ZNF189

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.29229774
2nerve growth factor signaling pathway (GO:0038180)4.24836086
3response to follicle-stimulating hormone (GO:0032354)4.04722156
4plasma lipoprotein particle assembly (GO:0034377)3.51036553
5positive regulation of muscle hypertrophy (GO:0014742)3.45080404
6positive regulation of cardiac muscle hypertrophy (GO:0010613)3.45080404
7response to nerve growth factor (GO:1990089)3.42695959
8cellular response to nerve growth factor stimulus (GO:1990090)3.42695959
9intracellular lipid transport (GO:0032365)3.39387627
10negative regulation of protein activation cascade (GO:2000258)3.31725940
11cellular response to antibiotic (GO:0071236)3.25497016
12protein-lipid complex assembly (GO:0065005)3.21375303
13gastrulation with mouth forming second (GO:0001702)3.16664991
14very-low-density lipoprotein particle assembly (GO:0034379)3.13962727
15negative regulation of complement activation (GO:0045916)3.09806357
16cholesterol efflux (GO:0033344)3.06117440
17regulation of fibrinolysis (GO:0051917)3.01232562
18cellular response to gonadotropin stimulus (GO:0071371)2.99587815
19phospholipid homeostasis (GO:0055091)2.95341513
20embryonic retina morphogenesis in camera-type eye (GO:0060059)2.94684153
21iron ion import (GO:0097286)2.84109921
22relaxation of cardiac muscle (GO:0055119)2.83052357
23cardiac muscle adaptation (GO:0014887)2.80054004
24cardiac muscle hypertrophy in response to stress (GO:0014898)2.80054004
25muscle hypertrophy in response to stress (GO:0003299)2.80054004
26regulation of protein activation cascade (GO:2000257)2.77544863
27cardiac muscle hypertrophy (GO:0003300)2.77340010
28cellular response to ethanol (GO:0071361)2.77313142
29phospholipid efflux (GO:0033700)2.76624174
30glycoprotein catabolic process (GO:0006516)2.75261444
31regulation of complement activation (GO:0030449)2.74112528
32phospholipid translocation (GO:0045332)2.73006328
33lipid translocation (GO:0034204)2.73006328
34negative regulation of keratinocyte proliferation (GO:0010839)2.71856424
35cardiac myofibril assembly (GO:0055003)2.67283074
36regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.67082814
37establishment of nucleus localization (GO:0040023)2.67061398
38plasma lipoprotein particle remodeling (GO:0034369)2.66927596
39protein-lipid complex remodeling (GO:0034368)2.66927596
40macromolecular complex remodeling (GO:0034367)2.66927596
41reverse cholesterol transport (GO:0043691)2.66114120
42cellular response to toxic substance (GO:0097237)2.64508461
43negative regulation of fibrinolysis (GO:0051918)2.64445977
44plasma lipoprotein particle organization (GO:0071827)2.62429635
45striated muscle hypertrophy (GO:0014897)2.58529640
46plasma lipoprotein particle clearance (GO:0034381)2.58076178
47regulation of cholesterol esterification (GO:0010872)2.57691591
48high-density lipoprotein particle remodeling (GO:0034375)2.54367990
49interleukin-6-mediated signaling pathway (GO:0070102)2.52548779
50protein-lipid complex subunit organization (GO:0071825)2.51620888
51regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.51447106
52positive regulation of dendritic spine morphogenesis (GO:0061003)2.50786644
53sterol transport (GO:0015918)2.49840708
54cholesterol transport (GO:0030301)2.49840708
55low-density lipoprotein particle remodeling (GO:0034374)2.49351049
56low-density lipoprotein particle clearance (GO:0034383)2.48409159
57negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.47817118
58protein targeting to lysosome (GO:0006622)2.47001029
59establishment of protein localization to vacuole (GO:0072666)2.47001029
60protein targeting to vacuole (GO:0006623)2.47001029
61response to lipoprotein particle (GO:0055094)2.46592309
62positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.44734039
63regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.44251088
64regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.41823661
65regulation of heat generation (GO:0031650)2.40796270
66regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.40723803
67negative regulation of neurotransmitter secretion (GO:0046929)2.39871509
68regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.39681041
69regulation of apoptotic cell clearance (GO:2000425)2.39678655
70regulation of cardiac muscle hypertrophy (GO:0010611)2.38126239
71dendrite morphogenesis (GO:0048813)2.34691505
72cell proliferation involved in kidney development (GO:0072111)2.34420700
73myofibril assembly (GO:0030239)2.33737881
74glucocorticoid metabolic process (GO:0008211)2.33011006
75amino-acid betaine transport (GO:0015838)2.32617156
76carnitine transport (GO:0015879)2.32617156
77positive regulation of cardiac muscle tissue growth (GO:0055023)2.32141401
78regulation of dendritic spine development (GO:0060998)2.30756356
79cellular response to fluid shear stress (GO:0071498)2.30304540
80axonal fasciculation (GO:0007413)2.30157833
81positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.29950946
82regulation of muscle hypertrophy (GO:0014743)2.29006478
83regulation of plasminogen activation (GO:0010755)2.27603113
84artery development (GO:0060840)2.27567365
85regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.26047270
86negative regulation of humoral immune response (GO:0002921)2.24846024
87negative chemotaxis (GO:0050919)2.24497424
88regulation of protein kinase A signaling (GO:0010738)2.23045552
89positive regulation of heart growth (GO:0060421)2.22759054
90response to epinephrine (GO:0071871)2.21096062
91response to gonadotropin (GO:0034698)2.18841249
92negative regulation of lipase activity (GO:0060192)2.18754596
93presynaptic membrane organization (GO:0097090)2.17841307
94positive regulation of dendritic spine development (GO:0060999)2.17754022
95response to methylmercury (GO:0051597)2.17681636
96intestinal cholesterol absorption (GO:0030299)2.15973209
97negative regulation of sodium ion transport (GO:0010766)2.15957847
98regulation of steroid hormone biosynthetic process (GO:0090030)2.15647326
99negative regulation of cholesterol transport (GO:0032375)2.15639739
100negative regulation of sterol transport (GO:0032372)2.15639739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.12581088
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.96632474
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.91510143
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.74696343
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.65361562
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.63710648
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.42382826
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.39992246
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.34073181
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27619870
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16748092
12EZH2_22144423_ChIP-Seq_EOC_Human2.11594441
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04681314
14PIAS1_25552417_ChIP-Seq_VCAP_Human2.03831020
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03239624
16WT1_19549856_ChIP-ChIP_CCG9911_Human1.99252028
17TAF15_26573619_Chip-Seq_HEK293_Human1.94203995
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91914434
19EP300_21415370_ChIP-Seq_HL-1_Mouse1.89333398
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84049662
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77574581
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75347166
23SMAD4_21799915_ChIP-Seq_A2780_Human1.71867713
24SMAD3_21741376_ChIP-Seq_EPCs_Human1.71036340
25TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.67578461
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67015805
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67001950
28TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.65523365
29FUS_26573619_Chip-Seq_HEK293_Human1.62277646
30P300_19829295_ChIP-Seq_ESCs_Human1.61506223
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60114085
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60114085
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58160966
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.52911758
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51590566
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.51402683
37STAT3_23295773_ChIP-Seq_U87_Human1.51365856
38SMAD3_21741376_ChIP-Seq_HESCs_Human1.50782065
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49736186
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49469328
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46909344
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.44839490
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44359324
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43742298
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43376956
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41506476
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.40099080
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38450211
49TP53_16413492_ChIP-PET_HCT116_Human1.38084806
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.35869402
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35264694
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35153827
53LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33386472
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33313199
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32008565
56E2F1_18555785_Chip-Seq_ESCs_Mouse1.31671723
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29894788
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29782521
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29473883
60RXR_22108803_ChIP-Seq_LS180_Human1.28601216
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28462844
62YAP1_20516196_ChIP-Seq_MESCs_Mouse1.28169850
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25761383
64TP53_18474530_ChIP-ChIP_U2OS_Human1.23910819
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.22615313
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22436311
67P53_22387025_ChIP-Seq_ESCs_Mouse1.22061065
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21793542
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.21430863
70TCF4_23295773_ChIP-Seq_U87_Human1.21396024
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21048286
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20876636
73AR_21572438_ChIP-Seq_LNCaP_Human1.19133859
74SMAD4_21741376_ChIP-Seq_HESCs_Human1.19036640
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18018153
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.17949459
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14238217
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.13060907
79GATA1_22025678_ChIP-Seq_K562_Human1.10569839
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10546807
81TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10166613
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.09749470
83EWS_26573619_Chip-Seq_HEK293_Human1.09399428
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08392341
85KDM2B_26808549_Chip-Seq_REH_Human1.06537838
86SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06280563
87P300_18555785_Chip-Seq_ESCs_Mouse1.05134625
88EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04271219
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03654033
90RUNX2_22187159_ChIP-Seq_PCA_Human1.03617673
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03434971
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.03352728
93AHR_22903824_ChIP-Seq_MCF-7_Human1.02407779
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.02027208
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01938204
96CJUN_26792858_Chip-Seq_BT549_Human1.01348773
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01137954
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00678927
99OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00276554
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.00111923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.48187241
2MP0005451_abnormal_body_composition3.47149924
3MP0008004_abnormal_stomach_pH3.25852434
4MP0009840_abnormal_foam_cell3.10704363
5MP0003890_abnormal_embryonic-extraembry2.84649600
6MP0003690_abnormal_glial_cell2.54903558
7MP0002139_abnormal_hepatobiliary_system2.34126247
8MP0003868_abnormal_feces_composition2.32489592
9MP0004270_analgesia2.30101398
10MP0000569_abnormal_digit_pigmentation2.19115240
11MP0003122_maternal_imprinting2.16576690
12MP0001299_abnormal_eye_distance/2.11974156
13MP0003183_abnormal_peptide_metabolism2.11423643
14MP0005365_abnormal_bile_salt2.09976357
15MP0000462_abnormal_digestive_system2.07573908
16MP0003950_abnormal_plasma_membrane2.03280005
17MP0000566_synostosis1.98002076
18MP0003943_abnormal_hepatobiliary_system1.97334983
19MP0004147_increased_porphyrin_level1.94910490
20MP0001666_abnormal_nutrient_absorption1.90055077
21MP0000778_abnormal_nervous_system1.84122948
22MP0004043_abnormal_pH_regulation1.83316228
23MP0010329_abnormal_lipoprotein_level1.80877266
24MP0005187_abnormal_penis_morphology1.52176157
25MP0004859_abnormal_synaptic_plasticity1.51175273
26MP0002233_abnormal_nose_morphology1.39046109
27MP0000920_abnormal_myelination1.38110287
28MP0003283_abnormal_digestive_organ1.37331893
29MP0002090_abnormal_vision1.36499112
30MP0001501_abnormal_sleep_pattern1.34952034
31MP0002638_abnormal_pupillary_reflex1.27376932
32MP0003632_abnormal_nervous_system1.26737037
33MP0006138_congestive_heart_failure1.25991697
34MP0002127_abnormal_cardiovascular_syste1.25255480
35MP0000604_amyloidosis1.23292348
36MP0002168_other_aberrant_phenotype1.22051838
37MP0003941_abnormal_skin_development1.20721581
38MP0002138_abnormal_hepatobiliary_system1.19944458
39MP0003091_abnormal_cell_migration1.19684061
40MP0003385_abnormal_body_wall1.18630238
41MP0000534_abnormal_ureter_morphology1.15588849
42MP0005646_abnormal_pituitary_gland1.15122478
43MP0003634_abnormal_glial_cell1.13474414
44MP0003329_amyloid_beta_deposits1.12724499
45MP0005085_abnormal_gallbladder_physiolo1.11066953
46MP0002876_abnormal_thyroid_physiology1.10781952
47MP0003942_abnormal_urinary_system1.10781297
48MP0003656_abnormal_erythrocyte_physiolo1.09452492
49MP0001849_ear_inflammation1.08383447
50MP0005248_abnormal_Harderian_gland1.06688086
51MP0006054_spinal_hemorrhage1.05789476
52MP0001486_abnormal_startle_reflex1.04713977
53MP0005367_renal/urinary_system_phenotyp1.03769809
54MP0000516_abnormal_urinary_system1.03769809
55MP0004272_abnormal_basement_membrane1.02899542
56MP0003633_abnormal_nervous_system1.00411389
57MP0004885_abnormal_endolymph0.98411517
58MP0002735_abnormal_chemical_nociception0.96865200
59MP0004084_abnormal_cardiac_muscle0.96637743
60MP0003935_abnormal_craniofacial_develop0.95663471
61MP0006276_abnormal_autonomic_nervous0.95504604
62MP0010630_abnormal_cardiac_muscle0.94993227
63MP0005409_darkened_coat_color0.94580333
64MP0000639_abnormal_adrenal_gland0.93608870
65MP0000733_abnormal_muscle_development0.92977029
66MP0003880_abnormal_central_pattern0.92756034
67MP0002909_abnormal_adrenal_gland0.90775243
68MP0002896_abnormal_bone_mineralization0.90243457
69MP0005395_other_phenotype0.89490558
70MP0010307_abnormal_tumor_latency0.89177058
71MP0002118_abnormal_lipid_homeostasis0.88973262
72MP0001915_intracranial_hemorrhage0.88653205
73MP0009046_muscle_twitch0.88103982
74MP0004085_abnormal_heartbeat0.87658419
75MP0003631_nervous_system_phenotype0.87530597
76MP0005253_abnormal_eye_physiology0.86910404
77MP0001177_atelectasis0.85110348
78MP0000767_abnormal_smooth_muscle0.84335701
79MP0003635_abnormal_synaptic_transmissio0.83389129
80MP0000428_abnormal_craniofacial_morphol0.81658618
81MP0003303_peritoneal_inflammation0.80486331
82MP0002734_abnormal_mechanical_nocicepti0.80122152
83MP0004484_altered_response_of0.79760454
84MP0001984_abnormal_olfaction0.78571146
85MP0004510_myositis0.75042313
86MP0004215_abnormal_myocardial_fiber0.74449436
87MP0003191_abnormal_cellular_cholesterol0.74137920
88MP0003879_abnormal_hair_cell0.73462207
89MP0003567_abnormal_fetal_cardiomyocyte0.73313284
90MP0001440_abnormal_grooming_behavior0.71978742
91MP0003937_abnormal_limbs/digits/tail_de0.71606207
92MP0002092_abnormal_eye_morphology0.71466664
93MP0005386_behavior/neurological_phenoty0.71288046
94MP0004924_abnormal_behavior0.71288046
95MP0003300_gastrointestinal_ulcer0.70454521
96MP0002064_seizures0.69092472
97MP0004036_abnormal_muscle_relaxation0.68735258
98MP0002697_abnormal_eye_size0.66880060
99MP0003828_pulmonary_edema0.66662437
100MP0002822_catalepsy0.65990193

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)4.08641685
2Diastasis recti (HP:0001540)3.75912410
3Abnormal pancreas size (HP:0012094)3.69653803
4Abnormality of the intrinsic pathway (HP:0010989)3.61349529
5Hypoalphalipoproteinemia (HP:0003233)3.55293316
6Central scotoma (HP:0000603)3.31663565
7Papillary thyroid carcinoma (HP:0002895)3.27762610
8Deep venous thrombosis (HP:0002625)3.22164789
9Overlapping toe (HP:0001845)3.10964373
10Hypolipoproteinemia (HP:0010981)3.01411068
11Gonadal dysgenesis (HP:0000133)2.88070312
12Abnormality of macular pigmentation (HP:0008002)2.73698446
13Hepatoblastoma (HP:0002884)2.69817374
14Increased number of teeth (HP:0011069)2.64601419
15Febrile seizures (HP:0002373)2.56452681
16Epidermoid cyst (HP:0200040)2.50012992
17Abnormality of the common coagulation pathway (HP:0010990)2.41781602
18Complement deficiency (HP:0004431)2.40918583
19Abnormality of the ischium (HP:0003174)2.36495883
20Glomerulonephritis (HP:0000099)2.35919757
21Joint hemorrhage (HP:0005261)2.35876976
22Broad-based gait (HP:0002136)2.33748552
23Anomalous pulmonary venous return (HP:0010772)2.31667267
24Scotoma (HP:0000575)2.28850454
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.27678510
26Conjunctival telangiectasia (HP:0000524)2.25616971
27Intrahepatic cholestasis (HP:0001406)2.24704610
28Hypobetalipoproteinemia (HP:0003563)2.20362059
29Cutaneous finger syndactyly (HP:0010554)2.16024998
30Severe visual impairment (HP:0001141)2.15968283
31Proximal tubulopathy (HP:0000114)2.12774351
32Hypoglycemic coma (HP:0001325)2.12737255
33Overgrowth (HP:0001548)2.12505519
34Pulmonic stenosis (HP:0001642)2.12457202
35Bundle branch block (HP:0011710)2.10698039
36Osteomalacia (HP:0002749)2.08050155
37Limited hip movement (HP:0008800)2.05886014
38Spontaneous abortion (HP:0005268)2.05659850
39Abnormality of the pulmonary veins (HP:0011718)2.02244296
40Wide anterior fontanel (HP:0000260)2.01517267
41Albinism (HP:0001022)2.01209835
42Abnormality of the lumbar spine (HP:0100712)2.00444251
43Renal cortical cysts (HP:0000803)2.00114424
44Sudden death (HP:0001699)1.98831558
45Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97872893
46Difficulty running (HP:0009046)1.96999567
47Coronal craniosynostosis (HP:0004440)1.96287060
48Choroideremia (HP:0001139)1.95065525
49Arterial tortuosity (HP:0005116)1.93861369
50Bifid tongue (HP:0010297)1.91162354
51Neurofibrillary tangles (HP:0002185)1.88811940
52Midline defect of the nose (HP:0004122)1.87790525
53Arthropathy (HP:0003040)1.86303203
54Hypercholesterolemia (HP:0003124)1.85324110
55Preauricular pit (HP:0004467)1.85078621
56Periauricular skin pits (HP:0100277)1.85078621
57Fair hair (HP:0002286)1.83639406
58Abnormality of carpal bone ossification (HP:0006257)1.82332696
59Atonic seizures (HP:0010819)1.81660460
60Anteriorly placed anus (HP:0001545)1.81647719
61Acute myeloid leukemia (HP:0004808)1.80427005
62Cutaneous syndactyly (HP:0012725)1.80266860
63Supernumerary spleens (HP:0009799)1.80055298
64Abnormal tarsal ossification (HP:0008369)1.79883259
65Xanthomatosis (HP:0000991)1.78556429
66Thyroid carcinoma (HP:0002890)1.78522478
67Drooling (HP:0002307)1.78456419
68Cubitus valgus (HP:0002967)1.78271762
69Abnormal ventriculo-arterial connection (HP:0011563)1.78254621
70Transposition of the great arteries (HP:0001669)1.78254621
71Abnormal connection of the cardiac segments (HP:0011545)1.78254621
72Short metatarsal (HP:0010743)1.75522417
73Fat malabsorption (HP:0002630)1.75342174
74Lymphangioma (HP:0100764)1.73298144
75Exotropia (HP:0000577)1.73239259
76Mitral stenosis (HP:0001718)1.73073931
77Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70886105
78Short 4th metacarpal (HP:0010044)1.70886105
79Hypophosphatemic rickets (HP:0004912)1.69660455
80Tubulointerstitial abnormality (HP:0001969)1.66324171
81Absent eyebrow (HP:0002223)1.66028846
82Congenital malformation of the right heart (HP:0011723)1.65242147
83Double outlet right ventricle (HP:0001719)1.65242147
84Vascular tortuosity (HP:0004948)1.64708737
85Hypoplastic ischia (HP:0003175)1.64390455
86Heterotopia (HP:0002282)1.64116109
87Excessive salivation (HP:0003781)1.62000868
88Relative macrocephaly (HP:0004482)1.60998374
89Wide nose (HP:0000445)1.59625933
90Facial hemangioma (HP:0000329)1.58620619
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.58407244
92Preaxial foot polydactyly (HP:0001841)1.58079446
93Pancreatic islet-cell hyperplasia (HP:0004510)1.58033305
94Flat face (HP:0012368)1.56325942
95Gonadotropin excess (HP:0000837)1.56104226
96Tubulointerstitial fibrosis (HP:0005576)1.55391518
97Large earlobe (HP:0009748)1.54743073
98Capillary hemangiomas (HP:0005306)1.54448208
99Abnormality of the pubic bones (HP:0003172)1.54146848
100Lower limb muscle weakness (HP:0007340)1.53425418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.08554632
2LATS14.59727715
3PRKD32.59473734
4BRD42.58550272
5AKT32.50408715
6STK38L2.44874047
7INSRR2.37943171
8DMPK2.35518676
9ICK2.25185949
10EPHA42.00565723
11EIF2AK31.89153307
12NUAK11.87192591
13PDGFRA1.81280796
14CDC42BPA1.77819960
15LATS21.70951448
16MATK1.69931088
17DDR21.56591219
18OBSCN1.53336192
19FGFR31.50560573
20WNK11.49810528
21STK241.46715863
22PRPF4B1.45887302
23NEK91.44117244
24PNCK1.35388894
25TNIK1.34428607
26NTRK31.34070209
27CDK121.32749636
28STK31.32149632
29TYRO31.25226449
30STK391.23066098
31SGK21.20867203
32CAMK1G1.15615754
33RIPK11.11876852
34SIK21.08998153
35FRK1.06541441
36MAPK71.02808720
37PDGFRB0.95627049
38PINK10.90855755
39TGFBR20.87801058
40FGFR40.86122426
41BLK0.80994219
42SGK30.79969027
43MAP3K50.78359217
44BCR0.77893254
45SGK2230.77766090
46SGK4940.77766090
47MAPK100.74546358
48MAP3K90.71412940
49MAPK130.71044777
50FGFR10.70143955
51STK380.69354037
52MARK10.68789956
53RPS6KB10.67677345
54NTRK10.66945830
55FGFR20.64933663
56PRKAA20.62535271
57MET0.62061676
58ROCK10.61914186
59YES10.60304479
60PAK30.59865090
61ROCK20.58558063
62PRKACB0.57985993
63PRKD20.57945961
64PIK3CA0.57878325
65TRPM70.56929976
66MELK0.56855106
67FGR0.56554552
68NLK0.56105744
69MAP3K120.54538365
70RAF10.53595939
71FER0.52119689
72CDK50.51676792
73JAK10.50725493
74ACVR1B0.49175393
75OXSR10.47366474
76MAP3K20.47259133
77CAMK1D0.46992333
78SGK10.46967207
79PRKCE0.45118039
80CSNK1E0.43561078
81PRKG10.42784740
82MAPK120.41657945
83CAMK2A0.39145628
84PDK20.38661770
85MAP3K40.37723994
86MKNK20.37416928
87DYRK1A0.37087879
88CSNK1G10.36525624
89DAPK20.36340971
90PRKCZ0.36098795
91RPS6KA30.36031410
92CSNK1D0.35513557
93PRKDC0.35278444
94CDK60.35263051
95MAP3K70.34898436
96MARK20.34820586
97PKN10.33540486
98PRKCH0.33511342
99MAP3K140.32729367
100KIT0.32600849

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046102.91756754
2Fatty acid biosynthesis_Homo sapiens_hsa000612.10840208
3Histidine metabolism_Homo sapiens_hsa003401.87502482
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68919475
5Sphingolipid metabolism_Homo sapiens_hsa006001.67508658
6Circadian rhythm_Homo sapiens_hsa047101.59650404
7PPAR signaling pathway_Homo sapiens_hsa033201.54302662
8Steroid biosynthesis_Homo sapiens_hsa001001.39822063
9ABC transporters_Homo sapiens_hsa020101.35375103
10Fat digestion and absorption_Homo sapiens_hsa049751.35221769
11Renin secretion_Homo sapiens_hsa049241.33243588
12Fatty acid metabolism_Homo sapiens_hsa012121.28453479
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22080595
14Bile secretion_Homo sapiens_hsa049761.21681021
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18427032
16Dilated cardiomyopathy_Homo sapiens_hsa054141.17397016
17Fatty acid degradation_Homo sapiens_hsa000711.16437373
18TGF-beta signaling pathway_Homo sapiens_hsa043501.15682154
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15513475
20Dorso-ventral axis formation_Homo sapiens_hsa043201.13693752
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.13422304
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13319948
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12658316
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11621699
25Renin-angiotensin system_Homo sapiens_hsa046141.11498590
26Circadian entrainment_Homo sapiens_hsa047131.09854820
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09454552
28Long-term potentiation_Homo sapiens_hsa047201.08754822
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.06801248
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04407033
31Glutamatergic synapse_Homo sapiens_hsa047241.00035493
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99773202
33GABAergic synapse_Homo sapiens_hsa047270.98562187
34Tight junction_Homo sapiens_hsa045300.97694303
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95512043
36Prion diseases_Homo sapiens_hsa050200.93666578
37Pancreatic secretion_Homo sapiens_hsa049720.90574181
38Propanoate metabolism_Homo sapiens_hsa006400.90136437
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89650837
40Steroid hormone biosynthesis_Homo sapiens_hsa001400.89238233
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88821808
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88235171
43Ovarian steroidogenesis_Homo sapiens_hsa049130.87883195
44Vitamin digestion and absorption_Homo sapiens_hsa049770.87829634
45Nicotine addiction_Homo sapiens_hsa050330.86400420
46Lysine degradation_Homo sapiens_hsa003100.86353379
47cAMP signaling pathway_Homo sapiens_hsa040240.86013455
48Inositol phosphate metabolism_Homo sapiens_hsa005620.85601975
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84634860
50Mineral absorption_Homo sapiens_hsa049780.84411345
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84169598
52Arginine biosynthesis_Homo sapiens_hsa002200.84013379
53Protein digestion and absorption_Homo sapiens_hsa049740.83944035
54Starch and sucrose metabolism_Homo sapiens_hsa005000.83099524
55Adherens junction_Homo sapiens_hsa045200.82865485
56ECM-receptor interaction_Homo sapiens_hsa045120.80914100
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76945840
58Insulin secretion_Homo sapiens_hsa049110.76773983
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75772944
60Butanoate metabolism_Homo sapiens_hsa006500.75610967
61Type II diabetes mellitus_Homo sapiens_hsa049300.75037879
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73175157
63N-Glycan biosynthesis_Homo sapiens_hsa005100.72970266
64Focal adhesion_Homo sapiens_hsa045100.71771440
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.71224491
66Taste transduction_Homo sapiens_hsa047420.70219949
67ErbB signaling pathway_Homo sapiens_hsa040120.69360446
68beta-Alanine metabolism_Homo sapiens_hsa004100.69336911
69Staphylococcus aureus infection_Homo sapiens_hsa051500.69013103
70Lysosome_Homo sapiens_hsa041420.68450698
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.67599217
72Amoebiasis_Homo sapiens_hsa051460.67152893
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66292754
74Calcium signaling pathway_Homo sapiens_hsa040200.64676063
75GnRH signaling pathway_Homo sapiens_hsa049120.64287542
76Cholinergic synapse_Homo sapiens_hsa047250.63852528
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63469400
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.63217679
79Phenylalanine metabolism_Homo sapiens_hsa003600.63118061
80Gap junction_Homo sapiens_hsa045400.62978764
81Thyroid hormone synthesis_Homo sapiens_hsa049180.62728769
82Dopaminergic synapse_Homo sapiens_hsa047280.62658824
83Axon guidance_Homo sapiens_hsa043600.62514230
84Prolactin signaling pathway_Homo sapiens_hsa049170.60635665
85Oxytocin signaling pathway_Homo sapiens_hsa049210.60476278
86FoxO signaling pathway_Homo sapiens_hsa040680.59458770
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.57663009
88Proteoglycans in cancer_Homo sapiens_hsa052050.57276573
89Hippo signaling pathway_Homo sapiens_hsa043900.55745790
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55419344
91MAPK signaling pathway_Homo sapiens_hsa040100.55353435
92Nitrogen metabolism_Homo sapiens_hsa009100.54933864
93MicroRNAs in cancer_Homo sapiens_hsa052060.53766758
94Rap1 signaling pathway_Homo sapiens_hsa040150.52690376
95Renal cell carcinoma_Homo sapiens_hsa052110.52292701
96Chronic myeloid leukemia_Homo sapiens_hsa052200.51866253
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50375327
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.49955490
99Tryptophan metabolism_Homo sapiens_hsa003800.49906656
100Gastric acid secretion_Homo sapiens_hsa049710.49726008

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