ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	heme transport (GO:0015886)	5.12877959
2	definitive hemopoiesis (GO:0060216)	4.40699519
3	erythrocyte development (GO:0048821)	4.29798933
4	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	4.15674649
5	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	4.15674649
6	artery development (GO:0060840)	4.00162138
7	regulation of telomere maintenance via telomerase (GO:0032210)	3.85559575
8	meiotic chromosome segregation (GO:0045132)	3.83006395
9	cellular ketone body metabolic process (GO:0046950)	3.77931640
10	iron ion import (GO:0097286)	3.73566371
11	nuclear pore complex assembly (GO:0051292)	3.59587644
12	synapsis (GO:0007129)	3.48610854
13	negative regulation of telomere maintenance (GO:0032205)	3.47933692
14	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.46648609
15	positive regulation of granulocyte differentiation (GO:0030854)	3.42092256
16	microtubule depolymerization (GO:0007019)	3.39311469
17	granulocyte differentiation (GO:0030851)	3.35215078
18	regulation of neurotransmitter uptake (GO:0051580)	3.33214247
19	regulation of DNA methylation (GO:0044030)	3.27585768
20	nuclear pore organization (GO:0006999)	3.27433094
21	ketone body metabolic process (GO:1902224)	3.26720028
22	nerve growth factor signaling pathway (GO:0038180)	3.26700942
23	iron coordination entity transport (GO:1901678)	3.26343834
24	embryonic hemopoiesis (GO:0035162)	3.24498803
25	erythrocyte maturation (GO:0043249)	3.24286134
26	protoporphyrinogen IX metabolic process (GO:0046501)	3.23923557
27	protein K48-linked deubiquitination (GO:0071108)	3.22618412
28	megakaryocyte development (GO:0035855)	3.22057666
29	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.19598155
30	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.19598155
31	myeloid cell development (GO:0061515)	3.17256509
32	regulation of interferon-beta biosynthetic process (GO:0045357)	3.10953865
33	gas transport (GO:0015669)	3.09077545
34	positive regulation of T-helper 1 type immune response (GO:0002827)	3.07491965
35	regulation of DNA damage checkpoint (GO:2000001)	3.07378381
36	protein K63-linked deubiquitination (GO:0070536)	3.05199260
37	telomere maintenance via telomerase (GO:0007004)	3.04838293
38	outer ear morphogenesis (GO:0042473)	3.04809209
39	oxygen transport (GO:0015671)	3.03516533
40	reciprocal meiotic recombination (GO:0007131)	3.02972226
41	reciprocal DNA recombination (GO:0035825)	3.02972226
42	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.01242426
43	monoubiquitinated protein deubiquitination (GO:0035520)	2.99724003
44	negative regulation of execution phase of apoptosis (GO:1900118)	2.95732007
45	male meiosis (GO:0007140)	2.95228815
46	DNA damage induced protein phosphorylation (GO:0006975)	2.92019606
47	protein K11-linked deubiquitination (GO:0035871)	2.91188732
48	pericardium development (GO:0060039)	2.88686173
49	regulation of centriole replication (GO:0046599)	2.86931888
50	fucose catabolic process (GO:0019317)	2.85691963
51	L-fucose metabolic process (GO:0042354)	2.85691963
52	L-fucose catabolic process (GO:0042355)	2.85691963
53	response to histamine (GO:0034776)	2.85360753
54	establishment of protein localization to Golgi (GO:0072600)	2.81539499
55	cellular response to ethanol (GO:0071361)	2.74615238
56	regulation of T-helper 1 cell differentiation (GO:0045625)	2.74540850
57	regulation of histone H3-K4 methylation (GO:0051569)	2.73785581
58	microtubule polymerization or depolymerization (GO:0031109)	2.72733131
59	regulation of memory T cell differentiation (GO:0043380)	2.72506435
60	intra-S DNA damage checkpoint (GO:0031573)	2.71884251
61	mRNA cleavage (GO:0006379)	2.71003641
62	hematopoietic stem cell differentiation (GO:0060218)	2.70917408
63	centriole replication (GO:0007099)	2.70495445
64	negative regulation of mast cell activation (GO:0033004)	2.68499499
65	musculoskeletal movement (GO:0050881)	2.66537875
66	multicellular organismal movement (GO:0050879)	2.66537875
67	cytoplasmic mRNA processing body assembly (GO:0033962)	2.66026995
68	signal peptide processing (GO:0006465)	2.64594725
69	protein targeting to Golgi (GO:0000042)	2.64361876
70	reflex (GO:0060004)	2.64044520
71	peptidyl-threonine dephosphorylation (GO:0035970)	2.62967902
72	negative regulation of DNA repair (GO:0045738)	2.61977682
73	pore complex assembly (GO:0046931)	2.58708567
74	negative regulation of histone methylation (GO:0031061)	2.57214022
75	sensory perception of smell (GO:0007608)	2.56996793
76	Golgi to endosome transport (GO:0006895)	2.56435422
77	recombinational repair (GO:0000725)	2.56261539
78	histone mRNA catabolic process (GO:0071044)	2.56075490
79	histone H3-K4 trimethylation (GO:0080182)	2.55981667
80	regulation of protein glycosylation (GO:0060049)	2.53951759
81	polyamine biosynthetic process (GO:0006596)	2.53871027
82	behavioral response to cocaine (GO:0048148)	2.53738657
83	mesodermal cell differentiation (GO:0048333)	2.52683366
84	double-strand break repair via homologous recombination (GO:0000724)	2.52230834
85	regulation of T-helper 1 type immune response (GO:0002825)	2.50192726
86	positive regulation of erythrocyte differentiation (GO:0045648)	2.49894849
87	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.49738219
88	DNA replication checkpoint (GO:0000076)	2.48178842
89	regulation of histone H3-K9 methylation (GO:0051570)	2.45880409
90	thrombin receptor signaling pathway (GO:0070493)	2.45282603
91	ether lipid metabolic process (GO:0046485)	2.44788873
92	synaptic transmission, dopaminergic (GO:0001963)	2.44619233
93	regulation of histone H3-K27 methylation (GO:0061085)	2.43560815
94	negative regulation of thymocyte apoptotic process (GO:0070244)	2.42487316
95	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.41801515
96	G-protein coupled receptor internalization (GO:0002031)	2.41451445
97	import into cell (GO:0098657)	2.38876724
98	organic cation transport (GO:0015695)	2.38279990
99	phosphatidylinositol phosphorylation (GO:0046854)	2.36971823
100	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.36860411

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	3.55677462
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.52065169
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.50144260
4	VDR_22108803_ChIP-Seq_LS180_Human	3.24424853
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.03919730
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.81913732
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.79466665
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.72176665
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.51418894
10	GATA1_19941826_ChIP-Seq_K562_Human	2.48785441
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.31301269
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.22467397
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.13497219
14	EWS_26573619_Chip-Seq_HEK293_Human	2.04434561
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.89118789
16	FUS_26573619_Chip-Seq_HEK293_Human	1.88920130
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.87238951
18	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.85873299
19	GATA2_19941826_ChIP-Seq_K562_Human	1.83335848
20	STAT3_23295773_ChIP-Seq_U87_Human	1.82352664
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.81735515
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.76125220
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.75878298
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.67596958
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.66254061
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.63198216
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.59252012
28	TCF4_23295773_ChIP-Seq_U87_Human	1.57991398
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.52709007
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49493149
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.49493149
32	* ELK1_19687146_ChIP-ChIP_HELA_Human	1.47915462
33	* E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.46133546
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.46033554
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.43257099
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40892125
37	P300_19829295_ChIP-Seq_ESCs_Human	1.40218058
38	SCL_19346495_ChIP-Seq_HPC-7_Human	1.38485792
39	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.36154401
40	TP53_16413492_ChIP-PET_HCT116_Human	1.36054818
41	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.35107880
42	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.33179246
43	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.33038768
44	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.32939333
45	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.27547776
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22904980
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.22147356
48	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21362017
49	JUN_21703547_ChIP-Seq_K562_Human	1.21300163
50	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21212632
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20099001
52	NFYB_21822215_ChIP-Seq_K562_Human	1.18230845
53	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17148414
54	* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.16351388
55	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15468789
56	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.14230143
57	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.14183615
58	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14025543
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.13870003
60	* CDX2_22108803_ChIP-Seq_LS180_Human	1.12667119
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12052715
62	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.11867121
63	GATA3_26560356_Chip-Seq_TH1_Human	1.11024064
64	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.10847575
65	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10847575
66	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.10799202
67	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.09927030
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09783709
69	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.07659464
70	TBL1_22424771_ChIP-Seq_293T_Human	1.07590249
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.07166843
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06498533
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05954812
74	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05235569
75	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.04528422
76	NFYA_21822215_ChIP-Seq_K562_Human	1.03992813
77	AR_25329375_ChIP-Seq_VCAP_Human	1.03921286
78	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.02380676
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02303307
80	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.01739732
81	ETV1_20927104_ChIP-Seq_GIST48_Human	1.01671582
82	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00915118
83	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00915118
84	P300_18555785_Chip-Seq_ESCs_Mouse	1.00786782
85	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.99939411
86	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.99815993
87	RUNX_20019798_ChIP-Seq_JUKART_Human	0.99771209
88	* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99636403
89	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.98845678
90	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98705643
91	PHF8_20622853_ChIP-Seq_HELA_Human	0.98552240
92	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98199036
93	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98160042
94	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.98033939
95	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.96966359
96	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.96465554
97	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.96100622
98	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96045624
99	RXR_22108803_ChIP-Seq_LS180_Human	0.95787915
100	BCAT_22108803_ChIP-Seq_LS180_Human	0.95372172

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	4.84143798
2	MP0005451_abnormal_body_composition	4.57238853
3	MP0004147_increased_porphyrin_level	4.51075674
4	MP0009697_abnormal_copulation	3.45397386
5	MP0003045_fibrosis	3.44136446
6	MP0008995_early_reproductive_senescence	3.38532625
7	MP0003656_abnormal_erythrocyte_physiolo	2.55111745
8	MP0001545_abnormal_hematopoietic_system	2.16785297
9	MP0005397_hematopoietic_system_phenotyp	2.16785297
10	MP0008058_abnormal_DNA_repair	2.10014508
11	MP0008877_abnormal_DNA_methylation	2.01680406
12	MP0003786_premature_aging	1.99216952
13	MP0008872_abnormal_physiological_respon	1.95762831
14	MP0002396_abnormal_hematopoietic_system	1.90493699
15	MP0009046_muscle_twitch	1.88665518
16	MP0008875_abnormal_xenobiotic_pharmacok	1.87599448
17	MP0010094_abnormal_chromosome_stability	1.79891799
18	MP0005410_abnormal_fertilization	1.78746699
19	MP0008775_abnormal_heart_ventricle	1.73903325
20	MP0003111_abnormal_nucleus_morphology	1.73386117
21	MP0010307_abnormal_tumor_latency	1.73205630
22	MP0004808_abnormal_hematopoietic_stem	1.72735212
23	MP0002168_other_aberrant_phenotype	1.68925171
24	MP0003195_calcinosis	1.63794420
25	MP0005187_abnormal_penis_morphology	1.59583795
26	MP0005083_abnormal_biliary_tract	1.57041118
27	MP0005671_abnormal_response_to	1.51999784
28	MP0004084_abnormal_cardiac_muscle	1.50907543
29	MP0003943_abnormal_hepatobiliary_system	1.40315932
30	MP0005464_abnormal_platelet_physiology	1.38959722
31	MP0001873_stomach_inflammation	1.37421601
32	MP0001790_abnormal_immune_system	1.34247155
33	MP0005387_immune_system_phenotype	1.34247155
34	MP0002398_abnormal_bone_marrow	1.26629710
35	MP0003890_abnormal_embryonic-extraembry	1.23100776
36	MP0005395_other_phenotype	1.21021440
37	MP0001929_abnormal_gametogenesis	1.16786123
38	MP0002095_abnormal_skin_pigmentation	1.15266467
39	MP0010352_gastrointestinal_tract_polyps	1.13258124
40	MP0005636_abnormal_mineral_homeostasis	1.13031668
41	MP0008007_abnormal_cellular_replicative	1.12910602
42	MP0009785_altered_susceptibility_to	1.12716656
43	MP0004145_abnormal_muscle_electrophysio	1.09562033
44	MP0004947_skin_inflammation	1.09268433
45	MP0002722_abnormal_immune_system	1.08709838
46	MP0004510_myositis	1.06201245
47	MP0000689_abnormal_spleen_morphology	1.04266427
48	MP0003763_abnormal_thymus_physiology	1.02084910
49	MP0008961_abnormal_basal_metabolism	1.01818607
50	MP0001835_abnormal_antigen_presentation	1.01361921
51	MP0006276_abnormal_autonomic_nervous	1.00169203
52	MP0004130_abnormal_muscle_cell	0.99483112
53	MP0008770_decreased_survivor_rate	0.98439262
54	MP0000703_abnormal_thymus_morphology	0.97341669
55	MP0003698_abnormal_male_reproductive	0.96514688
56	MP0004885_abnormal_endolymph	0.93305381
57	MP0004133_heterotaxia	0.92547219
58	MP0004215_abnormal_myocardial_fiber	0.90804432
59	MP0004036_abnormal_muscle_relaxation	0.89317411
60	MP0001800_abnormal_humoral_immune	0.88973341
61	MP0005647_abnormal_sex_gland	0.86463948
62	MP0005310_abnormal_salivary_gland	0.86324928
63	MP0000613_abnormal_salivary_gland	0.86094801
64	MP0002210_abnormal_sex_determination	0.85658366
65	MP0002429_abnormal_blood_cell	0.84129255
66	MP0004142_abnormal_muscle_tone	0.83174105
67	MP0000427_abnormal_hair_cycle	0.81692292
68	MP0005645_abnormal_hypothalamus_physiol	0.81402109
69	MP0002088_abnormal_embryonic_growth/wei	0.81152237
70	MP0000647_abnormal_sebaceous_gland	0.80391492
71	MP0000716_abnormal_immune_system	0.79912524
72	MP0009278_abnormal_bone_marrow	0.78121206
73	MP0003984_embryonic_growth_retardation	0.77857417
74	MP0000230_abnormal_systemic_arterial	0.77641231
75	MP0002723_abnormal_immune_serum	0.75905130
76	MP0003959_abnormal_lean_body	0.75884862
77	MP0002138_abnormal_hepatobiliary_system	0.75784942
78	MP0005266_abnormal_metabolism	0.75146663
79	MP0003300_gastrointestinal_ulcer	0.75144707
80	MP0002876_abnormal_thyroid_physiology	0.72928118
81	MP0001440_abnormal_grooming_behavior	0.72883507
82	MP0002420_abnormal_adaptive_immunity	0.72732882
83	MP0000653_abnormal_sex_gland	0.70131045
84	MP0002693_abnormal_pancreas_physiology	0.69851704
85	MP0002928_abnormal_bile_duct	0.69626813
86	MP0001819_abnormal_immune_cell	0.69216567
87	MP0002452_abnormal_antigen_presenting	0.69152866
88	MP0003718_maternal_effect	0.68321735
89	MP0003303_peritoneal_inflammation	0.67730354
90	MP0002006_tumorigenesis	0.67406940
91	MP0004134_abnormal_chest_morphology	0.67331790
92	MP0002009_preneoplasia	0.66964291
93	MP0001697_abnormal_embryo_size	0.66726704
94	MP0001672_abnormal_embryogenesis/_devel	0.66332904
95	MP0005380_embryogenesis_phenotype	0.66332904
96	MP0000313_abnormal_cell_death	0.65921025
97	MP0000678_abnormal_parathyroid_gland	0.65843634
98	MP0002102_abnormal_ear_morphology	0.65545191
99	MP0002084_abnormal_developmental_patter	0.64892071
100	MP0001986_abnormal_taste_sensitivity	0.64703299

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Birth length less than 3rd percentile (HP:0003561)	5.05554988
2	Hypochromic microcytic anemia (HP:0004840)	4.52602180
3	Chromsome breakage (HP:0040012)	3.90158122
4	Poikilocytosis (HP:0004447)	3.72671937
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.58296238
6	Duplicated collecting system (HP:0000081)	3.49488569
7	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.23662135
8	11 pairs of ribs (HP:0000878)	3.22685724
9	Chronic hepatic failure (HP:0100626)	3.19417656
10	Acanthocytosis (HP:0001927)	3.01360670
11	Acute myeloid leukemia (HP:0004808)	3.01274229
12	Pancreatic cysts (HP:0001737)	2.90981859
13	Abnormality of the renal collecting system (HP:0004742)	2.84560855
14	Aplastic anemia (HP:0001915)	2.74725602
15	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.61709482
16	Stomach cancer (HP:0012126)	2.61029448
17	Pancreatic fibrosis (HP:0100732)	2.59329226
18	Acute lymphatic leukemia (HP:0006721)	2.58750385
19	Microcytic anemia (HP:0001935)	2.58173627
20	Fair hair (HP:0002286)	2.56436604
21	Truncus arteriosus (HP:0001660)	2.49787512
22	Gaze-evoked nystagmus (HP:0000640)	2.47332963
23	Cystic liver disease (HP:0006706)	2.42243723
24	Abnormality of DNA repair (HP:0003254)	2.42233636
25	Abnormality of midbrain morphology (HP:0002418)	2.41003205
26	Molar tooth sign on MRI (HP:0002419)	2.41003205
27	Protruding tongue (HP:0010808)	2.39422598
28	Hypochromic anemia (HP:0001931)	2.38022696
29	Abnormality of alanine metabolism (HP:0010916)	2.36699317
30	Hyperalaninemia (HP:0003348)	2.36699317
31	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.36699317
32	Clubbing of toes (HP:0100760)	2.34519504
33	Progressive cerebellar ataxia (HP:0002073)	2.31988113
34	Breast hypoplasia (HP:0003187)	2.29261068
35	Hyperventilation (HP:0002883)	2.28123450
36	True hermaphroditism (HP:0010459)	2.23317977
37	Abnormality of T cell number (HP:0011839)	2.19857271
38	Bowel incontinence (HP:0002607)	2.14496630
39	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.13811139
40	Inability to walk (HP:0002540)	2.09838265
41	Duodenal stenosis (HP:0100867)	2.07865362
42	Small intestinal stenosis (HP:0012848)	2.07865362
43	Generalized hypopigmentation of hair (HP:0011358)	2.06849459
44	Autoimmune hemolytic anemia (HP:0001890)	2.06408659
45	Abnormality of B cell number (HP:0010975)	2.02792157
46	Abnormality of chromosome stability (HP:0003220)	2.02699633
47	Furrowed tongue (HP:0000221)	2.02101967
48	Neoplasm of the oral cavity (HP:0100649)	2.01999288
49	Attenuation of retinal blood vessels (HP:0007843)	2.01442639
50	Abnormality of the renal cortex (HP:0011035)	2.01280853
51	Large for gestational age (HP:0001520)	2.00638366
52	Global brain atrophy (HP:0002283)	1.99946542
53	Ectopic kidney (HP:0000086)	1.99206235
54	Abnormality of the labia minora (HP:0012880)	1.99115459
55	Autoimmune thrombocytopenia (HP:0001973)	1.97796116
56	Prolonged bleeding time (HP:0003010)	1.96653240
57	Tinnitus (HP:0000360)	1.93171612
58	Polycythemia (HP:0001901)	1.92645337
59	Abnormal large intestine physiology (HP:0012700)	1.92354055
60	Abnormal hair whorl (HP:0010721)	1.92077923
61	Cheilitis (HP:0100825)	1.91407341
62	Panhypogammaglobulinemia (HP:0003139)	1.89981401
63	Intestinal atresia (HP:0011100)	1.87203641
64	Febrile seizures (HP:0002373)	1.87032164
65	T lymphocytopenia (HP:0005403)	1.86379444
66	Abnormality of T cells (HP:0002843)	1.86369199
67	Hypoplastic labia majora (HP:0000059)	1.85834179
68	Meckel diverticulum (HP:0002245)	1.84982278
69	Unilateral renal agenesis (HP:0000122)	1.84150749
70	Missing ribs (HP:0000921)	1.81672594
71	Slender long bone (HP:0003100)	1.81573534
72	Abnormality of the duodenum (HP:0002246)	1.81489297
73	Thyroid carcinoma (HP:0002890)	1.81467555
74	Patellar aplasia (HP:0006443)	1.81403961
75	Oral leukoplakia (HP:0002745)	1.80893552
76	Abnormality of cochlea (HP:0000375)	1.80802849
77	Medial flaring of the eyebrow (HP:0010747)	1.80360414
78	Abnormal biliary tract physiology (HP:0012439)	1.79377765
79	Bile duct proliferation (HP:0001408)	1.79377765
80	Flat face (HP:0012368)	1.79344393
81	Radial bowing (HP:0002986)	1.75324065
82	Congenital primary aphakia (HP:0007707)	1.75128388
83	Short nail (HP:0001799)	1.74681736
84	Nephronophthisis (HP:0000090)	1.74097557
85	Myelodysplasia (HP:0002863)	1.73835245
86	Genetic anticipation (HP:0003743)	1.73030637
87	Abnormality of the ileum (HP:0001549)	1.72369242
88	Nephrogenic diabetes insipidus (HP:0009806)	1.72052717
89	Constricted visual fields (HP:0001133)	1.72038009
90	Abnormality of the renal medulla (HP:0100957)	1.71947555
91	Hypoproteinemia (HP:0003075)	1.71221636
92	Abnormality of T cell physiology (HP:0011840)	1.71107379
93	Congenital stationary night blindness (HP:0007642)	1.70808885
94	Abnormality of the labia majora (HP:0012881)	1.69145961
95	Gait imbalance (HP:0002141)	1.67919447
96	Paralysis (HP:0003470)	1.67509646
97	Sloping forehead (HP:0000340)	1.67198044
98	Hyperbilirubinemia (HP:0002904)	1.66877514
99	Morphological abnormality of the inner ear (HP:0011390)	1.66872325
100	Papillary thyroid carcinoma (HP:0002895)	1.66368830

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.73465253
2	RIPK4	3.60124202
3	FRK	2.97468703
4	BMPR1B	2.88993713
5	TXK	2.67018427
6	PIK3CG	2.42234506
7	ACVR1B	2.33475940
8	WNK4	2.31096424
9	NUAK1	2.29196879
10	STK38L	2.25846231
11	WNK1	2.25336629
12	BRSK2	2.14743100
13	TRPM7	2.08591218
14	KSR2	2.07104886
15	MST4	1.99343736
16	BMPR2	1.95090315
17	NTRK3	1.93378836
18	EIF2AK1	1.83463121
19	ADRBK2	1.82565285
20	PLK4	1.78546922
21	AKT3	1.71939605
22	STK3	1.70949850
23	BRD4	1.67254516
24	MAP3K2	1.61889966
25	CLK1	1.55846288
26	TLK1	1.53951788
27	DAPK2	1.45978323
28	ZAK	1.39929452
29	MAP3K4	1.38924523
30	RAF1	1.37729861
31	LATS1	1.29731219
32	NEK1	1.23877692
33	PTK2B	1.22275831
34	TEC	1.19131295
35	MKNK2	1.15711617
36	EIF2AK3	1.15557883
37	KSR1	1.09268392
38	TTK	1.06372156
39	SGK2	1.03801092
40	BMX	1.03721848
41	GRK1	1.00568644
42	OXSR1	0.98555676
43	SYK	0.97110547
44	TIE1	0.95904784
45	MAP4K1	0.95436684
46	YES1	0.91959033
47	CDK12	0.91213094
48	PINK1	0.89813345
49	MAP2K1	0.87155835
50	TNIK	0.86352741
51	TGFBR1	0.86091729
52	NEK2	0.84580800
53	ZAP70	0.80721743
54	MAP2K6	0.80061049
55	JAK2	0.78555619
56	STK24	0.75685351
57	CAMK1D	0.74987103
58	PLK3	0.73989223
59	MKNK1	0.72858534
60	STK39	0.72275520
61	CAMK1G	0.71638321
62	PAK3	0.69332422
63	STK38	0.68834636
64	BTK	0.64967938
65	ATR	0.64935084
66	INSRR	0.62246936
67	SGK3	0.62183304
68	SGK1	0.61256925
69	PRKCH	0.60161664
70	PRKAA1	0.59396895
71	ATM	0.59226856
72	NLK	0.58823869
73	PRKAA2	0.58479316
74	STK4	0.57933651
75	JAK3	0.57931943
76	MAP3K7	0.57498354
77	NEK9	0.55851003
78	JAK1	0.54792460
79	PIM1	0.54237018
80	WEE1	0.53628734
81	CHEK2	0.53214016
82	CAMKK2	0.52055533
83	PLK2	0.46896932
84	MATK	0.44065534
85	LCK	0.43750160
86	WNK3	0.41810713
87	TAF1	0.37874398
88	RET	0.36019768
89	MAP3K14	0.35881816
90	PNCK	0.34244560
91	PDGFRB	0.32645648
92	BLK	0.32114963
93	HCK	0.31384181
94	MAP3K5	0.30851460
95	PRKCQ	0.29709091
96	LYN	0.28541374
97	RPS6KA5	0.28285566
98	MAP2K3	0.26923786
99	IRAK1	0.26329886
100	MAP2K4	0.26078447

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	4.11498187
2	Caffeine metabolism_Homo sapiens_hsa00232	3.01134036
3	Homologous recombination_Homo sapiens_hsa03440	2.41489060
4	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.23837377
5	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.07716711
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.01633477
7	Olfactory transduction_Homo sapiens_hsa04740	1.98131204
8	Nitrogen metabolism_Homo sapiens_hsa00910	1.92729919
9	Basal transcription factors_Homo sapiens_hsa03022	1.87015166
10	Ether lipid metabolism_Homo sapiens_hsa00565	1.84483247
11	Primary immunodeficiency_Homo sapiens_hsa05340	1.84147607
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.83726776
13	One carbon pool by folate_Homo sapiens_hsa00670	1.74694541
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.60020342
15	ABC transporters_Homo sapiens_hsa02010	1.56244388
16	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.49851772
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.47832184
18	Mismatch repair_Homo sapiens_hsa03430	1.46205618
19	Butanoate metabolism_Homo sapiens_hsa00650	1.44063505
20	Platelet activation_Homo sapiens_hsa04611	1.38039843
21	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.33747828
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.31171282
23	Type II diabetes mellitus_Homo sapiens_hsa04930	1.27594107
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.26135944
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.23109317
26	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.20098775
27	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.18284571
28	Measles_Homo sapiens_hsa05162	1.17288304
29	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.16940956
30	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.14917531
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.14668528
32	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.04786977
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04502072
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.04152635
35	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.02450199
36	Protein export_Homo sapiens_hsa03060	1.01537029
37	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.99429034
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.98746747
39	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.98005662
40	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.96652364
41	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.96384286
42	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.95892750
43	Nucleotide excision repair_Homo sapiens_hsa03420	0.95865686
44	mRNA surveillance pathway_Homo sapiens_hsa03015	0.92060188
45	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.90062186
46	Taste transduction_Homo sapiens_hsa04742	0.89634793
47	Circadian rhythm_Homo sapiens_hsa04710	0.88745517
48	Phototransduction_Homo sapiens_hsa04744	0.87757032
49	RNA transport_Homo sapiens_hsa03013	0.85654551
50	RNA degradation_Homo sapiens_hsa03018	0.84276477
51	Morphine addiction_Homo sapiens_hsa05032	0.83578251
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.82397073
53	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.81081704
54	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.80869662
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.80497408
56	Long-term depression_Homo sapiens_hsa04730	0.80394014
57	Renal cell carcinoma_Homo sapiens_hsa05211	0.79250407
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.78472188
59	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.76945218
60	Prolactin signaling pathway_Homo sapiens_hsa04917	0.75482910
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75159713
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.74346897
63	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.71487314
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.69508459
65	Serotonergic synapse_Homo sapiens_hsa04726	0.67066619
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66767373
67	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.66741480
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.64859033
69	TNF signaling pathway_Homo sapiens_hsa04668	0.64685834
70	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.64677486
71	FoxO signaling pathway_Homo sapiens_hsa04068	0.63942960
72	MAPK signaling pathway_Homo sapiens_hsa04010	0.63289850
73	Calcium signaling pathway_Homo sapiens_hsa04020	0.60452537
74	Melanoma_Homo sapiens_hsa05218	0.59683190
75	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.56937031
76	ErbB signaling pathway_Homo sapiens_hsa04012	0.55395788
77	Insulin secretion_Homo sapiens_hsa04911	0.55130711
78	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.54536986
79	Non-small cell lung cancer_Homo sapiens_hsa05223	0.54378619
80	Nicotine addiction_Homo sapiens_hsa05033	0.54113377
81	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.53945669
82	Viral carcinogenesis_Homo sapiens_hsa05203	0.53020560
83	MicroRNAs in cancer_Homo sapiens_hsa05206	0.52948979
84	VEGF signaling pathway_Homo sapiens_hsa04370	0.52214058
85	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.51661600
86	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.50623949
87	p53 signaling pathway_Homo sapiens_hsa04115	0.46521409
88	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.45902213
89	Cell cycle_Homo sapiens_hsa04110	0.44551337
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44373201
91	Choline metabolism in cancer_Homo sapiens_hsa05231	0.44164353
92	Hepatitis B_Homo sapiens_hsa05161	0.43264057
93	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42787943
94	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.42144588
95	Chemokine signaling pathway_Homo sapiens_hsa04062	0.41615043
96	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.40930962
97	Acute myeloid leukemia_Homo sapiens_hsa05221	0.40880286
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39690803
99	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.39201529
100	GABAergic synapse_Homo sapiens_hsa04727	0.38722621

ZNF175

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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