ZNF212

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of viral latency (GO:0019043)4.04854158
2negative regulation of DNA-templated transcription, elongation (GO:0032785)3.90143908
3cellular response to nitric oxide (GO:0071732)3.88200844
4positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.85944249
5neutrophil activation involved in immune response (GO:0002283)3.84504553
6autophagic vacuole fusion (GO:0000046)3.84003401
7histone H3-K36 demethylation (GO:0070544)3.83112254
8negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.74084986
9regulation of NFAT protein import into nucleus (GO:0051532)3.68498442
10positive regulation of protein homooligomerization (GO:0032464)3.55931102
11negative regulation of cell killing (GO:0031342)3.47287850
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.47287850
13poly(A)+ mRNA export from nucleus (GO:0016973)3.43683215
14DNA unwinding involved in DNA replication (GO:0006268)3.39829287
153-UTR-mediated mRNA stabilization (GO:0070935)3.31894783
16peptidyl-arginine omega-N-methylation (GO:0035247)3.29045230
17formation of translation preinitiation complex (GO:0001731)3.24350745
18DNA synthesis involved in DNA repair (GO:0000731)3.22574254
19NIK/NF-kappaB signaling (GO:0038061)3.21721341
20metallo-sulfur cluster assembly (GO:0031163)3.15737408
21iron-sulfur cluster assembly (GO:0016226)3.15737408
22cellular response to virus (GO:0098586)3.14835551
23regulation of interferon-beta biosynthetic process (GO:0045357)3.08906426
24regulation of chromatin binding (GO:0035561)3.07273584
25snRNA metabolic process (GO:0016073)3.07189010
26negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.06168254
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98968893
28intracellular estrogen receptor signaling pathway (GO:0030520)2.93560185
29organelle membrane fusion (GO:0090174)2.90224627
30response to nitric oxide (GO:0071731)2.89895516
31stress granule assembly (GO:0034063)2.87079578
32snRNA processing (GO:0016180)2.85023824
33tumor necrosis factor-mediated signaling pathway (GO:0033209)2.82419308
34response to peptidoglycan (GO:0032494)2.80896627
35peptidyl-arginine N-methylation (GO:0035246)2.76841502
36peptidyl-arginine methylation (GO:0018216)2.76841502
37RNA destabilization (GO:0050779)2.74652260
38GDP-mannose metabolic process (GO:0019673)2.74199030
39protein localization to microtubule (GO:0035372)2.74133268
40histone arginine methylation (GO:0034969)2.71086691
41negative regulation of histone methylation (GO:0031061)2.69616084
42Golgi transport vesicle coating (GO:0048200)2.69319395
43COPI coating of Golgi vesicle (GO:0048205)2.69319395
44cytoplasmic sequestering of transcription factor (GO:0042994)2.68808409
45DNA topological change (GO:0006265)2.67409091
46pyrimidine nucleotide catabolic process (GO:0006244)2.66688606
47maternal placenta development (GO:0001893)2.65829687
48cellular response to reactive nitrogen species (GO:1902170)2.64444958
49negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.63746696
50protoporphyrinogen IX biosynthetic process (GO:0006782)2.63162198
51mitotic chromosome condensation (GO:0007076)2.63007091
52regulation of autophagic vacuole assembly (GO:2000785)2.61876917
53spliceosomal tri-snRNP complex assembly (GO:0000244)2.61381183
54dosage compensation (GO:0007549)2.61277808
55negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.60554962
56ribosomal small subunit assembly (GO:0000028)2.60478961
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56226257
58cellular response to interleukin-4 (GO:0071353)2.55877108
59histone H4 deacetylation (GO:0070933)2.55420331
60positive regulation of T cell cytokine production (GO:0002726)2.54154509
61base-excision repair, AP site formation (GO:0006285)2.53898385
62phagocytosis, engulfment (GO:0006911)2.52892366
63negative regulation of innate immune response (GO:0045824)2.51776422
64viral protein processing (GO:0019082)2.50673295
65regulation of type I interferon-mediated signaling pathway (GO:0060338)2.50489921
66regulation of vacuole organization (GO:0044088)2.49088591
67synaptonemal complex assembly (GO:0007130)2.48575776
68positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.46039791
69DNA strand elongation involved in DNA replication (GO:0006271)2.44115787
70nucleosome disassembly (GO:0006337)2.43443948
71protein-DNA complex disassembly (GO:0032986)2.43443948
72maturation of 5.8S rRNA (GO:0000460)2.42348436
73histone H3 deacetylation (GO:0070932)2.41543445
74protoporphyrinogen IX metabolic process (GO:0046501)2.41253625
75virion assembly (GO:0019068)2.38985527
76UV protection (GO:0009650)2.38545190
77regulation of histone H3-K9 methylation (GO:0051570)2.38247772
78rRNA transcription (GO:0009303)2.37099432
79heterochromatin organization (GO:0070828)2.36518910
80DNA strand elongation (GO:0022616)2.36452826
81histone H3-K9 demethylation (GO:0033169)2.36363804
82positive regulation of receptor biosynthetic process (GO:0010870)2.34552121
83ncRNA 3-end processing (GO:0043628)2.34501794
84regulation of transcription from RNA polymerase I promoter (GO:0006356)2.33721503
85response to interleukin-4 (GO:0070670)2.33214689
86response to muramyl dipeptide (GO:0032495)2.32622836
87mannosylation (GO:0097502)2.31633876
88somatic hypermutation of immunoglobulin genes (GO:0016446)2.30389188
89somatic diversification of immune receptors via somatic mutation (GO:0002566)2.30389188
90DNA replication initiation (GO:0006270)2.29078069
91negative regulation of type I interferon production (GO:0032480)2.28393351
92ribosome biogenesis (GO:0042254)2.28059790
93regulation of defense response to virus by host (GO:0050691)2.27286640
94histone lysine demethylation (GO:0070076)2.25835618
95IMP metabolic process (GO:0046040)2.25368655
96regulation of protein homodimerization activity (GO:0043496)2.25127461
97regulation of chemokine biosynthetic process (GO:0045073)2.23713708
98T cell apoptotic process (GO:0070231)2.22919176
99intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.22648984
100DNA methylation involved in gamete generation (GO:0043046)2.22435250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.05382436
2MYC_22102868_ChIP-Seq_BL_Human2.86549290
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.72248894
4VDR_21846776_ChIP-Seq_THP-1_Human2.59870934
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53252080
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.53151290
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.45019860
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.26103975
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23398779
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13043865
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03981442
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97572826
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95918828
14CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.95016472
15THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94209697
16MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88648382
17CIITA_25753668_ChIP-Seq_RAJI_Human1.86841313
18XRN2_22483619_ChIP-Seq_HELA_Human1.80479380
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.79479420
20MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72266955
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71442308
22GABP_19822575_ChIP-Seq_HepG2_Human1.69533965
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66248289
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66220053
25MAF_26560356_Chip-Seq_TH1_Human1.65167230
26CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61589473
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.61468467
28MAF_26560356_Chip-Seq_TH2_Human1.60556985
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58420397
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56830269
31LXR_22292898_ChIP-Seq_THP-1_Human1.56429750
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.55786438
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55632382
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55199552
35TCF7_22412390_ChIP-Seq_EML_Mouse1.54972823
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54323385
37UTX_26944678_Chip-Seq_JUKART_Human1.53711496
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.53292111
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52597925
40DCP1A_22483619_ChIP-Seq_HELA_Human1.51332141
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50526981
42KDM5A_27292631_Chip-Seq_BREAST_Human1.49639454
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48615405
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48580241
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.44951566
46* KDM2B_26808549_Chip-Seq_DND41_Human1.44786984
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44629334
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44029461
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40682468
50P68_20966046_ChIP-Seq_HELA_Human1.40658204
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.39939713
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39835314
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.37532718
54* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36632842
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35841822
56* NCOR1_26117541_ChIP-Seq_K562_Human1.35684618
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34512419
58* TTF2_22483619_ChIP-Seq_HELA_Human1.34234543
59GABP_17652178_ChIP-ChIP_JURKAT_Human1.33714696
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33638633
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32715893
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31759931
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.27438432
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27034640
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26407100
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25794691
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25611915
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25591766
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25501364
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25148612
71* SPI1_23547873_ChIP-Seq_NB4_Human1.24944007
72SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24868404
73BCL6_27268052_Chip-Seq_Bcells_Human1.24628164
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24529455
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24441870
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23759819
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23003920
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20867246
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20478773
80TFEB_21752829_ChIP-Seq_HELA_Human1.20231494
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19896360
82YY1_22570637_ChIP-Seq_MALME-3M_Human1.15661997
83FOXP3_21729870_ChIP-Seq_TREG_Human1.15255795
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14995417
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13432070
86VDR_24763502_ChIP-Seq_THP-1_Human1.12174978
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.11995670
88RACK7_27058665_Chip-Seq_MCF-7_Human1.08813994
89PHF8_20622854_ChIP-Seq_HELA_Human1.07187347
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07137687
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07099954
92BCOR_27268052_Chip-Seq_Bcells_Human1.06783055
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06173632
94CTCF_26484167_Chip-Seq_Bcells_Mouse1.05665707
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05377012
96BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03686594
97SCL_19346495_ChIP-Seq_HPC-7_Human1.03413586
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03229009
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01680624
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01488143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.47524141
2MP0008260_abnormal_autophagy3.41050022
3MP0003693_abnormal_embryo_hatching3.34321926
4MP0008058_abnormal_DNA_repair2.67528970
5MP0009333_abnormal_splenocyte_physiolog2.65026657
6MP0009278_abnormal_bone_marrow2.49995827
7MP0003111_abnormal_nucleus_morphology2.43950578
8MP0001873_stomach_inflammation2.35462475
9MP0003763_abnormal_thymus_physiology2.32086604
10MP0005058_abnormal_lysosome_morphology2.16889126
11MP0006292_abnormal_olfactory_placode2.11272631
12MP0003436_decreased_susceptibility_to2.04442979
13MP0010094_abnormal_chromosome_stability1.91158707
14MP0000678_abnormal_parathyroid_gland1.88104888
15MP0003077_abnormal_cell_cycle1.85059057
16MP0000465_gastrointestinal_hemorrhage1.76266840
17MP0002254_reproductive_system_inflammat1.67067555
18MP0002398_abnormal_bone_marrow1.66515924
19MP0003123_paternal_imprinting1.63947070
20MP0008877_abnormal_DNA_methylation1.62456025
21MP0005310_abnormal_salivary_gland1.58764592
22MP0000685_abnormal_immune_system1.57891595
23MP0004185_abnormal_adipocyte_glucose1.56690655
24MP0000703_abnormal_thymus_morphology1.56326602
25MP0005671_abnormal_response_to1.54087497
26MP0003303_peritoneal_inflammation1.53050685
27MP0001800_abnormal_humoral_immune1.52859508
28MP0001730_embryonic_growth_arrest1.52118191
29MP0008932_abnormal_embryonic_tissue1.51535824
30MP0004957_abnormal_blastocyst_morpholog1.50939776
31MP0001790_abnormal_immune_system1.50923340
32MP0005387_immune_system_phenotype1.50923340
33MP0008995_early_reproductive_senescence1.50421913
34MP0001853_heart_inflammation1.49015643
35MP0005501_abnormal_skin_physiology1.48282152
36MP0005075_abnormal_melanosome_morpholog1.47882560
37MP0005025_abnormal_response_to1.47035529
38MP0002722_abnormal_immune_system1.46744727
39MP0000490_abnormal_crypts_of1.45170212
40MP0001835_abnormal_antigen_presentation1.44918480
41MP0005000_abnormal_immune_tolerance1.44818255
42MP0002723_abnormal_immune_serum1.44425768
43MP0002132_abnormal_respiratory_system1.42706079
44MP0000689_abnormal_spleen_morphology1.41406675
45MP0001819_abnormal_immune_cell1.41132602
46MP0002420_abnormal_adaptive_immunity1.40037650
47MP0003172_abnormal_lysosome_physiology1.39059556
48MP0002452_abnormal_antigen_presenting1.37364893
49MP0002796_impaired_skin_barrier1.35513098
50MP0000716_abnormal_immune_system1.35058678
51MP0000313_abnormal_cell_death1.34259476
52MP0004147_increased_porphyrin_level1.31630996
53MP0002429_abnormal_blood_cell1.28619186
54MP0003806_abnormal_nucleotide_metabolis1.26751302
55MP0003656_abnormal_erythrocyte_physiolo1.22493292
56MP0004808_abnormal_hematopoietic_stem1.22327642
57MP0003221_abnormal_cardiomyocyte_apopto1.21395383
58MP0003786_premature_aging1.21352060
59MP0002405_respiratory_system_inflammati1.20933504
60MP0006035_abnormal_mitochondrial_morpho1.19128458
61MP0002419_abnormal_innate_immunity1.15883752
62MP0002210_abnormal_sex_determination1.15012418
63MP0004233_abnormal_muscle_weight1.12919166
64MP0000350_abnormal_cell_proliferation1.11110196
65MP0004947_skin_inflammation1.08479799
66MP0002019_abnormal_tumor_incidence1.06902673
67MP0009672_abnormal_birth_weight1.06900647
68MP0002138_abnormal_hepatobiliary_system1.04886524
69MP0010155_abnormal_intestine_physiology1.03583773
70MP0002653_abnormal_ependyma_morphology1.02619325
71MP0002148_abnormal_hypersensitivity_rea1.01381601
72MP0009785_altered_susceptibility_to1.00313474
73MP0001929_abnormal_gametogenesis0.99602531
74MP0005397_hematopoietic_system_phenotyp0.98676180
75MP0001545_abnormal_hematopoietic_system0.98676180
76MP0005464_abnormal_platelet_physiology0.98447344
77MP0003453_abnormal_keratinocyte_physiol0.98099516
78MP0010307_abnormal_tumor_latency0.97169246
79MP0005380_embryogenesis_phenotype0.97046026
80MP0001672_abnormal_embryogenesis/_devel0.97046026
81MP0000681_abnormal_thyroid_gland0.96254982
82MP0002080_prenatal_lethality0.93623121
83MP0002009_preneoplasia0.91083795
84MP0005076_abnormal_cell_differentiation0.90568573
85MP0003121_genomic_imprinting0.88500453
86MP0001145_abnormal_male_reproductive0.87903129
87MP0003984_embryonic_growth_retardation0.87688994
88MP0001764_abnormal_homeostasis0.86419566
89MP0009840_abnormal_foam_cell0.86243754
90MP0001845_abnormal_inflammatory_respons0.85720373
91MP0005360_urolithiasis0.85371947
92MP0004381_abnormal_hair_follicle0.85262572
93MP0002163_abnormal_gland_morphology0.84766097
94MP0001697_abnormal_embryo_size0.83059220
95MP0004197_abnormal_fetal_growth/weight/0.81708343
96MP0002088_abnormal_embryonic_growth/wei0.80717558
97MP0002928_abnormal_bile_duct0.77499946
98MP0009764_decreased_sensitivity_to0.74199587
99MP0004264_abnormal_extraembryonic_tissu0.73792807
100MP0001727_abnormal_embryo_implantation0.73657457

Predicted human phenotypes

RankGene SetZ-score
1Rhabdomyosarcoma (HP:0002859)4.22604013
2Long palpebral fissure (HP:0000637)3.47175867
3High anterior hairline (HP:0009890)3.00452169
4Diaphragmatic weakness (HP:0009113)2.94941482
5Increased IgM level (HP:0003496)2.94802193
6Abnormal gallbladder physiology (HP:0012438)2.82735942
7Cholecystitis (HP:0001082)2.82735942
8Neoplasm of striated muscle (HP:0009728)2.78479621
9Cortical dysplasia (HP:0002539)2.62757090
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.61527697
11Chronic obstructive pulmonary disease (HP:0006510)2.58563522
12Obstructive lung disease (HP:0006536)2.58563522
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.57115935
14Hypertensive crisis (HP:0100735)2.54503851
15Microvesicular hepatic steatosis (HP:0001414)2.54141899
16Insomnia (HP:0100785)2.53019929
17Progressive muscle weakness (HP:0003323)2.46576696
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.46411567
19Petechiae (HP:0000967)2.39817012
20Upper motor neuron abnormality (HP:0002127)2.39111451
21Thoracic kyphosis (HP:0002942)2.39032300
22Mediastinal lymphadenopathy (HP:0100721)2.36507741
23Abnormal tarsal ossification (HP:0008369)2.32533528
24Basal cell carcinoma (HP:0002671)2.29845857
25Fatigue (HP:0012378)2.28760241
26Fragile nails (HP:0001808)2.27202749
27Seborrheic dermatitis (HP:0001051)2.27063565
28Amaurosis fugax (HP:0100576)2.26108203
29Elevated alkaline phosphatase (HP:0003155)2.23873715
30Loss of speech (HP:0002371)2.23045831
31Squamous cell carcinoma (HP:0002860)2.21329225
32Recurrent cutaneous fungal infections (HP:0011370)2.20587457
33Chronic mucocutaneous candidiasis (HP:0002728)2.20587457
34Progressive external ophthalmoplegia (HP:0000590)2.20440634
35Premature loss of primary teeth (HP:0006323)2.19674852
36Reticulocytosis (HP:0001923)2.18251221
37Hyperacusis (HP:0010780)2.16534378
38Recurrent skin infections (HP:0001581)2.14627439
39Recurrent bacterial skin infections (HP:0005406)2.13968527
40Retinal dysplasia (HP:0007973)2.12143598
41Thrombocytosis (HP:0001894)2.11805062
42Hypercortisolism (HP:0001578)2.11608148
43Abnormality of reticulocytes (HP:0004312)2.10217919
44Colitis (HP:0002583)2.09815930
45Abnormality of alkaline phosphatase activity (HP:0004379)2.09434690
46Increased IgE level (HP:0003212)2.08768177
47Recurrent abscess formation (HP:0002722)2.08356661
48Microretrognathia (HP:0000308)2.07528519
49Myopathic facies (HP:0002058)2.07198637
50Abnormal enzyme/coenzyme activity (HP:0012379)2.04620826
51Short middle phalanx of the 5th finger (HP:0004220)2.02276437
52Panhypogammaglobulinemia (HP:0003139)2.01415293
53Shoulder girdle muscle weakness (HP:0003547)2.00844729
54Entropion (HP:0000621)2.00682874
55Gastrointestinal inflammation (HP:0004386)2.00516138
56Urticaria (HP:0001025)1.99253575
57Breast hypoplasia (HP:0003187)1.98257372
58Recurrent viral infections (HP:0004429)1.96958489
59Abnormal delayed hypersensitivity skin test (HP:0002963)1.96142109
60Segmental peripheral demyelination/remyelination (HP:0003481)1.95605334
61Ragged-red muscle fibers (HP:0003200)1.94332310
62Reticulocytopenia (HP:0001896)1.93258728
63J-shaped sella turcica (HP:0002680)1.92496877
64Meningitis (HP:0001287)1.91845749
65Cutaneous photosensitivity (HP:0000992)1.91687735
66Congenital ichthyosiform erythroderma (HP:0007431)1.90030237
67Deep palmar crease (HP:0006191)1.88431282
68Pustule (HP:0200039)1.85736542
69Abnormality of carpal bone ossification (HP:0006257)1.85451867
70Hypoplastic pelvis (HP:0008839)1.83428908
71Ependymoma (HP:0002888)1.81222638
72Agammaglobulinemia (HP:0004432)1.80889190
73Abnormality of the thoracic spine (HP:0100711)1.78575232
74Hand muscle atrophy (HP:0009130)1.77692247
75Optic nerve coloboma (HP:0000588)1.76386233
76Gastrointestinal infarctions (HP:0005244)1.75945830
77Premature ovarian failure (HP:0008209)1.75566371
78Abnormal foot bone ossification (HP:0010675)1.75257383
79Inflammation of the large intestine (HP:0002037)1.74406972
80Large eyes (HP:0001090)1.73487930
81Deep philtrum (HP:0002002)1.70190731
82Achilles tendon contracture (HP:0001771)1.70085955
83Reduced antithrombin III activity (HP:0001976)1.69962974
84Eczematoid dermatitis (HP:0000976)1.69400400
85Hyperthyroidism (HP:0000836)1.68097497
86Aplasia/Hypoplasia of the thymus (HP:0010515)1.68070688
87Deviation of the thumb (HP:0009603)1.67512029
88Severe global developmental delay (HP:0011344)1.67145560
89Poikiloderma (HP:0001029)1.65325026
90Flat occiput (HP:0005469)1.64892244
91Hepatosplenomegaly (HP:0001433)1.64814644
92Abnormal protein glycosylation (HP:0012346)1.64112092
93Abnormal glycosylation (HP:0012345)1.64112092
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64112092
95Abnormal protein N-linked glycosylation (HP:0012347)1.64112092
96Agnosia (HP:0010524)1.63909501
97Proximal placement of thumb (HP:0009623)1.63433302
98Trismus (HP:0000211)1.63386798
99Dysostosis multiplex (HP:0000943)1.62752737
100Cellulitis (HP:0100658)1.61301823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.47775261
2CDK194.17002983
3EEF2K2.49264341
4SMG12.41935522
5CDK122.31916212
6NME22.18511689
7PRPF4B2.15700368
8IRAK32.15461524
9TESK22.13953174
10NLK2.09077083
11DYRK32.08703431
12CDK41.94650824
13SIK21.93603645
14SIK11.86544563
15CDC71.85568917
16TRIB31.84148528
17MAP4K11.82124078
18TAOK11.70471483
19CDK31.66482275
20IKBKE1.62465527
21SIK31.57522062
22MAP3K111.51403209
23TBK11.41530685
24CSNK1G11.38876056
25BMX1.33857919
26MAPK71.30991145
27ERN11.30491278
28RIPK41.26975438
29ICK1.24880398
30RPS6KA41.21946367
31MAP2K31.21452017
32TYRO31.21424227
33MAP2K71.20538924
34BRAF1.18403595
35PASK1.13455024
36TTK1.12282682
37MAP3K31.11369366
38TAOK21.09430531
39FGR1.01311665
40SGK31.00885008
41IKBKB0.99527087
42NEK20.97693548
43EPHA20.96763366
44BCKDK0.95456999
45MAP3K140.94984511
46SGK20.94499602
47AURKA0.94049935
48CSF1R0.92231467
49IRAK40.88258268
50NME10.88166552
51PIM10.87851289
52BTK0.86482460
53LIMK10.84550160
54CDK70.84252141
55JAK30.83899477
56TNK20.83439032
57RPS6KB20.83108165
58PIM20.79148696
59VRK20.78813184
60DYRK1A0.78242845
61CDK60.75303481
62KSR20.68800265
63TYK20.68220048
64SGK4940.68054266
65SGK2230.68054266
66MATK0.65043841
67MAPK110.64903566
68MAPKAPK30.64683264
69ATR0.63806832
70TESK10.63715922
71PRKD20.62783122
72STK160.60102341
73MARK20.59860177
74MAP3K130.55257539
75CHUK0.54382273
76DYRK1B0.53690700
77HIPK20.52400765
78HCK0.52263987
79PAK10.51621815
80MAP3K80.51608376
81CDC42BPA0.51425160
82MTOR0.50598391
83CHEK10.49444206
84CDK90.47128633
85CHEK20.47058777
86FES0.47051640
87MAP3K40.47026158
88MAP3K10.46497227
89RPS6KC10.46278771
90RPS6KL10.46278771
91RPS6KA10.46172777
92IRAK20.46159654
93CSK0.44528671
94GRK60.43606572
95CDK20.41476072
96SRPK10.40981792
97MAPK90.38005298
98RPS6KA20.36843430
99MAPKAPK20.34172180
100CLK10.33488644

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034103.48244299
2DNA replication_Homo sapiens_hsa030303.09644320
3Mismatch repair_Homo sapiens_hsa034302.44649311
4Other glycan degradation_Homo sapiens_hsa005112.06216360
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99319379
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.99051152
7Acute myeloid leukemia_Homo sapiens_hsa052211.92128432
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90122823
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.87639341
10Spliceosome_Homo sapiens_hsa030401.80865270
11Herpes simplex infection_Homo sapiens_hsa051681.78740486
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74404613
13Sulfur relay system_Homo sapiens_hsa041221.71230361
14Biosynthesis of amino acids_Homo sapiens_hsa012301.66918618
15Primary immunodeficiency_Homo sapiens_hsa053401.64298520
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63190370
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.63033682
18B cell receptor signaling pathway_Homo sapiens_hsa046621.55999995
19Shigellosis_Homo sapiens_hsa051311.49209256
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47067062
21Hepatitis B_Homo sapiens_hsa051611.42396822
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39562153
23mRNA surveillance pathway_Homo sapiens_hsa030151.37700762
24Epstein-Barr virus infection_Homo sapiens_hsa051691.34329609
25Hepatitis C_Homo sapiens_hsa051601.32705157
26RNA transport_Homo sapiens_hsa030131.31540876
27Osteoclast differentiation_Homo sapiens_hsa043801.29007215
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.28212628
29Nucleotide excision repair_Homo sapiens_hsa034201.27561469
30Notch signaling pathway_Homo sapiens_hsa043301.27490152
31Homologous recombination_Homo sapiens_hsa034401.25826310
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23097984
33Fructose and mannose metabolism_Homo sapiens_hsa000511.18993098
34Measles_Homo sapiens_hsa051621.18350424
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16309802
36Apoptosis_Homo sapiens_hsa042101.15507148
37Chronic myeloid leukemia_Homo sapiens_hsa052201.14538387
38Influenza A_Homo sapiens_hsa051641.13275000
39Non-small cell lung cancer_Homo sapiens_hsa052231.10590061
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09555250
41Pentose phosphate pathway_Homo sapiens_hsa000301.09125314
42Pyrimidine metabolism_Homo sapiens_hsa002401.08006813
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04908395
44Cell cycle_Homo sapiens_hsa041101.04261850
45Pancreatic cancer_Homo sapiens_hsa052121.03779879
46Insulin resistance_Homo sapiens_hsa049311.03581983
47Ribosome_Homo sapiens_hsa030101.02284251
48Prostate cancer_Homo sapiens_hsa052151.01328356
49AMPK signaling pathway_Homo sapiens_hsa041521.00481534
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99415527
51Viral carcinogenesis_Homo sapiens_hsa052030.98219710
52mTOR signaling pathway_Homo sapiens_hsa041500.94898500
53Selenocompound metabolism_Homo sapiens_hsa004500.94512155
54Fanconi anemia pathway_Homo sapiens_hsa034600.89507625
55Antigen processing and presentation_Homo sapiens_hsa046120.88429525
56Insulin signaling pathway_Homo sapiens_hsa049100.86793471
57T cell receptor signaling pathway_Homo sapiens_hsa046600.86152915
58TNF signaling pathway_Homo sapiens_hsa046680.83612103
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83564049
60Legionellosis_Homo sapiens_hsa051340.82433453
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.79947917
62VEGF signaling pathway_Homo sapiens_hsa043700.79908692
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78432755
64Bladder cancer_Homo sapiens_hsa052190.78348898
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78125635
66RNA degradation_Homo sapiens_hsa030180.77905335
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77053275
68Tuberculosis_Homo sapiens_hsa051520.76782124
69Colorectal cancer_Homo sapiens_hsa052100.76391584
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76041577
71Regulation of autophagy_Homo sapiens_hsa041400.74378526
72Carbon metabolism_Homo sapiens_hsa012000.73337298
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.72330180
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.72241196
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70700130
76Galactose metabolism_Homo sapiens_hsa000520.69376872
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69045609
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68921783
79Leishmaniasis_Homo sapiens_hsa051400.68675119
80Lysosome_Homo sapiens_hsa041420.68379082
81Thyroid cancer_Homo sapiens_hsa052160.67090819
82Endometrial cancer_Homo sapiens_hsa052130.64893217
83Chemokine signaling pathway_Homo sapiens_hsa040620.64550419
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64035728
85Prolactin signaling pathway_Homo sapiens_hsa049170.62602930
86HTLV-I infection_Homo sapiens_hsa051660.61380640
87FoxO signaling pathway_Homo sapiens_hsa040680.58615831
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57382956
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55387158
90Proteasome_Homo sapiens_hsa030500.52767226
91Basal transcription factors_Homo sapiens_hsa030220.51210882
92RNA polymerase_Homo sapiens_hsa030200.50958471
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.50690021
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50660779
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.50259948
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.49815518
97ErbB signaling pathway_Homo sapiens_hsa040120.46604690
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44189125
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43551873
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.43442352

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