ZNF217

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hepatocyte apoptotic process (GO:0097284)5.21502288
2regulation of histone H3-K27 methylation (GO:0061085)4.58866384
3positive regulation of keratinocyte differentiation (GO:0045618)4.49414998
4histone H3-K36 demethylation (GO:0070544)4.10320874
5nuclear pore complex assembly (GO:0051292)3.97469447
6regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.78590345
7positive regulation of Cdc42 GTPase activity (GO:0043089)3.74625526
8embryonic camera-type eye morphogenesis (GO:0048596)3.57393222
9intestinal epithelial cell development (GO:0060576)3.53282511
10ear development (GO:0043583)3.50147629
11trophectodermal cell differentiation (GO:0001829)3.48982381
12positive regulation by symbiont of host defense response (GO:0052509)3.41943195
13modulation by symbiont of host defense response (GO:0052031)3.41943195
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.41943195
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.41943195
16positive regulation by organism of defense response of other organism involved in symbiotic interact3.41943195
17modulation by symbiont of host immune response (GO:0052553)3.41943195
18embryonic process involved in female pregnancy (GO:0060136)3.36976344
19embryonic eye morphogenesis (GO:0048048)3.25342303
20epithelial cell differentiation involved in prostate gland development (GO:0060742)3.22668241
21regulation of RNA export from nucleus (GO:0046831)3.21970761
22phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.16365689
23interferon-gamma secretion (GO:0072643)3.11858157
24nuclear pore organization (GO:0006999)3.10234250
25regulation of establishment of cell polarity (GO:2000114)3.09733967
26pre-miRNA processing (GO:0031054)3.01300937
27insulin-like growth factor receptor signaling pathway (GO:0048009)2.98002638
28positive regulation of epidermal cell differentiation (GO:0045606)2.93452047
29negative regulation of DNA repair (GO:0045738)2.91708506
30histone lysine demethylation (GO:0070076)2.91314247
31positive regulation of gamma-delta T cell activation (GO:0046645)2.88726877
32positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.86111541
33maternal placenta development (GO:0001893)2.85405461
34regulation of nucleobase-containing compound transport (GO:0032239)2.82655548
35vagina development (GO:0060068)2.80569564
36regulation of centriole replication (GO:0046599)2.79279228
37histone demethylation (GO:0016577)2.74637808
38mitotic sister chromatid cohesion (GO:0007064)2.74113727
39leukocyte aggregation (GO:0070486)2.73874214
40regulation of establishment or maintenance of cell polarity (GO:0032878)2.69374258
41mammary gland epithelial cell proliferation (GO:0033598)2.67255304
42thymic T cell selection (GO:0045061)2.66740751
43pore complex assembly (GO:0046931)2.65862188
44branching involved in mammary gland duct morphogenesis (GO:0060444)2.65059741
45striated muscle atrophy (GO:0014891)2.63765867
46positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.62939051
47regulation of gamma-delta T cell activation (GO:0046643)2.60882464
48regulation of keratinocyte differentiation (GO:0045616)2.59659874
49cytoplasmic mRNA processing body assembly (GO:0033962)2.59185406
50regulation of interferon-beta biosynthetic process (GO:0045357)2.57514549
51regulation of cell proliferation involved in kidney development (GO:1901722)2.56724926
52cell-substrate adherens junction assembly (GO:0007045)2.55303021
53focal adhesion assembly (GO:0048041)2.55303021
54TOR signaling (GO:0031929)2.54690253
55cellular response to interferon-alpha (GO:0035457)2.54091394
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.51731493
57response to host (GO:0075136)2.51731493
58response to host defenses (GO:0052200)2.51731493
59regulation of gamma-delta T cell differentiation (GO:0045586)2.51490366
60mitotic chromosome condensation (GO:0007076)2.50465993
61RNA stabilization (GO:0043489)2.49726226
62mRNA stabilization (GO:0048255)2.49726226
63positive regulation of interferon-alpha production (GO:0032727)2.48388291
64regulation of interleukin-13 production (GO:0032656)2.47757367
65detection of molecule of bacterial origin (GO:0032490)2.47714397
66histone H3-K9 demethylation (GO:0033169)2.47481138
67regulation of B cell receptor signaling pathway (GO:0050855)2.45093565
68cell differentiation involved in embryonic placenta development (GO:0060706)2.45080348
69response to peptidoglycan (GO:0032494)2.44020705
70histone H3-K4 methylation (GO:0051568)2.43336698
71regulation of water loss via skin (GO:0033561)2.42820597
72T cell selection (GO:0045058)2.41861862
73regulation of chromatin binding (GO:0035561)2.41269273
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.40518555
75face development (GO:0060324)2.40375149
76intracellular estrogen receptor signaling pathway (GO:0030520)2.38815557
77cellular response to epidermal growth factor stimulus (GO:0071364)2.37757532
78histone H3-K4 trimethylation (GO:0080182)2.37549730
79negative regulation of viral release from host cell (GO:1902187)2.37483602
80cellular response to virus (GO:0098586)2.35338433
81protein demethylation (GO:0006482)2.34785425
82protein dealkylation (GO:0008214)2.34785425
83adherens junction assembly (GO:0034333)2.33741854
84iron ion import (GO:0097286)2.32748667
85positive regulation of insulin receptor signaling pathway (GO:0046628)2.30932761
86macrophage activation involved in immune response (GO:0002281)2.30444361
87determination of adult lifespan (GO:0008340)2.29690559
88positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.29350291
89activation of Rac GTPase activity (GO:0032863)2.28036071
903-UTR-mediated mRNA stabilization (GO:0070935)2.26310066
91chondrocyte development (GO:0002063)2.26257107
92ER overload response (GO:0006983)2.26168947
93corticosteroid receptor signaling pathway (GO:0031958)2.24505597
94response to epidermal growth factor (GO:0070849)2.24196590
95G1 DNA damage checkpoint (GO:0044783)2.24169661
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.24150123
97protein export from nucleus (GO:0006611)2.23761902
98skeletal muscle adaptation (GO:0043501)2.23700047
99positive regulation of macroautophagy (GO:0016239)2.22600743
100response to host immune response (GO:0052572)2.22132538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.97083760
2ESR1_20079471_ChIP-ChIP_T-47D_Human3.48540691
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.41335540
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.19163532
5E2F7_22180533_ChIP-Seq_HELA_Human3.07051813
6MYC_22102868_ChIP-Seq_BL_Human3.05726306
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.02250524
8* ESR2_21235772_ChIP-Seq_MCF-7_Human2.99336957
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.56667337
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.47249010
11TCF7_22412390_ChIP-Seq_EML_Mouse2.44487478
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.16907291
13* RUNX1_27514584_Chip-Seq_MCF-7_Human2.09874065
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.05585385
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02551145
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.98762752
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95907281
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.94694121
19PKCTHETA_26484144_Chip-Seq_BREAST_Human1.91658215
20RACK7_27058665_Chip-Seq_MCF-7_Human1.89238181
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88622798
22* VDR_21846776_ChIP-Seq_THP-1_Human1.88283497
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84191665
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83880798
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81836118
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81045515
27* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71776297
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.66836679
29AHR_22903824_ChIP-Seq_MCF-7_Human1.64968689
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.64751301
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.62942718
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.62942718
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.62942718
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62498010
35CHD1_26751641_Chip-Seq_LNCaP_Human1.59543473
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.57822881
37* VDR_24763502_ChIP-Seq_THP-1_Human1.57217482
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56561290
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56431661
40* MYB_26560356_Chip-Seq_TH1_Human1.56431643
41MAF_26560356_Chip-Seq_TH1_Human1.55893986
42AR_21909140_ChIP-Seq_LNCAP_Human1.48040074
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47999278
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46368229
45KDM2B_26808549_Chip-Seq_DND41_Human1.45972874
46CLOCK_20551151_ChIP-Seq_293T_Human1.45122235
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44851020
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42863494
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42291065
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42291065
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.40710378
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39351886
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.38540282
54GATA6_25053715_ChIP-Seq_YYC3_Human1.38452114
55MYB_26560356_Chip-Seq_TH2_Human1.38188577
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36222021
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35393494
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34168001
59SCL_19346495_ChIP-Seq_HPC-7_Human1.31984949
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31843089
61UTX_26944678_Chip-Seq_JUKART_Human1.31026950
62GATA1_22025678_ChIP-Seq_K562_Human1.30614396
63RUNX_20019798_ChIP-Seq_JUKART_Human1.30511039
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.29102654
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.28960228
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28571894
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27323247
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27279683
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26937321
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.24939264
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24323623
72ZNF263_19887448_ChIP-Seq_K562_Human1.24170982
73ATF3_27146783_Chip-Seq_COLON_Human1.22531407
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22177176
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.22071800
76* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19487449
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19051681
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19017005
79SPI1_23547873_ChIP-Seq_NB4_Human1.18626652
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18488930
81* ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18383741
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15943995
83IRF8_27001747_Chip-Seq_BMDM_Mouse1.14991798
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14554967
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.13318311
86PU_27001747_Chip-Seq_BMDM_Mouse1.13070773
87* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12479048
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09885592
89TFEB_21752829_ChIP-Seq_HELA_Human1.07342216
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07072830
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.06981113
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05802527
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05399000
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.05331011
95* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04305236
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04173292
97NCOR1_26117541_ChIP-Seq_K562_Human1.03268046
98KDM5A_27292631_Chip-Seq_BREAST_Human1.01053585
99KDM2B_26808549_Chip-Seq_K562_Human0.98984142
100MAF_26560356_Chip-Seq_TH2_Human0.98251942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu3.33335528
2MP0005076_abnormal_cell_differentiation3.19596549
3MP0008057_abnormal_DNA_replication2.96048707
4MP0003705_abnormal_hypodermis_morpholog2.75009707
5MP0002009_preneoplasia2.65751841
6MP0002166_altered_tumor_susceptibility2.61838673
7MP0002796_impaired_skin_barrier2.60853773
8MP0004381_abnormal_hair_follicle2.52749638
9MP0005451_abnormal_body_composition2.42383490
10MP0002396_abnormal_hematopoietic_system2.25570432
11MP0001873_stomach_inflammation2.07635854
12MP0010234_abnormal_vibrissa_follicle2.06589639
13MP0003763_abnormal_thymus_physiology1.91693792
14MP0004233_abnormal_muscle_weight1.89894641
15MP0008260_abnormal_autophagy1.86377809
16MP0004185_abnormal_adipocyte_glucose1.85272106
17MP0003191_abnormal_cellular_cholesterol1.85157545
18MP0002877_abnormal_melanocyte_morpholog1.81753529
19MP0003566_abnormal_cell_adhesion1.80536721
20MP0002006_tumorigenesis1.78395633
21MP0004947_skin_inflammation1.77060932
22MP0010352_gastrointestinal_tract_polyps1.75823573
23MP0010307_abnormal_tumor_latency1.56241971
24MP0000627_abnormal_mammary_gland1.54214088
25MP0004808_abnormal_hematopoietic_stem1.50532658
26MP0005501_abnormal_skin_physiology1.46739700
27MP0003183_abnormal_peptide_metabolism1.44602983
28MP0000858_altered_metastatic_potential1.43361107
29MP0002098_abnormal_vibrissa_morphology1.42933724
30MP0005408_hypopigmentation1.37950038
31MP0003453_abnormal_keratinocyte_physiol1.37372549
32MP0001800_abnormal_humoral_immune1.36020016
33MP0000703_abnormal_thymus_morphology1.35011095
34MP0001835_abnormal_antigen_presentation1.32133520
35MP0009672_abnormal_birth_weight1.32096792
36MP0003091_abnormal_cell_migration1.30196464
37MP0003300_gastrointestinal_ulcer1.27728353
38MP0002398_abnormal_bone_marrow1.27519050
39MP0010678_abnormal_skin_adnexa1.26088029
40MP0003436_decreased_susceptibility_to1.24442051
41MP0003693_abnormal_embryo_hatching1.21362847
42MP0000685_abnormal_immune_system1.20029085
43MP0005409_darkened_coat_color1.19808480
44MP0000350_abnormal_cell_proliferation1.19746077
45MP0000383_abnormal_hair_follicle1.19723003
46MP0004957_abnormal_blastocyst_morpholog1.18685564
47MP0000377_abnormal_hair_follicle1.18093786
48MP0002086_abnormal_extraembryonic_tissu1.16848607
49MP0005075_abnormal_melanosome_morpholog1.16051155
50MP0003077_abnormal_cell_cycle1.15313733
51MP0005310_abnormal_salivary_gland1.14607382
52MP0002088_abnormal_embryonic_growth/wei1.14406029
53MP0003984_embryonic_growth_retardation1.13153584
54MP0001216_abnormal_epidermal_layer1.11903370
55MP0003221_abnormal_cardiomyocyte_apopto1.11608928
56MP0003866_abnormal_defecation1.11476686
57MP0009278_abnormal_bone_marrow1.11121725
58MP0001672_abnormal_embryogenesis/_devel1.10222709
59MP0005380_embryogenesis_phenotype1.10222709
60MP0002452_abnormal_antigen_presenting1.08539517
61MP0003303_peritoneal_inflammation1.08317748
62MP0001730_embryonic_growth_arrest1.06939439
63MP0002722_abnormal_immune_system1.05264485
64MP0003111_abnormal_nucleus_morphology1.04554021
65MP0005621_abnormal_cell_physiology1.04353514
66MP0005000_abnormal_immune_tolerance1.03564925
67MP0001819_abnormal_immune_cell1.03282135
68MP0002420_abnormal_adaptive_immunity1.03227391
69MP0003828_pulmonary_edema1.02621678
70MP0003941_abnormal_skin_development1.00843048
71MP0005248_abnormal_Harderian_gland1.00086217
72MP0000716_abnormal_immune_system0.98236626
73MP0002723_abnormal_immune_serum0.97294767
74MP0000537_abnormal_urethra_morphology0.96904514
75MP0000689_abnormal_spleen_morphology0.95858504
76MP0010155_abnormal_intestine_physiology0.95727405
77MP0002419_abnormal_innate_immunity0.94097089
78MP0001849_ear_inflammation0.93258844
79MP0001348_abnormal_lacrimal_gland0.92762944
80MP0010094_abnormal_chromosome_stability0.92529359
81MP0005025_abnormal_response_to0.92502113
82MP0001697_abnormal_embryo_size0.90337691
83MP0002019_abnormal_tumor_incidence0.89940078
84MP0009703_decreased_birth_body0.89280692
85MP0002429_abnormal_blood_cell0.89135418
86MP0005666_abnormal_adipose_tissue0.88293800
87MP0001727_abnormal_embryo_implantation0.87678958
88MP0000371_diluted_coat_color0.87491207
89MP0002060_abnormal_skin_morphology0.86568642
90MP0002080_prenatal_lethality0.86529105
91MP0005387_immune_system_phenotype0.86438978
92MP0001790_abnormal_immune_system0.86438978
93MP0001881_abnormal_mammary_gland0.86035195
94MP0004782_abnormal_surfactant_physiolog0.84526178
95MP0003123_paternal_imprinting0.83943955
96MP0002405_respiratory_system_inflammati0.83489781
97MP0009115_abnormal_fat_cell0.83473643
98MP0004197_abnormal_fetal_growth/weight/0.81583328
99MP0005671_abnormal_response_to0.81250761
100MP0004883_abnormal_blood_vessel0.80660055

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)4.06796333
2Absent frontal sinuses (HP:0002688)3.66276698
3Micronodular cirrhosis (HP:0001413)3.58018402
4Sparse lateral eyebrow (HP:0005338)3.35367890
5Curly hair (HP:0002212)3.19402085
6J-shaped sella turcica (HP:0002680)3.05764658
7Syringomyelia (HP:0003396)2.99300131
8Spinal cord lesions (HP:0100561)2.99300131
9Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.95233480
10Septate vagina (HP:0001153)2.84953723
11Abnormality of the fingertips (HP:0001211)2.80621487
12Germ cell neoplasia (HP:0100728)2.78695002
13Flat acetabular roof (HP:0003180)2.77632141
14Subacute progressive viral hepatitis (HP:0006572)2.75443044
15Lip pit (HP:0100267)2.73714800
16Deep philtrum (HP:0002002)2.70340227
17Papillary thyroid carcinoma (HP:0002895)2.67787164
18Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.60494177
19Broad face (HP:0000283)2.57602557
20Breast carcinoma (HP:0003002)2.57093021
21Abnormality of the frontal sinuses (HP:0002687)2.55330012
22Eczematoid dermatitis (HP:0000976)2.54113153
23Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.53576297
24Esophageal varix (HP:0002040)2.47368265
25Microglossia (HP:0000171)2.46324595
26Slow saccadic eye movements (HP:0000514)2.40412371
27Leiomyosarcoma (HP:0100243)2.39981514
28Uterine leiomyosarcoma (HP:0002891)2.39981514
29Nephroblastoma (Wilms tumor) (HP:0002667)2.36819787
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.36305684
31Macroorchidism (HP:0000053)2.35335589
32Deformed sella turcica (HP:0002681)2.34105997
33Chromsome breakage (HP:0040012)2.31948490
34Transitional cell carcinoma of the bladder (HP:0006740)2.31724143
35Recurrent abscess formation (HP:0002722)2.26793730
36Abnormality of the distal phalanx of the thumb (HP:0009617)2.25381829
37Hyperacusis (HP:0010780)2.24695965
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24643726
39Malignant gastrointestinal tract tumors (HP:0006749)2.24619123
40Gastrointestinal carcinoma (HP:0002672)2.24619123
41Back pain (HP:0003418)2.22415020
42Bladder carcinoma (HP:0002862)2.19107741
43Bladder neoplasm (HP:0009725)2.19107741
44Embryonal renal neoplasm (HP:0011794)2.16011123
45Viral hepatitis (HP:0006562)2.15473775
46Recurrent bacterial skin infections (HP:0005406)2.14251976
47Renal cell carcinoma (HP:0005584)2.03736236
48T lymphocytopenia (HP:0005403)2.03191287
49Testicular neoplasm (HP:0010788)2.01640254
50Neonatal hypoglycemia (HP:0001998)1.97031853
51Advanced eruption of teeth (HP:0006288)1.89204221
52Anal stenosis (HP:0002025)1.88772771
53Colitis (HP:0002583)1.88562241
54Dysmetric saccades (HP:0000641)1.88562024
55Abdominal distention (HP:0003270)1.86693129
56Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85167227
57Abnormal foot bone ossification (HP:0010675)1.81961165
58Arterial tortuosity (HP:0005116)1.80107459
59Osteolytic defects of the hand bones (HP:0009699)1.79239580
60Osteolytic defects of the phalanges of the hand (HP:0009771)1.79239580
61Thyroid carcinoma (HP:0002890)1.78847871
62Right ventricular cardiomyopathy (HP:0011663)1.78016818
63Heterotopia (HP:0002282)1.77487175
64Long eyelashes (HP:0000527)1.77157711
65Recurrent viral infections (HP:0004429)1.76973347
66Long palpebral fissure (HP:0000637)1.76667556
67Thin bony cortex (HP:0002753)1.76463029
68Termporal pattern (HP:0011008)1.76319885
69Insidious onset (HP:0003587)1.76319885
70Abnormality of the nasal septum (HP:0000419)1.76055658
71Acute myeloid leukemia (HP:0004808)1.75869343
72Abnormality of T cell number (HP:0011839)1.72837215
73Abnormality of the radial head (HP:0003995)1.72805337
74Cellulitis (HP:0100658)1.71841675
75Deep venous thrombosis (HP:0002625)1.71335338
76Arterial thrombosis (HP:0004420)1.71092444
77Dislocated radial head (HP:0003083)1.70893384
78Recurrent fungal infections (HP:0002841)1.67010864
79Coarse hair (HP:0002208)1.65051215
80Abnormal vertebral ossification (HP:0100569)1.64585770
81Abnormality of the gastric mucosa (HP:0004295)1.61716524
82Prominent nose (HP:0000448)1.59202695
83Menstrual irregularities (HP:0000858)1.58786223
84Prostate neoplasm (HP:0100787)1.58643439
85Persistence of primary teeth (HP:0006335)1.57934737
86Gingivitis (HP:0000230)1.57673233
87Abnormality of the sella turcica (HP:0002679)1.56512171
88Acute lymphatic leukemia (HP:0006721)1.56435914
89Aplasia cutis congenita (HP:0001057)1.56238804
90Abnormality of the phalanges of the hallux (HP:0010057)1.54217333
91Abnormality of the thoracic spine (HP:0100711)1.53101662
92Deviation of the thumb (HP:0009603)1.52246124
93Metaphyseal cupping (HP:0003021)1.52117840
94Uterine neoplasm (HP:0010784)1.51851257
95Missing ribs (HP:0000921)1.51822892
96Chronic mucocutaneous candidiasis (HP:0002728)1.51258877
97Recurrent cutaneous fungal infections (HP:0011370)1.51258877
98Abnormality of macrophages (HP:0004311)1.50893947
99Meningitis (HP:0001287)1.50465418
100Hypopigmentation of the fundus (HP:0007894)1.50195949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.59312404
2SMG13.12898794
3CDK123.08853659
4PKN22.92194049
5EPHA22.78248480
6SIK12.74016708
7SCYL22.60302688
8RPS6KB22.43084570
9FGFR42.21863195
10RIPK42.15733162
11MAP3K102.06573477
12EEF2K1.92920779
13PRPF4B1.81687607
14PIK3CA1.81521464
15SIK31.79691948
16CAMK1D1.60558694
17NEK61.58601146
18BRD41.46657708
19BRSK21.41258776
20TAF11.34318660
21MAP3K141.33166975
22YES11.33001464
23CHUK1.32542525
24IRAK41.31433802
25CAMK1G1.28712060
26ICK1.27494087
27AKT31.25972659
28IKBKE1.25606945
29ERN11.24553671
30FGFR31.17887918
31MTOR1.16238326
32CSF1R1.14611161
33IRAK31.13301816
34PTK61.12282676
35MELK1.12222625
36KSR21.10229300
37MAP3K21.04311464
38MAP3K31.01592542
39MAP4K11.00926313
40CDK60.99631129
41MAP2K20.97297444
42SGK30.97194058
43GRK60.97032196
44CDK70.93326415
45TAOK10.90076834
46MAP2K30.87289191
47RET0.85960124
48TYK20.84154535
49LRRK20.83753594
50PAK40.83152739
51CSK0.83014202
52MAP3K130.77993948
53KSR10.77686388
54JAK10.77481724
55SGK20.76049131
56BTK0.74030521
57PDGFRA0.73798250
58IKBKB0.73220603
59BLK0.70269520
60RPS6KA20.69790551
61STK240.68779676
62EIF2AK10.68755877
63CDK40.64954048
64RPS6KB10.63883544
65FGR0.63715147
66WNK10.63354056
67RPS6KC10.61886894
68RPS6KL10.61886894
69TTN0.61034995
70PDPK10.60890330
71BMPR20.60311099
72MAP3K10.59951453
73MAP3K120.59918121
74HIPK20.58074848
75JAK30.57745135
76LATS10.56673240
77STK40.54509238
78PDK10.54221533
79RIPK10.53940286
80MAPKAPK30.53464627
81TBK10.51963153
82IRAK20.51643766
83EPHB10.51445173
84STK38L0.51222531
85HCK0.50889842
86PDGFRB0.50324988
87STK380.50155476
88DYRK30.49995283
89MAPKAPK20.49419289
90PRKCI0.48353094
91PRKD20.45788325
92JAK20.45098866
93MAP2K10.44684975
94WEE10.44530076
95FGFR10.43764651
96MST40.43546579
97RPS6KA60.42180649
98TNK20.40098528
99RAF10.39163944
100PTK20.38625178

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052162.52747105
2Acute myeloid leukemia_Homo sapiens_hsa052212.47565980
3Non-small cell lung cancer_Homo sapiens_hsa052232.43994709
4Endometrial cancer_Homo sapiens_hsa052132.33774465
5B cell receptor signaling pathway_Homo sapiens_hsa046622.31857396
6Chronic myeloid leukemia_Homo sapiens_hsa052202.22990424
7Prostate cancer_Homo sapiens_hsa052151.88292784
8Renal cell carcinoma_Homo sapiens_hsa052111.87717525
9Pancreatic cancer_Homo sapiens_hsa052121.78793625
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67246398
11T cell receptor signaling pathway_Homo sapiens_hsa046601.58730183
12Hepatitis C_Homo sapiens_hsa051601.57538839
13Hepatitis B_Homo sapiens_hsa051611.54579682
14Measles_Homo sapiens_hsa051621.53463499
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53328481
16Thyroid hormone signaling pathway_Homo sapiens_hsa049191.53082476
17mTOR signaling pathway_Homo sapiens_hsa041501.52704549
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50758776
19ErbB signaling pathway_Homo sapiens_hsa040121.46650432
20Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.43051146
21Bladder cancer_Homo sapiens_hsa052191.41536190
22Prolactin signaling pathway_Homo sapiens_hsa049171.40879980
23VEGF signaling pathway_Homo sapiens_hsa043701.39906599
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.39830994
25Colorectal cancer_Homo sapiens_hsa052101.37341313
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.36768660
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.35854426
28Influenza A_Homo sapiens_hsa051641.35510180
29Osteoclast differentiation_Homo sapiens_hsa043801.33859208
30MicroRNAs in cancer_Homo sapiens_hsa052061.30102473
31Leishmaniasis_Homo sapiens_hsa051401.27062519
32Small cell lung cancer_Homo sapiens_hsa052221.26977648
33Glioma_Homo sapiens_hsa052141.26632747
34Choline metabolism in cancer_Homo sapiens_hsa052311.21886254
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21136567
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.21076278
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19598197
38Inositol phosphate metabolism_Homo sapiens_hsa005621.19040351
39Proteoglycans in cancer_Homo sapiens_hsa052051.18292899
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17389960
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.16767378
42FoxO signaling pathway_Homo sapiens_hsa040681.16756392
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16576102
44Adherens junction_Homo sapiens_hsa045201.15985337
45Viral carcinogenesis_Homo sapiens_hsa052031.15096513
46Apoptosis_Homo sapiens_hsa042101.12728482
47Notch signaling pathway_Homo sapiens_hsa043301.10581685
48Herpes simplex infection_Homo sapiens_hsa051681.08899696
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07111736
50Insulin resistance_Homo sapiens_hsa049311.06995594
51HIF-1 signaling pathway_Homo sapiens_hsa040661.04813503
52Insulin signaling pathway_Homo sapiens_hsa049101.03707042
53Estrogen signaling pathway_Homo sapiens_hsa049151.01591014
54Toxoplasmosis_Homo sapiens_hsa051451.00909369
55mRNA surveillance pathway_Homo sapiens_hsa030150.97482123
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.95730212
57AMPK signaling pathway_Homo sapiens_hsa041520.94786745
58TNF signaling pathway_Homo sapiens_hsa046680.93545308
59Chemokine signaling pathway_Homo sapiens_hsa040620.92935386
60Tuberculosis_Homo sapiens_hsa051520.92358595
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.89159902
62Epstein-Barr virus infection_Homo sapiens_hsa051690.86487947
63HTLV-I infection_Homo sapiens_hsa051660.85473111
64Legionellosis_Homo sapiens_hsa051340.83964638
65Platelet activation_Homo sapiens_hsa046110.80287114
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79402210
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79384486
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78565659
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78140733
70Lysine degradation_Homo sapiens_hsa003100.77020486
71Melanoma_Homo sapiens_hsa052180.74596704
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71533859
73Cell cycle_Homo sapiens_hsa041100.71133920
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70006339
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69838486
76Dorso-ventral axis formation_Homo sapiens_hsa043200.67458497
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.65913736
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65725736
79Endocytosis_Homo sapiens_hsa041440.64640756
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64462805
81Amoebiasis_Homo sapiens_hsa051460.62430113
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.59798701
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58748989
84Focal adhesion_Homo sapiens_hsa045100.58491256
85Primary immunodeficiency_Homo sapiens_hsa053400.58448896
86Pathways in cancer_Homo sapiens_hsa052000.58331444
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58270321
88p53 signaling pathway_Homo sapiens_hsa041150.56764834
89Shigellosis_Homo sapiens_hsa051310.56024676
90Viral myocarditis_Homo sapiens_hsa054160.55704608
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53667786
92TGF-beta signaling pathway_Homo sapiens_hsa043500.52307469
93Tight junction_Homo sapiens_hsa045300.51880599
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49950431
95Fatty acid biosynthesis_Homo sapiens_hsa000610.49562807
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48969523
97GnRH signaling pathway_Homo sapiens_hsa049120.48955556
98Type II diabetes mellitus_Homo sapiens_hsa049300.48312116
99Hematopoietic cell lineage_Homo sapiens_hsa046400.47896367
100RNA transport_Homo sapiens_hsa030130.47326508

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