ZNF184

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is predicted to be a Kruppel C2H2-type zinc-finger protein family member. Sequence analysis predicts that the protein contains two Kruppel associated box (KRAB) boxes in the N-terminus and highly conserved zinc finger motifs at the C-terminus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neural tube formation (GO:0001841)4.32707215
2DNA double-strand break processing (GO:0000729)4.32235551
3microtubule depolymerization (GO:0007019)4.31100290
4regulation of DNA endoreduplication (GO:0032875)4.27819945
5centriole replication (GO:0007099)4.23527430
6negative regulation of DNA-dependent DNA replication (GO:2000104)3.95265323
7metaphase plate congression (GO:0051310)3.93133351
8nuclear pore complex assembly (GO:0051292)3.85534386
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.85186902
10regulation of centriole replication (GO:0046599)3.76019060
11sister chromatid cohesion (GO:0007062)3.69565040
12somatic hypermutation of immunoglobulin genes (GO:0016446)3.62916372
13somatic diversification of immune receptors via somatic mutation (GO:0002566)3.62916372
14replication fork processing (GO:0031297)3.58613446
15sister chromatid segregation (GO:0000819)3.55787335
16kinetochore organization (GO:0051383)3.53631029
17mitotic spindle checkpoint (GO:0071174)3.49753211
18microtubule polymerization or depolymerization (GO:0031109)3.48510059
19mitotic sister chromatid cohesion (GO:0007064)3.47952897
20spindle checkpoint (GO:0031577)3.42346296
21nuclear pore organization (GO:0006999)3.40979723
22non-recombinational repair (GO:0000726)3.40541939
23double-strand break repair via nonhomologous end joining (GO:0006303)3.40541939
24negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.38926046
25negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.38926046
26negative regulation of mitotic sister chromatid segregation (GO:0033048)3.38926046
27negative regulation of mitotic sister chromatid separation (GO:2000816)3.38926046
28negative regulation of sister chromatid segregation (GO:0033046)3.38926046
29kinetochore assembly (GO:0051382)3.36649531
30negative regulation of chromosome segregation (GO:0051985)3.35215957
31regulation of mitotic sister chromatid separation (GO:0010965)3.30710782
32regulation of mitotic sister chromatid segregation (GO:0033047)3.30710782
33regulation of sister chromatid segregation (GO:0033045)3.30710782
34mitotic spindle assembly checkpoint (GO:0007094)3.28177023
35regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.27429424
36regulation of mitotic metaphase/anaphase transition (GO:0030071)3.27429424
37spindle assembly checkpoint (GO:0071173)3.24333090
38regulation of chromosome segregation (GO:0051983)3.23861943
39maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.22968624
40chromatin remodeling at centromere (GO:0031055)3.22443793
41CENP-A containing nucleosome assembly (GO:0034080)3.17716223
42establishment of chromosome localization (GO:0051303)3.16185521
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.10654729
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.10654729
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.10654729
46mitotic metaphase plate congression (GO:0007080)3.09413963
47mitotic G2/M transition checkpoint (GO:0044818)3.04540760
48protein localization to chromosome (GO:0034502)3.03576469
49nucleotide-excision repair, DNA gap filling (GO:0006297)3.01475354
50mitotic sister chromatid segregation (GO:0000070)3.01161603
51meiotic chromosome segregation (GO:0045132)3.00198259
52negative regulation of DNA recombination (GO:0045910)2.99583879
53protein localization to kinetochore (GO:0034501)2.98587075
54regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98218641
55regulation of mitotic spindle checkpoint (GO:1903504)2.98218641
56regulation of sister chromatid cohesion (GO:0007063)2.98068021
57spermatid nucleus differentiation (GO:0007289)2.94462032
58protein-cofactor linkage (GO:0018065)2.94246358
59mitotic G2 DNA damage checkpoint (GO:0007095)2.93516722
60nucleobase biosynthetic process (GO:0046112)2.93432003
61positive regulation of chromosome segregation (GO:0051984)2.92658088
62pore complex assembly (GO:0046931)2.89926750
63histone exchange (GO:0043486)2.89486919
64presynaptic membrane assembly (GO:0097105)2.89469417
65microtubule anchoring (GO:0034453)2.89251330
66retinal cone cell development (GO:0046549)2.86481098
67postreplication repair (GO:0006301)2.85737629
68pyrimidine dimer repair (GO:0006290)2.85479451
69V(D)J recombination (GO:0033151)2.83813769
70mitotic recombination (GO:0006312)2.80522987
71histone H2A acetylation (GO:0043968)2.78011503
72DNA topological change (GO:0006265)2.76911616
73recombinational repair (GO:0000725)2.75692752
74double-strand break repair via homologous recombination (GO:0000724)2.75376413
75translesion synthesis (GO:0019985)2.74418587
76mitotic nuclear envelope disassembly (GO:0007077)2.73398288
77resolution of meiotic recombination intermediates (GO:0000712)2.73186454
78mismatch repair (GO:0006298)2.72785233
79centriole assembly (GO:0098534)2.72779305
80RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72698490
81DNA integration (GO:0015074)2.72078140
82DNA unwinding involved in DNA replication (GO:0006268)2.72053983
83protein localization to chromosome, centromeric region (GO:0071459)2.72011143
84synapsis (GO:0007129)2.70418668
85protein K11-linked deubiquitination (GO:0035871)2.69429706
86positive regulation of mRNA 3-end processing (GO:0031442)2.69067460
87intraciliary transport (GO:0042073)2.67530163
88cullin deneddylation (GO:0010388)2.66789860
89DNA ligation (GO:0006266)2.66689102
90regulation of histone H3-K9 methylation (GO:0051570)2.66214535
91DNA strand elongation involved in DNA replication (GO:0006271)2.65583730
92positive regulation of mRNA processing (GO:0050685)2.62881232
93acrosome reaction (GO:0007340)2.60613328
94histone mRNA metabolic process (GO:0008334)2.60336965
95regulation of meiosis I (GO:0060631)2.60168410
96DNA replication-independent nucleosome assembly (GO:0006336)2.60050828
97DNA replication-independent nucleosome organization (GO:0034724)2.60050828
98regulation of NFAT protein import into nucleus (GO:0051532)2.59973823
99protein localization to cilium (GO:0061512)2.57826610
100negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57594055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.56828165
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.49424015
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24924984
4IGF1R_20145208_ChIP-Seq_DFB_Human2.90442687
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.88146488
6* ZNF274_21170338_ChIP-Seq_K562_Hela2.74979440
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69446281
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57917783
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.51308426
10EWS_26573619_Chip-Seq_HEK293_Human2.49702926
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.42265308
12GBX2_23144817_ChIP-Seq_PC3_Human2.40302029
13FUS_26573619_Chip-Seq_HEK293_Human2.38131705
14TAF15_26573619_Chip-Seq_HEK293_Human2.32352038
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29058375
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28265906
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17482315
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.07335861
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05452403
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04728131
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.01038744
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00326191
23* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99299176
24* ELK1_19687146_ChIP-ChIP_HELA_Human1.97204700
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85702973
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82230075
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.79639419
28P300_19829295_ChIP-Seq_ESCs_Human1.78466795
29VDR_22108803_ChIP-Seq_LS180_Human1.77155464
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71201149
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.69257627
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.64693130
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59541082
34IRF1_19129219_ChIP-ChIP_H3396_Human1.57658680
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56918512
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55684277
37* VDR_23849224_ChIP-Seq_CD4+_Human1.50165454
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49511312
39ER_23166858_ChIP-Seq_MCF-7_Human1.47237664
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46542764
41EZH2_22144423_ChIP-Seq_EOC_Human1.41798618
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41401462
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39178668
44FOXP3_21729870_ChIP-Seq_TREG_Human1.38576739
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38543364
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.37085948
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35215589
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.32919020
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32735408
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31857031
51* E2F1_21310950_ChIP-Seq_MCF-7_Human1.30146920
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29871012
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29532183
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28886195
55CBP_20019798_ChIP-Seq_JUKART_Human1.28886195
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27689004
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27608886
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.26665815
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26466594
60STAT3_23295773_ChIP-Seq_U87_Human1.25761695
61* MYC_18940864_ChIP-ChIP_HL60_Human1.25610571
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.24984553
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22742271
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22630793
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21709634
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.21286578
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21005511
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20690118
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18584747
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16701292
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15521257
72AR_21572438_ChIP-Seq_LNCaP_Human1.15416814
73RNF2_27304074_Chip-Seq_NSC_Mouse1.14816350
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14324306
75TCF4_23295773_ChIP-Seq_U87_Human1.13623149
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08779114
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08701603
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.07460037
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.07336371
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06700735
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.06618012
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05769793
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05262651
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05185978
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04865126
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03391222
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.02995569
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02960531
89* RUNX2_22187159_ChIP-Seq_PCA_Human1.02389401
90P53_22387025_ChIP-Seq_ESCs_Mouse1.02108177
91AR_21909140_ChIP-Seq_LNCAP_Human1.00957864
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99997930
93E2F1_18555785_Chip-Seq_ESCs_Mouse0.99850116
94* SOX2_16153702_ChIP-ChIP_HESCs_Human0.99442640
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99025702
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99025702
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98465061
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.97024912
99AR_25329375_ChIP-Seq_VCAP_Human0.96962784
100TP53_22573176_ChIP-Seq_HFKS_Human0.94919551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.87729124
2MP0010094_abnormal_chromosome_stability3.84722005
3MP0008058_abnormal_DNA_repair3.49688344
4MP0002102_abnormal_ear_morphology3.13351330
5MP0003890_abnormal_embryonic-extraembry2.51294922
6MP0009697_abnormal_copulation2.45325027
7MP0003718_maternal_effect2.41531907
8MP0000569_abnormal_digit_pigmentation2.31719413
9MP0003077_abnormal_cell_cycle2.30309185
10MP0008877_abnormal_DNA_methylation2.27090801
11MP0003880_abnormal_central_pattern2.26836331
12MP0001529_abnormal_vocalization2.24979142
13MP0002132_abnormal_respiratory_system2.12458716
14MP0003121_genomic_imprinting2.07977395
15MP0003111_abnormal_nucleus_morphology2.06643290
16MP0003693_abnormal_embryo_hatching1.92775528
17MP0002822_catalepsy1.91883051
18MP0000778_abnormal_nervous_system1.81487313
19MP0003136_yellow_coat_color1.78324168
20MP0004147_increased_porphyrin_level1.75874674
21MP0003787_abnormal_imprinting1.61785944
22MP0004957_abnormal_blastocyst_morpholog1.59099531
23MP0008995_early_reproductive_senescence1.56917888
24MP0000631_abnormal_neuroendocrine_gland1.53437919
25MP0002653_abnormal_ependyma_morphology1.53005276
26MP0006072_abnormal_retinal_apoptosis1.48898140
27MP0005253_abnormal_eye_physiology1.48094278
28MP0002009_preneoplasia1.45688214
29MP0008932_abnormal_embryonic_tissue1.44103748
30MP0002751_abnormal_autonomic_nervous1.32091756
31MP0001293_anophthalmia1.29245537
32MP0002837_dystrophic_cardiac_calcinosis1.29243083
33MP0001486_abnormal_startle_reflex1.29104498
34MP0003567_abnormal_fetal_cardiomyocyte1.28164554
35MP0001929_abnormal_gametogenesis1.28104380
36MP0003221_abnormal_cardiomyocyte_apopto1.25550733
37MP0005646_abnormal_pituitary_gland1.25389043
38MP0002095_abnormal_skin_pigmentation1.25124668
39MP0003937_abnormal_limbs/digits/tail_de1.23666517
40MP0002210_abnormal_sex_determination1.21648241
41MP0009046_muscle_twitch1.20812318
42MP0005645_abnormal_hypothalamus_physiol1.20228271
43MP0005171_absent_coat_pigmentation1.19621592
44MP0002234_abnormal_pharynx_morphology1.18133444
45MP0001984_abnormal_olfaction1.18059003
46MP0003119_abnormal_digestive_system1.17804302
47MP0006276_abnormal_autonomic_nervous1.16851107
48MP0003786_premature_aging1.15374119
49MP0005551_abnormal_eye_electrophysiolog1.13621701
50MP0001188_hyperpigmentation1.12071091
51MP0003698_abnormal_male_reproductive1.10737799
52MP0000372_irregular_coat_pigmentation1.09895148
53MP0000427_abnormal_hair_cycle1.09088354
54MP0003861_abnormal_nervous_system1.09086538
55MP0006292_abnormal_olfactory_placode1.07720758
56MP0002184_abnormal_innervation1.07131376
57MP0008789_abnormal_olfactory_epithelium1.06740839
58MP0004924_abnormal_behavior1.04466082
59MP0005386_behavior/neurological_phenoty1.04466082
60MP0000653_abnormal_sex_gland1.03846606
61MP0000516_abnormal_urinary_system1.03524200
62MP0005367_renal/urinary_system_phenotyp1.03524200
63MP0002638_abnormal_pupillary_reflex1.02444299
64MP0001145_abnormal_male_reproductive1.02435950
65MP0004811_abnormal_neuron_physiology0.99748708
66MP0005499_abnormal_olfactory_system0.99048541
67MP0005394_taste/olfaction_phenotype0.99048541
68MP0005395_other_phenotype0.98829167
69MP0010307_abnormal_tumor_latency0.98766446
70MP0005075_abnormal_melanosome_morpholog0.97072312
71MP0001697_abnormal_embryo_size0.96896174
72MP0005391_vision/eye_phenotype0.96422962
73MP0004270_analgesia0.96275927
74MP0000647_abnormal_sebaceous_gland0.95780242
75MP0001286_abnormal_eye_development0.95340922
76MP0002736_abnormal_nociception_after0.95126564
77MP0002928_abnormal_bile_duct0.94227586
78MP0008007_abnormal_cellular_replicative0.91964976
79MP0003935_abnormal_craniofacial_develop0.91557844
80MP0001672_abnormal_embryogenesis/_devel0.91410315
81MP0005380_embryogenesis_phenotype0.91410315
82MP0003635_abnormal_synaptic_transmissio0.89608311
83MP0002272_abnormal_nervous_system0.87013153
84MP0005410_abnormal_fertilization0.86635348
85MP0003385_abnormal_body_wall0.85643082
86MP0002233_abnormal_nose_morphology0.85194107
87MP0002084_abnormal_developmental_patter0.84985379
88MP0002396_abnormal_hematopoietic_system0.84154993
89MP0009745_abnormal_behavioral_response0.82744897
90MP0002152_abnormal_brain_morphology0.82199714
91MP0003755_abnormal_palate_morphology0.80699841
92MP0002085_abnormal_embryonic_tissue0.79834670
93MP0008770_decreased_survivor_rate0.79032923
94MP0000955_abnormal_spinal_cord0.77700210
95MP0000049_abnormal_middle_ear0.77125537
96MP0002063_abnormal_learning/memory/cond0.77090535
97MP0002572_abnormal_emotion/affect_behav0.76300887
98MP0002882_abnormal_neuron_morphology0.75102542
99MP0005084_abnormal_gallbladder_morpholo0.73969685
100MP0002088_abnormal_embryonic_growth/wei0.73348992

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.35184501
2Colon cancer (HP:0003003)3.97283399
3Tubulointerstitial nephritis (HP:0001970)3.74985126
4Chromsome breakage (HP:0040012)3.57113043
5Medulloblastoma (HP:0002885)3.55929349
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.36455759
7Abnormality of chromosome stability (HP:0003220)2.99098569
8Ependymoma (HP:0002888)2.97753570
9Astrocytoma (HP:0009592)2.91512579
10Abnormality of the astrocytes (HP:0100707)2.91512579
11Glioma (HP:0009733)2.86139093
12True hermaphroditism (HP:0010459)2.84516675
13Focal motor seizures (HP:0011153)2.82233973
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.77873193
15Abnormality of the labia minora (HP:0012880)2.76161775
16Nephroblastoma (Wilms tumor) (HP:0002667)2.64014869
17Amyotrophic lateral sclerosis (HP:0007354)2.62970422
18Pancreatic fibrosis (HP:0100732)2.51867166
19Pancreatic cysts (HP:0001737)2.51785791
20Birth length less than 3rd percentile (HP:0003561)2.51207556
21Embryonal renal neoplasm (HP:0011794)2.50101335
22B lymphocytopenia (HP:0010976)2.44504267
23Progressive inability to walk (HP:0002505)2.36312094
24Thyroiditis (HP:0100646)2.36209203
25Chronic hepatic failure (HP:0100626)2.35846065
26Atrophy/Degeneration involving motor neurons (HP:0007373)2.29479818
27Severe combined immunodeficiency (HP:0004430)2.27698920
28Meckel diverticulum (HP:0002245)2.24181713
29Sloping forehead (HP:0000340)2.23708107
30Medial flaring of the eyebrow (HP:0010747)2.21231730
31Intestinal atresia (HP:0011100)2.20576475
32Central scotoma (HP:0000603)2.19963483
33Congenital primary aphakia (HP:0007707)2.19277646
34Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19166134
35Degeneration of the lateral corticospinal tracts (HP:0002314)2.19166134
36Gait imbalance (HP:0002141)2.15080096
37Abnormality of the ileum (HP:0001549)2.13272200
38Cortical dysplasia (HP:0002539)2.12983187
39Gaze-evoked nystagmus (HP:0000640)2.12818979
40Neoplasm of the oral cavity (HP:0100649)2.12069085
41Nephronophthisis (HP:0000090)2.11673321
42Combined immunodeficiency (HP:0005387)2.11545169
43Rhabdomyosarcoma (HP:0002859)2.10851181
44Abnormality of midbrain morphology (HP:0002418)2.09805178
45Molar tooth sign on MRI (HP:0002419)2.09805178
46Abnormality of the corticospinal tract (HP:0002492)2.09460203
47Drooling (HP:0002307)2.09326163
48Small hand (HP:0200055)2.09252319
49Lissencephaly (HP:0001339)2.08467812
50Nephrogenic diabetes insipidus (HP:0009806)2.08193721
51Abnormality of macular pigmentation (HP:0008002)2.08040476
52Abnormality of the preputium (HP:0100587)2.07294937
53Abnormal lung lobation (HP:0002101)2.01729643
54Duodenal stenosis (HP:0100867)2.00447579
55Small intestinal stenosis (HP:0012848)2.00447579
56Febrile seizures (HP:0002373)2.00053711
57Hypsarrhythmia (HP:0002521)1.99568099
58Abnormality of B cell number (HP:0010975)1.98843820
59Tubulointerstitial abnormality (HP:0001969)1.98704782
60Urinary urgency (HP:0000012)1.98187252
61Thyroid carcinoma (HP:0002890)1.96991887
62Papillary thyroid carcinoma (HP:0002895)1.96789808
63Genital tract atresia (HP:0001827)1.93798391
64Long clavicles (HP:0000890)1.92535941
65Abnormality of the renal medulla (HP:0100957)1.91871760
66Inability to walk (HP:0002540)1.91835057
67Fair hair (HP:0002286)1.91057868
68Renal cortical cysts (HP:0000803)1.88370959
69Excessive salivation (HP:0003781)1.88367928
70Neoplasm of striated muscle (HP:0009728)1.88082010
71Methylmalonic acidemia (HP:0002912)1.88002487
72Abnormality of the duodenum (HP:0002246)1.87484205
73Gonadotropin excess (HP:0000837)1.86523874
74Aplasia/Hypoplasia of the sternum (HP:0006714)1.83884176
75Postaxial foot polydactyly (HP:0001830)1.82970411
76Abnormality of the anterior horn cell (HP:0006802)1.82256902
77Degeneration of anterior horn cells (HP:0002398)1.82256902
78Neoplasm of the adrenal cortex (HP:0100641)1.81619513
79EEG with generalized epileptiform discharges (HP:0011198)1.80747395
80Increased nuchal translucency (HP:0010880)1.79807467
81Neoplasm of the colon (HP:0100273)1.79805341
82Vaginal atresia (HP:0000148)1.78702432
83Broad-based gait (HP:0002136)1.76637734
84Astigmatism (HP:0000483)1.76571022
85Embryonal neoplasm (HP:0002898)1.75096028
86Retinal dysplasia (HP:0007973)1.75008239
87Absent eyebrow (HP:0002223)1.74119806
88Myelodysplasia (HP:0002863)1.72384199
89Prominent nasal bridge (HP:0000426)1.72346810
90Scotoma (HP:0000575)1.71643210
91Aplasia/Hypoplasia of the tibia (HP:0005772)1.71458220
92Agnosia (HP:0010524)1.71292006
93Hypoproteinemia (HP:0003075)1.70704966
94Epileptiform EEG discharges (HP:0011182)1.70541679
95Abnormality of the carotid arteries (HP:0005344)1.70343575
96Hypoplasia of the thymus (HP:0000778)1.67871193
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.67554618
98Preaxial hand polydactyly (HP:0001177)1.65106005
99Overlapping toe (HP:0001845)1.64576625
100Abnormal hair whorl (HP:0010721)1.63252871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.44601964
2MAP3K43.21272442
3PLK42.84213422
4WNK32.81295242
5LATS12.64095313
6SRPK12.58612551
7BUB12.40961437
8WEE12.37390275
9NUAK12.35349651
10BCR2.16538185
11TRIM282.16323221
12EPHA42.15405170
13MAP2K72.09692359
14BRSK22.06025386
15FRK2.03478483
16STK38L1.91911552
17MKNK21.86364898
18BRD41.84357821
19CDC71.80107002
20TTK1.76796243
21ERBB31.72125494
22MKNK11.71156107
23VRK11.67492985
24TAF11.65477312
25PLK21.62489362
26EIF2AK31.59737504
27MAPK131.59373336
28DYRK31.58266270
29ZAK1.55322296
30PLK31.52953223
31PNCK1.47450731
32NEK11.47172321
33CASK1.44463062
34TSSK61.41521322
35CCNB11.40499423
36TNIK1.33375046
37PLK11.30503560
38MARK11.17751712
39MAP3K61.16730438
40CHEK21.15737054
41BMPR1B1.15361556
42ATR1.09711431
43CSNK1A1L1.09675242
44MINK11.00695447
45CSNK1G21.00231520
46MST40.98973768
47EIF2AK10.98293524
48CSNK1G10.97878005
49RPS6KA40.92910898
50ITK0.86980307
51INSRR0.85834912
52ATM0.85156872
53CSNK1G30.84658262
54PBK0.84042604
55MAP2K40.82993539
56STK390.77821991
57CDK30.76666144
58NEK20.76280585
59AURKB0.71440430
60EIF2AK20.69187037
61DYRK20.67980755
62TAOK30.67708339
63PTK2B0.65070930
64CDK190.64675499
65UHMK10.64296732
66CLK10.62090546
67STK30.61954832
68BRSK10.58390872
69AKT30.56616125
70VRK20.54585998
71GRK10.52267506
72CHEK10.47972441
73YES10.45649772
74CDK70.45647906
75RPS6KB10.44624943
76ACVR1B0.43822183
77PRKCE0.43156627
78PINK10.41534843
79SGK20.40750709
80DYRK1A0.40439122
81ADRBK20.39474168
82NLK0.38630052
83PKN10.38613330
84SIK20.38525267
85CDK10.38210969
86CDK20.36570554
87CSNK1D0.34806868
88CDK80.34459844
89CSNK1E0.32274034
90RPS6KA50.31297205
91PIM10.30039885
92TGFBR10.29929498
93CAMKK20.29789125
94PRKDC0.28196146
95PRKACB0.28065667
96CSNK1A10.27729656
97PRKCG0.27297052
98AURKA0.26035686
99STK380.25450010
100TEC0.25299113

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.82610087
2Mismatch repair_Homo sapiens_hsa034303.53868835
3Basal transcription factors_Homo sapiens_hsa030223.45423141
4Fanconi anemia pathway_Homo sapiens_hsa034603.35294564
5DNA replication_Homo sapiens_hsa030303.05426403
6Homologous recombination_Homo sapiens_hsa034403.02428766
7Cell cycle_Homo sapiens_hsa041102.84206473
8Base excision repair_Homo sapiens_hsa034102.71112556
9RNA transport_Homo sapiens_hsa030132.53009678
10RNA degradation_Homo sapiens_hsa030182.46593133
11Protein export_Homo sapiens_hsa030602.44527655
12Spliceosome_Homo sapiens_hsa030402.36738580
13Phototransduction_Homo sapiens_hsa047442.10166818
14Nucleotide excision repair_Homo sapiens_hsa034202.04921812
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02481453
16Nicotine addiction_Homo sapiens_hsa050331.91752227
17Oocyte meiosis_Homo sapiens_hsa041141.88272904
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85895501
19mRNA surveillance pathway_Homo sapiens_hsa030151.78081058
20Propanoate metabolism_Homo sapiens_hsa006401.76564707
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72251662
22Taste transduction_Homo sapiens_hsa047421.57250154
23RNA polymerase_Homo sapiens_hsa030201.55687782
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.55213139
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52491628
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49174392
27Steroid biosynthesis_Homo sapiens_hsa001001.43675529
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43053701
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29508221
30Colorectal cancer_Homo sapiens_hsa052101.28920062
31Olfactory transduction_Homo sapiens_hsa047401.14522119
32Alcoholism_Homo sapiens_hsa050341.13939023
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11826046
34p53 signaling pathway_Homo sapiens_hsa041151.04663886
35Pyrimidine metabolism_Homo sapiens_hsa002401.03494651
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99915326
37Purine metabolism_Homo sapiens_hsa002300.97734063
38GABAergic synapse_Homo sapiens_hsa047270.96087757
39Regulation of autophagy_Homo sapiens_hsa041400.93457959
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.92747893
41One carbon pool by folate_Homo sapiens_hsa006700.91608875
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91523802
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87670026
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86021244
45Butanoate metabolism_Homo sapiens_hsa006500.81724751
46Axon guidance_Homo sapiens_hsa043600.71241110
47Selenocompound metabolism_Homo sapiens_hsa004500.69070953
48Dopaminergic synapse_Homo sapiens_hsa047280.67402356
49Circadian rhythm_Homo sapiens_hsa047100.66467187
50Morphine addiction_Homo sapiens_hsa050320.66184491
51mTOR signaling pathway_Homo sapiens_hsa041500.65355055
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64704298
53Wnt signaling pathway_Homo sapiens_hsa043100.62054088
54TGF-beta signaling pathway_Homo sapiens_hsa043500.60204474
55Viral carcinogenesis_Homo sapiens_hsa052030.59434177
56Systemic lupus erythematosus_Homo sapiens_hsa053220.59393277
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56919774
58Dorso-ventral axis formation_Homo sapiens_hsa043200.52870509
59MicroRNAs in cancer_Homo sapiens_hsa052060.52546039
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.51999356
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49625506
62Glutamatergic synapse_Homo sapiens_hsa047240.47972444
63Amphetamine addiction_Homo sapiens_hsa050310.45555930
64Epstein-Barr virus infection_Homo sapiens_hsa051690.41117747
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39911154
66Ether lipid metabolism_Homo sapiens_hsa005650.34295572
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.33759249
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33663622
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33091608
70Huntingtons disease_Homo sapiens_hsa050160.32934617
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32428424
72Serotonergic synapse_Homo sapiens_hsa047260.31788678
73Proteasome_Homo sapiens_hsa030500.31671681
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31196036
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29344710
76Melanoma_Homo sapiens_hsa052180.29285616
77Gap junction_Homo sapiens_hsa045400.29123731
78Folate biosynthesis_Homo sapiens_hsa007900.28978974
79Hippo signaling pathway_Homo sapiens_hsa043900.28581058
80Circadian entrainment_Homo sapiens_hsa047130.25846446
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25643790
82ErbB signaling pathway_Homo sapiens_hsa040120.25167287
83N-Glycan biosynthesis_Homo sapiens_hsa005100.25013704
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.24989207
85Basal cell carcinoma_Homo sapiens_hsa052170.24787561
86FoxO signaling pathway_Homo sapiens_hsa040680.23353284
87Cocaine addiction_Homo sapiens_hsa050300.23213174
88Choline metabolism in cancer_Homo sapiens_hsa052310.23091740
89Long-term depression_Homo sapiens_hsa047300.22548561
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22069391
91Metabolic pathways_Homo sapiens_hsa011000.22033393
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21472883
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19819995
94Adherens junction_Homo sapiens_hsa045200.18952365
95Lysine degradation_Homo sapiens_hsa003100.16545226
96Endometrial cancer_Homo sapiens_hsa052130.15657126
97Herpes simplex infection_Homo sapiens_hsa051680.14898244
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14813483
99Cholinergic synapse_Homo sapiens_hsa047250.14504290
100Pyruvate metabolism_Homo sapiens_hsa006200.13728107

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