Rank | Gene Set | Z-score |
---|---|---|
1 | DNA double-strand break processing (GO:0000729) | 4.69264511 |
2 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.09481883 |
3 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.96067492 |
4 | replication fork processing (GO:0031297) | 3.81055062 |
5 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.57694659 |
6 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.57694659 |
7 | chromatin remodeling at centromere (GO:0031055) | 3.53958480 |
8 | nucleobase catabolic process (GO:0046113) | 3.47181220 |
9 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.43299903 |
10 | presynaptic membrane assembly (GO:0097105) | 3.40308005 |
11 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.35924687 |
12 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.35924687 |
13 | DNA damage response, detection of DNA damage (GO:0042769) | 3.34011498 |
14 | CENP-A containing nucleosome assembly (GO:0034080) | 3.30148229 |
15 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.23457710 |
16 | negative regulation of DNA recombination (GO:0045910) | 3.21425905 |
17 | presynaptic membrane organization (GO:0097090) | 3.16850298 |
18 | DNA replication checkpoint (GO:0000076) | 3.14529513 |
19 | regulation of helicase activity (GO:0051095) | 3.13490465 |
20 | respiratory chain complex IV assembly (GO:0008535) | 3.07390510 |
21 | mitotic sister chromatid cohesion (GO:0007064) | 3.05578172 |
22 | histone exchange (GO:0043486) | 3.03198088 |
23 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.00905606 |
24 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 3.00150483 |
25 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 3.00150483 |
26 | regulation of translation, ncRNA-mediated (GO:0045974) | 3.00150483 |
27 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.99545008 |
28 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.94867371 |
29 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.94867371 |
30 | regulation of centriole replication (GO:0046599) | 2.94632805 |
31 | postreplication repair (GO:0006301) | 2.91349879 |
32 | protein neddylation (GO:0045116) | 2.87121737 |
33 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.86310692 |
34 | peptidyl-histidine modification (GO:0018202) | 2.85357729 |
35 | telomere maintenance via telomerase (GO:0007004) | 2.85342764 |
36 | proteasome assembly (GO:0043248) | 2.84496511 |
37 | kinetochore assembly (GO:0051382) | 2.83183060 |
38 | neural tube formation (GO:0001841) | 2.82626363 |
39 | regulation of telomere maintenance (GO:0032204) | 2.81366143 |
40 | DNA replication-independent nucleosome organization (GO:0034724) | 2.78787086 |
41 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.78787086 |
42 | regulation of DNA endoreduplication (GO:0032875) | 2.76740016 |
43 | kinetochore organization (GO:0051383) | 2.76513852 |
44 | resolution of meiotic recombination intermediates (GO:0000712) | 2.75985652 |
45 | protein-cofactor linkage (GO:0018065) | 2.74735663 |
46 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.74632475 |
47 | histone H2A acetylation (GO:0043968) | 2.72153631 |
48 | non-recombinational repair (GO:0000726) | 2.69378798 |
49 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.69378798 |
50 | protein complex biogenesis (GO:0070271) | 2.65973852 |
51 | regulation of alternative mRNA splicing, via spliceosome (GO:0000381) | 2.65153741 |
52 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.63810404 |
53 | olfactory bulb development (GO:0021772) | 2.63444035 |
54 | behavioral response to nicotine (GO:0035095) | 2.62769239 |
55 | cullin deneddylation (GO:0010388) | 2.62431593 |
56 | recombinational repair (GO:0000725) | 2.62310595 |
57 | cytochrome complex assembly (GO:0017004) | 2.62100102 |
58 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.62073447 |
59 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.62073447 |
60 | NADH dehydrogenase complex assembly (GO:0010257) | 2.62073447 |
61 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.61525931 |
62 | double-strand break repair via homologous recombination (GO:0000724) | 2.58461566 |
63 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.56788499 |
64 | purine nucleobase biosynthetic process (GO:0009113) | 2.54420640 |
65 | pseudouridine synthesis (GO:0001522) | 2.53971271 |
66 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.53850949 |
67 | nucleobase biosynthetic process (GO:0046112) | 2.53709061 |
68 | spindle checkpoint (GO:0031577) | 2.53070100 |
69 | microtubule depolymerization (GO:0007019) | 2.51193436 |
70 | chaperone-mediated protein transport (GO:0072321) | 2.48804588 |
71 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.48793254 |
72 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.48793254 |
73 | nonmotile primary cilium assembly (GO:0035058) | 2.48286650 |
74 | mitotic spindle checkpoint (GO:0071174) | 2.48170161 |
75 | kidney morphogenesis (GO:0060993) | 2.47963980 |
76 | intraciliary transport (GO:0042073) | 2.46155629 |
77 | L-serine metabolic process (GO:0006563) | 2.46132484 |
78 | histone mRNA metabolic process (GO:0008334) | 2.46030163 |
79 | microtubule anchoring (GO:0034453) | 2.45827201 |
80 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.45740757 |
81 | synapsis (GO:0007129) | 2.44695355 |
82 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.43914842 |
83 | termination of RNA polymerase III transcription (GO:0006386) | 2.43914842 |
84 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.43823074 |
85 | negative regulation of sister chromatid segregation (GO:0033046) | 2.43823074 |
86 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.43823074 |
87 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.43823074 |
88 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.43823074 |
89 | negative regulation of telomere maintenance (GO:0032205) | 2.43316011 |
90 | retinal cone cell development (GO:0046549) | 2.43270761 |
91 | mitochondrial RNA metabolic process (GO:0000959) | 2.43265797 |
92 | centriole replication (GO:0007099) | 2.42178222 |
93 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.40974858 |
94 | isotype switching (GO:0045190) | 2.40974858 |
95 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.40974858 |
96 | IMP biosynthetic process (GO:0006188) | 2.40851017 |
97 | atrial cardiac muscle cell action potential (GO:0086014) | 2.39774898 |
98 | neuron cell-cell adhesion (GO:0007158) | 2.39414036 |
99 | maturation of 5.8S rRNA (GO:0000460) | 2.38127074 |
100 | ubiquinone metabolic process (GO:0006743) | 2.37633007 |
Rank | Gene Set | Z-score |
---|---|---|
1 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 3.32387558 |
2 | * ZNF274_21170338_ChIP-Seq_K562_Hela | 3.28597490 |
3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.27472065 |
4 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.94397346 |
5 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.70180857 |
6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.68138579 |
7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.62330565 |
8 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.60649751 |
9 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.52554543 |
10 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.49588787 |
11 | FUS_26573619_Chip-Seq_HEK293_Human | 2.48972723 |
12 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.43928722 |
13 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.40281822 |
14 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.35810189 |
15 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.34093216 |
16 | EWS_26573619_Chip-Seq_HEK293_Human | 2.30781070 |
17 | VDR_22108803_ChIP-Seq_LS180_Human | 2.27681670 |
18 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.27353972 |
19 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.21902899 |
20 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.08853082 |
21 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.02752219 |
22 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.01220409 |
23 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.92511578 |
24 | P300_19829295_ChIP-Seq_ESCs_Human | 1.91213498 |
25 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.83223337 |
26 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.79785036 |
27 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.77308129 |
28 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.76031051 |
29 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.75400120 |
30 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.69949530 |
31 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.68136850 |
32 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.67036284 |
33 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.66659887 |
34 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.62755118 |
35 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.60748156 |
36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.60394593 |
37 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.55941225 |
38 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.55105091 |
39 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.54760785 |
40 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.50458932 |
41 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.47393360 |
42 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.42227688 |
43 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.42108140 |
44 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.41549071 |
45 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.37403241 |
46 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.36511158 |
47 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.34513001 |
48 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.33705814 |
49 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.33642419 |
50 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.32292500 |
51 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.30076147 |
52 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.30020995 |
53 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.29907078 |
54 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.29799929 |
55 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.29344884 |
56 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.28475466 |
57 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.28272275 |
58 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.27444600 |
59 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.26802833 |
60 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.20615839 |
61 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.20608052 |
62 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.20100770 |
63 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.19977754 |
64 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.19842808 |
65 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.18582623 |
66 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.18523804 |
67 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.18523804 |
68 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.17554557 |
69 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.17554557 |
70 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.16516451 |
71 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.15214149 |
72 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.14414296 |
73 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.12837832 |
74 | * KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.12318958 |
75 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.11680260 |
76 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.10622847 |
77 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.09922758 |
78 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.08392084 |
79 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.06507090 |
80 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.06254806 |
81 | STAT3_23295773_ChIP-Seq_U87_Human | 1.06182123 |
82 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.05859438 |
83 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.05562331 |
84 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.05025971 |
85 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.04156284 |
86 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.03490254 |
87 | TCF4_23295773_ChIP-Seq_U87_Human | 1.01052040 |
88 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.01017481 |
89 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.00140872 |
90 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.99438204 |
91 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.98885124 |
92 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.98334776 |
93 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.98237374 |
94 | AR_25329375_ChIP-Seq_VCAP_Human | 0.98096323 |
95 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.97512951 |
96 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.97455454 |
97 | * GABP_19822575_ChIP-Seq_HepG2_Human | 0.96862847 |
98 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.96290249 |
99 | JUN_21703547_ChIP-Seq_K562_Human | 0.96251786 |
100 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.94671699 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0008877_abnormal_DNA_methylation | 3.13020871 |
2 | MP0008058_abnormal_DNA_repair | 2.91668224 |
3 | MP0003787_abnormal_imprinting | 2.78424424 |
4 | MP0006292_abnormal_olfactory_placode | 2.57974852 |
5 | MP0002102_abnormal_ear_morphology | 2.49224090 |
6 | MP0010094_abnormal_chromosome_stability | 2.45086249 |
7 | MP0008057_abnormal_DNA_replication | 2.43987949 |
8 | MP0003880_abnormal_central_pattern | 2.36820544 |
9 | MP0001529_abnormal_vocalization | 2.29323815 |
10 | MP0003121_genomic_imprinting | 2.24528307 |
11 | MP0003890_abnormal_embryonic-extraembry | 2.24201301 |
12 | MP0003693_abnormal_embryo_hatching | 2.01209811 |
13 | MP0003122_maternal_imprinting | 1.98797444 |
14 | MP0008789_abnormal_olfactory_epithelium | 1.96696339 |
15 | MP0006072_abnormal_retinal_apoptosis | 1.87383432 |
16 | MP0003718_maternal_effect | 1.84392974 |
17 | MP0002751_abnormal_autonomic_nervous | 1.75920801 |
18 | MP0004133_heterotaxia | 1.74534908 |
19 | MP0005394_taste/olfaction_phenotype | 1.73597824 |
20 | MP0005499_abnormal_olfactory_system | 1.73597824 |
21 | MP0001188_hyperpigmentation | 1.72470172 |
22 | MP0006276_abnormal_autonomic_nervous | 1.66284041 |
23 | MP0002736_abnormal_nociception_after | 1.65246544 |
24 | MP0003567_abnormal_fetal_cardiomyocyte | 1.65108704 |
25 | MP0001984_abnormal_olfaction | 1.65082959 |
26 | MP0000778_abnormal_nervous_system | 1.64933129 |
27 | MP0004957_abnormal_blastocyst_morpholog | 1.64066889 |
28 | MP0002938_white_spotting | 1.63943080 |
29 | MP0003111_abnormal_nucleus_morphology | 1.62279892 |
30 | MP0001293_anophthalmia | 1.55117394 |
31 | MP0000372_irregular_coat_pigmentation | 1.53788390 |
32 | MP0009697_abnormal_copulation | 1.51107522 |
33 | MP0005551_abnormal_eye_electrophysiolog | 1.48057792 |
34 | MP0005253_abnormal_eye_physiology | 1.46732817 |
35 | MP0003119_abnormal_digestive_system | 1.46580652 |
36 | MP0001968_abnormal_touch/_nociception | 1.46254061 |
37 | MP0009046_muscle_twitch | 1.46078224 |
38 | MP0003937_abnormal_limbs/digits/tail_de | 1.42515154 |
39 | MP0003077_abnormal_cell_cycle | 1.39128572 |
40 | MP0008932_abnormal_embryonic_tissue | 1.38535891 |
41 | MP0005645_abnormal_hypothalamus_physiol | 1.37362396 |
42 | MP0008995_early_reproductive_senescence | 1.36503716 |
43 | MP0000631_abnormal_neuroendocrine_gland | 1.33248929 |
44 | MP0002234_abnormal_pharynx_morphology | 1.28284895 |
45 | MP0003136_yellow_coat_color | 1.27373517 |
46 | MP0001486_abnormal_startle_reflex | 1.27072896 |
47 | MP0002233_abnormal_nose_morphology | 1.25226128 |
48 | MP0000049_abnormal_middle_ear | 1.19491063 |
49 | MP0000647_abnormal_sebaceous_gland | 1.15272677 |
50 | MP0003195_calcinosis | 1.14918701 |
51 | MP0002272_abnormal_nervous_system | 1.12705362 |
52 | MP0002557_abnormal_social/conspecific_i | 1.12481227 |
53 | MP0002184_abnormal_innervation | 1.12346879 |
54 | MP0008007_abnormal_cellular_replicative | 1.11391600 |
55 | MP0004043_abnormal_pH_regulation | 1.07625744 |
56 | MP0009745_abnormal_behavioral_response | 1.07492353 |
57 | MP0001286_abnormal_eye_development | 1.06531675 |
58 | MP0002653_abnormal_ependyma_morphology | 1.05341406 |
59 | MP0001485_abnormal_pinna_reflex | 1.04272278 |
60 | MP0003861_abnormal_nervous_system | 1.04197456 |
61 | MP0002837_dystrophic_cardiac_calcinosis | 1.02992602 |
62 | MP0005423_abnormal_somatic_nervous | 1.02668926 |
63 | MP0004270_analgesia | 1.01665690 |
64 | MP0003941_abnormal_skin_development | 1.01338460 |
65 | MP0002210_abnormal_sex_determination | 1.00318787 |
66 | MP0003635_abnormal_synaptic_transmissio | 0.99290994 |
67 | MP0003786_premature_aging | 0.97296478 |
68 | MP0001929_abnormal_gametogenesis | 0.96992567 |
69 | MP0002752_abnormal_somatic_nervous | 0.96832433 |
70 | MP0003755_abnormal_palate_morphology | 0.96577637 |
71 | MP0002572_abnormal_emotion/affect_behav | 0.96270193 |
72 | MP0005187_abnormal_penis_morphology | 0.95181355 |
73 | MP0005367_renal/urinary_system_phenotyp | 0.95017029 |
74 | MP0000516_abnormal_urinary_system | 0.95017029 |
75 | MP0009703_decreased_birth_body | 0.94715933 |
76 | MP0005084_abnormal_gallbladder_morpholo | 0.93698960 |
77 | MP0005386_behavior/neurological_phenoty | 0.92398675 |
78 | MP0004924_abnormal_behavior | 0.92398675 |
79 | MP0003123_paternal_imprinting | 0.92219304 |
80 | MP0002822_catalepsy | 0.92209286 |
81 | MP0000955_abnormal_spinal_cord | 0.92156387 |
82 | MP0003698_abnormal_male_reproductive | 0.88578137 |
83 | MP0006035_abnormal_mitochondrial_morpho | 0.87735039 |
84 | MP0004885_abnormal_endolymph | 0.87204361 |
85 | MP0005391_vision/eye_phenotype | 0.86746665 |
86 | MP0001145_abnormal_male_reproductive | 0.86704241 |
87 | MP0000653_abnormal_sex_gland | 0.86614298 |
88 | MP0002638_abnormal_pupillary_reflex | 0.86553878 |
89 | MP0004142_abnormal_muscle_tone | 0.86413335 |
90 | MP0002734_abnormal_mechanical_nocicepti | 0.86062919 |
91 | MP0002063_abnormal_learning/memory/cond | 0.85090094 |
92 | MP0004215_abnormal_myocardial_fiber | 0.84691627 |
93 | MP0001177_atelectasis | 0.84122929 |
94 | MP0002067_abnormal_sensory_capabilities | 0.84082179 |
95 | MP0004811_abnormal_neuron_physiology | 0.83704554 |
96 | MP0002084_abnormal_developmental_patter | 0.79409126 |
97 | MP0009672_abnormal_birth_weight | 0.79262466 |
98 | MP0002882_abnormal_neuron_morphology | 0.79118165 |
99 | MP0002152_abnormal_brain_morphology | 0.78949143 |
100 | MP0005195_abnormal_posterior_eye | 0.78257359 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of the labia minora (HP:0012880) | 3.91423280 |
2 | Colon cancer (HP:0003003) | 3.23757453 |
3 | Methylmalonic acidemia (HP:0002912) | 2.88318755 |
4 | Pancreatic cysts (HP:0001737) | 2.82965131 |
5 | Pancreatic fibrosis (HP:0100732) | 2.78750136 |
6 | Hyperglycinemia (HP:0002154) | 2.71042787 |
7 | Intestinal atresia (HP:0011100) | 2.69652782 |
8 | Abnormality of midbrain morphology (HP:0002418) | 2.67917499 |
9 | Molar tooth sign on MRI (HP:0002419) | 2.67917499 |
10 | Nephronophthisis (HP:0000090) | 2.65630426 |
11 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.64781604 |
12 | Medial flaring of the eyebrow (HP:0010747) | 2.64644534 |
13 | Volvulus (HP:0002580) | 2.60928404 |
14 | Meckel diverticulum (HP:0002245) | 2.57582733 |
15 | Abnormality of chromosome stability (HP:0003220) | 2.56106994 |
16 | Abnormality of the ileum (HP:0001549) | 2.52585268 |
17 | True hermaphroditism (HP:0010459) | 2.51364818 |
18 | Ependymoma (HP:0002888) | 2.42375793 |
19 | Gait imbalance (HP:0002141) | 2.39155918 |
20 | Methylmalonic aciduria (HP:0012120) | 2.35372453 |
21 | Congenital primary aphakia (HP:0007707) | 2.32538397 |
22 | Abnormality of the renal medulla (HP:0100957) | 2.28166731 |
23 | Nephrogenic diabetes insipidus (HP:0009806) | 2.23755132 |
24 | Increased hepatocellular lipid droplets (HP:0006565) | 2.23654211 |
25 | Genital tract atresia (HP:0001827) | 2.21739449 |
26 | Acute necrotizing encephalopathy (HP:0006965) | 2.18983092 |
27 | Acute encephalopathy (HP:0006846) | 2.18693047 |
28 | Lissencephaly (HP:0001339) | 2.16933777 |
29 | Pendular nystagmus (HP:0012043) | 2.16162185 |
30 | Neoplasm of the adrenal cortex (HP:0100641) | 2.12469120 |
31 | Vaginal atresia (HP:0000148) | 2.12309392 |
32 | Renal cortical cysts (HP:0000803) | 2.10755817 |
33 | Abnormality of the renal cortex (HP:0011035) | 2.09499951 |
34 | Birth length less than 3rd percentile (HP:0003561) | 2.09137078 |
35 | Broad-based gait (HP:0002136) | 2.07498385 |
36 | Chronic hepatic failure (HP:0100626) | 2.05374778 |
37 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.03981370 |
38 | Chromsome breakage (HP:0040012) | 2.03623986 |
39 | Abnormal lung lobation (HP:0002101) | 2.02408825 |
40 | Supernumerary spleens (HP:0009799) | 2.02339838 |
41 | Abnormality of the preputium (HP:0100587) | 2.00619106 |
42 | Glioma (HP:0009733) | 2.00406377 |
43 | Progressive macrocephaly (HP:0004481) | 1.99234005 |
44 | Abolished electroretinogram (ERG) (HP:0000550) | 1.98950447 |
45 | Hyperventilation (HP:0002883) | 1.98745989 |
46 | Lipid accumulation in hepatocytes (HP:0006561) | 1.97309343 |
47 | Abnormality of serum amino acid levels (HP:0003112) | 1.96866173 |
48 | Increased CSF lactate (HP:0002490) | 1.95072292 |
49 | Drooling (HP:0002307) | 1.94495106 |
50 | Abnormality of the astrocytes (HP:0100707) | 1.93666779 |
51 | Astrocytoma (HP:0009592) | 1.93666779 |
52 | Sloping forehead (HP:0000340) | 1.93459341 |
53 | Abnormality of glycine metabolism (HP:0010895) | 1.91845660 |
54 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.91845660 |
55 | Hepatoblastoma (HP:0002884) | 1.87959815 |
56 | Progressive inability to walk (HP:0002505) | 1.87706984 |
57 | Optic nerve hypoplasia (HP:0000609) | 1.87578024 |
58 | Bifid tongue (HP:0010297) | 1.87050337 |
59 | Hypothermia (HP:0002045) | 1.84272667 |
60 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.83328510 |
61 | Sclerocornea (HP:0000647) | 1.83148804 |
62 | Oligodactyly (hands) (HP:0001180) | 1.83052432 |
63 | Abnormality of the duodenum (HP:0002246) | 1.82694304 |
64 | Abnormality of vitamin B metabolism (HP:0004340) | 1.82420509 |
65 | Hyperglycinuria (HP:0003108) | 1.82261314 |
66 | Mitochondrial inheritance (HP:0001427) | 1.81367139 |
67 | Septo-optic dysplasia (HP:0100842) | 1.80973872 |
68 | Patellar aplasia (HP:0006443) | 1.80507462 |
69 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.80031447 |
70 | Dandy-Walker malformation (HP:0001305) | 1.80008411 |
71 | Duodenal stenosis (HP:0100867) | 1.78527075 |
72 | Small intestinal stenosis (HP:0012848) | 1.78527075 |
73 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.77396332 |
74 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.76813611 |
75 | Hypoplasia of the pons (HP:0012110) | 1.76241199 |
76 | Neoplasm of the adrenal gland (HP:0100631) | 1.75914119 |
77 | Gastrointestinal atresia (HP:0002589) | 1.75609588 |
78 | Abnormality of the pons (HP:0007361) | 1.74156692 |
79 | Poor coordination (HP:0002370) | 1.73670499 |
80 | Medulloblastoma (HP:0002885) | 1.73000933 |
81 | Astigmatism (HP:0000483) | 1.72915850 |
82 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.72644105 |
83 | Cortical dysplasia (HP:0002539) | 1.72591601 |
84 | Bile duct proliferation (HP:0001408) | 1.72444708 |
85 | Abnormal biliary tract physiology (HP:0012439) | 1.72444708 |
86 | Pachygyria (HP:0001302) | 1.72327847 |
87 | Small hand (HP:0200055) | 1.71896830 |
88 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.71733355 |
89 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.71342226 |
90 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.71152090 |
91 | Limb dystonia (HP:0002451) | 1.70785447 |
92 | Specific learning disability (HP:0001328) | 1.70232107 |
93 | Rhabdomyosarcoma (HP:0002859) | 1.70103041 |
94 | Anencephaly (HP:0002323) | 1.69571610 |
95 | Excessive salivation (HP:0003781) | 1.69502642 |
96 | Broad foot (HP:0001769) | 1.69320649 |
97 | Hyperalaninemia (HP:0003348) | 1.69022502 |
98 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.69022502 |
99 | Abnormality of alanine metabolism (HP:0010916) | 1.69022502 |
100 | Embryonal renal neoplasm (HP:0011794) | 1.68074051 |
Rank | Gene Set | Z-score |
---|---|---|
1 | WNK3 | 3.17633877 |
2 | CASK | 2.88742215 |
3 | FRK | 2.72877985 |
4 | MAP3K4 | 2.71855054 |
5 | MKNK2 | 2.63899203 |
6 | MARK1 | 2.52119005 |
7 | SRPK1 | 2.48938290 |
8 | ZAK | 2.45728873 |
9 | BMPR1B | 2.43332932 |
10 | TRIM28 | 2.40956227 |
11 | MAP4K2 | 2.39145858 |
12 | CDC7 | 2.17651254 |
13 | NUAK1 | 2.10618604 |
14 | MKNK1 | 2.09902421 |
15 | TSSK6 | 1.95142574 |
16 | TNIK | 1.93083487 |
17 | DYRK2 | 1.84672899 |
18 | MAPK13 | 1.84370045 |
19 | PLK3 | 1.84090682 |
20 | BCR | 1.83918984 |
21 | PLK4 | 1.81271329 |
22 | BUB1 | 1.80248455 |
23 | BRSK2 | 1.75480466 |
24 | TTK | 1.72773775 |
25 | MAP2K7 | 1.72422777 |
26 | EIF2AK3 | 1.63955551 |
27 | MST4 | 1.45625855 |
28 | WEE1 | 1.44848804 |
29 | ACVR1B | 1.36344947 |
30 | VRK1 | 1.36119337 |
31 | TAF1 | 1.28541547 |
32 | CSNK1G1 | 1.28298168 |
33 | NEK1 | 1.26824483 |
34 | CSNK1G2 | 1.23467350 |
35 | PNCK | 1.23407089 |
36 | ERBB3 | 1.18808313 |
37 | GRK1 | 1.16744751 |
38 | PLK1 | 1.15678356 |
39 | CSNK1G3 | 1.12591792 |
40 | DYRK3 | 1.07605596 |
41 | ADRBK2 | 1.05988392 |
42 | PLK2 | 0.98027508 |
43 | CSNK1A1L | 0.97502893 |
44 | PBK | 0.97340712 |
45 | VRK2 | 0.91572721 |
46 | OXSR1 | 0.91169982 |
47 | ATR | 0.89260592 |
48 | CHEK2 | 0.88662653 |
49 | BRD4 | 0.88369326 |
50 | PAK3 | 0.87795773 |
51 | WNK4 | 0.83543800 |
52 | STK16 | 0.80197160 |
53 | ATM | 0.79082635 |
54 | EPHA4 | 0.77706499 |
55 | TGFBR1 | 0.77139851 |
56 | NME1 | 0.76960760 |
57 | PRKCG | 0.74863308 |
58 | CDK19 | 0.74045583 |
59 | INSRR | 0.72837770 |
60 | STK39 | 0.71380197 |
61 | PRKCE | 0.68131658 |
62 | MAP2K4 | 0.63647974 |
63 | CDK3 | 0.63393734 |
64 | YES1 | 0.62526876 |
65 | MINK1 | 0.60806629 |
66 | STK38L | 0.60008923 |
67 | EIF2AK1 | 0.58317127 |
68 | PINK1 | 0.55544726 |
69 | RPS6KA4 | 0.54285355 |
70 | BRSK1 | 0.54247991 |
71 | CHEK1 | 0.53890130 |
72 | CSNK1E | 0.52638396 |
73 | STK3 | 0.52419916 |
74 | EIF2AK2 | 0.52067374 |
75 | FGFR2 | 0.50670102 |
76 | BCKDK | 0.50634287 |
77 | FGFR1 | 0.46534294 |
78 | DYRK1A | 0.45863898 |
79 | PRKDC | 0.43723985 |
80 | NTRK2 | 0.42523083 |
81 | CDK1 | 0.41255999 |
82 | DAPK2 | 0.40252554 |
83 | ERBB4 | 0.39858994 |
84 | AURKB | 0.39771933 |
85 | PASK | 0.39575576 |
86 | MAP3K12 | 0.39425676 |
87 | CSNK1D | 0.39374916 |
88 | AKT3 | 0.38569098 |
89 | CSNK1A1 | 0.37956550 |
90 | PKN1 | 0.37682105 |
91 | FLT3 | 0.37046704 |
92 | NTRK3 | 0.35733149 |
93 | NLK | 0.35513247 |
94 | TIE1 | 0.35330514 |
95 | CCNB1 | 0.34959012 |
96 | CSNK2A1 | 0.34065615 |
97 | CDK2 | 0.33084417 |
98 | CAMK2A | 0.32516610 |
99 | CSNK2A2 | 0.31861826 |
100 | NEK2 | 0.31791410 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Non-homologous end-joining_Homo sapiens_hsa03450 | 3.24684662 |
2 | Protein export_Homo sapiens_hsa03060 | 2.90932938 |
3 | RNA polymerase_Homo sapiens_hsa03020 | 2.60154009 |
4 | Basal transcription factors_Homo sapiens_hsa03022 | 2.57593360 |
5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.48286673 |
6 | Mismatch repair_Homo sapiens_hsa03430 | 2.48125215 |
7 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.46909769 |
8 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.45798210 |
9 | Homologous recombination_Homo sapiens_hsa03440 | 2.32729068 |
10 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.30288425 |
11 | Proteasome_Homo sapiens_hsa03050 | 2.19329006 |
12 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.12942530 |
13 | RNA degradation_Homo sapiens_hsa03018 | 2.05670668 |
14 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.01655466 |
15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.96831701 |
16 | RNA transport_Homo sapiens_hsa03013 | 1.95244109 |
17 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.94285767 |
18 | DNA replication_Homo sapiens_hsa03030 | 1.88347805 |
19 | Spliceosome_Homo sapiens_hsa03040 | 1.82587074 |
20 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.82508604 |
21 | Nicotine addiction_Homo sapiens_hsa05033 | 1.80782512 |
22 | Parkinsons disease_Homo sapiens_hsa05012 | 1.74655260 |
23 | Base excision repair_Homo sapiens_hsa03410 | 1.73900899 |
24 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.65619571 |
25 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.64978115 |
26 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.61214628 |
27 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.58391746 |
28 | Phototransduction_Homo sapiens_hsa04744 | 1.56832983 |
29 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.50357414 |
30 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.43182204 |
31 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.37664829 |
32 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.37311043 |
33 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.36016384 |
34 | Huntingtons disease_Homo sapiens_hsa05016 | 1.31597743 |
35 | Cell cycle_Homo sapiens_hsa04110 | 1.29703955 |
36 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.27442533 |
37 | Purine metabolism_Homo sapiens_hsa00230 | 1.17220385 |
38 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.16683808 |
39 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.13466107 |
40 | Taste transduction_Homo sapiens_hsa04742 | 1.11263673 |
41 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.10594634 |
42 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.09267480 |
43 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.05354663 |
44 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.02410190 |
45 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.99310567 |
46 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.97045472 |
47 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.95346379 |
48 | Alzheimers disease_Homo sapiens_hsa05010 | 0.94756986 |
49 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.91559528 |
50 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.87989081 |
51 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.87885047 |
52 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.83120456 |
53 | Peroxisome_Homo sapiens_hsa04146 | 0.82320638 |
54 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.77610980 |
55 | GABAergic synapse_Homo sapiens_hsa04727 | 0.76955509 |
56 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.73643281 |
57 | Ribosome_Homo sapiens_hsa03010 | 0.69561578 |
58 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.69214740 |
59 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.67667641 |
60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.67143373 |
61 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.65269375 |
62 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.65238436 |
63 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.64780121 |
64 | Olfactory transduction_Homo sapiens_hsa04740 | 0.62151727 |
65 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.61668443 |
66 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.59903132 |
67 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.57994083 |
68 | Morphine addiction_Homo sapiens_hsa05032 | 0.57826230 |
69 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.55644282 |
70 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.54933678 |
71 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.54447806 |
72 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.54319658 |
73 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.53546178 |
74 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.53411921 |
75 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.53088668 |
76 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.51361643 |
77 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.50028647 |
78 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.49783507 |
79 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.48940820 |
80 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.47610759 |
81 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.46810416 |
82 | Lysine degradation_Homo sapiens_hsa00310 | 0.44066078 |
83 | Retinol metabolism_Homo sapiens_hsa00830 | 0.43820470 |
84 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.42973200 |
85 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.40978526 |
86 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.40912933 |
87 | Alcoholism_Homo sapiens_hsa05034 | 0.40133449 |
88 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.39388510 |
89 | Axon guidance_Homo sapiens_hsa04360 | 0.39181859 |
90 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.37746384 |
91 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.37622711 |
92 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.37577620 |
93 | Circadian entrainment_Homo sapiens_hsa04713 | 0.37080282 |
94 | Carbon metabolism_Homo sapiens_hsa01200 | 0.35707884 |
95 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.35659280 |
96 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.34656326 |
97 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.34211853 |
98 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.33304063 |
99 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.33164294 |
100 | Cocaine addiction_Homo sapiens_hsa05030 | 0.33153666 |