ZNF181

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.20046964
2DNA double-strand break processing (GO:0000729)4.30024788
3C4-dicarboxylate transport (GO:0015740)3.98160946
4DNA integration (GO:0015074)3.90219757
5polyol transport (GO:0015791)3.84200382
6presynaptic membrane assembly (GO:0097105)3.75690180
7coenzyme catabolic process (GO:0009109)3.66858540
8ether lipid metabolic process (GO:0046485)3.47144380
9negative regulation of DNA-dependent DNA replication (GO:2000104)3.45456271
10spermatid nucleus differentiation (GO:0007289)3.33451585
11presynaptic membrane organization (GO:0097090)3.28263564
12one-carbon compound transport (GO:0019755)3.22653731
13replication fork processing (GO:0031297)3.22639291
14positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20800740
15regulation of relaxation of muscle (GO:1901077)3.18655490
16regulation of Golgi to plasma membrane protein transport (GO:0042996)3.16270546
17regulation of meiosis I (GO:0060631)3.16168774
18nonmotile primary cilium assembly (GO:0035058)3.15207269
19histone H2A acetylation (GO:0043968)3.10312070
20branched-chain amino acid catabolic process (GO:0009083)3.07465718
21intraciliary transport (GO:0042073)3.01099460
22photoreceptor cell maintenance (GO:0045494)3.00469334
23protein neddylation (GO:0045116)2.95923912
24synapsis (GO:0007129)2.92978184
25peptidyl-histidine modification (GO:0018202)2.91951842
26regulation of skeletal muscle contraction (GO:0014819)2.90808505
27epithelial cell differentiation involved in kidney development (GO:0035850)2.88763743
28regulation of sarcomere organization (GO:0060297)2.87025588
29pyrimidine nucleobase catabolic process (GO:0006208)2.86862285
30negative regulation of DNA recombination (GO:0045910)2.85760088
31positive regulation of mitochondrial fission (GO:0090141)2.85484067
32regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.81716445
33short-chain fatty acid metabolic process (GO:0046459)2.78570288
34ubiquinone biosynthetic process (GO:0006744)2.76562160
35ubiquinone metabolic process (GO:0006743)2.73982450
36regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.67411141
37inositol phosphate catabolic process (GO:0071545)2.67377392
38cilium or flagellum-dependent cell motility (GO:0001539)2.66759992
39positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.65100296
40mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.65100296
41epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64924896
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63115776
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63115776
44cullin deneddylation (GO:0010388)2.60670623
45neural tube formation (GO:0001841)2.55627346
46microtubule severing (GO:0051013)2.55365285
47regulation of helicase activity (GO:0051095)2.54229247
48mitochondrial RNA metabolic process (GO:0000959)2.52612336
49lipid particle organization (GO:0034389)2.52163612
50regulation of acyl-CoA biosynthetic process (GO:0050812)2.50434395
51negative regulation of neurotransmitter transport (GO:0051589)2.49410315
52establishment of protein localization to Golgi (GO:0072600)2.49339406
53protein targeting to Golgi (GO:0000042)2.47798871
54neuronal action potential propagation (GO:0019227)2.47770485
55maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.47412770
56positive regulation of protein homodimerization activity (GO:0090073)2.47006739
57IMP biosynthetic process (GO:0006188)2.45296241
58forebrain morphogenesis (GO:0048853)2.43370889
59neuron cell-cell adhesion (GO:0007158)2.42772765
60regulation of cell communication by electrical coupling (GO:0010649)2.42560813
61branched-chain amino acid metabolic process (GO:0009081)2.41383214
62cilium assembly (GO:0042384)2.40880380
63regulation of penile erection (GO:0060405)2.40339007
64auditory receptor cell stereocilium organization (GO:0060088)2.39655746
65cilium organization (GO:0044782)2.39068545
66chromatin remodeling at centromere (GO:0031055)2.38977147
67otic vesicle formation (GO:0030916)2.38905357
68CENP-A containing nucleosome assembly (GO:0034080)2.38900854
69phosphorylated carbohydrate dephosphorylation (GO:0046838)2.38120752
70inositol phosphate dephosphorylation (GO:0046855)2.38120752
71reciprocal DNA recombination (GO:0035825)2.37986545
72reciprocal meiotic recombination (GO:0007131)2.37986545
73retinal cone cell development (GO:0046549)2.34888790
74inner ear receptor stereocilium organization (GO:0060122)2.34811601
75centriole replication (GO:0007099)2.33672082
76cilium morphogenesis (GO:0060271)2.33437225
77mismatch repair (GO:0006298)2.33436479
78regulation of telomere maintenance (GO:0032204)2.31788347
79telomere maintenance via telomerase (GO:0007004)2.31708600
80water-soluble vitamin biosynthetic process (GO:0042364)2.30274523
81protein ADP-ribosylation (GO:0006471)2.29978474
82nucleobase catabolic process (GO:0046113)2.29826669
83IMP metabolic process (GO:0046040)2.29777421
84cellular ketone body metabolic process (GO:0046950)2.28705683
85detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.26596260
86gamma-aminobutyric acid transport (GO:0015812)2.26282985
87L-serine metabolic process (GO:0006563)2.24938358
88transcription from mitochondrial promoter (GO:0006390)2.24897906
89negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.24015255
90apical protein localization (GO:0045176)2.23379459
91positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.23345722
92quinone metabolic process (GO:1901661)2.21619338
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.21305862
94translesion synthesis (GO:0019985)2.20852833
95retrograde transport, vesicle recycling within Golgi (GO:0000301)2.20808258
96regulation of coenzyme metabolic process (GO:0051196)2.20015291
97regulation of cofactor metabolic process (GO:0051193)2.20015291
98RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.19797501
99negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.18688099
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.18100190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.40427816
2GBX2_23144817_ChIP-Seq_PC3_Human3.34805465
3POU3F2_20337985_ChIP-ChIP_501MEL_Human3.27090417
4IGF1R_20145208_ChIP-Seq_DFB_Human3.17307248
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.15915724
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.10989986
7ZNF274_21170338_ChIP-Seq_K562_Hela3.10528440
8FUS_26573619_Chip-Seq_HEK293_Human2.96271601
9EZH2_22144423_ChIP-Seq_EOC_Human2.72828741
10TAF15_26573619_Chip-Seq_HEK293_Human2.67606759
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64882997
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63636262
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.49355309
14EWS_26573619_Chip-Seq_HEK293_Human2.48657940
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32870021
16P300_19829295_ChIP-Seq_ESCs_Human2.15856696
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14304334
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.10472485
19VDR_22108803_ChIP-Seq_LS180_Human2.04297509
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02141216
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.00625903
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85769493
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78135860
24OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75663366
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74101870
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72151011
27SMAD4_21799915_ChIP-Seq_A2780_Human1.71849067
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70732521
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69399767
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65893696
31IRF1_19129219_ChIP-ChIP_H3396_Human1.64327216
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60813805
33ELK1_19687146_ChIP-ChIP_HELA_Human1.59660093
34ER_23166858_ChIP-Seq_MCF-7_Human1.59360104
35CBP_20019798_ChIP-Seq_JUKART_Human1.58827284
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58827284
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58357270
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.55636341
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52188787
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51043768
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48517258
42* STAT3_23295773_ChIP-Seq_U87_Human1.47959897
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47159609
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40914492
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.39226569
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38626328
47VDR_23849224_ChIP-Seq_CD4+_Human1.36315957
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.35392438
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35106176
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33663683
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.32272912
52MYC_18940864_ChIP-ChIP_HL60_Human1.30874322
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.30500935
54RNF2_27304074_Chip-Seq_NSC_Mouse1.28802314
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28166893
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.27681726
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27296074
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27230063
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26777434
60TCF4_23295773_ChIP-Seq_U87_Human1.26523903
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25397576
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24657965
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24469474
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24448355
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23798948
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22665462
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19924707
68* EST1_17652178_ChIP-ChIP_JURKAT_Human1.17416823
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16976034
70TAL1_26923725_Chip-Seq_HPCs_Mouse1.16154128
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.15962299
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.14590838
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13291844
74SOX2_19829295_ChIP-Seq_ESCs_Human1.12253055
75NANOG_19829295_ChIP-Seq_ESCs_Human1.12253055
76TCF4_22108803_ChIP-Seq_LS180_Human1.12178580
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11840067
78RUNX2_22187159_ChIP-Seq_PCA_Human1.11280278
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09407936
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08684783
81BCAT_22108803_ChIP-Seq_LS180_Human1.08589754
82P53_22387025_ChIP-Seq_ESCs_Mouse1.08486284
83AR_25329375_ChIP-Seq_VCAP_Human1.08145363
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07634792
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07418369
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07116596
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07116596
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05987877
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.05755116
90CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04784103
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02769864
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.02073954
93NFE2_27457419_Chip-Seq_LIVER_Mouse0.99531807
94P300_18555785_Chip-Seq_ESCs_Mouse0.97079587
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96749963
96CDX2_22108803_ChIP-Seq_LS180_Human0.96654010
97JUN_21703547_ChIP-Seq_K562_Human0.96144467
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93258605
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.93195002
100SOX2_21211035_ChIP-Seq_LN229_Gbm0.92856274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy3.39338282
2MP0001188_hyperpigmentation2.72968887
3MP0001984_abnormal_olfaction2.70824302
4MP0008058_abnormal_DNA_repair2.65139953
5MP0004147_increased_porphyrin_level2.61572869
6MP0008877_abnormal_DNA_methylation2.53313314
7MP0002102_abnormal_ear_morphology2.41334334
8MP0003646_muscle_fatigue2.25313074
9MP0004270_analgesia2.16362809
10MP0004145_abnormal_muscle_electrophysio2.16020036
11MP0002837_dystrophic_cardiac_calcinosis1.98458830
12MP0002009_preneoplasia1.97754302
13MP0006292_abnormal_olfactory_placode1.86474920
14MP0002736_abnormal_nociception_after1.75856795
15MP0002735_abnormal_chemical_nociception1.75622625
16MP0000516_abnormal_urinary_system1.72351546
17MP0005367_renal/urinary_system_phenotyp1.72351546
18MP0000751_myopathy1.63864930
19MP0003880_abnormal_central_pattern1.59809879
20MP0005084_abnormal_gallbladder_morpholo1.57295325
21MP0002638_abnormal_pupillary_reflex1.56673839
22MP0005551_abnormal_eye_electrophysiolog1.54626980
23MP0000749_muscle_degeneration1.53573379
24MP0005187_abnormal_penis_morphology1.52464675
25MP0004043_abnormal_pH_regulation1.51624074
26MP0001968_abnormal_touch/_nociception1.50515312
27MP0001529_abnormal_vocalization1.49655043
28MP0003567_abnormal_fetal_cardiomyocyte1.49482205
29MP0002160_abnormal_reproductive_system1.48824252
30MP0004215_abnormal_myocardial_fiber1.47776371
31MP0002234_abnormal_pharynx_morphology1.41203281
32MP0006276_abnormal_autonomic_nervous1.40780724
33MP0004885_abnormal_endolymph1.40303714
34MP0004142_abnormal_muscle_tone1.38420819
35MP0003718_maternal_effect1.36418951
36MP0004484_altered_response_of1.35944257
37MP0003221_abnormal_cardiomyocyte_apopto1.35467785
38MP0004859_abnormal_synaptic_plasticity1.32341798
39MP0009745_abnormal_behavioral_response1.30988989
40MP0005253_abnormal_eye_physiology1.29659937
41MP0010094_abnormal_chromosome_stability1.26707558
42MP0001486_abnormal_startle_reflex1.25807710
43MP0000778_abnormal_nervous_system1.23891123
44MP0003635_abnormal_synaptic_transmissio1.20744734
45MP0004134_abnormal_chest_morphology1.19765192
46MP0008007_abnormal_cellular_replicative1.18274009
47MP0009046_muscle_twitch1.16918220
48MP0003937_abnormal_limbs/digits/tail_de1.15867183
49MP0002734_abnormal_mechanical_nocicepti1.14677919
50MP0006036_abnormal_mitochondrial_physio1.12060941
51MP0005646_abnormal_pituitary_gland1.11251760
52MP0000049_abnormal_middle_ear1.09963437
53MP0003698_abnormal_male_reproductive1.08874814
54MP0001929_abnormal_gametogenesis1.08836083
55MP0008789_abnormal_olfactory_epithelium1.08343546
56MP0002272_abnormal_nervous_system1.08308906
57MP0000631_abnormal_neuroendocrine_gland1.07297499
58MP0001293_anophthalmia1.06842850
59MP0001764_abnormal_homeostasis1.02892960
60MP0002928_abnormal_bile_duct1.02429126
61MP0003011_delayed_dark_adaptation1.00377371
62MP0003787_abnormal_imprinting0.98713306
63MP0002063_abnormal_learning/memory/cond0.96519453
64MP0002396_abnormal_hematopoietic_system0.96188315
65MP0004036_abnormal_muscle_relaxation0.95840854
66MP0000569_abnormal_digit_pigmentation0.95729709
67MP0005248_abnormal_Harderian_gland0.95337059
68MP0005645_abnormal_hypothalamus_physiol0.95136331
69MP0004084_abnormal_cardiac_muscle0.94589630
70MP0001661_extended_life_span0.94133316
71MP0005394_taste/olfaction_phenotype0.94064048
72MP0005499_abnormal_olfactory_system0.94064048
73MP0002106_abnormal_muscle_physiology0.92158753
74MP0005075_abnormal_melanosome_morpholog0.92035639
75MP0006072_abnormal_retinal_apoptosis0.91999120
76MP0002269_muscular_atrophy0.91433315
77MP0004742_abnormal_vestibular_system0.91393950
78MP0003943_abnormal_hepatobiliary_system0.90647691
79MP0002572_abnormal_emotion/affect_behav0.89457211
80MP0003890_abnormal_embryonic-extraembry0.85575721
81MP0000647_abnormal_sebaceous_gland0.85411492
82MP0003121_genomic_imprinting0.85000432
83MP0003119_abnormal_digestive_system0.83738282
84MP0005620_abnormal_muscle_contractility0.83624904
85MP0000013_abnormal_adipose_tissue0.83457149
86MP0005410_abnormal_fertilization0.82846495
87MP0005386_behavior/neurological_phenoty0.82168171
88MP0004924_abnormal_behavior0.82168171
89MP0005423_abnormal_somatic_nervous0.81596312
90MP0005389_reproductive_system_phenotype0.80190038
91MP0005220_abnormal_exocrine_pancreas0.79998115
92MP0002067_abnormal_sensory_capabilities0.78867203
93MP0004085_abnormal_heartbeat0.78847844
94MP0001270_distended_abdomen0.77925908
95MP0003137_abnormal_impulse_conducting0.76551522
96MP0001879_abnormal_lymphatic_vessel0.76023082
97MP0002064_seizures0.75625525
98MP0002752_abnormal_somatic_nervous0.75468543
99MP0002972_abnormal_cardiac_muscle0.74624177
100MP0003122_maternal_imprinting0.74502791

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)3.71969894
2Absent rod-and cone-mediated responses on ERG (HP:0007688)3.47852414
3Dynein arm defect of respiratory motile cilia (HP:0012255)3.34000711
4Absent/shortened dynein arms (HP:0200106)3.34000711
5Colon cancer (HP:0003003)3.17536083
6Abnormality of glycine metabolism (HP:0010895)3.05389496
7Abnormality of serine family amino acid metabolism (HP:0010894)3.05389496
8Abnormal biliary tract physiology (HP:0012439)2.95417814
9Bile duct proliferation (HP:0001408)2.95417814
10Abnormal ciliary motility (HP:0012262)2.90150818
11Calf muscle hypertrophy (HP:0008981)2.89055984
12Abnormality of the labia minora (HP:0012880)2.85681587
13Hyperglycinuria (HP:0003108)2.80979244
14Muscle hypertrophy of the lower extremities (HP:0008968)2.78777770
15Exercise-induced muscle cramps (HP:0003710)2.78087408
16Pancreatic fibrosis (HP:0100732)2.69023578
17Medial flaring of the eyebrow (HP:0010747)2.65117004
18True hermaphroditism (HP:0010459)2.64982185
19Molar tooth sign on MRI (HP:0002419)2.61150478
20Abnormality of midbrain morphology (HP:0002418)2.61150478
21Progressive inability to walk (HP:0002505)2.58262051
22Abnormal rod and cone electroretinograms (HP:0008323)2.58180148
23Pancreatic cysts (HP:0001737)2.53233739
24Methylmalonic acidemia (HP:0002912)2.52726866
25Type II lissencephaly (HP:0007260)2.52127202
26Attenuation of retinal blood vessels (HP:0007843)2.50637138
27Tubulointerstitial nephritis (HP:0001970)2.50427699
28Rimmed vacuoles (HP:0003805)2.47469186
29Gait imbalance (HP:0002141)2.44846559
30Abolished electroretinogram (ERG) (HP:0000550)2.42844473
31Congenital primary aphakia (HP:0007707)2.39927810
32Abnormal respiratory motile cilium morphology (HP:0005938)2.33821445
33Abnormal respiratory epithelium morphology (HP:0012253)2.33821445
34Chronic hepatic failure (HP:0100626)2.33011323
35Retinal dysplasia (HP:0007973)2.26907586
36Nephronophthisis (HP:0000090)2.26376061
37Nephrogenic diabetes insipidus (HP:0009806)2.25908244
38Decreased central vision (HP:0007663)2.23790526
39Muscle fiber inclusion bodies (HP:0100299)2.22686205
40Cortical dysplasia (HP:0002539)2.21316198
41Polyphagia (HP:0002591)2.20946098
42Hepatoblastoma (HP:0002884)2.20192419
43Abnormality of serum amino acid levels (HP:0003112)2.19430588
44Supernumerary spleens (HP:0009799)2.16491196
45Abnormal respiratory motile cilium physiology (HP:0012261)2.15349386
46Renal cortical cysts (HP:0000803)2.14652116
47Genital tract atresia (HP:0001827)2.14096353
48Abnormality of the calf musculature (HP:0001430)2.13350273
49Febrile seizures (HP:0002373)2.12895514
50Medulloblastoma (HP:0002885)2.12223454
51Gonadotropin excess (HP:0000837)2.11271851
52Abnormality of macular pigmentation (HP:0008002)2.11034932
53Neoplasm of the adrenal cortex (HP:0100641)2.10265096
54Hemiparesis (HP:0001269)2.08338780
55Subaortic stenosis (HP:0001682)2.07907810
56Abnormality of the left ventricular outflow tract (HP:0011103)2.07907810
57Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.05534341
58Abnormality of chromosome stability (HP:0003220)2.04342579
59Distal arthrogryposis (HP:0005684)2.00500752
60Papillary thyroid carcinoma (HP:0002895)2.00333729
61Postaxial foot polydactyly (HP:0001830)1.99657823
62Inability to walk (HP:0002540)1.97726806
63Nemaline bodies (HP:0003798)1.97401791
64Vaginal atresia (HP:0000148)1.95898804
65Urinary urgency (HP:0000012)1.95873207
66Hyperventilation (HP:0002883)1.94709837
67Abnormality of the vitamin B12 metabolism (HP:0004341)1.94663340
68Broad-based gait (HP:0002136)1.93249626
69Astrocytoma (HP:0009592)1.91565395
70Abnormality of the astrocytes (HP:0100707)1.91565395
71Impaired vibration sensation in the lower limbs (HP:0002166)1.90806577
72Exercise-induced myalgia (HP:0003738)1.89404134
73Aplasia/Hypoplasia of the tongue (HP:0010295)1.89145280
74Neoplasm of the small intestine (HP:0100833)1.88125649
75Long clavicles (HP:0000890)1.87951860
76Lissencephaly (HP:0001339)1.87650239
77Ketoacidosis (HP:0001993)1.87492586
78Shoulder girdle muscle weakness (HP:0003547)1.86276922
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86236694
80Abnormality of alanine metabolism (HP:0010916)1.86236694
81Hyperalaninemia (HP:0003348)1.86236694
82Abnormality of vitamin B metabolism (HP:0004340)1.81677540
83Abnormality of the hip-girdle musculature (HP:0001445)1.81607245
84Abnormality of the musculature of the pelvis (HP:0001469)1.81607245
85Abnormality of the renal medulla (HP:0100957)1.80594843
86Drooling (HP:0002307)1.80015357
87Abnormal hair whorl (HP:0010721)1.79951828
88Sensorimotor neuropathy (HP:0007141)1.78798807
89Aplasia/Hypoplasia of the tibia (HP:0005772)1.77255774
90Thyroid carcinoma (HP:0002890)1.76881644
91Sloping forehead (HP:0000340)1.73841052
92Bifid tongue (HP:0010297)1.72777068
93Bundle branch block (HP:0011710)1.72487053
943-Methylglutaconic aciduria (HP:0003535)1.70706500
95Epidermoid cyst (HP:0200040)1.69591356
96Scrotal hypoplasia (HP:0000046)1.69163869
97Short tibia (HP:0005736)1.69154938
98Optic nerve hypoplasia (HP:0000609)1.67231014
99Postaxial hand polydactyly (HP:0001162)1.67038297
100Failure to thrive in infancy (HP:0001531)1.66503165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.80902748
2MAP4K23.36940551
3OBSCN2.99823539
4CDK192.71019435
5MAP3K42.65251442
6MAPK132.62579863
7CASK2.55043360
8ERBB32.50077952
9TRIM282.37944217
10TNIK2.11042073
11BMPR1B2.02752344
12BCKDK2.01564939
13WNK31.92147958
14CSNK1G21.85357476
15TAF11.84700278
16PINK11.83614780
17CSNK1G11.81619316
18NUAK11.79888098
19CSNK1G31.76304012
20PHKG21.69539938
21PHKG11.69539938
22CSNK1A1L1.68530900
23NEK11.59866927
24MARK11.58347157
25MKNK21.57693262
26BCR1.54822208
27PRKD31.52824549
28ACVR1B1.36264077
29MKNK11.35622471
30MAP2K41.28700382
31RPS6KA41.27975536
32VRK11.27561727
33MAP2K71.14253559
34STK38L1.06492318
35LATS11.05416227
36SRPK11.02479968
37OXSR10.99279406
38PLK30.96407255
39INSRR0.92560113
40PRKCE0.91059711
41PLK20.90786396
42BRD40.90302228
43ZAK0.89735595
44MAP3K60.89653410
45EIF2AK30.86174225
46TTK0.84768022
47DYRK20.84245233
48NTRK20.83213369
49WEE10.81001704
50PLK10.80503951
51FLT30.78578323
52DYRK30.76858456
53SGK20.76308460
54TSSK60.76134533
55CCNB10.73122367
56KIT0.72349477
57DYRK1A0.72098184
58AKT30.71789526
59STK390.70294771
60ADRBK20.67803844
61TAOK30.67680664
62FGFR20.66007237
63PAK30.65849594
64DAPK20.65505565
65EPHA30.64049447
66CAMK2A0.63833553
67MINK10.63310306
68CAMK40.61642724
69NTRK30.59380342
70CDK30.58224923
71ATM0.58048276
72CSNK1D0.57133010
73GRK10.56933847
74PRKCG0.56373874
75BRSK20.56341169
76MATK0.54768794
77RPS6KB10.53689363
78ATR0.53215610
79UHMK10.52539402
80EPHA40.49023781
81PRKG10.48236064
82KSR10.47934001
83PNCK0.45373314
84CDC70.44440212
85NLK0.44292579
86SGK2230.44234805
87SGK4940.44234805
88CAMK2D0.44062330
89PRKACB0.43439638
90PDK20.41533738
91MAP3K50.40280840
92RPS6KA50.39890211
93PRKACA0.39021997
94CDK50.36117913
95PKN10.35942722
96MUSK0.35876587
97FER0.35421071
98CSNK1E0.34996233
99PRKCZ0.33771318
100CAMK2B0.32666542

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.61945514
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.02615009
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.96351282
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.32015964
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31477192
6Butanoate metabolism_Homo sapiens_hsa006502.25598507
7Fanconi anemia pathway_Homo sapiens_hsa034602.23292547
8Basal transcription factors_Homo sapiens_hsa030222.01461992
9Homologous recombination_Homo sapiens_hsa034401.91452510
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90237490
11Peroxisome_Homo sapiens_hsa041461.83107641
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82173311
13Non-homologous end-joining_Homo sapiens_hsa034501.80240293
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70610798
15Steroid biosynthesis_Homo sapiens_hsa001001.68394171
16RNA degradation_Homo sapiens_hsa030181.63421162
17Protein export_Homo sapiens_hsa030601.60520671
18Nicotine addiction_Homo sapiens_hsa050331.54532980
19Fatty acid degradation_Homo sapiens_hsa000711.49653099
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49045224
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.46671277
22Fatty acid metabolism_Homo sapiens_hsa012121.45109771
23Fatty acid elongation_Homo sapiens_hsa000621.42688130
24RNA transport_Homo sapiens_hsa030131.32750864
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30931490
26Base excision repair_Homo sapiens_hsa034101.30065359
27Linoleic acid metabolism_Homo sapiens_hsa005911.28663170
28Caffeine metabolism_Homo sapiens_hsa002321.28082963
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23777163
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21441709
31Mismatch repair_Homo sapiens_hsa034301.18803619
32mRNA surveillance pathway_Homo sapiens_hsa030151.16143110
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13781799
34Ether lipid metabolism_Homo sapiens_hsa005651.13516312
35Circadian entrainment_Homo sapiens_hsa047131.12252111
36Pyruvate metabolism_Homo sapiens_hsa006201.10887117
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09179909
38Olfactory transduction_Homo sapiens_hsa047401.08883686
39Oocyte meiosis_Homo sapiens_hsa041141.08269430
40GABAergic synapse_Homo sapiens_hsa047271.07289057
41Phototransduction_Homo sapiens_hsa047441.06945068
42Circadian rhythm_Homo sapiens_hsa047101.06674149
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06264158
44Long-term depression_Homo sapiens_hsa047301.04721519
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03755735
46Renin secretion_Homo sapiens_hsa049241.00783566
47Regulation of autophagy_Homo sapiens_hsa041401.00063022
48Nitrogen metabolism_Homo sapiens_hsa009100.98677861
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97007933
50Nucleotide excision repair_Homo sapiens_hsa034200.96808223
51Selenocompound metabolism_Homo sapiens_hsa004500.95197837
52Dopaminergic synapse_Homo sapiens_hsa047280.93967600
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.92155363
54Glutamatergic synapse_Homo sapiens_hsa047240.90762321
55Carbon metabolism_Homo sapiens_hsa012000.89797919
56Taste transduction_Homo sapiens_hsa047420.89330842
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88880910
58Purine metabolism_Homo sapiens_hsa002300.88415188
59Morphine addiction_Homo sapiens_hsa050320.86437490
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86418634
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85761144
62beta-Alanine metabolism_Homo sapiens_hsa004100.85608869
63Arachidonic acid metabolism_Homo sapiens_hsa005900.82332760
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80852218
65Dorso-ventral axis formation_Homo sapiens_hsa043200.76100601
66Amphetamine addiction_Homo sapiens_hsa050310.71353767
67Cardiac muscle contraction_Homo sapiens_hsa042600.71304198
68RNA polymerase_Homo sapiens_hsa030200.71134005
69Retinol metabolism_Homo sapiens_hsa008300.70565528
70Salivary secretion_Homo sapiens_hsa049700.69625061
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67184859
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67094465
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65583417
74Insulin secretion_Homo sapiens_hsa049110.63875645
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62034269
76Vitamin B6 metabolism_Homo sapiens_hsa007500.61536529
77Folate biosynthesis_Homo sapiens_hsa007900.60624051
78Tryptophan metabolism_Homo sapiens_hsa003800.60098358
79Chemical carcinogenesis_Homo sapiens_hsa052040.59749259
80Metabolic pathways_Homo sapiens_hsa011000.58720682
81Glucagon signaling pathway_Homo sapiens_hsa049220.57386260
82Spliceosome_Homo sapiens_hsa030400.57210551
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56650550
84Gap junction_Homo sapiens_hsa045400.54102346
85Parkinsons disease_Homo sapiens_hsa050120.53802818
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.53520657
87Serotonergic synapse_Homo sapiens_hsa047260.52837582
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51704006
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.50743985
90Calcium signaling pathway_Homo sapiens_hsa040200.48209428
91Fat digestion and absorption_Homo sapiens_hsa049750.47871022
92Cell cycle_Homo sapiens_hsa041100.46151472
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45646996
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.44862524
95Arginine and proline metabolism_Homo sapiens_hsa003300.44834265
96Cocaine addiction_Homo sapiens_hsa050300.43657332
97Oxytocin signaling pathway_Homo sapiens_hsa049210.42434726
98ABC transporters_Homo sapiens_hsa020100.41535453
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40085313
100Gastric acid secretion_Homo sapiens_hsa049710.38274463

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