ZNF208

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.72707114
2response to pheromone (GO:0019236)4.14865301
3negative regulation of telomere maintenance (GO:0032205)4.06527904
4protein-cofactor linkage (GO:0018065)3.79716747
5platelet dense granule organization (GO:0060155)3.74082940
6mitochondrial respiratory chain complex I assembly (GO:0032981)3.65342916
7NADH dehydrogenase complex assembly (GO:0010257)3.65342916
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65342916
9protein complex biogenesis (GO:0070271)3.60995464
10otic vesicle formation (GO:0030916)3.52698685
11DNA deamination (GO:0045006)3.41039526
12mitochondrial respiratory chain complex assembly (GO:0033108)3.38525769
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.34931066
14detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.31079392
15kidney morphogenesis (GO:0060993)3.29154884
16water-soluble vitamin biosynthetic process (GO:0042364)3.19520588
17negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.17214853
18negative regulation of translation, ncRNA-mediated (GO:0040033)3.17214853
19regulation of translation, ncRNA-mediated (GO:0045974)3.17214853
20regulation of gene silencing by miRNA (GO:0060964)3.13617017
21regulation of gene silencing by RNA (GO:0060966)3.13617017
22regulation of posttranscriptional gene silencing (GO:0060147)3.13617017
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12732379
24kynurenine metabolic process (GO:0070189)3.11993584
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10090304
26sulfation (GO:0051923)3.09556308
27regulation of nuclear cell cycle DNA replication (GO:0033262)3.05211391
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03525974
29ATP synthesis coupled proton transport (GO:0015986)3.03525974
30L-fucose catabolic process (GO:0042355)2.98955735
31fucose catabolic process (GO:0019317)2.98955735
32L-fucose metabolic process (GO:0042354)2.98955735
33replication fork processing (GO:0031297)2.97638817
34epithelial cilium movement (GO:0003351)2.96079955
35cullin deneddylation (GO:0010388)2.94948839
36maturation of 5.8S rRNA (GO:0000460)2.94438201
37tryptophan catabolic process (GO:0006569)2.94093712
38indole-containing compound catabolic process (GO:0042436)2.94093712
39indolalkylamine catabolic process (GO:0046218)2.94093712
40cellular ketone body metabolic process (GO:0046950)2.93482754
41regulation of telomere maintenance (GO:0032204)2.91449468
42indolalkylamine metabolic process (GO:0006586)2.89533891
43establishment of protein localization to mitochondrial membrane (GO:0090151)2.86069814
44respiratory chain complex IV assembly (GO:0008535)2.85472986
45somite development (GO:0061053)2.85011023
46regulation of telomere maintenance via telomerase (GO:0032210)2.83338540
47nonmotile primary cilium assembly (GO:0035058)2.82780543
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80122527
49regulation of helicase activity (GO:0051095)2.76019735
50negative regulation of DNA-dependent DNA replication (GO:2000104)2.75293363
51preassembly of GPI anchor in ER membrane (GO:0016254)2.72958521
52protein deneddylation (GO:0000338)2.72695838
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72327838
54photoreceptor cell maintenance (GO:0045494)2.70366797
55glycerophospholipid catabolic process (GO:0046475)2.70360133
56ketone body metabolic process (GO:1902224)2.70072522
57regulation of mesoderm development (GO:2000380)2.69301325
58synapsis (GO:0007129)2.65928243
59retinal cone cell development (GO:0046549)2.65222887
60DNA double-strand break processing (GO:0000729)2.64851400
61regulation of action potential (GO:0098900)2.63998433
62piRNA metabolic process (GO:0034587)2.63774026
63male meiosis I (GO:0007141)2.62717787
64protein neddylation (GO:0045116)2.60102503
65electron transport chain (GO:0022900)2.60063329
66DNA damage response, detection of DNA damage (GO:0042769)2.59422001
67centriole replication (GO:0007099)2.58815918
68detection of light stimulus involved in sensory perception (GO:0050962)2.58808005
69detection of light stimulus involved in visual perception (GO:0050908)2.58808005
70cilium morphogenesis (GO:0060271)2.58327869
71regulation of mitotic spindle checkpoint (GO:1903504)2.57108807
72regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.57108807
73protein localization to cilium (GO:0061512)2.56678038
74dopamine transport (GO:0015872)2.56591619
75reciprocal meiotic recombination (GO:0007131)2.56512328
76reciprocal DNA recombination (GO:0035825)2.56512328
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55807416
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55807416
79reflex (GO:0060004)2.54765809
80respiratory electron transport chain (GO:0022904)2.54720857
81adaptation of signaling pathway (GO:0023058)2.53971524
82single strand break repair (GO:0000012)2.53791495
83recombinational repair (GO:0000725)2.52968529
84cytochrome complex assembly (GO:0017004)2.52700109
85tryptophan metabolic process (GO:0006568)2.52281484
86spinal cord motor neuron differentiation (GO:0021522)2.52013268
87double-strand break repair via homologous recombination (GO:0000724)2.49293244
88resolution of meiotic recombination intermediates (GO:0000712)2.49106327
89peptidyl-histidine modification (GO:0018202)2.46351784
90regulation of meiosis I (GO:0060631)2.45624040
91neuronal action potential (GO:0019228)2.45334641
92axoneme assembly (GO:0035082)2.43085909
93synaptic transmission, cholinergic (GO:0007271)2.42957913
94rRNA catabolic process (GO:0016075)2.42824860
95regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.41889330
96regulation of glucokinase activity (GO:0033131)2.41709708
97regulation of hexokinase activity (GO:1903299)2.41709708
98pyrimidine nucleobase catabolic process (GO:0006208)2.41463436
99photoreceptor cell development (GO:0042461)2.41419458
100telomere maintenance via telomerase (GO:0007004)2.40948962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.73481102
2VDR_22108803_ChIP-Seq_LS180_Human3.33939486
3GBX2_23144817_ChIP-Seq_PC3_Human2.95576330
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71813449
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50200108
6FUS_26573619_Chip-Seq_HEK293_Human2.39833306
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39004794
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.38711760
9IGF1R_20145208_ChIP-Seq_DFB_Human2.33498054
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32663674
11TAF15_26573619_Chip-Seq_HEK293_Human2.32402954
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28155498
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28154474
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.25067453
15EWS_26573619_Chip-Seq_HEK293_Human2.22793652
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21850173
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18623235
18* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13861527
19P300_19829295_ChIP-Seq_ESCs_Human2.13071083
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01442047
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00073371
22EZH2_22144423_ChIP-Seq_EOC_Human1.97233298
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.93949409
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87097941
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86308247
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82256364
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.78465111
28ER_23166858_ChIP-Seq_MCF-7_Human1.73849439
29BCAT_22108803_ChIP-Seq_LS180_Human1.71008338
30MYC_18940864_ChIP-ChIP_HL60_Human1.60920382
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55749067
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54500191
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54135629
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50606337
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.50059002
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49386338
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45662932
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.45122764
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44737619
40ELK1_19687146_ChIP-ChIP_HELA_Human1.44644105
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44485157
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.42600796
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41890445
44CBP_20019798_ChIP-Seq_JUKART_Human1.41890445
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41254782
46SMAD4_21799915_ChIP-Seq_A2780_Human1.41115009
47* STAT3_23295773_ChIP-Seq_U87_Human1.41017504
48TP53_22573176_ChIP-Seq_HFKS_Human1.40748306
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39920376
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39830326
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39738307
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39153025
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39153025
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38977384
55* TCF4_23295773_ChIP-Seq_U87_Human1.38173645
56IRF1_19129219_ChIP-ChIP_H3396_Human1.34684037
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34307673
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.33368993
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33117827
60AR_25329375_ChIP-Seq_VCAP_Human1.32761355
61TCF4_22108803_ChIP-Seq_LS180_Human1.31285267
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31149908
63NANOG_19829295_ChIP-Seq_ESCs_Human1.30509663
64SOX2_19829295_ChIP-Seq_ESCs_Human1.30509663
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27652373
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.27482459
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27014537
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.27014537
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24266502
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21906014
71RNF2_27304074_Chip-Seq_NSC_Mouse1.20753802
72RUNX2_22187159_ChIP-Seq_PCA_Human1.19884415
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17653816
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.17075939
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14801491
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.13734813
77REST_21632747_ChIP-Seq_MESCs_Mouse1.12877119
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.08545969
79NCOR_22424771_ChIP-Seq_293T_Human1.07658123
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07002548
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06530291
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06306949
83AR_21572438_ChIP-Seq_LNCaP_Human1.05970877
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04656585
85VDR_23849224_ChIP-Seq_CD4+_Human1.04358733
86AR_20517297_ChIP-Seq_VCAP_Human1.03248329
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.02313613
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02178195
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01466982
90P53_22387025_ChIP-Seq_ESCs_Mouse0.99198727
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.99082900
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98967663
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97930369
94STAT3_18555785_Chip-Seq_ESCs_Mouse0.97550737
95FLI1_21867929_ChIP-Seq_TH2_Mouse0.97381889
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.96617014
97E2F1_18555785_Chip-Seq_ESCs_Mouse0.95737820
98ETS1_20019798_ChIP-Seq_JURKAT_Human0.95175613
99HOXB7_26014856_ChIP-Seq_BT474_Human0.94401384
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.93450504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.21456252
2MP0006292_abnormal_olfactory_placode2.67938580
3MP0002837_dystrophic_cardiac_calcinosis2.53693583
4MP0003195_calcinosis2.52515124
5MP0003136_yellow_coat_color2.47611864
6MP0004133_heterotaxia2.29108621
7MP0005551_abnormal_eye_electrophysiolog2.23906039
8MP0002736_abnormal_nociception_after2.19917711
9MP0006072_abnormal_retinal_apoptosis2.19852036
10MP0001968_abnormal_touch/_nociception2.11519181
11MP0009046_muscle_twitch2.06760917
12MP0003880_abnormal_central_pattern2.04742823
13MP0002102_abnormal_ear_morphology2.02478372
14MP0003787_abnormal_imprinting1.98101232
15MP0001986_abnormal_taste_sensitivity1.98087642
16MP0002876_abnormal_thyroid_physiology1.92597443
17MP0002938_white_spotting1.85484502
18MP0002254_reproductive_system_inflammat1.84366227
19MP0003646_muscle_fatigue1.83120611
20MP0003890_abnormal_embryonic-extraembry1.82443099
21MP0005646_abnormal_pituitary_gland1.77755613
22MP0000631_abnormal_neuroendocrine_gland1.74184143
23MP0000569_abnormal_digit_pigmentation1.73102001
24MP0006276_abnormal_autonomic_nervous1.65461021
25MP0001984_abnormal_olfaction1.65092024
26MP0003718_maternal_effect1.64695434
27MP0009745_abnormal_behavioral_response1.64164759
28MP0005253_abnormal_eye_physiology1.62114204
29MP0001485_abnormal_pinna_reflex1.60690336
30MP0008872_abnormal_physiological_respon1.56953128
31MP0002272_abnormal_nervous_system1.55706969
32MP0005645_abnormal_hypothalamus_physiol1.54106737
33MP0004147_increased_porphyrin_level1.54059416
34MP0008995_early_reproductive_senescence1.52387550
35MP0004885_abnormal_endolymph1.49266990
36MP0000427_abnormal_hair_cycle1.49215033
37MP0003011_delayed_dark_adaptation1.44652279
38MP0008058_abnormal_DNA_repair1.43695219
39MP0008875_abnormal_xenobiotic_pharmacok1.41766999
40MP0001486_abnormal_startle_reflex1.40638293
41MP0003283_abnormal_digestive_organ1.40306310
42MP0002638_abnormal_pupillary_reflex1.39859724
43MP0004142_abnormal_muscle_tone1.38611991
44MP0002163_abnormal_gland_morphology1.36923587
45MP0002735_abnormal_chemical_nociception1.36697140
46MP0002277_abnormal_respiratory_mucosa1.28545504
47MP0000372_irregular_coat_pigmentation1.28442023
48MP0001293_anophthalmia1.23455649
49MP0004742_abnormal_vestibular_system1.21581339
50MP0002557_abnormal_social/conspecific_i1.19654295
51MP0002572_abnormal_emotion/affect_behav1.15389330
52MP0005379_endocrine/exocrine_gland_phen1.12181876
53MP0003567_abnormal_fetal_cardiomyocyte1.11431881
54MP0005174_abnormal_tail_pigmentation1.10625130
55MP0002064_seizures1.10350869
56MP0002160_abnormal_reproductive_system1.10268429
57MP0000383_abnormal_hair_follicle1.10171050
58MP0005389_reproductive_system_phenotype1.07932089
59MP0001501_abnormal_sleep_pattern1.07681804
60MP0003121_genomic_imprinting1.06874140
61MP0002734_abnormal_mechanical_nocicepti1.06287916
62MP0004215_abnormal_myocardial_fiber1.05409987
63MP0003937_abnormal_limbs/digits/tail_de1.04508974
64MP0003119_abnormal_digestive_system1.03445120
65MP0001529_abnormal_vocalization1.02954868
66MP0002067_abnormal_sensory_capabilities1.02924450
67MP0005195_abnormal_posterior_eye1.01498960
68MP0000647_abnormal_sebaceous_gland1.01275749
69MP0005410_abnormal_fertilization1.01107394
70MP0002751_abnormal_autonomic_nervous1.01053885
71MP0003635_abnormal_synaptic_transmissio0.99536469
72MP0005075_abnormal_melanosome_morpholog0.97622198
73MP0002210_abnormal_sex_determination0.95569419
74MP0001970_abnormal_pain_threshold0.95450622
75MP0010386_abnormal_urinary_bladder0.94125760
76MP0003698_abnormal_male_reproductive0.93835673
77MP0001929_abnormal_gametogenesis0.93602768
78MP0002733_abnormal_thermal_nociception0.92467064
79MP0005084_abnormal_gallbladder_morpholo0.91981081
80MP0003122_maternal_imprinting0.90622246
81MP0005377_hearing/vestibular/ear_phenot0.89624793
82MP0003878_abnormal_ear_physiology0.89624793
83MP0003938_abnormal_ear_development0.89438343
84MP0001919_abnormal_reproductive_system0.89327851
85MP0002063_abnormal_learning/memory/cond0.88402695
86MP0001324_abnormal_eye_pigmentation0.85849179
87MP0004043_abnormal_pH_regulation0.84800872
88MP0004145_abnormal_muscle_electrophysio0.84229366
89MP0004924_abnormal_behavior0.84209425
90MP0005386_behavior/neurological_phenoty0.84209425
91MP0002653_abnormal_ependyma_morphology0.84137432
92MP0000653_abnormal_sex_gland0.84069958
93MP0002752_abnormal_somatic_nervous0.83876492
94MP0008775_abnormal_heart_ventricle0.83739107
95MP0000778_abnormal_nervous_system0.82965707
96MP0000230_abnormal_systemic_arterial0.82323953
97MP0003137_abnormal_impulse_conducting0.81766944
98MP0001905_abnormal_dopamine_level0.80075225
99MP0001188_hyperpigmentation0.79956529
100MP0005332_abnormal_amino_acid0.79561197

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.07981114
2Pancreatic fibrosis (HP:0100732)3.85672063
3Molar tooth sign on MRI (HP:0002419)3.68755143
4Abnormality of midbrain morphology (HP:0002418)3.68755143
5True hermaphroditism (HP:0010459)3.66553261
6Congenital stationary night blindness (HP:0007642)3.58681652
7Nephronophthisis (HP:0000090)3.19442591
8Pendular nystagmus (HP:0012043)2.89854024
9Type II lissencephaly (HP:0007260)2.88293526
10Medial flaring of the eyebrow (HP:0010747)2.83092474
11Chronic hepatic failure (HP:0100626)2.80465992
12Abnormality of the renal medulla (HP:0100957)2.77922396
13Abnormality of the renal cortex (HP:0011035)2.72968667
14Hyperventilation (HP:0002883)2.72160194
15Abnormality of the labia minora (HP:0012880)2.66148388
16Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.63153923
17Septo-optic dysplasia (HP:0100842)2.62535081
18Abolished electroretinogram (ERG) (HP:0000550)2.61321048
19Optic nerve hypoplasia (HP:0000609)2.60168507
20Acute necrotizing encephalopathy (HP:0006965)2.54333186
21Cystic liver disease (HP:0006706)2.52330807
22Colon cancer (HP:0003003)2.52061068
23Methylmalonic acidemia (HP:0002912)2.48548605
24Mitochondrial inheritance (HP:0001427)2.36542949
25Increased CSF lactate (HP:0002490)2.36090012
26Sclerocornea (HP:0000647)2.33760288
27Intestinal atresia (HP:0011100)2.33135375
28Gaze-evoked nystagmus (HP:0000640)2.26788923
29Progressive macrocephaly (HP:0004481)2.25439338
30Acute encephalopathy (HP:0006846)2.24103144
31Gait imbalance (HP:0002141)2.23006933
32Bilateral microphthalmos (HP:0007633)2.21646532
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20447286
34Abnormality of alanine metabolism (HP:0010916)2.20447286
35Hyperalaninemia (HP:0003348)2.20447286
36Methylmalonic aciduria (HP:0012120)2.19904973
37Genital tract atresia (HP:0001827)2.18937872
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.18720771
39Vaginal atresia (HP:0000148)2.18540332
40Anencephaly (HP:0002323)2.18423077
41Congenital primary aphakia (HP:0007707)2.18166134
42Abnormal biliary tract physiology (HP:0012439)2.12684834
43Bile duct proliferation (HP:0001408)2.12684834
44Nephrogenic diabetes insipidus (HP:0009806)2.12311076
45Gastrointestinal atresia (HP:0002589)2.12262139
46Tubular atrophy (HP:0000092)2.11150732
47Renal cortical cysts (HP:0000803)2.10766068
48Abnormal rod and cone electroretinograms (HP:0008323)2.10756253
49Inability to walk (HP:0002540)2.10594961
50Abnormal mitochondria in muscle tissue (HP:0008316)2.10061304
51Esophageal atresia (HP:0002032)2.08976388
52Attenuation of retinal blood vessels (HP:0007843)2.08788833
53Progressive cerebellar ataxia (HP:0002073)2.08002151
54Cerebellar dysplasia (HP:0007033)2.04953503
55Hyperglycinuria (HP:0003108)2.03867858
56Broad-based gait (HP:0002136)2.03156528
57Abnormality of the ileum (HP:0001549)2.01050777
58Abnormality of the pons (HP:0007361)1.99611883
59Progressive inability to walk (HP:0002505)1.99389367
60Meckel diverticulum (HP:0002245)1.97556520
61Male pseudohermaphroditism (HP:0000037)1.97489600
62Hypoplasia of the pons (HP:0012110)1.96938860
63Hepatocellular necrosis (HP:0001404)1.96327882
64Increased corneal curvature (HP:0100692)1.95225165
65Keratoconus (HP:0000563)1.95225165
66Large for gestational age (HP:0001520)1.94416417
67Lissencephaly (HP:0001339)1.92334291
68Abnormality of macular pigmentation (HP:0008002)1.91803753
69Polydipsia (HP:0001959)1.90776118
70Abnormal drinking behavior (HP:0030082)1.90776118
71Furrowed tongue (HP:0000221)1.89756465
72Aplasia/Hypoplasia of the tongue (HP:0010295)1.88479388
73Dialeptic seizures (HP:0011146)1.88377218
74Congenital, generalized hypertrichosis (HP:0004540)1.86582236
75Aplasia/Hypoplasia of the tibia (HP:0005772)1.86270616
76Oligodactyly (hands) (HP:0001180)1.85387893
77Hepatic necrosis (HP:0002605)1.84735809
78Stomach cancer (HP:0012126)1.82253902
79Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.81777608
80Congenital hepatic fibrosis (HP:0002612)1.79992971
81Focal seizures (HP:0007359)1.79619472
82Hypomagnesemia (HP:0002917)1.77826255
83Aplasia/Hypoplasia of the fovea (HP:0008060)1.77262988
84Hypoplasia of the fovea (HP:0007750)1.77262988
85Abnormality of the renal collecting system (HP:0004742)1.71899998
86Optic disc pallor (HP:0000543)1.71790046
87Genetic anticipation (HP:0003743)1.71211541
88Focal motor seizures (HP:0011153)1.70538377
89Dandy-Walker malformation (HP:0001305)1.70372125
90Hypothermia (HP:0002045)1.70276430
91Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69530106
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.68803358
93Hyperglycinemia (HP:0002154)1.66743138
94Dynein arm defect of respiratory motile cilia (HP:0012255)1.66680931
95Absent/shortened dynein arms (HP:0200106)1.66680931
96Stenosis of the external auditory canal (HP:0000402)1.66462496
97Febrile seizures (HP:0002373)1.66396643
98Anophthalmia (HP:0000528)1.66313462
99Lipid accumulation in hepatocytes (HP:0006561)1.66057677
100Absent septum pellucidum (HP:0001331)1.65573528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.74596475
2WNK33.37128166
3NUAK12.81114770
4ZAK2.62313377
5MAP4K22.56285588
6ADRBK22.53322976
7CASK2.47083632
8BMPR1B2.44221002
9TLK12.44075887
10GRK12.37036572
11TNIK2.28213539
12PINK12.19855314
13ACVR1B2.10713990
14VRK21.83267651
15OXSR11.78379387
16WNK41.73700877
17MAP3K41.70543334
18CDK191.57172834
19INSRR1.53593838
20FGFR21.48295218
21DYRK21.42864398
22MAPK131.41342952
23MAP2K61.36128618
24PNCK1.33077702
25PAK31.29227555
26CDC71.28364203
27TXK1.26770012
28MST41.19611466
29TRIM281.17009790
30VRK11.14795712
31MKNK21.14744768
32BRSK21.14348055
33PLK31.13949267
34TAF11.11222741
35PLK41.08947855
36NME11.08628422
37TAOK31.02502034
38PRKCE1.02052746
39PRKCG1.00382542
40PASK0.97401787
41STK38L0.96770817
42PLK20.94615962
43STK390.89912323
44MAP2K70.89582779
45BCR0.88997353
46TIE10.88696818
47STK160.88631929
48CSNK1G10.87788249
49ADRBK10.87313027
50TGFBR10.86687732
51DAPK20.85057368
52TSSK60.80588503
53WEE10.79791118
54DYRK30.79374835
55NLK0.79134003
56CSNK1G20.78365808
57MARK10.75563853
58NEK20.69698833
59NTRK30.69593765
60MKNK10.67451240
61PHKG10.65837452
62PHKG20.65837452
63PLK10.65672046
64MUSK0.62171612
65TEC0.62025837
66TAOK20.61172657
67PIK3CA0.59819560
68OBSCN0.59805666
69CSNK1G30.59577225
70BUB10.57062396
71TTK0.56304260
72PKN10.54089698
73CHEK20.53934042
74MAPKAPK50.52275138
75EPHA40.50612254
76STK30.50556678
77BCKDK0.49865480
78NTRK20.49750493
79AKT30.48250438
80CAMK2A0.47974261
81CSNK1A10.47003482
82STK110.46555573
83ATR0.46109869
84ATM0.45714907
85PRKCQ0.44602185
86PRKACA0.44075401
87PBK0.41373827
88PRKACB0.39528671
89SIK20.39254298
90PDK20.38182242
91RPS6KA50.37618536
92CSNK1A1L0.37455092
93PRKG10.37217243
94FGFR10.35000022
95EIF2AK30.34909626
96ITK0.34866907
97DYRK1A0.34166672
98PRKCI0.33033506
99GRK70.33000439
100PRKCA0.32364123

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.09030182
2Parkinsons disease_Homo sapiens_hsa050122.50439193
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40942149
4Phototransduction_Homo sapiens_hsa047442.36049274
5Protein export_Homo sapiens_hsa030602.31439567
6Homologous recombination_Homo sapiens_hsa034402.11722136
7Butanoate metabolism_Homo sapiens_hsa006502.10517210
8Selenocompound metabolism_Homo sapiens_hsa004502.10382847
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08446383
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.07013363
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03619831
12RNA polymerase_Homo sapiens_hsa030202.03060036
13Nitrogen metabolism_Homo sapiens_hsa009101.98603771
14Nicotine addiction_Homo sapiens_hsa050331.96742794
15Basal transcription factors_Homo sapiens_hsa030221.93575105
16Linoleic acid metabolism_Homo sapiens_hsa005911.92657422
17Fanconi anemia pathway_Homo sapiens_hsa034601.87119403
18Huntingtons disease_Homo sapiens_hsa050161.75988822
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75462180
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74808116
21Propanoate metabolism_Homo sapiens_hsa006401.68895108
22Cardiac muscle contraction_Homo sapiens_hsa042601.68733563
23Ribosome_Homo sapiens_hsa030101.62437636
24Caffeine metabolism_Homo sapiens_hsa002321.60233492
25Alzheimers disease_Homo sapiens_hsa050101.58720578
26RNA degradation_Homo sapiens_hsa030181.55405129
27Tryptophan metabolism_Homo sapiens_hsa003801.46646940
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45011291
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35488131
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.33020510
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30658332
32Taste transduction_Homo sapiens_hsa047421.28617288
33One carbon pool by folate_Homo sapiens_hsa006701.28421779
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28134718
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27443335
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24146591
37Ether lipid metabolism_Homo sapiens_hsa005651.22686864
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19148261
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16595254
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14802382
41Retinol metabolism_Homo sapiens_hsa008301.13339735
42Non-homologous end-joining_Homo sapiens_hsa034501.12300516
43Chemical carcinogenesis_Homo sapiens_hsa052041.11332439
44Proteasome_Homo sapiens_hsa030501.11192538
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.09482750
46Peroxisome_Homo sapiens_hsa041461.07624634
47Olfactory transduction_Homo sapiens_hsa047401.06763239
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00865082
49Regulation of autophagy_Homo sapiens_hsa041401.00490605
50Mismatch repair_Homo sapiens_hsa034300.97883291
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95048137
52Morphine addiction_Homo sapiens_hsa050320.93985959
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.90270351
54beta-Alanine metabolism_Homo sapiens_hsa004100.90177701
55Purine metabolism_Homo sapiens_hsa002300.88240189
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87931217
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86451899
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83028313
59GABAergic synapse_Homo sapiens_hsa047270.81690346
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81240442
61ABC transporters_Homo sapiens_hsa020100.80191316
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79116457
63Serotonergic synapse_Homo sapiens_hsa047260.76712662
64Collecting duct acid secretion_Homo sapiens_hsa049660.74837070
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74120916
66Insulin secretion_Homo sapiens_hsa049110.73495372
67Arachidonic acid metabolism_Homo sapiens_hsa005900.73363690
68Vitamin digestion and absorption_Homo sapiens_hsa049770.73290505
69Nucleotide excision repair_Homo sapiens_hsa034200.72708870
70Metabolic pathways_Homo sapiens_hsa011000.71778457
71Circadian rhythm_Homo sapiens_hsa047100.69665937
72Fat digestion and absorption_Homo sapiens_hsa049750.68776916
73Circadian entrainment_Homo sapiens_hsa047130.68163293
74Fatty acid degradation_Homo sapiens_hsa000710.65455194
75Pyrimidine metabolism_Homo sapiens_hsa002400.65177925
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63658606
77RNA transport_Homo sapiens_hsa030130.61579716
78Mineral absorption_Homo sapiens_hsa049780.60918279
79Glutamatergic synapse_Homo sapiens_hsa047240.60819760
80Sulfur metabolism_Homo sapiens_hsa009200.58307148
81Hedgehog signaling pathway_Homo sapiens_hsa043400.54937495
82Ovarian steroidogenesis_Homo sapiens_hsa049130.53892781
83Fatty acid elongation_Homo sapiens_hsa000620.53656056
84Histidine metabolism_Homo sapiens_hsa003400.53328451
85Fatty acid metabolism_Homo sapiens_hsa012120.53128559
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52536109
87Steroid biosynthesis_Homo sapiens_hsa001000.51714734
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50283362
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48736598
90Basal cell carcinoma_Homo sapiens_hsa052170.48377326
91Pyruvate metabolism_Homo sapiens_hsa006200.48040810
92Folate biosynthesis_Homo sapiens_hsa007900.46752781
93Salivary secretion_Homo sapiens_hsa049700.43952174
94Glycerolipid metabolism_Homo sapiens_hsa005610.42039367
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41500668
96Calcium signaling pathway_Homo sapiens_hsa040200.41442860
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39367308
98Arginine and proline metabolism_Homo sapiens_hsa003300.39078796
99Cocaine addiction_Homo sapiens_hsa050300.37199482
100Dopaminergic synapse_Homo sapiens_hsa047280.36444122

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »