ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.86157759
2	epithelial cilium movement (GO:0003351)	4.61913479
3	behavioral response to nicotine (GO:0035095)	4.61453240
4	cilium movement (GO:0003341)	3.96983924
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.67815001
6	regulation of cilium movement (GO:0003352)	3.67333416
7	response to pheromone (GO:0019236)	3.66310155
8	intraciliary transport (GO:0042073)	3.60976916
9	nonmotile primary cilium assembly (GO:0035058)	3.53760416
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.51112661
11	NADH dehydrogenase complex assembly (GO:0010257)	3.51112661
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.51112661
13	axonemal dynein complex assembly (GO:0070286)	3.50543957
14	protein complex biogenesis (GO:0070271)	3.49268403
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.36470940
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.34944743
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.33105895
18	ATP synthesis coupled proton transport (GO:0015986)	3.33105895
19	axoneme assembly (GO:0035082)	3.31875541
20	protein-cofactor linkage (GO:0018065)	3.28534283
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.25998386
22	cilium morphogenesis (GO:0060271)	3.25820611
23	cilium or flagellum-dependent cell motility (GO:0001539)	3.25759002
24	platelet dense granule organization (GO:0060155)	3.24817354
25	protein localization to cilium (GO:0061512)	3.21577471
26	protein polyglutamylation (GO:0018095)	3.18653005
27	cilium organization (GO:0044782)	3.15556102
28	L-fucose catabolic process (GO:0042355)	3.15497356
29	fucose catabolic process (GO:0019317)	3.15497356
30	L-fucose metabolic process (GO:0042354)	3.15497356
31	centriole replication (GO:0007099)	3.15338706
32	pyrimidine nucleobase catabolic process (GO:0006208)	3.13138700
33	neural tube formation (GO:0001841)	3.13131915
34	negative regulation of telomere maintenance (GO:0032205)	3.10231917
35	respiratory chain complex IV assembly (GO:0008535)	3.09123051
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.06499654
37	cilium assembly (GO:0042384)	3.05895101
38	water-soluble vitamin biosynthetic process (GO:0042364)	3.05450286
39	somite development (GO:0061053)	3.02125455
40	indolalkylamine metabolic process (GO:0006586)	3.01054824
41	neuron fate determination (GO:0048664)	2.96327590
42	piRNA metabolic process (GO:0034587)	2.88849534
43	tryptophan catabolic process (GO:0006569)	2.88349434
44	indole-containing compound catabolic process (GO:0042436)	2.88349434
45	indolalkylamine catabolic process (GO:0046218)	2.88349434
46	kidney morphogenesis (GO:0060993)	2.84476536
47	DNA deamination (GO:0045006)	2.83439346
48	tryptophan metabolic process (GO:0006568)	2.83155028
49	kynurenine metabolic process (GO:0070189)	2.78834302
50	positive regulation of gastrulation (GO:2000543)	2.78153717
51	somite rostral/caudal axis specification (GO:0032525)	2.76924999
52	regulation of hexokinase activity (GO:1903299)	2.75457363
53	regulation of glucokinase activity (GO:0033131)	2.75457363
54	electron transport chain (GO:0022900)	2.74088265
55	microtubule depolymerization (GO:0007019)	2.73348391
56	regulation of microtubule-based movement (GO:0060632)	2.70830488
57	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.69448749
58	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.69448749
59	photoreceptor cell development (GO:0042461)	2.68074695
60	respiratory electron transport chain (GO:0022904)	2.67709171
61	presynaptic membrane assembly (GO:0097105)	2.67065478
62	negative regulation of mast cell activation (GO:0033004)	2.66883910
63	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.63677871
64	male meiosis I (GO:0007141)	2.63409224
65	cell proliferation in forebrain (GO:0021846)	2.62640560
66	preassembly of GPI anchor in ER membrane (GO:0016254)	2.62034807
67	DNA double-strand break processing (GO:0000729)	2.61561925
68	cytochrome complex assembly (GO:0017004)	2.60943984
69	mannosylation (GO:0097502)	2.60325970
70	limb bud formation (GO:0060174)	2.59875653
71	detection of light stimulus involved in visual perception (GO:0050908)	2.57447883
72	detection of light stimulus involved in sensory perception (GO:0050962)	2.57447883
73	sulfation (GO:0051923)	2.57357539
74	sequestering of actin monomers (GO:0042989)	2.56842732
75	GPI anchor metabolic process (GO:0006505)	2.56588262
76	nucleobase catabolic process (GO:0046113)	2.56144125
77	spinal cord motor neuron differentiation (GO:0021522)	2.55670476
78	gamma-aminobutyric acid transport (GO:0015812)	2.55561013
79	smoothened signaling pathway (GO:0007224)	2.53847463
80	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.51709594
81	retinal cone cell development (GO:0046549)	2.50483863
82	ubiquinone biosynthetic process (GO:0006744)	2.48936871
83	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.48157262
84	replication fork processing (GO:0031297)	2.47672739
85	synapsis (GO:0007129)	2.44845487
86	retinal ganglion cell axon guidance (GO:0031290)	2.44001266
87	reciprocal DNA recombination (GO:0035825)	2.43557152
88	reciprocal meiotic recombination (GO:0007131)	2.43557152
89	sperm motility (GO:0030317)	2.42673238
90	ubiquinone metabolic process (GO:0006743)	2.41669999
91	recombinational repair (GO:0000725)	2.41184290
92	base-excision repair, AP site formation (GO:0006285)	2.41016315
93	regulation of action potential (GO:0098900)	2.40297387
94	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.39144686
95	protein K11-linked deubiquitination (GO:0035871)	2.39131120
96	otic vesicle formation (GO:0030916)	2.38967285
97	behavioral response to ethanol (GO:0048149)	2.38876318
98	chaperone-mediated protein transport (GO:0072321)	2.38495335
99	intracellular protein transmembrane import (GO:0044743)	2.37349710
100	determination of left/right symmetry (GO:0007368)	2.36858450

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	4.01739996
2	VDR_22108803_ChIP-Seq_LS180_Human	3.00163740
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.76359750
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.64483637
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.53349947
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.51372355
7	FUS_26573619_Chip-Seq_HEK293_Human	2.43163171
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.38227444
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.37615712
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.37243545
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.34960404
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.29902985
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.27924397
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.27153376
15	EWS_26573619_Chip-Seq_HEK293_Human	2.26597105
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.24967245
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.20293122
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.18397086
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11760560
20	TAF15_26573619_Chip-Seq_HEK293_Human	2.10086419
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.02746034
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.98483541
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92268862
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.92129859
25	P300_19829295_ChIP-Seq_ESCs_Human	1.91922235
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.78282044
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.75100134
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.71856151
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.71235440
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67215160
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.66900958
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.63209050
33	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.62506858
34	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.60331103
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.58494615
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.55738842
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53059853
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.48559993
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.47771346
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.43601314
41	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43287644
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.43287644
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43179524
44	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.41360819
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.37139962
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37139962
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34694920
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33017581
49	AR_25329375_ChIP-Seq_VCAP_Human	1.32852983
50	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.31059027
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29325821
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29325821
53	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29042615
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28760818
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28760818
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28722692
57	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.25716752
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25350767
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24918398
60	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.24827403
61	BCAT_22108803_ChIP-Seq_LS180_Human	1.24685794
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.24589612
63	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22307077
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20948175
65	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20564219
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.19252916
67	STAT3_23295773_ChIP-Seq_U87_Human	1.16938907
68	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.14490558
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13710829
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.12359162
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11320097
72	TCF4_23295773_ChIP-Seq_U87_Human	1.10625451
73	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.10437005
74	NCOR_22424771_ChIP-Seq_293T_Human	1.09433815
75	AR_20517297_ChIP-Seq_VCAP_Human	1.08856758
76	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08825985
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07630052
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07039008
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06366883
80	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.06193501
81	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04875366
82	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04421363
83	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.04008366
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03702622
85	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03402403
86	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02490369
87	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.02128975
88	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.01778770
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99753121
90	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.99361081
91	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99184962
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98721788
93	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.96057571
94	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.95921288
95	AR_21572438_ChIP-Seq_LNCaP_Human	0.95665687
96	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95038966
97	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.93552065
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.91913100
99	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.90808641
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.90522762

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.19344068
2	MP0006292_abnormal_olfactory_placode	3.13723231
3	MP0008877_abnormal_DNA_methylation	2.67047827
4	MP0002102_abnormal_ear_morphology	2.63519545
5	MP0002653_abnormal_ependyma_morphology	2.54654247
6	MP0003880_abnormal_central_pattern	2.52417447
7	MP0000569_abnormal_digit_pigmentation	2.48591122
8	MP0006072_abnormal_retinal_apoptosis	2.28861302
9	MP0001529_abnormal_vocalization	2.23187239
10	MP0002638_abnormal_pupillary_reflex	2.20180036
11	MP0005551_abnormal_eye_electrophysiolog	2.16423494
12	MP0004133_heterotaxia	2.15163617
13	MP0002938_white_spotting	2.09150051
14	MP0008789_abnormal_olfactory_epithelium	1.94740722
15	MP0003195_calcinosis	1.90563986
16	MP0003890_abnormal_embryonic-extraembry	1.89195014
17	MP0000372_irregular_coat_pigmentation	1.87368829
18	MP0005253_abnormal_eye_physiology	1.84644842
19	MP0006276_abnormal_autonomic_nervous	1.79797285
20	MP0001968_abnormal_touch/_nociception	1.75185531
21	MP0005645_abnormal_hypothalamus_physiol	1.73197217
22	MP0002837_dystrophic_cardiac_calcinosis	1.72748177
23	MP0002736_abnormal_nociception_after	1.68670493
24	MP0000631_abnormal_neuroendocrine_gland	1.65745388
25	MP0002277_abnormal_respiratory_mucosa	1.64839989
26	MP0004142_abnormal_muscle_tone	1.63624323
27	MP0005084_abnormal_gallbladder_morpholo	1.62775920
28	MP0005394_taste/olfaction_phenotype	1.60383615
29	MP0005499_abnormal_olfactory_system	1.60383615
30	MP0003122_maternal_imprinting	1.57157425
31	MP0004885_abnormal_endolymph	1.53885027
32	MP0009046_muscle_twitch	1.52689979
33	MP0001986_abnormal_taste_sensitivity	1.52607279
34	MP0003787_abnormal_imprinting	1.52348232
35	MP0001485_abnormal_pinna_reflex	1.51292662
36	MP0005646_abnormal_pituitary_gland	1.48926510
37	MP0001984_abnormal_olfaction	1.48845099
38	MP0003011_delayed_dark_adaptation	1.47500348
39	MP0008058_abnormal_DNA_repair	1.46470667
40	MP0008995_early_reproductive_senescence	1.46466201
41	MP0001293_anophthalmia	1.46452258
42	MP0002234_abnormal_pharynx_morphology	1.42153027
43	MP0002735_abnormal_chemical_nociception	1.41039851
44	MP0000778_abnormal_nervous_system	1.41005654
45	MP0002822_catalepsy	1.39132303
46	MP0000566_synostosis	1.38744058
47	MP0004043_abnormal_pH_regulation	1.37618851
48	MP0002272_abnormal_nervous_system	1.37388363
49	MP0008872_abnormal_physiological_respon	1.35531860
50	MP0009745_abnormal_behavioral_response	1.33731041
51	MP0002095_abnormal_skin_pigmentation	1.31080298
52	MP0009379_abnormal_foot_pigmentation	1.28955237
53	MP0001486_abnormal_startle_reflex	1.25101226
54	MP0003121_genomic_imprinting	1.22323286
55	MP0002928_abnormal_bile_duct	1.21490808
56	MP0004147_increased_porphyrin_level	1.20288263
57	MP0005195_abnormal_posterior_eye	1.17287045
58	MP0005174_abnormal_tail_pigmentation	1.15945945
59	MP0003718_maternal_effect	1.15776064
60	MP0002557_abnormal_social/conspecific_i	1.15769240
61	MP0001324_abnormal_eye_pigmentation	1.14980130
62	MP0002572_abnormal_emotion/affect_behav	1.12948167
63	MP0000026_abnormal_inner_ear	1.08757470
64	MP0008875_abnormal_xenobiotic_pharmacok	1.08403392
65	MP0000049_abnormal_middle_ear	1.07579457
66	MP0005075_abnormal_melanosome_morpholog	1.04796067
67	MP0002067_abnormal_sensory_capabilities	1.04542083
68	MP0002751_abnormal_autonomic_nervous	1.04428529
69	MP0000647_abnormal_sebaceous_gland	1.02125980
70	MP0003937_abnormal_limbs/digits/tail_de	1.01499393
71	MP0005391_vision/eye_phenotype	1.00536179
72	MP0000427_abnormal_hair_cycle	0.98837945
73	MP0001905_abnormal_dopamine_level	0.98529728
74	MP0002160_abnormal_reproductive_system	0.98260534
75	MP0003119_abnormal_digestive_system	0.98079550
76	MP0002734_abnormal_mechanical_nocicepti	0.96286026
77	MP0001286_abnormal_eye_development	0.96048333
78	MP0002064_seizures	0.95904966
79	MP0002752_abnormal_somatic_nervous	0.95731966
80	MP0001929_abnormal_gametogenesis	0.95320550
81	MP0002282_abnormal_trachea_morphology	0.95299951
82	MP0003938_abnormal_ear_development	0.95120121
83	MP0003698_abnormal_male_reproductive	0.94856075
84	MP0005423_abnormal_somatic_nervous	0.93771335
85	MP0001970_abnormal_pain_threshold	0.92866611
86	MP0005389_reproductive_system_phenotype	0.92156137
87	MP0005386_behavior/neurological_phenoty	0.91734862
88	MP0004924_abnormal_behavior	0.91734862
89	MP0003878_abnormal_ear_physiology	0.91017536
90	MP0005377_hearing/vestibular/ear_phenot	0.91017536
91	MP0002210_abnormal_sex_determination	0.90610109
92	MP0002876_abnormal_thyroid_physiology	0.88713770
93	MP0000383_abnormal_hair_follicle	0.88288720
94	MP0004742_abnormal_vestibular_system	0.88045890
95	MP0002733_abnormal_thermal_nociception	0.87000116
96	MP0003646_muscle_fatigue	0.86311549
97	MP0005187_abnormal_penis_morphology	0.84489580
98	MP0001963_abnormal_hearing_physiology	0.83088320
99	MP0005410_abnormal_fertilization	0.81840474
100	MP0003567_abnormal_fetal_cardiomyocyte	0.81660393

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.26278687
2	True hermaphroditism (HP:0010459)	4.17624775
3	Pancreatic fibrosis (HP:0100732)	4.07789916
4	Abnormality of midbrain morphology (HP:0002418)	3.95998348
5	Molar tooth sign on MRI (HP:0002419)	3.95998348
6	Nephronophthisis (HP:0000090)	3.64696164
7	Medial flaring of the eyebrow (HP:0010747)	3.45239317
8	Congenital stationary night blindness (HP:0007642)	3.25505970
9	Abnormal respiratory motile cilium morphology (HP:0005938)	3.22654266
10	Abnormal respiratory epithelium morphology (HP:0012253)	3.22654266
11	Type II lissencephaly (HP:0007260)	3.13436465
12	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.04322117
13	Absent/shortened dynein arms (HP:0200106)	3.04322117
14	Abnormality of the renal medulla (HP:0100957)	3.01849691
15	Abnormal ciliary motility (HP:0012262)	2.98217374
16	Gait imbalance (HP:0002141)	2.94770204
17	Congenital primary aphakia (HP:0007707)	2.90047845
18	Chronic hepatic failure (HP:0100626)	2.75782447
19	Acute necrotizing encephalopathy (HP:0006965)	2.72372081
20	Cystic liver disease (HP:0006706)	2.68787439
21	Abnormal respiratory motile cilium physiology (HP:0012261)	2.65425005
22	Nephrogenic diabetes insipidus (HP:0009806)	2.65121654
23	Mitochondrial inheritance (HP:0001427)	2.62502672
24	Pendular nystagmus (HP:0012043)	2.62478639
25	Abnormality of the renal cortex (HP:0011035)	2.61337156
26	Anencephaly (HP:0002323)	2.58019684
27	Sclerocornea (HP:0000647)	2.54997856
28	Abolished electroretinogram (ERG) (HP:0000550)	2.48630638
29	Lipid accumulation in hepatocytes (HP:0006561)	2.44874248
30	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.44425685
31	Increased CSF lactate (HP:0002490)	2.42428297
32	Abnormal mitochondria in muscle tissue (HP:0008316)	2.42418239
33	Genital tract atresia (HP:0001827)	2.40915009
34	Increased hepatocellular lipid droplets (HP:0006565)	2.39724124
35	Vaginal atresia (HP:0000148)	2.38049955
36	Abnormal drinking behavior (HP:0030082)	2.36247500
37	Polydipsia (HP:0001959)	2.36247500
38	Abnormal number of erythroid precursors (HP:0012131)	2.35651266
39	Acute encephalopathy (HP:0006846)	2.34542693
40	Attenuation of retinal blood vessels (HP:0007843)	2.33720871
41	Colon cancer (HP:0003003)	2.31534347
42	Abnormality of the labia minora (HP:0012880)	2.30467256
43	Tubular atrophy (HP:0000092)	2.27678705
44	Septo-optic dysplasia (HP:0100842)	2.26053756
45	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.24903818
46	Progressive macrocephaly (HP:0004481)	2.24788279
47	Hyperventilation (HP:0002883)	2.23297057
48	Hepatocellular necrosis (HP:0001404)	2.23013535
49	Cerebellar dysplasia (HP:0007033)	2.22984735
50	Abnormality of alanine metabolism (HP:0010916)	2.22912366
51	Hyperalaninemia (HP:0003348)	2.22912366
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.22912366
53	Intestinal atresia (HP:0011100)	2.18229151
54	3-Methylglutaconic aciduria (HP:0003535)	2.18141992
55	Congenital, generalized hypertrichosis (HP:0004540)	2.17402831
56	Rhinitis (HP:0012384)	2.15964173
57	Optic nerve hypoplasia (HP:0000609)	2.15570340
58	Hepatic necrosis (HP:0002605)	2.13804238
59	Lissencephaly (HP:0001339)	2.13185169
60	Postaxial foot polydactyly (HP:0001830)	2.12527500
61	Male pseudohermaphroditism (HP:0000037)	2.10242809
62	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.09362670
63	Occipital encephalocele (HP:0002085)	2.07040330
64	Decreased central vision (HP:0007663)	2.06589769
65	Congenital hepatic fibrosis (HP:0002612)	2.04332346
66	Postaxial hand polydactyly (HP:0001162)	2.03727078
67	Abnormal rod and cone electroretinograms (HP:0008323)	2.03539461
68	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.03156156
69	Rib fusion (HP:0000902)	2.01655033
70	Inability to walk (HP:0002540)	2.01022122
71	Concave nail (HP:0001598)	1.97749222
72	Abnormality of cells of the erythroid lineage (HP:0012130)	1.96701594
73	Anophthalmia (HP:0000528)	1.95989958
74	Methylmalonic acidemia (HP:0002912)	1.95931630
75	Large for gestational age (HP:0001520)	1.95279248
76	Oligodactyly (hands) (HP:0001180)	1.95141785
77	Optic disc pallor (HP:0000543)	1.94046298
78	Polyuria (HP:0000103)	1.93051424
79	Renal cortical cysts (HP:0000803)	1.92321600
80	Poor coordination (HP:0002370)	1.91394114
81	Bile duct proliferation (HP:0001408)	1.89833467
82	Abnormal biliary tract physiology (HP:0012439)	1.89833467
83	Keratoconus (HP:0000563)	1.89210513
84	Increased corneal curvature (HP:0100692)	1.89210513
85	Hyperglycinemia (HP:0002154)	1.89099953
86	Renal Fanconi syndrome (HP:0001994)	1.87706534
87	Furrowed tongue (HP:0000221)	1.87497807
88	Short tibia (HP:0005736)	1.87038510
89	Abnormality of the pons (HP:0007361)	1.86359048
90	Polyphagia (HP:0002591)	1.85054215
91	Birth length less than 3rd percentile (HP:0003561)	1.81484075
92	Methylmalonic aciduria (HP:0012120)	1.81108372
93	Hypothermia (HP:0002045)	1.80967471
94	Preaxial hand polydactyly (HP:0001177)	1.80767205
95	Retinal dysplasia (HP:0007973)	1.80484692
96	Bilateral microphthalmos (HP:0007633)	1.80163604
97	Progressive cerebellar ataxia (HP:0002073)	1.78842622
98	Gastrointestinal atresia (HP:0002589)	1.78716818
99	Aplasia/Hypoplasia of the patella (HP:0006498)	1.77107500
100	Patellar aplasia (HP:0006443)	1.76381417

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	3.21328991
2	FRK	2.95419482
3	PNCK	2.90896826
4	WNK3	2.79404479
5	ZAK	2.77541279
6	MAP4K2	2.70168789
7	ADRBK2	2.44136333
8	WEE1	2.23425820
9	MAPK15	2.18556484
10	TLK1	2.13778011
11	MAP3K4	2.07571365
12	ACVR1B	1.96288336
13	GRK1	1.94435625
14	WNK4	1.91016946
15	NUAK1	1.87530598
16	VRK1	1.83449844
17	CASK	1.75784422
18	MAPK13	1.73999774
19	VRK2	1.73781530
20	INSRR	1.72797314
21	BRSK2	1.64898921
22	TRIM28	1.64738009
23	DYRK2	1.64468069
24	STK16	1.62561176
25	MKNK2	1.51183161
26	MAP2K7	1.48345878
27	BCKDK	1.39571659
28	PINK1	1.37124806
29	OXSR1	1.33486361
30	TAOK3	1.29020023
31	TGFBR1	1.23883213
32	TXK	1.18979771
33	MARK1	1.18256381
34	DYRK3	1.14806562
35	PLK4	1.13510932
36	MKNK1	1.11052679
37	CDK19	1.06649449
38	CAMKK2	1.06565045
39	PRKCG	1.04807093
40	NEK2	1.04362616
41	ADRBK1	1.00574835
42	STK39	1.00395448
43	DAPK2	0.99403007
44	BCR	0.97800935
45	EPHA3	0.95682723
46	CSNK1G2	0.90806696
47	PLK3	0.90514237
48	CSNK1G1	0.89042476
49	PAK3	0.86706193
50	CSNK1G3	0.86648150
51	PLK2	0.85209147
52	BUB1	0.84110862
53	NTRK2	0.83002545
54	TNIK	0.81551577
55	CCNB1	0.81475728
56	PRKCE	0.78119125
57	ERBB3	0.76893802
58	EPHA4	0.74937463
59	MAP2K4	0.73575162
60	RPS6KA5	0.72672848
61	NME1	0.70962317
62	TIE1	0.69209810
63	TSSK6	0.66186709
64	PKN1	0.65835834
65	EPHB2	0.63313652
66	SRPK1	0.62766756
67	FGFR2	0.61900978
68	PLK1	0.60855988
69	NEK1	0.60202472
70	CDC7	0.56721647
71	CSNK1A1L	0.56565538
72	PASK	0.54211188
73	ATR	0.51776141
74	DYRK1A	0.51625392
75	IRAK1	0.51609321
76	MAPKAPK5	0.51351670
77	TAF1	0.50707079
78	CDK3	0.47627520
79	PRKACA	0.45887920
80	CAMK2A	0.44910671
81	MAP3K12	0.44512384
82	PIK3CA	0.43865842
83	CHUK	0.42675330
84	CAMK1	0.42563885
85	PRKCI	0.42398573
86	CSNK1A1	0.37187072
87	PTK2B	0.36916663
88	BRSK1	0.36151226
89	GRK7	0.36130661
90	PRKCQ	0.35745466
91	DYRK1B	0.35593019
92	CHEK2	0.33344791
93	STK11	0.33276078
94	RPS6KA4	0.31927456
95	IKBKB	0.30473645
96	PRKG1	0.30055940
97	ATM	0.29577730
98	CSNK2A1	0.29368632
99	CSNK1D	0.28549633
100	AURKB	0.27549784

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.40956937
2	Parkinsons disease_Homo sapiens_hsa05012	2.79870754
3	Phototransduction_Homo sapiens_hsa04744	2.65889165
4	Ribosome_Homo sapiens_hsa03010	2.52018207
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.46804494
6	Protein export_Homo sapiens_hsa03060	2.37554663
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.28743671
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.27747161
9	RNA polymerase_Homo sapiens_hsa03020	2.18952388
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.17685867
11	Homologous recombination_Homo sapiens_hsa03440	2.12418814
12	Huntingtons disease_Homo sapiens_hsa05016	2.05023717
13	Butanoate metabolism_Homo sapiens_hsa00650	2.03791023
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.95262943
15	Nicotine addiction_Homo sapiens_hsa05033	1.95215590
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.95080453
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.92668062
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89061343
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.85399769
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.80494213
21	Basal transcription factors_Homo sapiens_hsa03022	1.77471454
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.68418792
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.66783198
24	Alzheimers disease_Homo sapiens_hsa05010	1.61490507
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.54376818
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.50401600
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.49289096
28	Propanoate metabolism_Homo sapiens_hsa00640	1.42057714
29	Proteasome_Homo sapiens_hsa03050	1.39799008
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.37340751
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.34292726
32	RNA degradation_Homo sapiens_hsa03018	1.27700921
33	Caffeine metabolism_Homo sapiens_hsa00232	1.26941811
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.24469876
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.22511827
36	Peroxisome_Homo sapiens_hsa04146	1.17724498
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.16308350
38	Olfactory transduction_Homo sapiens_hsa04740	1.14143316
39	Taste transduction_Homo sapiens_hsa04742	1.12061393
40	Steroid biosynthesis_Homo sapiens_hsa00100	1.09566417
41	Non-homologous end-joining_Homo sapiens_hsa03450	1.08002323
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.00931565
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99499559
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94932136
45	Morphine addiction_Homo sapiens_hsa05032	0.94513899
46	Mismatch repair_Homo sapiens_hsa03430	0.93216096
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.92724785
48	One carbon pool by folate_Homo sapiens_hsa00670	0.91788398
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90084574
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88318681
51	Base excision repair_Homo sapiens_hsa03410	0.88219972
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.87703850
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.85868730
54	Purine metabolism_Homo sapiens_hsa00230	0.85732006
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.85711806
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84716225
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81228670
58	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.80326017
59	GABAergic synapse_Homo sapiens_hsa04727	0.80285742
60	Retinol metabolism_Homo sapiens_hsa00830	0.79372451
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.78964625
62	Regulation of autophagy_Homo sapiens_hsa04140	0.76395516
63	Metabolic pathways_Homo sapiens_hsa01100	0.74687591
64	Serotonergic synapse_Homo sapiens_hsa04726	0.74512645
65	Sulfur relay system_Homo sapiens_hsa04122	0.73250978
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72248656
67	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.72161434
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.71518068
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70585953
70	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.69774988
71	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67929590
72	Spliceosome_Homo sapiens_hsa03040	0.59914420
73	ABC transporters_Homo sapiens_hsa02010	0.58524921
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.58360211
75	Circadian entrainment_Homo sapiens_hsa04713	0.57766909
76	RNA transport_Homo sapiens_hsa03013	0.57653616
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57014531
78	Asthma_Homo sapiens_hsa05310	0.56193303
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.54397425
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54387639
81	Cocaine addiction_Homo sapiens_hsa05030	0.53731428
82	Insulin secretion_Homo sapiens_hsa04911	0.50959969
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.50715663
84	Fatty acid degradation_Homo sapiens_hsa00071	0.49643102
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48198883
86	Fatty acid elongation_Homo sapiens_hsa00062	0.46221784
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45082870
88	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44730622
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.44409061
90	Histidine metabolism_Homo sapiens_hsa00340	0.43959355
91	Tyrosine metabolism_Homo sapiens_hsa00350	0.42108157
92	DNA replication_Homo sapiens_hsa03030	0.41785649
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41175205
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.37385744
95	Mineral absorption_Homo sapiens_hsa04978	0.35548659
96	Circadian rhythm_Homo sapiens_hsa04710	0.34219615
97	Salivary secretion_Homo sapiens_hsa04970	0.31844893
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.31832449
99	Glutathione metabolism_Homo sapiens_hsa00480	0.31292561
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.31256098

ZNF20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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