ZNF215

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.88959062
2regulation of meiosis I (GO:0060631)5.81797680
3regulation of DNA methylation (GO:0044030)5.80548849
4meiotic cell cycle (GO:0051321)5.04158045
5synapsis (GO:0007129)4.87329180
6DNA methylation involved in gamete generation (GO:0043046)4.84476813
7protein localization to kinetochore (GO:0034501)4.80522845
8regulation of female gonad development (GO:2000194)4.72415389
9CENP-A containing nucleosome assembly (GO:0034080)4.62240824
10retinal cone cell development (GO:0046549)4.54296981
11chromatin remodeling at centromere (GO:0031055)4.54138007
12DNA replication checkpoint (GO:0000076)4.49863594
13positive regulation of histone H3-K4 methylation (GO:0051571)4.46208170
14regulation of histone H3-K9 methylation (GO:0051570)4.39405637
15mitotic metaphase plate congression (GO:0007080)4.34982117
16centriole replication (GO:0007099)4.34321331
17regulation of mitotic spindle checkpoint (GO:1903504)4.16900672
18regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.16900672
19histone exchange (GO:0043486)4.09854870
20protein localization to chromosome, centromeric region (GO:0071459)4.05384591
21multicellular organism reproduction (GO:0032504)4.01361732
22DNA replication-dependent nucleosome organization (GO:0034723)3.95623547
23DNA replication-dependent nucleosome assembly (GO:0006335)3.95623547
24female gamete generation (GO:0007292)3.81674767
25gene silencing by RNA (GO:0031047)3.79725860
26positive regulation of mitotic sister chromatid separation (GO:1901970)3.79165359
27positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.79165359
28positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.79165359
29male meiosis I (GO:0007141)3.77428697
30regulation of acrosome reaction (GO:0060046)3.74486198
31metaphase plate congression (GO:0051310)3.71456735
32male meiosis (GO:0007140)3.68118271
33chromosome organization involved in meiosis (GO:0070192)3.67760893
34establishment of chromosome localization (GO:0051303)3.66031979
35negative regulation of DNA-dependent DNA replication (GO:2000104)3.64378894
36positive regulation of chromosome segregation (GO:0051984)3.64030499
37DNA replication-independent nucleosome assembly (GO:0006336)3.56193870
38DNA replication-independent nucleosome organization (GO:0034724)3.56193870
39attachment of spindle microtubules to kinetochore (GO:0008608)3.55895418
40proteasome assembly (GO:0043248)3.50216836
41DNA double-strand break processing (GO:0000729)3.35355426
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25642805
43RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.24669527
44negative regulation of histone methylation (GO:0031061)3.23770672
45meiotic cell cycle process (GO:1903046)3.20950769
46replication fork processing (GO:0031297)3.19628979
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18388639
48somatic hypermutation of immunoglobulin genes (GO:0016446)3.18388639
49meiosis I (GO:0007127)3.17535375
50DNA strand elongation involved in DNA replication (GO:0006271)3.16507198
51meiotic nuclear division (GO:0007126)3.13799183
52telomere maintenance via semi-conservative replication (GO:0032201)3.12626717
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12342074
54positive regulation of histone methylation (GO:0031062)3.11090751
55regulation of spindle checkpoint (GO:0090231)3.11033975
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09967798
57postreplication repair (GO:0006301)3.07647258
58DNA strand elongation (GO:0022616)3.06650702
59protein localization to chromosome (GO:0034502)3.03568699
60mitotic G2/M transition checkpoint (GO:0044818)3.02991253
61spindle checkpoint (GO:0031577)3.02811890
62translesion synthesis (GO:0019985)3.02686110
63protein K6-linked ubiquitination (GO:0085020)3.00695226
64regulation of double-strand break repair via homologous recombination (GO:0010569)3.00642196
65transcription elongation from RNA polymerase I promoter (GO:0006362)2.98965411
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98585643
67termination of RNA polymerase I transcription (GO:0006363)2.96595872
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95586246
69regulation of mitotic metaphase/anaphase transition (GO:0030071)2.95586246
70centriole assembly (GO:0098534)2.95317739
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94153487
72regulation of centriole replication (GO:0046599)2.92489120
73meiotic chromosome segregation (GO:0045132)2.91189244
74regulation of centrosome cycle (GO:0046605)2.89249419
75regulation of sister chromatid segregation (GO:0033045)2.88189635
76regulation of mitotic sister chromatid separation (GO:0010965)2.88189635
77regulation of mitotic sister chromatid segregation (GO:0033047)2.88189635
78positive regulation of gastrulation (GO:2000543)2.87401467
79nucleotide-excision repair, DNA gap filling (GO:0006297)2.85844530
80maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85418048
81histone mRNA metabolic process (GO:0008334)2.84122262
82mitotic chromosome condensation (GO:0007076)2.82258281
83glycine transport (GO:0015816)2.82044524
84nuclear pore organization (GO:0006999)2.81901642
85synaptonemal complex assembly (GO:0007130)2.81024394
86regulation of nuclear cell cycle DNA replication (GO:0033262)2.78598318
87nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.76760010
88somite rostral/caudal axis specification (GO:0032525)2.76683488
89synaptonemal complex organization (GO:0070193)2.76557712
90oocyte development (GO:0048599)2.76377732
91negative regulation of chromosome segregation (GO:0051985)2.75743406
92binding of sperm to zona pellucida (GO:0007339)2.75538407
93cullin deneddylation (GO:0010388)2.75254962
94negative regulation of mitotic sister chromatid separation (GO:2000816)2.74364997
95negative regulation of sister chromatid segregation (GO:0033046)2.74364997
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74364997
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74364997
98negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74364997
99DNA damage induced protein phosphorylation (GO:0006975)2.72781479
100telomere maintenance via recombination (GO:0000722)2.72280572

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.41304287
2EZH2_22144423_ChIP-Seq_EOC_Human5.06017285
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.79335888
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70014913
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.62598798
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36697551
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.00371806
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.93780019
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.81195427
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.76989070
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60441244
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.57633774
13ZNF274_21170338_ChIP-Seq_K562_Hela2.44903584
14VDR_22108803_ChIP-Seq_LS180_Human2.44446570
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.40449594
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.35094371
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.20082036
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19175376
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06895742
20EWS_26573619_Chip-Seq_HEK293_Human1.98400296
21ELK1_19687146_ChIP-ChIP_HELA_Human1.96406381
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95905574
23VDR_23849224_ChIP-Seq_CD4+_Human1.93630989
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90019722
25FOXP3_21729870_ChIP-Seq_TREG_Human1.82839337
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.82005796
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81237567
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78507764
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.78047934
30IRF1_19129219_ChIP-ChIP_H3396_Human1.64900637
31MYC_18940864_ChIP-ChIP_HL60_Human1.64649577
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63573282
33FUS_26573619_Chip-Seq_HEK293_Human1.62544038
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61718331
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60169057
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.59059561
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53462137
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50368046
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48712816
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48712816
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48712816
42P300_19829295_ChIP-Seq_ESCs_Human1.47749828
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46686209
44GBX2_23144817_ChIP-Seq_PC3_Human1.38690306
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37882169
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32764356
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32284449
48CBP_20019798_ChIP-Seq_JUKART_Human1.32284449
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31456570
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.29841126
51AR_21909140_ChIP-Seq_LNCAP_Human1.28479359
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.20767089
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20362130
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19920956
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19691053
56TP53_22573176_ChIP-Seq_HFKS_Human1.19153632
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.15980567
58TAF15_26573619_Chip-Seq_HEK293_Human1.14453724
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13952081
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13289941
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12279453
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11827130
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08788174
64DCP1A_22483619_ChIP-Seq_HELA_Human1.08467207
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07761614
66ER_23166858_ChIP-Seq_MCF-7_Human1.06625673
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05656305
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05497933
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.05497933
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03437884
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03096243
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02943200
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01494893
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.01427375
75TTF2_22483619_ChIP-Seq_HELA_Human1.01348735
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.00697759
77POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99661238
78THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99012372
79TCF4_23295773_ChIP-Seq_U87_Human0.98521460
80NANOG_19829295_ChIP-Seq_ESCs_Human0.97743657
81SOX2_19829295_ChIP-Seq_ESCs_Human0.97743657
82GABP_19822575_ChIP-Seq_HepG2_Human0.96914416
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93709629
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.92812420
85IGF1R_20145208_ChIP-Seq_DFB_Human0.92785495
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91998548
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91726650
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91500585
89HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90990805
90STAT3_23295773_ChIP-Seq_U87_Human0.90350393
91AR_20517297_ChIP-Seq_VCAP_Human0.89600519
92AR_25329375_ChIP-Seq_VCAP_Human0.89234748
93ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88509142
94E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87495286
95SMAD4_21741376_ChIP-Seq_EPCs_Human0.87279318
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87192543
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86210591
98HTT_18923047_ChIP-ChIP_STHdh_Human0.85322477
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85136116
100CDX2_22108803_ChIP-Seq_LS180_Human0.84985224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.22108772
2MP0008877_abnormal_DNA_methylation4.95487539
3MP0006292_abnormal_olfactory_placode4.19399113
4MP0003693_abnormal_embryo_hatching3.65740751
5MP0008058_abnormal_DNA_repair3.56999959
6MP0010094_abnormal_chromosome_stability3.55524526
7MP0008789_abnormal_olfactory_epithelium3.53119026
8MP0008057_abnormal_DNA_replication3.52689171
9MP0005499_abnormal_olfactory_system2.97539947
10MP0005394_taste/olfaction_phenotype2.97539947
11MP0003890_abnormal_embryonic-extraembry2.94388906
12MP0003111_abnormal_nucleus_morphology2.48720580
13MP0003077_abnormal_cell_cycle2.44415184
14MP0004957_abnormal_blastocyst_morpholog2.36607102
15MP0005395_other_phenotype2.22039743
16MP0001929_abnormal_gametogenesis2.16398773
17MP0002210_abnormal_sex_determination2.12391793
18MP0002234_abnormal_pharynx_morphology2.01360789
19MP0005410_abnormal_fertilization1.99556089
20MP0008932_abnormal_embryonic_tissue1.92735295
21MP0002160_abnormal_reproductive_system1.86808676
22MP0001293_anophthalmia1.83368842
23MP0000653_abnormal_sex_gland1.69979714
24MP0002102_abnormal_ear_morphology1.66322346
25MP0003699_abnormal_female_reproductive1.65636167
26MP0001145_abnormal_male_reproductive1.53593677
27MP0003786_premature_aging1.49071148
28MP0000427_abnormal_hair_cycle1.43587725
29MP0009697_abnormal_copulation1.43489889
30MP0003698_abnormal_male_reproductive1.43155446
31MP0005389_reproductive_system_phenotype1.43060597
32MP0002138_abnormal_hepatobiliary_system1.42146194
33MP0005551_abnormal_eye_electrophysiolog1.38662929
34MP0006072_abnormal_retinal_apoptosis1.38400294
35MP0010307_abnormal_tumor_latency1.37435462
36MP0002161_abnormal_fertility/fecundity1.35533267
37MP0001119_abnormal_female_reproductive1.31604509
38MP0001984_abnormal_olfaction1.30342759
39MP0003119_abnormal_digestive_system1.29932366
40MP0001730_embryonic_growth_arrest1.19952948
41MP0003941_abnormal_skin_development1.18348614
42MP0001986_abnormal_taste_sensitivity1.13141736
43MP0000631_abnormal_neuroendocrine_gland1.12829521
44MP0010030_abnormal_orbit_morphology1.07708189
45MP0003195_calcinosis1.06648005
46MP0003950_abnormal_plasma_membrane1.05055646
47MP0005646_abnormal_pituitary_gland1.04639212
48MP0002233_abnormal_nose_morphology1.04162215
49MP0006276_abnormal_autonomic_nervous1.02918198
50MP0000372_irregular_coat_pigmentation1.02301260
51MP0008007_abnormal_cellular_replicative1.01130633
52MP0000350_abnormal_cell_proliferation0.95537598
53MP0002139_abnormal_hepatobiliary_system0.95225180
54MP0004147_increased_porphyrin_level0.94508106
55MP0003121_genomic_imprinting0.94320486
56MP0005360_urolithiasis0.93551539
57MP0004043_abnormal_pH_regulation0.92736250
58MP0005380_embryogenesis_phenotype0.91941672
59MP0001672_abnormal_embryogenesis/_devel0.91941672
60MP0005645_abnormal_hypothalamus_physiol0.88663459
61MP0008995_early_reproductive_senescence0.85117065
62MP0002272_abnormal_nervous_system0.83428888
63MP0003252_abnormal_bile_duct0.83308128
64MP0005647_abnormal_sex_gland0.83220335
65MP0005253_abnormal_eye_physiology0.83017707
66MP0002638_abnormal_pupillary_reflex0.80499940
67MP0003937_abnormal_limbs/digits/tail_de0.79355980
68MP0002084_abnormal_developmental_patter0.78477988
69MP0001919_abnormal_reproductive_system0.77679262
70MP0000049_abnormal_middle_ear0.76495966
71MP0003567_abnormal_fetal_cardiomyocyte0.76308826
72MP0002751_abnormal_autonomic_nervous0.74881936
73MP0008775_abnormal_heart_ventricle0.70659712
74MP0008872_abnormal_physiological_respon0.70258805
75MP0004142_abnormal_muscle_tone0.70014217
76MP0006035_abnormal_mitochondrial_morpho0.68939571
77MP0000762_abnormal_tongue_morphology0.67937274
78MP0001697_abnormal_embryo_size0.67912036
79MP0003136_yellow_coat_color0.67445333
80MP0001286_abnormal_eye_development0.67333260
81MP0001968_abnormal_touch/_nociception0.66837426
82MP0002085_abnormal_embryonic_tissue0.66765734
83MP0001324_abnormal_eye_pigmentation0.64915308
84MP0003183_abnormal_peptide_metabolism0.64882934
85MP0001529_abnormal_vocalization0.64078056
86MP0006036_abnormal_mitochondrial_physio0.63789141
87MP0004215_abnormal_myocardial_fiber0.58229722
88MP0003646_muscle_fatigue0.58109192
89MP0000647_abnormal_sebaceous_gland0.57441932
90MP0001485_abnormal_pinna_reflex0.55878496
91MP0001764_abnormal_homeostasis0.55156770
92MP0005085_abnormal_gallbladder_physiolo0.55079720
93MP0000313_abnormal_cell_death0.54765508
94MP0002736_abnormal_nociception_after0.54720106
95MP0010678_abnormal_skin_adnexa0.54498815
96MP0002735_abnormal_chemical_nociception0.53425220
97MP0003186_abnormal_redox_activity0.53337587
98MP0005195_abnormal_posterior_eye0.53213502
99MP0001502_abnormal_circadian_rhythm0.52897974
100MP0002019_abnormal_tumor_incidence0.52073769

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22336293
2Chromsome breakage (HP:0040012)4.18755201
3Supernumerary spleens (HP:0009799)4.17719024
4Abnormality of the labia minora (HP:0012880)3.80050026
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.35317621
6Meckel diverticulum (HP:0002245)3.34754114
7Abnormality of chromosome stability (HP:0003220)3.20861125
8Abnormality of the ileum (HP:0001549)3.20501411
9Oligodactyly (hands) (HP:0001180)3.17430667
10Abnormality of abdominal situs (HP:0011620)3.08453113
11Abdominal situs inversus (HP:0003363)3.08453113
12Abnormality of midbrain morphology (HP:0002418)2.96114730
13Molar tooth sign on MRI (HP:0002419)2.96114730
14Abnormality of the preputium (HP:0100587)2.93353911
15Hypoplasia of the fovea (HP:0007750)2.85917040
16Aplasia/Hypoplasia of the fovea (HP:0008060)2.85917040
17Septo-optic dysplasia (HP:0100842)2.82275441
18Impulsivity (HP:0100710)2.76352233
19Colon cancer (HP:0003003)2.74686259
20Duodenal stenosis (HP:0100867)2.69026820
21Small intestinal stenosis (HP:0012848)2.69026820
22Short tibia (HP:0005736)2.67573227
23Pancreatic cysts (HP:0001737)2.66171831
24Azoospermia (HP:0000027)2.61757935
25Aplasia/Hypoplasia of the tibia (HP:0005772)2.61639989
26Pancreatic fibrosis (HP:0100732)2.58312877
27Abnormality of the fovea (HP:0000493)2.49751074
28Absent septum pellucidum (HP:0001331)2.44590541
29Methylmalonic acidemia (HP:0002912)2.40104666
30Median cleft lip (HP:0000161)2.36954077
31Abnormal lung lobation (HP:0002101)2.36751544
32Clubbing of toes (HP:0100760)2.34207048
33Abnormality of the duodenum (HP:0002246)2.33960769
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.33445069
35Pendular nystagmus (HP:0012043)2.33081137
36Horseshoe kidney (HP:0000085)2.30385715
37Facial hemangioma (HP:0000329)2.27156908
38Abnormality of the septum pellucidum (HP:0007375)2.26569369
39Abnormal spermatogenesis (HP:0008669)2.26346593
40Type II lissencephaly (HP:0007260)2.25262402
41Chronic hepatic failure (HP:0100626)2.22353082
42Birth length less than 3rd percentile (HP:0003561)2.21957324
43Abnormality of the pons (HP:0007361)2.20315022
44Anterior segment dysgenesis (HP:0007700)2.19773242
45Hypophosphatemic rickets (HP:0004912)2.17838108
46Absent thumb (HP:0009777)2.17291135
47Bile duct proliferation (HP:0001408)2.14178164
48Abnormal biliary tract physiology (HP:0012439)2.14178164
49Absent radius (HP:0003974)2.11824162
50Hypoplasia of the pons (HP:0012110)2.09062030
51Aplasia involving forearm bones (HP:0009822)2.05467404
52Absent forearm bone (HP:0003953)2.05467404
53Medial flaring of the eyebrow (HP:0010747)2.04042122
54Abnormality of the carotid arteries (HP:0005344)2.04040176
55Abnormality of the renal cortex (HP:0011035)2.03796525
56Sloping forehead (HP:0000340)2.02686847
57Nephroblastoma (Wilms tumor) (HP:0002667)2.01526175
58Duplicated collecting system (HP:0000081)2.01371355
59Gonadotropin excess (HP:0000837)2.01024881
60Renal cortical cysts (HP:0000803)1.98448116
61Nephronophthisis (HP:0000090)1.98329226
62Acute necrotizing encephalopathy (HP:0006965)1.98204348
63Ectopic kidney (HP:0000086)1.96984076
64Abnormality of the renal collecting system (HP:0004742)1.95320730
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94956527
66Increased hepatocellular lipid droplets (HP:0006565)1.94225844
67Embryonal renal neoplasm (HP:0011794)1.94104799
68Lipid accumulation in hepatocytes (HP:0006561)1.92437591
69Oligodactyly (HP:0012165)1.92108995
70Stillbirth (HP:0003826)1.91155989
71Methylmalonic aciduria (HP:0012120)1.90935475
72Triphalangeal thumb (HP:0001199)1.90608102
73Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90201173
74Acute encephalopathy (HP:0006846)1.87132921
75Megaloblastic anemia (HP:0001889)1.86948511
76Volvulus (HP:0002580)1.86828888
77Optic nerve hypoplasia (HP:0000609)1.86548955
78Premature ovarian failure (HP:0008209)1.84227350
79Short thumb (HP:0009778)1.83567185
80Dynein arm defect of respiratory motile cilia (HP:0012255)1.82689714
81Absent/shortened dynein arms (HP:0200106)1.82689714
82Attenuation of retinal blood vessels (HP:0007843)1.82216694
83Abnormality of DNA repair (HP:0003254)1.82069890
84Fair hair (HP:0002286)1.81912667
85Sensory axonal neuropathy (HP:0003390)1.78144643
86Progressive macrocephaly (HP:0004481)1.78110256
87Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.76267264
88Patellar aplasia (HP:0006443)1.76025082
89Abnormality of alanine metabolism (HP:0010916)1.75725033
90Hyperalaninemia (HP:0003348)1.75725033
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75725033
92Osteomalacia (HP:0002749)1.75612371
93Renal Fanconi syndrome (HP:0001994)1.75602356
94True hermaphroditism (HP:0010459)1.73681958
95Cleft eyelid (HP:0000625)1.72592049
96Anencephaly (HP:0002323)1.72365031
97Increased CSF lactate (HP:0002490)1.72362674
98Generalized aminoaciduria (HP:0002909)1.71242430
99Abnormality of the renal medulla (HP:0100957)1.71065477
100Posterior subcapsular cataract (HP:0007787)1.70386601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTK3.29894480
2ZAK3.17188793
3CDC72.96060148
4TRIM282.79648563
5EIF2AK32.78637409
6NUAK12.77333406
7BUB12.76323809
8MST42.58486405
9SRPK12.45151106
10MAP3K92.37898069
11PLK42.26812866
12BMPR1B2.20191068
13PLK32.17065695
14BRSK21.99621698
15TSSK61.91689835
16TAOK31.88812020
17MKNK21.83510642
18VRK11.81583689
19ARAF1.76523686
20PLK11.75875544
21INSRR1.74525150
22MAP3K131.70182089
23PBK1.63603335
24TLK11.59717001
25FRK1.59352980
26BRAF1.54130227
27TNIK1.51202091
28STK391.51109177
29EIF2AK11.49849413
30VRK21.47673483
31WNK31.44371897
32OXSR11.42275737
33NEK11.37779904
34AURKA1.35681208
35NEK21.32796901
36CDK91.30540571
37ACVR1B1.27732233
38WNK41.27453525
39MKNK11.26395852
40STK31.23619480
41CHEK21.21409522
42ADRBK21.21184966
43STK241.20615032
44NEK61.18372873
45TIE11.17509757
46PRKCI1.09624735
47STK161.09388385
48ATR1.06493187
49MET1.05423271
50BRSK11.03737031
51MAP4K21.01099524
52EIF2AK20.99585676
53CDK70.96862646
54GRK10.91067602
55AURKB0.88785829
56NME10.88468181
57WEE10.88022561
58CSNK1G10.86696582
59ATM0.85672205
60TGFBR10.85496512
61PLK20.84191327
62CHEK10.80664918
63RAF10.78429972
64CSNK1G30.74246048
65MAPK130.67589096
66TEC0.65250240
67MAP3K40.64160743
68MOS0.63224438
69CDK80.60337410
70MELK0.58795528
71CSNK1G20.58226243
72PIM10.58136562
73TAF10.57879038
74CSNK1A1L0.56448056
75CDK190.54405587
76CDK20.52710230
77PINK10.51977846
78CSNK1E0.50829784
79STK100.50266155
80CDK10.49997035
81MARK30.48069378
82FLT30.47606397
83MUSK0.46311706
84TXK0.42985489
85BCR0.42901122
86MAP3K80.42650296
87DYRK20.42642455
88CSNK1D0.41264678
89KSR10.40321311
90CSNK2A20.36397190
91STK40.35883996
92ERBB30.34090652
93CSNK2A10.33334956
94CASK0.33062036
95CAMK2A0.32053911
96MAPKAPK50.31965171
97PNCK0.30383890
98STK38L0.29497919
99PRKCE0.28589066
100PRKG10.28039730

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.76836750
2Mismatch repair_Homo sapiens_hsa034303.50374164
3Homologous recombination_Homo sapiens_hsa034403.21396069
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08487515
5DNA replication_Homo sapiens_hsa030302.95368602
6RNA polymerase_Homo sapiens_hsa030202.88798435
7Cell cycle_Homo sapiens_hsa041102.72520828
8RNA degradation_Homo sapiens_hsa030182.72207376
9Fanconi anemia pathway_Homo sapiens_hsa034602.66307462
10Proteasome_Homo sapiens_hsa030502.65469997
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.59033984
12RNA transport_Homo sapiens_hsa030132.31304657
13Base excision repair_Homo sapiens_hsa034102.30755803
14Non-homologous end-joining_Homo sapiens_hsa034502.30057143
15Nucleotide excision repair_Homo sapiens_hsa034202.25775620
16Caffeine metabolism_Homo sapiens_hsa002322.23929115
17Protein export_Homo sapiens_hsa030602.11288708
18Cysteine and methionine metabolism_Homo sapiens_hsa002702.10804514
19One carbon pool by folate_Homo sapiens_hsa006701.94756869
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81000376
21Oocyte meiosis_Homo sapiens_hsa041141.74597307
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70053878
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63946734
24Oxidative phosphorylation_Homo sapiens_hsa001901.63618283
25Phototransduction_Homo sapiens_hsa047441.57754906
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53907727
27Spliceosome_Homo sapiens_hsa030401.53129968
28Parkinsons disease_Homo sapiens_hsa050121.47241040
29Pyrimidine metabolism_Homo sapiens_hsa002401.43798000
30Propanoate metabolism_Homo sapiens_hsa006401.34793490
31Ribosome_Homo sapiens_hsa030101.33636942
32Selenocompound metabolism_Homo sapiens_hsa004501.32260081
33Huntingtons disease_Homo sapiens_hsa050161.30278973
34Purine metabolism_Homo sapiens_hsa002301.28977010
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25769445
36Olfactory transduction_Homo sapiens_hsa047401.23955168
37p53 signaling pathway_Homo sapiens_hsa041151.22644984
38Folate biosynthesis_Homo sapiens_hsa007901.16378489
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10539392
40Vitamin B6 metabolism_Homo sapiens_hsa007501.06792884
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06764544
42Steroid biosynthesis_Homo sapiens_hsa001000.99539900
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97725026
44Ovarian steroidogenesis_Homo sapiens_hsa049130.94064141
45mRNA surveillance pathway_Homo sapiens_hsa030150.90844075
46Linoleic acid metabolism_Homo sapiens_hsa005910.90055689
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82431093
48Pyruvate metabolism_Homo sapiens_hsa006200.82132513
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82038417
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80587340
51Butanoate metabolism_Homo sapiens_hsa006500.79200520
52Nitrogen metabolism_Homo sapiens_hsa009100.78847397
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76558370
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76044814
55Vitamin digestion and absorption_Homo sapiens_hsa049770.71422615
56Alzheimers disease_Homo sapiens_hsa050100.71110386
57Nicotine addiction_Homo sapiens_hsa050330.71080733
58Ether lipid metabolism_Homo sapiens_hsa005650.68110696
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67508619
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67272313
61Circadian rhythm_Homo sapiens_hsa047100.63512387
62Taste transduction_Homo sapiens_hsa047420.60434639
63Metabolic pathways_Homo sapiens_hsa011000.58620050
64Fatty acid elongation_Homo sapiens_hsa000620.58231562
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.52859661
66Cardiac muscle contraction_Homo sapiens_hsa042600.48855675
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47925531
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47624200
69Tryptophan metabolism_Homo sapiens_hsa003800.45074134
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44786263
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42213759
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39370933
73TGF-beta signaling pathway_Homo sapiens_hsa043500.36152593
74Arginine and proline metabolism_Homo sapiens_hsa003300.35907902
75Dorso-ventral axis formation_Homo sapiens_hsa043200.34997586
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34789102
77Retinol metabolism_Homo sapiens_hsa008300.34272386
78Peroxisome_Homo sapiens_hsa041460.31840040
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.28756590
80Regulation of autophagy_Homo sapiens_hsa041400.27438520
81Serotonergic synapse_Homo sapiens_hsa047260.26023585
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25216922
83Morphine addiction_Homo sapiens_hsa050320.24863275
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24301585
85ABC transporters_Homo sapiens_hsa020100.21525897
86Epstein-Barr virus infection_Homo sapiens_hsa051690.19285503
87Fat digestion and absorption_Homo sapiens_hsa049750.18666974
88Glutathione metabolism_Homo sapiens_hsa004800.18318446
89Chemical carcinogenesis_Homo sapiens_hsa052040.17334099
90Sulfur relay system_Homo sapiens_hsa041220.16655632
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15309495
92Hippo signaling pathway_Homo sapiens_hsa043900.15268593
93Sulfur metabolism_Homo sapiens_hsa009200.15061600
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.14014814
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.13269468
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.12800441
97Systemic lupus erythematosus_Homo sapiens_hsa053220.12649526
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10922668
99GABAergic synapse_Homo sapiens_hsa047270.09504544
100N-Glycan biosynthesis_Homo sapiens_hsa005100.09070535

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