ZNF195

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family. These family members are transcription factors that are implicated in a variety of cellular processes. This gene is located near the centromeric border of chromosome 11p15.5, next to an imprinted domain that is associated with maternal-specific loss of heterozygosity in Wilms' tumors. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.69264511
2pyrimidine nucleobase catabolic process (GO:0006208)4.09481883
3negative regulation of DNA-dependent DNA replication (GO:2000104)3.96067492
4replication fork processing (GO:0031297)3.81055062
5regulation of mitotic spindle checkpoint (GO:1903504)3.57694659
6regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.57694659
7chromatin remodeling at centromere (GO:0031055)3.53958480
8nucleobase catabolic process (GO:0046113)3.47181220
9regulation of nuclear cell cycle DNA replication (GO:0033262)3.43299903
10presynaptic membrane assembly (GO:0097105)3.40308005
11somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35924687
12somatic hypermutation of immunoglobulin genes (GO:0016446)3.35924687
13DNA damage response, detection of DNA damage (GO:0042769)3.34011498
14CENP-A containing nucleosome assembly (GO:0034080)3.30148229
15maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.23457710
16negative regulation of DNA recombination (GO:0045910)3.21425905
17presynaptic membrane organization (GO:0097090)3.16850298
18DNA replication checkpoint (GO:0000076)3.14529513
19regulation of helicase activity (GO:0051095)3.13490465
20respiratory chain complex IV assembly (GO:0008535)3.07390510
21mitotic sister chromatid cohesion (GO:0007064)3.05578172
22histone exchange (GO:0043486)3.03198088
23exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00905606
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00150483
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.00150483
26regulation of translation, ncRNA-mediated (GO:0045974)3.00150483
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99545008
28DNA replication-dependent nucleosome organization (GO:0034723)2.94867371
29DNA replication-dependent nucleosome assembly (GO:0006335)2.94867371
30regulation of centriole replication (GO:0046599)2.94632805
31postreplication repair (GO:0006301)2.91349879
32protein neddylation (GO:0045116)2.87121737
33DNA catabolic process, exonucleolytic (GO:0000738)2.86310692
34peptidyl-histidine modification (GO:0018202)2.85357729
35telomere maintenance via telomerase (GO:0007004)2.85342764
36proteasome assembly (GO:0043248)2.84496511
37kinetochore assembly (GO:0051382)2.83183060
38neural tube formation (GO:0001841)2.82626363
39regulation of telomere maintenance (GO:0032204)2.81366143
40DNA replication-independent nucleosome organization (GO:0034724)2.78787086
41DNA replication-independent nucleosome assembly (GO:0006336)2.78787086
42regulation of DNA endoreduplication (GO:0032875)2.76740016
43kinetochore organization (GO:0051383)2.76513852
44resolution of meiotic recombination intermediates (GO:0000712)2.75985652
45protein-cofactor linkage (GO:0018065)2.74735663
46water-soluble vitamin biosynthetic process (GO:0042364)2.74632475
47histone H2A acetylation (GO:0043968)2.72153631
48non-recombinational repair (GO:0000726)2.69378798
49double-strand break repair via nonhomologous end joining (GO:0006303)2.69378798
50protein complex biogenesis (GO:0070271)2.65973852
51regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.65153741
52RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63810404
53olfactory bulb development (GO:0021772)2.63444035
54behavioral response to nicotine (GO:0035095)2.62769239
55cullin deneddylation (GO:0010388)2.62431593
56recombinational repair (GO:0000725)2.62310595
57cytochrome complex assembly (GO:0017004)2.62100102
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62073447
59mitochondrial respiratory chain complex I assembly (GO:0032981)2.62073447
60NADH dehydrogenase complex assembly (GO:0010257)2.62073447
61mitochondrial respiratory chain complex assembly (GO:0033108)2.61525931
62double-strand break repair via homologous recombination (GO:0000724)2.58461566
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.56788499
64purine nucleobase biosynthetic process (GO:0009113)2.54420640
65pseudouridine synthesis (GO:0001522)2.53971271
66establishment of protein localization to mitochondrial membrane (GO:0090151)2.53850949
67nucleobase biosynthetic process (GO:0046112)2.53709061
68spindle checkpoint (GO:0031577)2.53070100
69microtubule depolymerization (GO:0007019)2.51193436
70chaperone-mediated protein transport (GO:0072321)2.48804588
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48793254
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48793254
73nonmotile primary cilium assembly (GO:0035058)2.48286650
74mitotic spindle checkpoint (GO:0071174)2.48170161
75kidney morphogenesis (GO:0060993)2.47963980
76intraciliary transport (GO:0042073)2.46155629
77L-serine metabolic process (GO:0006563)2.46132484
78histone mRNA metabolic process (GO:0008334)2.46030163
79microtubule anchoring (GO:0034453)2.45827201
80attachment of spindle microtubules to kinetochore (GO:0008608)2.45740757
81synapsis (GO:0007129)2.44695355
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.43914842
83termination of RNA polymerase III transcription (GO:0006386)2.43914842
84negative regulation of mitotic sister chromatid separation (GO:2000816)2.43823074
85negative regulation of sister chromatid segregation (GO:0033046)2.43823074
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.43823074
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.43823074
88negative regulation of mitotic sister chromatid segregation (GO:0033048)2.43823074
89negative regulation of telomere maintenance (GO:0032205)2.43316011
90retinal cone cell development (GO:0046549)2.43270761
91mitochondrial RNA metabolic process (GO:0000959)2.43265797
92centriole replication (GO:0007099)2.42178222
93somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.40974858
94isotype switching (GO:0045190)2.40974858
95somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.40974858
96IMP biosynthetic process (GO:0006188)2.40851017
97atrial cardiac muscle cell action potential (GO:0086014)2.39774898
98neuron cell-cell adhesion (GO:0007158)2.39414036
99maturation of 5.8S rRNA (GO:0000460)2.38127074
100ubiquinone metabolic process (GO:0006743)2.37633007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.32387558
2* ZNF274_21170338_ChIP-Seq_K562_Hela3.28597490
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27472065
4E2F7_22180533_ChIP-Seq_HELA_Human2.94397346
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70180857
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.68138579
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.62330565
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60649751
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52554543
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49588787
11FUS_26573619_Chip-Seq_HEK293_Human2.48972723
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43928722
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40281822
14IGF1R_20145208_ChIP-Seq_DFB_Human2.35810189
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34093216
16EWS_26573619_Chip-Seq_HEK293_Human2.30781070
17VDR_22108803_ChIP-Seq_LS180_Human2.27681670
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27353972
19ELK1_19687146_ChIP-ChIP_HELA_Human2.21902899
20GBX2_23144817_ChIP-Seq_PC3_Human2.08853082
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.02752219
22TAF15_26573619_Chip-Seq_HEK293_Human2.01220409
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92511578
24P300_19829295_ChIP-Seq_ESCs_Human1.91213498
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83223337
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79785036
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77308129
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76031051
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75400120
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69949530
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68136850
32VDR_23849224_ChIP-Seq_CD4+_Human1.67036284
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.66659887
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62755118
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60748156
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60394593
37MYC_18940864_ChIP-ChIP_HL60_Human1.55941225
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55105091
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54760785
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.50458932
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47393360
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42227688
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42108140
44SOX2_16153702_ChIP-ChIP_HESCs_Human1.41549071
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37403241
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.36511158
47FOXP3_21729870_ChIP-Seq_TREG_Human1.34513001
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33705814
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33642419
50EZH2_22144423_ChIP-Seq_EOC_Human1.32292500
51IRF1_19129219_ChIP-ChIP_H3396_Human1.30076147
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30020995
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29907078
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29799929
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29344884
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28475466
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28272275
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27444600
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26802833
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.20615839
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20608052
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.20100770
63SMAD4_21799915_ChIP-Seq_A2780_Human1.19977754
64ER_23166858_ChIP-Seq_MCF-7_Human1.19842808
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.18582623
66CBP_20019798_ChIP-Seq_JUKART_Human1.18523804
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18523804
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17554557
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17554557
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16516451
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15214149
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.14414296
73TP53_22573176_ChIP-Seq_HFKS_Human1.12837832
74* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12318958
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11680260
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.10622847
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09922758
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08392084
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06507090
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06254806
81STAT3_23295773_ChIP-Seq_U87_Human1.06182123
82RNF2_27304074_Chip-Seq_NSC_Mouse1.05859438
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.05562331
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05025971
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04156284
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.03490254
87TCF4_23295773_ChIP-Seq_U87_Human1.01052040
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01017481
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.00140872
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99438204
91TCF4_22108803_ChIP-Seq_LS180_Human0.98885124
92MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98334776
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98237374
94AR_25329375_ChIP-Seq_VCAP_Human0.98096323
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97512951
96RUNX2_22187159_ChIP-Seq_PCA_Human0.97455454
97* GABP_19822575_ChIP-Seq_HepG2_Human0.96862847
98TTF2_22483619_ChIP-Seq_HELA_Human0.96290249
99JUN_21703547_ChIP-Seq_K562_Human0.96251786
100BCAT_22108803_ChIP-Seq_LS180_Human0.94671699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.13020871
2MP0008058_abnormal_DNA_repair2.91668224
3MP0003787_abnormal_imprinting2.78424424
4MP0006292_abnormal_olfactory_placode2.57974852
5MP0002102_abnormal_ear_morphology2.49224090
6MP0010094_abnormal_chromosome_stability2.45086249
7MP0008057_abnormal_DNA_replication2.43987949
8MP0003880_abnormal_central_pattern2.36820544
9MP0001529_abnormal_vocalization2.29323815
10MP0003121_genomic_imprinting2.24528307
11MP0003890_abnormal_embryonic-extraembry2.24201301
12MP0003693_abnormal_embryo_hatching2.01209811
13MP0003122_maternal_imprinting1.98797444
14MP0008789_abnormal_olfactory_epithelium1.96696339
15MP0006072_abnormal_retinal_apoptosis1.87383432
16MP0003718_maternal_effect1.84392974
17MP0002751_abnormal_autonomic_nervous1.75920801
18MP0004133_heterotaxia1.74534908
19MP0005394_taste/olfaction_phenotype1.73597824
20MP0005499_abnormal_olfactory_system1.73597824
21MP0001188_hyperpigmentation1.72470172
22MP0006276_abnormal_autonomic_nervous1.66284041
23MP0002736_abnormal_nociception_after1.65246544
24MP0003567_abnormal_fetal_cardiomyocyte1.65108704
25MP0001984_abnormal_olfaction1.65082959
26MP0000778_abnormal_nervous_system1.64933129
27MP0004957_abnormal_blastocyst_morpholog1.64066889
28MP0002938_white_spotting1.63943080
29MP0003111_abnormal_nucleus_morphology1.62279892
30MP0001293_anophthalmia1.55117394
31MP0000372_irregular_coat_pigmentation1.53788390
32MP0009697_abnormal_copulation1.51107522
33MP0005551_abnormal_eye_electrophysiolog1.48057792
34MP0005253_abnormal_eye_physiology1.46732817
35MP0003119_abnormal_digestive_system1.46580652
36MP0001968_abnormal_touch/_nociception1.46254061
37MP0009046_muscle_twitch1.46078224
38MP0003937_abnormal_limbs/digits/tail_de1.42515154
39MP0003077_abnormal_cell_cycle1.39128572
40MP0008932_abnormal_embryonic_tissue1.38535891
41MP0005645_abnormal_hypothalamus_physiol1.37362396
42MP0008995_early_reproductive_senescence1.36503716
43MP0000631_abnormal_neuroendocrine_gland1.33248929
44MP0002234_abnormal_pharynx_morphology1.28284895
45MP0003136_yellow_coat_color1.27373517
46MP0001486_abnormal_startle_reflex1.27072896
47MP0002233_abnormal_nose_morphology1.25226128
48MP0000049_abnormal_middle_ear1.19491063
49MP0000647_abnormal_sebaceous_gland1.15272677
50MP0003195_calcinosis1.14918701
51MP0002272_abnormal_nervous_system1.12705362
52MP0002557_abnormal_social/conspecific_i1.12481227
53MP0002184_abnormal_innervation1.12346879
54MP0008007_abnormal_cellular_replicative1.11391600
55MP0004043_abnormal_pH_regulation1.07625744
56MP0009745_abnormal_behavioral_response1.07492353
57MP0001286_abnormal_eye_development1.06531675
58MP0002653_abnormal_ependyma_morphology1.05341406
59MP0001485_abnormal_pinna_reflex1.04272278
60MP0003861_abnormal_nervous_system1.04197456
61MP0002837_dystrophic_cardiac_calcinosis1.02992602
62MP0005423_abnormal_somatic_nervous1.02668926
63MP0004270_analgesia1.01665690
64MP0003941_abnormal_skin_development1.01338460
65MP0002210_abnormal_sex_determination1.00318787
66MP0003635_abnormal_synaptic_transmissio0.99290994
67MP0003786_premature_aging0.97296478
68MP0001929_abnormal_gametogenesis0.96992567
69MP0002752_abnormal_somatic_nervous0.96832433
70MP0003755_abnormal_palate_morphology0.96577637
71MP0002572_abnormal_emotion/affect_behav0.96270193
72MP0005187_abnormal_penis_morphology0.95181355
73MP0005367_renal/urinary_system_phenotyp0.95017029
74MP0000516_abnormal_urinary_system0.95017029
75MP0009703_decreased_birth_body0.94715933
76MP0005084_abnormal_gallbladder_morpholo0.93698960
77MP0005386_behavior/neurological_phenoty0.92398675
78MP0004924_abnormal_behavior0.92398675
79MP0003123_paternal_imprinting0.92219304
80MP0002822_catalepsy0.92209286
81MP0000955_abnormal_spinal_cord0.92156387
82MP0003698_abnormal_male_reproductive0.88578137
83MP0006035_abnormal_mitochondrial_morpho0.87735039
84MP0004885_abnormal_endolymph0.87204361
85MP0005391_vision/eye_phenotype0.86746665
86MP0001145_abnormal_male_reproductive0.86704241
87MP0000653_abnormal_sex_gland0.86614298
88MP0002638_abnormal_pupillary_reflex0.86553878
89MP0004142_abnormal_muscle_tone0.86413335
90MP0002734_abnormal_mechanical_nocicepti0.86062919
91MP0002063_abnormal_learning/memory/cond0.85090094
92MP0004215_abnormal_myocardial_fiber0.84691627
93MP0001177_atelectasis0.84122929
94MP0002067_abnormal_sensory_capabilities0.84082179
95MP0004811_abnormal_neuron_physiology0.83704554
96MP0002084_abnormal_developmental_patter0.79409126
97MP0009672_abnormal_birth_weight0.79262466
98MP0002882_abnormal_neuron_morphology0.79118165
99MP0002152_abnormal_brain_morphology0.78949143
100MP0005195_abnormal_posterior_eye0.78257359

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.91423280
2Colon cancer (HP:0003003)3.23757453
3Methylmalonic acidemia (HP:0002912)2.88318755
4Pancreatic cysts (HP:0001737)2.82965131
5Pancreatic fibrosis (HP:0100732)2.78750136
6Hyperglycinemia (HP:0002154)2.71042787
7Intestinal atresia (HP:0011100)2.69652782
8Abnormality of midbrain morphology (HP:0002418)2.67917499
9Molar tooth sign on MRI (HP:0002419)2.67917499
10Nephronophthisis (HP:0000090)2.65630426
11Aplasia/Hypoplasia of the uvula (HP:0010293)2.64781604
12Medial flaring of the eyebrow (HP:0010747)2.64644534
13Volvulus (HP:0002580)2.60928404
14Meckel diverticulum (HP:0002245)2.57582733
15Abnormality of chromosome stability (HP:0003220)2.56106994
16Abnormality of the ileum (HP:0001549)2.52585268
17True hermaphroditism (HP:0010459)2.51364818
18Ependymoma (HP:0002888)2.42375793
19Gait imbalance (HP:0002141)2.39155918
20Methylmalonic aciduria (HP:0012120)2.35372453
21Congenital primary aphakia (HP:0007707)2.32538397
22Abnormality of the renal medulla (HP:0100957)2.28166731
23Nephrogenic diabetes insipidus (HP:0009806)2.23755132
24Increased hepatocellular lipid droplets (HP:0006565)2.23654211
25Genital tract atresia (HP:0001827)2.21739449
26Acute necrotizing encephalopathy (HP:0006965)2.18983092
27Acute encephalopathy (HP:0006846)2.18693047
28Lissencephaly (HP:0001339)2.16933777
29Pendular nystagmus (HP:0012043)2.16162185
30Neoplasm of the adrenal cortex (HP:0100641)2.12469120
31Vaginal atresia (HP:0000148)2.12309392
32Renal cortical cysts (HP:0000803)2.10755817
33Abnormality of the renal cortex (HP:0011035)2.09499951
34Birth length less than 3rd percentile (HP:0003561)2.09137078
35Broad-based gait (HP:0002136)2.07498385
36Chronic hepatic failure (HP:0100626)2.05374778
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03981370
38Chromsome breakage (HP:0040012)2.03623986
39Abnormal lung lobation (HP:0002101)2.02408825
40Supernumerary spleens (HP:0009799)2.02339838
41Abnormality of the preputium (HP:0100587)2.00619106
42Glioma (HP:0009733)2.00406377
43Progressive macrocephaly (HP:0004481)1.99234005
44Abolished electroretinogram (ERG) (HP:0000550)1.98950447
45Hyperventilation (HP:0002883)1.98745989
46Lipid accumulation in hepatocytes (HP:0006561)1.97309343
47Abnormality of serum amino acid levels (HP:0003112)1.96866173
48Increased CSF lactate (HP:0002490)1.95072292
49Drooling (HP:0002307)1.94495106
50Abnormality of the astrocytes (HP:0100707)1.93666779
51Astrocytoma (HP:0009592)1.93666779
52Sloping forehead (HP:0000340)1.93459341
53Abnormality of glycine metabolism (HP:0010895)1.91845660
54Abnormality of serine family amino acid metabolism (HP:0010894)1.91845660
55Hepatoblastoma (HP:0002884)1.87959815
56Progressive inability to walk (HP:0002505)1.87706984
57Optic nerve hypoplasia (HP:0000609)1.87578024
58Bifid tongue (HP:0010297)1.87050337
59Hypothermia (HP:0002045)1.84272667
60Aplasia/Hypoplasia of the tibia (HP:0005772)1.83328510
61Sclerocornea (HP:0000647)1.83148804
62Oligodactyly (hands) (HP:0001180)1.83052432
63Abnormality of the duodenum (HP:0002246)1.82694304
64Abnormality of vitamin B metabolism (HP:0004340)1.82420509
65Hyperglycinuria (HP:0003108)1.82261314
66Mitochondrial inheritance (HP:0001427)1.81367139
67Septo-optic dysplasia (HP:0100842)1.80973872
68Patellar aplasia (HP:0006443)1.80507462
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80031447
70Dandy-Walker malformation (HP:0001305)1.80008411
71Duodenal stenosis (HP:0100867)1.78527075
72Small intestinal stenosis (HP:0012848)1.78527075
73Impaired vibration sensation in the lower limbs (HP:0002166)1.77396332
74Abnormal mitochondria in muscle tissue (HP:0008316)1.76813611
75Hypoplasia of the pons (HP:0012110)1.76241199
76Neoplasm of the adrenal gland (HP:0100631)1.75914119
77Gastrointestinal atresia (HP:0002589)1.75609588
78Abnormality of the pons (HP:0007361)1.74156692
79Poor coordination (HP:0002370)1.73670499
80Medulloblastoma (HP:0002885)1.73000933
81Astigmatism (HP:0000483)1.72915850
82Abnormality of the vitamin B12 metabolism (HP:0004341)1.72644105
83Cortical dysplasia (HP:0002539)1.72591601
84Bile duct proliferation (HP:0001408)1.72444708
85Abnormal biliary tract physiology (HP:0012439)1.72444708
86Pachygyria (HP:0001302)1.72327847
87Small hand (HP:0200055)1.71896830
88Aplasia/Hypoplasia of the sternum (HP:0006714)1.71733355
89Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71342226
90Nephroblastoma (Wilms tumor) (HP:0002667)1.71152090
91Limb dystonia (HP:0002451)1.70785447
92Specific learning disability (HP:0001328)1.70232107
93Rhabdomyosarcoma (HP:0002859)1.70103041
94Anencephaly (HP:0002323)1.69571610
95Excessive salivation (HP:0003781)1.69502642
96Broad foot (HP:0001769)1.69320649
97Hyperalaninemia (HP:0003348)1.69022502
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69022502
99Abnormality of alanine metabolism (HP:0010916)1.69022502
100Embryonal renal neoplasm (HP:0011794)1.68074051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.17633877
2CASK2.88742215
3FRK2.72877985
4MAP3K42.71855054
5MKNK22.63899203
6MARK12.52119005
7SRPK12.48938290
8ZAK2.45728873
9BMPR1B2.43332932
10TRIM282.40956227
11MAP4K22.39145858
12CDC72.17651254
13NUAK12.10618604
14MKNK12.09902421
15TSSK61.95142574
16TNIK1.93083487
17DYRK21.84672899
18MAPK131.84370045
19PLK31.84090682
20BCR1.83918984
21PLK41.81271329
22BUB11.80248455
23BRSK21.75480466
24TTK1.72773775
25MAP2K71.72422777
26EIF2AK31.63955551
27MST41.45625855
28WEE11.44848804
29ACVR1B1.36344947
30VRK11.36119337
31TAF11.28541547
32CSNK1G11.28298168
33NEK11.26824483
34CSNK1G21.23467350
35PNCK1.23407089
36ERBB31.18808313
37GRK11.16744751
38PLK11.15678356
39CSNK1G31.12591792
40DYRK31.07605596
41ADRBK21.05988392
42PLK20.98027508
43CSNK1A1L0.97502893
44PBK0.97340712
45VRK20.91572721
46OXSR10.91169982
47ATR0.89260592
48CHEK20.88662653
49BRD40.88369326
50PAK30.87795773
51WNK40.83543800
52STK160.80197160
53ATM0.79082635
54EPHA40.77706499
55TGFBR10.77139851
56NME10.76960760
57PRKCG0.74863308
58CDK190.74045583
59INSRR0.72837770
60STK390.71380197
61PRKCE0.68131658
62MAP2K40.63647974
63CDK30.63393734
64YES10.62526876
65MINK10.60806629
66STK38L0.60008923
67EIF2AK10.58317127
68PINK10.55544726
69RPS6KA40.54285355
70BRSK10.54247991
71CHEK10.53890130
72CSNK1E0.52638396
73STK30.52419916
74EIF2AK20.52067374
75FGFR20.50670102
76BCKDK0.50634287
77FGFR10.46534294
78DYRK1A0.45863898
79PRKDC0.43723985
80NTRK20.42523083
81CDK10.41255999
82DAPK20.40252554
83ERBB40.39858994
84AURKB0.39771933
85PASK0.39575576
86MAP3K120.39425676
87CSNK1D0.39374916
88AKT30.38569098
89CSNK1A10.37956550
90PKN10.37682105
91FLT30.37046704
92NTRK30.35733149
93NLK0.35513247
94TIE10.35330514
95CCNB10.34959012
96CSNK2A10.34065615
97CDK20.33084417
98CAMK2A0.32516610
99CSNK2A20.31861826
100NEK20.31791410

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.24684662
2Protein export_Homo sapiens_hsa030602.90932938
3RNA polymerase_Homo sapiens_hsa030202.60154009
4Basal transcription factors_Homo sapiens_hsa030222.57593360
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48286673
6Mismatch repair_Homo sapiens_hsa034302.48125215
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46909769
8Fanconi anemia pathway_Homo sapiens_hsa034602.45798210
9Homologous recombination_Homo sapiens_hsa034402.32729068
10Propanoate metabolism_Homo sapiens_hsa006402.30288425
11Proteasome_Homo sapiens_hsa030502.19329006
12Steroid biosynthesis_Homo sapiens_hsa001002.12942530
13RNA degradation_Homo sapiens_hsa030182.05670668
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.01655466
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96831701
16RNA transport_Homo sapiens_hsa030131.95244109
17Oxidative phosphorylation_Homo sapiens_hsa001901.94285767
18DNA replication_Homo sapiens_hsa030301.88347805
19Spliceosome_Homo sapiens_hsa030401.82587074
20Selenocompound metabolism_Homo sapiens_hsa004501.82508604
21Nicotine addiction_Homo sapiens_hsa050331.80782512
22Parkinsons disease_Homo sapiens_hsa050121.74655260
23Base excision repair_Homo sapiens_hsa034101.73900899
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65619571
25Butanoate metabolism_Homo sapiens_hsa006501.64978115
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61214628
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58391746
28Phototransduction_Homo sapiens_hsa047441.56832983
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50357414
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.43182204
31Nucleotide excision repair_Homo sapiens_hsa034201.37664829
32One carbon pool by folate_Homo sapiens_hsa006701.37311043
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36016384
34Huntingtons disease_Homo sapiens_hsa050161.31597743
35Cell cycle_Homo sapiens_hsa041101.29703955
36mRNA surveillance pathway_Homo sapiens_hsa030151.27442533
37Purine metabolism_Homo sapiens_hsa002301.17220385
38Pyrimidine metabolism_Homo sapiens_hsa002401.16683808
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13466107
40Taste transduction_Homo sapiens_hsa047421.11263673
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10594634
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09267480
43Fatty acid elongation_Homo sapiens_hsa000621.05354663
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02410190
45Pyruvate metabolism_Homo sapiens_hsa006200.99310567
46Caffeine metabolism_Homo sapiens_hsa002320.97045472
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95346379
48Alzheimers disease_Homo sapiens_hsa050100.94756986
49Vitamin B6 metabolism_Homo sapiens_hsa007500.91559528
50Tryptophan metabolism_Homo sapiens_hsa003800.87989081
51Oocyte meiosis_Homo sapiens_hsa041140.87885047
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83120456
53Peroxisome_Homo sapiens_hsa041460.82320638
54Nitrogen metabolism_Homo sapiens_hsa009100.77610980
55GABAergic synapse_Homo sapiens_hsa047270.76955509
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73643281
57Ribosome_Homo sapiens_hsa030100.69561578
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.69214740
59Fatty acid metabolism_Homo sapiens_hsa012120.67667641
60Metabolic pathways_Homo sapiens_hsa011000.67143373
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65269375
62Ether lipid metabolism_Homo sapiens_hsa005650.65238436
63p53 signaling pathway_Homo sapiens_hsa041150.64780121
64Olfactory transduction_Homo sapiens_hsa047400.62151727
65Linoleic acid metabolism_Homo sapiens_hsa005910.61668443
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59903132
67beta-Alanine metabolism_Homo sapiens_hsa004100.57994083
68Morphine addiction_Homo sapiens_hsa050320.57826230
69Cardiac muscle contraction_Homo sapiens_hsa042600.55644282
70Glutamatergic synapse_Homo sapiens_hsa047240.54933678
71Dopaminergic synapse_Homo sapiens_hsa047280.54447806
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54319658
73Sulfur metabolism_Homo sapiens_hsa009200.53546178
74Folate biosynthesis_Homo sapiens_hsa007900.53411921
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53088668
76Regulation of autophagy_Homo sapiens_hsa041400.51361643
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50028647
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49783507
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48940820
80Serotonergic synapse_Homo sapiens_hsa047260.47610759
81Hedgehog signaling pathway_Homo sapiens_hsa043400.46810416
82Lysine degradation_Homo sapiens_hsa003100.44066078
83Retinol metabolism_Homo sapiens_hsa008300.43820470
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42973200
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.40978526
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40912933
87Alcoholism_Homo sapiens_hsa050340.40133449
88Wnt signaling pathway_Homo sapiens_hsa043100.39388510
89Axon guidance_Homo sapiens_hsa043600.39181859
90TGF-beta signaling pathway_Homo sapiens_hsa043500.37746384
91Basal cell carcinoma_Homo sapiens_hsa052170.37622711
92Hippo signaling pathway_Homo sapiens_hsa043900.37577620
93Circadian entrainment_Homo sapiens_hsa047130.37080282
94Carbon metabolism_Homo sapiens_hsa012000.35707884
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35659280
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34656326
97Glutathione metabolism_Homo sapiens_hsa004800.34211853
98Amphetamine addiction_Homo sapiens_hsa050310.33304063
99Fatty acid degradation_Homo sapiens_hsa000710.33164294
100Cocaine addiction_Homo sapiens_hsa050300.33153666

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