ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.07725337
2	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	4.95304469
3	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	4.95304469
4	positive regulation of CREB transcription factor activity (GO:0032793)	4.83432482
5	rRNA methylation (GO:0031167)	4.73912095
6	cobalamin metabolic process (GO:0009235)	4.71786336
7	ncRNA 3-end processing (GO:0043628)	4.44502323
8	rRNA modification (GO:0000154)	4.25768494
9	centriole replication (GO:0007099)	4.10345631
10	regulation of Golgi to plasma membrane protein transport (GO:0042996)	4.04169687
11	replicative senescence (GO:0090399)	3.95285421
12	lateral ventricle development (GO:0021670)	3.86974739
13	establishment of mitochondrion localization (GO:0051654)	3.79289509
14	nonmotile primary cilium assembly (GO:0035058)	3.67701589
15	neurofilament cytoskeleton organization (GO:0060052)	3.61960172
16	mitochondrion transport along microtubule (GO:0047497)	3.60973996
17	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.60973996
18	post-embryonic morphogenesis (GO:0009886)	3.52873854
19	seminiferous tubule development (GO:0072520)	3.47769197
20	regulation of plasminogen activation (GO:0010755)	3.44952463
21	positive regulation of vasculogenesis (GO:2001214)	3.43462169
22	ribonucleoprotein complex disassembly (GO:0032988)	3.40644018
23	regulation of coenzyme metabolic process (GO:0051196)	3.35548941
24	regulation of cofactor metabolic process (GO:0051193)	3.35548941
25	response to misfolded protein (GO:0051788)	3.34232359
26	retinal cone cell development (GO:0046549)	3.33580994
27	microtubule nucleation (GO:0007020)	3.26871974
28	mannosylation (GO:0097502)	3.21607680
29	protein localization to synapse (GO:0035418)	3.21070021
30	negative regulation of neurotransmitter secretion (GO:0046929)	3.21055271
31	pyrimidine dimer repair (GO:0006290)	3.16571828
32	retinal rod cell development (GO:0046548)	3.16329250
33	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.09525625
34	myeloid cell homeostasis (GO:0002262)	3.07813709
35	reciprocal meiotic recombination (GO:0007131)	3.06813959
36	reciprocal DNA recombination (GO:0035825)	3.06813959
37	forebrain morphogenesis (GO:0048853)	3.04069877
38	protein targeting to Golgi (GO:0000042)	2.99604093
39	preassembly of GPI anchor in ER membrane (GO:0016254)	2.99031375
40	establishment of protein localization to Golgi (GO:0072600)	2.95628988
41	dosage compensation (GO:0007549)	2.94440086
42	snRNA processing (GO:0016180)	2.92547055
43	homocysteine metabolic process (GO:0050667)	2.92345832
44	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.90719845
45	microtubule severing (GO:0051013)	2.86096102
46	anterograde synaptic vesicle transport (GO:0048490)	2.84895197
47	ATP synthesis coupled proton transport (GO:0015986)	2.83191656
48	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.83191656
49	maturation of SSU-rRNA (GO:0030490)	2.81541249
50	cilium or flagellum-dependent cell motility (GO:0001539)	2.80200270
51	translational termination (GO:0006415)	2.79902239
52	regulation of telomere maintenance (GO:0032204)	2.78607294
53	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.78548996
54	detection of light stimulus involved in sensory perception (GO:0050962)	2.76975476
55	detection of light stimulus involved in visual perception (GO:0050908)	2.76975476
56	regulation of centriole replication (GO:0046599)	2.75949542
57	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.74968928
58	head development (GO:0060322)	2.74758383
59	viral transcription (GO:0019083)	2.73703113
60	telomere maintenance via telomerase (GO:0007004)	2.73180343
61	photoreceptor cell development (GO:0042461)	2.72603067
62	positive regulation of mitochondrial membrane permeability (GO:0035794)	2.70812094
63	protein autoprocessing (GO:0016540)	2.70245230
64	regulation of helicase activity (GO:0051095)	2.69823125
65	regulation of relaxation of muscle (GO:1901077)	2.69153705
66	piRNA metabolic process (GO:0034587)	2.68990987
67	eye photoreceptor cell development (GO:0042462)	2.68341126
68	relaxation of smooth muscle (GO:0044557)	2.67929435
69	spermatid nucleus differentiation (GO:0007289)	2.67847192
70	regulation of G0 to G1 transition (GO:0070316)	2.64220185
71	cardiac epithelial to mesenchymal transition (GO:0060317)	2.63102680
72	protein import into peroxisome matrix (GO:0016558)	2.62524467
73	centriole assembly (GO:0098534)	2.61829343
74	regulation of cilium movement (GO:0003352)	2.61262725
75	regulation of collateral sprouting (GO:0048670)	2.59848340
76	DNA double-strand break processing (GO:0000729)	2.58716461
77	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.58016356
78	superoxide anion generation (GO:0042554)	2.57821035
79	folic acid metabolic process (GO:0046655)	2.56787295
80	snRNA metabolic process (GO:0016073)	2.54804365
81	protein localization to Golgi apparatus (GO:0034067)	2.54035060
82	DNA methylation involved in gamete generation (GO:0043046)	2.53057996
83	rRNA catabolic process (GO:0016075)	2.52979160
84	microtubule polymerization or depolymerization (GO:0031109)	2.52641242
85	histone H2A acetylation (GO:0043968)	2.52342087
86	photoreceptor cell maintenance (GO:0045494)	2.52315091
87	natural killer cell differentiation (GO:0001779)	2.50657014
88	negative regulation of neurotransmitter transport (GO:0051589)	2.49853436
89	ubiquinone biosynthetic process (GO:0006744)	2.48582020
90	nerve growth factor signaling pathway (GO:0038180)	2.48284403
91	positive regulation of granulocyte differentiation (GO:0030854)	2.48072281
92	somite development (GO:0061053)	2.47918777
93	peroxisome fission (GO:0016559)	2.46805089
94	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.45915020
95	spliceosomal complex assembly (GO:0000245)	2.45536656
96	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.45035342
97	DNA topological change (GO:0006265)	2.43292289
98	dendritic spine morphogenesis (GO:0060997)	2.42129792
99	regulation of Rac protein signal transduction (GO:0035020)	2.42119422
100	DNA integration (GO:0015074)	2.41168948

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_19390658_ChIP-ChIP_HaCaT_Human	3.53811367
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.28741130
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.16019826
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.13791984
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.13061281
6	E2F7_22180533_ChIP-Seq_HELA_Human	3.04632821
7	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	2.99179042
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97190501
9	EWS_26573619_Chip-Seq_HEK293_Human	2.84017647
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.81240849
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.61934346
12	FUS_26573619_Chip-Seq_HEK293_Human	2.57784669
13	IRF1_19129219_ChIP-ChIP_H3396_Human	2.57667768
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.49216613
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.42666214
16	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.38857749
17	CIITA_25753668_ChIP-Seq_RAJI_Human	2.12857989
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.11282181
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.06804283
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.06213403
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.98318917
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.95544922
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.94905707
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.93756923
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.93506672
26	TTF2_22483619_ChIP-Seq_HELA_Human	1.78776108
27	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.77598343
28	VDR_22108803_ChIP-Seq_LS180_Human	1.76850727
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.74662477
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71519603
31	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.68639769
32	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.68578483
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.68476030
34	XRN2_22483619_ChIP-Seq_HELA_Human	1.65486935
35	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.64223171
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.64207893
37	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.63325595
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.56466326
39	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49046710
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.48244060
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46258409
42	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.43377937
43	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.42002971
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.41889955
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41889955
46	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.39694885
47	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.38489343
48	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.38316833
49	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.35752065
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.34918962
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.33758350
52	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.33301097
53	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.33266325
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32538940
55	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.31389441
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.28366153
57	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.25524288
58	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.25109455
59	GABP_19822575_ChIP-Seq_HepG2_Human	1.23797429
60	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.22540829
61	P300_19829295_ChIP-Seq_ESCs_Human	1.19469872
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16323887
63	DCP1A_22483619_ChIP-Seq_HELA_Human	1.15970478
64	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.15744784
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14468150
66	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.14413799
67	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.14119957
68	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.11599314
69	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.11599233
70	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.10670767
71	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.08409316
72	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07090953
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04516669
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04516669
75	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.03507343
76	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.03061596
77	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.02748609
78	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.00427194
79	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.00182602
80	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99084479
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98223141
82	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.97987447
83	STAT3_23295773_ChIP-Seq_U87_Human	0.96347271
84	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.95027399
85	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.93878140
86	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.93629731
87	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.93620912
88	AR_20517297_ChIP-Seq_VCAP_Human	0.92548808
89	MYC_18940864_ChIP-ChIP_HL60_Human	0.92046486
90	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.91967399
91	NCOR_22424771_ChIP-Seq_293T_Human	0.91749207
92	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.91571774
93	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.91045610
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.89952577
95	KDM5A_27292631_Chip-Seq_BREAST_Human	0.89430536
96	TCF4_23295773_ChIP-Seq_U87_Human	0.89396220
97	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.88335548
98	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.87517620
99	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.85370113
100	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.85144070

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001348_abnormal_lacrimal_gland	4.97758267
2	MP0008877_abnormal_DNA_methylation	3.94168633
3	MP0008058_abnormal_DNA_repair	2.52368954
4	MP0001299_abnormal_eye_distance/	2.48004978
5	MP0002396_abnormal_hematopoietic_system	2.34108183
6	MP0004145_abnormal_muscle_electrophysio	2.33008621
7	MP0005645_abnormal_hypothalamus_physiol	2.27531690
8	MP0001984_abnormal_olfaction	2.27458040
9	MP0001529_abnormal_vocalization	2.22262939
10	MP0005083_abnormal_biliary_tract	2.10437823
11	MP0006292_abnormal_olfactory_placode	2.09142378
12	MP0005253_abnormal_eye_physiology	2.06833267
13	MP0003656_abnormal_erythrocyte_physiolo	2.00286602
14	MP0008789_abnormal_olfactory_epithelium	1.95149035
15	MP0002876_abnormal_thyroid_physiology	1.93684499
16	MP0003787_abnormal_imprinting	1.91266048
17	MP0008995_early_reproductive_senescence	1.90465574
18	MP0005499_abnormal_olfactory_system	1.78640679
19	MP0005394_taste/olfaction_phenotype	1.78640679
20	MP0003786_premature_aging	1.75449552
21	MP0006072_abnormal_retinal_apoptosis	1.74003366
22	MP0005551_abnormal_eye_electrophysiolog	1.73899588
23	MP0006276_abnormal_autonomic_nervous	1.69323004
24	MP0005084_abnormal_gallbladder_morpholo	1.61715656
25	MP0003567_abnormal_fetal_cardiomyocyte	1.58819161
26	MP0010094_abnormal_chromosome_stability	1.55428056
27	MP0005410_abnormal_fertilization	1.50192931
28	MP0000566_synostosis	1.48215289
29	MP0004742_abnormal_vestibular_system	1.46717022
30	MP0003890_abnormal_embryonic-extraembry	1.44240222
31	MP0009379_abnormal_foot_pigmentation	1.43034369
32	MP0009046_muscle_twitch	1.41258872
33	MP0002751_abnormal_autonomic_nervous	1.39839056
34	MP0003221_abnormal_cardiomyocyte_apopto	1.36864175
35	MP0001145_abnormal_male_reproductive	1.35551931
36	MP0000631_abnormal_neuroendocrine_gland	1.32373140
37	MP0001929_abnormal_gametogenesis	1.30841000
38	MP0002210_abnormal_sex_determination	1.30670586
39	MP0003698_abnormal_male_reproductive	1.30002208
40	MP0000049_abnormal_middle_ear	1.28420603
41	MP0003121_genomic_imprinting	1.27309476
42	MP0001661_extended_life_span	1.26969501
43	MP0000653_abnormal_sex_gland	1.24626133
44	MP0000778_abnormal_nervous_system	1.24369867
45	MP0003077_abnormal_cell_cycle	1.22425227
46	MP0006035_abnormal_mitochondrial_morpho	1.20882415
47	MP0003111_abnormal_nucleus_morphology	1.20837937
48	MP0005391_vision/eye_phenotype	1.20226738
49	MP0003183_abnormal_peptide_metabolism	1.19313239
50	MP0002102_abnormal_ear_morphology	1.18348033
51	MP0008057_abnormal_DNA_replication	1.15344337
52	MP0003011_delayed_dark_adaptation	1.09791999
53	MP0002160_abnormal_reproductive_system	1.04342609
54	MP0000955_abnormal_spinal_cord	1.01342649
55	MP0002067_abnormal_sensory_capabilities	0.99690224
56	MP0004957_abnormal_blastocyst_morpholog	0.98593305
57	MP0002928_abnormal_bile_duct	0.98233361
58	MP0003186_abnormal_redox_activity	0.96217747
59	MP0004197_abnormal_fetal_growth/weight/	0.96110490
60	MP0003122_maternal_imprinting	0.95868282
61	MP0003172_abnormal_lysosome_physiology	0.95373134
62	MP0005195_abnormal_posterior_eye	0.93930050
63	MP0008775_abnormal_heart_ventricle	0.93727932
64	MP0002234_abnormal_pharynx_morphology	0.93627404
65	MP0001486_abnormal_startle_reflex	0.92960018
66	MP0002882_abnormal_neuron_morphology	0.92378821
67	MP0003693_abnormal_embryo_hatching	0.91849109
68	MP0003123_paternal_imprinting	0.91301654
69	MP0002557_abnormal_social/conspecific_i	0.90379004
70	MP0002752_abnormal_somatic_nervous	0.90299525
71	MP0003635_abnormal_synaptic_transmissio	0.89960142
72	MP0001963_abnormal_hearing_physiology	0.87963464
73	MP0001485_abnormal_pinna_reflex	0.87320906
74	MP0002653_abnormal_ependyma_morphology	0.87313597
75	MP0001293_anophthalmia	0.86742649
76	MP0010386_abnormal_urinary_bladder	0.86571996
77	MP0004084_abnormal_cardiac_muscle	0.86487801
78	MP0000639_abnormal_adrenal_gland	0.85535122
79	MP0003880_abnormal_central_pattern	0.82687940
80	MP0004142_abnormal_muscle_tone	0.81718199
81	MP0002161_abnormal_fertility/fecundity	0.81529946
82	MP0002229_neurodegeneration	0.81108034
83	MP0002092_abnormal_eye_morphology	0.80496617
84	MP0003755_abnormal_palate_morphology	0.80394156
85	MP0002909_abnormal_adrenal_gland	0.79661005
86	MP0005085_abnormal_gallbladder_physiolo	0.78812566
87	MP0006036_abnormal_mitochondrial_physio	0.76965692
88	MP0003315_abnormal_perineum_morphology	0.76053348
89	MP0002184_abnormal_innervation	0.75451656
90	MP0003935_abnormal_craniofacial_develop	0.74835761
91	MP0003195_calcinosis	0.72270904
92	MP0008932_abnormal_embryonic_tissue	0.72087548
93	MP0003861_abnormal_nervous_system	0.72033726
94	MP0009384_cardiac_valve_regurgitation	0.71286854
95	MP0004811_abnormal_neuron_physiology	0.70559517
96	MP0001502_abnormal_circadian_rhythm	0.69613033
97	MP0008872_abnormal_physiological_respon	0.69090875
98	MP0005397_hematopoietic_system_phenotyp	0.69024351
99	MP0001545_abnormal_hematopoietic_system	0.69024351
100	MP0003937_abnormal_limbs/digits/tail_de	0.66989460

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	4.50083236
2	Abnormal number of erythroid precursors (HP:0012131)	4.18526841
3	Tubulointerstitial nephritis (HP:0001970)	4.01626690
4	Chromsome breakage (HP:0040012)	3.91997519
5	Abnormality of homocysteine metabolism (HP:0010919)	3.44789618
6	Homocystinuria (HP:0002156)	3.44789618
7	Medial flaring of the eyebrow (HP:0010747)	3.35814717
8	Facial hemangioma (HP:0000329)	3.09331673
9	Prolonged partial thromboplastin time (HP:0003645)	3.01481368
10	Chronic hepatic failure (HP:0100626)	2.97982618
11	Gastrointestinal stroma tumor (HP:0100723)	2.94797904
12	Supernumerary spleens (HP:0009799)	2.93296660
13	Methylmalonic acidemia (HP:0002912)	2.89432913
14	Gait imbalance (HP:0002141)	2.88253532
15	Pancreatic fibrosis (HP:0100732)	2.87147747
16	Congenital primary aphakia (HP:0007707)	2.85790544
17	Nephrogenic diabetes insipidus (HP:0009806)	2.77900139
18	Hyperglycinemia (HP:0002154)	2.69737418
19	Oligodactyly (hands) (HP:0001180)	2.66951606
20	Gonadotropin excess (HP:0000837)	2.58492846
21	Abnormality of the intrinsic pathway (HP:0010989)	2.56263267
22	Reticulocytopenia (HP:0001896)	2.53808361
23	Bile duct proliferation (HP:0001408)	2.52969889
24	Abnormal biliary tract physiology (HP:0012439)	2.52969889
25	Aplastic anemia (HP:0001915)	2.44773720
26	11 pairs of ribs (HP:0000878)	2.40900907
27	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.38448019
28	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.38448019
29	Dyschromatopsia (HP:0007641)	2.36960128
30	Broad-based gait (HP:0002136)	2.33028516
31	Abnormal pancreas size (HP:0012094)	2.32729424
32	Capillary hemangiomas (HP:0005306)	2.30739911
33	Nephronophthisis (HP:0000090)	2.25959524
34	Cortical visual impairment (HP:0100704)	2.25740858
35	Progressive external ophthalmoplegia (HP:0000590)	2.24500090
36	Abnormality of the renal cortex (HP:0011035)	2.21141316
37	Facial cleft (HP:0002006)	2.20053302
38	Congenital stationary night blindness (HP:0007642)	2.17111911
39	Recurrent sinusitis (HP:0011108)	2.16938340
40	Septo-optic dysplasia (HP:0100842)	2.16074168
41	Abnormality of midbrain morphology (HP:0002418)	2.15171970
42	Molar tooth sign on MRI (HP:0002419)	2.15171970
43	Pancreatic cysts (HP:0001737)	2.14598921
44	Sensory axonal neuropathy (HP:0003390)	2.14009273
45	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.11738642
46	Renal cortical cysts (HP:0000803)	2.11594972
47	Status epilepticus (HP:0002133)	2.11410163
48	True hermaphroditism (HP:0010459)	2.08819280
49	Microvesicular hepatic steatosis (HP:0001414)	2.06230467
50	Sclerocornea (HP:0000647)	2.05949899
51	Abnormality of chromosome stability (HP:0003220)	2.05372358
52	Abnormality of methionine metabolism (HP:0010901)	2.05333484
53	Hip dysplasia (HP:0001385)	2.05257784
54	Small hand (HP:0200055)	2.05020584
55	3-Methylglutaconic aciduria (HP:0003535)	2.04466561
56	Macrocytic anemia (HP:0001972)	2.02367459
57	Pallor (HP:0000980)	2.00013384
58	Attenuation of retinal blood vessels (HP:0007843)	1.97395573
59	Abnormality of the renal medulla (HP:0100957)	1.96129446
60	Poor coordination (HP:0002370)	1.94616344
61	Bony spicule pigmentary retinopathy (HP:0007737)	1.93494803
62	Hepatocellular necrosis (HP:0001404)	1.93185853
63	Tubular atrophy (HP:0000092)	1.92832772
64	Epileptic encephalopathy (HP:0200134)	1.92624589
65	Vaginal atresia (HP:0000148)	1.92262051
66	Abnormal protein glycosylation (HP:0012346)	1.90822516
67	Abnormal glycosylation (HP:0012345)	1.90822516
68	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.90822516
69	Abnormal protein N-linked glycosylation (HP:0012347)	1.90822516
70	Ectopic kidney (HP:0000086)	1.89881149
71	Abnormality of reticulocytes (HP:0004312)	1.87845052
72	Myokymia (HP:0002411)	1.87519074
73	Volvulus (HP:0002580)	1.85650231
74	Anophthalmia (HP:0000528)	1.84526642
75	Reduced antithrombin III activity (HP:0001976)	1.83478993
76	Acute myeloid leukemia (HP:0004808)	1.81089041
77	Type II lissencephaly (HP:0007260)	1.80525884
78	Genital tract atresia (HP:0001827)	1.80467945
79	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.78657166
80	Protruding tongue (HP:0010808)	1.77924433
81	Abnormal lung lobation (HP:0002101)	1.77414347
82	Double outlet right ventricle (HP:0001719)	1.76565698
83	Congenital malformation of the right heart (HP:0011723)	1.76565698
84	Abnormality of glycine metabolism (HP:0010895)	1.76557991
85	Abnormality of serine family amino acid metabolism (HP:0010894)	1.76557991
86	Increased serum lactate (HP:0002151)	1.75917410
87	Atonic seizures (HP:0010819)	1.74283595
88	Hepatic necrosis (HP:0002605)	1.72506617
89	Renovascular hypertension (HP:0100817)	1.71147878
90	Postaxial foot polydactyly (HP:0001830)	1.68570582
91	Lymphopenia (HP:0001888)	1.68305379
92	Methylmalonic aciduria (HP:0012120)	1.68211958
93	Optic nerve hypoplasia (HP:0000609)	1.67230980
94	Increased purine levels (HP:0004368)	1.65357278
95	Hyperuricemia (HP:0002149)	1.65357278
96	Limb hypertonia (HP:0002509)	1.65285674
97	Oligodactyly (HP:0012165)	1.65254880
98	Retinitis pigmentosa (HP:0000510)	1.65081245
99	Increased serum pyruvate (HP:0003542)	1.63247531
100	Asplenia (HP:0001746)	1.63128064

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	4.12600942
2	MAP4K2	4.09296099
3	PLK4	3.04168974
4	BRSK2	2.87349074
5	BCR	2.64498325
6	CASK	2.31366491
7	PDK2	2.29067871
8	BRD4	2.25241796
9	OBSCN	2.23982913
10	TRIM28	2.16240043
11	TTK	1.98914112
12	WNK4	1.86740801
13	CLK1	1.84444358
14	CAMKK2	1.81111700
15	EIF2AK3	1.80647902
16	PIK3CG	1.77047101
17	BCKDK	1.74179456
18	NEK9	1.72687984
19	SRPK1	1.67940216
20	CDK8	1.67736090
21	BRSK1	1.59859393
22	BMPR2	1.57190574
23	ZAK	1.51911601
24	MAP3K4	1.43353989
25	STK39	1.26180517
26	PAK3	1.20503294
27	CDC7	1.18598386
28	ATR	1.10426049
29	BUB1	1.06703257
30	BTK	1.04834226
31	MAP3K6	1.04379873
32	ERBB3	1.03371821
33	ICK	1.02978744
34	PLK2	1.02021534
35	CSNK1G2	1.00650484
36	INSRR	1.00410499
37	DYRK3	0.99424739
38	MARK1	0.96241978
39	PRPF4B	0.95940241
40	NEK2	0.92753412
41	EPHB2	0.92253808
42	NUAK1	0.92007138
43	RPS6KA4	0.89329801
44	PIK3CA	0.89139279
45	KSR1	0.87288949
46	ADRBK2	0.84736146
47	BMPR1B	0.84412723
48	WNK1	0.80824334
49	RAF1	0.80544308
50	NEK1	0.79447351
51	CDK3	0.79080977
52	DYRK2	0.78356509
53	MAPK13	0.77530806
54	TYRO3	0.75953525
55	WEE1	0.73629876
56	CSNK1E	0.73115987
57	CHEK1	0.71662417
58	FLT3	0.71465532
59	CHEK2	0.70459140
60	EIF2AK1	0.68867526
61	CAMK1D	0.68862157
62	STK11	0.67925083
63	CAMK1	0.67787752
64	STK38	0.67197759
65	DMPK	0.66948754
66	SIK3	0.65782654
67	PIM2	0.64953261
68	MARK2	0.64562250
69	ATM	0.64208437
70	CDK9	0.62466347
71	PRKCI	0.61745559
72	RPS6KA5	0.61222725
73	MAP3K5	0.60069850
74	LIMK1	0.59433945
75	PBK	0.58853983
76	PRKAA1	0.57903724
77	MINK1	0.55545754
78	CSNK2A2	0.55102298
79	SGK1	0.51789669
80	LRRK2	0.51544327
81	PLK1	0.51507079
82	AURKB	0.50973598
83	DYRK1A	0.50095134
84	CDK2	0.49882106
85	CAMK4	0.49677043
86	PRKCQ	0.49411646
87	PKN2	0.48549357
88	RPS6KB1	0.47858568
89	CAMK1G	0.47478266
90	PNCK	0.46881879
91	STK38L	0.46399017
92	MARK3	0.45846442
93	CSNK1G3	0.45725232
94	RPS6KB2	0.45082191
95	MAP2K7	0.44973526
96	STK3	0.42948963
97	NTRK3	0.42297102
98	CAMKK1	0.41665351
99	RPS6KA3	0.40600300
100	MAPK9	0.39889044

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.55200732
2	Homologous recombination_Homo sapiens_hsa03440	3.45507557
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.12080363
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.85919039
5	Protein export_Homo sapiens_hsa03060	2.85157710
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.63991507
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.51643770
8	Mismatch repair_Homo sapiens_hsa03430	2.46695539
9	One carbon pool by folate_Homo sapiens_hsa00670	2.40537631
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.40411672
11	Ribosome_Homo sapiens_hsa03010	2.33214595
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.15506589
13	RNA degradation_Homo sapiens_hsa03018	2.15489925
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.14889563
15	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.09853355
16	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.95890579
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.93136869
18	Butanoate metabolism_Homo sapiens_hsa00650	1.89863490
19	RNA transport_Homo sapiens_hsa03013	1.87248748
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.78389737
21	Basal transcription factors_Homo sapiens_hsa03022	1.68476402
22	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.52812183
23	Parkinsons disease_Homo sapiens_hsa05012	1.52592877
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.51025947
25	DNA replication_Homo sapiens_hsa03030	1.49791417
26	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.41625478
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.40273118
28	Huntingtons disease_Homo sapiens_hsa05016	1.40128492
29	RNA polymerase_Homo sapiens_hsa03020	1.35667876
30	mRNA surveillance pathway_Homo sapiens_hsa03015	1.31531459
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.29418999
32	Phototransduction_Homo sapiens_hsa04744	1.28190169
33	Fatty acid elongation_Homo sapiens_hsa00062	1.22352101
34	Alzheimers disease_Homo sapiens_hsa05010	1.15363140
35	Lysine degradation_Homo sapiens_hsa00310	1.14372216
36	Oocyte meiosis_Homo sapiens_hsa04114	1.13036648
37	Olfactory transduction_Homo sapiens_hsa04740	1.12159144
38	GABAergic synapse_Homo sapiens_hsa04727	1.09411586
39	Nicotine addiction_Homo sapiens_hsa05033	1.09147524
40	Cell cycle_Homo sapiens_hsa04110	1.08346119
41	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.04146032
42	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.02769445
43	Spliceosome_Homo sapiens_hsa03040	1.01160008
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.01123154
45	Propanoate metabolism_Homo sapiens_hsa00640	1.00548061
46	Regulation of autophagy_Homo sapiens_hsa04140	0.98868239
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.90439479
48	Morphine addiction_Homo sapiens_hsa05032	0.84472973
49	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.83825280
50	Pancreatic secretion_Homo sapiens_hsa04972	0.80036834
51	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.77272859
52	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.75041151
53	Glutamatergic synapse_Homo sapiens_hsa04724	0.74892281
54	Peroxisome_Homo sapiens_hsa04146	0.73077263
55	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.72283980
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.71083862
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.70505168
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.67915534
59	Caffeine metabolism_Homo sapiens_hsa00232	0.66960021
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.65282838
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65257225
62	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.65084935
63	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63569769
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.62933470
65	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.62448395
66	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62263435
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.62212507
68	Taste transduction_Homo sapiens_hsa04742	0.61454878
69	Amphetamine addiction_Homo sapiens_hsa05031	0.60679930
70	Metabolic pathways_Homo sapiens_hsa01100	0.59943936
71	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.59394463
72	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.55859347
73	Base excision repair_Homo sapiens_hsa03410	0.55409937
74	Primary immunodeficiency_Homo sapiens_hsa05340	0.51588370
75	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.51403244
76	Axon guidance_Homo sapiens_hsa04360	0.50556806
77	Glucagon signaling pathway_Homo sapiens_hsa04922	0.48374164
78	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.47962211
79	Purine metabolism_Homo sapiens_hsa00230	0.47060108
80	Circadian entrainment_Homo sapiens_hsa04713	0.44097822
81	Insulin secretion_Homo sapiens_hsa04911	0.43412459
82	Protein digestion and absorption_Homo sapiens_hsa04974	0.43400855
83	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.43366658
84	Basal cell carcinoma_Homo sapiens_hsa05217	0.42626975
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42447472
86	Dopaminergic synapse_Homo sapiens_hsa04728	0.40684813
87	Cocaine addiction_Homo sapiens_hsa05030	0.39814264
88	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.38474762
89	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.37770869
90	Circadian rhythm_Homo sapiens_hsa04710	0.37595454
91	Ether lipid metabolism_Homo sapiens_hsa00565	0.37040399
92	Salivary secretion_Homo sapiens_hsa04970	0.36882190
93	Alcoholism_Homo sapiens_hsa05034	0.35829490
94	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.34301125
95	ABC transporters_Homo sapiens_hsa02010	0.33282169
96	Carbon metabolism_Homo sapiens_hsa01200	0.33083477
97	Long-term potentiation_Homo sapiens_hsa04720	0.32170239
98	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.31393214
99	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.28210262
100	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.26847440

ZNF192P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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