ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.77193373
2	piRNA metabolic process (GO:0034587)	4.61529396
3	tryptophan catabolic process (GO:0006569)	4.52791178
4	indole-containing compound catabolic process (GO:0042436)	4.52791178
5	indolalkylamine catabolic process (GO:0046218)	4.52791178
6	L-fucose catabolic process (GO:0042355)	4.42180560
7	fucose catabolic process (GO:0019317)	4.42180560
8	L-fucose metabolic process (GO:0042354)	4.42180560
9	NAD biosynthetic process (GO:0009435)	4.36419665
10	kynurenine metabolic process (GO:0070189)	4.30021379
11	indolalkylamine metabolic process (GO:0006586)	4.15159130
12	DNA deamination (GO:0045006)	3.91161708
13	tryptophan metabolic process (GO:0006568)	3.83449237
14	DNA methylation involved in gamete generation (GO:0043046)	3.80235615
15	regulation of meiosis I (GO:0060631)	3.78859623
16	multicellular organism reproduction (GO:0032504)	3.65324870
17	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.44058863
18	pyridine nucleotide biosynthetic process (GO:0019363)	3.44058863
19	detection of light stimulus involved in sensory perception (GO:0050962)	3.42553626
20	detection of light stimulus involved in visual perception (GO:0050908)	3.42553626
21	male meiosis I (GO:0007141)	3.32266077
22	protein K6-linked ubiquitination (GO:0085020)	3.27799514
23	cell wall macromolecule metabolic process (GO:0044036)	3.25762077
24	amine catabolic process (GO:0009310)	3.23575468
25	cellular biogenic amine catabolic process (GO:0042402)	3.23575468
26	retinal cone cell development (GO:0046549)	3.12902149
27	neural tube formation (GO:0001841)	3.08930599
28	cilium or flagellum-dependent cell motility (GO:0001539)	3.07721454
29	negative regulation of mast cell activation (GO:0033004)	3.04193264
30	protein K11-linked deubiquitination (GO:0035871)	3.02219387
31	response to pheromone (GO:0019236)	3.01379659
32	male meiosis (GO:0007140)	2.99926673
33	protein polyglutamylation (GO:0018095)	2.99439137
34	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.95903711
35	rRNA catabolic process (GO:0016075)	2.95672386
36	reciprocal DNA recombination (GO:0035825)	2.89917997
37	reciprocal meiotic recombination (GO:0007131)	2.89917997
38	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.88762200
39	meiotic chromosome segregation (GO:0045132)	2.87650196
40	regulation of female gonad development (GO:2000194)	2.86123008
41	sulfation (GO:0051923)	2.85738604
42	cellular response to ATP (GO:0071318)	2.83166065
43	indole-containing compound metabolic process (GO:0042430)	2.80798844
44	pseudouridine synthesis (GO:0001522)	2.77982767
45	interkinetic nuclear migration (GO:0022027)	2.76402553
46	DNA double-strand break processing (GO:0000729)	2.75462799
47	snRNA transcription (GO:0009301)	2.71617905
48	recombinational repair (GO:0000725)	2.68998906
49	double-strand break repair via homologous recombination (GO:0000724)	2.68324560
50	regulation of mitotic spindle checkpoint (GO:1903504)	2.67278232
51	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.67278232
52	benzene-containing compound metabolic process (GO:0042537)	2.65604853
53	behavioral response to ethanol (GO:0048149)	2.63625236
54	synapsis (GO:0007129)	2.61282785
55	cellular ketone body metabolic process (GO:0046950)	2.59280298
56	platelet dense granule organization (GO:0060155)	2.56161159
57	negative regulation of interleukin-1 beta production (GO:0032691)	2.54068772
58	positive regulation of meiosis (GO:0045836)	2.53636545
59	positive regulation of defense response to virus by host (GO:0002230)	2.53388043
60	DNA demethylation (GO:0080111)	2.52085719
61	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.50453467
62	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.50453467
63	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.48733141
64	signal peptide processing (GO:0006465)	2.48111649
65	gene silencing by RNA (GO:0031047)	2.47912257
66	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.47472193
67	meiosis I (GO:0007127)	2.46658546
68	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.45381596
69	meiotic cell cycle (GO:0051321)	2.44991677
70	rhodopsin mediated signaling pathway (GO:0016056)	2.44550338
71	negative regulation of telomere maintenance (GO:0032205)	2.43700246
72	negative regulation of interleukin-1 production (GO:0032692)	2.43375300
73	sperm motility (GO:0030317)	2.42354068
74	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.40049274
75	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.40049274
76	negative regulation of systemic arterial blood pressure (GO:0003085)	2.39043400
77	positive regulation of meiotic cell cycle (GO:0051446)	2.39006299
78	cellular response to exogenous dsRNA (GO:0071360)	2.38890886
79	regulation of hexokinase activity (GO:1903299)	2.36434365
80	regulation of glucokinase activity (GO:0033131)	2.36434365
81	single strand break repair (GO:0000012)	2.36084238
82	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.35923350
83	gonadal mesoderm development (GO:0007506)	2.34996688
84	protein K48-linked deubiquitination (GO:0071108)	2.33854681
85	regulation of defense response to virus by host (GO:0050691)	2.33057119
86	axoneme assembly (GO:0035082)	2.32312649
87	cAMP catabolic process (GO:0006198)	2.32205047
88	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.30664882
89	N-acetylglucosamine metabolic process (GO:0006044)	2.30623103
90	negative regulation of cAMP-mediated signaling (GO:0043951)	2.29652328
91	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.28650297
92	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.28650297
93	NADH dehydrogenase complex assembly (GO:0010257)	2.28650297
94	ketone body metabolic process (GO:1902224)	2.28594536
95	photoreceptor cell development (GO:0042461)	2.28453448
96	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.28063787
97	regulation of translation, ncRNA-mediated (GO:0045974)	2.28063787
98	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.28063787
99	regulation of acrosome reaction (GO:0060046)	2.27205497
100	adaptation of signaling pathway (GO:0023058)	2.26839168

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.95592345
2	VDR_22108803_ChIP-Seq_LS180_Human	2.85277943
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.75211176
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.75064074
5	* NOTCH1_21737748_ChIP-Seq_TLL_Human	2.64904771
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.61014975
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.54703602
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.20811909
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.19414262
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.14274529
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10278355
12	EWS_26573619_Chip-Seq_HEK293_Human	2.09270043
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.07499747
14	EZH2_22144423_ChIP-Seq_EOC_Human	2.07391662
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.00309270
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.98385153
17	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.98053432
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96632920
19	P300_19829295_ChIP-Seq_ESCs_Human	1.89431589
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.88678418
21	FUS_26573619_Chip-Seq_HEK293_Human	1.86766983
22	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.84756734
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.81998499
24	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79697652
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78543587
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.75033672
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.73639255
28	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.73392208
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.71350063
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.69122021
31	STAT3_23295773_ChIP-Seq_U87_Human	1.66571558
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64371443
33	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.58293493
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.57971640
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.56830672
36	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.51508220
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50144726
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.49771698
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48014604
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.48014604
41	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.47465063
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45620848
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.45620848
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38115017
45	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.37270746
46	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.36908526
47	GATA3_26560356_Chip-Seq_TH2_Human	1.35902703
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35735930
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35735930
50	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.35596258
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35492588
52	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.33885707
53	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.33332170
54	TCF4_23295773_ChIP-Seq_U87_Human	1.32070783
55	AR_25329375_ChIP-Seq_VCAP_Human	1.31968019
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31835430
57	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.31580837
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.31468097
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28736705
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28489330
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28489330
62	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25964448
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25684311
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25297248
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24346831
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22694500
67	VDR_23849224_ChIP-Seq_CD4+_Human	1.21071471
68	* AR_20517297_ChIP-Seq_VCAP_Human	1.20120969
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19890026
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.17194622
71	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.14898299
72	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.14865423
73	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.14510365
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14022474
75	NCOR_22424771_ChIP-Seq_293T_Human	1.13882541
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12616864
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12415816
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12066690
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11587994
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.10589701
81	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08692880
82	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08611891
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08412301
84	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08327038
85	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07742003
86	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.06452967
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06130905
88	SMRT_27268052_Chip-Seq_Bcells_Human	1.05017123
89	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.04796670
90	AR_21572438_ChIP-Seq_LNCaP_Human	1.03445243
91	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.02972091
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01548448
93	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98455240
94	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98209723
95	GATA3_26560356_Chip-Seq_TH1_Human	0.97956826
96	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97781364
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96986874
98	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96071208
99	CDX2_22108803_ChIP-Seq_LS180_Human	0.95741444
100	ELK1_19687146_ChIP-ChIP_HELA_Human	0.95550828

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.73383009
2	MP0008877_abnormal_DNA_methylation	3.31643000
3	MP0003646_muscle_fatigue	3.28103845
4	MP0003195_calcinosis	3.16324260
5	MP0002102_abnormal_ear_morphology	2.44192614
6	MP0003718_maternal_effect	2.25440445
7	MP0003724_increased_susceptibility_to	2.20272386
8	MP0005551_abnormal_eye_electrophysiolog	2.16887820
9	MP0005174_abnormal_tail_pigmentation	2.16757950
10	MP0001485_abnormal_pinna_reflex	2.08550473
11	MP0009046_muscle_twitch	1.97558360
12	MP0005410_abnormal_fertilization	1.85351133
13	MP0002277_abnormal_respiratory_mucosa	1.76972689
14	MP0000372_irregular_coat_pigmentation	1.74397775
15	MP0002138_abnormal_hepatobiliary_system	1.73797643
16	MP0001968_abnormal_touch/_nociception	1.69991491
17	MP0005253_abnormal_eye_physiology	1.67815039
18	MP0006292_abnormal_olfactory_placode	1.65278250
19	MP0000427_abnormal_hair_cycle	1.64269861
20	MP0002837_dystrophic_cardiac_calcinosis	1.62025274
21	MP0003136_yellow_coat_color	1.56445645
22	MP0008872_abnormal_physiological_respon	1.55337330
23	MP0001501_abnormal_sleep_pattern	1.53413679
24	MP0008875_abnormal_xenobiotic_pharmacok	1.52128668
25	MP0008057_abnormal_DNA_replication	1.51859545
26	MP0006072_abnormal_retinal_apoptosis	1.51711825
27	MP0005671_abnormal_response_to	1.50587884
28	MP0008058_abnormal_DNA_repair	1.49241261
29	MP0001986_abnormal_taste_sensitivity	1.47039119
30	MP0001929_abnormal_gametogenesis	1.46876592
31	MP0000015_abnormal_ear_pigmentation	1.45088510
32	MP0002735_abnormal_chemical_nociception	1.42050143
33	MP0003878_abnormal_ear_physiology	1.39496990
34	MP0005377_hearing/vestibular/ear_phenot	1.39496990
35	MP0000685_abnormal_immune_system	1.39488382
36	MP0008995_early_reproductive_senescence	1.38279967
37	MP0001800_abnormal_humoral_immune	1.37745265
38	MP0002736_abnormal_nociception_after	1.33945910
39	MP0005075_abnormal_melanosome_morpholog	1.33699770
40	MP0000383_abnormal_hair_follicle	1.32045123
41	MP0004742_abnormal_vestibular_system	1.29243989
42	MP0009764_decreased_sensitivity_to	1.25007908
43	MP0003693_abnormal_embryo_hatching	1.23411001
44	MP0003698_abnormal_male_reproductive	1.22006007
45	MP0003950_abnormal_plasma_membrane	1.20692649
46	MP0002148_abnormal_hypersensitivity_rea	1.18938800
47	MP0009785_altered_susceptibility_to	1.18540635
48	MP0004142_abnormal_muscle_tone	1.17996929
49	MP0002095_abnormal_skin_pigmentation	1.17706705
50	MP0002210_abnormal_sex_determination	1.16614348
51	MP0005646_abnormal_pituitary_gland	1.15171541
52	MP0005645_abnormal_hypothalamus_physiol	1.14231921
53	MP0001919_abnormal_reproductive_system	1.14081298
54	MP0005389_reproductive_system_phenotype	1.13176755
55	MP0009745_abnormal_behavioral_response	1.12437892
56	MP0000631_abnormal_neuroendocrine_gland	1.11287850
57	MP0002723_abnormal_immune_serum	1.08570274
58	MP0005167_abnormal_blood-brain_barrier	1.06811215
59	MP0006082_CNS_inflammation	1.04499047
60	MP0004043_abnormal_pH_regulation	1.02725476
61	MP0001873_stomach_inflammation	1.00211242
62	MP0001790_abnormal_immune_system	1.00047794
63	MP0005387_immune_system_phenotype	1.00047794
64	MP0000653_abnormal_sex_gland	0.98839111
65	MP0006276_abnormal_autonomic_nervous	0.98349896
66	MP0002452_abnormal_antigen_presenting	0.97389182
67	MP0005083_abnormal_biliary_tract	0.96498820
68	MP0005310_abnormal_salivary_gland	0.96130894
69	MP0002234_abnormal_pharynx_morphology	0.95710972
70	MP0001486_abnormal_startle_reflex	0.93905474
71	MP0000470_abnormal_stomach_morphology	0.92939848
72	MP0005395_other_phenotype	0.92384561
73	MP0010094_abnormal_chromosome_stability	0.92052513
74	MP0001145_abnormal_male_reproductive	0.91523711
75	MP0002928_abnormal_bile_duct	0.89514766
76	MP0002160_abnormal_reproductive_system	0.88521628
77	MP0002272_abnormal_nervous_system	0.88147959
78	MP0004147_increased_porphyrin_level	0.88132048
79	MP0000371_diluted_coat_color	0.87728037
80	MP0005266_abnormal_metabolism	0.87086511
81	MP0002693_abnormal_pancreas_physiology	0.87051819
82	MP0002420_abnormal_adaptive_immunity	0.86536362
83	MP0001819_abnormal_immune_cell	0.86228620
84	MP0004381_abnormal_hair_follicle	0.86183827
85	MP0004885_abnormal_endolymph	0.85379755
86	MP0005000_abnormal_immune_tolerance	0.83313452
87	MP0001835_abnormal_antigen_presentation	0.83265476
88	MP0002638_abnormal_pupillary_reflex	0.80213048
89	MP0001119_abnormal_female_reproductive	0.78290988
90	MP0001293_anophthalmia	0.77662192
91	MP0002733_abnormal_thermal_nociception	0.76539914
92	MP0002067_abnormal_sensory_capabilities	0.75743800
93	MP0001324_abnormal_eye_pigmentation	0.75523289
94	MP0003567_abnormal_fetal_cardiomyocyte	0.74118385
95	MP0005195_abnormal_posterior_eye	0.73990194
96	MP0002254_reproductive_system_inflammat	0.73838710
97	MP0008961_abnormal_basal_metabolism	0.73274890
98	MP0002405_respiratory_system_inflammati	0.72181993
99	MP0001970_abnormal_pain_threshold	0.71792104
100	MP0003890_abnormal_embryonic-extraembry	0.71751745

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.64687669
2	Attenuation of retinal blood vessels (HP:0007843)	4.44018311
3	Pancreatic fibrosis (HP:0100732)	4.14808479
4	Molar tooth sign on MRI (HP:0002419)	4.06954732
5	Abnormality of midbrain morphology (HP:0002418)	4.06954732
6	Congenital stationary night blindness (HP:0007642)	3.99483149
7	True hermaphroditism (HP:0010459)	3.90762975
8	Nephronophthisis (HP:0000090)	3.37596027
9	Genetic anticipation (HP:0003743)	3.20479598
10	Abnormality of the renal cortex (HP:0011035)	3.10425850
11	Birth length less than 3rd percentile (HP:0003561)	2.99312267
12	Abnormality of the renal medulla (HP:0100957)	2.91677226
13	Cystic liver disease (HP:0006706)	2.89557588
14	Progressive cerebellar ataxia (HP:0002073)	2.80141474
15	Pendular nystagmus (HP:0012043)	2.70758742
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.69621204
17	Chronic hepatic failure (HP:0100626)	2.69243078
18	Stomatitis (HP:0010280)	2.69059218
19	Bile duct proliferation (HP:0001408)	2.57249325
20	Abnormal biliary tract physiology (HP:0012439)	2.57249325
21	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.54413897
22	Concave nail (HP:0001598)	2.52677022
23	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.52589545
24	Abnormality of alanine metabolism (HP:0010916)	2.52589545
25	Hyperalaninemia (HP:0003348)	2.52589545
26	Abolished electroretinogram (ERG) (HP:0000550)	2.52227332
27	Renal cortical cysts (HP:0000803)	2.49068664
28	Type II lissencephaly (HP:0007260)	2.48639172
29	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.48434368
30	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.47001289
31	Progressive inability to walk (HP:0002505)	2.46386344
32	Furrowed tongue (HP:0000221)	2.43226950
33	Chromsome breakage (HP:0040012)	2.41029524
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.39993238
35	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.39146910
36	Inability to walk (HP:0002540)	2.38336106
37	Congenital sensorineural hearing impairment (HP:0008527)	2.37478094
38	Fair hair (HP:0002286)	2.37346570
39	Anencephaly (HP:0002323)	2.34233326
40	Gaze-evoked nystagmus (HP:0000640)	2.32369904
41	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.29012979
42	Absent/shortened dynein arms (HP:0200106)	2.29012979
43	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.27957746
44	Patellar aplasia (HP:0006443)	2.26933937
45	Abnormality of the renal collecting system (HP:0004742)	2.23672530
46	3-Methylglutaconic aciduria (HP:0003535)	2.23213339
47	Generalized hypopigmentation of hair (HP:0011358)	2.23002747
48	Hyperventilation (HP:0002883)	2.22999686
49	Decreased central vision (HP:0007663)	2.21162000
50	Aplasia/Hypoplasia of the patella (HP:0006498)	2.16820197
51	Oligodactyly (hands) (HP:0001180)	2.16743179
52	Cerebellar dysplasia (HP:0007033)	2.15648879
53	Ectopic kidney (HP:0000086)	2.13295729
54	Abnormality of chromosome stability (HP:0003220)	2.11660587
55	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.11442026
56	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.10845308
57	Congenital hepatic fibrosis (HP:0002612)	2.10683936
58	Tubular atrophy (HP:0000092)	2.10081794
59	Duplicated collecting system (HP:0000081)	2.09615733
60	Clubbing of toes (HP:0100760)	2.08563052
61	Clumsiness (HP:0002312)	2.06693077
62	Medial flaring of the eyebrow (HP:0010747)	2.05561816
63	Sclerocornea (HP:0000647)	2.04194793
64	Polydipsia (HP:0001959)	2.02993460
65	Abnormal drinking behavior (HP:0030082)	2.02993460
66	Keratoconus (HP:0000563)	2.02654244
67	Increased corneal curvature (HP:0100692)	2.02654244
68	Partial agenesis of the corpus callosum (HP:0001338)	2.00976092
69	Abnormality of DNA repair (HP:0003254)	2.00204294
70	Hypoplasia of the fovea (HP:0007750)	1.99967207
71	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.99967207
72	Stomach cancer (HP:0012126)	1.99606457
73	Bony spicule pigmentary retinopathy (HP:0007737)	1.99525947
74	Abnormality of the pons (HP:0007361)	1.98566874
75	Supernumerary spleens (HP:0009799)	1.98373910
76	Constricted visual fields (HP:0001133)	1.93620671
77	Hypoplasia of the pons (HP:0012110)	1.93501900
78	Severe muscular hypotonia (HP:0006829)	1.93155232
79	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.92435009
80	Febrile seizures (HP:0002373)	1.92234605
81	Meckel diverticulum (HP:0002245)	1.91239547
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.90784037
83	Optic neuritis (HP:0100653)	1.90307583
84	Retrobulbar optic neuritis (HP:0100654)	1.90307583
85	Abnormality of the ileum (HP:0001549)	1.89755882
86	Male pseudohermaphroditism (HP:0000037)	1.89362633
87	Protruding tongue (HP:0010808)	1.88900771
88	Postaxial foot polydactyly (HP:0001830)	1.87991998
89	Sloping forehead (HP:0000340)	1.86688610
90	Short tibia (HP:0005736)	1.81238778
91	Photophobia (HP:0000613)	1.75832855
92	Decreased circulating renin level (HP:0003351)	1.75028117
93	Recurrent cutaneous fungal infections (HP:0011370)	1.74118547
94	Chronic mucocutaneous candidiasis (HP:0002728)	1.74118547
95	Congenital, generalized hypertrichosis (HP:0004540)	1.73955670
96	Preaxial hand polydactyly (HP:0001177)	1.73953669
97	Optic disc pallor (HP:0000543)	1.70758592
98	Severe visual impairment (HP:0001141)	1.69753644
99	Abnormality of the preputium (HP:0100587)	1.69560332
100	Oligohydramnios (HP:0001562)	1.69496722

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.90002915
2	INSRR	5.59576558
3	ADRBK2	3.71437434
4	ACVR1B	3.62536629
5	ZAK	3.00710928
6	BMPR1B	2.96350138
7	GRK1	2.83028954
8	TAOK3	2.64449692
9	PINK1	2.60894579
10	NUAK1	2.27495446
11	MAP4K2	2.09123997
12	WNK3	1.92940470
13	TLK1	1.89478743
14	TXK	1.49394195
15	MAP3K4	1.38114521
16	OXSR1	1.30959609
17	BRSK2	1.30834664
18	TRIM28	1.25013561
19	MAPK13	1.22012742
20	ADRBK1	1.21672592
21	WNK4	1.19105939
22	IKBKB	1.14340613
23	EIF2AK3	1.03678747
24	PTK2B	1.02400944
25	PLK4	0.94784739
26	DAPK2	0.94456180
27	STK38L	0.93480821
28	IKBKE	0.93089851
29	STK39	0.91206104
30	CHUK	0.88739954
31	PIM1	0.87798754
32	NTRK3	0.87438115
33	STK3	0.84454319
34	IRAK4	0.81301474
35	MARK3	0.79605712
36	IRAK1	0.74477478
37	SYK	0.74400855
38	MAP4K1	0.73263371
39	TEC	0.72015692
40	TGFBR1	0.71889265
41	PRKCQ	0.70227617
42	PAK3	0.68677103
43	DYRK3	0.68378194
44	LATS1	0.66357923
45	CAMKK2	0.66002731
46	MKNK2	0.65453729
47	PIK3CG	0.64635188
48	GRK7	0.64254859
49	TNK2	0.63166833
50	CHEK2	0.62551811
51	RPS6KA5	0.59998052
52	KIT	0.56691132
53	TNIK	0.56428387
54	ITK	0.56078059
55	WEE1	0.55570507
56	MAP2K1	0.55336774
57	SIK2	0.55066913
58	LYN	0.54908074
59	GRK6	0.54374001
60	JAK3	0.53123646
61	PRKAA2	0.52590716
62	AKT3	0.52067663
63	DYRK2	0.51028955
64	NEK2	0.50800209
65	PLK1	0.49224497
66	PRKCE	0.48825429
67	VRK1	0.48525928
68	RAF1	0.46966073
69	MAP3K14	0.45851401
70	PRKCG	0.45381795
71	LCK	0.44456765
72	MAP3K2	0.44268572
73	PLK2	0.43838851
74	KSR1	0.42728563
75	MATK	0.41691874
76	ATR	0.40204303
77	CSNK1D	0.38892986
78	BLK	0.38590762
79	NLK	0.38045490
80	MELK	0.37748092
81	MAP2K7	0.37649343
82	TBK1	0.36129194
83	PKN1	0.35036030
84	CSNK1G1	0.34757662
85	BUB1	0.33092582
86	BTK	0.32982516
87	MAPKAPK5	0.32969851
88	CSNK1A1L	0.32386225
89	HCK	0.32360546
90	CSNK1G2	0.31359993
91	PRKCZ	0.31287646
92	BCKDK	0.31236887
93	MUSK	0.30863040
94	ATM	0.29662600
95	PRKCI	0.29217416
96	CASK	0.28263784
97	PRKACB	0.27528033
98	DYRK1A	0.27011844
99	ERBB3	0.26876865
100	PRKACA	0.26423581

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.92811044
2	Phototransduction_Homo sapiens_hsa04744	3.00493333
3	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.81348794
4	Homologous recombination_Homo sapiens_hsa03440	2.64316383
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.34963176
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.29642687
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.18855830
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.10967264
9	Nitrogen metabolism_Homo sapiens_hsa00910	1.98222388
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.97741149
11	Primary immunodeficiency_Homo sapiens_hsa05340	1.93736159
12	Butanoate metabolism_Homo sapiens_hsa00650	1.87886621
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.86070755
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82845731
15	RNA polymerase_Homo sapiens_hsa03020	1.75621351
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.74181874
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.67209767
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.63487068
19	Basal transcription factors_Homo sapiens_hsa03022	1.60684002
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.57574281
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.54365595
22	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.51535852
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.46155316
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.45159397
25	Caffeine metabolism_Homo sapiens_hsa00232	1.44423248
26	ABC transporters_Homo sapiens_hsa02010	1.42807068
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.42047709
28	Taste transduction_Homo sapiens_hsa04742	1.41051282
29	Nicotine addiction_Homo sapiens_hsa05033	1.41000204
30	Olfactory transduction_Homo sapiens_hsa04740	1.40623599
31	Graft-versus-host disease_Homo sapiens_hsa05332	1.32813671
32	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.30987673
33	Regulation of autophagy_Homo sapiens_hsa04140	1.30062087
34	RNA degradation_Homo sapiens_hsa03018	1.27657058
35	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.26065214
36	One carbon pool by folate_Homo sapiens_hsa00670	1.14228040
37	Morphine addiction_Homo sapiens_hsa05032	1.11186534
38	Allograft rejection_Homo sapiens_hsa05330	1.07395947
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.02521568
40	Type I diabetes mellitus_Homo sapiens_hsa04940	0.97179040
41	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.96429530
42	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.95663664
43	Non-homologous end-joining_Homo sapiens_hsa03450	0.92847012
44	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.92669912
45	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.91250330
46	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89791619
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.89734530
48	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.89118906
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87568850
50	Serotonergic synapse_Homo sapiens_hsa04726	0.85453510
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.85125097
52	Asthma_Homo sapiens_hsa05310	0.79159142
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78567712
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.77048565
55	Oxidative phosphorylation_Homo sapiens_hsa00190	0.76393376
56	Peroxisome_Homo sapiens_hsa04146	0.75172170
57	Protein export_Homo sapiens_hsa03060	0.74847650
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73126005
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71092566
60	Purine metabolism_Homo sapiens_hsa00230	0.69784762
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67262559
62	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.64671153
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62405648
64	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.62398242
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.61212377
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60667797
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.59939877
68	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.59716944
69	Parkinsons disease_Homo sapiens_hsa05012	0.56405522
70	Base excision repair_Homo sapiens_hsa03410	0.55105775
71	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.53418930
72	GABAergic synapse_Homo sapiens_hsa04727	0.53356838
73	Mismatch repair_Homo sapiens_hsa03430	0.52897936
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.52739802
75	RNA transport_Homo sapiens_hsa03013	0.52462648
76	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.51230627
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.49786493
78	Herpes simplex infection_Homo sapiens_hsa05168	0.48762040
79	Histidine metabolism_Homo sapiens_hsa00340	0.46733984
80	Antigen processing and presentation_Homo sapiens_hsa04612	0.46492160
81	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.45622034
82	Circadian entrainment_Homo sapiens_hsa04713	0.45025158
83	Retinol metabolism_Homo sapiens_hsa00830	0.44660608
84	Rheumatoid arthritis_Homo sapiens_hsa05323	0.44260508
85	Propanoate metabolism_Homo sapiens_hsa00640	0.42899248
86	Cell cycle_Homo sapiens_hsa04110	0.42543009
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.41944699
88	Huntingtons disease_Homo sapiens_hsa05016	0.39589739
89	Legionellosis_Homo sapiens_hsa05134	0.39424609
90	TNF signaling pathway_Homo sapiens_hsa04668	0.39268238
91	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.39249828
92	African trypanosomiasis_Homo sapiens_hsa05143	0.38958329
93	Type II diabetes mellitus_Homo sapiens_hsa04930	0.38954859
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.38199832
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.37811038
96	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.37311014
97	Tuberculosis_Homo sapiens_hsa05152	0.36258982
98	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.36231897
99	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.35969093
100	Malaria_Homo sapiens_hsa05144	0.34992386

ZNF200

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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