ZNF211

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. This protein may play a role in developmental processes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)4.22899245
2positive regulation of growth hormone secretion (GO:0060124)4.19034768
3eosinophil chemotaxis (GO:0048245)4.15397057
4positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.01655384
5mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.01655384
6monoubiquitinated protein deubiquitination (GO:0035520)3.96912577
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.82336326
8negative regulation of cell killing (GO:0031342)3.82336326
9negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.81843999
10eosinophil migration (GO:0072677)3.71956744
11negative regulation of cAMP-mediated signaling (GO:0043951)3.61085653
12regulation of retinoic acid receptor signaling pathway (GO:0048385)3.52432612
13negative regulation of interleukin-1 beta production (GO:0032691)3.48486381
14positive regulation of T cell cytokine production (GO:0002726)3.44543015
15neural tube formation (GO:0001841)3.38549253
16phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.36665476
17pyrimidine nucleobase catabolic process (GO:0006208)3.34297561
18nucleobase catabolic process (GO:0046113)3.32831078
19positive regulation of granulocyte differentiation (GO:0030854)3.19569606
20negative T cell selection (GO:0043383)3.16913737
21olfactory bulb development (GO:0021772)3.11510993
22negative regulation of interleukin-1 production (GO:0032692)3.08884642
23cellular response to ethanol (GO:0071361)3.05311058
24Golgi to endosome transport (GO:0006895)3.04109189
25tolerance induction (GO:0002507)3.03092138
26protein K11-linked deubiquitination (GO:0035871)3.01897835
27head development (GO:0060322)3.00445692
28negative thymic T cell selection (GO:0045060)2.99995547
29regulation of T cell tolerance induction (GO:0002664)2.98384910
30glycosphingolipid biosynthetic process (GO:0006688)2.98155482
31negative regulation of circadian rhythm (GO:0042754)2.96655293
32regulation of growth hormone secretion (GO:0060123)2.96282641
33regulation of cilium movement (GO:0003352)2.94101784
34T cell migration (GO:0072678)2.89776012
35RNA destabilization (GO:0050779)2.89156410
36regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.86967399
37negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.85647874
38negative regulation of T-helper cell differentiation (GO:0045623)2.85647874
39regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.85342340
40positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.85342340
41growth hormone secretion (GO:0030252)2.84538081
42acrosome assembly (GO:0001675)2.83891320
43positive regulation of mitochondrial fission (GO:0090141)2.83647080
44neuron cell-cell adhesion (GO:0007158)2.83046640
45myeloid leukocyte mediated immunity (GO:0002444)2.82922578
46regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.82204073
47positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.82204073
48histone H2A acetylation (GO:0043968)2.77857161
49regulation of B cell receptor signaling pathway (GO:0050855)2.75823027
50neutrophil mediated immunity (GO:0002446)2.75716948
51histone H3-K4 trimethylation (GO:0080182)2.73089655
52negative regulation of lymphocyte mediated immunity (GO:0002707)2.72693952
53calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.70914983
54intraciliary transport (GO:0042073)2.68766288
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.68649404
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68566343
57regulation of tolerance induction (GO:0002643)2.68228830
58inositol phosphate catabolic process (GO:0071545)2.67728026
59cellular extravasation (GO:0045123)2.67182409
60negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66284987
61histone mRNA catabolic process (GO:0071044)2.60162746
62negative regulation of JUN kinase activity (GO:0043508)2.60060064
63positive regulation of tolerance induction (GO:0002645)2.58585294
64positive regulation of cAMP-mediated signaling (GO:0043950)2.56582476
65positive regulation of gamma-delta T cell activation (GO:0046645)2.55785635
66negative regulation of DNA recombination (GO:0045910)2.54595384
67axoneme assembly (GO:0035082)2.52588808
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.52479562
69DNA integration (GO:0015074)2.51808172
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.50160411
71platelet dense granule organization (GO:0060155)2.48611945
72histone deubiquitination (GO:0016578)2.47289680
73dosage compensation (GO:0007549)2.45181264
74regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.45006969
75mRNA splice site selection (GO:0006376)2.44788291
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.44428722
77regulation of glucocorticoid secretion (GO:2000849)2.43868690
78protein-cofactor linkage (GO:0018065)2.42706651
79positive T cell selection (GO:0043368)2.42251217
80regulation of translation in response to stress (GO:0043555)2.41194210
81glial cell proliferation (GO:0014009)2.40783305
82positive regulation of mRNA processing (GO:0050685)2.39952197
83regulation of mRNA splicing, via spliceosome (GO:0048024)2.39872488
84negative regulation of B cell mediated immunity (GO:0002713)2.37286394
85negative regulation of immunoglobulin mediated immune response (GO:0002890)2.37286394
86regulation of T cell cytokine production (GO:0002724)2.36843194
87CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.36230613
88germinal center formation (GO:0002467)2.36160372
89regulation of interleukin-6 biosynthetic process (GO:0045408)2.35862344
90protein localization to cilium (GO:0061512)2.35634288
91regulation of T cell receptor signaling pathway (GO:0050856)2.35434446
92regulation of lymphocyte chemotaxis (GO:1901623)2.35427321
93phosphorylated carbohydrate dephosphorylation (GO:0046838)2.35195683
94inositol phosphate dephosphorylation (GO:0046855)2.35195683
95folic acid transport (GO:0015884)2.32677807
96anterograde synaptic vesicle transport (GO:0048490)2.32601373
97regulation of interferon-beta biosynthetic process (GO:0045357)2.31816243
98regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.30986767
99negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.30557456
100positive regulation of mRNA catabolic process (GO:0061014)2.30517483

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela4.04412523
2POU3F2_20337985_ChIP-ChIP_501MEL_Human2.93174935
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.85112041
4NOTCH1_21737748_ChIP-Seq_TLL_Human2.84548336
5IGF1R_20145208_ChIP-Seq_DFB_Human2.79489469
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.51494747
7TAF15_26573619_Chip-Seq_HEK293_Human2.50758341
8GBX2_23144817_ChIP-Seq_PC3_Human2.46949060
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40440492
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23299021
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.22386583
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.19793384
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.17635561
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08957234
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89882997
16IRF8_21731497_ChIP-ChIP_J774_Mouse1.89536856
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87049834
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84717053
19EWS_26573619_Chip-Seq_HEK293_Human1.78531601
20VDR_22108803_ChIP-Seq_LS180_Human1.78412865
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.77365331
22CIITA_25753668_ChIP-Seq_RAJI_Human1.71880301
23RUNX_20019798_ChIP-Seq_JUKART_Human1.67320531
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67293611
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64718034
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60715787
27VDR_23849224_ChIP-Seq_CD4+_Human1.60241450
28IRF1_19129219_ChIP-ChIP_H3396_Human1.59946681
29FUS_26573619_Chip-Seq_HEK293_Human1.58467004
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56519880
31CBP_20019798_ChIP-Seq_JUKART_Human1.56519880
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.54382254
33* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53097707
34ELK1_19687146_ChIP-ChIP_HELA_Human1.49080544
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48617376
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47647229
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47263320
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45972480
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44403215
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43737258
41RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.43411306
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42216506
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41807841
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41717243
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41457335
46P300_19829295_ChIP-Seq_ESCs_Human1.40390747
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39262392
48SMAD4_21799915_ChIP-Seq_A2780_Human1.37274950
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37274154
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.35923728
51* GATA3_27048872_Chip-Seq_THYMUS_Human1.35039948
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34648300
53MYB_26560356_Chip-Seq_TH2_Human1.32046434
54GATA3_26560356_Chip-Seq_TH2_Human1.31942662
55ER_23166858_ChIP-Seq_MCF-7_Human1.29638054
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.29285592
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26501625
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25337909
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23159661
60STAT3_23295773_ChIP-Seq_U87_Human1.22966086
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22917138
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22834356
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.22768153
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22291648
65TP53_22573176_ChIP-Seq_HFKS_Human1.22160630
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.19578482
67BCAT_22108803_ChIP-Seq_LS180_Human1.19238714
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.19029530
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19002669
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17525127
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13790699
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13790699
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13497792
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12700308
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11355863
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.11300639
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11188939
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.10866595
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08470022
80RUNX2_22187159_ChIP-Seq_PCA_Human1.07707749
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06794847
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06273270
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06177876
84VDR_24787735_ChIP-Seq_THP-1_Human1.05999531
85AR_25329375_ChIP-Seq_VCAP_Human1.04741319
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03912447
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03120390
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02690364
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.01913248
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01551808
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00176348
92KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98730416
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.98370729
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98096394
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.97562293
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.96237272
97TCF4_22108803_ChIP-Seq_LS180_Human0.96117419
98TCF4_23295773_ChIP-Seq_U87_Human0.95389159
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.94578095
100FOXP3_21729870_ChIP-Seq_TREG_Human0.94277539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.21160972
2MP0003724_increased_susceptibility_to2.90433053
3MP0008877_abnormal_DNA_methylation2.82936947
4MP0001984_abnormal_olfaction2.76411686
5MP0003122_maternal_imprinting2.47940931
6MP0001986_abnormal_taste_sensitivity2.41448908
7MP0003787_abnormal_imprinting2.39160267
8MP0008995_early_reproductive_senescence2.23402800
9MP0000465_gastrointestinal_hemorrhage2.14061254
10MP0005075_abnormal_melanosome_morpholog2.13639406
11MP0003646_muscle_fatigue1.93414154
12MP0005394_taste/olfaction_phenotype1.92385275
13MP0005499_abnormal_olfactory_system1.92385275
14MP0001835_abnormal_antigen_presentation1.90891684
15MP0005084_abnormal_gallbladder_morpholo1.88667673
16MP0003121_genomic_imprinting1.80406240
17MP0005671_abnormal_response_to1.77521882
18MP0005367_renal/urinary_system_phenotyp1.73179368
19MP0000516_abnormal_urinary_system1.73179368
20MP0002736_abnormal_nociception_after1.71443786
21MP0004381_abnormal_hair_follicle1.64853281
22MP0008789_abnormal_olfactory_epithelium1.64470673
23MP0001968_abnormal_touch/_nociception1.61865075
24MP0001800_abnormal_humoral_immune1.58663646
25MP0005000_abnormal_immune_tolerance1.58223310
26MP0002638_abnormal_pupillary_reflex1.54871809
27MP0006054_spinal_hemorrhage1.53349169
28MP0002009_preneoplasia1.50401357
29MP0002723_abnormal_immune_serum1.48893680
30MP0008260_abnormal_autophagy1.45902585
31MP0002735_abnormal_chemical_nociception1.44493074
32MP0005645_abnormal_hypothalamus_physiol1.44282668
33MP0008058_abnormal_DNA_repair1.43942185
34MP0002420_abnormal_adaptive_immunity1.42891109
35MP0001819_abnormal_immune_cell1.41415067
36MP0003221_abnormal_cardiomyocyte_apopto1.39503657
37MP0002277_abnormal_respiratory_mucosa1.39118199
38MP0009785_altered_susceptibility_to1.34998766
39MP0002148_abnormal_hypersensitivity_rea1.34808969
40MP0003172_abnormal_lysosome_physiology1.34464729
41MP0003195_calcinosis1.32601949
42MP0002452_abnormal_antigen_presenting1.32365798
43MP0003436_decreased_susceptibility_to1.32015521
44MP0004142_abnormal_muscle_tone1.31596959
45MP0002419_abnormal_innate_immunity1.27572690
46MP0006072_abnormal_retinal_apoptosis1.20726214
47MP0005310_abnormal_salivary_gland1.20485123
48MP0001188_hyperpigmentation1.19938508
49MP0003890_abnormal_embryonic-extraembry1.18635997
50MP0005248_abnormal_Harderian_gland1.18020834
51MP0003880_abnormal_central_pattern1.16872329
52MP0005253_abnormal_eye_physiology1.16860146
53MP0006276_abnormal_autonomic_nervous1.16798445
54MP0001501_abnormal_sleep_pattern1.16738694
55MP0000372_irregular_coat_pigmentation1.11477535
56MP0005387_immune_system_phenotype1.11278267
57MP0001790_abnormal_immune_system1.11278267
58MP0000689_abnormal_spleen_morphology1.09810452
59MP0009764_decreased_sensitivity_to1.09677124
60MP0000716_abnormal_immune_system1.09430859
61MP0002138_abnormal_hepatobiliary_system1.08899515
62MP0004270_analgesia1.07974008
63MP0002398_abnormal_bone_marrow1.06353695
64MP0005025_abnormal_response_to1.06120027
65MP0001502_abnormal_circadian_rhythm1.05259330
66MP0001529_abnormal_vocalization1.01197382
67MP0002722_abnormal_immune_system0.93135329
68MP0003303_peritoneal_inflammation0.93111502
69MP0002132_abnormal_respiratory_system0.92045992
70MP0005187_abnormal_penis_morphology0.91505124
71MP0001845_abnormal_inflammatory_respons0.90796283
72MP0005167_abnormal_blood-brain_barrier0.90440193
73MP0003763_abnormal_thymus_physiology0.89524099
74MP0000703_abnormal_thymus_morphology0.89357494
75MP0005551_abnormal_eye_electrophysiolog0.89337456
76MP0004924_abnormal_behavior0.87812354
77MP0005386_behavior/neurological_phenoty0.87812354
78MP0009765_abnormal_xenobiotic_induced0.85829603
79MP0000569_abnormal_digit_pigmentation0.84536327
80MP0002272_abnormal_nervous_system0.83868352
81MP0008057_abnormal_DNA_replication0.83107054
82MP0000685_abnormal_immune_system0.79783875
83MP0005535_abnormal_body_temperature0.79517890
84MP0002751_abnormal_autonomic_nervous0.78402194
85MP0004215_abnormal_myocardial_fiber0.76996208
86MP0006292_abnormal_olfactory_placode0.73745396
87MP0000647_abnormal_sebaceous_gland0.73286536
88MP0002429_abnormal_blood_cell0.73247342
89MP0005464_abnormal_platelet_physiology0.73176187
90MP0001486_abnormal_startle_reflex0.72349470
91MP0003786_premature_aging0.72321535
92MP0003656_abnormal_erythrocyte_physiolo0.72165378
93MP0005646_abnormal_pituitary_gland0.71854815
94MP0009333_abnormal_splenocyte_physiolog0.71785956
95MP0002733_abnormal_thermal_nociception0.71690490
96MP0001929_abnormal_gametogenesis0.70984000
97MP0000604_amyloidosis0.70975670
98MP0000631_abnormal_neuroendocrine_gland0.70219788
99MP0004133_heterotaxia0.68776513
100MP0001970_abnormal_pain_threshold0.67371894

Predicted human phenotypes

RankGene SetZ-score
1Congenital primary aphakia (HP:0007707)3.17451741
2Chronic hepatic failure (HP:0100626)3.13831332
3Gait imbalance (HP:0002141)3.10693285
4Amyotrophic lateral sclerosis (HP:0007354)3.10690140
5Medial flaring of the eyebrow (HP:0010747)3.09440528
6Progressive inability to walk (HP:0002505)3.08710495
7Nephrogenic diabetes insipidus (HP:0009806)2.98592561
8Broad alveolar ridges (HP:0000187)2.81129352
9Polyphagia (HP:0002591)2.76041901
10Intestinal atresia (HP:0011100)2.73548290
11Pancreatic cysts (HP:0001737)2.72366314
12Hepatoblastoma (HP:0002884)2.71965630
13Hyperventilation (HP:0002883)2.70094778
14True hermaphroditism (HP:0010459)2.68188942
15Excessive salivation (HP:0003781)2.67616254
16Drooling (HP:0002307)2.64608977
17Stomatitis (HP:0010280)2.62454904
18Genital tract atresia (HP:0001827)2.62092570
19Mediastinal lymphadenopathy (HP:0100721)2.53648567
20Oligodactyly (hands) (HP:0001180)2.47522595
21Vaginal atresia (HP:0000148)2.47168704
22Absent speech (HP:0001344)2.45087977
23Pancreatic fibrosis (HP:0100732)2.41193798
24Abnormality of the labia minora (HP:0012880)2.36182159
25Severe combined immunodeficiency (HP:0004430)2.32611311
26Progressive microcephaly (HP:0000253)2.31416394
27Hemiparesis (HP:0001269)2.31042090
28Lissencephaly (HP:0001339)2.30880385
29Widely spaced teeth (HP:0000687)2.30631391
30Abnormality of eosinophils (HP:0001879)2.30549151
31Failure to thrive in infancy (HP:0001531)2.29725464
32Specific learning disability (HP:0001328)2.25241454
33Abnormal hair whorl (HP:0010721)2.21984155
34Generalized myoclonic seizures (HP:0002123)2.13417041
35Inability to walk (HP:0002540)2.12426578
36Dyskinesia (HP:0100660)2.11195743
37Tubulointerstitial nephritis (HP:0001970)2.10339562
38Limb dystonia (HP:0002451)2.09988087
39Recurrent bacterial skin infections (HP:0005406)2.08228745
40Recurrent abscess formation (HP:0002722)2.05849629
41Volvulus (HP:0002580)2.05215167
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.05133576
43Leukocytosis (HP:0001974)2.03939658
44Thyroiditis (HP:0100646)2.00972777
45Poor coordination (HP:0002370)2.00598253
46Eosinophilia (HP:0001880)1.99499313
47Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.96724239
48Short 1st metacarpal (HP:0010034)1.96724239
49Abnormality of midbrain morphology (HP:0002418)1.95192674
50Molar tooth sign on MRI (HP:0002419)1.95192674
51Pachygyria (HP:0001302)1.92947754
52Abnormality of the alveolar ridges (HP:0006477)1.91940723
53Combined immunodeficiency (HP:0005387)1.91915036
54Curly hair (HP:0002212)1.91910471
55Peripheral hypomyelination (HP:0007182)1.91783437
56Decreased testicular size (HP:0008734)1.91198524
57Optic neuritis (HP:0100653)1.90438864
58Retrobulbar optic neuritis (HP:0100654)1.90438864
59Abnormality of macrophages (HP:0004311)1.90395831
60Broad foot (HP:0001769)1.89843904
61Atrophy/Degeneration involving motor neurons (HP:0007373)1.87634853
62Decreased central vision (HP:0007663)1.87203385
63Cortical dysplasia (HP:0002539)1.87050882
64IgG deficiency (HP:0004315)1.86810528
65Esotropia (HP:0000565)1.86022499
66Abnormal rod and cone electroretinograms (HP:0008323)1.85989891
67Alveolar cell carcinoma (HP:0006519)1.85702575
68Attenuation of retinal blood vessels (HP:0007843)1.85180502
69Recurrent fungal infections (HP:0002841)1.84866041
70Elevated erythrocyte sedimentation rate (HP:0003565)1.83096188
71Short tibia (HP:0005736)1.82829063
72Progressive cerebellar ataxia (HP:0002073)1.82114393
73Gastrointestinal infarctions (HP:0005244)1.81474244
74Septo-optic dysplasia (HP:0100842)1.81321629
75Postaxial hand polydactyly (HP:0001162)1.80343561
76Oligodactyly (HP:0012165)1.79820457
77Occipital encephalocele (HP:0002085)1.79598845
78Bile duct proliferation (HP:0001408)1.79308677
79Abnormal biliary tract physiology (HP:0012439)1.79308677
80Narrow forehead (HP:0000341)1.79148372
81Neoplasm of the tracheobronchial system (HP:0100552)1.77766251
82Abnormality of the metopic suture (HP:0005556)1.76665526
83Ependymoma (HP:0002888)1.76080535
84Hip dysplasia (HP:0001385)1.76043670
85Oculomotor apraxia (HP:0000657)1.74796706
86Abnormality of salivation (HP:0100755)1.74756560
87Anencephaly (HP:0002323)1.74575198
88Neonatal respiratory distress (HP:0002643)1.73761957
89Absent eyebrow (HP:0002223)1.73330266
90Thyroid-stimulating hormone excess (HP:0002925)1.72581471
91Aplasia/Hypoplasia of the tibia (HP:0005772)1.72394895
92Mutism (HP:0002300)1.71668670
93Myositis (HP:0100614)1.71288077
94Pustule (HP:0200039)1.70806893
95Stomach cancer (HP:0012126)1.69897034
96Eczematoid dermatitis (HP:0000976)1.69262299
97Granulocytopenia (HP:0001913)1.69015908
98Pulmonary infiltrates (HP:0002113)1.68394520
99Submucous cleft hard palate (HP:0000176)1.68371142
100Broad-based gait (HP:0002136)1.68063056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.61160874
2ERBB32.89833446
3BCR2.76574600
4MAP3K42.56950628
5BRD42.52038380
6WNK32.49345238
7AKT32.36139415
8TRIM282.34555544
9TXK2.04457050
10BLK1.95268228
11SRPK11.87055100
12MAP4K11.79168106
13SIK31.75824287
14MAP2K71.68862203
15EPHA31.60179548
16MAP3K141.55587181
17MARK31.52115050
18FRK1.51653634
19EIF2AK31.49694264
20PAK31.49425766
21NUAK11.49390003
22IKBKE1.47945486
23CASK1.42790590
24SIK21.36547104
25CSNK1G31.36262169
26CSNK1G21.33304787
27PINK11.27130664
28PLK21.25697314
29ADRBK21.23547795
30TNK21.23279762
31CSNK1G11.22687175
32CSNK1A1L1.21807621
33CAMKK21.15351410
34EPHB11.11464448
35GRK11.08911593
36KSR11.08433834
37PRKCQ1.06163546
38MKNK21.00915664
39IKBKB1.00831555
40MAPK130.99573225
41MKNK10.95103588
42MAP3K50.93966342
43DYRK1B0.93901769
44PIK3CG0.92982206
45TAOK30.90682692
46IRAK10.90112994
47FLT30.89172639
48NLK0.89096988
49NTRK20.85328662
50LYN0.83167097
51JAK10.80933612
52TBK10.80295009
53BRSK20.79096499
54MARK10.78936257
55SYK0.78470805
56ITK0.78465047
57SGK20.76888946
58YES10.76526130
59RAF10.74917574
60PLK40.74304760
61CHUK0.71182959
62DYRK30.70738439
63TYK20.66515627
64DYRK1A0.65083172
65HCK0.65063147
66PRKCE0.64489476
67FGR0.64381393
68STK100.63906329
69CSK0.62675764
70FES0.62461107
71GRK60.61131146
72DYRK20.60388146
73IRAK40.59993428
74LCK0.59639216
75MAP2K40.58464949
76BTK0.57224493
77CDK60.57079832
78CDK190.55547296
79SGK4940.54363930
80SGK2230.54363930
81JAK20.53759903
82PIM10.53100025
83RPS6KB10.52311182
84EGFR0.51788190
85EIF2AK20.48954084
86TEC0.48169370
87ERBB40.46757281
88PRKCZ0.46127020
89IRAK20.46065200
90MAPK70.45900386
91RPS6KA40.44970524
92OBSCN0.44222587
93PAK60.43359298
94PKN20.42395439
95CSNK1D0.41589783
96MUSK0.41064478
97PRKCG0.39827846
98GRK70.38652922
99CSNK1A10.38376941
100NEK60.37724733

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.38853616
2Basal transcription factors_Homo sapiens_hsa030222.13644698
3Graft-versus-host disease_Homo sapiens_hsa053321.97417532
4Steroid biosynthesis_Homo sapiens_hsa001001.90106698
5Primary immunodeficiency_Homo sapiens_hsa053401.89347930
6Non-homologous end-joining_Homo sapiens_hsa034501.84744489
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84459771
8Regulation of autophagy_Homo sapiens_hsa041401.83454959
9Type I diabetes mellitus_Homo sapiens_hsa049401.80818692
10Measles_Homo sapiens_hsa051621.75267037
11Allograft rejection_Homo sapiens_hsa053301.68624364
12Staphylococcus aureus infection_Homo sapiens_hsa051501.64975954
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.62370545
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59897062
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58958046
16Circadian rhythm_Homo sapiens_hsa047101.58069929
17Herpes simplex infection_Homo sapiens_hsa051681.55862827
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55513093
19Autoimmune thyroid disease_Homo sapiens_hsa053201.54252866
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53006294
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48954377
22Chemokine signaling pathway_Homo sapiens_hsa040621.48454691
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45950830
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45497010
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.45383745
26Osteoclast differentiation_Homo sapiens_hsa043801.44391531
27Nicotine addiction_Homo sapiens_hsa050331.42682134
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41458827
29T cell receptor signaling pathway_Homo sapiens_hsa046601.36752850
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35864794
31Selenocompound metabolism_Homo sapiens_hsa004501.23915538
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19858499
33Legionellosis_Homo sapiens_hsa051341.15601020
34Leishmaniasis_Homo sapiens_hsa051401.12996966
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.10109174
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10067322
37RNA degradation_Homo sapiens_hsa030181.09802475
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08194379
39Taste transduction_Homo sapiens_hsa047421.05707534
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05663430
41Tuberculosis_Homo sapiens_hsa051521.05021822
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00418372
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00385809
44Hematopoietic cell lineage_Homo sapiens_hsa046400.99722363
45RNA polymerase_Homo sapiens_hsa030200.99519533
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98190709
47B cell receptor signaling pathway_Homo sapiens_hsa046620.96799753
48Inositol phosphate metabolism_Homo sapiens_hsa005620.95189051
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94249924
50Protein export_Homo sapiens_hsa030600.94006371
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.93462741
52Colorectal cancer_Homo sapiens_hsa052100.91945823
53Phagosome_Homo sapiens_hsa041450.91395452
54Butanoate metabolism_Homo sapiens_hsa006500.85793043
55Shigellosis_Homo sapiens_hsa051310.84726154
56Sphingolipid metabolism_Homo sapiens_hsa006000.84462836
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84071465
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83651868
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82331973
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82320858
61TNF signaling pathway_Homo sapiens_hsa046680.82128897
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81712557
63Hepatitis C_Homo sapiens_hsa051600.81113352
64Rheumatoid arthritis_Homo sapiens_hsa053230.80141206
65Influenza A_Homo sapiens_hsa051640.79279021
66FoxO signaling pathway_Homo sapiens_hsa040680.79252684
67GABAergic synapse_Homo sapiens_hsa047270.79144259
68Antigen processing and presentation_Homo sapiens_hsa046120.78265868
69Phototransduction_Homo sapiens_hsa047440.77764322
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74632482
71Collecting duct acid secretion_Homo sapiens_hsa049660.73573797
72Fatty acid elongation_Homo sapiens_hsa000620.72130339
73Viral myocarditis_Homo sapiens_hsa054160.69917331
74Epstein-Barr virus infection_Homo sapiens_hsa051690.68642258
75Hepatitis B_Homo sapiens_hsa051610.68384986
76Asthma_Homo sapiens_hsa053100.67406148
77Acute myeloid leukemia_Homo sapiens_hsa052210.66639504
78Prolactin signaling pathway_Homo sapiens_hsa049170.66616987
79mRNA surveillance pathway_Homo sapiens_hsa030150.66224098
80Morphine addiction_Homo sapiens_hsa050320.64366900
81Viral carcinogenesis_Homo sapiens_hsa052030.58817649
82Endometrial cancer_Homo sapiens_hsa052130.58809669
83ABC transporters_Homo sapiens_hsa020100.55294906
84Toxoplasmosis_Homo sapiens_hsa051450.54216306
85mTOR signaling pathway_Homo sapiens_hsa041500.53652584
86Linoleic acid metabolism_Homo sapiens_hsa005910.52607935
87Fanconi anemia pathway_Homo sapiens_hsa034600.52336540
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52120085
89Long-term depression_Homo sapiens_hsa047300.50968723
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50342762
91Apoptosis_Homo sapiens_hsa042100.49823248
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.49690974
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47227219
94Olfactory transduction_Homo sapiens_hsa047400.47100946
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47015130
96Dorso-ventral axis formation_Homo sapiens_hsa043200.46823705
97Lysosome_Homo sapiens_hsa041420.46713399
98Ether lipid metabolism_Homo sapiens_hsa005650.44475566
99Spliceosome_Homo sapiens_hsa030400.44432624
100p53 signaling pathway_Homo sapiens_hsa041150.43220202

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