ZNF185

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.66570578
2hemidesmosome assembly (GO:0031581)5.67587224
3thrombin receptor signaling pathway (GO:0070493)5.37851692
4desmosome organization (GO:0002934)4.99708423
5establishment of skin barrier (GO:0061436)4.90310750
6regulation of platelet aggregation (GO:0090330)4.56495718
7lipoxygenase pathway (GO:0019372)4.50997132
8regulation of water loss via skin (GO:0033561)4.50044708
9keratinization (GO:0031424)4.46564439
10leukocyte migration involved in inflammatory response (GO:0002523)4.40114369
11neutrophil activation (GO:0042119)4.31357594
12G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.24585705
13platelet aggregation (GO:0070527)4.21109427
14negative regulation of homotypic cell-cell adhesion (GO:0034111)4.16391874
15angiogenesis involved in wound healing (GO:0060055)4.12692485
16positive regulation of mast cell activation (GO:0033005)4.06647103
17regulation of platelet activation (GO:0010543)4.04897119
18granulocyte activation (GO:0036230)3.97873067
19adenosine receptor signaling pathway (GO:0001973)3.88482258
20mesodermal cell differentiation (GO:0048333)3.84528901
21regulation of integrin activation (GO:0033623)3.80481612
22positive regulation of receptor recycling (GO:0001921)3.72173585
23cell-substrate junction assembly (GO:0007044)3.70780440
24hypotonic response (GO:0006971)3.60561232
25protein neddylation (GO:0045116)3.58688735
26regulation of integrin-mediated signaling pathway (GO:2001044)3.55738008
27G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.47799529
28negative regulation of platelet activation (GO:0010544)3.42321783
29negative regulation of interleukin-17 production (GO:0032700)3.41466205
30homotypic cell-cell adhesion (GO:0034109)3.27433032
31positive regulation of endothelial cell differentiation (GO:0045603)3.26969026
32keratinocyte differentiation (GO:0030216)3.26753773
33megakaryocyte development (GO:0035855)3.26599739
34positive regulation of Cdc42 GTPase activity (GO:0043089)3.25371600
35platelet degranulation (GO:0002576)3.21232101
36detection of other organism (GO:0098543)3.20090705
37positive regulation of Rho protein signal transduction (GO:0035025)3.18926486
38peptide cross-linking (GO:0018149)3.16942491
39regulation of mast cell degranulation (GO:0043304)3.14795606
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13779976
41bundle of His cell to Purkinje myocyte communication (GO:0086069)3.13611892
42detection of bacterium (GO:0016045)3.09515198
43regulation of leukocyte degranulation (GO:0043300)3.06812691
44protein localization to endosome (GO:0036010)3.06715626
45regulation of homotypic cell-cell adhesion (GO:0034110)3.00072310
46negative regulation of stress fiber assembly (GO:0051497)2.99355638
47positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.96224362
48positive regulation of macrophage differentiation (GO:0045651)2.94189850
49regulation of mast cell activation involved in immune response (GO:0033006)2.93668374
50regulation of mast cell activation (GO:0033003)2.93436561
51fatty acid elongation (GO:0030497)2.93035857
52platelet formation (GO:0030220)2.90734981
53purinergic nucleotide receptor signaling pathway (GO:0035590)2.90450292
54platelet activation (GO:0030168)2.89802129
55positive regulation of blood coagulation (GO:0030194)2.89346854
56positive regulation of hemostasis (GO:1900048)2.89346854
57regulation of myeloid leukocyte mediated immunity (GO:0002886)2.87908915
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84504066
59positive regulation by organism of defense response of other organism involved in symbiotic interact2.84504066
60modulation by symbiont of host immune response (GO:0052553)2.84504066
61positive regulation by symbiont of host defense response (GO:0052509)2.84504066
62modulation by symbiont of host defense response (GO:0052031)2.84504066
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84504066
64leukocyte degranulation (GO:0043299)2.82920868
65response to peptidoglycan (GO:0032494)2.81179024
66positive regulation of leukocyte degranulation (GO:0043302)2.78193491
67negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.78095424
68positive regulation of hair follicle development (GO:0051798)2.76827774
69positive regulation of hair cycle (GO:0042635)2.76827774
70purinergic receptor signaling pathway (GO:0035587)2.72793361
71negative regulation of protein localization to plasma membrane (GO:1903077)2.71635411
72myeloid cell activation involved in immune response (GO:0002275)2.71469216
73positive regulation of coagulation (GO:0050820)2.71019935
74hepatocyte apoptotic process (GO:0097284)2.69835826
75epithelial cell-cell adhesion (GO:0090136)2.69524301
76long-chain fatty acid biosynthetic process (GO:0042759)2.69400134
77negative regulation of erythrocyte differentiation (GO:0045647)2.69092343
78endothelium development (GO:0003158)2.68989176
79blood coagulation, intrinsic pathway (GO:0007597)2.65834800
80regulation of interleukin-17 production (GO:0032660)2.65764225
81negative regulation of neural precursor cell proliferation (GO:2000178)2.64138902
82regulation of T-helper 2 cell differentiation (GO:0045628)2.63393802
83phagocytosis, engulfment (GO:0006911)2.62698289
84peptide catabolic process (GO:0043171)2.62532771
85extracellular fibril organization (GO:0043206)2.61954261
86negative regulation of thymocyte apoptotic process (GO:0070244)2.59967075
87multicellular organismal water homeostasis (GO:0050891)2.59827435
88positive regulation of mast cell degranulation (GO:0043306)2.59197618
89positive regulation of mast cell activation involved in immune response (GO:0033008)2.59197618
90fibril organization (GO:0097435)2.59170702
91keratinocyte proliferation (GO:0043616)2.54920885
92positive regulation of cellular amide metabolic process (GO:0034250)2.54615598
93integrin-mediated signaling pathway (GO:0007229)2.52213845
94negative regulation of protein localization to cell surface (GO:2000009)2.49965588
95histamine transport (GO:0051608)2.49596940
96negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.49148717
97negative regulation of T-helper cell differentiation (GO:0045623)2.48623267
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.48623267
99regulation of early endosome to late endosome transport (GO:2000641)2.48473729
100epidermal cell differentiation (GO:0009913)2.46190375

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.01602556
2MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83441299
3SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.82470908
4MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58562896
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.55695343
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.55476869
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.47214844
8GATA2_21666600_ChIP-Seq_HMVEC_Human2.42553961
9SCL_19346495_ChIP-Seq_HPC-7_Human2.41188331
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40590992
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.36999294
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35619917
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26123606
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20131922
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.17133508
16SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.16228068
17SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.16228068
18SPI1_23127762_ChIP-Seq_K562_Human2.13113912
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.12075016
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11389886
21GATA1_19941826_ChIP-Seq_K562_Human2.09157518
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.08933514
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08159285
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.97634516
25GATA1_19941827_ChIP-Seq_MEL_Mouse1.95981904
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.92413690
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.89557311
28P63_26484246_Chip-Seq_KERATINOCYTES_Human1.89021124
29TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.87057149
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.84307528
31GATA2_19941826_ChIP-Seq_K562_Human1.83444239
32GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.81895367
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.78241162
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77630741
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76009984
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74222327
37SOX9_24532713_ChIP-Seq_HFSC_Mouse1.69537447
38GATA1_22383799_ChIP-Seq_G1ME_Mouse1.63626146
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60120861
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59473469
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55727151
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52776035
43* SOX2_20726797_ChIP-Seq_SW620_Human1.52554630
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49822191
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.49452714
46* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45437860
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44785036
48TCF7_22412390_ChIP-Seq_EML_Mouse1.43820806
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43320901
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40628028
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37958547
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37742752
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35956651
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34703971
55VDR_24763502_ChIP-Seq_THP-1_Human1.34590128
56JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34563924
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32347024
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27923709
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26845068
60RACK7_27058665_Chip-Seq_MCF-7_Human1.24314996
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22254577
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19529791
63ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19079591
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18419909
65JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18183621
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16883224
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14384686
68FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13997142
69ATF3_27146783_Chip-Seq_COLON_Human1.13690257
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.13001478
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12635816
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12589420
73SPI1_23547873_ChIP-Seq_NB4_Human1.12311649
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11601738
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08806337
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07961602
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07357455
78TP63_23658742_ChIP-Seq_EP156T_Human1.07189439
79GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05952886
80NCOR1_26117541_ChIP-Seq_K562_Human1.05388582
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.04896102
82UTX_26944678_Chip-Seq_JUKART_Human1.04399036
83MAF_26560356_Chip-Seq_TH1_Human1.04298079
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02619206
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02331203
86LXR_22292898_ChIP-Seq_THP-1_Human1.01245184
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00737948
88RUNX_20019798_ChIP-Seq_JUKART_Human0.99664574
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99649083
90TP63_22573176_ChIP-Seq_HFKS_Human0.99257298
91ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96464898
92P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95964451
93GATA4_25053715_ChIP-Seq_YYC3_Human0.95602332
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92899039
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92805208
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.91747754
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91099387
98PU_27001747_Chip-Seq_BMDM_Mouse0.90372067
99GATA6_25053715_ChIP-Seq_YYC3_Human0.89146220
100KDM2B_26808549_Chip-Seq_DND41_Human0.87827726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology5.91881618
2MP0003566_abnormal_cell_adhesion3.94085866
3MP0008004_abnormal_stomach_pH3.62467294
4MP0002796_impaired_skin_barrier3.62141745
5MP0000579_abnormal_nail_morphology3.31029506
6MP0003724_increased_susceptibility_to3.03948717
7MP0010234_abnormal_vibrissa_follicle3.00778074
8MP0000465_gastrointestinal_hemorrhage2.89436048
9MP0003453_abnormal_keratinocyte_physiol2.72088272
10MP0005501_abnormal_skin_physiology2.63800926
11MP0004947_skin_inflammation2.40024023
12MP0004510_myositis2.32774715
13MP0003303_peritoneal_inflammation2.30068927
14MP0005275_abnormal_skin_tensile2.20158779
15MP0003828_pulmonary_edema2.12412952
16MP0003436_decreased_susceptibility_to2.09671261
17MP0005409_darkened_coat_color2.05456546
18MP0001851_eye_inflammation1.94858902
19MP0010678_abnormal_skin_adnexa1.94490073
20MP0001216_abnormal_epidermal_layer1.93716860
21MP0005023_abnormal_wound_healing1.90365177
22MP0003191_abnormal_cellular_cholesterol1.88589554
23MP0000858_altered_metastatic_potential1.85953324
24MP0004381_abnormal_hair_follicle1.85312385
25MP0000383_abnormal_hair_follicle1.78139533
26MP0003705_abnormal_hypodermis_morpholog1.77302745
27MP0000467_abnormal_esophagus_morphology1.75384287
28MP0005083_abnormal_biliary_tract1.73037812
29MP0001835_abnormal_antigen_presentation1.71689646
30MP0002877_abnormal_melanocyte_morpholog1.67388690
31MP0005058_abnormal_lysosome_morphology1.65916817
32MP0008260_abnormal_autophagy1.64706184
33MP0003300_gastrointestinal_ulcer1.61889728
34MP0001849_ear_inflammation1.55135967
35MP0004264_abnormal_extraembryonic_tissu1.54597782
36MP0010352_gastrointestinal_tract_polyps1.54184160
37MP0002148_abnormal_hypersensitivity_rea1.48444907
38MP0001533_abnormal_skeleton_physiology1.46899753
39MP0000343_altered_response_to1.46031344
40MP0010771_integument_phenotype1.45390785
41MP0002060_abnormal_skin_morphology1.40385110
42MP0010155_abnormal_intestine_physiology1.38835270
43MP0002098_abnormal_vibrissa_morphology1.38022094
44MP0004272_abnormal_basement_membrane1.35540815
45MP0002419_abnormal_innate_immunity1.32119240
46MP0004084_abnormal_cardiac_muscle1.31869433
47MP0005000_abnormal_immune_tolerance1.27741819
48MP0003091_abnormal_cell_migration1.21774935
49MP0009053_abnormal_anal_canal1.20870942
50MP0003638_abnormal_response/metabolism_1.19256226
51MP0000377_abnormal_hair_follicle1.11606670
52MP0002452_abnormal_antigen_presenting1.10091903
53MP0005025_abnormal_response_to1.08690480
54MP0009931_abnormal_skin_appearance1.08094716
55MP0002723_abnormal_immune_serum1.05346341
56MP0003075_altered_response_to1.04154579
57MP0000249_abnormal_blood_vessel1.03797174
58MP0004883_abnormal_blood_vessel1.03625118
59MP0001879_abnormal_lymphatic_vessel1.00445078
60MP0001790_abnormal_immune_system0.99640456
61MP0005387_immune_system_phenotype0.99640456
62MP0000685_abnormal_immune_system0.98928783
63MP0002998_abnormal_bone_remodeling0.98575497
64MP0003941_abnormal_skin_development0.96700828
65MP0001819_abnormal_immune_cell0.96070613
66MP0002420_abnormal_adaptive_immunity0.96050046
67MP0000762_abnormal_tongue_morphology0.95356259
68MP0001800_abnormal_humoral_immune0.94312878
69MP0003448_altered_tumor_morphology0.93570835
70MP0005164_abnormal_response_to0.93282838
71MP0003806_abnormal_nucleotide_metabolis0.92742351
72MP0002398_abnormal_bone_marrow0.90828285
73MP0005165_increased_susceptibility_to0.87753057
74MP0006054_spinal_hemorrhage0.85698220
75MP0005397_hematopoietic_system_phenotyp0.82261841
76MP0001545_abnormal_hematopoietic_system0.82261841
77MP0002132_abnormal_respiratory_system0.81696404
78MP0001845_abnormal_inflammatory_respons0.81500838
79MP0009764_decreased_sensitivity_to0.81427887
80MP0009333_abnormal_splenocyte_physiolog0.80837437
81MP0005666_abnormal_adipose_tissue0.79438334
82MP0005167_abnormal_blood-brain_barrier0.79381851
83MP0001663_abnormal_digestive_system0.79202348
84MP0009763_increased_sensitivity_to0.78659712
85MP0001191_abnormal_skin_condition0.78515982
86MP0005671_abnormal_response_to0.76236721
87MP0003045_fibrosis0.76214887
88MP0005390_skeleton_phenotype0.74737812
89MP0000230_abnormal_systemic_arterial0.74116536
90MP0004130_abnormal_muscle_cell0.73501730
91MP0009785_altered_susceptibility_to0.73036555
92MP0010368_abnormal_lymphatic_system0.72945546
93MP0002429_abnormal_blood_cell0.72404887
94MP0004185_abnormal_adipocyte_glucose0.71735675
95MP0000490_abnormal_crypts_of0.70281904
96MP0006138_congestive_heart_failure0.69405571
97MP0000716_abnormal_immune_system0.68663728
98MP0003656_abnormal_erythrocyte_physiolo0.67157336
99MP0008874_decreased_physiological_sensi0.65227223
100MP0003763_abnormal_thymus_physiology0.62984697

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)7.79485305
2Menorrhagia (HP:0000132)7.43619188
3Increased mean platelet volume (HP:0011877)7.38833910
4Abnormal platelet volume (HP:0011876)7.12982208
5Petechiae (HP:0000967)6.56008948
6Purpura (HP:0000979)5.85916225
7Epistaxis (HP:0000421)5.46156565
8Abnormality of nail color (HP:0100643)4.96346924
9Gingival bleeding (HP:0000225)4.92810865
10Thick nail (HP:0001805)4.72599642
11Impaired platelet aggregation (HP:0003540)4.22516979
12Abnormal platelet function (HP:0011869)4.22516979
13Onycholysis (HP:0001806)4.20384864
14Plantar hyperkeratosis (HP:0007556)4.19620204
15Milia (HP:0001056)4.03022556
16Palmoplantar hyperkeratosis (HP:0000972)3.69470398
17Fragile nails (HP:0001808)3.67283848
18Alopecia of scalp (HP:0002293)3.59736130
19Spontaneous hematomas (HP:0007420)3.48542600
20Palmar hyperkeratosis (HP:0010765)3.42624080
21Increased IgE level (HP:0003212)3.29478311
22Nail dystrophy (HP:0008404)3.27257027
23Right ventricular cardiomyopathy (HP:0011663)3.22721502
24Abnormality of macrophages (HP:0004311)2.98313192
25Eczematoid dermatitis (HP:0000976)2.93617905
26Hyperlipoproteinemia (HP:0010980)2.88399973
27Bruising susceptibility (HP:0000978)2.85398006
28Abnormal blistering of the skin (HP:0008066)2.83944408
29Erythema (HP:0010783)2.73901690
30Oral leukoplakia (HP:0002745)2.73767211
31Atrophic scars (HP:0001075)2.67947836
32Recurrent bacterial skin infections (HP:0005406)2.67412201
33Ridged nail (HP:0001807)2.58638993
34Abnormality of the common coagulation pathway (HP:0010990)2.46387733
35Hypotrichosis (HP:0001006)2.40654392
36Congenital ichthyosiform erythroderma (HP:0007431)2.32666836
37Hepatosplenomegaly (HP:0001433)2.26951575
38Pustule (HP:0200039)2.26465064
39Distal lower limb amyotrophy (HP:0008944)2.25417165
40Corneal erosion (HP:0200020)2.21123082
41Ankyloglossia (HP:0010296)2.19115183
42Acanthocytosis (HP:0001927)2.18178038
43Pili torti (HP:0003777)2.15808490
44Recurrent abscess formation (HP:0002722)2.14655061
45Distal lower limb muscle weakness (HP:0009053)2.10862644
46Conjunctival telangiectasia (HP:0000524)2.05445749
47Increased density of long bones (HP:0006392)2.05279235
48Lip pit (HP:0100267)2.04193940
49Stomatitis (HP:0010280)2.02107807
50Urticaria (HP:0001025)2.01368632
51Dyschromatopsia (HP:0007641)2.00963094
52Abnormality of oral frenula (HP:0000190)2.00283819
53Poikilocytosis (HP:0004447)1.99765510
54Abnormality of the vasculature of the conjunctiva (HP:0008054)1.99156038
55Woolly hair (HP:0002224)1.96833273
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.95160533
57Erythroderma (HP:0001019)1.93595142
58Abnormal auditory evoked potentials (HP:0006958)1.92228793
59Paralysis (HP:0003470)1.89867685
60Aplasia cutis congenita (HP:0001057)1.85157776
61Hypoplasia of dental enamel (HP:0006297)1.84507316
62Abnormal pupillary function (HP:0007686)1.80039101
63Skin ulcer (HP:0200042)1.79161424
64Gangrene (HP:0100758)1.77129669
65Increased IgM level (HP:0003496)1.75861592
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74407976
67Abnormality of iron homeostasis (HP:0011031)1.74324764
68Interstitial pulmonary disease (HP:0006530)1.73227283
69Sparse scalp hair (HP:0002209)1.73014053
70Osteolytic defects of the hand bones (HP:0009699)1.71254961
71Osteolytic defects of the phalanges of the hand (HP:0009771)1.71254961
72Natal tooth (HP:0000695)1.70796568
73Arterial thrombosis (HP:0004420)1.70437555
74Dysostosis multiplex (HP:0000943)1.69034404
75Palmoplantar keratoderma (HP:0000982)1.68636887
76Abnormal hair laboratory examination (HP:0003328)1.68469037
77Ectropion (HP:0000656)1.68199995
78Selective tooth agenesis (HP:0001592)1.67906328
79Myocardial infarction (HP:0001658)1.67485895
80Sparse eyelashes (HP:0000653)1.64301345
81Curly hair (HP:0002212)1.61733441
82Increased cerebral lipofuscin (HP:0011813)1.60415353
83Episodic fever (HP:0001954)1.60115011
84Obstructive lung disease (HP:0006536)1.59772326
85Chronic obstructive pulmonary disease (HP:0006510)1.59772326
86Increased serum ferritin (HP:0003281)1.59657940
87Multifactorial inheritance (HP:0001426)1.59207545
88Joint swelling (HP:0001386)1.59020441
89Fragile skin (HP:0001030)1.57786446
90Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.56628824
91Joint hemorrhage (HP:0005261)1.56475921
92Hypergammaglobulinemia (HP:0010702)1.55027332
93Broad face (HP:0000283)1.55002699
94Amyloidosis (HP:0011034)1.54922698
95Keratoconjunctivitis sicca (HP:0001097)1.53126955
96Flat acetabular roof (HP:0003180)1.51732699
97Upper limb muscle weakness (HP:0003484)1.50320370
98Elevated erythrocyte sedimentation rate (HP:0003565)1.48636171
99Abnormality of the salivary glands (HP:0010286)1.47340973
100Myositis (HP:0100614)1.47151703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.38315203
2EPHA23.40921168
3BMX3.12963463
4MST42.88112107
5MST1R2.53804230
6MYLK2.22890873
7BMPR22.14779363
8MAP3K32.10212681
9ZAP702.09872950
10BTK2.09775755
11SIK31.93222553
12PTK2B1.90243333
13MAP2K31.87554550
14SIK11.82449007
15CSF1R1.82219897
16EPHB11.76942237
17IRAK31.72244599
18EIF2AK11.71494816
19FGR1.67168448
20MET1.66296620
21EPHB21.61353566
22STK241.58138717
23TEC1.55573718
24CSK1.48905944
25BLK1.41114849
26MAPKAPK31.39570026
27LMTK21.36914829
28GRK61.36606935
29ILK1.36473563
30SYK1.31801480
31PTK21.27860974
32MAP3K61.27454503
33HCK1.27145771
34STK31.25915431
35MAP3K21.16435728
36ARAF1.13093163
37IRAK41.11936830
38TAOK11.11208841
39FER1.09746009
40PIK3CG1.05530876
41PRPF4B1.02998880
42TRIB31.01950184
43ERN11.01412117
44RIPK11.00900304
45FES0.98528346
46CDK120.96744517
47TAOK20.95363410
48IRAK10.94828938
49GRK50.92291934
50MAP3K10.91941283
51RET0.90308579
52STK100.89490447
53MAP3K110.89271986
54PAK40.89250779
55JAK30.88788329
56PKN20.87232065
57IKBKB0.86789483
58TTN0.85078841
59TRPM70.83090651
60PDGFRB0.81865678
61PIM20.80454980
62TESK20.80135668
63LRRK20.79746176
64MATK0.79457777
65FLT30.78442157
66PDPK10.76823614
67TGFBR20.76165516
68MAP3K120.75877095
69PAK10.71770975
70IRAK20.70052371
71STK380.69269990
72TAOK30.66816673
73SMG10.66685222
74MARK30.63514181
75YES10.61437121
76ERBB20.61027485
77KSR20.60340592
78CDC42BPA0.59780033
79MAP3K50.59329608
80PDK10.58560351
81LYN0.55080344
82MAP4K10.53773784
83TNK20.53013698
84TGFBR10.51895198
85DMPK0.51247083
86MAP3K90.51080011
87MAP2K10.49261243
88PTK60.48173479
89MAPKAPK20.47442774
90HIPK20.46549915
91TBK10.46486413
92ITK0.45617591
93TESK10.45493077
94MARK20.43963847
95SGK30.42691623
96PRKD10.42545397
97FYN0.40673983
98JAK10.40527004
99DAPK30.40314500
100JAK20.36312915

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046113.38823226
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.50207123
3ECM-receptor interaction_Homo sapiens_hsa045122.26568796
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.11437404
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69339516
6Hematopoietic cell lineage_Homo sapiens_hsa046401.69116213
7Leukocyte transendothelial migration_Homo sapiens_hsa046701.63927164
8Shigellosis_Homo sapiens_hsa051311.63545232
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56405207
10Amoebiasis_Homo sapiens_hsa051461.55967422
11Focal adhesion_Homo sapiens_hsa045101.50350423
12Pancreatic cancer_Homo sapiens_hsa052121.49638261
13Osteoclast differentiation_Homo sapiens_hsa043801.48859208
14Malaria_Homo sapiens_hsa051441.45221501
15Chemokine signaling pathway_Homo sapiens_hsa040621.42894457
16Small cell lung cancer_Homo sapiens_hsa052221.42716428
17Regulation of actin cytoskeleton_Homo sapiens_hsa048101.41533001
18B cell receptor signaling pathway_Homo sapiens_hsa046621.41394834
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39699254
20Endocytosis_Homo sapiens_hsa041441.38979079
21VEGF signaling pathway_Homo sapiens_hsa043701.36272271
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33439103
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29357898
24Adherens junction_Homo sapiens_hsa045201.26268205
25Arachidonic acid metabolism_Homo sapiens_hsa005901.26015097
26Non-small cell lung cancer_Homo sapiens_hsa052231.25423554
27Chronic myeloid leukemia_Homo sapiens_hsa052201.22078769
28Acute myeloid leukemia_Homo sapiens_hsa052211.21103604
29Leishmaniasis_Homo sapiens_hsa051401.18692461
30Renal cell carcinoma_Homo sapiens_hsa052111.14844614
31Bladder cancer_Homo sapiens_hsa052191.14114857
32Choline metabolism in cancer_Homo sapiens_hsa052311.12485569
33Toxoplasmosis_Homo sapiens_hsa051451.11796637
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10657760
35Endometrial cancer_Homo sapiens_hsa052131.10174141
36Salmonella infection_Homo sapiens_hsa051321.09359886
37Thyroid cancer_Homo sapiens_hsa052161.09019974
38Notch signaling pathway_Homo sapiens_hsa043301.08318085
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05702747
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.03947450
41Phagosome_Homo sapiens_hsa041451.03345266
42Gap junction_Homo sapiens_hsa045401.00563602
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00467465
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.00352222
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00007746
46Tuberculosis_Homo sapiens_hsa051520.99359859
47Proteoglycans in cancer_Homo sapiens_hsa052050.99205869
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94219438
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.93628418
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93453994
51T cell receptor signaling pathway_Homo sapiens_hsa046600.92521806
52Rap1 signaling pathway_Homo sapiens_hsa040150.87445282
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87368323
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86984223
55TNF signaling pathway_Homo sapiens_hsa046680.86933035
56Apoptosis_Homo sapiens_hsa042100.86119035
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85603068
58Lysosome_Homo sapiens_hsa041420.82689297
59Legionellosis_Homo sapiens_hsa051340.82498881
60ErbB signaling pathway_Homo sapiens_hsa040120.81984625
61Glioma_Homo sapiens_hsa052140.81530028
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.81504710
63Hepatitis C_Homo sapiens_hsa051600.79669135
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78451012
65GnRH signaling pathway_Homo sapiens_hsa049120.77489719
66Influenza A_Homo sapiens_hsa051640.76225187
67Long-term depression_Homo sapiens_hsa047300.75428085
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74345452
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.73249520
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.71573312
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71378826
72Staphylococcus aureus infection_Homo sapiens_hsa051500.70140211
73Pathways in cancer_Homo sapiens_hsa052000.68912459
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68591553
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67975038
76Sphingolipid metabolism_Homo sapiens_hsa006000.67284740
77Pentose phosphate pathway_Homo sapiens_hsa000300.67016646
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65603033
79Hepatitis B_Homo sapiens_hsa051610.65188966
80Pertussis_Homo sapiens_hsa051330.63027415
81Measles_Homo sapiens_hsa051620.62077761
82Inositol phosphate metabolism_Homo sapiens_hsa005620.61207509
83Ras signaling pathway_Homo sapiens_hsa040140.61124713
84Pancreatic secretion_Homo sapiens_hsa049720.60885223
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60667833
86Dilated cardiomyopathy_Homo sapiens_hsa054140.60332614
87Viral carcinogenesis_Homo sapiens_hsa052030.59956945
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.58935884
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58787613
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.57688496
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57470160
92Serotonergic synapse_Homo sapiens_hsa047260.56460390
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56235375
94Insulin signaling pathway_Homo sapiens_hsa049100.54815969
95African trypanosomiasis_Homo sapiens_hsa051430.54630917
96Galactose metabolism_Homo sapiens_hsa000520.54289418
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.53071817
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52717130
99Prostate cancer_Homo sapiens_hsa052150.51940219
100HIF-1 signaling pathway_Homo sapiens_hsa040660.51710823

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