ZNF182

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)6.35723061
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.40843807
3negative regulation of cell killing (GO:0031342)5.40843807
4resolution of meiotic recombination intermediates (GO:0000712)5.36634163
5positive regulation of gamma-delta T cell activation (GO:0046645)4.71490936
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.65949353
7inositol phosphate catabolic process (GO:0071545)4.55287267
8neural tube formation (GO:0001841)4.48895356
9inositol phosphate dephosphorylation (GO:0046855)4.18877088
10phosphorylated carbohydrate dephosphorylation (GO:0046838)4.18877088
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07749927
12regulation of B cell receptor signaling pathway (GO:0050855)3.86170318
13protein prenylation (GO:0018342)3.84121520
14prenylation (GO:0097354)3.84121520
15phosphatidylinositol dephosphorylation (GO:0046856)3.73432839
16mitotic sister chromatid cohesion (GO:0007064)3.56356782
17phospholipid dephosphorylation (GO:0046839)3.53921078
18polyol catabolic process (GO:0046174)3.53373307
19cellular ketone body metabolic process (GO:0046950)3.48873193
20establishment of chromosome localization (GO:0051303)3.48804083
21negative regulation of DNA recombination (GO:0045910)3.45124227
22meiotic chromosome segregation (GO:0045132)3.44476285
23metaphase plate congression (GO:0051310)3.32389060
24negative regulation of T cell mediated immunity (GO:0002710)3.32374277
25B cell receptor signaling pathway (GO:0050853)3.29449596
26negative regulation of lymphocyte mediated immunity (GO:0002707)3.25376932
27response to interleukin-15 (GO:0070672)3.21557180
28hepatocyte apoptotic process (GO:0097284)3.20985218
29protein localization to kinetochore (GO:0034501)3.18468771
30regulation of gamma-delta T cell activation (GO:0046643)3.17073910
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16724404
32regulation of gamma-delta T cell differentiation (GO:0045586)3.14156009
33regulation of cilium movement (GO:0003352)3.10040640
34cellular response to interleukin-15 (GO:0071350)3.08447806
35attachment of spindle microtubules to kinetochore (GO:0008608)3.07216664
36regulation of fibroblast apoptotic process (GO:2000269)3.04111657
37valine metabolic process (GO:0006573)3.03539587
38ketone body metabolic process (GO:1902224)2.98888176
39mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.96542773
40positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.96542773
41antigen processing and presentation of endogenous antigen (GO:0019883)2.95604449
42peptidyl-lysine trimethylation (GO:0018023)2.95240113
43microtubule anchoring (GO:0034453)2.93687264
44mRNA modification (GO:0016556)2.91293127
45N-terminal protein amino acid acetylation (GO:0006474)2.90954602
46positive regulation of granulocyte differentiation (GO:0030854)2.86778783
47regulation of regulatory T cell differentiation (GO:0045589)2.83213618
48centriole replication (GO:0007099)2.82965111
49protein localization to chromosome, centromeric region (GO:0071459)2.80603810
50nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.80022129
51histone H3-K4 methylation (GO:0051568)2.78797270
52histone phosphorylation (GO:0016572)2.78377439
53histone H3-K4 trimethylation (GO:0080182)2.77742475
54cellular extravasation (GO:0045123)2.77521115
55positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75862614
56regulation of B cell differentiation (GO:0045577)2.73955103
57production of molecular mediator involved in inflammatory response (GO:0002532)2.73684053
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73598396
59cytochrome complex assembly (GO:0017004)2.72920326
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72389625
61regulation of memory T cell differentiation (GO:0043380)2.71856199
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71208397
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.70253667
64neutrophil activation involved in immune response (GO:0002283)2.69731683
65modulation by symbiont of host defense response (GO:0052031)2.68877619
66modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68877619
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68877619
68positive regulation by organism of defense response of other organism involved in symbiotic interact2.68877619
69modulation by symbiont of host immune response (GO:0052553)2.68877619
70positive regulation by symbiont of host defense response (GO:0052509)2.68877619
71negative T cell selection (GO:0043383)2.68467853
72detection of other organism (GO:0098543)2.66752060
73regulation of histone H3-K27 methylation (GO:0061085)2.64608576
74positive regulation of histone H3-K4 methylation (GO:0051571)2.62810755
75negative regulation of execution phase of apoptosis (GO:1900118)2.58039961
76negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.57391466
77negative regulation of phagocytosis (GO:0050765)2.57327305
78chromosome organization involved in meiosis (GO:0070192)2.56957353
79regulation of alpha-beta T cell proliferation (GO:0046640)2.56791998
80positive regulation of B cell differentiation (GO:0045579)2.55953784
81interkinetic nuclear migration (GO:0022027)2.54857658
82regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.54310339
83nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50072388
84negative regulation of leukocyte mediated immunity (GO:0002704)2.49929044
85detection of bacterium (GO:0016045)2.48774727
86positive T cell selection (GO:0043368)2.48200168
87phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.47585535
88brain morphogenesis (GO:0048854)2.46803806
89somite rostral/caudal axis specification (GO:0032525)2.46447863
90response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.46423601
91response to host immune response (GO:0052572)2.46423601
92B cell proliferation (GO:0042100)2.45428088
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.45296979
94regulation of isotype switching to IgG isotypes (GO:0048302)2.44644732
95negative regulation of T-helper cell differentiation (GO:0045623)2.43397819
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.43397819
97sister chromatid cohesion (GO:0007062)2.42835463
98somatic diversification of immune receptors via somatic mutation (GO:0002566)2.42716027
99somatic hypermutation of immunoglobulin genes (GO:0016446)2.42716027
100neutrophil activation (GO:0042119)2.42561072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.26435528
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.69804643
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.29501547
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.24371116
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.14966090
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.94939998
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46803684
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.43212665
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40105656
10VDR_22108803_ChIP-Seq_LS180_Human2.36481565
11CIITA_25753668_ChIP-Seq_RAJI_Human2.33151937
12MYB_26560356_Chip-Seq_TH2_Human2.29926898
13PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27667895
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.23456958
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18397838
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.17762505
17FOXP3_21729870_ChIP-Seq_TREG_Human2.15428796
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.10563542
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07587344
20* ZNF274_21170338_ChIP-Seq_K562_Hela2.06967772
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.06374158
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01203677
23VDR_23849224_ChIP-Seq_CD4+_Human1.97231594
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96737119
25ELK1_19687146_ChIP-ChIP_HELA_Human1.96365405
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93533623
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.90883345
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85964297
29IGF1R_20145208_ChIP-Seq_DFB_Human1.85840020
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82194206
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81621880
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.81201810
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80159422
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79076677
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75220907
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74957861
37* SPI1_23547873_ChIP-Seq_NB4_Human1.74701433
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72768637
39MYB_26560356_Chip-Seq_TH1_Human1.70984358
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.69848631
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68320665
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64910417
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64465694
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58568075
45GATA3_27048872_Chip-Seq_THYMUS_Human1.58562971
46EWS_26573619_Chip-Seq_HEK293_Human1.57069059
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52094514
48GATA3_26560356_Chip-Seq_TH2_Human1.49126855
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.48720975
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48060992
51RUNX_20019798_ChIP-Seq_JUKART_Human1.45764740
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40793438
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34002034
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32202072
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.31111310
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29989307
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27967743
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26534076
59FUS_26573619_Chip-Seq_HEK293_Human1.22363952
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22056287
61E2F7_22180533_ChIP-Seq_HELA_Human1.22021429
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20533243
63IRF1_19129219_ChIP-ChIP_H3396_Human1.19842757
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15421626
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.14071130
66TAF15_26573619_Chip-Seq_HEK293_Human1.12327140
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.11654000
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.09590458
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07220013
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04482760
71ETS1_20019798_ChIP-Seq_JURKAT_Human1.03848740
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01563429
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01319369
74WT1_19549856_ChIP-ChIP_CCG9911_Human0.98945729
75ER_23166858_ChIP-Seq_MCF-7_Human0.98646791
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97526290
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96263445
78SALL4_22934838_ChIP-ChIP_CD34+_Human0.95655857
79TP53_22573176_ChIP-Seq_HFKS_Human0.94523225
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93862556
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93644964
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92817438
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92577582
84MYC_22102868_ChIP-Seq_BL_Human0.91008520
85PU_27001747_Chip-Seq_BMDM_Mouse0.89985672
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89537474
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89046784
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88381649
89CBP_20019798_ChIP-Seq_JUKART_Human0.88381649
90GBX2_23144817_ChIP-Seq_PC3_Human0.87679435
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87189619
92UTX_26944678_Chip-Seq_JUKART_Human0.86820699
93YY1_21170310_ChIP-Seq_MESCs_Mouse0.86729601
94TFEB_21752829_ChIP-Seq_HELA_Human0.86542235
95SMRT_27268052_Chip-Seq_Bcells_Human0.85742222
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84499776
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84090127
98KDM5A_27292631_Chip-Seq_BREAST_Human0.82830909
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82704417
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81990197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.54002847
2MP0003787_abnormal_imprinting3.25658170
3MP0008877_abnormal_DNA_methylation3.11694186
4MP0005671_abnormal_response_to2.78386487
5MP0001835_abnormal_antigen_presentation2.76546839
6MP0002132_abnormal_respiratory_system2.67158212
7MP0002396_abnormal_hematopoietic_system2.35292010
8MP0001800_abnormal_humoral_immune2.28193666
9MP0002139_abnormal_hepatobiliary_system2.20667145
10MP0003436_decreased_susceptibility_to2.18585913
11MP0003763_abnormal_thymus_physiology2.13392959
12MP0001984_abnormal_olfaction1.98050121
13MP0002723_abnormal_immune_serum1.97546545
14MP0008789_abnormal_olfactory_epithelium1.91892997
15MP0002452_abnormal_antigen_presenting1.91288887
16MP0002398_abnormal_bone_marrow1.90931046
17MP0002420_abnormal_adaptive_immunity1.89243304
18MP0001819_abnormal_immune_cell1.88962718
19MP0005000_abnormal_immune_tolerance1.87239249
20MP0000689_abnormal_spleen_morphology1.86528921
21MP0003724_increased_susceptibility_to1.80706728
22MP0005397_hematopoietic_system_phenotyp1.80269141
23MP0001545_abnormal_hematopoietic_system1.80269141
24MP0005394_taste/olfaction_phenotype1.76001492
25MP0005499_abnormal_olfactory_system1.76001492
26MP0009785_altered_susceptibility_to1.74830335
27MP0002009_preneoplasia1.73963258
28MP0000703_abnormal_thymus_morphology1.71574396
29MP0003303_peritoneal_inflammation1.69663203
30MP0003656_abnormal_erythrocyte_physiolo1.64637791
31MP0003183_abnormal_peptide_metabolism1.63504893
32MP0005387_immune_system_phenotype1.63160686
33MP0001790_abnormal_immune_system1.63160686
34MP0000716_abnormal_immune_system1.62295876
35MP0000685_abnormal_immune_system1.60505848
36MP0002419_abnormal_innate_immunity1.59889182
37MP0008058_abnormal_DNA_repair1.59217677
38MP0008260_abnormal_autophagy1.58522288
39MP0002722_abnormal_immune_system1.55407004
40MP0003718_maternal_effect1.53452549
41MP0002166_altered_tumor_susceptibility1.51287704
42MP0003077_abnormal_cell_cycle1.49305085
43MP0005075_abnormal_melanosome_morpholog1.48957410
44MP0003221_abnormal_cardiomyocyte_apopto1.47360912
45MP0005025_abnormal_response_to1.46759403
46MP0003121_genomic_imprinting1.42003128
47MP0002405_respiratory_system_inflammati1.40091713
48MP0003890_abnormal_embryonic-extraembry1.36214420
49MP0002102_abnormal_ear_morphology1.34490666
50MP0004883_abnormal_blood_vessel1.33781843
51MP0000372_irregular_coat_pigmentation1.29166330
52MP0002429_abnormal_blood_cell1.28543388
53MP0001853_heart_inflammation1.28305501
54MP0001986_abnormal_taste_sensitivity1.22488574
55MP0003111_abnormal_nucleus_morphology1.17689226
56MP0004381_abnormal_hair_follicle1.17328971
57MP0000569_abnormal_digit_pigmentation1.17206061
58MP0002928_abnormal_bile_duct1.16494543
59MP0010094_abnormal_chromosome_stability1.15731787
60MP0004808_abnormal_hematopoietic_stem1.14233533
61MP0006276_abnormal_autonomic_nervous1.12262417
62MP0001661_extended_life_span1.12196061
63MP0006054_spinal_hemorrhage1.11845756
64MP0005248_abnormal_Harderian_gland1.10339187
65MP0000427_abnormal_hair_cycle1.05367604
66MP0003828_pulmonary_edema1.03940625
67MP0002019_abnormal_tumor_incidence1.00445355
68MP0001845_abnormal_inflammatory_respons0.99691958
69MP0008995_early_reproductive_senescence0.98242015
70MP0002006_tumorigenesis0.97749477
71MP0005253_abnormal_eye_physiology0.97493181
72MP0003300_gastrointestinal_ulcer0.97250438
73MP0002277_abnormal_respiratory_mucosa0.96105442
74MP0001929_abnormal_gametogenesis0.95227957
75MP0004484_altered_response_of0.91926588
76MP0002638_abnormal_pupillary_reflex0.90500796
77MP0010307_abnormal_tumor_latency0.90362344
78MP0005310_abnormal_salivary_gland0.89938844
79MP0005464_abnormal_platelet_physiology0.87475470
80MP0002148_abnormal_hypersensitivity_rea0.87172373
81MP0006072_abnormal_retinal_apoptosis0.84707900
82MP0008874_decreased_physiological_sensi0.83544598
83MP0002127_abnormal_cardiovascular_syste0.80471920
84MP0005220_abnormal_exocrine_pancreas0.80309507
85MP0003122_maternal_imprinting0.80032448
86MP0006292_abnormal_olfactory_placode0.79927136
87MP0002693_abnormal_pancreas_physiology0.79077358
88MP0006035_abnormal_mitochondrial_morpho0.78433739
89MP0004264_abnormal_extraembryonic_tissu0.77155627
90MP0003195_calcinosis0.75733643
91MP0001119_abnormal_female_reproductive0.74718355
92MP0005645_abnormal_hypothalamus_physiol0.73672040
93MP0003693_abnormal_embryo_hatching0.72945212
94MP0003172_abnormal_lysosome_physiology0.71589884
95MP0010155_abnormal_intestine_physiology0.71137621
96MP0005395_other_phenotype0.67296544
97MP0008469_abnormal_protein_level0.66292562
98MP0000465_gastrointestinal_hemorrhage0.63381948
99MP0002210_abnormal_sex_determination0.60153474
100MP0004134_abnormal_chest_morphology0.59359205

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)4.59212035
2Decreased central vision (HP:0007663)3.92088951
3Colon cancer (HP:0003003)3.52845121
4Agnosia (HP:0010524)3.30895172
5Abnormal rod and cone electroretinograms (HP:0008323)3.19417542
6T lymphocytopenia (HP:0005403)3.17542923
7Disinhibition (HP:0000734)3.15783473
8Acanthocytosis (HP:0001927)3.15771629
9Tubulointerstitial nephritis (HP:0001970)2.93308753
10Recurrent bacterial skin infections (HP:0005406)2.85144174
11Combined immunodeficiency (HP:0005387)2.84699034
12Recurrent sinusitis (HP:0011108)2.84466749
13Severe combined immunodeficiency (HP:0004430)2.83800335
14Eczematoid dermatitis (HP:0000976)2.79655796
15Acute hepatic failure (HP:0006554)2.67199614
16Recurrent fungal infections (HP:0002841)2.65183639
17Long foot (HP:0001833)2.61336529
18Optic neuritis (HP:0100653)2.61038235
19Retrobulbar optic neuritis (HP:0100654)2.61038235
20Abnormality of T cell number (HP:0011839)2.59833330
21Medulloblastoma (HP:0002885)2.59200234
22Beaking of vertebral bodies (HP:0004568)2.58562618
23Recurrent abscess formation (HP:0002722)2.57588125
24Lymphopenia (HP:0001888)2.56821166
25Vasculitis (HP:0002633)2.56216916
26Elevated erythrocyte sedimentation rate (HP:0003565)2.54815740
27Medial flaring of the eyebrow (HP:0010747)2.54299360
28Pendular nystagmus (HP:0012043)2.53156456
29Prolonged bleeding time (HP:0003010)2.52994023
30Renal cortical cysts (HP:0000803)2.50238114
31Stomatitis (HP:0010280)2.48496055
32Congenital primary aphakia (HP:0007707)2.47304544
33Volvulus (HP:0002580)2.44925767
34Biliary tract neoplasm (HP:0100574)2.41856202
35Thyroiditis (HP:0100646)2.41340129
36Gaze-evoked nystagmus (HP:0000640)2.39768623
37Gastrointestinal infarctions (HP:0005244)2.37352865
38Basal cell carcinoma (HP:0002671)2.37109490
39Gait imbalance (HP:0002141)2.33298799
40Abnormality of the anterior horn cell (HP:0006802)2.32314805
41Degeneration of anterior horn cells (HP:0002398)2.32314805
42Poor coordination (HP:0002370)2.30497310
43Ependymoma (HP:0002888)2.26417201
44Orchitis (HP:0100796)2.26121532
45Encephalitis (HP:0002383)2.25394777
46Nephrogenic diabetes insipidus (HP:0009806)2.25116716
47Memory impairment (HP:0002354)2.24359667
48Agitation (HP:0000713)2.19320589
49Dyskinesia (HP:0100660)2.19280160
50IgM deficiency (HP:0002850)2.18258453
51Atrophy/Degeneration involving motor neurons (HP:0007373)2.17443953
52IgG deficiency (HP:0004315)2.13600624
53Myositis (HP:0100614)2.13558213
54Rhabdomyosarcoma (HP:0002859)2.12745820
55Abnormality of cells of the lymphoid lineage (HP:0012140)2.11257109
56Mediastinal lymphadenopathy (HP:0100721)2.08462881
57Gastrointestinal stroma tumor (HP:0100723)2.07829807
58Meningitis (HP:0001287)2.07775247
59Macroorchidism (HP:0000053)2.05671131
60Personality changes (HP:0000751)2.04279883
61Keratoconjunctivitis sicca (HP:0001097)2.00424377
62Amyotrophic lateral sclerosis (HP:0007354)1.99298494
63Truncal obesity (HP:0001956)1.98590429
64Lymphoma (HP:0002665)1.98303348
65Inappropriate behavior (HP:0000719)1.95213031
66Verrucae (HP:0200043)1.93310970
67Papilloma (HP:0012740)1.93310970
68Abnormality of T cells (HP:0002843)1.92242953
69Amaurosis fugax (HP:0100576)1.88823376
70Attenuation of retinal blood vessels (HP:0007843)1.88202540
71Thickened calvaria (HP:0002684)1.87337053
72Resting tremor (HP:0002322)1.86837323
73Recurrent bronchitis (HP:0002837)1.86101263
74Recurrent viral infections (HP:0004429)1.83725459
75Leukocytosis (HP:0001974)1.80780935
76Self-mutilation (HP:0000742)1.80173709
77Panhypogammaglobulinemia (HP:0003139)1.78701461
78Keratoconjunctivitis (HP:0001096)1.78230006
79Pancreatic fibrosis (HP:0100732)1.78193419
80Neoplasm of the adrenal cortex (HP:0100641)1.78171643
81Papillary thyroid carcinoma (HP:0002895)1.77664433
82Hypothermia (HP:0002045)1.76810465
83Nephroblastoma (Wilms tumor) (HP:0002667)1.76571010
84Leukopenia (HP:0001882)1.76384976
85Abnormality of macrophages (HP:0004311)1.75644122
86Urethral obstruction (HP:0000796)1.75290289
87Osteomyelitis (HP:0002754)1.73857390
88Agammaglobulinemia (HP:0004432)1.72649659
89Abnormality of chromosome segregation (HP:0002916)1.71079794
90Absent/shortened dynein arms (HP:0200106)1.70749032
91Dynein arm defect of respiratory motile cilia (HP:0012255)1.70749032
92Abnormality of the lumbar spine (HP:0100712)1.70628010
93Spontaneous hematomas (HP:0007420)1.70219091
94Genital tract atresia (HP:0001827)1.68677911
95Facial hemangioma (HP:0000329)1.67958465
96Abnormal delayed hypersensitivity skin test (HP:0002963)1.67614831
97Embryonal renal neoplasm (HP:0011794)1.67444935
98Broad foot (HP:0001769)1.66714396
99Neonatal hypoglycemia (HP:0001998)1.66538017
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.66535567

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR24.06879771
2RIPK43.50381268
3MAP3K43.47990355
4MAP4K13.03735090
5STK42.94137446
6EPHA32.92979449
7MAP2K72.81582355
8WNK32.71441536
9MAP4K22.46413423
10ERBB32.44158027
11MAP2K42.22862032
12FES2.10321791
13FRK2.04305677
14BUB11.82306245
15BRD41.75439317
16FGFR31.74895875
17TYK21.70667252
18MST41.70570833
19IRAK41.64834877
20MAP3K141.60818955
21BLK1.53215259
22STK31.42542666
23TNK21.39242712
24PRPF4B1.38370827
25BTK1.37776582
26DYRK31.34203102
27TXK1.30952103
28SIK31.26048603
29UHMK11.24062443
30MAP3K51.22046499
31YES11.16041179
32MAP2K31.15784184
33SYK1.12937367
34JAK11.12449786
35CSK1.10332658
36CAMKK21.08170709
37NLK1.07212421
38IKBKE0.98682234
39IRAK10.98434635
40TTK0.97432909
41HCK0.95781019
42PAK30.93748826
43STK100.91996345
44EIF2AK30.90382592
45FGFR20.90251083
46CSF1R0.89169135
47TRIM280.88715155
48MAP3K60.87580314
49TAOK30.87272548
50LYN0.86323817
51MARK20.85460589
52CDK90.85195322
53TEC0.83753789
54CDK60.83286590
55NEK90.82988516
56JAK20.82915047
57GRK60.81632915
58MARK30.81395323
59FGR0.78587347
60NUAK10.77121072
61PIK3CG0.77030493
62CDK120.75274716
63MAP3K100.75083470
64EPHB10.70995289
65DYRK1A0.66987627
66STK110.66958697
67LCK0.65177187
68STK240.63466708
69NEK60.60737811
70BRSK20.60063873
71FGFR40.58441569
72RPS6KA40.57702139
73ITK0.57392712
74TRPM70.55969518
75CHEK10.54755666
76PLK40.54103422
77TBK10.53878125
78ZAP700.49932403
79MKNK10.47993760
80ATR0.47912590
81TAOK10.44618529
82PIM10.43462202
83DAPK20.40732561
84MKNK20.40014780
85STK380.38890571
86RET0.38680142
87PRKCQ0.38252838
88BCR0.37187723
89PRKACB0.33121484
90MAP3K10.32907519
91PLK30.32089963
92MAPK90.31623684
93PRKG10.31206954
94PRKAA10.30892563
95SIK20.30802599
96PLK10.30675553
97HIPK20.29523799
98JAK30.28652366
99CDK20.27042826
100FER0.26662190

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.33978369
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.28429110
3Non-homologous end-joining_Homo sapiens_hsa034502.29474266
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.04725544
5B cell receptor signaling pathway_Homo sapiens_hsa046621.98609674
6RNA degradation_Homo sapiens_hsa030181.92015611
7Osteoclast differentiation_Homo sapiens_hsa043801.88903352
8Regulation of autophagy_Homo sapiens_hsa041401.87686120
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85390405
10Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.82926481
11Inositol phosphate metabolism_Homo sapiens_hsa005621.77854391
12Herpes simplex infection_Homo sapiens_hsa051681.69873011
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.68095573
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65489823
15Collecting duct acid secretion_Homo sapiens_hsa049661.59192665
16Measles_Homo sapiens_hsa051621.58451427
17Phosphatidylinositol signaling system_Homo sapiens_hsa040701.57975374
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54782857
19T cell receptor signaling pathway_Homo sapiens_hsa046601.49292433
20Spliceosome_Homo sapiens_hsa030401.46322264
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43991368
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42206837
23Leishmaniasis_Homo sapiens_hsa051401.42078168
24Antigen processing and presentation_Homo sapiens_hsa046121.41071722
25FoxO signaling pathway_Homo sapiens_hsa040681.39134147
26Basal transcription factors_Homo sapiens_hsa030221.34112367
27mRNA surveillance pathway_Homo sapiens_hsa030151.31597419
28Tuberculosis_Homo sapiens_hsa051521.31092142
29Shigellosis_Homo sapiens_hsa051311.29620040
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.29503896
31Colorectal cancer_Homo sapiens_hsa052101.26298813
32Chemokine signaling pathway_Homo sapiens_hsa040621.24601301
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24023505
34Hepatitis B_Homo sapiens_hsa051611.23741687
35Graft-versus-host disease_Homo sapiens_hsa053321.21621309
36Type I diabetes mellitus_Homo sapiens_hsa049401.20959831
37Sphingolipid signaling pathway_Homo sapiens_hsa040711.19735689
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17854542
39RNA transport_Homo sapiens_hsa030131.14210896
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12473864
41Prolactin signaling pathway_Homo sapiens_hsa049171.11035912
42Acute myeloid leukemia_Homo sapiens_hsa052211.11014930
43mTOR signaling pathway_Homo sapiens_hsa041501.10513789
44Legionellosis_Homo sapiens_hsa051341.09864421
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07700792
46Fanconi anemia pathway_Homo sapiens_hsa034601.05206627
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04635340
48Protein export_Homo sapiens_hsa030601.02442535
49Non-small cell lung cancer_Homo sapiens_hsa052231.01102087
50Hematopoietic cell lineage_Homo sapiens_hsa046401.00885478
51Epstein-Barr virus infection_Homo sapiens_hsa051690.99318677
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99197158
53Salmonella infection_Homo sapiens_hsa051320.97983606
54Endometrial cancer_Homo sapiens_hsa052130.97464285
55Butanoate metabolism_Homo sapiens_hsa006500.96327654
56Influenza A_Homo sapiens_hsa051640.95875730
57Cell cycle_Homo sapiens_hsa041100.93642075
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93114359
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91675493
60Mismatch repair_Homo sapiens_hsa034300.91489055
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.91199747
62Phagosome_Homo sapiens_hsa041450.86345269
63Nicotine addiction_Homo sapiens_hsa050330.85115188
64Hepatitis C_Homo sapiens_hsa051600.84574860
65Viral carcinogenesis_Homo sapiens_hsa052030.83853670
66Allograft rejection_Homo sapiens_hsa053300.83142672
67TNF signaling pathway_Homo sapiens_hsa046680.78918428
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78900775
69Autoimmune thyroid disease_Homo sapiens_hsa053200.76778973
70Homologous recombination_Homo sapiens_hsa034400.76225998
71Oocyte meiosis_Homo sapiens_hsa041140.73925521
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72218607
73Morphine addiction_Homo sapiens_hsa050320.70305843
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69881351
75Selenocompound metabolism_Homo sapiens_hsa004500.69568589
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68592356
77GABAergic synapse_Homo sapiens_hsa047270.66168053
78Apoptosis_Homo sapiens_hsa042100.65400586
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60898541
80Staphylococcus aureus infection_Homo sapiens_hsa051500.60868353
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60638675
82Pancreatic cancer_Homo sapiens_hsa052120.60527938
83Dopaminergic synapse_Homo sapiens_hsa047280.59367818
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59007910
85Synaptic vesicle cycle_Homo sapiens_hsa047210.57955390
86Circadian rhythm_Homo sapiens_hsa047100.56958015
87Dorso-ventral axis formation_Homo sapiens_hsa043200.54063715
88Toxoplasmosis_Homo sapiens_hsa051450.54001250
89Type II diabetes mellitus_Homo sapiens_hsa049300.53915739
90Choline metabolism in cancer_Homo sapiens_hsa052310.52755909
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.52395735
92p53 signaling pathway_Homo sapiens_hsa041150.52153531
93Endocytosis_Homo sapiens_hsa041440.50824502
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.50813905
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50450974
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49883003
97Rheumatoid arthritis_Homo sapiens_hsa053230.48755828
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.47436356
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45877423
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44333023

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