ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	5.18343911
2	nonmotile primary cilium assembly (GO:0035058)	4.36079410
3	presynaptic membrane assembly (GO:0097105)	4.32416655
4	presynaptic membrane organization (GO:0097090)	4.31955423
5	nucleobase catabolic process (GO:0046113)	4.13119791
6	postsynaptic membrane organization (GO:0001941)	4.08270074
7	behavioral response to nicotine (GO:0035095)	3.94383105
8	positive regulation of mitochondrial fission (GO:0090141)	3.90340576
9	regulation of cilium movement (GO:0003352)	3.90117354
10	intraciliary transport (GO:0042073)	3.86421729
11	neuronal action potential propagation (GO:0019227)	3.81698691
12	establishment of mitochondrion localization (GO:0051654)	3.74698204
13	cornea development in camera-type eye (GO:0061303)	3.62623083
14	neuron cell-cell adhesion (GO:0007158)	3.53947819
15	epithelial cilium movement (GO:0003351)	3.52372844
16	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.45397690
17	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.43574196
18	mechanosensory behavior (GO:0007638)	3.37927274
19	piRNA metabolic process (GO:0034587)	3.32520772
20	synapsis (GO:0007129)	3.26552346
21	protein localization to synapse (GO:0035418)	3.18981585
22	glycerophospholipid catabolic process (GO:0046475)	3.18361901
23	cilium movement (GO:0003341)	3.16063811
24	retinal ganglion cell axon guidance (GO:0031290)	3.12462854
25	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.11807027
26	head development (GO:0060322)	3.11621957
27	cilium morphogenesis (GO:0060271)	3.11127142
28	response to pheromone (GO:0019236)	3.07903426
29	adaptation of signaling pathway (GO:0023058)	3.07517292
30	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.04981649
31	substrate-independent telencephalic tangential migration (GO:0021826)	3.04981649
32	protein polyglutamylation (GO:0018095)	3.04565502
33	axonal fasciculation (GO:0007413)	2.99763883
34	resolution of meiotic recombination intermediates (GO:0000712)	2.98203676
35	regulation of microtubule-based movement (GO:0060632)	2.96298889
36	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.96118170
37	mitochondrion transport along microtubule (GO:0047497)	2.96118170
38	cilium organization (GO:0044782)	2.95429385
39	auditory behavior (GO:0031223)	2.95375505
40	photoreceptor cell maintenance (GO:0045494)	2.93909241
41	synapse assembly (GO:0007416)	2.93799296
42	cilium assembly (GO:0042384)	2.92205267
43	platelet dense granule organization (GO:0060155)	2.89379676
44	ovulation cycle (GO:0042698)	2.89194850
45	regulation of feeding behavior (GO:0060259)	2.86155077
46	anterograde synaptic vesicle transport (GO:0048490)	2.85940091
47	gamma-aminobutyric acid transport (GO:0015812)	2.85917197
48	protein localization to cilium (GO:0061512)	2.84896809
49	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.84526646
50	axoneme assembly (GO:0035082)	2.84050018
51	cellular response to leptin stimulus (GO:0044320)	2.82834167
52	regulation of development, heterochronic (GO:0040034)	2.82821763
53	transmission of nerve impulse (GO:0019226)	2.79246455
54	somite development (GO:0061053)	2.78701196
55	C4-dicarboxylate transport (GO:0015740)	2.77721576
56	vocalization behavior (GO:0071625)	2.75212031
57	anterograde axon cargo transport (GO:0008089)	2.74250890
58	regulation of timing of cell differentiation (GO:0048505)	2.71365191
59	negative regulation of membrane potential (GO:0045837)	2.70798464
60	neuron recognition (GO:0008038)	2.70622525
61	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.70485991
62	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.70485991
63	olfactory bulb development (GO:0021772)	2.69337875
64	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.66354515
65	cullin deneddylation (GO:0010388)	2.64477919
66	DNA methylation involved in gamete generation (GO:0043046)	2.62822401
67	protein-cofactor linkage (GO:0018065)	2.61153567
68	dendritic spine morphogenesis (GO:0060997)	2.60281728
69	negative regulation of appetite (GO:0032099)	2.60239752
70	negative regulation of response to food (GO:0032096)	2.60239752
71	seminiferous tubule development (GO:0072520)	2.58817582
72	smoothened signaling pathway (GO:0007224)	2.58742983
73	striatum development (GO:0021756)	2.58213260
74	adult walking behavior (GO:0007628)	2.56186427
75	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.54122593
76	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.53807359
77	neurotransmitter-gated ion channel clustering (GO:0072578)	2.53750901
78	ubiquinone metabolic process (GO:0006743)	2.52566110
79	regulation of mitochondrial fission (GO:0090140)	2.51868209
80	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.49924003
81	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.49924003
82	NADH dehydrogenase complex assembly (GO:0010257)	2.49924003
83	startle response (GO:0001964)	2.49807663
84	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.48634949
85	negative regulation of DNA recombination (GO:0045910)	2.48376091
86	protein complex biogenesis (GO:0070271)	2.46788810
87	negative regulation of axon guidance (GO:1902668)	2.46699379
88	respiratory chain complex IV assembly (GO:0008535)	2.46040353
89	regulation of action potential (GO:0098900)	2.45390178
90	DNA double-strand break processing (GO:0000729)	2.44783021
91	histone H2A acetylation (GO:0043968)	2.44620624
92	hindbrain development (GO:0030902)	2.43457880
93	water-soluble vitamin biosynthetic process (GO:0042364)	2.43186669
94	limb development (GO:0060173)	2.40992262
95	appendage development (GO:0048736)	2.40992262
96	cholesterol biosynthetic process (GO:0006695)	2.40905537
97	regulation of collateral sprouting (GO:0048670)	2.40773318
98	glycosphingolipid biosynthetic process (GO:0006688)	2.39837069
99	photoreceptor cell development (GO:0042461)	2.39582351
100	neuron fate determination (GO:0048664)	2.38381073

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.29435102
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.38054011
3	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.25712137
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.03900190
5	VDR_22108803_ChIP-Seq_LS180_Human	3.03061781
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.95644100
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.93870264
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.52939023
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40072892
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.33491165
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.33034144
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.30681571
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.21519195
14	FUS_26573619_Chip-Seq_HEK293_Human	2.20382053
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.16556227
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13301023
17	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.10092083
18	EWS_26573619_Chip-Seq_HEK293_Human	2.00810970
19	IRF1_19129219_ChIP-ChIP_H3396_Human	2.00546192
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.00227670
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97310696
22	P300_19829295_ChIP-Seq_ESCs_Human	1.93034073
23	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.82572887
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.80464847
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.79758563
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.79614810
27	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.73893707
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.69581421
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.65304344
30	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.61452727
31	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57695106
32	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.57417844
33	REST_21632747_ChIP-Seq_MESCs_Mouse	1.55391256
34	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.51516400
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.50285298
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49833009
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49490625
38	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.48361344
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.47439781
40	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.45734246
41	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.44586234
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.43200444
43	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.41932675
44	STAT3_23295773_ChIP-Seq_U87_Human	1.36665993
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36049970
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.35461929
47	AR_25329375_ChIP-Seq_VCAP_Human	1.34025763
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.33731188
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32693124
50	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32451609
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.29966773
52	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27327524
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.26577996
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26275414
55	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25200859
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24908124
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.24908124
58	BCAT_22108803_ChIP-Seq_LS180_Human	1.24555793
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23979335
60	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.23126639
61	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.21890296
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21227992
63	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.20307744
64	* TCF4_23295773_ChIP-Seq_U87_Human	1.19213582
65	MYC_18940864_ChIP-ChIP_HL60_Human	1.17291839
66	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16559114
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16511378
68	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.16511378
69	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.15052184
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14000342
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13061607
72	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.11184008
73	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.09787236
74	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.07832242
75	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.07152149
76	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.06453757
77	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.04648594
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.04378858
79	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.04085725
80	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01050484
81	VDR_23849224_ChIP-Seq_CD4+_Human	0.98854321
82	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98832806
83	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98362042
84	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.98269752
85	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.97655331
86	AR_21572438_ChIP-Seq_LNCaP_Human	0.96764801
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94936485
88	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.94819909
89	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.93730573
90	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.93672202
91	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.93500433
92	JUN_21703547_ChIP-Seq_K562_Human	0.92389756
93	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.92374067
94	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.91717077
95	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.90853008
96	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.90631365
97	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90137273
98	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90137273
99	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.86595436
100	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.85813157

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.87806227
2	MP0003787_abnormal_imprinting	3.72424671
3	MP0003880_abnormal_central_pattern	3.29151296
4	MP0008789_abnormal_olfactory_epithelium	3.19308732
5	MP0006292_abnormal_olfactory_placode	3.09809333
6	MP0003122_maternal_imprinting	3.06896908
7	MP0002102_abnormal_ear_morphology	2.90755662
8	MP0005499_abnormal_olfactory_system	2.83618541
9	MP0005394_taste/olfaction_phenotype	2.83618541
10	MP0001529_abnormal_vocalization	2.43612339
11	MP0005423_abnormal_somatic_nervous	2.41811294
12	MP0001984_abnormal_olfaction	2.37581225
13	MP0003121_genomic_imprinting	2.35246966
14	MP0002638_abnormal_pupillary_reflex	2.16851681
15	MP0000778_abnormal_nervous_system	2.12566964
16	MP0006276_abnormal_autonomic_nervous	1.98366189
17	MP0002653_abnormal_ependyma_morphology	1.96082172
18	MP0006072_abnormal_retinal_apoptosis	1.93463498
19	MP0005551_abnormal_eye_electrophysiolog	1.90967121
20	MP0002938_white_spotting	1.87747301
21	MP0004133_heterotaxia	1.85844185
22	MP0002736_abnormal_nociception_after	1.82211650
23	MP0001968_abnormal_touch/_nociception	1.74729650
24	MP0004859_abnormal_synaptic_plasticity	1.73580353
25	MP0003136_yellow_coat_color	1.73136719
26	MP0001986_abnormal_taste_sensitivity	1.65772708
27	MP0003011_delayed_dark_adaptation	1.63056813
28	MP0005253_abnormal_eye_physiology	1.63007128
29	MP0002272_abnormal_nervous_system	1.61499986
30	MP0002822_catalepsy	1.54960797
31	MP0001486_abnormal_startle_reflex	1.53707513
32	MP0009745_abnormal_behavioral_response	1.51500988
33	MP0001293_anophthalmia	1.50678401
34	MP0004270_analgesia	1.45564127
35	MP0009046_muscle_twitch	1.43806819
36	MP0002557_abnormal_social/conspecific_i	1.41206144
37	MP0003635_abnormal_synaptic_transmissio	1.36820159
38	MP0002734_abnormal_mechanical_nocicepti	1.36610477
39	MP0008058_abnormal_DNA_repair	1.36455621
40	MP0002233_abnormal_nose_morphology	1.36119496
41	MP0000631_abnormal_neuroendocrine_gland	1.36099070
42	MP0000049_abnormal_middle_ear	1.35251883
43	MP0000955_abnormal_spinal_cord	1.32047634
44	MP0002572_abnormal_emotion/affect_behav	1.30761394
45	MP0002751_abnormal_autonomic_nervous	1.29918438
46	MP0002063_abnormal_learning/memory/cond	1.28543577
47	MP0002184_abnormal_innervation	1.26197764
48	MP0004142_abnormal_muscle_tone	1.26015715
49	MP0001485_abnormal_pinna_reflex	1.23237785
50	MP0001188_hyperpigmentation	1.22047351
51	MP0002837_dystrophic_cardiac_calcinosis	1.17071189
52	MP0002752_abnormal_somatic_nervous	1.15471161
53	MP0002064_seizures	1.14787023
54	MP0002234_abnormal_pharynx_morphology	1.14019989
55	MP0003890_abnormal_embryonic-extraembry	1.11132261
56	MP0002735_abnormal_chemical_nociception	1.10632617
57	MP0002882_abnormal_neuron_morphology	1.10378971
58	MP0005391_vision/eye_phenotype	1.09537078
59	MP0001970_abnormal_pain_threshold	1.08587471
60	MP0002067_abnormal_sensory_capabilities	1.03449678
61	MP0002733_abnormal_thermal_nociception	1.02860599
62	MP0000647_abnormal_sebaceous_gland	1.02285696
63	MP0005195_abnormal_posterior_eye	1.00911027
64	MP0001286_abnormal_eye_development	0.99271034
65	MP0003937_abnormal_limbs/digits/tail_de	0.97074115
66	MP0000427_abnormal_hair_cycle	0.95708515
67	MP0002210_abnormal_sex_determination	0.94855186
68	MP0002152_abnormal_brain_morphology	0.94501589
69	MP0000026_abnormal_inner_ear	0.94154761
70	MP0004811_abnormal_neuron_physiology	0.93486148
71	MP0005187_abnormal_penis_morphology	0.92323277
72	MP0003755_abnormal_palate_morphology	0.90471661
73	MP0003861_abnormal_nervous_system	0.89527625
74	MP0005645_abnormal_hypothalamus_physiol	0.89225568
75	MP0003119_abnormal_digestive_system	0.88530904
76	MP0001929_abnormal_gametogenesis	0.88295951
77	MP0004924_abnormal_behavior	0.86774364
78	MP0005386_behavior/neurological_phenoty	0.86774364
79	MP0003698_abnormal_male_reproductive	0.86634851
80	MP0000383_abnormal_hair_follicle	0.85697187
81	MP0001324_abnormal_eye_pigmentation	0.84903778
82	MP0009379_abnormal_foot_pigmentation	0.84618166
83	MP0001905_abnormal_dopamine_level	0.83992916
84	MP0003646_muscle_fatigue	0.80508153
85	MP0003718_maternal_effect	0.80415662
86	MP0003567_abnormal_fetal_cardiomyocyte	0.77414947
87	MP0003938_abnormal_ear_development	0.77327746
88	MP0000653_abnormal_sex_gland	0.76566680
89	MP0004742_abnormal_vestibular_system	0.76049317
90	MP0001963_abnormal_hearing_physiology	0.76000540
91	MP0001502_abnormal_circadian_rhythm	0.73598921
92	MP0000566_synostosis	0.73403304
93	MP0001501_abnormal_sleep_pattern	0.73198293
94	MP0002909_abnormal_adrenal_gland	0.72675032
95	MP0001145_abnormal_male_reproductive	0.72534652
96	MP0004147_increased_porphyrin_level	0.71790442
97	MP0002160_abnormal_reproductive_system	0.70743712
98	MP0004145_abnormal_muscle_electrophysio	0.70183478
99	MP0005646_abnormal_pituitary_gland	0.68801962
100	MP0001764_abnormal_homeostasis	0.67575779

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	3.83359090
2	True hermaphroditism (HP:0010459)	3.78524726
3	Gait imbalance (HP:0002141)	3.66220764
4	Pancreatic fibrosis (HP:0100732)	3.65246218
5	Molar tooth sign on MRI (HP:0002419)	3.61127687
6	Abnormality of midbrain morphology (HP:0002418)	3.61127687
7	Congenital primary aphakia (HP:0007707)	3.50248165
8	Abnormality of the labia minora (HP:0012880)	3.41130911
9	Nephrogenic diabetes insipidus (HP:0009806)	3.34357702
10	Pancreatic cysts (HP:0001737)	3.24144798
11	Nephronophthisis (HP:0000090)	3.18541200
12	Retinal dysplasia (HP:0007973)	3.10404821
13	Polyphagia (HP:0002591)	3.03496203
14	Chronic hepatic failure (HP:0100626)	2.99576609
15	Genital tract atresia (HP:0001827)	2.83951871
16	Pendular nystagmus (HP:0012043)	2.75770073
17	Vaginal atresia (HP:0000148)	2.73750540
18	Hemiparesis (HP:0001269)	2.71933462
19	Focal motor seizures (HP:0011153)	2.67690079
20	Optic nerve hypoplasia (HP:0000609)	2.65901645
21	Broad foot (HP:0001769)	2.55902214
22	Septo-optic dysplasia (HP:0100842)	2.55831480
23	Hyperglycinemia (HP:0002154)	2.54069201
24	Lissencephaly (HP:0001339)	2.52975648
25	Poor coordination (HP:0002370)	2.45174254
26	Abnormality of the renal medulla (HP:0100957)	2.44876104
27	Postaxial foot polydactyly (HP:0001830)	2.40249080
28	Specific learning disability (HP:0001328)	2.40041548
29	Colon cancer (HP:0003003)	2.39459513
30	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.37224724
31	Abolished electroretinogram (ERG) (HP:0000550)	2.36431790
32	Cortical dysplasia (HP:0002539)	2.32616494
33	Short tibia (HP:0005736)	2.31798925
34	Type II lissencephaly (HP:0007260)	2.31712802
35	Aplasia/Hypoplasia of the lens (HP:0008063)	2.30818660
36	Focal seizures (HP:0007359)	2.30248123
37	Agitation (HP:0000713)	2.29313751
38	Optic nerve coloboma (HP:0000588)	2.29149207
39	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.28525237
40	Postaxial hand polydactyly (HP:0001162)	2.27486730
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.25705857
42	Occipital encephalocele (HP:0002085)	2.23935544
43	Atonic seizures (HP:0010819)	2.21693246
44	Sclerocornea (HP:0000647)	2.20592705
45	Oligodactyly (hands) (HP:0001180)	2.20061024
46	Hyperventilation (HP:0002883)	2.19704476
47	Abnormal biliary tract physiology (HP:0012439)	2.18277292
48	Bile duct proliferation (HP:0001408)	2.18277292
49	Intestinal atresia (HP:0011100)	2.17889219
50	Cystic liver disease (HP:0006706)	2.15143651
51	Narrow forehead (HP:0000341)	2.13733785
52	Methylmalonic acidemia (HP:0002912)	2.12820198
53	Anencephaly (HP:0002323)	2.12193295
54	Preaxial hand polydactyly (HP:0001177)	2.08432719
55	Abnormality of glycine metabolism (HP:0010895)	2.07313091
56	Abnormality of serine family amino acid metabolism (HP:0010894)	2.07313091
57	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.07312115
58	Hypoplasia of the fovea (HP:0007750)	2.07312115
59	Hip dysplasia (HP:0001385)	2.06252182
60	Limb dystonia (HP:0002451)	2.05700910
61	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.04182679
62	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.04182679
63	Pachygyria (HP:0001302)	2.03048826
64	Hyperglycinuria (HP:0003108)	2.02688009
65	Myokymia (HP:0002411)	2.02476615
66	Failure to thrive in infancy (HP:0001531)	2.02293872
67	Abnormal ciliary motility (HP:0012262)	1.98969795
68	Acute necrotizing encephalopathy (HP:0006965)	1.97377620
69	Median cleft lip (HP:0000161)	1.92793242
70	Oculomotor apraxia (HP:0000657)	1.91383531
71	Aganglionic megacolon (HP:0002251)	1.91060887
72	Drooling (HP:0002307)	1.90951979
73	Tubulointerstitial nephritis (HP:0001970)	1.90776102
74	Anophthalmia (HP:0000528)	1.90456238
75	Abnormality of the corticospinal tract (HP:0002492)	1.89409370
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.89219519
77	Abnormal mitochondria in muscle tissue (HP:0008316)	1.87758742
78	Congenital hepatic fibrosis (HP:0002612)	1.85574265
79	Acute encephalopathy (HP:0006846)	1.84017853
80	Gonadotropin excess (HP:0000837)	1.83422946
81	Growth hormone deficiency (HP:0000824)	1.82979518
82	Increased CSF lactate (HP:0002490)	1.82780724
83	Abnormality of the fovea (HP:0000493)	1.81487705
84	Abnormality of the lower motor neuron (HP:0002366)	1.80963146
85	Decreased testicular size (HP:0008734)	1.80951014
86	Spastic tetraplegia (HP:0002510)	1.78367768
87	Oligodactyly (HP:0012165)	1.77659183
88	Amyotrophic lateral sclerosis (HP:0007354)	1.77414527
89	Abnormal respiratory motile cilium physiology (HP:0012261)	1.76065819
90	Medulloblastoma (HP:0002885)	1.75673649
91	Dandy-Walker malformation (HP:0001305)	1.75357826
92	Congenital stationary night blindness (HP:0007642)	1.73632577
93	Male pseudohermaphroditism (HP:0000037)	1.73047348
94	Abnormal eating behavior (HP:0100738)	1.71426172
95	Multicystic kidney dysplasia (HP:0000003)	1.71330314
96	Short foot (HP:0001773)	1.70571204
97	Mitochondrial inheritance (HP:0001427)	1.69742052
98	Abnormal rod and cone electroretinograms (HP:0008323)	1.68620048
99	Micropenis (HP:0000054)	1.68547923
100	Cerebellar dysplasia (HP:0007033)	1.67829444

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	3.14856471
2	PINK1	2.97101924
3	MARK1	2.72238199
4	MAPK13	2.61669451
5	CASK	2.58674730
6	BCR	2.51938543
7	MAP3K4	2.49237604
8	NUAK1	2.45553058
9	WNK3	2.42343590
10	DYRK2	2.07318048
11	PAK3	2.04437268
12	MAP2K7	2.02902963
13	STK16	1.96331423
14	BCKDK	1.88032776
15	MAP4K2	1.83549072
16	FRK	1.81900723
17	NTRK3	1.77851372
18	PLK2	1.72086470
19	EPHA3	1.71894875
20	BMPR1B	1.66013888
21	CDK19	1.64268899
22	CSNK1G3	1.64121120
23	NTRK2	1.60259041
24	CSNK1G2	1.60070984
25	ZAK	1.57366440
26	EPHA4	1.55126794
27	ADRBK2	1.54833077
28	CSNK1G1	1.48247541
29	MKNK1	1.41251286
30	PNCK	1.37408418
31	CSNK1A1L	1.33700571
32	MKNK2	1.33639427
33	SRPK1	1.30124347
34	ERBB3	1.27919169
35	WNK4	1.22118294
36	GRK1	1.16883723
37	DYRK3	1.12360165
38	PRKCG	1.12021723
39	TNIK	1.09490400
40	ERBB4	1.08011348
41	VRK2	0.93450733
42	EIF2AK3	0.93091681
43	PKN1	0.92761336
44	PTK2B	0.91520065
45	NEK1	0.90387792
46	PRKCE	0.89399311
47	STK39	0.88842028
48	PAK6	0.88488344
49	STK38L	0.87556556
50	PLK3	0.86799691
51	LIMK1	0.85127780
52	UHMK1	0.81688155
53	WEE1	0.81461862
54	OXSR1	0.81030189
55	TTK	0.79914754
56	MINK1	0.79898368
57	INSRR	0.76785498
58	CDC7	0.73494523
59	VRK1	0.71255656
60	KSR1	0.68995086
61	PIK3CA	0.68177631
62	PDK2	0.66660432
63	RPS6KA4	0.65676114
64	PLK1	0.63459567
65	CAMK2A	0.62156509
66	TSSK6	0.61311706
67	DYRK1A	0.59988623
68	EPHB2	0.58274654
69	MAP2K4	0.57168851
70	RPS6KA5	0.56244333
71	CDK5	0.55776553
72	CDK3	0.55127056
73	BUB1	0.52132650
74	BRSK2	0.51980819
75	SIK3	0.51437230
76	MAPKAPK5	0.51379991
77	CAMKK2	0.49657532
78	MAPK15	0.47221101
79	LATS1	0.45975916
80	TIE1	0.45946965
81	ATR	0.44526865
82	RAF1	0.44215295
83	BRAF	0.44122244
84	CDK14	0.44086339
85	PBK	0.43865556
86	TGFBR1	0.43735759
87	SGK494	0.43053916
88	SGK223	0.43053916
89	CDK18	0.41559219
90	PRKACA	0.40055008
91	FLT3	0.38157434
92	BRSK1	0.37377263
93	CSNK1A1	0.35839378
94	PLK4	0.35567205
95	CDK11A	0.35372819
96	ERBB2	0.35293367
97	CDK15	0.35170672
98	DYRK1B	0.34551037
99	PRKACB	0.34438772
100	PHKG2	0.33908284

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.18282167
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.93910572
3	Steroid biosynthesis_Homo sapiens_hsa00100	2.67365450
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.46838133
5	Protein export_Homo sapiens_hsa03060	2.38467176
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32666585
7	Phototransduction_Homo sapiens_hsa04744	2.26435703
8	Nicotine addiction_Homo sapiens_hsa05033	2.25433274
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.22635035
10	Butanoate metabolism_Homo sapiens_hsa00650	2.19553206
11	Parkinsons disease_Homo sapiens_hsa05012	2.01698603
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.85769097
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.84767125
14	Fatty acid elongation_Homo sapiens_hsa00062	1.84637880
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.82678326
16	Propanoate metabolism_Homo sapiens_hsa00640	1.79831375
17	Basal transcription factors_Homo sapiens_hsa03022	1.75846276
18	RNA degradation_Homo sapiens_hsa03018	1.66718999
19	Huntingtons disease_Homo sapiens_hsa05016	1.58344566
20	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.51770504
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.48349429
22	RNA polymerase_Homo sapiens_hsa03020	1.48134610
23	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.47819775
24	Collecting duct acid secretion_Homo sapiens_hsa04966	1.46319193
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.39054244
26	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.37755454
27	Homologous recombination_Homo sapiens_hsa03440	1.31515015
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.28664818
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.26199558
30	GABAergic synapse_Homo sapiens_hsa04727	1.23470083
31	Peroxisome_Homo sapiens_hsa04146	1.23469854
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.21611234
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.21162779
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.20308007
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.19803878
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.19059685
37	Linoleic acid metabolism_Homo sapiens_hsa00591	1.17177292
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.10569493
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.08417390
40	Base excision repair_Homo sapiens_hsa03410	1.08107903
41	Alzheimers disease_Homo sapiens_hsa05010	1.05736934
42	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.03147641
43	Mismatch repair_Homo sapiens_hsa03430	1.01507985
44	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.01346784
45	Olfactory transduction_Homo sapiens_hsa04740	1.00984337
46	Regulation of autophagy_Homo sapiens_hsa04140	1.00545020
47	Basal cell carcinoma_Homo sapiens_hsa05217	0.99618877
48	Taste transduction_Homo sapiens_hsa04742	0.99247022
49	Fatty acid metabolism_Homo sapiens_hsa01212	0.99087121
50	Morphine addiction_Homo sapiens_hsa05032	0.97338313
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.97080869
52	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.93003723
53	Nucleotide excision repair_Homo sapiens_hsa03420	0.89383791
54	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.89129439
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.87988114
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.86257835
57	Cocaine addiction_Homo sapiens_hsa05030	0.85979865
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.85855573
59	Oocyte meiosis_Homo sapiens_hsa04114	0.85351347
60	Axon guidance_Homo sapiens_hsa04360	0.84889354
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.84715437
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.84605734
63	Insulin secretion_Homo sapiens_hsa04911	0.80862900
64	Circadian entrainment_Homo sapiens_hsa04713	0.80600818
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79508241
66	RNA transport_Homo sapiens_hsa03013	0.72409894
67	Metabolic pathways_Homo sapiens_hsa01100	0.70990657
68	Folate biosynthesis_Homo sapiens_hsa00790	0.68442629
69	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.67303967
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66147727
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.63402310
72	Amphetamine addiction_Homo sapiens_hsa05031	0.61346639
73	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.60312386
74	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.60233214
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59868250
76	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.58607363
77	Serotonergic synapse_Homo sapiens_hsa04726	0.55306093
78	Caffeine metabolism_Homo sapiens_hsa00232	0.54646360
79	Proteasome_Homo sapiens_hsa03050	0.53563477
80	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.51030591
81	Purine metabolism_Homo sapiens_hsa00230	0.50076596
82	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49599506
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.49046926
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.48389619
85	Retinol metabolism_Homo sapiens_hsa00830	0.48013606
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.47723586
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46092117
88	Pyrimidine metabolism_Homo sapiens_hsa00240	0.45240710
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.42997851
90	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.42414989
91	Carbon metabolism_Homo sapiens_hsa01200	0.42313838
92	Long-term depression_Homo sapiens_hsa04730	0.41225955
93	Fatty acid degradation_Homo sapiens_hsa00071	0.41213456
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39952955
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39945486
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39830807
97	mRNA surveillance pathway_Homo sapiens_hsa03015	0.37339943
98	Chemical carcinogenesis_Homo sapiens_hsa05204	0.35769232
99	Glutathione metabolism_Homo sapiens_hsa00480	0.35666067
100	Circadian rhythm_Homo sapiens_hsa04710	0.35503147

ZNF177

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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