ZNF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cornea development in camera-type eye (GO:0061303)4.87228600
2water-soluble vitamin biosynthetic process (GO:0042364)4.18756579
3behavioral response to nicotine (GO:0035095)4.02456117
4DNA deamination (GO:0045006)3.99718867
5response to pheromone (GO:0019236)3.72753857
6protein complex biogenesis (GO:0070271)3.69528590
7preassembly of GPI anchor in ER membrane (GO:0016254)3.60211824
8synapsis (GO:0007129)3.55149036
9protein polyglutamylation (GO:0018095)3.47772865
10mitochondrial respiratory chain complex assembly (GO:0033108)3.44501103
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37824708
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.37824708
13NADH dehydrogenase complex assembly (GO:0010257)3.37824708
14platelet dense granule organization (GO:0060155)3.37109865
15regulation of hexokinase activity (GO:1903299)3.32503946
16regulation of glucokinase activity (GO:0033131)3.32503946
17hindbrain development (GO:0030902)3.26478560
18respiratory chain complex IV assembly (GO:0008535)3.23464374
19piRNA metabolic process (GO:0034587)3.19622615
20kidney morphogenesis (GO:0060993)3.19393173
21negative regulation of telomere maintenance (GO:0032205)3.14203891
22L-fucose catabolic process (GO:0042355)3.13161381
23fucose catabolic process (GO:0019317)3.13161381
24L-fucose metabolic process (GO:0042354)3.13161381
25cilium morphogenesis (GO:0060271)3.11456874
26protein-cofactor linkage (GO:0018065)3.10890195
27photoreceptor cell development (GO:0042461)3.09734242
28epithelial cilium movement (GO:0003351)3.06004893
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.05975736
30cellular ketone body metabolic process (GO:0046950)3.05910599
31cytochrome complex assembly (GO:0017004)3.05704003
32mannosylation (GO:0097502)3.05288665
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05266088
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05266088
35gamma-aminobutyric acid transport (GO:0015812)3.03334200
36regulation of nuclear cell cycle DNA replication (GO:0033262)2.95736489
37ketone body metabolic process (GO:1902224)2.93983565
38protein K11-linked deubiquitination (GO:0035871)2.91986340
39regulation of timing of cell differentiation (GO:0048505)2.91918762
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88472000
41regulation of cilium movement (GO:0003352)2.86254507
42replication fork processing (GO:0031297)2.85570063
43neural tube formation (GO:0001841)2.85261471
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.81910874
45male meiosis I (GO:0007141)2.80922786
46signal peptide processing (GO:0006465)2.79589897
47somite development (GO:0061053)2.77472205
48eye photoreceptor cell development (GO:0042462)2.76709844
49axoneme assembly (GO:0035082)2.75912043
50C-terminal protein lipidation (GO:0006501)2.75696210
51intraciliary transport (GO:0042073)2.74431826
52cullin deneddylation (GO:0010388)2.72658193
53negative regulation of mast cell activation (GO:0033004)2.72338507
54GPI anchor metabolic process (GO:0006505)2.70311386
55magnesium ion transport (GO:0015693)2.68625357
56kynurenine metabolic process (GO:0070189)2.68461148
57DNA methylation involved in gamete generation (GO:0043046)2.68242745
58negative regulation of transcription regulatory region DNA binding (GO:2000678)2.68225509
59retinal cone cell development (GO:0046549)2.67871925
60recombinational repair (GO:0000725)2.65412639
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.64833119
62nonmotile primary cilium assembly (GO:0035058)2.64796947
63pituitary gland development (GO:0021983)2.64504589
64indole-containing compound catabolic process (GO:0042436)2.63689625
65indolalkylamine catabolic process (GO:0046218)2.63689625
66tryptophan catabolic process (GO:0006569)2.63689625
67pseudouridine synthesis (GO:0001522)2.63188121
68double-strand break repair via homologous recombination (GO:0000724)2.62611664
69multicellular organism reproduction (GO:0032504)2.61044857
70intracellular protein transmembrane import (GO:0044743)2.59711710
71protein prenylation (GO:0018342)2.59010471
72prenylation (GO:0097354)2.59010471
73embryonic epithelial tube formation (GO:0001838)2.58504295
74C-terminal protein amino acid modification (GO:0018410)2.58371897
75DNA double-strand break processing (GO:0000729)2.56489878
76indolalkylamine metabolic process (GO:0006586)2.55412722
77positive regulation of meiosis (GO:0045836)2.53837589
78detection of light stimulus involved in visual perception (GO:0050908)2.52732025
79detection of light stimulus involved in sensory perception (GO:0050962)2.52732025
80protein deneddylation (GO:0000338)2.52728588
81anterograde synaptic vesicle transport (GO:0048490)2.52567593
82positive regulation of oligodendrocyte differentiation (GO:0048714)2.52564256
83sulfation (GO:0051923)2.52317929
84spinal cord motor neuron differentiation (GO:0021522)2.52300493
85regulation of development, heterochronic (GO:0040034)2.51595724
86tRNA processing (GO:0008033)2.51583976
87reciprocal DNA recombination (GO:0035825)2.50135333
88reciprocal meiotic recombination (GO:0007131)2.50135333
89dorsal/ventral axis specification (GO:0009950)2.49910872
90signal transduction involved in regulation of gene expression (GO:0023019)2.49888358
91keratinocyte development (GO:0003334)2.49559837
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47491935
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.47233910
94negative regulation of DNA-dependent DNA replication (GO:2000104)2.46391590
95presynaptic membrane assembly (GO:0097105)2.46344036
96single strand break repair (GO:0000012)2.45685761
97cellular response to ATP (GO:0071318)2.45449907
98ubiquinone biosynthetic process (GO:0006744)2.44420313
99resolution of meiotic recombination intermediates (GO:0000712)2.43994113
100cilium organization (GO:0044782)2.43761075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.01272149
2VDR_22108803_ChIP-Seq_LS180_Human3.14940039
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.74954748
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68694667
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.64982520
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60277061
7* EST1_17652178_ChIP-ChIP_JURKAT_Human2.53067936
8GBX2_23144817_ChIP-Seq_PC3_Human2.48326407
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45110997
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39508764
11IGF1R_20145208_ChIP-Seq_DFB_Human2.35623890
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32019277
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.31589225
14EWS_26573619_Chip-Seq_HEK293_Human2.15554208
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.14146213
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09507783
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09431972
18FUS_26573619_Chip-Seq_HEK293_Human2.06576414
19P300_19829295_ChIP-Seq_ESCs_Human1.97415803
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95809832
21EZH2_22144423_ChIP-Seq_EOC_Human1.95402149
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86577936
23* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86039022
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.83173182
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81442411
26ER_23166858_ChIP-Seq_MCF-7_Human1.80258723
27VDR_23849224_ChIP-Seq_CD4+_Human1.72763361
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70913838
29MYC_18940864_ChIP-ChIP_HL60_Human1.70551670
30ELK1_19687146_ChIP-ChIP_HELA_Human1.69768631
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69500468
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68886516
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65128576
34TAF15_26573619_Chip-Seq_HEK293_Human1.57433325
35TP53_22573176_ChIP-Seq_HFKS_Human1.57103072
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54996188
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51892208
38IRF1_19129219_ChIP-ChIP_H3396_Human1.49475348
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48996747
40* ETS1_20019798_ChIP-Seq_JURKAT_Human1.48358007
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47463104
42SMAD4_21799915_ChIP-Seq_A2780_Human1.43025909
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.40374705
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40251700
45BCAT_22108803_ChIP-Seq_LS180_Human1.37473022
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34710662
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34399162
48* STAT3_23295773_ChIP-Seq_U87_Human1.34223517
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30682753
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.29873835
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28447849
52CBP_20019798_ChIP-Seq_JUKART_Human1.28447849
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26916658
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26669293
55FOXP3_21729870_ChIP-Seq_TREG_Human1.26126209
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25653102
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.25653102
58NANOG_19829295_ChIP-Seq_ESCs_Human1.25423782
59SOX2_19829295_ChIP-Seq_ESCs_Human1.25423782
60AR_25329375_ChIP-Seq_VCAP_Human1.25070950
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24885091
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24531046
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23604652
64* TCF4_23295773_ChIP-Seq_U87_Human1.23295627
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21906636
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.21487361
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.21350509
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21281207
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20766757
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20012195
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.19099195
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17837220
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17623534
74RNF2_27304074_Chip-Seq_NSC_Mouse1.16728590
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15618189
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14619189
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.14443006
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11476559
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10507447
80AR_20517297_ChIP-Seq_VCAP_Human1.10336212
81TCF4_22108803_ChIP-Seq_LS180_Human1.09960212
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09646678
83HTT_18923047_ChIP-ChIP_STHdh_Human1.09509973
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09204481
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.09096348
86AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07726074
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07244321
88P53_22387025_ChIP-Seq_ESCs_Mouse1.07235983
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06289423
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.05906593
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05564013
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05524178
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05524178
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05453288
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.04908649
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.04884505
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.03558992
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02872839
99NCOR_22424771_ChIP-Seq_293T_Human1.01897242
100RUNX2_22187159_ChIP-Seq_PCA_Human1.01853932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.44594850
2MP0008877_abnormal_DNA_methylation3.53419210
3MP0003195_calcinosis2.79402046
4MP0002102_abnormal_ear_morphology2.76525522
5MP0002938_white_spotting2.76219444
6MP0003787_abnormal_imprinting2.52171344
7MP0002638_abnormal_pupillary_reflex2.45641384
8MP0008789_abnormal_olfactory_epithelium2.32519298
9MP0006072_abnormal_retinal_apoptosis2.31601232
10MP0002837_dystrophic_cardiac_calcinosis2.27541030
11MP0005551_abnormal_eye_electrophysiolog2.04404096
12MP0000569_abnormal_digit_pigmentation1.97701398
13MP0005646_abnormal_pituitary_gland1.89212366
14MP0003646_muscle_fatigue1.88556678
15MP0008058_abnormal_DNA_repair1.87808205
16MP0009046_muscle_twitch1.82339059
17MP0001986_abnormal_taste_sensitivity1.80286848
18MP0003011_delayed_dark_adaptation1.79050300
19MP0005499_abnormal_olfactory_system1.67890952
20MP0005394_taste/olfaction_phenotype1.67890952
21MP0000631_abnormal_neuroendocrine_gland1.66375647
22MP0004133_heterotaxia1.62972559
23MP0005253_abnormal_eye_physiology1.62655899
24MP0001968_abnormal_touch/_nociception1.62247786
25MP0005379_endocrine/exocrine_gland_phen1.60576873
26MP0002160_abnormal_reproductive_system1.58531002
27MP0000427_abnormal_hair_cycle1.58339079
28MP0002163_abnormal_gland_morphology1.55110845
29MP0004142_abnormal_muscle_tone1.54190640
30MP0003121_genomic_imprinting1.52708169
31MP0000383_abnormal_hair_follicle1.51137243
32MP0005084_abnormal_gallbladder_morpholo1.49483739
33MP0002272_abnormal_nervous_system1.48690792
34MP0000372_irregular_coat_pigmentation1.47642752
35MP0002653_abnormal_ependyma_morphology1.43549948
36MP0005645_abnormal_hypothalamus_physiol1.42953207
37MP0002736_abnormal_nociception_after1.37696647
38MP0005075_abnormal_melanosome_morpholog1.35588559
39MP0003718_maternal_effect1.33749865
40MP0009745_abnormal_behavioral_response1.33044952
41MP0003122_maternal_imprinting1.32636796
42MP0008872_abnormal_physiological_respon1.30916034
43MP0005389_reproductive_system_phenotype1.28882701
44MP0004147_increased_porphyrin_level1.23814779
45MP0004885_abnormal_endolymph1.21511167
46MP0005257_abnormal_intraocular_pressure1.20975789
47MP0005174_abnormal_tail_pigmentation1.20814146
48MP0001984_abnormal_olfaction1.17603652
49MP0003890_abnormal_embryonic-extraembry1.17397312
50MP0003119_abnormal_digestive_system1.16107845
51MP0002876_abnormal_thyroid_physiology1.14881836
52MP0002751_abnormal_autonomic_nervous1.13388054
53MP0001501_abnormal_sleep_pattern1.12045742
54MP0002735_abnormal_chemical_nociception1.11963333
55MP0003937_abnormal_limbs/digits/tail_de1.09928213
56MP0002234_abnormal_pharynx_morphology1.09469002
57MP0001293_anophthalmia1.08761212
58MP0003880_abnormal_central_pattern1.08701747
59MP0001324_abnormal_eye_pigmentation1.06374043
60MP0000647_abnormal_sebaceous_gland1.06050839
61MP0002557_abnormal_social/conspecific_i1.05956651
62MP0003136_yellow_coat_color1.04568188
63MP0001485_abnormal_pinna_reflex1.03626992
64MP0001919_abnormal_reproductive_system1.03611283
65MP0000778_abnormal_nervous_system1.03421831
66MP0005410_abnormal_fertilization1.01085300
67MP0003137_abnormal_impulse_conducting1.00629818
68MP0008057_abnormal_DNA_replication1.00136768
69MP0000049_abnormal_middle_ear1.00021154
70MP0000613_abnormal_salivary_gland0.99875389
71MP0001486_abnormal_startle_reflex0.99616482
72MP0002095_abnormal_skin_pigmentation0.98328677
73MP0001944_abnormal_pancreas_morphology0.98178979
74MP0002138_abnormal_hepatobiliary_system0.96188386
75MP0005195_abnormal_posterior_eye0.95881777
76MP0002210_abnormal_sex_determination0.95040507
77MP0001929_abnormal_gametogenesis0.94996951
78MP0002277_abnormal_respiratory_mucosa0.94887586
79MP0005386_behavior/neurological_phenoty0.93467674
80MP0004924_abnormal_behavior0.93467674
81MP0005187_abnormal_penis_morphology0.92049270
82MP0001529_abnormal_vocalization0.92030532
83MP0010678_abnormal_skin_adnexa0.89677531
84MP0008995_early_reproductive_senescence0.89184036
85MP0002928_abnormal_bile_duct0.88420602
86MP0002693_abnormal_pancreas_physiology0.88381363
87MP0006276_abnormal_autonomic_nervous0.87386840
88MP0002282_abnormal_trachea_morphology0.86604920
89MP0002572_abnormal_emotion/affect_behav0.86029725
90MP0005391_vision/eye_phenotype0.85667403
91MP0000653_abnormal_sex_gland0.85555481
92MP0006036_abnormal_mitochondrial_physio0.84810946
93MP0000516_abnormal_urinary_system0.83395432
94MP0005367_renal/urinary_system_phenotyp0.83395432
95MP0003698_abnormal_male_reproductive0.83081178
96MP0002064_seizures0.81611185
97MP0003786_premature_aging0.80285081
98MP0004043_abnormal_pH_regulation0.80023142
99MP0002909_abnormal_adrenal_gland0.78990649
100MP0003283_abnormal_digestive_organ0.78989701

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.13245110
2Molar tooth sign on MRI (HP:0002419)3.75221311
3Abnormality of midbrain morphology (HP:0002418)3.75221311
4Pancreatic fibrosis (HP:0100732)3.70006249
5True hermaphroditism (HP:0010459)3.60411157
6Methylmalonic acidemia (HP:0002912)3.47854729
7Nephronophthisis (HP:0000090)3.39980595
8Pendular nystagmus (HP:0012043)3.38641014
9Aplasia/Hypoplasia of the fovea (HP:0008060)3.16546881
10Hypoplasia of the fovea (HP:0007750)3.16546881
11Congenital stationary night blindness (HP:0007642)3.16383317
12Methylmalonic aciduria (HP:0012120)3.03170698
13Abnormality of the renal medulla (HP:0100957)2.91274812
14Type II lissencephaly (HP:0007260)2.90650468
15Abnormality of the renal cortex (HP:0011035)2.85283195
16Acute necrotizing encephalopathy (HP:0006965)2.85268618
17Abnormality of the fovea (HP:0000493)2.72485725
18Absent rod-and cone-mediated responses on ERG (HP:0007688)2.69915321
19Abolished electroretinogram (ERG) (HP:0000550)2.65319424
20Abnormal rod and cone electroretinograms (HP:0008323)2.61983562
21Attenuation of retinal blood vessels (HP:0007843)2.56444689
22Progressive macrocephaly (HP:0004481)2.55618280
23Mitochondrial inheritance (HP:0001427)2.48698095
24Optic nerve hypoplasia (HP:0000609)2.48594729
25Increased CSF lactate (HP:0002490)2.48559343
26Increased corneal curvature (HP:0100692)2.45267496
27Keratoconus (HP:0000563)2.45267496
28Abnormal mitochondria in muscle tissue (HP:0008316)2.44690985
29Medial flaring of the eyebrow (HP:0010747)2.41710799
30Acute encephalopathy (HP:0006846)2.40000763
31Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.39577656
32Hyperventilation (HP:0002883)2.37820433
333-Methylglutaconic aciduria (HP:0003535)2.35857335
34Tubular atrophy (HP:0000092)2.35816576
35Cystic liver disease (HP:0006706)2.31807265
36Renal cortical cysts (HP:0000803)2.31547032
37Chronic hepatic failure (HP:0100626)2.29984104
38Lissencephaly (HP:0001339)2.24559142
39Intestinal atresia (HP:0011100)2.24385829
40Progressive inability to walk (HP:0002505)2.20366486
41Decreased central vision (HP:0007663)2.19715149
42Sclerocornea (HP:0000647)2.19704053
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.18493586
44Cerebellar dysplasia (HP:0007033)2.17356391
45Chorioretinal atrophy (HP:0000533)2.15966957
46Inability to walk (HP:0002540)2.15614590
47Abnormality of vitamin B metabolism (HP:0004340)2.15585625
48Aplasia/hypoplasia of the uterus (HP:0008684)2.15576620
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12368001
50Oligodactyly (hands) (HP:0001180)2.10218521
51Concave nail (HP:0001598)2.08038901
52Anencephaly (HP:0002323)2.07926590
53Neoplasm of the adrenal cortex (HP:0100641)2.07371254
54Hemiparesis (HP:0001269)2.06976737
55Furrowed tongue (HP:0000221)2.05945661
56Abnormal biliary tract physiology (HP:0012439)2.00471599
57Bile duct proliferation (HP:0001408)2.00471599
58Aplasia/Hypoplasia of the tibia (HP:0005772)2.00379049
59Large for gestational age (HP:0001520)1.99779739
60Abnormality of the labia minora (HP:0012880)1.98256246
61Optic disc pallor (HP:0000543)1.98035726
62Colon cancer (HP:0003003)1.95760454
63Abnormality of the vitamin B12 metabolism (HP:0004341)1.93942176
64Congenital hepatic fibrosis (HP:0002612)1.92812309
65Hepatic necrosis (HP:0002605)1.91589722
66Increased hepatocellular lipid droplets (HP:0006565)1.91309110
67Absent thumb (HP:0009777)1.91176614
68Hepatocellular necrosis (HP:0001404)1.89748036
69Postaxial foot polydactyly (HP:0001830)1.87532609
70Congenital, generalized hypertrichosis (HP:0004540)1.86503377
71Optic nerve coloboma (HP:0000588)1.86259114
72Polydipsia (HP:0001959)1.82600391
73Abnormal drinking behavior (HP:0030082)1.82600391
74Gait imbalance (HP:0002141)1.82239874
75Congenital primary aphakia (HP:0007707)1.81678939
76Male pseudohermaphroditism (HP:0000037)1.81514252
77Pachygyria (HP:0001302)1.81335374
78Lipid accumulation in hepatocytes (HP:0006561)1.79643546
79Aplasia/Hypoplasia of the uvula (HP:0010293)1.78186122
80Hypothermia (HP:0002045)1.77613722
81Aplasia/Hypoplasia of the sternum (HP:0006714)1.76424493
82Cerebral edema (HP:0002181)1.76229047
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74990776
84Abnormal protein N-linked glycosylation (HP:0012347)1.74990776
85Abnormal protein glycosylation (HP:0012346)1.74990776
86Abnormal glycosylation (HP:0012345)1.74990776
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74147347
88Abnormality of alanine metabolism (HP:0010916)1.74147347
89Hyperalaninemia (HP:0003348)1.74147347
90Gaze-evoked nystagmus (HP:0000640)1.72266702
91Hyperglycinemia (HP:0002154)1.72002615
92Nephrogenic diabetes insipidus (HP:0009806)1.69836279
93Severe muscular hypotonia (HP:0006829)1.69509733
94Birth length less than 3rd percentile (HP:0003561)1.69032761
95Aplasia/Hypoplasia of the macula (HP:0008059)1.68556790
96Aplasia/Hypoplasia of the patella (HP:0006498)1.68220595
97Preaxial hand polydactyly (HP:0001177)1.67739551
98Genetic anticipation (HP:0003743)1.67181505
99Retinal dysplasia (HP:0007973)1.66353268
100Short tibia (HP:0005736)1.66275128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.26354825
2BMPR1B3.50531741
3MAP4K23.33805568
4ACVR1B2.91116911
5WNK32.63195370
6ZAK2.56857905
7GRK12.49107269
8ADRBK22.40651028
9NUAK12.32491171
10MAPK132.18799517
11CASK2.14137226
12PINK12.09605288
13EIF2AK32.04864293
14TRIM281.92300291
15MKNK21.72867670
16INSRR1.51523100
17STK38L1.48448044
18PLK21.47554847
19BCKDK1.42461426
20MAP3K41.42159022
21PDK21.39897425
22TLK11.39059167
23CSNK1G31.36584663
24CSNK1G21.35890168
25CSNK1G11.34895452
26MST41.32451422
27OXSR11.31221812
28PTK2B1.25141006
29PBK1.22348108
30TAOK31.21174911
31TGFBR11.20944625
32WNK41.19930188
33STK391.19789124
34VRK21.18940591
35CSNK1A1L1.18217674
36EIF2AK11.14002617
37DYRK21.11618298
38WEE11.03238711
39PRKCE1.02607262
40MUSK1.01125233
41PAK30.99963927
42FGFR20.96004260
43VRK10.93506475
44DAPK20.93302278
45PLK30.92216378
46MAP2K70.89803843
47BRSK20.89108341
48NEK10.87699505
49ERBB30.86116454
50PRKCG0.85712404
51MKNK10.85481669
52PHKG20.84888734
53PHKG10.84888734
54SRPK10.81586955
55BCR0.81478240
56ADRBK10.79066600
57FER0.78224990
58NME10.76892967
59EPHA40.74141464
60BUB10.72004109
61MARK10.71613433
62TNIK0.68193366
63PRKCI0.66767180
64STK160.65100016
65MAP2K60.62813880
66CSNK1A10.62042624
67PLK10.60314686
68PLK40.59215629
69MAP3K120.54941823
70RPS6KA50.52412605
71CAMK2A0.50756852
72TXK0.48650916
73CAMKK20.48521739
74PASK0.46287964
75TIE10.46123287
76HIPK20.44511639
77STK30.44048767
78FLT30.42797477
79ATR0.41415270
80IKBKB0.40444547
81PRKACA0.40106967
82ATM0.39648949
83STK110.38562924
84DYRK30.37834582
85MAPKAPK30.37714142
86CSNK1D0.35854442
87CDK30.33298068
88EIF2AK20.33276838
89CHEK20.32191360
90CSNK2A10.31295108
91PAK60.31102784
92PRKAA10.30000104
93PRKCZ0.29006265
94PNCK0.28846315
95CHUK0.28844789
96CCNB10.27335134
97OBSCN0.27066716
98CAMK10.26728185
99PRKCQ0.25602056
100TTK0.23888045

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.38846886
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.17500066
3Protein export_Homo sapiens_hsa030602.80292100
4Oxidative phosphorylation_Homo sapiens_hsa001902.77523291
5Selenocompound metabolism_Homo sapiens_hsa004502.44908013
6RNA polymerase_Homo sapiens_hsa030202.44542423
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30227559
8Phototransduction_Homo sapiens_hsa047442.29091867
9Butanoate metabolism_Homo sapiens_hsa006502.23981620
10Homologous recombination_Homo sapiens_hsa034402.13354995
11Parkinsons disease_Homo sapiens_hsa050122.05432338
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04827097
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04217976
14Fanconi anemia pathway_Homo sapiens_hsa034602.04071044
15Basal transcription factors_Homo sapiens_hsa030222.03832442
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94530318
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86773205
18Proteasome_Homo sapiens_hsa030501.82788363
19Propanoate metabolism_Homo sapiens_hsa006401.81486585
20Nitrogen metabolism_Homo sapiens_hsa009101.73041132
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64416184
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59513278
23RNA degradation_Homo sapiens_hsa030181.58638397
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47385208
25Huntingtons disease_Homo sapiens_hsa050161.45550002
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44931428
27Steroid biosynthesis_Homo sapiens_hsa001001.44583025
28Peroxisome_Homo sapiens_hsa041461.41490713
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.41082847
30Collecting duct acid secretion_Homo sapiens_hsa049661.38560154
31Linoleic acid metabolism_Homo sapiens_hsa005911.35076142
32Alzheimers disease_Homo sapiens_hsa050101.33103752
33Tryptophan metabolism_Homo sapiens_hsa003801.31434723
34Nicotine addiction_Homo sapiens_hsa050331.28724902
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25422143
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23850548
37Non-homologous end-joining_Homo sapiens_hsa034501.22345544
38One carbon pool by folate_Homo sapiens_hsa006701.17191961
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16741368
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11194065
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11002068
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10596745
43Sulfur metabolism_Homo sapiens_hsa009201.06278490
44Nucleotide excision repair_Homo sapiens_hsa034201.01493830
45Pyrimidine metabolism_Homo sapiens_hsa002400.98828326
46Cardiac muscle contraction_Homo sapiens_hsa042600.98608597
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95123110
48Ether lipid metabolism_Homo sapiens_hsa005650.94606456
49Mismatch repair_Homo sapiens_hsa034300.93416898
50Regulation of autophagy_Homo sapiens_hsa041400.92309676
51RNA transport_Homo sapiens_hsa030130.89441779
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88992079
53Olfactory transduction_Homo sapiens_hsa047400.87950837
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.87811176
55Purine metabolism_Homo sapiens_hsa002300.87468358
56Taste transduction_Homo sapiens_hsa047420.86330279
57Base excision repair_Homo sapiens_hsa034100.85630176
58ABC transporters_Homo sapiens_hsa020100.79673389
59Fatty acid elongation_Homo sapiens_hsa000620.79231238
60Metabolic pathways_Homo sapiens_hsa011000.77568856
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75635628
62Caffeine metabolism_Homo sapiens_hsa002320.70069462
63Chemical carcinogenesis_Homo sapiens_hsa052040.69065873
64Insulin secretion_Homo sapiens_hsa049110.68328871
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.68027505
66beta-Alanine metabolism_Homo sapiens_hsa004100.62893876
67Folate biosynthesis_Homo sapiens_hsa007900.62318872
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61306355
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61211380
70Hedgehog signaling pathway_Homo sapiens_hsa043400.60025399
71Retinol metabolism_Homo sapiens_hsa008300.59914997
72GABAergic synapse_Homo sapiens_hsa047270.57996860
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57160532
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56416242
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55152331
76N-Glycan biosynthesis_Homo sapiens_hsa005100.52748615
77Circadian rhythm_Homo sapiens_hsa047100.52691724
78Glycerolipid metabolism_Homo sapiens_hsa005610.50656713
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48411405
80Vitamin digestion and absorption_Homo sapiens_hsa049770.47995910
81Ovarian steroidogenesis_Homo sapiens_hsa049130.47008052
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46801559
83Morphine addiction_Homo sapiens_hsa050320.46153406
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44877700
85Ribosome_Homo sapiens_hsa030100.42735646
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42072702
87Serotonergic synapse_Homo sapiens_hsa047260.41058379
88Circadian entrainment_Homo sapiens_hsa047130.40869172
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40759742
90Mineral absorption_Homo sapiens_hsa049780.38738539
91Glutathione metabolism_Homo sapiens_hsa004800.37067180
92Glutamatergic synapse_Homo sapiens_hsa047240.36658638
93Basal cell carcinoma_Homo sapiens_hsa052170.36617679
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35644228
95Arachidonic acid metabolism_Homo sapiens_hsa005900.34352718
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34297300
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.33644804
98p53 signaling pathway_Homo sapiens_hsa041150.33022207
99Fatty acid metabolism_Homo sapiens_hsa012120.32379057
100Fatty acid degradation_Homo sapiens_hsa000710.31716135

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