ZNF19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a zinc finger, a nucleic acid-binding domain present in many transcription factors. This gene is located in a region next to ZNF23, a gene also encoding a zinc finger protein, on chromosome 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.21551912
2response to pheromone (GO:0019236)4.51347125
3cilium or flagellum-dependent cell motility (GO:0001539)4.28886190
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.27969534
5epithelial cilium movement (GO:0003351)4.16885179
6cellular ketone body metabolic process (GO:0046950)4.00566378
7fucose catabolic process (GO:0019317)3.84243126
8L-fucose metabolic process (GO:0042354)3.84243126
9L-fucose catabolic process (GO:0042355)3.84243126
10protein polyglutamylation (GO:0018095)3.82668813
11cilium movement (GO:0003341)3.77865338
12detection of light stimulus involved in visual perception (GO:0050908)3.72849225
13detection of light stimulus involved in sensory perception (GO:0050962)3.72849225
14nonmotile primary cilium assembly (GO:0035058)3.72695084
15regulation of cilium movement (GO:0003352)3.70272924
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.68442744
17ketone body metabolic process (GO:1902224)3.64919438
18axoneme assembly (GO:0035082)3.64119448
19indolalkylamine catabolic process (GO:0046218)3.63970083
20tryptophan catabolic process (GO:0006569)3.63970083
21indole-containing compound catabolic process (GO:0042436)3.63970083
22indolalkylamine metabolic process (GO:0006586)3.54333478
23protein localization to cilium (GO:0061512)3.48995351
24kynurenine metabolic process (GO:0070189)3.47745942
25retinal cone cell development (GO:0046549)3.39274404
26protein K11-linked deubiquitination (GO:0035871)3.35796890
27photoreceptor cell maintenance (GO:0045494)3.34326862
28neural tube formation (GO:0001841)3.31658676
29sperm motility (GO:0030317)3.30909243
30cilium organization (GO:0044782)3.30314280
31tryptophan metabolic process (GO:0006568)3.25009077
32cilium assembly (GO:0042384)3.21574893
33cilium morphogenesis (GO:0060271)3.20456194
34intraciliary transport (GO:0042073)3.20368542
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.19472925
36multicellular organism reproduction (GO:0032504)3.16174846
37axonemal dynein complex assembly (GO:0070286)3.15694833
38piRNA metabolic process (GO:0034587)3.13176371
39reflex (GO:0060004)3.03671274
40pyrimidine nucleobase catabolic process (GO:0006208)2.99478937
41platelet dense granule organization (GO:0060155)2.98281197
42acrosome reaction (GO:0007340)2.94582093
43sulfation (GO:0051923)2.92964474
44regulation of glucokinase activity (GO:0033131)2.90825901
45regulation of hexokinase activity (GO:1903299)2.90825901
46neuronal action potential (GO:0019228)2.90734678
47gamma-aminobutyric acid transport (GO:0015812)2.90319259
48negative regulation of telomere maintenance (GO:0032205)2.87366841
49negative regulation of translation, ncRNA-mediated (GO:0040033)2.87119840
50regulation of translation, ncRNA-mediated (GO:0045974)2.87119840
51negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87119840
52nucleobase catabolic process (GO:0046113)2.83154637
53regulation of microtubule-based movement (GO:0060632)2.81494993
54DNA double-strand break processing (GO:0000729)2.76667016
55regulation of action potential (GO:0098900)2.76666807
56DNA deamination (GO:0045006)2.75858712
57DNA methylation involved in gamete generation (GO:0043046)2.74431691
58transmission of nerve impulse (GO:0019226)2.73598999
59indole-containing compound metabolic process (GO:0042430)2.71638580
60amine catabolic process (GO:0009310)2.70864236
61cellular biogenic amine catabolic process (GO:0042402)2.70864236
62water-soluble vitamin biosynthetic process (GO:0042364)2.70570636
63mannosylation (GO:0097502)2.69010363
64cornea development in camera-type eye (GO:0061303)2.66849780
65positive regulation of oligodendrocyte differentiation (GO:0048714)2.61896049
66photoreceptor cell development (GO:0042461)2.60913707
67primary amino compound metabolic process (GO:1901160)2.60759450
68protein-cofactor linkage (GO:0018065)2.59587183
69centriole replication (GO:0007099)2.59529444
70inner ear receptor stereocilium organization (GO:0060122)2.57692925
71signal peptide processing (GO:0006465)2.56667367
72synaptic transmission, cholinergic (GO:0007271)2.55789730
73retinal ganglion cell axon guidance (GO:0031290)2.54901999
74cellular component assembly involved in morphogenesis (GO:0010927)2.53949233
75male meiosis (GO:0007140)2.52556780
76proline transport (GO:0015824)2.50052397
77rRNA catabolic process (GO:0016075)2.48587179
78auditory receptor cell stereocilium organization (GO:0060088)2.47129665
79spermatid development (GO:0007286)2.46134587
80smoothened signaling pathway (GO:0007224)2.45443083
81establishment of protein localization to Golgi (GO:0072600)2.45189212
82regulation of hippo signaling (GO:0035330)2.45169680
83benzene-containing compound metabolic process (GO:0042537)2.45044637
84replication fork processing (GO:0031297)2.44770852
85negative regulation of transcription regulatory region DNA binding (GO:2000678)2.44603213
86reciprocal DNA recombination (GO:0035825)2.44238678
87reciprocal meiotic recombination (GO:0007131)2.44238678
88respiratory chain complex IV assembly (GO:0008535)2.43330205
89kidney morphogenesis (GO:0060993)2.42171061
90serotonin metabolic process (GO:0042428)2.40714772
91recombinational repair (GO:0000725)2.40621053
92negative regulation of cytosolic calcium ion concentration (GO:0051481)2.39336383
93membrane depolarization during action potential (GO:0086010)2.38826354
94preassembly of GPI anchor in ER membrane (GO:0016254)2.38317325
95glycosphingolipid biosynthetic process (GO:0006688)2.37933802
96behavioral response to ethanol (GO:0048149)2.37578027
97eye photoreceptor cell development (GO:0042462)2.37265586
98regulation of telomere maintenance (GO:0032204)2.37152734
99double-strand break repair via homologous recombination (GO:0000724)2.37052092
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.36944328

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.00893788
2ZNF274_21170338_ChIP-Seq_K562_Hela3.64085827
3GBX2_23144817_ChIP-Seq_PC3_Human3.25914831
4VDR_22108803_ChIP-Seq_LS180_Human3.10690255
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77032620
6IGF1R_20145208_ChIP-Seq_DFB_Human2.63705622
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58709151
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50954325
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.44247774
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31605800
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19853367
12P300_19829295_ChIP-Seq_ESCs_Human2.08260848
13FUS_26573619_Chip-Seq_HEK293_Human2.06751248
14TAF15_26573619_Chip-Seq_HEK293_Human2.02114536
15EWS_26573619_Chip-Seq_HEK293_Human2.00572468
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97019717
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.89906810
18ER_23166858_ChIP-Seq_MCF-7_Human1.83255571
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.75937769
20CBP_20019798_ChIP-Seq_JUKART_Human1.70662867
21IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70662867
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69871978
23SMAD4_21799915_ChIP-Seq_A2780_Human1.69538005
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67174325
25STAT3_23295773_ChIP-Seq_U87_Human1.66848510
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.65771150
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64898755
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64869224
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64733257
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62641267
31BCAT_22108803_ChIP-Seq_LS180_Human1.61086104
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60596322
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60596322
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57995857
35AR_25329375_ChIP-Seq_VCAP_Human1.56899688
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56543460
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53794726
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53121472
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51997351
40TCF4_23295773_ChIP-Seq_U87_Human1.51644460
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50213259
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45833803
43IRF1_19129219_ChIP-ChIP_H3396_Human1.45735896
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44962426
45REST_21632747_ChIP-Seq_MESCs_Mouse1.44887314
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.44387246
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44073282
48TP53_22573176_ChIP-Seq_HFKS_Human1.40802602
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39970366
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38670007
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.36836887
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35465761
53RNF2_27304074_Chip-Seq_NSC_Mouse1.33798785
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33794701
55* RUNX2_22187159_ChIP-Seq_PCA_Human1.33779137
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33260919
57TCF4_22108803_ChIP-Seq_LS180_Human1.32656024
58* NANOG_19829295_ChIP-Seq_ESCs_Human1.28092191
59* SOX2_19829295_ChIP-Seq_ESCs_Human1.28092191
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25133108
61SMAD4_21741376_ChIP-Seq_EPCs_Human1.24994437
62AR_21572438_ChIP-Seq_LNCaP_Human1.20372789
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19653783
64DROSHA_22980978_ChIP-Seq_HELA_Human1.19202597
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18060606
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16894834
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.16708076
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16708076
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16119060
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15991150
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.15438094
72* GATA3_21878914_ChIP-Seq_MCF-7_Human1.14017954
73MYC_18940864_ChIP-ChIP_HL60_Human1.12745571
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.12193965
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11759165
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10801932
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.09946060
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09273106
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.09146955
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.08774555
81NCOR_22424771_ChIP-Seq_293T_Human1.06845313
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.05425911
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04931183
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04822622
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04434756
86AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03710948
87HOXB7_26014856_ChIP-Seq_BT474_Human1.03443338
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01672781
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99355950
90AR_20517297_ChIP-Seq_VCAP_Human0.99289855
91CDX2_22108803_ChIP-Seq_LS180_Human0.99090355
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98351952
93REST_18959480_ChIP-ChIP_MESCs_Mouse0.96790538
94SOX2_21211035_ChIP-Seq_LN229_Gbm0.96015250
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94934485
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.94555188
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.93473967
98* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93205915
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.92996704
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.92515747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.88697761
2MP0002102_abnormal_ear_morphology2.55523393
3MP0005551_abnormal_eye_electrophysiolog2.53805348
4MP0003195_calcinosis2.51168735
5MP0001968_abnormal_touch/_nociception2.37177358
6MP0001984_abnormal_olfaction2.28229982
7MP0000569_abnormal_digit_pigmentation2.23397725
8MP0002653_abnormal_ependyma_morphology2.19292486
9MP0006072_abnormal_retinal_apoptosis2.19017510
10MP0002736_abnormal_nociception_after2.09241404
11MP0005253_abnormal_eye_physiology2.02696733
12MP0003136_yellow_coat_color2.00009506
13MP0009046_muscle_twitch1.99950605
14MP0009745_abnormal_behavioral_response1.96545447
15MP0003787_abnormal_imprinting1.93475467
16MP0000372_irregular_coat_pigmentation1.91670689
17MP0006292_abnormal_olfactory_placode1.87600464
18MP0002638_abnormal_pupillary_reflex1.84391433
19MP0003880_abnormal_central_pattern1.81184371
20MP0008872_abnormal_physiological_respon1.80630538
21MP0006276_abnormal_autonomic_nervous1.80210107
22MP0001501_abnormal_sleep_pattern1.79588820
23MP0001485_abnormal_pinna_reflex1.78557706
24MP0004142_abnormal_muscle_tone1.76871321
25MP0005645_abnormal_hypothalamus_physiol1.76708205
26MP0003646_muscle_fatigue1.74845273
27MP0005410_abnormal_fertilization1.73030575
28MP0002272_abnormal_nervous_system1.71234161
29MP0004133_heterotaxia1.69515071
30MP0001486_abnormal_startle_reflex1.66874451
31MP0002837_dystrophic_cardiac_calcinosis1.63857348
32MP0001986_abnormal_taste_sensitivity1.55997937
33MP0001529_abnormal_vocalization1.55370753
34MP0003878_abnormal_ear_physiology1.53633863
35MP0005377_hearing/vestibular/ear_phenot1.53633863
36MP0002928_abnormal_bile_duct1.50807308
37MP0003718_maternal_effect1.50418087
38MP0002938_white_spotting1.49767278
39MP0008875_abnormal_xenobiotic_pharmacok1.48918071
40MP0005646_abnormal_pituitary_gland1.46884336
41MP0002572_abnormal_emotion/affect_behav1.45992634
42MP0002876_abnormal_thyroid_physiology1.43159372
43MP0002557_abnormal_social/conspecific_i1.42654788
44MP0004885_abnormal_endolymph1.42475289
45MP0002735_abnormal_chemical_nociception1.42445688
46MP0002064_seizures1.39159961
47MP0000427_abnormal_hair_cycle1.39032529
48MP0004043_abnormal_pH_regulation1.36801129
49MP0001970_abnormal_pain_threshold1.35972589
50MP0000631_abnormal_neuroendocrine_gland1.32855232
51MP0004147_increased_porphyrin_level1.31381021
52MP0008789_abnormal_olfactory_epithelium1.30842734
53MP0004742_abnormal_vestibular_system1.30171014
54MP0002733_abnormal_thermal_nociception1.27823897
55MP0002822_catalepsy1.25299203
56MP0002067_abnormal_sensory_capabilities1.24662364
57MP0001905_abnormal_dopamine_level1.24305228
58MP0003698_abnormal_male_reproductive1.22770702
59MP0004924_abnormal_behavior1.22303553
60MP0005386_behavior/neurological_phenoty1.22303553
61MP0003011_delayed_dark_adaptation1.19684551
62MP0000778_abnormal_nervous_system1.19547768
63MP0003635_abnormal_synaptic_transmissio1.18968918
64MP0001929_abnormal_gametogenesis1.18769977
65MP0003122_maternal_imprinting1.18408603
66MP0005084_abnormal_gallbladder_morpholo1.17693629
67MP0002734_abnormal_mechanical_nocicepti1.14708347
68MP0005167_abnormal_blood-brain_barrier1.13708563
69MP0003121_genomic_imprinting1.12284084
70MP0004145_abnormal_muscle_electrophysio1.12087745
71MP0005195_abnormal_posterior_eye1.09327857
72MP0005394_taste/olfaction_phenotype1.08502883
73MP0005499_abnormal_olfactory_system1.08502883
74MP0010386_abnormal_urinary_bladder1.08025730
75MP0001963_abnormal_hearing_physiology1.07851431
76MP0005174_abnormal_tail_pigmentation1.06388059
77MP0002063_abnormal_learning/memory/cond1.05316329
78MP0002752_abnormal_somatic_nervous1.05251021
79MP0000026_abnormal_inner_ear1.00093857
80MP0002163_abnormal_gland_morphology0.99829489
81MP0002229_neurodegeneration0.99159592
82MP0002160_abnormal_reproductive_system0.98652131
83MP0005389_reproductive_system_phenotype0.98158470
84MP0002234_abnormal_pharynx_morphology0.96577318
85MP0001324_abnormal_eye_pigmentation0.93164432
86MP0002210_abnormal_sex_determination0.92791170
87MP0002184_abnormal_innervation0.91128495
88MP0003119_abnormal_digestive_system0.90882071
89MP0004215_abnormal_myocardial_fiber0.88866173
90MP0001440_abnormal_grooming_behavior0.88382900
91MP0005391_vision/eye_phenotype0.86592875
92MP0005075_abnormal_melanosome_morpholog0.85771246
93MP0002909_abnormal_adrenal_gland0.84201500
94MP0000653_abnormal_sex_gland0.83833045
95MP0000230_abnormal_systemic_arterial0.83310424
96MP0000955_abnormal_spinal_cord0.81091213
97MP0005379_endocrine/exocrine_gland_phen0.80185058
98MP0002277_abnormal_respiratory_mucosa0.79095562
99MP0002882_abnormal_neuron_morphology0.78945215
100MP0002751_abnormal_autonomic_nervous0.78529765

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.50147151
2Pancreatic fibrosis (HP:0100732)4.15244830
3True hermaphroditism (HP:0010459)4.09453774
4Abnormality of midbrain morphology (HP:0002418)3.98060546
5Molar tooth sign on MRI (HP:0002419)3.98060546
6Nephronophthisis (HP:0000090)3.74802715
7Congenital stationary night blindness (HP:0007642)3.69909775
8Medial flaring of the eyebrow (HP:0010747)3.52216904
9Abnormality of the renal medulla (HP:0100957)3.30281369
10Hyperventilation (HP:0002883)3.27952871
11Abnormality of the renal cortex (HP:0011035)3.15536938
12Attenuation of retinal blood vessels (HP:0007843)3.09412564
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.09182376
14Absent/shortened dynein arms (HP:0200106)3.09182376
15Chronic hepatic failure (HP:0100626)3.03709623
16Gait imbalance (HP:0002141)2.98383933
17Abnormal respiratory epithelium morphology (HP:0012253)2.97470059
18Abnormal respiratory motile cilium morphology (HP:0005938)2.97470059
19Cystic liver disease (HP:0006706)2.94206775
20Type II lissencephaly (HP:0007260)2.91710257
21Congenital primary aphakia (HP:0007707)2.90948531
22Abnormal ciliary motility (HP:0012262)2.87246948
23Progressive cerebellar ataxia (HP:0002073)2.77875764
24Abolished electroretinogram (ERG) (HP:0000550)2.73887744
25Polydipsia (HP:0001959)2.72653748
26Abnormal drinking behavior (HP:0030082)2.72653748
27Sclerocornea (HP:0000647)2.70241917
28Decreased central vision (HP:0007663)2.67134775
29Nephrogenic diabetes insipidus (HP:0009806)2.63977047
30Gaze-evoked nystagmus (HP:0000640)2.62165795
31Genetic anticipation (HP:0003743)2.60578653
32Genital tract atresia (HP:0001827)2.60177029
33Abnormal rod and cone electroretinograms (HP:0008323)2.57788257
34Vaginal atresia (HP:0000148)2.51479440
35Tubular atrophy (HP:0000092)2.46675053
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.46532572
37Abnormality of the labia minora (HP:0012880)2.43426056
38Abnormal respiratory motile cilium physiology (HP:0012261)2.42937771
39Anencephaly (HP:0002323)2.37564538
40Bile duct proliferation (HP:0001408)2.34597918
41Abnormal biliary tract physiology (HP:0012439)2.34597918
42Bony spicule pigmentary retinopathy (HP:0007737)2.32389564
43Congenital hepatic fibrosis (HP:0002612)2.27665105
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.25951494
45Postaxial foot polydactyly (HP:0001830)2.23431912
46Cerebellar dysplasia (HP:0007033)2.21152371
47Poor coordination (HP:0002370)2.18502192
48Retinal dysplasia (HP:0007973)2.16311659
49Polyuria (HP:0000103)2.16174803
50Renal cortical cysts (HP:0000803)2.15220497
51Lissencephaly (HP:0001339)2.14386330
52Pendular nystagmus (HP:0012043)2.12601077
53Inability to walk (HP:0002540)2.12549594
54Abnormality of macular pigmentation (HP:0008002)2.10052476
55Decreased circulating renin level (HP:0003351)2.09914466
56Broad-based gait (HP:0002136)2.08190089
57Postaxial hand polydactyly (HP:0001162)2.07623986
58Male pseudohermaphroditism (HP:0000037)2.07553356
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05893731
60Congenital sensorineural hearing impairment (HP:0008527)2.05643483
61Keratoconus (HP:0000563)2.04124498
62Increased corneal curvature (HP:0100692)2.04124498
63Furrowed tongue (HP:0000221)2.03646439
64Hypothermia (HP:0002045)2.02855062
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02510247
66Abnormality of alanine metabolism (HP:0010916)2.02510247
67Hyperalaninemia (HP:0003348)2.02510247
68Febrile seizures (HP:0002373)2.01838344
69Hemiparesis (HP:0001269)2.01835987
70Occipital encephalocele (HP:0002085)2.01172825
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98810585
72Large for gestational age (HP:0001520)1.97106539
73Intestinal atresia (HP:0011100)1.94525130
74Optic nerve hypoplasia (HP:0000609)1.94270357
75Progressive inability to walk (HP:0002505)1.93249143
76Rhinitis (HP:0012384)1.91637157
77Pachygyria (HP:0001302)1.86832998
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86245357
79Retinitis pigmentosa (HP:0000510)1.83944180
80Anophthalmia (HP:0000528)1.82916321
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82912853
82Preaxial hand polydactyly (HP:0001177)1.81833802
83Absent speech (HP:0001344)1.80890082
84Astigmatism (HP:0000483)1.75368875
85Tubulointerstitial nephritis (HP:0001970)1.74427484
86Stomach cancer (HP:0012126)1.74075659
87Increased CSF lactate (HP:0002490)1.74015438
88Abnormal urine output (HP:0012590)1.73181845
89Hypoplasia of the fovea (HP:0007750)1.71969466
90Aplasia/Hypoplasia of the fovea (HP:0008060)1.71969466
91Specific learning disability (HP:0001328)1.71319884
92Chorioretinal atrophy (HP:0000533)1.70788306
93Ketosis (HP:0001946)1.69839431
94Fair hair (HP:0002286)1.69165884
95Supernumerary spleens (HP:0009799)1.68152334
96Bilateral microphthalmos (HP:0007633)1.67932647
97Methylmalonic aciduria (HP:0012120)1.67576570
98Mitochondrial inheritance (HP:0001427)1.67124329
99Protruding tongue (HP:0010808)1.65992942
100Polyphagia (HP:0002591)1.65500944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.22224232
2ADRBK23.08892905
3BMPR1B2.96726466
4WNK32.95476570
5MAP4K22.74341756
6PINK12.64195624
7INSRR2.37488827
8ACVR1B2.32952904
9ZAK2.30740589
10NUAK12.30204752
11GRK12.23253535
12CASK2.14568424
13MAP3K41.99855691
14WNK41.91567396
15MAPK131.78927397
16TAOK31.71898715
17TRIM281.53195252
18STK391.52623576
19OXSR11.47214411
20MKNK21.41825990
21TLK11.40016494
22MAPK151.28633974
23TNIK1.24469998
24MAP2K71.21959989
25STK38L1.21851099
26DYRK21.18165185
27PNCK1.17189652
28TXK1.10776633
29BCR1.10242750
30PAK31.10218704
31ADRBK11.09672820
32PLK21.09163993
33NTRK31.06525184
34CSNK1G21.05888063
35PTK2B1.05184654
36PRKCE1.03527489
37PRKCG1.02637157
38DAPK21.02569991
39MARK10.99040263
40BRSK20.98423574
41BCKDK0.96197044
42CSNK1G30.95499693
43CSNK1A1L0.94930871
44TGFBR10.94742606
45CSNK1G10.93602132
46VRK10.87016446
47FGFR20.79737606
48PLK40.77618414
49CDK190.77011514
50MKNK10.76711149
51PLK30.75308207
52DYRK30.74294769
53TIE10.70046358
54PKN10.69473341
55CAMKK20.63606089
56MARK30.63085770
57MST40.61497855
58EPHA40.59615630
59SIK20.57509481
60CAMK2A0.57274923
61PRKCQ0.56607657
62NTRK20.56088555
63DYRK1A0.54413117
64PHKG20.52818036
65PHKG10.52818036
66VRK20.52315542
67FER0.50725046
68OBSCN0.49258997
69TAF10.48728843
70NME10.48402604
71CAMK10.47214095
72PRKACA0.44726141
73MUSK0.44526682
74RPS6KA50.43720832
75FLT30.43345636
76NEK20.43209129
77PRKCZ0.42782643
78KIT0.42070550
79PLK10.42043718
80ERBB30.41803219
81PRKAA10.41448446
82MAPKAPK30.40990300
83TEC0.40589593
84CSNK1A10.40370676
85WEE10.40265821
86STK30.40136870
87PIK3CA0.39802405
88EPHA30.38829371
89STK110.38768111
90PRKG10.38759449
91TNK20.38688302
92AKT30.38490056
93MAPKAPK50.37736529
94CSNK1D0.37305424
95PRKCI0.36353942
96PRKAA20.35873248
97EIF2AK30.35473852
98CDK30.34798894
99CHEK20.32987577
100GRK50.32843875

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.32438730
2Phototransduction_Homo sapiens_hsa047442.99167328
3Butanoate metabolism_Homo sapiens_hsa006502.92054469
4Linoleic acid metabolism_Homo sapiens_hsa005912.44105444
5Nicotine addiction_Homo sapiens_hsa050332.34074448
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25978974
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14638650
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.09939283
9Nitrogen metabolism_Homo sapiens_hsa009102.09730016
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04544294
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03336763
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92716737
13Protein export_Homo sapiens_hsa030601.87229020
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.85432181
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84308786
16Tryptophan metabolism_Homo sapiens_hsa003801.77759141
17Propanoate metabolism_Homo sapiens_hsa006401.72326324
18Selenocompound metabolism_Homo sapiens_hsa004501.70486579
19Taste transduction_Homo sapiens_hsa047421.69944323
20Homologous recombination_Homo sapiens_hsa034401.69839205
21Olfactory transduction_Homo sapiens_hsa047401.67023843
22Oxidative phosphorylation_Homo sapiens_hsa001901.65619433
23Ether lipid metabolism_Homo sapiens_hsa005651.63305769
24Caffeine metabolism_Homo sapiens_hsa002321.57313653
25Fanconi anemia pathway_Homo sapiens_hsa034601.56368120
26Basal transcription factors_Homo sapiens_hsa030221.55393770
27Morphine addiction_Homo sapiens_hsa050321.50930070
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45393477
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44306953
30GABAergic synapse_Homo sapiens_hsa047271.37679021
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.37002022
32RNA polymerase_Homo sapiens_hsa030201.33094166
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32131502
34Chemical carcinogenesis_Homo sapiens_hsa052041.30060860
35Parkinsons disease_Homo sapiens_hsa050121.28044732
36ABC transporters_Homo sapiens_hsa020101.25582770
37Circadian entrainment_Homo sapiens_hsa047131.24231378
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.20673240
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18922039
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15939748
41Retinol metabolism_Homo sapiens_hsa008301.14032336
42Serotonergic synapse_Homo sapiens_hsa047261.12979704
43Huntingtons disease_Homo sapiens_hsa050161.12206380
44Glutamatergic synapse_Homo sapiens_hsa047241.11623441
45beta-Alanine metabolism_Homo sapiens_hsa004101.10013395
46Peroxisome_Homo sapiens_hsa041461.09916793
47RNA degradation_Homo sapiens_hsa030181.09668604
48Insulin secretion_Homo sapiens_hsa049111.08763476
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05885829
50Regulation of autophagy_Homo sapiens_hsa041401.05030568
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02542969
52Arachidonic acid metabolism_Homo sapiens_hsa005901.01471469
53Histidine metabolism_Homo sapiens_hsa003400.90440098
54Salivary secretion_Homo sapiens_hsa049700.86238339
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86191021
56Steroid biosynthesis_Homo sapiens_hsa001000.83504801
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83482424
58Cardiac muscle contraction_Homo sapiens_hsa042600.82692406
59Ovarian steroidogenesis_Homo sapiens_hsa049130.82396067
60Glycerolipid metabolism_Homo sapiens_hsa005610.82041661
61Calcium signaling pathway_Homo sapiens_hsa040200.76414173
62Purine metabolism_Homo sapiens_hsa002300.73749006
63Fat digestion and absorption_Homo sapiens_hsa049750.73208275
64Alzheimers disease_Homo sapiens_hsa050100.72982981
65Non-homologous end-joining_Homo sapiens_hsa034500.68591704
66Fatty acid degradation_Homo sapiens_hsa000710.68084062
67One carbon pool by folate_Homo sapiens_hsa006700.65489910
68Metabolic pathways_Homo sapiens_hsa011000.65200287
69Collecting duct acid secretion_Homo sapiens_hsa049660.63347980
70Dorso-ventral axis formation_Homo sapiens_hsa043200.63296374
71Circadian rhythm_Homo sapiens_hsa047100.63249591
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62209201
73Dopaminergic synapse_Homo sapiens_hsa047280.62066154
74Hedgehog signaling pathway_Homo sapiens_hsa043400.60606732
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56719696
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.56364993
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56307380
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.54545495
79Fatty acid metabolism_Homo sapiens_hsa012120.52659206
80Cocaine addiction_Homo sapiens_hsa050300.51106250
81Lysine degradation_Homo sapiens_hsa003100.50093802
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47924277
83Arginine and proline metabolism_Homo sapiens_hsa003300.47496230
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46831418
85Cholinergic synapse_Homo sapiens_hsa047250.44492223
86Oxytocin signaling pathway_Homo sapiens_hsa049210.41885260
87cAMP signaling pathway_Homo sapiens_hsa040240.41480796
88Sulfur relay system_Homo sapiens_hsa041220.41420653
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41345349
90Fatty acid biosynthesis_Homo sapiens_hsa000610.40519614
91Fatty acid elongation_Homo sapiens_hsa000620.39315605
92Long-term depression_Homo sapiens_hsa047300.38640410
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.38354879
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.36711755
95Mineral absorption_Homo sapiens_hsa049780.35580396
96Amphetamine addiction_Homo sapiens_hsa050310.34915064
97Sphingolipid metabolism_Homo sapiens_hsa006000.33789166
98Gastric acid secretion_Homo sapiens_hsa049710.30992989
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30782146
100Glutathione metabolism_Homo sapiens_hsa004800.28916177

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