ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.81919737
2	piRNA metabolic process (GO:0034587)	4.70518487
3	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.35622598
4	respiratory chain complex IV assembly (GO:0008535)	4.06317822
5	response to pheromone (GO:0019236)	4.04919349
6	neutrophil activation involved in immune response (GO:0002283)	3.64787397
7	regulation of B cell receptor signaling pathway (GO:0050855)	3.63423879
8	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.50780560
9	interferon-gamma secretion (GO:0072643)	3.50195833
10	cytochrome complex assembly (GO:0017004)	3.43223749
11	proteasome assembly (GO:0043248)	3.33881662
12	DNA methylation involved in gamete generation (GO:0043046)	3.30102467
13	single strand break repair (GO:0000012)	3.22277152
14	leukotriene biosynthetic process (GO:0019370)	3.18476644
15	DNA double-strand break processing (GO:0000729)	3.13782454
16	DNA demethylation (GO:0080111)	3.11134318
17	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.07533955
18	protein-cofactor linkage (GO:0018065)	2.99554318
19	rRNA modification (GO:0000154)	2.98547620
20	RNA destabilization (GO:0050779)	2.96977790
21	maturation of 5.8S rRNA (GO:0000460)	2.92513814
22	rRNA methylation (GO:0031167)	2.91303629
23	protein K6-linked ubiquitination (GO:0085020)	2.89742821
24	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.88363300
25	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.88363300
26	isotype switching (GO:0045190)	2.88363300
27	S-adenosylmethionine metabolic process (GO:0046500)	2.85844450
28	regulation of meiosis I (GO:0060631)	2.82964385
29	activated T cell proliferation (GO:0050798)	2.81249762
30	cytidine metabolic process (GO:0046087)	2.80573260
31	cytidine catabolic process (GO:0006216)	2.80573260
32	cytidine deamination (GO:0009972)	2.80573260
33	protein neddylation (GO:0045116)	2.74076979
34	positive regulation of granulocyte differentiation (GO:0030854)	2.74049597
35	protein deneddylation (GO:0000338)	2.72884835
36	cellular response to interleukin-15 (GO:0071350)	2.70819320
37	mannosylation (GO:0097502)	2.70510938
38	positive regulation of gamma-delta T cell activation (GO:0046645)	2.69056915
39	male meiosis I (GO:0007141)	2.67431855
40	positive regulation of histone H3-K4 methylation (GO:0051571)	2.67430143
41	organelle membrane fusion (GO:0090174)	2.66549929
42	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.66145087
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.66145087
44	autophagic vacuole fusion (GO:0000046)	2.64385382
45	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.61785280
46	synapsis (GO:0007129)	2.60694949
47	neutrophil activation (GO:0042119)	2.57961509
48	DNA dealkylation (GO:0035510)	2.57175101
49	cullin deneddylation (GO:0010388)	2.56201624
50	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.54399327
51	adaptation of signaling pathway (GO:0023058)	2.53454075
52	leukocyte degranulation (GO:0043299)	2.52742189
53	water-soluble vitamin biosynthetic process (GO:0042364)	2.52196735
54	termination of RNA polymerase III transcription (GO:0006386)	2.51035840
55	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.51035840
56	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.50963654
57	methionine biosynthetic process (GO:0009086)	2.50404925
58	positive regulation of B cell differentiation (GO:0045579)	2.47705029
59	interferon-gamma production (GO:0032609)	2.46638093
60	ribosome assembly (GO:0042255)	2.45954150
61	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.45175517
62	phosphatidylethanolamine metabolic process (GO:0046337)	2.44440022
63	positive regulation of defense response to virus by host (GO:0002230)	2.44175071
64	methionine metabolic process (GO:0006555)	2.43482086
65	pseudouridine synthesis (GO:0001522)	2.43362929
66	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.43095141
67	positive regulation of interleukin-17 production (GO:0032740)	2.42011740
68	negative regulation of telomere maintenance (GO:0032205)	2.41727545
69	male meiosis (GO:0007140)	2.41607434
70	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.41043507
71	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.40182550
72	regulation of interleukin-1 beta secretion (GO:0050706)	2.39434687
73	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.38529893
74	regulation of interferon-beta biosynthetic process (GO:0045357)	2.37645134
75	regulation of B cell differentiation (GO:0045577)	2.35039102
76	protein complex biogenesis (GO:0070271)	2.34621814
77	lymphoid progenitor cell differentiation (GO:0002320)	2.34551264
78	nucleotide transmembrane transport (GO:1901679)	2.34507927
79	defense response to protozoan (GO:0042832)	2.34129643
80	histone mRNA catabolic process (GO:0071044)	2.33853379
81	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.33570398
82	protein K11-linked deubiquitination (GO:0035871)	2.28990372
83	response to interleukin-15 (GO:0070672)	2.28558007
84	positive regulation of interleukin-1 secretion (GO:0050716)	2.26253217
85	regulation of alpha-beta T cell proliferation (GO:0046640)	2.25525064
86	glutathione biosynthetic process (GO:0006750)	2.25054920
87	transcription from mitochondrial promoter (GO:0006390)	2.24564916
88	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.24543962
89	negative regulation of cell killing (GO:0031342)	2.24543962
90	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.24341452
91	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.24341452
92	NADH dehydrogenase complex assembly (GO:0010257)	2.24341452
93	regulation of B cell apoptotic process (GO:0002902)	2.24008933
94	gene silencing by RNA (GO:0031047)	2.23642390
95	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.23561382
96	transcription from RNA polymerase III promoter (GO:0006383)	2.23346638
97	mitochondrial RNA metabolic process (GO:0000959)	2.23259735
98	mast cell activation involved in immune response (GO:0002279)	2.23124363
99	mast cell degranulation (GO:0043303)	2.23124363
100	response to protozoan (GO:0001562)	2.22633417

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.63295846
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.47520498
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.32184061
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.04970801
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.95803400
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.94825892
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.72864942
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.56035539
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.51630755
10	VDR_22108803_ChIP-Seq_LS180_Human	2.50690763
11	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.45447741
12	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.36259200
13	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.30666336
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18298735
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.15684988
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.13048793
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.12262189
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.07463677
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.01253983
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00225707
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.90516613
22	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.90480731
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.87060150
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.75948799
25	GATA1_22025678_ChIP-Seq_K562_Human	1.75526657
26	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.74669641
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73502594
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71842905
29	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.70935130
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.67386997
31	MYB_26560356_Chip-Seq_TH2_Human	1.65754835
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.63946001
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.58914829
34	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.54002702
35	SPI1_23547873_ChIP-Seq_NB4_Human	1.50596199
36	GATA3_26560356_Chip-Seq_TH2_Human	1.49428931
37	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46496965
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.44968463
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44438121
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.43055088
41	EWS_26573619_Chip-Seq_HEK293_Human	1.40045180
42	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.39567922
43	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.39282266
44	ER_23166858_ChIP-Seq_MCF-7_Human	1.38155068
45	GATA3_27048872_Chip-Seq_THYMUS_Human	1.36271882
46	FUS_26573619_Chip-Seq_HEK293_Human	1.36004642
47	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.30572328
48	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.30085932
49	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.27773793
50	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.25708819
51	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23177675
52	P300_19829295_ChIP-Seq_ESCs_Human	1.22347434
53	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.21716161
54	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.21126454
55	GBX2_23144817_ChIP-Seq_PC3_Human	1.20101602
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.20087498
57	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.18018644
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.17666277
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17666277
60	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.16641375
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.15036730
62	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.12804540
63	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.12242343
64	* GABP_19822575_ChIP-Seq_HepG2_Human	1.11396529
65	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.11357227
66	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.11135663
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11008934
68	GATA3_26560356_Chip-Seq_TH1_Human	1.10697687
69	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.10571035
70	NCOR_22424771_ChIP-Seq_293T_Human	1.09845407
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08583271
72	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.08559936
73	RUNX_20019798_ChIP-Seq_JUKART_Human	1.08364281
74	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.08205600
75	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.08185227
76	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.07723572
77	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.07551857
78	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.03877044
79	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03531434
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03531434
81	IRF1_19129219_ChIP-ChIP_H3396_Human	1.01867793
82	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.00388349
83	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.00388349
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99996625
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99927485
86	BCAT_22108803_ChIP-Seq_LS180_Human	0.99795204
87	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.99751768
88	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98486605
89	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98071229
90	MYB_26560356_Chip-Seq_TH1_Human	0.96583594
91	AR_20517297_ChIP-Seq_VCAP_Human	0.96335876
92	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93651273
93	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93579831
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93290899
95	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92935469
96	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.92892796
97	TAF15_26573619_Chip-Seq_HEK293_Human	0.91809872
98	* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90684849
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90251392
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89453382

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.57832472
2	MP0003646_muscle_fatigue	2.97284520
3	MP0008995_early_reproductive_senescence	2.86385112
4	MP0001835_abnormal_antigen_presentation	2.77816273
5	MP0002102_abnormal_ear_morphology	2.66589330
6	MP0005671_abnormal_response_to	2.54459626
7	MP0005075_abnormal_melanosome_morpholog	2.50796362
8	MP0000372_irregular_coat_pigmentation	2.38584706
9	MP0008877_abnormal_DNA_methylation	2.31946036
10	MP0003786_premature_aging	2.28732952
11	MP0003724_increased_susceptibility_to	2.25719615
12	MP0008058_abnormal_DNA_repair	2.23487189
13	MP0000685_abnormal_immune_system	2.19261154
14	MP0009785_altered_susceptibility_to	2.15931597
15	MP0001800_abnormal_humoral_immune	2.05388188
16	MP0001873_stomach_inflammation	1.94912985
17	MP0003763_abnormal_thymus_physiology	1.77956355
18	MP0002148_abnormal_hypersensitivity_rea	1.76101806
19	MP0003011_delayed_dark_adaptation	1.73946972
20	MP0002876_abnormal_thyroid_physiology	1.73013740
21	MP0002396_abnormal_hematopoietic_system	1.72203612
22	MP0002837_dystrophic_cardiac_calcinosis	1.71555549
23	MP0002723_abnormal_immune_serum	1.70239793
24	MP0005000_abnormal_immune_tolerance	1.65514396
25	MP0004147_increased_porphyrin_level	1.64733232
26	MP0005645_abnormal_hypothalamus_physiol	1.64593880
27	MP0005387_immune_system_phenotype	1.64474812
28	MP0001790_abnormal_immune_system	1.64474812
29	MP0000465_gastrointestinal_hemorrhage	1.60236299
30	MP0002420_abnormal_adaptive_immunity	1.58233150
31	MP0002254_reproductive_system_inflammat	1.58125836
32	MP0002452_abnormal_antigen_presenting	1.58039818
33	MP0001819_abnormal_immune_cell	1.56870493
34	MP0000689_abnormal_spleen_morphology	1.56278874
35	MP0005084_abnormal_gallbladder_morpholo	1.53988781
36	MP0005310_abnormal_salivary_gland	1.47554001
37	MP0002163_abnormal_gland_morphology	1.46835271
38	MP0002138_abnormal_hepatobiliary_system	1.45511169
39	MP0010094_abnormal_chromosome_stability	1.43652831
40	MP0002419_abnormal_innate_immunity	1.43530568
41	MP0003436_decreased_susceptibility_to	1.42539973
42	MP0001986_abnormal_taste_sensitivity	1.42302252
43	MP0002398_abnormal_bone_marrow	1.41350537
44	MP0003718_maternal_effect	1.38804586
45	MP0005025_abnormal_response_to	1.37753915
46	MP0004381_abnormal_hair_follicle	1.33862195
47	MP0002277_abnormal_respiratory_mucosa	1.31961600
48	MP0002405_respiratory_system_inflammati	1.30953447
49	MP0006292_abnormal_olfactory_placode	1.30635874
50	MP0000015_abnormal_ear_pigmentation	1.30135210
51	MP0000716_abnormal_immune_system	1.23503464
52	MP0008789_abnormal_olfactory_epithelium	1.21707523
53	MP0002722_abnormal_immune_system	1.21098022
54	MP0004142_abnormal_muscle_tone	1.21015913
55	MP0000703_abnormal_thymus_morphology	1.18141274
56	MP0001764_abnormal_homeostasis	1.15393451
57	MP0005389_reproductive_system_phenotype	1.13232289
58	MP0001919_abnormal_reproductive_system	1.12815445
59	MP0008875_abnormal_xenobiotic_pharmacok	1.08195508
60	MP0003252_abnormal_bile_duct	1.05713002
61	MP0005551_abnormal_eye_electrophysiolog	1.05404566
62	MP0005646_abnormal_pituitary_gland	1.04080919
63	MP0001929_abnormal_gametogenesis	1.03381378
64	MP0006036_abnormal_mitochondrial_physio	1.02753669
65	MP0000427_abnormal_hair_cycle	0.99202050
66	MP0002429_abnormal_blood_cell	0.98584193
67	MP0003656_abnormal_erythrocyte_physiolo	0.97939492
68	MP0009333_abnormal_splenocyte_physiolog	0.96709426
69	MP0001845_abnormal_inflammatory_respons	0.96373021
70	MP0002095_abnormal_skin_pigmentation	0.94638988
71	MP0005410_abnormal_fertilization	0.94375559
72	MP0005379_endocrine/exocrine_gland_phen	0.94332955
73	MP0006035_abnormal_mitochondrial_morpho	0.94214797
74	MP0002928_abnormal_bile_duct	0.93650175
75	MP0000569_abnormal_digit_pigmentation	0.91675107
76	MP0005499_abnormal_olfactory_system	0.90716346
77	MP0005394_taste/olfaction_phenotype	0.90716346
78	MP0005395_other_phenotype	0.89271065
79	MP0002653_abnormal_ependyma_morphology	0.88863468
80	MP0002160_abnormal_reproductive_system	0.85939649
81	MP0003567_abnormal_fetal_cardiomyocyte	0.85881000
82	MP0002210_abnormal_sex_determination	0.84406486
83	MP0003806_abnormal_nucleotide_metabolis	0.84142969
84	MP0008469_abnormal_protein_level	0.82680014
85	MP0003303_peritoneal_inflammation	0.82621550
86	MP0008872_abnormal_physiological_respon	0.81567685
87	MP0005464_abnormal_platelet_physiology	0.79775596
88	MP0010155_abnormal_intestine_physiology	0.78989204
89	MP0000653_abnormal_sex_gland	0.78246068
90	MP0003186_abnormal_redox_activity	0.77814149
91	MP0001501_abnormal_sleep_pattern	0.77029456
92	MP0010307_abnormal_tumor_latency	0.76918358
93	MP0005365_abnormal_bile_salt	0.76700233
94	MP0005174_abnormal_tail_pigmentation	0.76132102
95	MP0009764_decreased_sensitivity_to	0.75435614
96	MP0005253_abnormal_eye_physiology	0.74995080
97	MP0001145_abnormal_male_reproductive	0.74388152
98	MP0002166_altered_tumor_susceptibility	0.73285664
99	MP0001119_abnormal_female_reproductive	0.72763469
100	MP0003787_abnormal_imprinting	0.72385752

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	4.20135670
2	Abnormal rod and cone electroretinograms (HP:0008323)	3.10278994
3	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.95143801
4	Lipid accumulation in hepatocytes (HP:0006561)	2.94988762
5	Pancreatic cysts (HP:0001737)	2.86316299
6	Increased hepatocellular lipid droplets (HP:0006565)	2.78435376
7	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.77167975
8	Optic neuritis (HP:0100653)	2.68744269
9	Retrobulbar optic neuritis (HP:0100654)	2.68744269
10	Severe combined immunodeficiency (HP:0004430)	2.67902174
11	Panhypogammaglobulinemia (HP:0003139)	2.61602830
12	Myositis (HP:0100614)	2.57660940
13	Elevated erythrocyte sedimentation rate (HP:0003565)	2.57210249
14	Chronic mucocutaneous candidiasis (HP:0002728)	2.51125241
15	Recurrent cutaneous fungal infections (HP:0011370)	2.51125241
16	Renal cortical cysts (HP:0000803)	2.44310326
17	Pancreatic fibrosis (HP:0100732)	2.44063655
18	Thyroiditis (HP:0100646)	2.41328865
19	Abolished electroretinogram (ERG) (HP:0000550)	2.39271515
20	Abnormality of macular pigmentation (HP:0008002)	2.37804363
21	Increased CSF lactate (HP:0002490)	2.36216743
22	Abnormality of homocysteine metabolism (HP:0010919)	2.36054667
23	Homocystinuria (HP:0002156)	2.36054667
24	IgG deficiency (HP:0004315)	2.35446568
25	Mitochondrial inheritance (HP:0001427)	2.35392966
26	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.35292347
27	Attenuation of retinal blood vessels (HP:0007843)	2.34551749
28	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.33322113
29	Orchitis (HP:0100796)	2.32076844
30	Abnormality of T cells (HP:0002843)	2.30747578
31	Abnormality of the renal cortex (HP:0011035)	2.29010877
32	Renal Fanconi syndrome (HP:0001994)	2.28653916
33	Bile duct proliferation (HP:0001408)	2.24240088
34	Abnormal biliary tract physiology (HP:0012439)	2.24240088
35	T lymphocytopenia (HP:0005403)	2.23720792
36	Decreased central vision (HP:0007663)	2.22882414
37	Abnormality of T cell physiology (HP:0011840)	2.20976775
38	Abnormality of chromosome stability (HP:0003220)	2.20973081
39	Recurrent fungal infections (HP:0002841)	2.19715213
40	Congenital stationary night blindness (HP:0007642)	2.19655969
41	Type II lissencephaly (HP:0007260)	2.19626334
42	Type 2 muscle fiber atrophy (HP:0003554)	2.19358238
43	Acute necrotizing encephalopathy (HP:0006965)	2.18933401
44	True hermaphroditism (HP:0010459)	2.18833994
45	Pulmonary infiltrates (HP:0002113)	2.17142932
46	Abnormality of T cell number (HP:0011839)	2.16322066
47	Medial flaring of the eyebrow (HP:0010747)	2.13933607
48	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.13408396
49	Abnormality of the prostate (HP:0008775)	2.12190045
50	Gonadotropin excess (HP:0000837)	2.11997128
51	Encephalitis (HP:0002383)	2.05971080
52	Abnormality of the preputium (HP:0100587)	2.05681034
53	Abnormality of eosinophils (HP:0001879)	2.03409538
54	Methylmalonic acidemia (HP:0002912)	2.02288258
55	Combined immunodeficiency (HP:0005387)	2.01660421
56	Abnormality of the fovea (HP:0000493)	1.95714418
57	Abnormality of vitamin B metabolism (HP:0004340)	1.95543736
58	Abnormality of midbrain morphology (HP:0002418)	1.95230552
59	Molar tooth sign on MRI (HP:0002419)	1.95230552
60	Abnormality of the ileum (HP:0001549)	1.93894611
61	Prostate neoplasm (HP:0100787)	1.93729301
62	Acute encephalopathy (HP:0006846)	1.93411057
63	3-Methylglutaconic aciduria (HP:0003535)	1.92886440
64	Increased serum lactate (HP:0002151)	1.92245806
65	Respiratory difficulties (HP:0002880)	1.92109784
66	Meckel diverticulum (HP:0002245)	1.91698264
67	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.90848658
68	Agammaglobulinemia (HP:0004432)	1.89694282
69	Progressive macrocephaly (HP:0004481)	1.88918675
70	Abnormality of urine glucose concentration (HP:0011016)	1.88313637
71	Glycosuria (HP:0003076)	1.88313637
72	Pendular nystagmus (HP:0012043)	1.87538100
73	Gonadal dysgenesis (HP:0000133)	1.87537134
74	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.86745380
75	Abnormal protein N-linked glycosylation (HP:0012347)	1.86745380
76	Abnormal protein glycosylation (HP:0012346)	1.86745380
77	Abnormal glycosylation (HP:0012345)	1.86745380
78	Leukocytosis (HP:0001974)	1.86225704
79	Pustule (HP:0200039)	1.86183226
80	Severe visual impairment (HP:0001141)	1.84616736
81	Clubbing of toes (HP:0100760)	1.84366462
82	Hypochromic microcytic anemia (HP:0004840)	1.83248383
83	Keratoconjunctivitis (HP:0001096)	1.79242133
84	Type I transferrin isoform profile (HP:0003642)	1.78929531
85	Nephronophthisis (HP:0000090)	1.78790272
86	Constricted visual fields (HP:0001133)	1.78491726
87	Exertional dyspnea (HP:0002875)	1.78414151
88	Nephrogenic diabetes insipidus (HP:0009806)	1.78370859
89	Hepatocellular necrosis (HP:0001404)	1.77920240
90	Progressive inability to walk (HP:0002505)	1.76613050
91	Hypoplasia of the thymus (HP:0000778)	1.76152423
92	Hyperglycinemia (HP:0002154)	1.76014878
93	Polydipsia (HP:0001959)	1.74814096
94	Abnormal drinking behavior (HP:0030082)	1.74814096
95	Recurrent bronchitis (HP:0002837)	1.74453476
96	Albinism (HP:0001022)	1.74446959
97	Meningitis (HP:0001287)	1.74116188
98	Abnormal mitochondria in muscle tissue (HP:0008316)	1.72099166
99	Increased IgM level (HP:0003496)	1.71306699
100	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.71062782

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.66590876
2	TXK	3.20128471
3	WNK3	2.74804479
4	EIF2AK3	2.69549636
5	MST4	2.65717057
6	PINK1	2.50298102
7	NUAK1	2.29743692
8	FRK	2.21852114
9	ZAK	2.13229739
10	OXSR1	1.89593567
11	BMPR1B	1.86866427
12	TEC	1.85064735
13	GRK1	1.82515641
14	TRIM28	1.77255691
15	CDK19	1.77216979
16	ADRBK2	1.70162807
17	NLK	1.65831796
18	BCKDK	1.65171761
19	TSSK6	1.62166285
20	MAP4K1	1.59019958
21	TAOK3	1.58305720
22	INSRR	1.48848738
23	STK39	1.46444791
24	FES	1.43325436
25	IKBKE	1.41734976
26	TNK2	1.38867954
27	KIT	1.36668546
28	RIPK4	1.30772325
29	IKBKB	1.30042376
30	MUSK	1.28659515
31	FLT3	1.23517833
32	IRAK4	1.20452318
33	SYK	1.15307152
34	BTK	1.14747832
35	ITK	1.14036645
36	TYK2	1.09027288
37	ACVR1B	1.06732854
38	MAPK13	0.97833707
39	VRK2	0.95517731
40	LYN	0.95326549
41	PIK3CG	0.92333370
42	CSNK1G1	0.87425213
43	MAP3K5	0.85596102
44	PRKCQ	0.83982716
45	BCR	0.82020028
46	LCK	0.81367087
47	GRK6	0.81219983
48	MAP3K4	0.78812635
49	TAF1	0.78732246
50	HCK	0.78401415
51	CSF1R	0.77253350
52	PAK3	0.76016223
53	CSK	0.73388014
54	MATK	0.71912759
55	IRAK1	0.69634886
56	VRK1	0.68593708
57	SGK2	0.68591379
58	MKNK2	0.66847869
59	SIK3	0.65516584
60	TLK1	0.65494097
61	MAP3K14	0.64912790
62	BMPR2	0.63423063
63	MAP2K6	0.63168325
64	PLK3	0.62992031
65	CCNB1	0.62838387
66	TBK1	0.59197853
67	MARK3	0.58771134
68	BLK	0.57946507
69	DYRK2	0.56067124
70	ABL1	0.54800046
71	CDK3	0.54662996
72	MAP2K3	0.54133455
73	PLK2	0.53713375
74	JAK3	0.52136667
75	PIM1	0.51628748
76	PLK4	0.51505576
77	EIF2AK2	0.50088316
78	ATR	0.48477154
79	MELK	0.47746072
80	RPS6KA4	0.47077345
81	CSNK1G3	0.46772742
82	DAPK1	0.44768923
83	CSNK1A1L	0.43329720
84	MAPKAPK5	0.42784077
85	IGF1R	0.42783067
86	STK16	0.42141233
87	PASK	0.41856181
88	ZAP70	0.41530515
89	CDK9	0.40562840
90	ADRBK1	0.40338280
91	EIF2AK1	0.40107913
92	MKNK1	0.39448551
93	CSNK1G2	0.37885936
94	NTRK3	0.34911951
95	AKT3	0.34801383
96	STK11	0.34058650
97	SRPK1	0.33039755
98	MAP3K3	0.31027657
99	CSNK2A2	0.30247626
100	MAPK7	0.29219844

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	3.11078524
2	Proteasome_Homo sapiens_hsa03050	2.83668873
3	Selenocompound metabolism_Homo sapiens_hsa00450	2.80410636
4	RNA polymerase_Homo sapiens_hsa03020	2.45281705
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.36595922
6	Homologous recombination_Homo sapiens_hsa03440	2.29262855
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.23665763
8	Protein export_Homo sapiens_hsa03060	2.22958105
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.22547441
10	Allograft rejection_Homo sapiens_hsa05330	2.18197533
11	One carbon pool by folate_Homo sapiens_hsa00670	2.15449915
12	Basal transcription factors_Homo sapiens_hsa03022	2.07323132
13	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.05847796
14	Type I diabetes mellitus_Homo sapiens_hsa04940	2.01692995
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.00377695
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.97880528
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.86499815
18	RNA degradation_Homo sapiens_hsa03018	1.79230668
19	Caffeine metabolism_Homo sapiens_hsa00232	1.78368535
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.74925812
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.67902800
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.66433654
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.62220572
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.60747499
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.59813257
26	Peroxisome_Homo sapiens_hsa04146	1.45954715
27	Asthma_Homo sapiens_hsa05310	1.44297306
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43694782
29	Regulation of autophagy_Homo sapiens_hsa04140	1.39376982
30	Phototransduction_Homo sapiens_hsa04744	1.32988118
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.31776906
32	Parkinsons disease_Homo sapiens_hsa05012	1.31272280
33	Antigen processing and presentation_Homo sapiens_hsa04612	1.27635585
34	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.26004671
35	Butanoate metabolism_Homo sapiens_hsa00650	1.25842288
36	Propanoate metabolism_Homo sapiens_hsa00640	1.18735002
37	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.11703542
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.11128680
39	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.10755341
40	Rheumatoid arthritis_Homo sapiens_hsa05323	1.08013135
41	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.07860812
42	RNA transport_Homo sapiens_hsa03013	1.07397858
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.06052161
44	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.03829929
45	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.02274377
46	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00115558
47	Base excision repair_Homo sapiens_hsa03410	0.98536539
48	Herpes simplex infection_Homo sapiens_hsa05168	0.97185206
49	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.96405761
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.96274916
51	Measles_Homo sapiens_hsa05162	0.94957271
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.93757857
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.91629713
54	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.90646724
55	Mismatch repair_Homo sapiens_hsa03430	0.87876407
56	Legionellosis_Homo sapiens_hsa05134	0.87034031
57	Purine metabolism_Homo sapiens_hsa00230	0.85474511
58	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.82129452
59	Huntingtons disease_Homo sapiens_hsa05016	0.78060325
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.77666643
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76481123
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75517021
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.74974570
64	Leishmaniasis_Homo sapiens_hsa05140	0.74960709
65	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.74834984
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.68969645
67	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.67685152
68	Osteoclast differentiation_Homo sapiens_hsa04380	0.66887694
69	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.63246849
70	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62797403
71	Tuberculosis_Homo sapiens_hsa05152	0.60614474
72	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.59644721
73	Retinol metabolism_Homo sapiens_hsa00830	0.59619424
74	p53 signaling pathway_Homo sapiens_hsa04115	0.58478138
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57197153
76	Nitrogen metabolism_Homo sapiens_hsa00910	0.57072376
77	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.55596552
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.55327906
79	Viral myocarditis_Homo sapiens_hsa05416	0.54904133
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.54609477
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54281350
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53983666
83	African trypanosomiasis_Homo sapiens_hsa05143	0.51425713
84	Olfactory transduction_Homo sapiens_hsa04740	0.50430627
85	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.49765838
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48806504
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.48074453
88	Fatty acid elongation_Homo sapiens_hsa00062	0.46922880
89	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.46433531
90	Metabolic pathways_Homo sapiens_hsa01100	0.44911997
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42655389
92	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.37931602
93	Spliceosome_Homo sapiens_hsa03040	0.36838920
94	Alzheimers disease_Homo sapiens_hsa05010	0.35763434
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.33752613
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.32978354
97	Fatty acid degradation_Homo sapiens_hsa00071	0.32948573
98	ABC transporters_Homo sapiens_hsa02010	0.31793509
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.29795817
100	Folate biosynthesis_Homo sapiens_hsa00790	0.28842082

ZNF18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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