ZNF197

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.06422591
2presynaptic membrane assembly (GO:0097105)4.25990061
3nucleobase catabolic process (GO:0046113)4.15524949
4behavioral response to nicotine (GO:0035095)4.06115159
5neuron cell-cell adhesion (GO:0007158)3.99904979
6presynaptic membrane organization (GO:0097090)3.93671238
7neural tube formation (GO:0001841)3.67062529
8postsynaptic membrane organization (GO:0001941)3.49941174
9retinal ganglion cell axon guidance (GO:0031290)3.46883001
10protein localization to cilium (GO:0061512)3.45554926
11neuron recognition (GO:0008038)3.40285803
12axonal fasciculation (GO:0007413)3.37192747
13dendritic spine morphogenesis (GO:0060997)3.25665050
14DNA double-strand break processing (GO:0000729)3.22642449
15limb bud formation (GO:0060174)3.21077755
16olfactory bulb development (GO:0021772)3.18394616
17intraciliary transport (GO:0042073)3.16226105
18mechanosensory behavior (GO:0007638)3.12245163
19nonmotile primary cilium assembly (GO:0035058)3.11405422
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10078936
21head development (GO:0060322)3.09240898
22auditory behavior (GO:0031223)3.06636998
23epithelial cilium movement (GO:0003351)3.05345986
24somite development (GO:0061053)3.04102060
25central nervous system projection neuron axonogenesis (GO:0021952)2.93461943
26negative regulation of cytosolic calcium ion concentration (GO:0051481)2.91095209
27negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.88795681
28negative regulation of axon guidance (GO:1902668)2.87127499
29cerebral cortex radially oriented cell migration (GO:0021799)2.83827897
30establishment of mitochondrion localization (GO:0051654)2.81632813
31central nervous system neuron axonogenesis (GO:0021955)2.78721877
32response to pheromone (GO:0019236)2.76444783
33forebrain neuron differentiation (GO:0021879)2.75721534
34centriole replication (GO:0007099)2.74312406
35negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73317893
36negative regulation of translation, ncRNA-mediated (GO:0040033)2.73317893
37regulation of translation, ncRNA-mediated (GO:0045974)2.73317893
38synapse assembly (GO:0007416)2.73127245
39regulation of collateral sprouting (GO:0048670)2.71828544
40protein polyglutamylation (GO:0018095)2.71469711
41G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71407748
42neurotransmitter-gated ion channel clustering (GO:0072578)2.69459845
43microtubule anchoring (GO:0034453)2.68925774
44kidney morphogenesis (GO:0060993)2.68876359
45protein localization to synapse (GO:0035418)2.68344682
46calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.66876011
47negative regulation of dendrite development (GO:2000171)2.66281281
48hindbrain development (GO:0030902)2.66044501
49sympathetic nervous system development (GO:0048485)2.64357012
50regulation of short-term neuronal synaptic plasticity (GO:0048172)2.60521306
51cornea development in camera-type eye (GO:0061303)2.60289028
52cilium morphogenesis (GO:0060271)2.58868919
53regulation of telomere maintenance (GO:0032204)2.58734028
54cilium organization (GO:0044782)2.58706385
55inner ear receptor stereocilium organization (GO:0060122)2.58367087
56appendage development (GO:0048736)2.58312959
57limb development (GO:0060173)2.58312959
58establishment of protein localization to Golgi (GO:0072600)2.58172950
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.58062930
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57659149
61atrial cardiac muscle cell action potential (GO:0086014)2.57390559
62ganglion development (GO:0061548)2.56295598
63cilium assembly (GO:0042384)2.55750496
64transmission of nerve impulse (GO:0019226)2.54596695
65cerebellar Purkinje cell differentiation (GO:0021702)2.52027061
66behavioral response to ethanol (GO:0048149)2.49484476
67regulation of development, heterochronic (GO:0040034)2.48701885
68spinal cord development (GO:0021510)2.48367528
69regulation of non-canonical Wnt signaling pathway (GO:2000050)2.48157539
70cell migration in hindbrain (GO:0021535)2.46468797
71cilium movement (GO:0003341)2.46418539
72protein targeting to Golgi (GO:0000042)2.45929139
73neuromuscular synaptic transmission (GO:0007274)2.45567081
74dendrite morphogenesis (GO:0048813)2.41801916
75photoreceptor cell maintenance (GO:0045494)2.40646905
76protein localization to Golgi apparatus (GO:0034067)2.39440581
77pyrimidine dimer repair (GO:0006290)2.39174157
78neuron migration (GO:0001764)2.38559967
79cell differentiation in spinal cord (GO:0021515)2.38511422
80resolution of meiotic recombination intermediates (GO:0000712)2.34837537
81negative regulation of synaptic transmission, GABAergic (GO:0032229)2.34688174
82gamma-aminobutyric acid transport (GO:0015812)2.34351066
83synaptic transmission, cholinergic (GO:0007271)2.32024090
84microtubule depolymerization (GO:0007019)2.30835309
85spinal cord motor neuron differentiation (GO:0021522)2.30754969
86regulation of cilium movement (GO:0003352)2.29990337
87regulation of timing of cell differentiation (GO:0048505)2.29417160
88negative regulation of DNA recombination (GO:0045910)2.28226684
89axoneme assembly (GO:0035082)2.27762816
90histone H2A monoubiquitination (GO:0035518)2.27453065
91C4-dicarboxylate transport (GO:0015740)2.26977195
92regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.26772489
93establishment of nucleus localization (GO:0040023)2.26371993
94homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.26276962
95neuronal action potential (GO:0019228)2.26234275
96forebrain morphogenesis (GO:0048853)2.26046804
97startle response (GO:0001964)2.26038855
98dendrite development (GO:0016358)2.25809197
99retinal cone cell development (GO:0046549)2.25684513
100regulation of hexokinase activity (GO:1903299)2.25486199

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.38872557
2GBX2_23144817_ChIP-Seq_PC3_Human3.30515128
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.15730624
4ZNF274_21170338_ChIP-Seq_K562_Hela3.00895265
5IGF1R_20145208_ChIP-Seq_DFB_Human2.88102582
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.86044015
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.82792931
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.68590366
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55948384
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.52349876
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48522764
12TAF15_26573619_Chip-Seq_HEK293_Human2.43352107
13FUS_26573619_Chip-Seq_HEK293_Human2.43287951
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31276734
15EWS_26573619_Chip-Seq_HEK293_Human2.30041281
16VDR_22108803_ChIP-Seq_LS180_Human2.19203880
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14723214
18P300_19829295_ChIP-Seq_ESCs_Human2.07978026
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.00700852
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96609585
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88146791
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85211670
23SMAD4_21799915_ChIP-Seq_A2780_Human1.83067070
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76475897
25MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.75263705
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.71729064
27RNF2_27304074_Chip-Seq_NSC_Mouse1.68915095
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65799643
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63195516
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61701640
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61499968
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60723435
33ER_23166858_ChIP-Seq_MCF-7_Human1.59665798
34STAT3_23295773_ChIP-Seq_U87_Human1.57521428
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.57515162
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.57375898
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56539639
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56106458
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51432932
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51432932
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50996656
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50695583
43REST_21632747_ChIP-Seq_MESCs_Mouse1.50291894
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.49931047
45CBP_20019798_ChIP-Seq_JUKART_Human1.47281142
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47281142
47AR_25329375_ChIP-Seq_VCAP_Human1.44864097
48* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44125906
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.42533073
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42185251
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42028246
52IRF1_19129219_ChIP-ChIP_H3396_Human1.40506378
53TCF4_23295773_ChIP-Seq_U87_Human1.39949283
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39145167
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36313930
56* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33608153
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32702034
58AR_21572438_ChIP-Seq_LNCaP_Human1.28657721
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.28195477
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27543291
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.25958682
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24953981
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23322575
64RUNX2_22187159_ChIP-Seq_PCA_Human1.23153591
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22660186
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21278797
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20914551
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19961876
69BCAT_22108803_ChIP-Seq_LS180_Human1.19154819
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18866368
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18655371
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.18048652
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.16966335
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16194500
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16054736
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14918582
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14619393
78* MYC_18940864_ChIP-ChIP_HL60_Human1.13847708
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13847008
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11781571
81SOX9_26525672_Chip-Seq_HEART_Mouse1.11665621
82JUN_21703547_ChIP-Seq_K562_Human1.11285194
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.10876648
84P53_22387025_ChIP-Seq_ESCs_Mouse1.09819776
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.08782228
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.07925558
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.07088595
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06629346
89TP53_22573176_ChIP-Seq_HFKS_Human1.06612969
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.05821227
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.04617372
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04290468
93TCF4_22108803_ChIP-Seq_LS180_Human1.03278158
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02405026
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00709109
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00245527
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98441789
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96665945
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95915173
100TP53_16413492_ChIP-PET_HCT116_Human0.95705933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.41155557
2MP0003890_abnormal_embryonic-extraembry2.67379146
3MP0000778_abnormal_nervous_system2.58762256
4MP0006276_abnormal_autonomic_nervous2.50977431
5MP0001984_abnormal_olfaction2.38780705
6MP0000569_abnormal_digit_pigmentation2.37390200
7MP0003122_maternal_imprinting2.34330084
8MP0006292_abnormal_olfactory_placode2.29862536
9MP0002102_abnormal_ear_morphology2.23796111
10MP0008877_abnormal_DNA_methylation2.22434814
11MP0003787_abnormal_imprinting2.02618368
12MP0003121_genomic_imprinting2.01782339
13MP0001529_abnormal_vocalization2.01131018
14MP0002822_catalepsy1.97073386
15MP0002837_dystrophic_cardiac_calcinosis1.91628003
16MP0002638_abnormal_pupillary_reflex1.87725262
17MP0005645_abnormal_hypothalamus_physiol1.76707042
18MP0004885_abnormal_endolymph1.70243033
19MP0006072_abnormal_retinal_apoptosis1.69993535
20MP0008789_abnormal_olfactory_epithelium1.66892911
21MP0005499_abnormal_olfactory_system1.64898304
22MP0005394_taste/olfaction_phenotype1.64898304
23MP0005551_abnormal_eye_electrophysiolog1.59571138
24MP0004859_abnormal_synaptic_plasticity1.56838006
25MP0005253_abnormal_eye_physiology1.56816663
26MP0001188_hyperpigmentation1.53006863
27MP0002272_abnormal_nervous_system1.51515653
28MP0000631_abnormal_neuroendocrine_gland1.50713020
29MP0004270_analgesia1.48080631
30MP0004133_heterotaxia1.47907474
31MP0005423_abnormal_somatic_nervous1.44821258
32MP0003635_abnormal_synaptic_transmissio1.44056921
33MP0002234_abnormal_pharynx_morphology1.43996855
34MP0009046_muscle_twitch1.42845990
35MP0004145_abnormal_muscle_electrophysio1.42810452
36MP0009745_abnormal_behavioral_response1.42789696
37MP0002184_abnormal_innervation1.40939445
38MP0002557_abnormal_social/conspecific_i1.40580223
39MP0000955_abnormal_spinal_cord1.39916757
40MP0002751_abnormal_autonomic_nervous1.37366224
41MP0002063_abnormal_learning/memory/cond1.34242679
42MP0005187_abnormal_penis_morphology1.33061847
43MP0002734_abnormal_mechanical_nocicepti1.32960577
44MP0002653_abnormal_ependyma_morphology1.32073676
45MP0002572_abnormal_emotion/affect_behav1.30873522
46MP0003136_yellow_coat_color1.30517006
47MP0004811_abnormal_neuron_physiology1.30245444
48MP0000427_abnormal_hair_cycle1.27514518
49MP0002938_white_spotting1.27310936
50MP0004142_abnormal_muscle_tone1.26653156
51MP0004924_abnormal_behavior1.25907619
52MP0005386_behavior/neurological_phenoty1.25907619
53MP0000372_irregular_coat_pigmentation1.25857789
54MP0003937_abnormal_limbs/digits/tail_de1.25688648
55MP0009697_abnormal_copulation1.24801840
56MP0001486_abnormal_startle_reflex1.23200124
57MP0002752_abnormal_somatic_nervous1.21881582
58MP0002882_abnormal_neuron_morphology1.21628320
59MP0002233_abnormal_nose_morphology1.21022748
60MP0001968_abnormal_touch/_nociception1.20018763
61MP0001293_anophthalmia1.18291878
62MP0002928_abnormal_bile_duct1.17732316
63MP0000049_abnormal_middle_ear1.17623736
64MP0004742_abnormal_vestibular_system1.17113426
65MP0002067_abnormal_sensory_capabilities1.15307289
66MP0003119_abnormal_digestive_system1.11210440
67MP0002736_abnormal_nociception_after1.10541336
68MP0008058_abnormal_DNA_repair1.08981449
69MP0003861_abnormal_nervous_system1.08811730
70MP0002735_abnormal_chemical_nociception1.08143622
71MP0001286_abnormal_eye_development1.07529095
72MP0004215_abnormal_myocardial_fiber1.04892495
73MP0005195_abnormal_posterior_eye1.03494910
74MP0002152_abnormal_brain_morphology1.02285485
75MP0001485_abnormal_pinna_reflex0.99912582
76MP0002064_seizures0.98573575
77MP0005391_vision/eye_phenotype0.98117270
78MP0003755_abnormal_palate_morphology0.97584994
79MP0000516_abnormal_urinary_system0.96616558
80MP0005367_renal/urinary_system_phenotyp0.96616558
81MP0008995_early_reproductive_senescence0.94051189
82MP0001970_abnormal_pain_threshold0.93598554
83MP0002160_abnormal_reproductive_system0.92214520
84MP0001299_abnormal_eye_distance/0.91322128
85MP0003195_calcinosis0.89975776
86MP0002282_abnormal_trachea_morphology0.88815893
87MP0002876_abnormal_thyroid_physiology0.88273274
88MP0001502_abnormal_circadian_rhythm0.87139982
89MP0005646_abnormal_pituitary_gland0.85505941
90MP0003283_abnormal_digestive_organ0.83970422
91MP0000647_abnormal_sebaceous_gland0.83422006
92MP0002095_abnormal_skin_pigmentation0.82652514
93MP0000026_abnormal_inner_ear0.81403382
94MP0001986_abnormal_taste_sensitivity0.79960564
95MP0001177_atelectasis0.79465471
96MP0005248_abnormal_Harderian_gland0.79375391
97MP0003646_muscle_fatigue0.78974995
98MP0001324_abnormal_eye_pigmentation0.78214930
99MP0003698_abnormal_male_reproductive0.77457082
100MP0003385_abnormal_body_wall0.77005240

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)3.67327535
2Pancreatic cysts (HP:0001737)3.59038177
3Gait imbalance (HP:0002141)3.24007022
4True hermaphroditism (HP:0010459)3.20970423
5Medial flaring of the eyebrow (HP:0010747)3.20903859
6Drooling (HP:0002307)3.13358391
7Congenital primary aphakia (HP:0007707)3.04110521
8Nephrogenic diabetes insipidus (HP:0009806)3.03293972
9Chronic hepatic failure (HP:0100626)2.96418035
10Nephronophthisis (HP:0000090)2.94054188
11Intestinal atresia (HP:0011100)2.91151620
12Genital tract atresia (HP:0001827)2.82588242
13Abnormality of midbrain morphology (HP:0002418)2.80930902
14Molar tooth sign on MRI (HP:0002419)2.80930902
15Excessive salivation (HP:0003781)2.80869069
16Abnormality of the renal medulla (HP:0100957)2.70222978
17Vaginal atresia (HP:0000148)2.70175592
18Progressive inability to walk (HP:0002505)2.60122646
19Hyperventilation (HP:0002883)2.59587738
20Abnormality of the labia minora (HP:0012880)2.59282784
21Lissencephaly (HP:0001339)2.48871455
22Poor coordination (HP:0002370)2.46879417
23Abnormality of the renal cortex (HP:0011035)2.38532543
24Progressive cerebellar ataxia (HP:0002073)2.36648400
25Type II lissencephaly (HP:0007260)2.34779516
26Inability to walk (HP:0002540)2.33761809
27Broad-based gait (HP:0002136)2.32494680
28Chorioretinal atrophy (HP:0000533)2.26441034
29Cystic liver disease (HP:0006706)2.25347282
30Specific learning disability (HP:0001328)2.25329840
31Small hand (HP:0200055)2.25278053
32Congenital stationary night blindness (HP:0007642)2.22327158
33Volvulus (HP:0002580)2.21059519
34Cerebellar dysplasia (HP:0007033)2.20873211
35Oligodactyly (hands) (HP:0001180)2.19318364
36Optic nerve hypoplasia (HP:0000609)2.18249270
37Febrile seizures (HP:0002373)2.17784665
38Absent speech (HP:0001344)2.17534890
39Pachygyria (HP:0001302)2.13339445
40Colon cancer (HP:0003003)2.12969171
41Polyphagia (HP:0002591)2.09449230
42Narrow forehead (HP:0000341)2.08342732
43Abnormality of the corticospinal tract (HP:0002492)2.06489245
44Postaxial hand polydactyly (HP:0001162)2.06234899
45Postaxial foot polydactyly (HP:0001830)2.05454993
46Focal motor seizures (HP:0011153)2.04515313
47Focal seizures (HP:0007359)2.02627078
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.01579325
49Hip dysplasia (HP:0001385)1.96065137
50Sclerocornea (HP:0000647)1.94985700
51Abnormal hair whorl (HP:0010721)1.94783461
52Anencephaly (HP:0002323)1.94219999
53Tubulointerstitial nephritis (HP:0001970)1.93818939
54Hepatoblastoma (HP:0002884)1.92645548
55Pendular nystagmus (HP:0012043)1.92463052
56Limb dystonia (HP:0002451)1.92347259
57Short foot (HP:0001773)1.91362146
58Neoplasm of the adrenal cortex (HP:0100641)1.91165057
59Atonic seizures (HP:0010819)1.90467967
60Anophthalmia (HP:0000528)1.90460120
61Cortical dysplasia (HP:0002539)1.89791002
62Amblyopia (HP:0000646)1.88131595
63Tubulointerstitial abnormality (HP:0001969)1.84728016
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83828964
65Genetic anticipation (HP:0003743)1.83412838
66Abolished electroretinogram (ERG) (HP:0000550)1.82852210
67Tubular atrophy (HP:0000092)1.81360074
68Abnormal pancreas size (HP:0012094)1.81126698
69Protruding tongue (HP:0010808)1.80610508
70Gastrointestinal atresia (HP:0002589)1.80258312
71Degeneration of the lateral corticospinal tracts (HP:0002314)1.78750896
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78750896
73Septo-optic dysplasia (HP:0100842)1.78658743
74Astigmatism (HP:0000483)1.77906739
75Dandy-Walker malformation (HP:0001305)1.77634982
76Vitreoretinal degeneration (HP:0000655)1.76759006
77Shawl scrotum (HP:0000049)1.76679831
78Occipital encephalocele (HP:0002085)1.74938794
79Retinal dysplasia (HP:0007973)1.73803433
80Gaze-evoked nystagmus (HP:0000640)1.71514639
81Renal cortical cysts (HP:0000803)1.71122661
82Exotropia (HP:0000577)1.70637826
83Micropenis (HP:0000054)1.70427113
84Aplasia/Hypoplasia of the lens (HP:0008063)1.70064309
85Supernumerary spleens (HP:0009799)1.68776444
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.68251689
87Epileptic encephalopathy (HP:0200134)1.68162439
88Congenital hepatic fibrosis (HP:0002612)1.67995265
89Furrowed tongue (HP:0000221)1.67743348
90Prominent nasal bridge (HP:0000426)1.66659227
91Multicystic kidney dysplasia (HP:0000003)1.65473572
92Spastic tetraplegia (HP:0002510)1.65171720
93Aqueductal stenosis (HP:0002410)1.65002651
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.64193221
95Renal hypoplasia (HP:0000089)1.63992402
96Bony spicule pigmentary retinopathy (HP:0007737)1.63985184
97Impaired vibration sensation in the lower limbs (HP:0002166)1.63764678
98Abnormal rod and cone electroretinograms (HP:0008323)1.63754215
99Broad foot (HP:0001769)1.63370477
100Abnormality of the ischium (HP:0003174)1.63066125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.19662218
2CASK3.28415134
3MARK13.26538251
4BCR2.86730728
5WNK32.80640313
6MAP3K42.77882100
7BMPR1B2.35315482
8TNIK2.16270596
9MAPK132.15931708
10TRIM281.90034106
11PINK11.87636123
12MAP2K71.82645812
13PNCK1.75854874
14NUAK11.70662100
15MKNK21.65070286
16ERBB31.52343712
17ADRBK21.51653551
18LATS11.49203890
19DYRK31.43001263
20CSNK1G11.39275415
21FGFR21.39202161
22BRSK21.38473477
23DYRK21.36909056
24CSNK1G21.31788995
25WNK41.28799622
26ACVR1B1.24159652
27SGK21.23191291
28WEE11.22583929
29EPHB21.17151428
30PAK31.16958973
31NTRK31.16533396
32UHMK11.14923888
33STK391.14639651
34STK38L1.14297354
35MAP4K21.13979867
36MKNK11.13104661
37CDK31.12104353
38PLK41.11658848
39NTRK21.10078668
40PLK21.09994093
41AKT31.05737932
42CSNK1G31.04045800
43MINK11.03771414
44CSNK1A1L1.03395332
45OBSCN1.02103582
46SGK4940.98894642
47SGK2230.98894642
48ZAK0.98489817
49GRK10.98156908
50INSRR0.97311336
51MAP2K40.93545070
52PRKCG0.92290381
53CAMK1G0.92273150
54SRPK10.91375227
55BRD40.86070148
56EPHA40.75667848
57NLK0.74834560
58NEK20.74315440
59PLK30.74010788
60EIF2AK30.73800588
61RPS6KA40.71471466
62PRKCE0.71344629
63DYRK1A0.70226081
64OXSR10.69475523
65CAMKK20.69326213
66CAMK1D0.69248986
67KSR10.68995267
68STK30.67529495
69SIK20.65446278
70CAMK40.61695490
71PLK10.60649784
72CDC70.58033501
73DYRK1B0.57903160
74STK110.57770864
75EPHA30.55435795
76PKN10.52411141
77CAMK2A0.51622150
78CCNB10.50165282
79PRKAA10.50058899
80CAMK10.49865695
81PHKG20.49760899
82PHKG10.49760899
83SGK30.49257416
84PASK0.49136418
85ATM0.48563536
86TTK0.47432126
87SIK30.47231886
88FER0.47133836
89CDK50.45771158
90ADRBK10.43669705
91WNK10.41807787
92VRK10.41282931
93CSNK1E0.40282451
94CSNK1D0.39641615
95CDK190.35306576
96PRKCZ0.35105026
97TGFBR10.34977987
98ATR0.34632588
99PRKACA0.34378571
100CSNK1A10.34263990

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.35950539
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.02743830
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.69307628
4Phototransduction_Homo sapiens_hsa047442.61134198
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.23437822
6Protein export_Homo sapiens_hsa030602.16038129
7Fanconi anemia pathway_Homo sapiens_hsa034601.93110139
8GABAergic synapse_Homo sapiens_hsa047271.91767262
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87704065
10Butanoate metabolism_Homo sapiens_hsa006501.86608487
11Glutamatergic synapse_Homo sapiens_hsa047241.83316961
12Morphine addiction_Homo sapiens_hsa050321.79116584
13Basal transcription factors_Homo sapiens_hsa030221.78097662
14Steroid biosynthesis_Homo sapiens_hsa001001.76720560
15Taste transduction_Homo sapiens_hsa047421.74177321
16Cocaine addiction_Homo sapiens_hsa050301.70250563
17Circadian entrainment_Homo sapiens_hsa047131.68299534
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63760982
19Dopaminergic synapse_Homo sapiens_hsa047281.59876095
20Hedgehog signaling pathway_Homo sapiens_hsa043401.56555003
21RNA degradation_Homo sapiens_hsa030181.51898839
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.50430778
23Axon guidance_Homo sapiens_hsa043601.50232082
24Selenocompound metabolism_Homo sapiens_hsa004501.48406070
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48092742
26Non-homologous end-joining_Homo sapiens_hsa034501.47810988
27Propanoate metabolism_Homo sapiens_hsa006401.41260211
28Circadian rhythm_Homo sapiens_hsa047101.37166122
29Olfactory transduction_Homo sapiens_hsa047401.35996452
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30080217
31Linoleic acid metabolism_Homo sapiens_hsa005911.26651606
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26277849
33Ether lipid metabolism_Homo sapiens_hsa005651.26164857
34Insulin secretion_Homo sapiens_hsa049111.25519880
35Serotonergic synapse_Homo sapiens_hsa047261.24134299
36Basal cell carcinoma_Homo sapiens_hsa052171.24059771
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23115561
38Long-term depression_Homo sapiens_hsa047301.17929605
39Cardiac muscle contraction_Homo sapiens_hsa042601.16122976
40Cholinergic synapse_Homo sapiens_hsa047251.12757419
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12484412
42Homologous recombination_Homo sapiens_hsa034401.12448111
43Amphetamine addiction_Homo sapiens_hsa050311.11491734
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04496504
45Hippo signaling pathway_Homo sapiens_hsa043901.02717638
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02278790
47Parkinsons disease_Homo sapiens_hsa050121.02256579
48Nitrogen metabolism_Homo sapiens_hsa009101.00220309
49Oxidative phosphorylation_Homo sapiens_hsa001900.99671175
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94332994
51mRNA surveillance pathway_Homo sapiens_hsa030150.91151999
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91038904
53Dorso-ventral axis formation_Homo sapiens_hsa043200.89633470
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.89347520
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89131045
56Oocyte meiosis_Homo sapiens_hsa041140.88188052
57Alcoholism_Homo sapiens_hsa050340.84599929
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83519738
59Regulation of autophagy_Homo sapiens_hsa041400.82265009
60Melanogenesis_Homo sapiens_hsa049160.81005434
61cAMP signaling pathway_Homo sapiens_hsa040240.77736577
62Wnt signaling pathway_Homo sapiens_hsa043100.76332699
63Peroxisome_Homo sapiens_hsa041460.76238496
64Synaptic vesicle cycle_Homo sapiens_hsa047210.75403595
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75230271
66RNA polymerase_Homo sapiens_hsa030200.72616923
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71827279
68RNA transport_Homo sapiens_hsa030130.71367647
69Calcium signaling pathway_Homo sapiens_hsa040200.68772047
70Tryptophan metabolism_Homo sapiens_hsa003800.65033025
71Huntingtons disease_Homo sapiens_hsa050160.64491116
72Oxytocin signaling pathway_Homo sapiens_hsa049210.64253257
73Type II diabetes mellitus_Homo sapiens_hsa049300.62849918
74Gap junction_Homo sapiens_hsa045400.60812650
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60010114
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58491157
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57754207
78Caffeine metabolism_Homo sapiens_hsa002320.57385721
79Renin secretion_Homo sapiens_hsa049240.56204295
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55906886
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.55816119
82ABC transporters_Homo sapiens_hsa020100.54711706
83Ovarian steroidogenesis_Homo sapiens_hsa049130.51774413
84Collecting duct acid secretion_Homo sapiens_hsa049660.51147104
85Fatty acid metabolism_Homo sapiens_hsa012120.50590077
86Lysine degradation_Homo sapiens_hsa003100.49547460
87Tight junction_Homo sapiens_hsa045300.49192839
88Cell cycle_Homo sapiens_hsa041100.48230053
89TGF-beta signaling pathway_Homo sapiens_hsa043500.47336424
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.47012249
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45084207
92Nucleotide excision repair_Homo sapiens_hsa034200.43653481
93Alzheimers disease_Homo sapiens_hsa050100.42067218
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42016852
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41970763
96Ras signaling pathway_Homo sapiens_hsa040140.39726423
97Gastric acid secretion_Homo sapiens_hsa049710.39457813
98Salivary secretion_Homo sapiens_hsa049700.39149168
99Retinol metabolism_Homo sapiens_hsa008300.38824629
100p53 signaling pathway_Homo sapiens_hsa041150.38669298

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