ZNF207

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.53020804
2nuclear pore organization (GO:0006999)6.28223277
3mitotic sister chromatid cohesion (GO:0007064)5.00096136
4pore complex assembly (GO:0046931)4.79041800
5* sister chromatid segregation (GO:0000819)4.48915574
6mitotic nuclear envelope disassembly (GO:0007077)4.28191999
7monoubiquitinated protein deubiquitination (GO:0035520)4.26394071
8DNA unwinding involved in DNA replication (GO:0006268)4.14773632
9protein localization to kinetochore (GO:0034501)4.12185263
10nuclear envelope disassembly (GO:0051081)4.10888691
11membrane disassembly (GO:0030397)4.10888691
12* mitotic sister chromatid segregation (GO:0000070)4.10504779
13DNA replication checkpoint (GO:0000076)4.04669085
14regulation of DNA endoreduplication (GO:0032875)4.03505762
15regulation of centriole replication (GO:0046599)3.95082478
16DNA topological change (GO:0006265)3.90848898
17double-strand break repair via nonhomologous end joining (GO:0006303)3.86959640
18non-recombinational repair (GO:0000726)3.86959640
19protein localization to chromosome, centromeric region (GO:0071459)3.75766697
20chromatin remodeling at centromere (GO:0031055)3.74485122
21DNA strand elongation involved in DNA replication (GO:0006271)3.71630077
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.69597541
23CENP-A containing nucleosome assembly (GO:0034080)3.67265359
24DNA geometric change (GO:0032392)3.63225537
25DNA duplex unwinding (GO:0032508)3.60193912
26DNA double-strand break processing (GO:0000729)3.56483523
27ribosome assembly (GO:0042255)3.55081314
28DNA strand elongation (GO:0022616)3.54060556
29DNA replication initiation (GO:0006270)3.50209234
30mitotic recombination (GO:0006312)3.45736781
31replication fork processing (GO:0031297)3.45711068
32kinetochore organization (GO:0051383)3.44645674
33mitotic chromosome condensation (GO:0007076)3.42569562
34* spindle checkpoint (GO:0031577)3.42395333
35pre-miRNA processing (GO:0031054)3.40090921
36positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.39409778
37positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.39409778
38positive regulation of mitotic sister chromatid separation (GO:1901970)3.39409778
39mitotic metaphase plate congression (GO:0007080)3.39065010
40* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.35759534
41* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.35759534
42* negative regulation of chromosome segregation (GO:0051985)3.34076366
43negative regulation of mRNA processing (GO:0050686)3.32350893
44positive regulation of histone H3-K4 methylation (GO:0051571)3.31457595
45negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31391214
46regulation of RNA export from nucleus (GO:0046831)3.31195726
47* mitotic spindle checkpoint (GO:0071174)3.30648925
48* regulation of mitotic sister chromatid separation (GO:0010965)3.30573527
49* regulation of mitotic sister chromatid segregation (GO:0033047)3.30573527
50* regulation of sister chromatid segregation (GO:0033045)3.30573527
51* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.30123164
52* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.30123164
53* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.30123164
54* negative regulation of mitotic sister chromatid separation (GO:2000816)3.30123164
55* negative regulation of sister chromatid segregation (GO:0033046)3.30123164
56telomere maintenance via recombination (GO:0000722)3.30037489
57mitotic G2/M transition checkpoint (GO:0044818)3.28339268
58positive regulation of chromosome segregation (GO:0051984)3.27508975
59metaphase plate congression (GO:0051310)3.27168293
60telomere maintenance via semi-conservative replication (GO:0032201)3.26387905
61histone exchange (GO:0043486)3.25694683
62negative regulation of DNA recombination (GO:0045910)3.24776603
63formation of translation preinitiation complex (GO:0001731)3.23232389
64regulation of centrosome cycle (GO:0046605)3.22998916
65regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20521920
66* regulation of chromosome segregation (GO:0051983)3.19965125
67regulation of histone H3-K9 methylation (GO:0051570)3.19745039
68nuclear envelope organization (GO:0006998)3.19358197
69RNA export from nucleus (GO:0006405)3.17678104
70regulation of centrosome duplication (GO:0010824)3.17462602
71IMP biosynthetic process (GO:0006188)3.16623101
72regulation of sister chromatid cohesion (GO:0007063)3.15891565
73DNA replication-independent nucleosome assembly (GO:0006336)3.15777799
74DNA replication-independent nucleosome organization (GO:0034724)3.15777799
75sister chromatid cohesion (GO:0007062)3.14949934
76negative regulation of mRNA metabolic process (GO:1903312)3.13986676
77histone H2A acetylation (GO:0043968)3.13176294
78mRNA transport (GO:0051028)3.13028033
79DNA ligation (GO:0006266)3.10751321
80* mitotic spindle assembly checkpoint (GO:0007094)3.10705194
81mRNA export from nucleus (GO:0006406)3.10565376
82somatic hypermutation of immunoglobulin genes (GO:0016446)3.10333775
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10333775
84* spindle assembly checkpoint (GO:0071173)3.08787763
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.07407642
86V(D)J recombination (GO:0033151)3.07341966
87DNA replication-dependent nucleosome assembly (GO:0006335)3.06336929
88DNA replication-dependent nucleosome organization (GO:0034723)3.06336929
89negative regulation of DNA repair (GO:0045738)3.05073330
90regulation of mitotic spindle checkpoint (GO:1903504)3.04948697
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04948697
92regulation of helicase activity (GO:0051095)3.03969077
93DNA conformation change (GO:0071103)3.01990602
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01254100
95dosage compensation (GO:0007549)3.00098182
96negative regulation of RNA splicing (GO:0033119)2.97330584
97meiotic chromosome segregation (GO:0045132)2.96031887
98negative regulation of translation, ncRNA-mediated (GO:0040033)2.95939879
99regulation of translation, ncRNA-mediated (GO:0045974)2.95939879
100negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.95939879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.68058044
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.54814757
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.35989713
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.49541452
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.23942074
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95898948
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.71272860
8ELK1_19687146_ChIP-ChIP_HELA_Human2.58567462
9PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35894786
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27071388
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.26434265
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.26377055
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.18222411
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.17514621
15EWS_26573619_Chip-Seq_HEK293_Human2.16178866
16* EST1_17652178_ChIP-ChIP_JURKAT_Human2.13951481
17PADI4_21655091_ChIP-ChIP_MCF-7_Human2.08315070
18AR_21909140_ChIP-Seq_LNCAP_Human2.08278832
19YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06222264
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05211668
21* VDR_23849224_ChIP-Seq_CD4+_Human2.01184971
22FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95391358
23FUS_26573619_Chip-Seq_HEK293_Human1.89835602
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84534363
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82547462
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.82046148
27FOXP3_21729870_ChIP-Seq_TREG_Human1.82003673
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74431439
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65377269
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64099129
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63786075
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63644898
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.63017394
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59655864
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55999920
36CIITA_25753668_ChIP-Seq_RAJI_Human1.52982688
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52220023
38DCP1A_22483619_ChIP-Seq_HELA_Human1.50713508
39GATA1_22025678_ChIP-Seq_K562_Human1.48245386
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46957284
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46913211
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41769023
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.40752933
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40507123
45IGF1R_20145208_ChIP-Seq_DFB_Human1.36704748
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34021384
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33734565
48TAF15_26573619_Chip-Seq_HEK293_Human1.31735557
49ZNF274_21170338_ChIP-Seq_K562_Hela1.31349059
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.30809731
51TTF2_22483619_ChIP-Seq_HELA_Human1.28479755
52KDM5A_27292631_Chip-Seq_BREAST_Human1.25672175
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25563994
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24783629
55E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21593855
56CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21456870
57MYC_18940864_ChIP-ChIP_HL60_Human1.16500759
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16004918
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09641857
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04600296
61GABP_19822575_ChIP-Seq_HepG2_Human1.04512324
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03206614
63VDR_22108803_ChIP-Seq_LS180_Human1.03188913
64POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98111707
65MYB_26560356_Chip-Seq_TH2_Human0.97260313
66ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96913336
67* XRN2_22483619_ChIP-Seq_HELA_Human0.96838520
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95694884
69E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95008298
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94948502
71IRF1_19129219_ChIP-ChIP_H3396_Human0.94649208
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94257395
73TFEB_21752829_ChIP-Seq_HELA_Human0.93908549
74NANOG_16153702_ChIP-ChIP_HESCs_Human0.93688110
75FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93670152
76* CHD1_26751641_Chip-Seq_LNCaP_Human0.90148992
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88634014
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88188076
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86268269
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86268269
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86268269
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85848404
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85770382
84SOX2_16153702_ChIP-ChIP_HESCs_Human0.83700902
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83458295
86* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83384766
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83080413
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82820898
89PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81753988
90P300_19829295_ChIP-Seq_ESCs_Human0.81228629
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81223431
92SALL4_22934838_ChIP-ChIP_CD34+_Human0.80648447
93EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.80039596
94FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79620848
95MYB_26560356_Chip-Seq_TH1_Human0.79108242
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77920596
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.76664205
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.75829352
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.75243899
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.74954600

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.62088163
2MP0010094_abnormal_chromosome_stability4.72385330
3MP0003111_abnormal_nucleus_morphology3.66415845
4MP0003693_abnormal_embryo_hatching3.63376085
5MP0004957_abnormal_blastocyst_morpholog3.37706108
6MP0003077_abnormal_cell_cycle3.23152492
7MP0008058_abnormal_DNA_repair3.22906217
8MP0002009_preneoplasia3.17783952
9MP0008007_abnormal_cellular_replicative3.16717232
10MP0002396_abnormal_hematopoietic_system2.84140730
11MP0010352_gastrointestinal_tract_polyps2.69072714
12MP0003890_abnormal_embryonic-extraembry2.46148277
13MP0008877_abnormal_DNA_methylation2.35267999
14MP0008932_abnormal_embryonic_tissue2.31065187
15MP0009697_abnormal_copulation2.05474344
16MP0010307_abnormal_tumor_latency1.98769390
17MP0000350_abnormal_cell_proliferation1.96816646
18MP0000569_abnormal_digit_pigmentation1.93572075
19MP0001730_embryonic_growth_arrest1.83156990
20MP0002166_altered_tumor_susceptibility1.78062151
21MP0001672_abnormal_embryogenesis/_devel1.72110081
22MP0005380_embryogenesis_phenotype1.72110081
23MP0003786_premature_aging1.71304822
24MP0003984_embryonic_growth_retardation1.64224651
25MP0001697_abnormal_embryo_size1.62326851
26MP0004808_abnormal_hematopoietic_stem1.60912903
27MP0002088_abnormal_embryonic_growth/wei1.60745463
28MP0000372_irregular_coat_pigmentation1.57842712
29MP0003567_abnormal_fetal_cardiomyocyte1.48107402
30MP0002006_tumorigenesis1.44071507
31MP0002084_abnormal_developmental_patter1.42518960
32MP0006292_abnormal_olfactory_placode1.38607974
33MP0004197_abnormal_fetal_growth/weight/1.38040234
34MP0003763_abnormal_thymus_physiology1.34648633
35MP0003718_maternal_effect1.33770635
36MP0002086_abnormal_extraembryonic_tissu1.31364079
37MP0001293_anophthalmia1.28244494
38MP0002080_prenatal_lethality1.26732981
39MP0003937_abnormal_limbs/digits/tail_de1.24446116
40MP0000313_abnormal_cell_death1.24412427
41MP0002085_abnormal_embryonic_tissue1.21760087
42MP0000703_abnormal_thymus_morphology1.19659904
43MP0005075_abnormal_melanosome_morpholog1.19535728
44MP0003221_abnormal_cardiomyocyte_apopto1.18426714
45MP0002019_abnormal_tumor_incidence1.18300573
46MP0009703_decreased_birth_body1.17834983
47MP0003943_abnormal_hepatobiliary_system1.16996021
48MP0009672_abnormal_birth_weight1.14880528
49MP0003941_abnormal_skin_development1.12074014
50MP0000427_abnormal_hair_cycle1.08453190
51MP0002938_white_spotting1.06820891
52MP0003787_abnormal_imprinting1.02965758
53MP0005076_abnormal_cell_differentiation1.02761748
54MP0008995_early_reproductive_senescence1.00664003
55MP0003121_genomic_imprinting0.96446947
56MP0005408_hypopigmentation0.93387472
57MP0000015_abnormal_ear_pigmentation0.92132311
58MP0002398_abnormal_bone_marrow0.85467330
59MP0001188_hyperpigmentation0.84914882
60MP0010678_abnormal_skin_adnexa0.84860527
61MP0002095_abnormal_skin_pigmentation0.84756598
62MP0000689_abnormal_spleen_morphology0.84721401
63MP0001286_abnormal_eye_development0.83366428
64MP0005621_abnormal_cell_physiology0.83326051
65MP0010234_abnormal_vibrissa_follicle0.82580713
66MP0000383_abnormal_hair_follicle0.81829885
67MP0001929_abnormal_gametogenesis0.79760787
68MP0004381_abnormal_hair_follicle0.79667638
69MP0005384_cellular_phenotype0.79582640
70MP0000647_abnormal_sebaceous_gland0.77536897
71MP0002722_abnormal_immune_system0.76932980
72MP0000516_abnormal_urinary_system0.74259056
73MP0005367_renal/urinary_system_phenotyp0.74259056
74MP0001177_atelectasis0.73575179
75MP0005174_abnormal_tail_pigmentation0.73066727
76MP0000428_abnormal_craniofacial_morphol0.72789352
77MP0004264_abnormal_extraembryonic_tissu0.72650936
78MP0001191_abnormal_skin_condition0.72403208
79MP0000371_diluted_coat_color0.71863960
80MP0002697_abnormal_eye_size0.71676971
81MP0000358_abnormal_cell_content/0.71515653
82MP0003656_abnormal_erythrocyte_physiolo0.71414465
83MP0002075_abnormal_coat/hair_pigmentati0.71304793
84MP0002210_abnormal_sex_determination0.69832411
85MP0005220_abnormal_exocrine_pancreas0.69531141
86MP0001145_abnormal_male_reproductive0.68348969
87MP0006035_abnormal_mitochondrial_morpho0.68117474
88MP0001119_abnormal_female_reproductive0.67565090
89MP0008961_abnormal_basal_metabolism0.65172012
90MP0000653_abnormal_sex_gland0.63493425
91MP0002092_abnormal_eye_morphology0.61247348
92MP0005171_absent_coat_pigmentation0.60935227
93MP0005395_other_phenotype0.59080667
94MP0006054_spinal_hemorrhage0.58753492
95MP0002102_abnormal_ear_morphology0.58716506
96MP0001186_pigmentation_phenotype0.58504162
97MP0002233_abnormal_nose_morphology0.58214072
98MP0000432_abnormal_head_morphology0.57681414
99MP0003136_yellow_coat_color0.57676421
100MP0003935_abnormal_craniofacial_develop0.57421969

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.74921006
2Chromsome breakage (HP:0040012)4.69462195
3Abnormality of chromosome stability (HP:0003220)3.93887444
4Volvulus (HP:0002580)3.63417227
5Birth length less than 3rd percentile (HP:0003561)3.60743479
6Nephroblastoma (Wilms tumor) (HP:0002667)3.11154949
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.08676600
8Meckel diverticulum (HP:0002245)3.06871500
9Acute myeloid leukemia (HP:0004808)3.06735625
10Abnormality of the ileum (HP:0001549)2.96076789
11Embryonal renal neoplasm (HP:0011794)2.95444098
12Abnormality of the preputium (HP:0100587)2.91214759
13Myelodysplasia (HP:0002863)2.84044723
14Clubbing of toes (HP:0100760)2.80667224
15Panhypogammaglobulinemia (HP:0003139)2.78102769
16Small intestinal stenosis (HP:0012848)2.72270789
17Duodenal stenosis (HP:0100867)2.72270789
18Severe combined immunodeficiency (HP:0004430)2.67006156
19Combined immunodeficiency (HP:0005387)2.61404101
20Sloping forehead (HP:0000340)2.60175679
21Colon cancer (HP:0003003)2.58935995
22Rhabdomyosarcoma (HP:0002859)2.57509514
23B lymphocytopenia (HP:0010976)2.56669451
24Ectopic kidney (HP:0000086)2.47541705
25Abnormal lung lobation (HP:0002101)2.45536039
26Absent radius (HP:0003974)2.42496249
27Thyroiditis (HP:0100646)2.41038984
28Abnormality of the duodenum (HP:0002246)2.39055591
29Abnormality of B cell number (HP:0010975)2.39009837
30Acute lymphatic leukemia (HP:0006721)2.38918016
31Hypoplasia of the thymus (HP:0000778)2.35816861
32Homocystinuria (HP:0002156)2.33973243
33Abnormality of homocysteine metabolism (HP:0010919)2.33973243
34Prominent nose (HP:0000448)2.32530386
35Cafe-au-lait spot (HP:0000957)2.30981680
36Medulloblastoma (HP:0002885)2.29630802
37Sandal gap (HP:0001852)2.28266920
38Deep philtrum (HP:0002002)2.22497826
39Abnormality of the labia minora (HP:0012880)2.20832960
40Aplasia involving forearm bones (HP:0009822)2.19994036
41Absent forearm bone (HP:0003953)2.19994036
42T lymphocytopenia (HP:0005403)2.15465513
43Carpal bone hypoplasia (HP:0001498)2.14859443
44Curly hair (HP:0002212)2.14519288
45Glioma (HP:0009733)2.14474845
46Abnormality of the fingertips (HP:0001211)2.14358775
47Pancreatic islet-cell hyperplasia (HP:0004510)2.14278210
48Ependymoma (HP:0002888)2.13175258
49Overlapping toe (HP:0001845)2.08455027
50Long clavicles (HP:0000890)2.05419497
51Abnormality of chromosome segregation (HP:0002916)2.00266985
52Papillary thyroid carcinoma (HP:0002895)2.00093002
53Cortical dysplasia (HP:0002539)1.99942059
54Astrocytoma (HP:0009592)1.99404192
55Abnormality of the astrocytes (HP:0100707)1.99404192
56Abnormal hair whorl (HP:0010721)1.97763920
57Cystic hygroma (HP:0000476)1.97698948
58Duplicated collecting system (HP:0000081)1.95446095
59Neoplasm of striated muscle (HP:0009728)1.95081736
60Aqueductal stenosis (HP:0002410)1.94561542
61Neoplasm of the small intestine (HP:0100833)1.93350225
62Neoplasm of the colon (HP:0100273)1.92216148
63Submucous cleft hard palate (HP:0000176)1.89200122
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87946683
65Abnormality of alanine metabolism (HP:0010916)1.87946683
66Hyperalaninemia (HP:0003348)1.87946683
67Abnormality of DNA repair (HP:0003254)1.87047526
68Biliary tract neoplasm (HP:0100574)1.85688405
69Abnormality of the carotid arteries (HP:0005344)1.84138280
70Increased nuchal translucency (HP:0010880)1.82773989
71Recurrent viral infections (HP:0004429)1.82404837
72Hypoproteinemia (HP:0003075)1.80735341
73Embryonal neoplasm (HP:0002898)1.80243848
74Neoplasm of the adrenal cortex (HP:0100641)1.79826585
75Ovarian neoplasm (HP:0100615)1.79520833
76Abnormality of T cell number (HP:0011839)1.78829090
77Abnormality of methionine metabolism (HP:0010901)1.78731809
78Intestinal atresia (HP:0011100)1.77067302
79Basal cell carcinoma (HP:0002671)1.74457870
80Abnormality of the renal collecting system (HP:0004742)1.73375608
81Malignant gastrointestinal tract tumors (HP:0006749)1.71371741
82Gastrointestinal carcinoma (HP:0002672)1.71371741
83Arteriovenous malformation (HP:0100026)1.71264919
84Abnormality of the pons (HP:0007361)1.70987039
85Cupped ear (HP:0000378)1.70738434
86Transitional cell carcinoma of the bladder (HP:0006740)1.70570277
87Hypopigmentation of the fundus (HP:0007894)1.67555318
88Patellar aplasia (HP:0006443)1.67208338
89Stenosis of the external auditory canal (HP:0000402)1.66115347
90Anal stenosis (HP:0002025)1.66019666
91Cutis marmorata (HP:0000965)1.65745302
92Cellular immunodeficiency (HP:0005374)1.65511438
93Triphalangeal thumb (HP:0001199)1.65393990
94Lymphoma (HP:0002665)1.64966986
95Capillary hemangiomas (HP:0005306)1.64306196
96Breast carcinoma (HP:0003002)1.64180268
97Protruding tongue (HP:0010808)1.63815348
98Clitoromegaly (HP:0000057)1.63054858
99IgM deficiency (HP:0002850)1.62790805
100Hypoplasia of the pons (HP:0012110)1.61414505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK23.62888277
2MKNK13.20831756
3BRD43.16521174
4EIF2AK33.14123948
5BUB13.10532675
6SRPK13.06785597
7CDC73.04491113
8FRK2.70015883
9BRSK22.45007148
10WEE12.42204329
11CDK122.37404653
12TTK2.31499218
13ACVR1B2.28999761
14TRIM282.22869641
15AKT32.15987738
16NUAK12.13928444
17PLK42.05084812
18BMPR1B1.90278726
19TSSK61.88082444
20PLK31.83983185
21NLK1.59299548
22LATS11.51662090
23ATR1.50190253
24MST41.46317980
25NEK11.45009082
26EIF2AK11.42941489
27TNIK1.40651474
28PBK1.38840714
29STK31.38588717
30PDK21.34254638
31TAF11.29769538
32CDK61.29676289
33ERBB31.27641009
34CHEK21.25621598
35ZAK1.22042507
36PLK11.18454865
37CHEK11.09029871
38ATM1.08486833
39EIF2AK21.05226290
40MELK1.04428176
41RPS6KA41.03056280
42YES11.02474810
43MAP3K101.01184914
44TEC0.97886549
45TGFBR10.92726539
46BCR0.91851549
47CAMK1D0.89292158
48IRAK10.87244020
49WNK30.84897509
50CAMK1G0.83251404
51NEK20.81817370
52DYRK30.79478040
53STK38L0.78916742
54AURKB0.77785679
55SCYL20.75025925
56VRK10.74492199
57CDK40.70065077
58SIK30.69687897
59CDK70.68879256
60CLK10.68778541
61FGFR30.68627115
62PLK20.67281982
63MAP3K40.65823385
64BRSK10.65717445
65FGFR10.65209371
66ALK0.65197829
67CDK190.63412741
68SGK20.62040045
69CDK10.61574100
70PASK0.60472955
71FGFR20.59404924
72CDK30.57907962
73CDK20.57048285
74STK40.55304360
75MAP4K20.54037789
76RPS6KB20.52669737
77EEF2K0.51467956
78CSNK1G10.48225897
79NEK90.45164045
80CSNK1A1L0.44587450
81BMPR20.44107309
82CCNB10.40741319
83FLT30.40512847
84MAP3K140.38686936
85PRKDC0.36565499
86SGK30.36479822
87KSR10.35765385
88CDK90.35524647
89NEK60.33359502
90PIM10.32594263
91MARK30.32440743
92STK100.31141938
93TRPM70.30900259
94DYRK1A0.30080314
95RAF10.29584716
96PNCK0.29140417
97MAP3K80.26752149
98WNK10.25975582
99FER0.25815487
100STK240.24499269

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.82986287
2DNA replication_Homo sapiens_hsa030303.74464707
3Mismatch repair_Homo sapiens_hsa034303.53811516
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.48059354
5Homologous recombination_Homo sapiens_hsa034403.31597571
6RNA transport_Homo sapiens_hsa030133.13289992
7Fanconi anemia pathway_Homo sapiens_hsa034603.07866637
8Cell cycle_Homo sapiens_hsa041102.98185781
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.95005046
10Spliceosome_Homo sapiens_hsa030402.86430062
11mRNA surveillance pathway_Homo sapiens_hsa030152.43014199
12Basal transcription factors_Homo sapiens_hsa030222.33352607
13RNA degradation_Homo sapiens_hsa030182.28825367
14Nucleotide excision repair_Homo sapiens_hsa034202.27853884
15One carbon pool by folate_Homo sapiens_hsa006702.20558629
16Base excision repair_Homo sapiens_hsa034102.14586735
17Selenocompound metabolism_Homo sapiens_hsa004501.91010917
18RNA polymerase_Homo sapiens_hsa030201.72075696
19p53 signaling pathway_Homo sapiens_hsa041151.66447202
20Proteasome_Homo sapiens_hsa030501.61774198
21Lysine degradation_Homo sapiens_hsa003101.52775602
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49870595
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46456185
24Protein export_Homo sapiens_hsa030601.32592801
25Propanoate metabolism_Homo sapiens_hsa006401.31815362
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.30569888
27Pyrimidine metabolism_Homo sapiens_hsa002401.19717798
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19490234
29Colorectal cancer_Homo sapiens_hsa052101.12404953
30Primary immunodeficiency_Homo sapiens_hsa053401.11721489
31MicroRNAs in cancer_Homo sapiens_hsa052061.10699045
32Oocyte meiosis_Homo sapiens_hsa041141.07560475
33Viral carcinogenesis_Homo sapiens_hsa052031.07072241
34Thyroid cancer_Homo sapiens_hsa052161.03687763
35Prostate cancer_Homo sapiens_hsa052151.00598326
36Epstein-Barr virus infection_Homo sapiens_hsa051690.97323456
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96115992
38TGF-beta signaling pathway_Homo sapiens_hsa043500.91571224
39Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88526970
40Herpes simplex infection_Homo sapiens_hsa051680.86502435
41Purine metabolism_Homo sapiens_hsa002300.83701273
42Adherens junction_Homo sapiens_hsa045200.81303585
43Chronic myeloid leukemia_Homo sapiens_hsa052200.79454657
44Hepatitis B_Homo sapiens_hsa051610.75669039
45FoxO signaling pathway_Homo sapiens_hsa040680.74775126
46Steroid biosynthesis_Homo sapiens_hsa001000.68975329
47Pancreatic cancer_Homo sapiens_hsa052120.67900727
48Measles_Homo sapiens_hsa051620.67746002
49Systemic lupus erythematosus_Homo sapiens_hsa053220.67604331
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67516017
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61623939
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61161416
53Non-small cell lung cancer_Homo sapiens_hsa052230.60488358
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60327022
55HTLV-I infection_Homo sapiens_hsa051660.58904588
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55483630
57Small cell lung cancer_Homo sapiens_hsa052220.53479380
58Inositol phosphate metabolism_Homo sapiens_hsa005620.51919141
59Vitamin B6 metabolism_Homo sapiens_hsa007500.51739275
60Circadian rhythm_Homo sapiens_hsa047100.51584770
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51438556
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48834937
63Vitamin digestion and absorption_Homo sapiens_hsa049770.45181678
64Acute myeloid leukemia_Homo sapiens_hsa052210.44738547
65N-Glycan biosynthesis_Homo sapiens_hsa005100.43855741
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.43783255
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40742663
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39952551
69Pyruvate metabolism_Homo sapiens_hsa006200.38562623
70Influenza A_Homo sapiens_hsa051640.37672300
71Alcoholism_Homo sapiens_hsa050340.36301337
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36125237
73Legionellosis_Homo sapiens_hsa051340.36012724
74Biosynthesis of amino acids_Homo sapiens_hsa012300.34689308
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34067825
76Hippo signaling pathway_Homo sapiens_hsa043900.33257949
77Wnt signaling pathway_Homo sapiens_hsa043100.32653335
78Endometrial cancer_Homo sapiens_hsa052130.32389282
79Antigen processing and presentation_Homo sapiens_hsa046120.32317504
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.30868575
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29776026
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28934101
83T cell receptor signaling pathway_Homo sapiens_hsa046600.28340547
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27777729
85mTOR signaling pathway_Homo sapiens_hsa041500.27192732
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27166267
87B cell receptor signaling pathway_Homo sapiens_hsa046620.26927548
88Melanoma_Homo sapiens_hsa052180.25361638
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23324957
90Apoptosis_Homo sapiens_hsa042100.22222198
91Carbon metabolism_Homo sapiens_hsa012000.20915114
92Pathways in cancer_Homo sapiens_hsa052000.20234317
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19768335
94Nitrogen metabolism_Homo sapiens_hsa009100.19360056
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17269917
96Sulfur metabolism_Homo sapiens_hsa009200.17139973
97Renal cell carcinoma_Homo sapiens_hsa052110.14673756
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14486912
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.13694143
100Ether lipid metabolism_Homo sapiens_hsa005650.13233586

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