:0048385)3.93407897
10ribonucleoprotein complex biogenesis (GO:0022613)3.90200327
11pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.86332451
12rRNA methylation (GO:0031167)3.85512943
13ribosomal large subunit biogenesis (GO:0042273)3.81736932
14ribosome biogenesis (GO:0042254)3.81488262
15histone H2B ubiquitination (GO:0033523)3.78770190
16chaperone-mediated protein transport (GO:0072321)3.72836006
17base-excision repair, AP site formation (GO:0006285)3.70707386
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.58663649
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.54485927
20maturation of SSU-rRNA (GO:0030490)3.43778971
21de novo posttranslational protein folding (GO:0051084)3.41005173
22piRNA metabolic process (GO:0034587)3.40575145
23DNA integration (GO:0015074)3.40071017
24pyrimidine nucleotide catabolic process (GO:0006244)3.39400347
25poly(A)+ mRNA export from nucleus (GO:0016973)3.38929481
26negative regulation of Notch signaling pathway (GO:0045746)3.36027223
27autophagic vacuole assembly (GO:0000045)3.32871717
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30933489
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30933489
30regulation of mitochondrial fission (GO:0090140)3.29991029
31formation of translation preinitiation complex (GO:0001731)3.28401805
32proteasome assembly (GO:0043248)3.26232082
33polyamine biosynthetic process (GO:0006596)3.25190130
34mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.24774339
35polyamine metabolic process (GO:0006595)3.23110037
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19569493
37ubiquinone metabolic process (GO:0006743)3.18639973
38regulation of translation in response to stress (GO:0043555)3.18522745
39snRNA metabolic process (GO:0016073)3.18184173
40mitochondrial fission (GO:0000266)3.16920786
41viral transcription (GO:0019083)3.16217757
42negative regulation of translational initiation (GO:0045947)3.15929767
43pseudouridine synthesis (GO:0001522)3.15114149
44translational termination (GO:0006415)3.14084763
45de novo protein folding (GO:0006458)3.10819473
46dosage compensation (GO:0007549)3.09477849
47regulation of Golgi to plasma membrane protein transport (GO:0042996)3.08416221
48chaperone mediated protein folding requiring cofactor (GO:0051085)3.04611512
49transcription from mitochondrial promoter (GO:0006390)3.03431720
50snRNA processing (GO:0016180)3.03140286
51negative regulation of mRNA processing (GO:0050686)3.01366178
52L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.00911404
53mitochondrial RNA metabolic process (GO:0000959)3.00537745
54mitotic nuclear envelope reassembly (GO:0007084)3.00427217
55nuclear envelope reassembly (GO:0031468)3.00427217
56ubiquinone biosynthetic process (GO:0006744)2.99205361
57pyrimidine dimer repair (GO:0006290)2.98286670
58establishment of mitochondrion localization (GO:0051654)2.98140749
59cellular component biogenesis (GO:0044085)2.98076478
60translational initiation (GO:0006413)2.91772690
61positive regulation of protein homooligomerization (GO:0032464)2.88523727
62protein insertion into membrane (GO:0051205)2.87705435
63translational elongation (GO:0006414)2.85683682
64regulation of mitochondrial translation (GO:0070129)2.85487558
65granulocyte differentiation (GO:0030851)2.84976282
66tRNA methylation (GO:0030488)2.82483339
67protein targeting to mitochondrion (GO:0006626)2.81578816
68peroxisome fission (GO:0016559)2.80792297
69regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.80456308
70viral life cycle (GO:0019058)2.80320402
71establishment of integrated proviral latency (GO:0075713)2.78435141
72protein-DNA complex disassembly (GO:0032986)2.75279915
73nucleosome disassembly (GO:0006337)2.75279915
74ncRNA 3-end processing (GO:0043628)2.74396996
75virion assembly (GO:0019068)2.73412681
76RNA methylation (GO:0001510)2.69735079
77rRNA processing (GO:0006364)2.69594847
78positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.69140341
79positive regulation of catecholamine secretion (GO:0033605)2.68667669
80deoxyribonucleotide catabolic process (GO:0009264)2.67788332
81histone H2A acetylation (GO:0043968)2.67664269
82rRNA transcription (GO:0009303)2.66652729
83positive regulation of receptor biosynthetic process (GO:0010870)2.64946856
84DNA damage response, detection of DNA damage (GO:0042769)2.64037839
85negative regulation of mRNA metabolic process (GO:1903312)2.62367361
86viral protein processing (GO:0019082)2.62054422
87regulation of translational initiation (GO:0006446)2.61925430
88SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60843277
89peptidyl-histidine modification (GO:0018202)2.60455120
90protein localization to mitochondrion (GO:0070585)2.58798534
91mitochondrial calcium ion transport (GO:0006851)2.58316651
92heme biosynthetic process (GO:0006783)2.57880247
93mitochondrion transport along microtubule (GO:0047497)2.57352995
94establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.57352995
95rRNA metabolic process (GO:0016072)2.55567077
96spliceosomal snRNP assembly (GO:0000387)2.55566756
97ribosome assembly (GO:0042255)2.54191213
98termination of RNA polymerase II transcription (GO:0006369)2.53945003
99tRNA aminoacylation for protein translation (GO:0006418)2.53863967
100regulation of vacuole organization (GO:0044088)2.53787900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.96037447
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.64026439
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.38831175
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38616353
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29347825
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.28291542
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.19956041
8THAP11_20581084_ChIP-Seq_MESCs_Mouse3.05912795
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97942923
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85830094
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.76193546
12XRN2_22483619_ChIP-Seq_HELA_Human2.73614115
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70274848
14DCP1A_22483619_ChIP-Seq_HELA_Human2.65960825
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65676027
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64554994
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.60654140
18CIITA_25753668_ChIP-Seq_RAJI_Human2.35055184
19GABP_19822575_ChIP-Seq_HepG2_Human2.34887654
20CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.16679720
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15503333
22* FOXP3_21729870_ChIP-Seq_TREG_Human2.15447107
23ZNF263_19887448_ChIP-Seq_K562_Human2.08842119
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05464853
25TTF2_22483619_ChIP-Seq_HELA_Human2.04396820
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02977041
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.01656651
28ZFX_18555785_ChIP-Seq_MESCs_Mouse1.99772055
29VDR_23849224_ChIP-Seq_CD4+_Human1.98422985
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95720467
31KDM5A_27292631_Chip-Seq_BREAST_Human1.95300110
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95159051
33CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.91321086
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90333427
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88861622
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86531606
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86286449
38E2F7_22180533_ChIP-Seq_HELA_Human1.86282527
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.85575955
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82792565
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.80224684
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77623263
43BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.74633910
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73469036
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.71966175
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67166732
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66135153
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64364083
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63288353
50MYC_22102868_ChIP-Seq_BL_Human1.63273429
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61868685
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57090624
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56638127
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54176829
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53507687
56VDR_21846776_ChIP-Seq_THP-1_Human1.52328042
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50780682
58TFEB_21752829_ChIP-Seq_HELA_Human1.50482050
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49119025
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47313807
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45919028
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45002220
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.41683965
64* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.40925536
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29055843
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28808374
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28205782
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20214213
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19660338
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19150651
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16929536
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16260861
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14782371
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13942903
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12200606
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11544570
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08828116
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07839533
79CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06841407
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04997537
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04510653
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04443036
83TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03759767
84MYC_18940864_ChIP-ChIP_HL60_Human1.02645076
85MAF_26560356_Chip-Seq_TH2_Human1.01858802
86SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.01040610
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.00681926
88* FOXP1_21924763_ChIP-Seq_HESCs_Human0.99875460
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98851200
90P68_20966046_ChIP-Seq_HELA_Human0.97841888
91IRF1_19129219_ChIP-ChIP_H3396_Human0.97567600
92TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96729474
93EGR1_19374776_ChIP-ChIP_THP-1_Human0.93658375
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91134263
95CTCF_21964334_Chip-Seq_Bcells_Human0.89063411
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88216433
97PHF8_20622854_ChIP-Seq_HELA_Human0.87819203
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.86320607
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85257007
100UTX_26944678_Chip-Seq_JUKART_Human0.83910375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.21879003
2MP0003693_abnormal_embryo_hatching2.93485252
3MP0006292_abnormal_olfactory_placode2.90754848
4MP0008789_abnormal_olfactory_epithelium2.86612155
5MP0005394_taste/olfaction_phenotype2.84952399
6MP0005499_abnormal_olfactory_system2.84952399
7MP0001529_abnormal_vocalization2.83939015
8MP0003111_abnormal_nucleus_morphology2.49801663
9MP0003221_abnormal_cardiomyocyte_apopto2.49248551
10MP0003077_abnormal_cell_cycle2.41497618
11MP0008932_abnormal_embryonic_tissue2.35755132
12MP0005058_abnormal_lysosome_morphology2.23637211
13MP0004957_abnormal_blastocyst_morpholog2.14486461
14MP0008260_abnormal_autophagy2.14452322
15MP0006036_abnormal_mitochondrial_physio2.12275575
16MP0006035_abnormal_mitochondrial_morpho2.00248788
17MP0010094_abnormal_chromosome_stability1.97505978
18MP0004233_abnormal_muscle_weight1.96580340
19MP0008007_abnormal_cellular_replicative1.82623834
20MP0003122_maternal_imprinting1.80883109
21MP0001730_embryonic_growth_arrest1.79938578
22MP0009840_abnormal_foam_cell1.76427069
23MP0001986_abnormal_taste_sensitivity1.76258369
24MP0000750_abnormal_muscle_regeneration1.75899468
25MP0005084_abnormal_gallbladder_morpholo1.75355029
26MP0002653_abnormal_ependyma_morphology1.68325557
27MP0000049_abnormal_middle_ear1.67941060
28MP0003186_abnormal_redox_activity1.63895847
29MP0003385_abnormal_body_wall1.55813282
30MP0005451_abnormal_body_composition1.50272256
31MP0000313_abnormal_cell_death1.48824854
32MP0000465_gastrointestinal_hemorrhage1.45982961
33MP0003806_abnormal_nucleotide_metabolis1.45804781
34MP0000350_abnormal_cell_proliferation1.34944393
35MP0001672_abnormal_embryogenesis/_devel1.34389863
36MP0005380_embryogenesis_phenotype1.34389863
37MP0000358_abnormal_cell_content/1.32352303
38MP0002132_abnormal_respiratory_system1.31701600
39MP0003984_embryonic_growth_retardation1.29664505
40MP0002080_prenatal_lethality1.29596806
41MP0002837_dystrophic_cardiac_calcinosis1.28179482
42MP0000681_abnormal_thyroid_gland1.28070669
43MP0001188_hyperpigmentation1.27493170
44MP0002088_abnormal_embryonic_growth/wei1.25818278
45MP0000490_abnormal_crypts_of1.23034643
46MP0001697_abnormal_embryo_size1.21502682
47MP0002160_abnormal_reproductive_system1.21000872
48MP0001764_abnormal_homeostasis1.19761616
49MP0005075_abnormal_melanosome_morpholog1.12370285
50MP0005646_abnormal_pituitary_gland1.12270054
51MP0000631_abnormal_neuroendocrine_gland1.11018262
52MP0002127_abnormal_cardiovascular_syste1.09905537
53MP0002233_abnormal_nose_morphology1.07142406
54MP0000749_muscle_degeneration1.05560395
55MP0004197_abnormal_fetal_growth/weight/1.04452409
56MP0002249_abnormal_larynx_morphology1.04388054
57MP0001929_abnormal_gametogenesis1.03676604
58MP0003315_abnormal_perineum_morphology1.02617236
59MP0000759_abnormal_skeletal_muscle1.01230699
60MP0006276_abnormal_autonomic_nervous1.00160132
61MP0002102_abnormal_ear_morphology0.97462194
62MP0002277_abnormal_respiratory_mucosa0.95680610
63MP0001727_abnormal_embryo_implantation0.95542639
64MP0002210_abnormal_sex_determination0.95459118
65MP0000703_abnormal_thymus_morphology0.94390579
66MP0002751_abnormal_autonomic_nervous0.94101295
67MP0002722_abnormal_immune_system0.92226118
68MP0000751_myopathy0.92186234
69MP0002269_muscular_atrophy0.92174227
70MP0003172_abnormal_lysosome_physiology0.89474404
71MP0000689_abnormal_spleen_morphology0.89375399
72MP0001145_abnormal_male_reproductive0.88482362
73MP0003786_premature_aging0.88183588
74MP0003121_genomic_imprinting0.86128798
75MP0002396_abnormal_hematopoietic_system0.85978375
76MP0002085_abnormal_embryonic_tissue0.85810940
77MP0002084_abnormal_developmental_patter0.84967721
78MP0002177_abnormal_outer_ear0.82854902
79MP0003718_maternal_effect0.82063283
80MP0002398_abnormal_bone_marrow0.81388711
81MP0009697_abnormal_copulation0.79008697
82MP0000653_abnormal_sex_gland0.77743697
83MP0005319_abnormal_enzyme/_coenzyme0.77724582
84MP0004133_heterotaxia0.77249852
85MP0005423_abnormal_somatic_nervous0.76774224
86MP0000678_abnormal_parathyroid_gland0.76764208
87MP0008961_abnormal_basal_metabolism0.76763489
88MP0006072_abnormal_retinal_apoptosis0.76387262
89MP0001545_abnormal_hematopoietic_system0.76121855
90MP0005397_hematopoietic_system_phenotyp0.76121855
91MP0002019_abnormal_tumor_incidence0.76065382
92MP0005248_abnormal_Harderian_gland0.75732112
93MP0005220_abnormal_exocrine_pancreas0.75639786
94MP0003567_abnormal_fetal_cardiomyocyte0.74739978
95MP0003828_pulmonary_edema0.73880062
96MP0002086_abnormal_extraembryonic_tissu0.73802580
97MP0003698_abnormal_male_reproductive0.73060696
98MP0002822_catalepsy0.71906278
99MP0003656_abnormal_erythrocyte_physiolo0.71897741
100MP0001849_ear_inflammation0.71627612

Predicted human phenotypes

RankGene SetZ-score
1Ragged-red muscle fibers (HP:0003200)4.71691846
2Progressive muscle weakness (HP:0003323)4.49877140
3Decreased activity of mitochondrial respiratory chain (HP:0008972)4.07935407
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.07935407
5Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.05172087
6Cerebral hypomyelination (HP:0006808)3.92568222
7Microvesicular hepatic steatosis (HP:0001414)3.86605737
8Tubulointerstitial nephritis (HP:0001970)3.80943692
9Retinal dysplasia (HP:0007973)3.79114884
10Reduced antithrombin III activity (HP:0001976)3.63539440
11Increased intramyocellular lipid droplets (HP:0012240)3.32802982
12Increased muscle lipid content (HP:0009058)3.27132726
13Multiple enchondromatosis (HP:0005701)3.08230121
14Lipid accumulation in hepatocytes (HP:0006561)2.98962033
15Rhabdomyolysis (HP:0003201)2.83699149
16Premature ovarian failure (HP:0008209)2.81144210
17Cholecystitis (HP:0001082)2.75017010
18Abnormal gallbladder physiology (HP:0012438)2.75017010
19Cortical dysplasia (HP:0002539)2.75002113
20Abnormality of cells of the erythroid lineage (HP:0012130)2.67184266
21Increased hepatocellular lipid droplets (HP:0006565)2.66571555
22Abnormal number of erythroid precursors (HP:0012131)2.65659317
23CNS hypomyelination (HP:0003429)2.64940947
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57884291
25Progressive external ophthalmoplegia (HP:0000590)2.57300397
26Increased serum pyruvate (HP:0003542)2.50587524
27Abnormal hemoglobin (HP:0011902)2.44932574
28Abnormality of glycolysis (HP:0004366)2.43713303
29Abnormal protein glycosylation (HP:0012346)2.41170024
30Abnormal glycosylation (HP:0012345)2.41170024
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.41170024
32Abnormal protein N-linked glycosylation (HP:0012347)2.41170024
33Exercise-induced muscle cramps (HP:0003710)2.38214852
34Failure to thrive in infancy (HP:0001531)2.38038481
35Myoglobinuria (HP:0002913)2.35473354
36Reticulocytosis (HP:0001923)2.33263504
37Abnormal mitochondria in muscle tissue (HP:0008316)2.31050796
38Urinary urgency (HP:0000012)2.30756188
39Cholelithiasis (HP:0001081)2.29780830
40Pallor (HP:0000980)2.29023856
41Shoulder girdle muscle weakness (HP:0003547)2.28716594
42Abnormality of fatty-acid metabolism (HP:0004359)2.28376066
43Deep palmar crease (HP:0006191)2.25376340
44Type I transferrin isoform profile (HP:0003642)2.24061691
45Postnatal microcephaly (HP:0005484)2.23369187
46Septate vagina (HP:0001153)2.23201084
47Congenital primary aphakia (HP:0007707)2.22634215
48Abnormality of the anterior horn cell (HP:0006802)2.21765289
49Degeneration of anterior horn cells (HP:0002398)2.21765289
50Exercise intolerance (HP:0003546)2.21029508
51Diaphragmatic weakness (HP:0009113)2.20388299
52Delusions (HP:0000746)2.20255541
53Poor eye contact (HP:0000817)2.19741999
54Secondary amenorrhea (HP:0000869)2.19551572
55Abnormality of reticulocytes (HP:0004312)2.18311659
56Hypergonadotropic hypogonadism (HP:0000815)2.14634107
57Increased serum lactate (HP:0002151)2.14589813
58Exercise-induced myalgia (HP:0003738)2.13184941
59Hyperglycinemia (HP:0002154)2.12126595
60Gait imbalance (HP:0002141)2.10087396
61Abnormality of the columella (HP:0009929)2.09588475
62Sensorimotor neuropathy (HP:0007141)2.08673351
63Lactic acidosis (HP:0003128)2.07337217
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99292078
65Rimmed vacuoles (HP:0003805)1.97488431
66Abnormality of the umbilical cord (HP:0010881)1.95087816
67Abnormal gallbladder morphology (HP:0012437)1.94766337
68Nephrogenic diabetes insipidus (HP:0009806)1.94736031
69Peripheral hypomyelination (HP:0007182)1.94057888
70Broad distal phalanx of finger (HP:0009836)1.92290974
71Macrocytic anemia (HP:0001972)1.89454232
72Retinal atrophy (HP:0001105)1.89275235
73Brushfield spots (HP:0001088)1.89144446
74Increased CSF lactate (HP:0002490)1.88492695
75Concave nail (HP:0001598)1.88271637
76Abnormality of the musculature of the pelvis (HP:0001469)1.88245617
77Abnormality of the hip-girdle musculature (HP:0001445)1.88245617
78Pelvic girdle muscle weakness (HP:0003749)1.87877403
79Reticulocytopenia (HP:0001896)1.86746652
80Limb-girdle muscle atrophy (HP:0003797)1.85756417
81Gout (HP:0001997)1.83813274
82Prominent metopic ridge (HP:0005487)1.83661309
83Athetosis (HP:0002305)1.82787754
84High anterior hairline (HP:0009890)1.82490522
85Medial flaring of the eyebrow (HP:0010747)1.81418423
86Cleft eyelid (HP:0000625)1.81124046
87Thoracic kyphosis (HP:0002942)1.80984104
88Emotional lability (HP:0000712)1.80177964
89Abnormality of the gallbladder (HP:0005264)1.79492292
90Type II lissencephaly (HP:0007260)1.77657587
91Abnormality of the fetal cardiovascular system (HP:0010948)1.77034066
92Abnormal umbilical cord blood vessels (HP:0011403)1.77034066
93Single umbilical artery (HP:0001195)1.77034066
94Ankle clonus (HP:0011448)1.74865661
95Trismus (HP:0000211)1.72027867
96Decreased testicular size (HP:0008734)1.71687757
97Horseshoe kidney (HP:0000085)1.71231775
98Self-mutilation (HP:0000742)1.70853090
99Opisthotonus (HP:0002179)1.69227347
100Delayed myelination (HP:0012448)1.68514223

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.99563700
2TIE13.73698499
3NME23.63753133
4BCKDK3.46581440
5MAP2K73.37653735
6SRPK13.13619576
7TESK22.81934978
8PINK12.57576645
9NEK12.40823192
10DYRK31.98519831
11MAP3K41.97740052
12VRK21.82430798
13PIM21.81364387
14KSR21.73856725
15BUB11.67442209
16MAP3K111.60729138
17CDC71.60203395
18CDK191.58391647
19PAK61.58219394
20PBK1.52195667
21CCNB11.52156599
22TESK11.51203358
23STK161.49360463
24NEK21.47730315
25RAF11.41746942
26CSNK1G31.39877776
27GRK61.39469886
28RPS6KB21.38014957
29CSNK1A1L1.37447012
30MUSK1.37097606
31EIF2AK11.36631553
32DYRK1B1.34327922
33PRPF4B1.31225487
34TAOK21.21750340
35BRSK11.21093647
36AURKA1.15298457
37RPS6KA41.11280216
38MAP3K11.06529963
39IRAK21.02889355
40MARK31.01699510
41ERN11.00610582
42CSNK1G10.98486006
43MAP2K40.91807589
44CSNK1G20.91521042
45PRKD20.89982531
46MAP3K50.88935211
47AKT20.86926120
48SIK20.82369812
49CAMKK20.81445930
50CDK70.80343447
51CDK140.78595442
52UHMK10.76761716
53MATK0.76012292
54TSSK60.73082448
55EIF2AK30.72618785
56ATR0.70893096
57AURKB0.70439021
58RPS6KA50.69922224
59MAP2K30.64426131
60FES0.61921763
61DAPK30.61534377
62EEF2K0.60421724
63RPS6KB10.59976209
64SCYL20.59786182
65MAP4K10.59325398
66EPHB10.55986890
67EPHA30.54504571
68WNK30.51925394
69PLK10.49949363
70PAK10.49491736
71TRIB30.49313776
72VRK10.49056853
73CDK20.48902511
74RPS6KA10.48579136
75CSNK2A10.47544486
76CSNK2A20.47180324
77OBSCN0.46225734
78DYRK20.45783131
79CAMK40.44237480
80STK38L0.41989878
81KSR10.41958835
82PIM10.41521469
83CDK80.41334847
84CHEK10.41049163
85TAOK10.39023449
86SIK30.38622151
87RPS6KC10.38310689
88RPS6KL10.38310689
89CDK90.37724720
90TAOK30.36362698
91CDK11A0.35945871
92CHEK20.33205344
93CDK120.32950510
94CDK150.32599238
95BRAF0.32462171
96STK380.31907026
97RIPK40.31281953
98TBK10.31122016
99KDR0.30529004
100MAPK110.30125388

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.60380288
2Base excision repair_Homo sapiens_hsa034103.35799739
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07684488
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.92779815
5Spliceosome_Homo sapiens_hsa030402.76733740
6RNA transport_Homo sapiens_hsa030132.43646510
7RNA polymerase_Homo sapiens_hsa030202.33254945
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30040310
9Sulfur relay system_Homo sapiens_hsa041222.26393119
10DNA replication_Homo sapiens_hsa030302.19437421
11Regulation of autophagy_Homo sapiens_hsa041402.01154324
12Pyrimidine metabolism_Homo sapiens_hsa002401.85776906
13mRNA surveillance pathway_Homo sapiens_hsa030151.79743185
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78228298
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.76316736
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75990856
17Biosynthesis of amino acids_Homo sapiens_hsa012301.66937040
18Proteasome_Homo sapiens_hsa030501.59800750
19Fatty acid elongation_Homo sapiens_hsa000621.56926417
20Carbon metabolism_Homo sapiens_hsa012001.55982082
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55860050
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55083835
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.52122283
24Fanconi anemia pathway_Homo sapiens_hsa034601.45933867
25Parkinsons disease_Homo sapiens_hsa050121.45554272
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.45246518
27Non-homologous end-joining_Homo sapiens_hsa034501.42438873
28Basal transcription factors_Homo sapiens_hsa030221.41983032
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40049653
30Cell cycle_Homo sapiens_hsa041101.30107739
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27168022
32Pentose phosphate pathway_Homo sapiens_hsa000301.25632206
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23777286
34Folate biosynthesis_Homo sapiens_hsa007901.23581961
35Oxidative phosphorylation_Homo sapiens_hsa001901.20807502
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19579342
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18811551
38RNA degradation_Homo sapiens_hsa030181.16161052
39Pyruvate metabolism_Homo sapiens_hsa006201.15575481
40Purine metabolism_Homo sapiens_hsa002301.14377057
41Vibrio cholerae infection_Homo sapiens_hsa051101.12194448
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.09507482
43Fructose and mannose metabolism_Homo sapiens_hsa000511.05502271
44Mismatch repair_Homo sapiens_hsa034301.04875273
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02845452
46Steroid biosynthesis_Homo sapiens_hsa001001.00546332
47Selenocompound metabolism_Homo sapiens_hsa004500.96543862
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95523427
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91283538
50p53 signaling pathway_Homo sapiens_hsa041150.91080433
51Nucleotide excision repair_Homo sapiens_hsa034200.88840746
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88716032
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87910434
54Collecting duct acid secretion_Homo sapiens_hsa049660.87792973
55mTOR signaling pathway_Homo sapiens_hsa041500.84236507
56Epstein-Barr virus infection_Homo sapiens_hsa051690.83063995
57Acute myeloid leukemia_Homo sapiens_hsa052210.82191538
58Arginine and proline metabolism_Homo sapiens_hsa003300.82118427
59Peroxisome_Homo sapiens_hsa041460.80883781
60Oocyte meiosis_Homo sapiens_hsa041140.80208339
61Huntingtons disease_Homo sapiens_hsa050160.76193674
62AMPK signaling pathway_Homo sapiens_hsa041520.76068334
63Apoptosis_Homo sapiens_hsa042100.72716988
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69512372
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68849382
66Alcoholism_Homo sapiens_hsa050340.67677712
67Viral carcinogenesis_Homo sapiens_hsa052030.67597244
68Galactose metabolism_Homo sapiens_hsa000520.67341310
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67149394
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.66901750
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66823184
72One carbon pool by folate_Homo sapiens_hsa006700.65493495
73N-Glycan biosynthesis_Homo sapiens_hsa005100.65288800
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64649214
75Bladder cancer_Homo sapiens_hsa052190.64018925
76Metabolic pathways_Homo sapiens_hsa011000.62023707
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60596904
78Lysosome_Homo sapiens_hsa041420.60127954
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59683063
80Shigellosis_Homo sapiens_hsa051310.59447909
81Herpes simplex infection_Homo sapiens_hsa051680.57853950
82Phenylalanine metabolism_Homo sapiens_hsa003600.56648760
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55305333
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52625822
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49874942
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49860421
87beta-Alanine metabolism_Homo sapiens_hsa004100.48598353
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45682416
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45120093
90Pancreatic cancer_Homo sapiens_hsa052120.43910769
91Glutathione metabolism_Homo sapiens_hsa004800.43667002
92Propanoate metabolism_Homo sapiens_hsa006400.43661732
93Hepatitis B_Homo sapiens_hsa051610.41812566
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41627040
95Chronic myeloid leukemia_Homo sapiens_hsa052200.40342290
96Systemic lupus erythematosus_Homo sapiens_hsa053220.39531113
97Phagosome_Homo sapiens_hsa041450.38926585
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37216459
99Alzheimers disease_Homo sapiens_hsa050100.36700602
100Synaptic vesicle cycle_Homo sapiens_hsa047210.33276906

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