ZNF180

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of helicase activity (GO:0051095)4.32163464
2pyrimidine nucleobase catabolic process (GO:0006208)4.25480764
3mitotic sister chromatid cohesion (GO:0007064)4.20540468
4rRNA catabolic process (GO:0016075)4.16057378
5response to pheromone (GO:0019236)3.97609610
6kinetochore assembly (GO:0051382)3.97203204
7behavioral response to nicotine (GO:0035095)3.95120913
8kinetochore organization (GO:0051383)3.93421591
9negative regulation of DNA-dependent DNA replication (GO:2000104)3.72259454
10replication fork processing (GO:0031297)3.72008690
11resolution of meiotic recombination intermediates (GO:0000712)3.69609755
12DNA damage response, detection of DNA damage (GO:0042769)3.58949483
13chromatin remodeling at centromere (GO:0031055)3.56228661
14CENP-A containing nucleosome assembly (GO:0034080)3.50993498
15single strand break repair (GO:0000012)3.49148585
16water-soluble vitamin biosynthetic process (GO:0042364)3.47873440
17ncRNA catabolic process (GO:0034661)3.46393452
18metaphase plate congression (GO:0051310)3.46003231
19negative regulation of DNA recombination (GO:0045910)3.35387943
20regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.35377337
21regulation of mitotic spindle checkpoint (GO:1903504)3.35377337
22protein K11-linked deubiquitination (GO:0035871)3.35240029
23nucleobase catabolic process (GO:0046113)3.33510297
24meiotic chromosome segregation (GO:0045132)3.31339033
25recombinational repair (GO:0000725)3.26301051
26telomere maintenance via telomerase (GO:0007004)3.24161477
27double-strand break repair via homologous recombination (GO:0000724)3.22141500
28pseudouridine synthesis (GO:0001522)3.20239618
29phosphorylated carbohydrate dephosphorylation (GO:0046838)3.17778586
30inositol phosphate dephosphorylation (GO:0046855)3.17778586
31negative regulation of telomere maintenance (GO:0032205)3.16268280
32inositol phosphate catabolic process (GO:0071545)3.15138325
33negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.12413813
34RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11559261
35regulation of DNA endoreduplication (GO:0032875)3.10903209
36spermatid nucleus differentiation (GO:0007289)3.10240186
37polyol catabolic process (GO:0046174)3.09161819
38microtubule anchoring (GO:0034453)3.08961968
39acrosome assembly (GO:0001675)3.08183267
40microtubule depolymerization (GO:0007019)3.05786138
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00573465
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00352701
43somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96167787
44somatic hypermutation of immunoglobulin genes (GO:0016446)2.96167787
45regulation of telomere maintenance (GO:0032204)2.96020932
46maturation of 5.8S rRNA (GO:0000460)2.94320518
47maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.94182618
48reciprocal DNA recombination (GO:0035825)2.92311945
49reciprocal meiotic recombination (GO:0007131)2.92311945
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91468080
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91468080
52regulation of telomere maintenance via telomerase (GO:0032210)2.90510652
53piRNA metabolic process (GO:0034587)2.90184998
54ubiquinone biosynthetic process (GO:0006744)2.89836337
55histone mRNA metabolic process (GO:0008334)2.89622374
56regulation of centriole replication (GO:0046599)2.86819393
57histone exchange (GO:0043486)2.86723051
58DNA ligation (GO:0006266)2.84508810
59mitochondrial RNA metabolic process (GO:0000959)2.84305869
60histone H2A acetylation (GO:0043968)2.84061252
61ubiquinone metabolic process (GO:0006743)2.83393562
62base-excision repair, AP site formation (GO:0006285)2.80340131
63attachment of spindle microtubules to kinetochore (GO:0008608)2.78019889
64sister chromatid cohesion (GO:0007062)2.77429898
65regulation of nuclear cell cycle DNA replication (GO:0033262)2.77118317
66histone-serine phosphorylation (GO:0035404)2.76343264
67RNA-dependent DNA replication (GO:0006278)2.76228045
68regulation of meiosis I (GO:0060631)2.72945154
69protein localization to kinetochore (GO:0034501)2.71749832
70protein neddylation (GO:0045116)2.67013770
71nucleotide-excision repair, DNA gap filling (GO:0006297)2.65199834
72mitochondrial respiratory chain complex I assembly (GO:0032981)2.64711383
73NADH dehydrogenase complex assembly (GO:0010257)2.64711383
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64711383
75synapsis (GO:0007129)2.62715357
76DNA strand renaturation (GO:0000733)2.60886984
77postreplication repair (GO:0006301)2.60432219
78magnesium ion transport (GO:0015693)2.60278453
79positive regulation of mitotic sister chromatid separation (GO:1901970)2.59915921
80positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.59915921
81positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.59915921
82male meiosis I (GO:0007141)2.59150527
83establishment of chromosome localization (GO:0051303)2.58859960
84response to X-ray (GO:0010165)2.58854845
85double-strand break repair (GO:0006302)2.58121552
86mitotic metaphase plate congression (GO:0007080)2.57028582
87epithelial cilium movement (GO:0003351)2.56180112
88intraciliary transport (GO:0042073)2.56028991
89histone mRNA catabolic process (GO:0071044)2.55399153
90regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.53975339
91centriole replication (GO:0007099)2.53715093
92spindle checkpoint (GO:0031577)2.52456880
93regulation of posttranscriptional gene silencing (GO:0060147)2.52266310
94regulation of gene silencing by miRNA (GO:0060964)2.52266310
95regulation of gene silencing by RNA (GO:0060966)2.52266310
96DNA replication checkpoint (GO:0000076)2.50529040
97olfactory bulb development (GO:0021772)2.49677447
98DNA double-strand break processing (GO:0000729)2.49359149
99neural tube formation (GO:0001841)2.49217904
100negative regulation of chromosome segregation (GO:0051985)2.49084565

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.55725044
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31320840
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.23812348
4E2F7_22180533_ChIP-Seq_HELA_Human3.05983674
5FUS_26573619_Chip-Seq_HEK293_Human2.87862562
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85706491
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.71751232
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65519376
9* EST1_17652178_ChIP-ChIP_JURKAT_Human2.62362436
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56680831
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55681833
12ELK1_19687146_ChIP-ChIP_HELA_Human2.52951434
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50696892
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.44449399
15EWS_26573619_Chip-Seq_HEK293_Human2.42666445
16IGF1R_20145208_ChIP-Seq_DFB_Human2.13040554
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12384897
18VDR_22108803_ChIP-Seq_LS180_Human2.11160213
19VDR_23849224_ChIP-Seq_CD4+_Human2.10457129
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10251304
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.07733772
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06493233
23GBX2_23144817_ChIP-Seq_PC3_Human2.03387135
24TAF15_26573619_Chip-Seq_HEK293_Human1.94307998
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92956059
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.89450695
27* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85740950
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85319818
29FOXP3_21729870_ChIP-Seq_TREG_Human1.81027708
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79268090
31MYC_18940864_ChIP-ChIP_HL60_Human1.73552914
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71348301
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70179165
34* ETS1_20019798_ChIP-Seq_JURKAT_Human1.65475706
35P300_19829295_ChIP-Seq_ESCs_Human1.61931067
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59424380
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58721971
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55966829
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52431479
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.51970574
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50335783
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48920083
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45386520
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44942169
45ER_23166858_ChIP-Seq_MCF-7_Human1.42325908
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41666930
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40914164
48CBP_20019798_ChIP-Seq_JUKART_Human1.40914164
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39185075
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.37094200
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35726505
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.34818234
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31898831
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29825145
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29614764
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29599691
57TP53_22573176_ChIP-Seq_HFKS_Human1.28470230
58* STAT3_23295773_ChIP-Seq_U87_Human1.22947591
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22393131
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20550426
61IRF1_19129219_ChIP-ChIP_H3396_Human1.19448320
62SMAD4_21799915_ChIP-Seq_A2780_Human1.17863432
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14640133
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14629358
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13556207
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12375871
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.11062886
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10640229
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07193715
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07174781
71TTF2_22483619_ChIP-Seq_HELA_Human1.06663210
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06133412
73RNF2_27304074_Chip-Seq_NSC_Mouse1.05962017
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05819634
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.05154022
76GABP_19822575_ChIP-Seq_HepG2_Human1.03917236
77RUNX2_22187159_ChIP-Seq_PCA_Human1.02778025
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.02015620
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00729530
80NANOG_19829295_ChIP-Seq_ESCs_Human1.00658180
81SOX2_19829295_ChIP-Seq_ESCs_Human1.00658180
82KDM5A_27292631_Chip-Seq_BREAST_Human0.99019851
83NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98025697
84* TCF4_23295773_ChIP-Seq_U87_Human0.98012975
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97182082
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97182082
87* SOX2_16153702_ChIP-ChIP_HESCs_Human0.97176768
88DCP1A_22483619_ChIP-Seq_HELA_Human0.95876148
89* NCOR_22424771_ChIP-Seq_293T_Human0.94718866
90SRF_21415370_ChIP-Seq_HL-1_Mouse0.93071870
91FLI1_21867929_ChIP-Seq_TH2_Mouse0.92902706
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.92185614
93TCF4_22108803_ChIP-Seq_LS180_Human0.91946105
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.91768717
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91765994
96PIAS1_25552417_ChIP-Seq_VCAP_Human0.91632332
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91377370
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90733708
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89777327
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89761577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.65757700
2MP0008877_abnormal_DNA_methylation3.65752400
3MP0008058_abnormal_DNA_repair3.18819731
4MP0010094_abnormal_chromosome_stability2.87590389
5MP0006292_abnormal_olfactory_placode2.78729895
6MP0003787_abnormal_imprinting2.60466718
7MP0002163_abnormal_gland_morphology2.31540199
8MP0003890_abnormal_embryonic-extraembry2.31398982
9MP0001293_anophthalmia2.30649589
10MP0001919_abnormal_reproductive_system2.30314224
11MP0006072_abnormal_retinal_apoptosis2.25942710
12MP0000372_irregular_coat_pigmentation2.23519071
13MP0002160_abnormal_reproductive_system2.23103015
14MP0001529_abnormal_vocalization2.18214082
15MP0003718_maternal_effect2.13861582
16MP0005389_reproductive_system_phenotype2.06841248
17MP0003077_abnormal_cell_cycle2.03970915
18MP0002102_abnormal_ear_morphology1.91482146
19MP0005551_abnormal_eye_electrophysiolog1.87462628
20MP0003121_genomic_imprinting1.79614534
21MP0000427_abnormal_hair_cycle1.76522240
22MP0003693_abnormal_embryo_hatching1.72062544
23MP0003111_abnormal_nucleus_morphology1.71012107
24MP0002653_abnormal_ependyma_morphology1.62175125
25MP0000631_abnormal_neuroendocrine_gland1.60101105
26MP0003122_maternal_imprinting1.56101540
27MP0008789_abnormal_olfactory_epithelium1.51929427
28MP0004957_abnormal_blastocyst_morpholog1.51582086
29MP0002837_dystrophic_cardiac_calcinosis1.51049537
30MP0006276_abnormal_autonomic_nervous1.49961018
31MP0004270_analgesia1.47963832
32MP0002277_abnormal_respiratory_mucosa1.45680183
33MP0005253_abnormal_eye_physiology1.44185660
34MP0004133_heterotaxia1.42742469
35MP0000647_abnormal_sebaceous_gland1.39434977
36MP0002938_white_spotting1.39222106
37MP0003567_abnormal_fetal_cardiomyocyte1.35521187
38MP0000778_abnormal_nervous_system1.33194487
39MP0005379_endocrine/exocrine_gland_phen1.32192010
40MP0004142_abnormal_muscle_tone1.31342038
41MP0005084_abnormal_gallbladder_morpholo1.27111533
42MP0002751_abnormal_autonomic_nervous1.25958604
43MP0001929_abnormal_gametogenesis1.25348850
44MP0002210_abnormal_sex_determination1.24452676
45MP0003136_yellow_coat_color1.22640677
46MP0002928_abnormal_bile_duct1.20211395
47MP0008932_abnormal_embryonic_tissue1.17531903
48MP0002009_preneoplasia1.14480154
49MP0001984_abnormal_olfaction1.13181610
50MP0005645_abnormal_hypothalamus_physiol1.11119153
51MP0005499_abnormal_olfactory_system1.10261379
52MP0005394_taste/olfaction_phenotype1.10261379
53MP0000653_abnormal_sex_gland1.09378811
54MP0005391_vision/eye_phenotype1.09145381
55MP0004924_abnormal_behavior1.08171554
56MP0005386_behavior/neurological_phenoty1.08171554
57MP0008995_early_reproductive_senescence1.07277974
58MP0003698_abnormal_male_reproductive1.04419514
59MP0001145_abnormal_male_reproductive1.04018218
60MP0006035_abnormal_mitochondrial_morpho1.03074616
61MP0001764_abnormal_homeostasis1.00780297
62MP0005195_abnormal_posterior_eye1.00467982
63MP0008007_abnormal_cellular_replicative1.00372993
64MP0008872_abnormal_physiological_respon0.99470546
65MP0004043_abnormal_pH_regulation0.98932168
66MP0003937_abnormal_limbs/digits/tail_de0.98147645
67MP0009697_abnormal_copulation0.97959828
68MP0005410_abnormal_fertilization0.97375459
69MP0001119_abnormal_female_reproductive0.96518995
70MP0001188_hyperpigmentation0.95458764
71MP0001485_abnormal_pinna_reflex0.91215225
72MP0001286_abnormal_eye_development0.89909715
73MP0009745_abnormal_behavioral_response0.88525944
74MP0003786_premature_aging0.87324910
75MP0005646_abnormal_pituitary_gland0.86993346
76MP0003119_abnormal_digestive_system0.86703319
77MP0004197_abnormal_fetal_growth/weight/0.85771689
78MP0005085_abnormal_gallbladder_physiolo0.85178861
79MP0002233_abnormal_nose_morphology0.84926664
80MP0002638_abnormal_pupillary_reflex0.82451293
81MP0000358_abnormal_cell_content/0.81770801
82MP0000383_abnormal_hair_follicle0.78668695
83MP0001324_abnormal_eye_pigmentation0.78078156
84MP0005075_abnormal_melanosome_morpholog0.77993605
85MP0010307_abnormal_tumor_latency0.77684537
86MP0000569_abnormal_digit_pigmentation0.76424226
87MP0006054_spinal_hemorrhage0.76216817
88MP0002557_abnormal_social/conspecific_i0.76123310
89MP0001697_abnormal_embryo_size0.75157950
90MP0003861_abnormal_nervous_system0.73552731
91MP0001986_abnormal_taste_sensitivity0.73541741
92MP0002752_abnormal_somatic_nervous0.70691871
93MP0003943_abnormal_hepatobiliary_system0.68595953
94MP0002092_abnormal_eye_morphology0.68501682
95MP0002090_abnormal_vision0.67040425
96MP0002006_tumorigenesis0.66385378
97MP0000516_abnormal_urinary_system0.66384831
98MP0005367_renal/urinary_system_phenotyp0.66384831
99MP0008770_decreased_survivor_rate0.66071417
100MP0002876_abnormal_thyroid_physiology0.65758537

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)3.95155462
2Pancreatic cysts (HP:0001737)3.63563201
3Nephronophthisis (HP:0000090)3.47706127
4Abnormality of midbrain morphology (HP:0002418)3.40585600
5Molar tooth sign on MRI (HP:0002419)3.40585600
6Chronic hepatic failure (HP:0100626)3.35417578
73-Methylglutaconic aciduria (HP:0003535)3.24358310
8Volvulus (HP:0002580)3.21073940
9Abnormality of chromosome stability (HP:0003220)3.19506221
10Abnormality of the renal cortex (HP:0011035)3.01418633
11True hermaphroditism (HP:0010459)2.97854627
12Medial flaring of the eyebrow (HP:0010747)2.92701127
13Abnormality of the renal medulla (HP:0100957)2.92263702
14Nephrogenic diabetes insipidus (HP:0009806)2.87602961
15Intestinal atresia (HP:0011100)2.83701906
16Gastrointestinal atresia (HP:0002589)2.81682893
17Hyperglycinemia (HP:0002154)2.73571635
18Birth length less than 3rd percentile (HP:0003561)2.70138607
19Chromsome breakage (HP:0040012)2.67622808
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66365605
21Meckel diverticulum (HP:0002245)2.63520970
22Renal cortical cysts (HP:0000803)2.63088910
23Abnormality of the ileum (HP:0001549)2.62273867
24Abnormality of the labia minora (HP:0012880)2.59309839
25Genital tract atresia (HP:0001827)2.54818357
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.52481434
27Lissencephaly (HP:0001339)2.48795166
28Colon cancer (HP:0003003)2.43563275
29Congenital primary aphakia (HP:0007707)2.41397839
30Gait imbalance (HP:0002141)2.40876267
31Methylmalonic acidemia (HP:0002912)2.37797158
32Methylmalonic aciduria (HP:0012120)2.33273180
33Attenuation of retinal blood vessels (HP:0007843)2.26068269
34Abolished electroretinogram (ERG) (HP:0000550)2.25155113
35Pendular nystagmus (HP:0012043)2.24811167
36Vaginal atresia (HP:0000148)2.21774430
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.21129663
38Abnormality of the preputium (HP:0100587)2.18769718
39Tubulointerstitial nephritis (HP:0001970)2.13541144
40Congenital stationary night blindness (HP:0007642)2.10907767
41Sloping forehead (HP:0000340)2.10221664
42Type II lissencephaly (HP:0007260)2.09080430
43Hip dysplasia (HP:0001385)2.06615316
44Bony spicule pigmentary retinopathy (HP:0007737)2.01167667
45Abnormality of vitamin B metabolism (HP:0004340)2.00094828
46Postaxial foot polydactyly (HP:0001830)2.00044315
47Sclerocornea (HP:0000647)1.99702713
48Patellar aplasia (HP:0006443)1.98680539
49Aplasia/Hypoplasia of the tibia (HP:0005772)1.98281883
50Small intestinal stenosis (HP:0012848)1.97524435
51Duodenal stenosis (HP:0100867)1.97524435
52Abnormality of methionine metabolism (HP:0010901)1.95735723
53Tubular atrophy (HP:0000092)1.95364811
54Congenital hepatic fibrosis (HP:0002612)1.92281812
55Abnormality of macular pigmentation (HP:0008002)1.92268582
56Abnormal albumin level (HP:0012116)1.91682565
57Hypoalbuminemia (HP:0003073)1.91682565
58Aplasia/Hypoplasia of the patella (HP:0006498)1.88154347
59Clubbing of toes (HP:0100760)1.88060674
60Short tibia (HP:0005736)1.86730875
61Oligodactyly (hands) (HP:0001180)1.86397039
62Astigmatism (HP:0000483)1.85744680
63Increased CSF lactate (HP:0002490)1.85529490
64Pachygyria (HP:0001302)1.83783113
65Abnormal rod and cone electroretinograms (HP:0008323)1.82790416
66Abnormality of the duodenum (HP:0002246)1.81734620
67Retinal dysplasia (HP:0007973)1.80993359
68Abnormality of the vitamin B12 metabolism (HP:0004341)1.80365353
69Preaxial hand polydactyly (HP:0001177)1.79220407
70Optic nerve coloboma (HP:0000588)1.79164762
71Postaxial hand polydactyly (HP:0001162)1.78074259
72Broad-based gait (HP:0002136)1.77706455
73Bilateral microphthalmos (HP:0007633)1.74040849
74Acute necrotizing encephalopathy (HP:0006965)1.74004910
75Cerebellar dysplasia (HP:0007033)1.73619262
76Stomach cancer (HP:0012126)1.72204380
77Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71898661
78Abnormality of DNA repair (HP:0003254)1.71603219
79Nephroblastoma (Wilms tumor) (HP:0002667)1.71037905
80Dandy-Walker malformation (HP:0001305)1.70927029
81Anencephaly (HP:0002323)1.70487545
82Optic disc pallor (HP:0000543)1.70092731
83Increased serum lactate (HP:0002151)1.70062262
84Carpal bone hypoplasia (HP:0001498)1.69012248
85Hyperventilation (HP:0002883)1.68420258
86Acute encephalopathy (HP:0006846)1.67620139
87Broad foot (HP:0001769)1.67594920
88Progressive macrocephaly (HP:0004481)1.67337895
89Embryonal renal neoplasm (HP:0011794)1.66585673
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66363471
91Abnormality of alanine metabolism (HP:0010916)1.66363471
92Hyperalaninemia (HP:0003348)1.66363471
93Fibular aplasia (HP:0002990)1.66209003
94Poor coordination (HP:0002370)1.66038692
95Multicystic kidney dysplasia (HP:0000003)1.64971172
96Mitochondrial inheritance (HP:0001427)1.63635611
97Abnormal lung lobation (HP:0002101)1.63594932
98Abnormality of the pons (HP:0007361)1.62498059
99Male pseudohermaphroditism (HP:0000037)1.62453058
100Oculomotor apraxia (HP:0000657)1.62405424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.67739435
2ACVR1B3.50291409
3WNK33.11477726
4BRSK22.88801122
5FRK2.75414749
6TAF12.67830493
7BMPR1B2.58202962
8SRPK12.24307372
9NUAK12.21048489
10MKNK22.18477515
11ZAK2.15367687
12DYRK32.04107794
13YES12.03363028
14MKNK11.95841287
15PNCK1.87246433
16TSSK61.77989025
17WEE11.77944454
18IRAK11.76112100
19CAMKK21.72792274
20BUB11.65146740
21PLK31.61521518
22DYRK21.59816778
23PLK41.57582042
24TAOK31.56387050
25VRK11.55733136
26MUSK1.50876840
27TTK1.50722975
28MARK11.50545753
29CASK1.46713204
30TRIM281.44865255
31TLK11.43680532
32CDC71.42135006
33MAPK131.38895592
34IRAK21.36424402
35ERBB31.35681144
36BCR1.32951601
37BCKDK1.18716116
38MAP3K41.12981197
39EIF2AK31.12875951
40TNIK1.12154700
41PLK11.11531097
42BRSK11.02625635
43PBK1.02010821
44MAP2K61.01571876
45PIK3CG0.96548448
46NME10.87823216
47LATS10.85815468
48INSRR0.83656539
49MAP2K70.80940220
50CHEK20.80864823
51NEK20.77327951
52GRK10.76270738
53CSNK1G20.75860887
54ATR0.74744805
55ADRBK20.74304258
56NEK10.71790172
57EPHA40.71274036
58ATM0.70749457
59CDK30.69358470
60STK30.69274080
61TGFBR10.69162879
62CSNK1G10.63376900
63AURKB0.59251178
64FGFR20.58923033
65PRKCG0.55765317
66DYRK1A0.55535220
67STK240.54581056
68MAP3K120.54570457
69BRD40.53952918
70CSNK1G30.51311851
71NLK0.51183151
72PLK20.49938390
73EPHA30.49650135
74RPS6KA40.48416297
75PRKCE0.46464393
76PAK30.46462486
77CHEK10.42957847
78TEC0.42843949
79TIE10.42307732
80AURKA0.41866514
81RPS6KB20.41506232
82TAOK20.39886393
83CSNK1A1L0.38982480
84PASK0.38675031
85MINK10.37283432
86EIF2AK20.35994728
87STK40.35485254
88RPS6KA50.34767001
89STK160.32094871
90STK390.31983807
91CSNK1E0.31716133
92OXSR10.31567097
93PRKACB0.31369629
94MARK30.31158614
95SIK20.30878979
96CSNK2A20.30242894
97SIK30.29963950
98CCNB10.29460533
99MAPK150.29012277
100WNK40.28631958

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.29298347
2Non-homologous end-joining_Homo sapiens_hsa034502.95237815
3Mismatch repair_Homo sapiens_hsa034302.77271906
4Fanconi anemia pathway_Homo sapiens_hsa034602.76458584
5RNA degradation_Homo sapiens_hsa030182.62016384
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60568973
7Basal transcription factors_Homo sapiens_hsa030222.58900598
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53572224
9RNA polymerase_Homo sapiens_hsa030202.39387292
10Selenocompound metabolism_Homo sapiens_hsa004502.36052353
11DNA replication_Homo sapiens_hsa030302.24502848
12RNA transport_Homo sapiens_hsa030132.14577798
13Protein export_Homo sapiens_hsa030602.03261172
14Nucleotide excision repair_Homo sapiens_hsa034201.94197074
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91754351
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89587384
17Propanoate metabolism_Homo sapiens_hsa006401.88997529
18Phototransduction_Homo sapiens_hsa047441.88700169
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86723436
20Proteasome_Homo sapiens_hsa030501.81079349
21Spliceosome_Homo sapiens_hsa030401.77815976
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73490042
23Ether lipid metabolism_Homo sapiens_hsa005651.69166620
24Base excision repair_Homo sapiens_hsa034101.66505276
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66160196
26Vitamin digestion and absorption_Homo sapiens_hsa049771.62116326
27Cell cycle_Homo sapiens_hsa041101.61703750
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60289921
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58775607
30Oxidative phosphorylation_Homo sapiens_hsa001901.57651660
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57267404
32Linoleic acid metabolism_Homo sapiens_hsa005911.53620825
33Steroid biosynthesis_Homo sapiens_hsa001001.49724709
34mRNA surveillance pathway_Homo sapiens_hsa030151.45968350
35Parkinsons disease_Homo sapiens_hsa050121.42630051
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35447217
37Pyrimidine metabolism_Homo sapiens_hsa002401.27053726
38Purine metabolism_Homo sapiens_hsa002301.25616903
39Folate biosynthesis_Homo sapiens_hsa007901.23821997
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.22569681
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19914646
42Huntingtons disease_Homo sapiens_hsa050161.17738766
43Butanoate metabolism_Homo sapiens_hsa006501.17486292
44One carbon pool by folate_Homo sapiens_hsa006701.15967843
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10232222
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.05952761
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97946222
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92687632
49Circadian rhythm_Homo sapiens_hsa047100.92247334
50Ribosome_Homo sapiens_hsa030100.86986933
51Olfactory transduction_Homo sapiens_hsa047400.81789408
52Alzheimers disease_Homo sapiens_hsa050100.78691878
53Oocyte meiosis_Homo sapiens_hsa041140.78156913
54Nitrogen metabolism_Homo sapiens_hsa009100.77453393
55Caffeine metabolism_Homo sapiens_hsa002320.77123645
56Tryptophan metabolism_Homo sapiens_hsa003800.76502579
57Nicotine addiction_Homo sapiens_hsa050330.76495207
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75966222
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74995372
60Fatty acid elongation_Homo sapiens_hsa000620.74589253
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73646160
62p53 signaling pathway_Homo sapiens_hsa041150.72372521
63Hedgehog signaling pathway_Homo sapiens_hsa043400.67763933
64Regulation of autophagy_Homo sapiens_hsa041400.67665289
65Metabolic pathways_Homo sapiens_hsa011000.66316803
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65160724
67Peroxisome_Homo sapiens_hsa041460.64125662
68Pyruvate metabolism_Homo sapiens_hsa006200.63854765
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59686246
70Hippo signaling pathway_Homo sapiens_hsa043900.58820772
71Fat digestion and absorption_Homo sapiens_hsa049750.57301626
72Vitamin B6 metabolism_Homo sapiens_hsa007500.51131045
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48403138
74Taste transduction_Homo sapiens_hsa047420.47603827
75Sphingolipid metabolism_Homo sapiens_hsa006000.47478753
76Glycerolipid metabolism_Homo sapiens_hsa005610.45336885
77Primary immunodeficiency_Homo sapiens_hsa053400.44554352
78ABC transporters_Homo sapiens_hsa020100.40935228
79Arachidonic acid metabolism_Homo sapiens_hsa005900.39545776
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.37259713
81TGF-beta signaling pathway_Homo sapiens_hsa043500.36895322
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31601616
83Retinol metabolism_Homo sapiens_hsa008300.31591676
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31446270
85Sulfur relay system_Homo sapiens_hsa041220.30744604
86Epstein-Barr virus infection_Homo sapiens_hsa051690.30313648
87beta-Alanine metabolism_Homo sapiens_hsa004100.30292585
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29885022
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29360978
90Chemical carcinogenesis_Homo sapiens_hsa052040.29077076
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28491705
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27686809
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.27397907
94Basal cell carcinoma_Homo sapiens_hsa052170.26868312
95Fatty acid degradation_Homo sapiens_hsa000710.25024236
96Dopaminergic synapse_Homo sapiens_hsa047280.24870821
97Alcoholism_Homo sapiens_hsa050340.22616957
98Serotonergic synapse_Homo sapiens_hsa047260.22079335
99Wnt signaling pathway_Homo sapiens_hsa043100.21980561
100Morphine addiction_Homo sapiens_hsa050320.18015243

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